- Regulation of cell survival by secreted proneurotrophins
Division of Hematology, Department of Medicine, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
Science 294:1945-8. 2001
..The biological action of neurotrophins is thus regulated by proteolytic cleavage, with proforms preferentially activating p75NTR to mediate apoptosis and mature forms activating Trk receptors to promote survival...
- Effect of procalcitonin-based guidelines vs standard guidelines on antibiotic use in lower respiratory tract infections: the ProHOSP randomized controlled trial
Department of Internal Medicine, Kantonsspital Aarau, Tellstrasse, CH 5001 Aarau, Switzerland
JAMA 302:1059-66. 2009
..In previous smaller trials, a procalcitonin (PCT) algorithm reduced antibiotic use in patients with lower respiratory tract infections (LRTIs)...
- Cleavage of proBDNF by tPA/plasmin is essential for long-term hippocampal plasticity
Petti T Pang
Section on Neural Development and Plasticity, Laboratory of Cellular and Synaptic Neurophysiology, National Institute of Child Health and Human Development NICHD, Bethesda, MD 20892, USA
Science 306:487-91. 2004
..Moreover, application of mBDNF is sufficient to rescue L-LTP when protein synthesis is inhibited, which suggests that mBDNF is a key protein synthesis product for L-LTP expression...
- Assay for the measurement of copeptin, a stable peptide derived from the precursor of vasopressin
Nils G Morgenthaler
Research Department, B R A H M S AG, Biotechnology Centre Hennigsdorf Berlin, Germany
Clin Chem 52:112-9. 2006
..We present a method for quantifying AVP release by use of copeptin, a glycopeptide comprising the C-terminal part of the AVP prohormone...
- Procalcitonin as a diagnostic test for sepsis in critically ill adults and after surgery or trauma: a systematic review and meta-analysis
APHP Laboratoire de Pharmacologie Hormonologie, Hopital Avicenne, Bobigny, France
Crit Care Med 34:1996-2003. 2006
..To draw and compare the summary receiver operating characteristics curves for procalcitonin and C-reactive protein from the literature...
- ProBDNF induces neuronal apoptosis via activation of a receptor complex of p75NTR and sortilin
Henry K Teng
Department of Medicine, Weill Medical College of Cornell University, New York, New York 10021, USA
J Neurosci 25:5455-63. 2005
..Together with our past findings, these data suggest that the neurotrophin family is capable of modulating diverse biological processes via differential processing of the proneurotrophins...
- Procalcitonin to initiate or discontinue antibiotics in acute respiratory tract infections
Department of Emergency Medicine, Harvard School of Public Health, Boston, MA, USA
Cochrane Database Syst Rev 9:CD007498. 2012
- Procalcitonin to guide initiation and duration of antibiotic treatment in acute respiratory infections: an individual patient data meta-analysis
Department of Emergency Medicine, Beth Israel Deaconess Medical Center, and Harvard School of Public Health, Boston, MA 02115, USA
Clin Infect Dis 55:651-62. 2012
..We undertook an individual patient data meta-analysis to assess safety of this approach in different ARI diagnoses and different clinical settings...
- Accuracy of procalcitonin for sepsis diagnosis in critically ill patients: systematic review and meta-analysis
Benjamin M P Tang
Department of Intensive Care Medicine, Nepean Hospital, Penrith, New South Wales, Australia
Lancet Infect Dis 7:210-7. 2007
..The findings from this study do not lend support to the widespread use of the procalcitonin test in critical care settings...
- Lamin A-dependent misregulation of adult stem cells associated with accelerated ageing
National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
Nat Cell Biol 10:452-9. 2008
..Our results support a model in which accelerated ageing in HGPS patients, and possibly also physiological ageing, is the result of adult stem cell dysfunction and progressive deterioration of tissue functions...
- CTLs are targeted to kill beta cells in patients with type 1 diabetes through recognition of a glucose-regulated preproinsulin epitope
Department of Immunobiology, King s College London, London, United Kingdom
J Clin Invest 118:3390-402. 2008
..Our findings suggest that autoreactive CTLs are important targets for immune-based interventions in type 1 diabetes and argue for early, aggressive insulin therapy to preserve remaining beta cells...
- Enhancement of CURB65 score with proadrenomedullin (CURB65-A) for outcome prediction in lower respiratory tract infections: derivation of a clinical algorithm
Werner C Albrich
Medical University Department of the University of Basel, Kantonsspital Aarau, Switzerland
BMC Infect Dis 11:112. 2011
..We aimed to derive a practical algorithm combining the CURB65 score with ProADM-levels in patients with community-acquired pneumonia (CAP) and non-CAP-LRTI...
- Genomic instability in laminopathy-based premature aging
Department of Biochemistry, University of Hong Kong, 21 Sassoon Road, Hong Kong
Nat Med 11:780-5. 2005
..Our results indicate that unprocessed prelamin A and truncated lamin A act dominant negatively to perturb DNA damage response and repair, resulting in genomic instability which might contribute to laminopathy-based premature aging...
- Filaggrin in the frontline: role in skin barrier function and disease
Epithelial Genetics Group, Division of Molecular Medicine, Colleges of Life Sciences and Medicine, Dentistry and Nursing, University of Dundee, Dundee DD1 5EH, UK
J Cell Sci 122:1285-94. 2009
..Filaggrin is therefore in the frontline of defence, and protects the body from the entry of foreign environmental substances that can otherwise trigger aberrant immune responses...
- The ubiquitin-proteasome pathway is required for processing the NF-kappa B1 precursor protein and the activation of NF-kappa B
V J Palombella
Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138
Cell 78:773-85. 1994
..Thus, the ubiquitin-proteasome pathway functions not only in the complete degradation of polypeptides, but also in the regulated processing of precursors into active proteins...
- Sortilin is essential for proNGF-induced neuronal cell death
Department of Medical Biochemistry, Ole Worms Alle 170, Aarhus University, Gustav Wieds Vej 10, DK 8000 Aarhus C, Denmark
Nature 427:843-8. 2004
..Here we report that proNGF creates a signalling complex by simultaneously binding to p75NTR and sortilin. Thus sortilin acts as a co-receptor and molecular switch governing the p75NTR-mediated pro-apoptotic signal induced by proNGF...
- Effect of mutations affecting the p6 gag protein on human immunodeficiency virus particle release
H G Gottlinger
Dana Farber Cancer Institute, Department of Pathology, Harvard Medical School, Boston, MA 02115
Proc Natl Acad Sci U S A 88:3195-9. 1991
..Inhibition of the release of the viral capsid proteins by interferon alpha indicates that this step of virus maturation may be sensitive to inhibition by antiviral drugs...
- Translocation of proteins into mitochondria
Institut fur Physiologische Chemie, Universitat Munchen, 81377 Munchen, Germany
Annu Rev Biochem 76:723-49. 2007
..This review summarizes the present knowledge on the import and sorting of mitochondrial precursor proteins, with a special emphasis on unresolved questions and topics of current research...
- Histone H4 lysine 16 hypoacetylation is associated with defective DNA repair and premature senescence in Zmpste24-deficient mice
Department of Biochemistry, University of Hong Kong, Hong Kong
Proc Natl Acad Sci U S A 108:12325-30. 2011
..The above results shed light on how chromatin modifications regulate the DNA damage response and suggest that the reversal of epigenetic marks could make an attractive therapeutic target against laminopathy-based progeroid pathologies...
- A dual mechanism linking NGF/proNGF imbalance and early inflammation to Alzheimer's disease neurodegeneration in the AD11 anti-NGF mouse model
Scuola Normale Superiore, Pisa, Italy
CNS Neurol Disord Drug Targets 10:635-47. 2011
..Here, we will review (1) the renewed neurotrophic imbalance hypothesis for AD and (2) the mechanisms underlying the neurodegenerative phenotype of AD11 anti-NGF mice...
- Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-alpha
M L Moss
Department of Molecular Biochemistry, Glaxo Wellcome Research and Development Inc, Research Triangle Park, North Carolina 27709, USA
Nature 385:733-6. 1997
..The rTACE provides a readily available source of enzyme to help in the search for new anti-inflammatory agents that target the final processing stage of TNF-alpha production...
- L-DOPA-induced dyskinesia in the rat is associated with striatal overexpression of prodynorphin- and glutamic acid decarboxylase mRNA
M A Cenci
Wallenberg Neuroscience Center, Institute of Physiology and Neuroscience, University of Lund, 223 62 Lund, Sweden
Eur J Neurosci 10:2694-706. 1998
..Due to its treatment-dependent expression, and strong correlation with the associated dyskinetic symptoms, striatal PDyn mRNA, in particular, may play a role in the mechanisms of behavioural sensitization brought about by the drug...
- Procalcitonin assay in systemic inflammation, infection, and sepsis: clinical utility and limitations
Kenneth L Becker
Veterans Affairs Medical Center, Washington, DC, USA
Crit Care Med 36:941-52. 2008
..In particular, the need for a more sensitive assay will be emphasized. For these purposes, the medical literature comprising clinical studies pertaining to the measurement of serum ProCT in various clinical settings was examined...
- Predictive value of procalcitonin and interleukin 6 in critically ill patients with suspected sepsis
Department of Surgery, Division of Anesthesiology and Intensive Care Medicine, Helsinki University Hospital, P O Box 340, 00029 HUS, Helsinki, Finland
Intensive Care Med 28:1220-5. 2002
- Procalcitonin in sepsis and systemic inflammation: a harmful biomarker and a therapeutic target
Kenneth L Becker
George Washington University and Veterans Affairs Medical Center, Washington, DC 20422, USA
Br J Pharmacol 159:253-64. 2010
..An experimental groundwork has been established that suggests a potential applicability of such therapy in septic humans...
- Overlapping functions of components of a bacterial Sec-independent protein export pathway
Nitrogen Fixation Laboratory, John Innes Centre, Colney, Norwich NR4 7UH
EMBO J 17:3640-50. 1998
..A mutation previously assigned to the hcf106 homologue encoded at the tatABCD locus, mttA, lies instead in the tatB gene...
- Procalcitonin-guided interventions against infections to increase early appropriate antibiotics and improve survival in the intensive care unit: a randomized trial
Jens U Jensen
Copenhagen HIV Programme, University of Copenhagen, Copenhagen, Denmark
Crit Care Med 39:2048-58. 2011
..The objective of this trial was to determine whether a strategy of antimicrobial spectrum escalation, guided by daily measurements of the biomarker procalcitonin, could reduce the time to appropriate therapy, thus improving survival...
- Activation of p75NTR by proBDNF facilitates hippocampal long-term depression
Newton H Woo
Section on Neural Development and Plasticity, LCSN, NICHD, Porter Neuroscience Research Center, 35 Lincoln Drive, Bethesda, Maryland 20892 3714, USA
Nat Neurosci 8:1069-77. 2005
- Defective prelamin A processing and muscular and adipocyte alterations in Zmpste24 metalloproteinase-deficient mice
Alberto M Pendas
Departamento de Bioquimica y Biologia Molecular, Facultad de Medicina, Instituto Universitario de Oncologia, Universidad de Oviedo, 33006 Oviedo, Spain
Nat Genet 31:94-9. 2002
..These results indicate that prelamin A is a specific substrate for Zmpste24 and demonstrate the usefulness of genetic approaches for identifying the in vivo substrates of proteolytic enzymes...
- High prevalence and mapping of pre-S deletion in hepatitis B virus carriers with progressive liver diseases
Bing Fang Chen
School of Medicine, Fu Jen Catholic University, Taipei, Taiwan
Gastroenterology 130:1153-68. 2006
..The interactions among pre-S deletion, precore (PC) mutation, and basal core promoter (BCP) mutation in various stages of chronic hepatitis B virus (HBV) infection remain unclear and were thus investigated in this study...
- C-reactive protein and procalcitonin as predictors of survival and septic shock in ventilator-associated pneumonia
Dept of Respiratory and Critical Care Medicine, SOTIRIA Chest Diseases Hospital, Athens, Greece
Eur Respir J 35:805-11. 2010
..The only factor predicting the development of septic shock was SOFA on D1 (OR 7.44, 95% CI 1.330-5.715). Neither PCT and CRP threshold values nor their kinetics can predict VAP survival or septic shock development...
- Expanding the repertoire of amyloid polymorphs by co-polymerization of related protein precursors
Claire J Sarell
Astbury Centre for Structural Molecular Biology and School of Molecular and Cellular Biology, University of Leeds, Leeds LS2 9JT, United Kingdom
J Biol Chem 288:7327-37. 2013
- Pre-S mutant surface antigens in chronic hepatitis B virus infection induce oxidative stress and DNA damage
Yi Hsuan Hsieh
Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan 70101, Taiwan
Carcinogenesis 25:2023-32. 2004
..These results indicate that pre-S1/S2 mutant HBsAg, which make up GGHs, induce oxidative DNA damage and mutations in hepatocytes in the late stages of HBV infection...
- Circulating preproinsulin signal peptide-specific CD8 T cells restricted by the susceptibility molecule HLA-A24 are expanded at onset of type 1 diabetes and kill β-cells
National Institute for Health Research Comprehensive Biomedical Research Centre at Guy s and St Thomas National Health Service Foundation Trust and King s College London, London, UK
Diabetes 61:1752-9. 2012
..PPI-specific, HLA-A24-restricted CD8 T cells are expanded in patients with recent-onset disease. Human islet cells process and present PPI(3-11), rendering themselves targets for CTL-mediated killing...
- Biomarkers in respiratory tract infections: diagnostic guides to antibiotic prescription, prognostic markers and mediators
Department of Internal Medicine, University Hospital Basel, Petersgraben 4, CH 4031 Basel, Switzerland
Eur Respir J 30:556-73. 2007
..In several animal models the modulation and neutralisation of hormokines during infection was shown to improve survival, and thus might open new treatment options for severe infections, especially of the respiratory tract...
- Alpha-fetoprotein, des-gamma carboxyprothrombin, and lectin-bound alpha-fetoprotein in early hepatocellular carcinoma
Jorge A Marrero
University of Michigan, Ann Arbor, Michigan 48109, USA
Gastroenterology 137:110-8. 2009
..The aims of this study were to determine performance of DCP and AFP-L3% for the diagnosis of early HCC; whether they complement AFP; and what factors affect DCP, AFP-L3%, or AFP levels...
- Targeted deletion of the tachykinin 4 gene (TAC4-/-) influences the early stages of B lymphocyte development
Division of Stem Cell and Developmental Biology, Ontario Cancer Institute, Princess Margaret Hospital, Toronto, ON, Canada
Blood 116:3792-801. 2010
- Procalcitonin behaves as a fast responding acute phase protein in vivo and in vitro
M W Nijsten
Department of Surgery, University Hospital Groningen, and the Groningen Institute for Drug Studies, The Netherlands
Crit Care Med 28:458-61. 2000
..The source of production and its mechanism of induction are unknown. We investigated the inducibility of PCT both in vivo and in vitro and compared the behavior of PCT with those of SAA and CRP...
- The role of procalcitonin in febrile neutropenic patients: review of the literature
Department of Anaesthesiology and Intensive Care, Friedrich Schiller University, Erlanger Allee 103, Jena, Germany
Infection 36:396-407. 2008
- Utility of procalcitonin concentration in the evaluation of patients with malignant diseases and elevated C-reactive protein plasma concentrations
Department of Hematology Oncology, University of Gottingen, Gottingen, Germany
Clin Infect Dis 43:468-73. 2006
..Elevated plasma concentrations of the C-reactive protein (CRP) are frequently found in patients with malignant diseases. Discrimination between infection and noninfectious acute-phase reactions is essential for therapeutic decisions...
- Envoplakin, a novel precursor of the cornified envelope that has homology to desmoplakin
Keratinocyte Laboratory, Imperial Cancer Research Fund, London, United Kingdom
J Cell Biol 134:715-29. 1996
..These data suggest that the 210-kD protein may link the cornified envelope to desmosomes and keratin filaments. We propose that the 210-kD protein be named "envoplakin."..
- Serum levels of C-reactive protein and procalcitonin in critically ill patients with cirrhosis of the liver
Daliana Peres Bota
Department of Intensive Care, Erasme Hospital, Free University of Brussels, Brussels, Belgium
J Lab Clin Med 146:347-51. 2005
..Moreover, the predictive power of CRP and PCT for infection was similar for patients with and without cirrhosis...
- Mono- and dibasic proteolytic cleavage sites in insect neuroendocrine peptide precursors
J A Veenstra
Laboratoire de Neuroendocrinologie, Universite Bordeaux I, Talence, France
Arch Insect Biochem Physiol 43:49-63. 2000
..Arch. Insect Biochem. Physiol. 43:49-63, 2000...
- The plasma elimination rate and urinary secretion of procalcitonin in patients with normal and impaired renal function
Department of Anaesthesiology and Intensive Care Therapy, University of Jena, Bachstr. 18, D-07743 Jena, Germany
Eur J Anaesthesiol 18:79-87. 2001
..We conclude that procalcitonin can be used diagnostically in patients with renal failure as well as in those with normal renal function...
- Pre-S deletion and complex mutations of hepatitis B virus related to advanced liver disease in HBeAg-negative patients
Chien Hung Chen
Division of Hepatogastroenterology, Department of Internal Medicine, Chang Gung Memorial Hospital Kaohsiung Medical Center, Kaohsiung, Taiwan
Gastroenterology 133:1466-74. 2007
- Procalcitonin for guidance of antibiotic therapy
Harvard School of Public Health, MA, USA
Expert Rev Anti Infect Ther 8:575-87. 2010
..This review aims to provide physicians with an overview of the strengths and limitations of procalcitonin guidance for antibiotic therapy when used in different clinical settings and in patients with different underlying infections...
- Alterations of nuclear envelope and chromatin organization in mandibuloacral dysplasia, a rare form of laminopathy
Laboratory of Clinical Biochemistry and Department of Neuroscience, University of Roma Tor Vergata, Rome, Italy
Physiol Genomics 23:150-8. 2005
..These results strongly suggest that altered chromatin remodeling is a key event in the cascade of epigenetic events causing MADA and could be related to the premature-aging phenotype...
- The nerve growth factor precursor proNGF exhibits neurotrophic activity but is less active than mature nerve growth factor
Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario, Canada
J Neurochem 89:581-92. 2004
..These data, coupled with our previous report that proNGF is the major form of NGF in the CNS, suggest that proNGF could be responsible for much of the biological activity normally attributed to mature NGF in vivo...
- Structural determinants of cadherin-23 function in hearing and deafness
Howard Hughes Medical Institute, Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA
Neuron 66:85-100. 2010
..The structures define an uncharacterized cadherin family and, with simulations, suggest mechanisms underlying inherited deafness and how cadherin-23 may bind with itself and with protocadherin-15 to form the tip link...
- Mutations of keratinocyte transglutaminase in lamellar ichthyosis
Department of Dermatology, Centre Hospitalier Universitaire Vandois CHUV, Hôpital de Beaumont, Lausanne, Switzerland
Science 267:525-8. 1995
..These data suggest that defects in TGK cause lamellar ichthyosis and that intact cross-linkage of cornified cell envelopes is required for epidermal tissue homeostasis...
- Distinctive roles of PHAP proteins and prothymosin-alpha in a death regulatory pathway
Howard Hughes Medical Institute, Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
Science 299:223-6. 2003
..Thus, this chemical-biological combinatory approach has revealed the regulatory roles of oncoprotein ProT and tumor suppressor PHAP in apoptosis...
- Viral and cellular determinants involved in hepadnaviral entry
Institute of Medical Virology, Justus Liebig University of Giessen, Frankfurter Strasse 107, D 35392 Giessen, Germany
World J Gastroenterol 13:22-38. 2007
..g. test the fitness of escape mutants), (3) titrate and map neutralizing antibodies, (4) improve current vaccines to combat acute and chronic infections of hepatitis B, and (5) develop entry inhibitors for future clinical applications...
- Cholinergic involvement in Alzheimer's disease. A link with NGF maturation and degradation
A Claudio Cuello
Department of Pharmacology and Therapeutics, McGill University, Montreal, QC, H3G 1Y6, Canada
J Mol Neurosci 40:230-5. 2010
- Procalcitonin for diagnosis of infection and guide to antibiotic decisions: past, present and future
Harvard School of Public Health, 667 Huntington Ave, 02115 Boston MA, USA
BMC Med 9:107. 2011
..The aim of this review is to summarize the current evidence for PCT in different infections and clinical settings, and discuss the reliability of this marker when used with validated diagnostic algorithms...
- Effect of procalcitonin-guided treatment in patients with infections: a systematic review and meta-analysis
Intensive Care Unit, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Zhejiang, People s Republic of China
Infection 37:497-507. 2009
- Procalcitonin-guided algorithms of antibiotic therapy in the intensive care unit: a systematic review and meta-analysis of randomized controlled trials
Second Critical Care Department, Attiko University Hospital, University of Athens Medical School, Athens, Greece
Crit Care Med 38:2229-41. 2010
..We sought to determine the effectiveness and safety of procalcitonin-guided algorithms in the management of septic patients in the intensive care unit...
- Progerin and telomere dysfunction collaborate to trigger cellular senescence in normal human fibroblasts
Genome Technology Branch, National Human Genome Research Institute, NIH, Bethesda, Maryland 20892 0148, USA
J Clin Invest 121:2833-44. 2011
- Procalcitonin algorithms for antibiotic therapy decisions: a systematic review of randomized controlled trials and recommendations for clinical algorithms
Department of Emergency Medicine, Harvard School of Public Health, Boston, MA 02115, USA
Arch Intern Med 171:1322-31. 2011
..We propose specific procalcitonin algorithms for low-, moderate-, and high-acuity patients as a basis for future trials aiming at reducing antibiotic overconsumption...
- Dissection of the mitochondrial import and assembly pathway for human Tom40
Adam D Humphries
Department of Biochemistry, La Trobe University, Melbourne 3086, Australia
J Biol Chem 280:11535-43. 2005
..Nevertheless, we show that Tom40 assembly is reduced in mitochondria depleted of human Sam50. These findings are discussed in context with current models from fungal studies...
- Procalcitonin and C-reactive protein during systemic inflammatory response syndrome, sepsis and organ dysfunction
Gian Paolo Castelli
Intensive Care, Anesthesiology and Pain Relief Unit, C Poma Hospital, Mantova, Italy
Crit Care 8:R234-42. 2004
..We hypothesised that PCT and CRP concentrations are different in patients with infection or with no infection at a similar severity of organ dysfunction or of systemic inflammatory response...
- Mutations of the protocadherin gene PCDH15 cause Usher syndrome type 1F
Z M Ahmed
Laboratory of Molecular Genetics, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, 5 Research Court, Rockville, MD, USA
Am J Hum Genet 69:25-34. 2001
..A Northern blot probed with the PCDH15 cytoplasmic domain showed expression in the retina, consistent with its pathogenetic role in the retinitis pigmentosa associated with USH1F...
- Diagnostic and prognostic accuracy of clinical and laboratory parameters in community-acquired pneumonia
Departments of Internal Medicine, University Hospital, Petersgraben 4, CH 4031, Basel, Switzerland
BMC Infect Dis 7:10. 2007
..This study aims to evaluate the diagnostic and prognostic accuracy of clinical signs and symptoms and laboratory biomarkers for CAP...
- Human lipodystrophies linked to mutations in A-type lamins and to HIV protease inhibitor therapy are both associated with prelamin A accumulation, oxidative stress and premature cellular senescence
INSERM U680, Universite Pierre et Marie Curie Paris 6, Faculte de Medecine, site Saint Antoine, 27 rue Chaligny, 75571 Paris Cedex 12, France
Cell Death Differ 14:1759-67. 2007
..These alterations could participate in the pathophysiology of lipodystrophic syndromes and lead to premature ageing complications...
- Multiple functions of precursor BDNF to CNS neurons: negative regulation of neurite growth, spine formation and cell survival
National Institute of Advanced Industrial Science and Technology AIST, Ikeda, 563 8577 Japan
Mol Brain 2:27. 2009
- Procalcitonin for reduced antibiotic exposure in ventilator-associated pneumonia: a randomised study
Clinic of Pulmonary Medicine and Respiratory Cell Research, University Hospital, Petersgraben 4, CH 4031 Basel, Switzerland
Eur Respir J 34:1364-75. 2009
..Serum procalcitonin reduces antibiotic therapy exposure in patients with ventilator associated pneumonia...
- Plasma procalcitonin and the risk of cardiovascular events and death: a prospective population-based study
Department of Clinical Sciences, Lund University, Skåne University Hospital Malmö, Malmo, Sweden
J Intern Med 272:484-91. 2012
..We evaluated the ability of PCT to predict future cardiovascular events in a population of apparently healthy individuals...
- Different types of ground glass hepatocytes in chronic hepatitis B virus infection contain specific pre-S mutants that may induce endoplasmic reticulum stress
Hui Ching Wang
Graduate Institutes of Basic Medical Sciences, Molecular Medicine, and Immunology and Microbiology, National Cheng Kung University College of Medicine, Tainan, Taiwan
Am J Pathol 163:2441-9. 2003
..This study therefore demonstrates that different GGHs may contain specific mutants and exhibit differential biological activities...
- Cadherin 23 and protocadherin 15 interact to form tip-link filaments in sensory hair cells
The Scripps Research, Institute Department of Cell Biology, La Jolla, California 92037, USA
Nature 449:87-91. 2007
..Our studies define the molecular composition of tip links and provide a conceptual base for exploring the mechanisms of sensory impairment associated with mutations in CDH23 and PCDH15...
- Pro-NGF, sortilin, and p75NTR: potential mediators of injury-induced apoptosis in the mouse dorsal root ganglion
Melinda G Arnett
Department of Anatomy and Cell Biology, University of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City, KS 66160, USA
Brain Res 1183:32-42. 2007
..These results propose pro-NGF-induced, p75NTR-sortilin-mediated neuronal death as a critical aspect of nerve injury-induced death in the DRG...
- Biological activity of nerve growth factor precursor is dependent upon relative levels of its receptors
Department of Biology, McMaster University, Hamilton, Ontario L8N 3Z5, Canada
J Biol Chem 284:18424-33. 2009
..We conclude that the relative level of proNGF receptors determines whether this precursor exhibits neurotrophic or apoptotic activity...
- Thyroid-stimulating hormone, a novel, locally produced modulator of human epidermal functions, is regulated by thyrotropin-releasing hormone and thyroid hormones
Department of Dermatology, University of Lubeck, Ratzeburger Allee 160, D 23538 Lubeck, Germany
Endocrinology 151:1633-42. 2010
..Intraepidermal TSH expression appears to be regulated by the classical endocrine controls that determine the systemic HPT axis...
- Distinct expression of Cbln family mRNAs in developing and adult mouse brains
Department of Anatomy, Hokkaido University School of Medicine, Sapporo 060 8638, Japan
Eur J Neurosci 24:750-60. 2006
..These results will provide a molecular-anatomical basis for future studies that characterize roles played by the Cbln family...
- Pro-nerve growth factor induces autocrine stimulation of breast cancer cell invasion through tropomyosin-related kinase A (TrkA) and sortilin protein
INSERM U908 Growth Factor Signaling in Breast Cancer, University of Lille, Villeneuve d Ascq 59655, France
J Biol Chem 287:1923-31. 2012
..These data reveal the existence of an autocrine loop stimulated by proNGF and mediated by TrkA and sortilin, with the activation of Akt and Src, for the stimulation of breast cancer cell invasion...
- In vitro and in vivo calcitonin I gene expression in parenchymal cells: a novel product of human adipose tissue
Department of Research, University Hospitals, Hebelstrasse 20, 4031 Basel, Switzerland
Endocrinology 144:5578-84. 2003
..The inhibiting effect of IFNgamma on IL-1beta-induced CT mRNA expression and on ProCT secretion might explain previous observations that serum ProCT concentrations increase less in systemic viral compared with bacterial infections...
- Regulation of PCDH15 function in mechanosensory hair cells by alternative splicing of the cytoplasmic domain
Stuart W Webb
Dorris Neuroscience Center and Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
Development 138:1607-17. 2011
..Our findings reveal an essential role for PCDH15-CD2 in the formation of kinociliary links and hair bundle polarization, and show that several PCDH15 isoforms can function redundantly at tip links...
- Comparison of procalcitonin and C-reactive protein as markers of sepsis
Institute of Anesthesiology and Intensive Care, University Hospital, Verona, Italy
Crit Care Med 31:1737-41. 2003
..To compare the clinical informative value of procalcitonin (PCT) and C-reactive protein (CRP) plasma concentrations in the detection of infection and sepsis and in the assessment of severity of sepsis...
- Regulation of apoptosis by the p8/prothymosin alpha complex
Institut National de la Santé et de la Recherche Médicale Unité 624, Stress Cellulaire, 163 Avenue de Luminy, Case 915, Parc Scientifique et Technologique de Luminy, 13288 Marseille Cedex 9, France
Proc Natl Acad Sci U S A 103:2671-6. 2006
..These results strongly suggest that the antiapoptotic response of HeLa cells upon staurosporine treatment requires expression of both p8 and ProTalpha...
- Functional cross-talk between beta-catenin and NFkappaB signaling pathways in colonic crypts of mice in response to progastrin
Department of Internal Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
J Biol Chem 284:22274-84. 2009
..Our studies suggest a novel possibility that activation of beta-catenin, downstream to the IKKalpha,beta/NFkappaB pathway, may be integral to the hyperproliferative effects of progastrin on proximal colonic crypts...
- Early decrease in α-fetoprotein, but not des-γ-carboxy prothrombin, predicts sorafenib efficacy in patients with advanced hepatocellular carcinoma
Division of Gastroenterology and Hepatology, Musashino Red Cross Hospital, Musashino, Tokyo, Japan
Oncology 81:251-8. 2011
- Latent transforming growth factor-beta 1 and its binding protein are components of extracellular matrix microfibrils
Departments of Virology, University of Helsinki, Finland
J Histochem Cytochem 44:875-89. 1996
..The present results indicate that latent TGF-beta 1 complexes are components of the extracellular matrix and suggest that alterations of the pericellular matrix could result in aberrant TGF-beta signaling...
- ProNGF mediates death of Natural Killer cells through activation of the p75NTR-sortilin complex
Mary Louise Rogers
Department of Human Physiology, School of Medicine, Flinders University, GPO Box 2100 Adelaide 5001, Australia
J Neuroimmunol 226:93-103. 2010
..This was reduced by blocking sortilin with neurotensin. We conclude that proNGF induced apoptosis of NK cells may have important implications for limiting the innate immune response...
- Significance of alpha-fetoprotein and des-gamma-carboxy prothrombin in patients with hepatocellular carcinoma undergoing hepatectomy
Department of Surgery, Hepato Biliary Pancreatic Surgery Division, Artificial Organ and Transplantation Division, University of Tokyo, Tokyo, Japan
Ann Surg Oncol 16:2795-804. 2009
- Procalcitonin as an early marker of infection in neonates and children
A M C van Rossum
Medical Centre Rijnmond Zuid, Rotterdam, Netherlands
Lancet Infect Dis 4:620-30. 2004
..Procalcitonin is therefore a useful additional tool for the diagnosis of bacterial disease in neonates and children...
- Optimised patient transfer using an innovative multidisciplinary assessment in Kanton Aargau (OPTIMA I): an observational survey in lower respiratory tract infections
W C Albrich
Medical University Department of the University of Basel, Kantonsspital Aarau, Tellstrasse, CH
Swiss Med Wkly 141:w13237. 2011
..We describe our current triage practice and assess the potential of a combination of CURB65 with proadrenomedullin (ProADM) levels for triage decisions...
- Use of plasma C-reactive protein, procalcitonin, neutrophils, macrophage migration inhibitory factor, soluble urokinase-type plasminogen activator receptor, and soluble triggering receptor expressed on myeloid cells-1 in combination to diagnose infections
Clinical Research Unit, Copenhagen University Hospital, Hvidovre, Kettegaard Alle 30, DK 2650 Hvidovre, Denmark
Crit Care 11:R38. 2007
..Combinations of markers, as opposed to single ones, may improve diagnosis and thereby survival. We therefore compared the diagnostic characteristics of novel and routinely used biomarkers of sepsis alone and in combination...
- Involvement of prelamin A in laminopathies
N M Maraldi
Laboratory of Cell Biology, Istituto Ortopedico Rizzoli, Bologna, Italy
Crit Rev Eukaryot Gene Expr 17:317-34. 2007
- NG peptides: a novel family of neurophysin-associated neuropeptides
Maurice R Elphick
Queen Mary University of London, School of Biological and Chemical Sciences, Mile End Road, London, E1 4NS, UK
Gene 458:20-6. 2010
- Uptake and recycling of pro-BDNF for transmitter-induced secretion by cortical astrocytes
Department of Human and General Physiology, University of Bologna, I 40126 Bologna, Italy
J Cell Biol 183:213-21. 2008
..Thus, astrocytes contain an endocytic compartment competent for pro-BDNF recycling, suggesting a specialized form of bidirectional communication between neurons and glia...
- Serum procalcitonin and other biologic markers to distinguish between bacterial and aseptic meningitis
Clinical Epidemiology Unit, Department of Pediatrics, Saint Vincent de Paul Hospital, AP HP, Paris Descartes University, and INSERM U149, Paris, France
J Pediatr 149:72-6. 2006
..To identify the biologic tests that best distinguish between bacterial and aseptic meningitis in an emergency department (ED)...
- Plastid proteome assembly without Toc159: photosynthetic protein import and accumulation of N-acetylated plastid precursor proteins
Department of Biology, Eidgenossische Technische Hochschule Zurich, 8092 Zurich, Switzerland
Plant Cell 23:3911-28. 2011
- Procalcitonin and C-reactive protein in hospitalized adult patients with community-acquired pneumonia or exacerbation of asthma or COPD
Institute for Lung Health, University of Leicester, Leicester, England
Chest 139:1410-8. 2011
..We aimed to compare the usefulness of the biomarkers procalcitonin and C-reactive protein (CRP) in patients with pneumonia or exacerbations of asthma or COPD...
- Cutting edge: cyclic polypeptide and aminoglycoside antibiotics trigger IL-1β secretion by activating the NLRP3 inflammasome
Medizinische Poliklinik, Universitat Munchen, Munich, Germany
J Immunol 186:2714-8. 2011
..All four antibiotics induced neutrophil influx into the peritoneal cavity of mice, which required NLRP3 only in the case of polymyxin B. Together, certain antibiotics have the potential to directly activate innate immunity of the host...
- Multiple precursor proteins bind individual Tat receptor complexes and are collectively transported
Horticultural Sciences Department and Plant Molecular and Cellular Biology, University of Florida, Gainesville, FL, USA
EMBO J 29:1477-88. 2010
..These results imply a novel aspect of Tat systems, whereby multiple precursor-binding sites can act in concert to transport an interlinked oligo-precursor protein...
- Proneurotrophin-3 may induce Sortilin-dependent death in inner ear neurons
Department of Otorhinolaryngology, Aarhus University Hospital, Nørrebrogade 44, 8000 Aarhus C, Denmark
Eur J Neurosci 33:622-31. 2011
..However, our results suggest that proNT3 and proBDNF may play important roles in the response to noise-induced injuries or ototoxic damage via the Sortilin:p75(NTR) death-signalling complex...
- Double homozygous waltzer and Ames waltzer mice provide no evidence of retinal degeneration
Zubair M Ahmed
National Institute on Deafness and Other Communication Disorders, NIH, Rockville, MD 20850, USA
Mol Vis 14:2227-36. 2008
..Does homozygosity for both v and av mutant alleles (i.e., a double homozygous mouse) cause retinal degeneration or an obvious retinal histopathology?..
- Serum procalcitonin at the time of admission to the ICU as a predictor of short-term mortality
Fan Su Meng
ICU, General Hospital of Guangzhou Military Command, 111 Liu Hua Road, Yue Xiu District, Guangzhou, China
Clin Biochem 42:1025-31. 2009
..This purpose of this study was to determine if serum procalcitonin (PCT) concentration at the time of admission to the ICU is a predictor of all-cause short-term mortality...
- Comparison of thromboelastometry with procalcitonin, interleukin 6, and C-reactive protein as diagnostic tests for severe sepsis in critically ill adults
Klinik für Anästhesiologie und Intensivmedizin, Universitätsklinikum Essen und Universität Duisburg Essen, Hufelandstr, 55, 45130 Essen, Germany
Crit Care 14:R178. 2010
..We investigated whether thromboelastometry variables are suitable as biomarkers for severe sepsis in critically ill adults...
- Early detection of an early onset infection in the neonate based on measurements of procalcitonin and C-reactive protein concentrations in cord blood
Pomeranian Medical University, Szczecin, Poland
Clin Chem Lab Med 46:1143-8. 2008
- Des-gamma-carboxyprothrombin, alpha-fetoprotein and AFP-L3 in patients with chronic hepatitis, cirrhosis and hepatocellular carcinoma
Francisco A Durazo
The Pfleger Liver Institute, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
J Gastroenterol Hepatol 23:1541-8. 2008
- Prediction about severity and outcome of sepsis by pro-atrial natriuretic peptide and pro-adrenomedullin
Rui lan Wang
First People s Hospital, Shanghai Jiaotong University, China
Chin J Traumatol 13:152-7. 2010
- Prognostic values of alpha-fetoprotein and protein induced by vitamin K absence or antagonist-II in hepatitis B virus-related hepatocellular carcinoma: a prospective study
Hyoung Su Kim
Department of Internal Medicine, Kangdong Sacred Heart Hospital of Hallym University Medical Center, Seoul, Republic of Korea
J Clin Gastroenterol 43:482-8. 2009
..However, prognostic values of AFP and PIVKA-II remain clarified in hepatitis B virus (HBV)-associated HCC. This study was aimed to evaluate the prognostic values of AFP and PIVKA-II in HBV-associated HCC...