protein precursors

Summary

Top Publications

  1. ncbi Regulation of cell survival by secreted proneurotrophins
    R Lee
    Division of Hematology, Department of Medicine, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
    Science 294:1945-8. 2001
  2. ncbi Effect of procalcitonin-based guidelines vs standard guidelines on antibiotic use in lower respiratory tract infections: the ProHOSP randomized controlled trial
    Philipp Schuetz
    Department of Internal Medicine, Kantonsspital Aarau, Tellstrasse, CH 5001 Aarau, Switzerland
    JAMA 302:1059-66. 2009
  3. ncbi Cleavage of proBDNF by tPA/plasmin is essential for long-term hippocampal plasticity
    Petti T Pang
    Section on Neural Development and Plasticity, Laboratory of Cellular and Synaptic Neurophysiology, National Institute of Child Health and Human Development NICHD, Bethesda, MD 20892, USA
    Science 306:487-91. 2004
  4. ncbi Assay for the measurement of copeptin, a stable peptide derived from the precursor of vasopressin
    Nils G Morgenthaler
    Research Department, B R A H M S AG, Biotechnology Centre Hennigsdorf Berlin, Germany
    Clin Chem 52:112-9. 2006
  5. ncbi Procalcitonin as a diagnostic test for sepsis in critically ill adults and after surgery or trauma: a systematic review and meta-analysis
    Bernard Uzzan
    APHP Laboratoire de Pharmacologie Hormonologie, Hopital Avicenne, Bobigny, France
    Crit Care Med 34:1996-2003. 2006
  6. ncbi ProBDNF induces neuronal apoptosis via activation of a receptor complex of p75NTR and sortilin
    Henry K Teng
    Department of Medicine, Weill Medical College of Cornell University, New York, New York 10021, USA
    J Neurosci 25:5455-63. 2005
  7. ncbi Procalcitonin to initiate or discontinue antibiotics in acute respiratory tract infections
    Philipp Schuetz
    Department of Emergency Medicine, Harvard School of Public Health, Boston, MA, USA
    Cochrane Database Syst Rev 9:CD007498. 2012
  8. pmc Procalcitonin to guide initiation and duration of antibiotic treatment in acute respiratory infections: an individual patient data meta-analysis
    Philipp Schuetz
    Department of Emergency Medicine, Beth Israel Deaconess Medical Center, and Harvard School of Public Health, Boston, MA 02115, USA
    Clin Infect Dis 55:651-62. 2012
  9. ncbi Accuracy of procalcitonin for sepsis diagnosis in critically ill patients: systematic review and meta-analysis
    Benjamin M P Tang
    Department of Intensive Care Medicine, Nepean Hospital, Penrith, New South Wales, Australia
    Lancet Infect Dis 7:210-7. 2007
  10. pmc Lamin A-dependent misregulation of adult stem cells associated with accelerated ageing
    Paola Scaffidi
    National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
    Nat Cell Biol 10:452-9. 2008

Detail Information

Publications278 found, 100 shown here

  1. ncbi Regulation of cell survival by secreted proneurotrophins
    R Lee
    Division of Hematology, Department of Medicine, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
    Science 294:1945-8. 2001
    ..The biological action of neurotrophins is thus regulated by proteolytic cleavage, with proforms preferentially activating p75NTR to mediate apoptosis and mature forms activating Trk receptors to promote survival...
  2. ncbi Effect of procalcitonin-based guidelines vs standard guidelines on antibiotic use in lower respiratory tract infections: the ProHOSP randomized controlled trial
    Philipp Schuetz
    Department of Internal Medicine, Kantonsspital Aarau, Tellstrasse, CH 5001 Aarau, Switzerland
    JAMA 302:1059-66. 2009
    ..In previous smaller trials, a procalcitonin (PCT) algorithm reduced antibiotic use in patients with lower respiratory tract infections (LRTIs)...
  3. ncbi Cleavage of proBDNF by tPA/plasmin is essential for long-term hippocampal plasticity
    Petti T Pang
    Section on Neural Development and Plasticity, Laboratory of Cellular and Synaptic Neurophysiology, National Institute of Child Health and Human Development NICHD, Bethesda, MD 20892, USA
    Science 306:487-91. 2004
    ..Moreover, application of mBDNF is sufficient to rescue L-LTP when protein synthesis is inhibited, which suggests that mBDNF is a key protein synthesis product for L-LTP expression...
  4. ncbi Assay for the measurement of copeptin, a stable peptide derived from the precursor of vasopressin
    Nils G Morgenthaler
    Research Department, B R A H M S AG, Biotechnology Centre Hennigsdorf Berlin, Germany
    Clin Chem 52:112-9. 2006
    ..We present a method for quantifying AVP release by use of copeptin, a glycopeptide comprising the C-terminal part of the AVP prohormone...
  5. ncbi Procalcitonin as a diagnostic test for sepsis in critically ill adults and after surgery or trauma: a systematic review and meta-analysis
    Bernard Uzzan
    APHP Laboratoire de Pharmacologie Hormonologie, Hopital Avicenne, Bobigny, France
    Crit Care Med 34:1996-2003. 2006
    ..To draw and compare the summary receiver operating characteristics curves for procalcitonin and C-reactive protein from the literature...
  6. ncbi ProBDNF induces neuronal apoptosis via activation of a receptor complex of p75NTR and sortilin
    Henry K Teng
    Department of Medicine, Weill Medical College of Cornell University, New York, New York 10021, USA
    J Neurosci 25:5455-63. 2005
    ..Together with our past findings, these data suggest that the neurotrophin family is capable of modulating diverse biological processes via differential processing of the proneurotrophins...
  7. ncbi Procalcitonin to initiate or discontinue antibiotics in acute respiratory tract infections
    Philipp Schuetz
    Department of Emergency Medicine, Harvard School of Public Health, Boston, MA, USA
    Cochrane Database Syst Rev 9:CD007498. 2012
    ....
  8. pmc Procalcitonin to guide initiation and duration of antibiotic treatment in acute respiratory infections: an individual patient data meta-analysis
    Philipp Schuetz
    Department of Emergency Medicine, Beth Israel Deaconess Medical Center, and Harvard School of Public Health, Boston, MA 02115, USA
    Clin Infect Dis 55:651-62. 2012
    ..We undertook an individual patient data meta-analysis to assess safety of this approach in different ARI diagnoses and different clinical settings...
  9. ncbi Accuracy of procalcitonin for sepsis diagnosis in critically ill patients: systematic review and meta-analysis
    Benjamin M P Tang
    Department of Intensive Care Medicine, Nepean Hospital, Penrith, New South Wales, Australia
    Lancet Infect Dis 7:210-7. 2007
    ..The findings from this study do not lend support to the widespread use of the procalcitonin test in critical care settings...
  10. pmc Lamin A-dependent misregulation of adult stem cells associated with accelerated ageing
    Paola Scaffidi
    National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
    Nat Cell Biol 10:452-9. 2008
    ..Our results support a model in which accelerated ageing in HGPS patients, and possibly also physiological ageing, is the result of adult stem cell dysfunction and progressive deterioration of tissue functions...
  11. pmc CTLs are targeted to kill beta cells in patients with type 1 diabetes through recognition of a glucose-regulated preproinsulin epitope
    Ania Skowera
    Department of Immunobiology, King s College London, London, United Kingdom
    J Clin Invest 118:3390-402. 2008
    ..Our findings suggest that autoreactive CTLs are important targets for immune-based interventions in type 1 diabetes and argue for early, aggressive insulin therapy to preserve remaining beta cells...
  12. pmc Enhancement of CURB65 score with proadrenomedullin (CURB65-A) for outcome prediction in lower respiratory tract infections: derivation of a clinical algorithm
    Werner C Albrich
    Medical University Department of the University of Basel, Kantonsspital Aarau, Switzerland
    BMC Infect Dis 11:112. 2011
    ..We aimed to derive a practical algorithm combining the CURB65 score with ProADM-levels in patients with community-acquired pneumonia (CAP) and non-CAP-LRTI...
  13. ncbi Genomic instability in laminopathy-based premature aging
    Baohua Liu
    Department of Biochemistry, University of Hong Kong, 21 Sassoon Road, Hong Kong
    Nat Med 11:780-5. 2005
    ..Our results indicate that unprocessed prelamin A and truncated lamin A act dominant negatively to perturb DNA damage response and repair, resulting in genomic instability which might contribute to laminopathy-based premature aging...
  14. pmc Filaggrin in the frontline: role in skin barrier function and disease
    Aileen Sandilands
    Epithelial Genetics Group, Division of Molecular Medicine, Colleges of Life Sciences and Medicine, Dentistry and Nursing, University of Dundee, Dundee DD1 5EH, UK
    J Cell Sci 122:1285-94. 2009
    ..Filaggrin is therefore in the frontline of defence, and protects the body from the entry of foreign environmental substances that can otherwise trigger aberrant immune responses...
  15. ncbi The ubiquitin-proteasome pathway is required for processing the NF-kappa B1 precursor protein and the activation of NF-kappa B
    V J Palombella
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138
    Cell 78:773-85. 1994
    ..Thus, the ubiquitin-proteasome pathway functions not only in the complete degradation of polypeptides, but also in the regulated processing of precursors into active proteins...
  16. ncbi Sortilin is essential for proNGF-induced neuronal cell death
    Anders Nykjaer
    Department of Medical Biochemistry, Ole Worms Alle 170, Aarhus University, Gustav Wieds Vej 10, DK 8000 Aarhus C, Denmark
    Nature 427:843-8. 2004
    ..Here we report that proNGF creates a signalling complex by simultaneously binding to p75NTR and sortilin. Thus sortilin acts as a co-receptor and molecular switch governing the p75NTR-mediated pro-apoptotic signal induced by proNGF...
  17. pmc Effect of mutations affecting the p6 gag protein on human immunodeficiency virus particle release
    H G Gottlinger
    Dana Farber Cancer Institute, Department of Pathology, Harvard Medical School, Boston, MA 02115
    Proc Natl Acad Sci U S A 88:3195-9. 1991
    ..Inhibition of the release of the viral capsid proteins by interferon alpha indicates that this step of virus maturation may be sensitive to inhibition by antiviral drugs...
  18. ncbi Translocation of proteins into mitochondria
    Walter Neupert
    Institut fur Physiologische Chemie, Universitat Munchen, 81377 Munchen, Germany
    Annu Rev Biochem 76:723-49. 2007
    ..This review summarizes the present knowledge on the import and sorting of mitochondrial precursor proteins, with a special emphasis on unresolved questions and topics of current research...
  19. pmc Histone H4 lysine 16 hypoacetylation is associated with defective DNA repair and premature senescence in Zmpste24-deficient mice
    Vaidehi Krishnan
    Department of Biochemistry, University of Hong Kong, Hong Kong
    Proc Natl Acad Sci U S A 108:12325-30. 2011
    ..The above results shed light on how chromatin modifications regulate the DNA damage response and suggest that the reversal of epigenetic marks could make an attractive therapeutic target against laminopathy-based progeroid pathologies...
  20. ncbi A dual mechanism linking NGF/proNGF imbalance and early inflammation to Alzheimer's disease neurodegeneration in the AD11 anti-NGF mouse model
    S Capsoni
    Scuola Normale Superiore, Pisa, Italy
    CNS Neurol Disord Drug Targets 10:635-47. 2011
    ..Here, we will review (1) the renewed neurotrophic imbalance hypothesis for AD and (2) the mechanisms underlying the neurodegenerative phenotype of AD11 anti-NGF mice...
  21. ncbi Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-alpha
    M L Moss
    Department of Molecular Biochemistry, Glaxo Wellcome Research and Development Inc, Research Triangle Park, North Carolina 27709, USA
    Nature 385:733-6. 1997
    ..The rTACE provides a readily available source of enzyme to help in the search for new anti-inflammatory agents that target the final processing stage of TNF-alpha production...
  22. ncbi L-DOPA-induced dyskinesia in the rat is associated with striatal overexpression of prodynorphin- and glutamic acid decarboxylase mRNA
    M A Cenci
    Wallenberg Neuroscience Center, Institute of Physiology and Neuroscience, University of Lund, 223 62 Lund, Sweden
    Eur J Neurosci 10:2694-706. 1998
    ..Due to its treatment-dependent expression, and strong correlation with the associated dyskinetic symptoms, striatal PDyn mRNA, in particular, may play a role in the mechanisms of behavioural sensitization brought about by the drug...
  23. ncbi Procalcitonin assay in systemic inflammation, infection, and sepsis: clinical utility and limitations
    Kenneth L Becker
    Veterans Affairs Medical Center, Washington, DC, USA
    Crit Care Med 36:941-52. 2008
    ..In particular, the need for a more sensitive assay will be emphasized. For these purposes, the medical literature comprising clinical studies pertaining to the measurement of serum ProCT in various clinical settings was examined...
  24. ncbi Predictive value of procalcitonin and interleukin 6 in critically ill patients with suspected sepsis
    Ville Pettila
    Department of Surgery, Division of Anesthesiology and Intensive Care Medicine, Helsinki University Hospital, P O Box 340, 00029 HUS, Helsinki, Finland
    Intensive Care Med 28:1220-5. 2002
    ....
  25. pmc Procalcitonin in sepsis and systemic inflammation: a harmful biomarker and a therapeutic target
    Kenneth L Becker
    George Washington University and Veterans Affairs Medical Center, Washington, DC 20422, USA
    Br J Pharmacol 159:253-64. 2010
    ..An experimental groundwork has been established that suggests a potential applicability of such therapy in septic humans...
  26. pmc Overlapping functions of components of a bacterial Sec-independent protein export pathway
    F Sargent
    Nitrogen Fixation Laboratory, John Innes Centre, Colney, Norwich NR4 7UH
    EMBO J 17:3640-50. 1998
    ..A mutation previously assigned to the hcf106 homologue encoded at the tatABCD locus, mttA, lies instead in the tatB gene...
  27. ncbi Procalcitonin-guided interventions against infections to increase early appropriate antibiotics and improve survival in the intensive care unit: a randomized trial
    Jens U Jensen
    Copenhagen HIV Programme, University of Copenhagen, Copenhagen, Denmark
    Crit Care Med 39:2048-58. 2011
    ..The objective of this trial was to determine whether a strategy of antimicrobial spectrum escalation, guided by daily measurements of the biomarker procalcitonin, could reduce the time to appropriate therapy, thus improving survival...
  28. ncbi Activation of p75NTR by proBDNF facilitates hippocampal long-term depression
    Newton H Woo
    Section on Neural Development and Plasticity, LCSN, NICHD, Porter Neuroscience Research Center, 35 Lincoln Drive, Bethesda, Maryland 20892 3714, USA
    Nat Neurosci 8:1069-77. 2005
    ....
  29. ncbi Defective prelamin A processing and muscular and adipocyte alterations in Zmpste24 metalloproteinase-deficient mice
    Alberto M Pendas
    Departamento de Bioquimica y Biologia Molecular, Facultad de Medicina, Instituto Universitario de Oncologia, Universidad de Oviedo, 33006 Oviedo, Spain
    Nat Genet 31:94-9. 2002
    ..These results indicate that prelamin A is a specific substrate for Zmpste24 and demonstrate the usefulness of genetic approaches for identifying the in vivo substrates of proteolytic enzymes...
  30. ncbi High prevalence and mapping of pre-S deletion in hepatitis B virus carriers with progressive liver diseases
    Bing Fang Chen
    School of Medicine, Fu Jen Catholic University, Taipei, Taiwan
    Gastroenterology 130:1153-68. 2006
    ..The interactions among pre-S deletion, precore (PC) mutation, and basal core promoter (BCP) mutation in various stages of chronic hepatitis B virus (HBV) infection remain unclear and were thus investigated in this study...
  31. ncbi C-reactive protein and procalcitonin as predictors of survival and septic shock in ventilator-associated pneumonia
    G Hillas
    Dept of Respiratory and Critical Care Medicine, SOTIRIA Chest Diseases Hospital, Athens, Greece
    Eur Respir J 35:805-11. 2010
    ..The only factor predicting the development of septic shock was SOFA on D1 (OR 7.44, 95% CI 1.330-5.715). Neither PCT and CRP threshold values nor their kinetics can predict VAP survival or septic shock development...
  32. pmc Expanding the repertoire of amyloid polymorphs by co-polymerization of related protein precursors
    Claire J Sarell
    Astbury Centre for Structural Molecular Biology and School of Molecular and Cellular Biology, University of Leeds, Leeds LS2 9JT, United Kingdom
    J Biol Chem 288:7327-37. 2013
    ....
  33. ncbi Pre-S mutant surface antigens in chronic hepatitis B virus infection induce oxidative stress and DNA damage
    Yi Hsuan Hsieh
    Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan 70101, Taiwan
    Carcinogenesis 25:2023-32. 2004
    ..These results indicate that pre-S1/S2 mutant HBsAg, which make up GGHs, induce oxidative DNA damage and mutations in hepatocytes in the late stages of HBV infection...
  34. pmc Circulating preproinsulin signal peptide-specific CD8 T cells restricted by the susceptibility molecule HLA-A24 are expanded at onset of type 1 diabetes and kill β-cells
    Deborah Kronenberg
    National Institute for Health Research Comprehensive Biomedical Research Centre at Guy s and St Thomas National Health Service Foundation Trust and King s College London, London, UK
    Diabetes 61:1752-9. 2012
    ..PPI-specific, HLA-A24-restricted CD8 T cells are expanded in patients with recent-onset disease. Human islet cells process and present PPI(3-11), rendering themselves targets for CTL-mediated killing...
  35. ncbi Biomarkers in respiratory tract infections: diagnostic guides to antibiotic prescription, prognostic markers and mediators
    M Christ-Crain
    Department of Internal Medicine, University Hospital Basel, Petersgraben 4, CH 4031 Basel, Switzerland
    Eur Respir J 30:556-73. 2007
    ..In several animal models the modulation and neutralisation of hormokines during infection was shown to improve survival, and thus might open new treatment options for severe infections, especially of the respiratory tract...
  36. pmc Alpha-fetoprotein, des-gamma carboxyprothrombin, and lectin-bound alpha-fetoprotein in early hepatocellular carcinoma
    Jorge A Marrero
    University of Michigan, Ann Arbor, Michigan 48109, USA
    Gastroenterology 137:110-8. 2009
    ..The aims of this study were to determine performance of DCP and AFP-L3% for the diagnosis of early HCC; whether they complement AFP; and what factors affect DCP, AFP-L3%, or AFP levels...
  37. ncbi Targeted deletion of the tachykinin 4 gene (TAC4-/-) influences the early stages of B lymphocyte development
    Alexandra Berger
    Division of Stem Cell and Developmental Biology, Ontario Cancer Institute, Princess Margaret Hospital, Toronto, ON, Canada
    Blood 116:3792-801. 2010
    ....
  38. ncbi Procalcitonin behaves as a fast responding acute phase protein in vivo and in vitro
    M W Nijsten
    Department of Surgery, University Hospital Groningen, and the Groningen Institute for Drug Studies, The Netherlands
    Crit Care Med 28:458-61. 2000
    ..The source of production and its mechanism of induction are unknown. We investigated the inducibility of PCT both in vivo and in vitro and compared the behavior of PCT with those of SAA and CRP...
  39. ncbi The role of procalcitonin in febrile neutropenic patients: review of the literature
    Y Sakr
    Department of Anaesthesiology and Intensive Care, Friedrich Schiller University, Erlanger Allee 103, Jena, Germany
    Infection 36:396-407. 2008
    ....
  40. ncbi Utility of procalcitonin concentration in the evaluation of patients with malignant diseases and elevated C-reactive protein plasma concentrations
    Silke Schuttrumpf
    Department of Hematology Oncology, University of Gottingen, Gottingen, Germany
    Clin Infect Dis 43:468-73. 2006
    ..Elevated plasma concentrations of the C-reactive protein (CRP) are frequently found in patients with malignant diseases. Discrimination between infection and noninfectious acute-phase reactions is essential for therapeutic decisions...
  41. pmc Envoplakin, a novel precursor of the cornified envelope that has homology to desmoplakin
    C Ruhrberg
    Keratinocyte Laboratory, Imperial Cancer Research Fund, London, United Kingdom
    J Cell Biol 134:715-29. 1996
    ..These data suggest that the 210-kD protein may link the cornified envelope to desmosomes and keratin filaments. We propose that the 210-kD protein be named "envoplakin."..
  42. ncbi Serum levels of C-reactive protein and procalcitonin in critically ill patients with cirrhosis of the liver
    Daliana Peres Bota
    Department of Intensive Care, Erasme Hospital, Free University of Brussels, Brussels, Belgium
    J Lab Clin Med 146:347-51. 2005
    ..Moreover, the predictive power of CRP and PCT for infection was similar for patients with and without cirrhosis...
  43. ncbi Mono- and dibasic proteolytic cleavage sites in insect neuroendocrine peptide precursors
    J A Veenstra
    Laboratoire de Neuroendocrinologie, Universite Bordeaux I, Talence, France
    Arch Insect Biochem Physiol 43:49-63. 2000
    ..Arch. Insect Biochem. Physiol. 43:49-63, 2000...
  44. ncbi The plasma elimination rate and urinary secretion of procalcitonin in patients with normal and impaired renal function
    M Meisner
    Department of Anaesthesiology and Intensive Care Therapy, University of Jena, Bachstr. 18, D-07743 Jena, Germany
    Eur J Anaesthesiol 18:79-87. 2001
    ..We conclude that procalcitonin can be used diagnostically in patients with renal failure as well as in those with normal renal function...
  45. ncbi Pre-S deletion and complex mutations of hepatitis B virus related to advanced liver disease in HBeAg-negative patients
    Chien Hung Chen
    Division of Hepatogastroenterology, Department of Internal Medicine, Chang Gung Memorial Hospital Kaohsiung Medical Center, Kaohsiung, Taiwan
    Gastroenterology 133:1466-74. 2007
    ....
  46. ncbi Procalcitonin for guidance of antibiotic therapy
    Philipp Schuetz
    Harvard School of Public Health, MA, USA
    Expert Rev Anti Infect Ther 8:575-87. 2010
    ..This review aims to provide physicians with an overview of the strengths and limitations of procalcitonin guidance for antibiotic therapy when used in different clinical settings and in patients with different underlying infections...
  47. ncbi Alterations of nuclear envelope and chromatin organization in mandibuloacral dysplasia, a rare form of laminopathy
    Ilaria Filesi
    Laboratory of Clinical Biochemistry and Department of Neuroscience, University of Roma Tor Vergata, Rome, Italy
    Physiol Genomics 23:150-8. 2005
    ..These results strongly suggest that altered chromatin remodeling is a key event in the cascade of epigenetic events causing MADA and could be related to the premature-aging phenotype...
  48. ncbi The nerve growth factor precursor proNGF exhibits neurotrophic activity but is less active than mature nerve growth factor
    Margaret Fahnestock
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario, Canada
    J Neurochem 89:581-92. 2004
    ..These data, coupled with our previous report that proNGF is the major form of NGF in the CNS, suggest that proNGF could be responsible for much of the biological activity normally attributed to mature NGF in vivo...
  49. pmc Structural determinants of cadherin-23 function in hearing and deafness
    Marcos Sotomayor
    Howard Hughes Medical Institute, Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA
    Neuron 66:85-100. 2010
    ..The structures define an uncharacterized cadherin family and, with simulations, suggest mechanisms underlying inherited deafness and how cadherin-23 may bind with itself and with protocadherin-15 to form the tip link...
  50. ncbi Mutations of keratinocyte transglutaminase in lamellar ichthyosis
    M Huber
    Department of Dermatology, Centre Hospitalier Universitaire Vandois CHUV, Hôpital de Beaumont, Lausanne, Switzerland
    Science 267:525-8. 1995
    ..These data suggest that defects in TGK cause lamellar ichthyosis and that intact cross-linkage of cornified cell envelopes is required for epidermal tissue homeostasis...
  51. ncbi Distinctive roles of PHAP proteins and prothymosin-alpha in a death regulatory pathway
    Xuejun Jiang
    Howard Hughes Medical Institute, Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Science 299:223-6. 2003
    ..Thus, this chemical-biological combinatory approach has revealed the regulatory roles of oncoprotein ProT and tumor suppressor PHAP in apoptosis...
  52. pmc Viral and cellular determinants involved in hepadnaviral entry
    Dieter Glebe
    Institute of Medical Virology, Justus Liebig University of Giessen, Frankfurter Strasse 107, D 35392 Giessen, Germany
    World J Gastroenterol 13:22-38. 2007
    ..g. test the fitness of escape mutants), (3) titrate and map neutralizing antibodies, (4) improve current vaccines to combat acute and chronic infections of hepatitis B, and (5) develop entry inhibitors for future clinical applications...
  53. ncbi Cholinergic involvement in Alzheimer's disease. A link with NGF maturation and degradation
    A Claudio Cuello
    Department of Pharmacology and Therapeutics, McGill University, Montreal, QC, H3G 1Y6, Canada
    J Mol Neurosci 40:230-5. 2010
    ....
  54. pmc Procalcitonin for diagnosis of infection and guide to antibiotic decisions: past, present and future
    Philipp Schuetz
    Harvard School of Public Health, 667 Huntington Ave, 02115 Boston MA, USA
    BMC Med 9:107. 2011
    ..The aim of this review is to summarize the current evidence for PCT in different infections and clinical settings, and discuss the reliability of this marker when used with validated diagnostic algorithms...
  55. ncbi Effect of procalcitonin-guided treatment in patients with infections: a systematic review and meta-analysis
    H Tang
    Intensive Care Unit, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Zhejiang, People s Republic of China
    Infection 37:497-507. 2009
    ....
  56. ncbi Procalcitonin-guided algorithms of antibiotic therapy in the intensive care unit: a systematic review and meta-analysis of randomized controlled trials
    Petros Kopterides
    Second Critical Care Department, Attiko University Hospital, University of Athens Medical School, Athens, Greece
    Crit Care Med 38:2229-41. 2010
    ..We sought to determine the effectiveness and safety of procalcitonin-guided algorithms in the management of septic patients in the intensive care unit...
  57. pmc Progerin and telomere dysfunction collaborate to trigger cellular senescence in normal human fibroblasts
    Kan Cao
    Genome Technology Branch, National Human Genome Research Institute, NIH, Bethesda, Maryland 20892 0148, USA
    J Clin Invest 121:2833-44. 2011
    ....
  58. ncbi Procalcitonin algorithms for antibiotic therapy decisions: a systematic review of randomized controlled trials and recommendations for clinical algorithms
    Philipp Schuetz
    Department of Emergency Medicine, Harvard School of Public Health, Boston, MA 02115, USA
    Arch Intern Med 171:1322-31. 2011
    ..We propose specific procalcitonin algorithms for low-, moderate-, and high-acuity patients as a basis for future trials aiming at reducing antibiotic overconsumption...
  59. ncbi Dissection of the mitochondrial import and assembly pathway for human Tom40
    Adam D Humphries
    Department of Biochemistry, La Trobe University, Melbourne 3086, Australia
    J Biol Chem 280:11535-43. 2005
    ..Nevertheless, we show that Tom40 assembly is reduced in mitochondria depleted of human Sam50. These findings are discussed in context with current models from fungal studies...
  60. pmc Procalcitonin and C-reactive protein during systemic inflammatory response syndrome, sepsis and organ dysfunction
    Gian Paolo Castelli
    Intensive Care, Anesthesiology and Pain Relief Unit, C Poma Hospital, Mantova, Italy
    Crit Care 8:R234-42. 2004
    ..We hypothesised that PCT and CRP concentrations are different in patients with infection or with no infection at a similar severity of organ dysfunction or of systemic inflammatory response...
  61. pmc Mutations of the protocadherin gene PCDH15 cause Usher syndrome type 1F
    Z M Ahmed
    Laboratory of Molecular Genetics, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, 5 Research Court, Rockville, MD, USA
    Am J Hum Genet 69:25-34. 2001
    ..A Northern blot probed with the PCDH15 cytoplasmic domain showed expression in the retina, consistent with its pathogenetic role in the retinitis pigmentosa associated with USH1F...
  62. pmc Diagnostic and prognostic accuracy of clinical and laboratory parameters in community-acquired pneumonia
    Beat Muller
    Departments of Internal Medicine, University Hospital, Petersgraben 4, CH 4031, Basel, Switzerland
    BMC Infect Dis 7:10. 2007
    ..This study aims to evaluate the diagnostic and prognostic accuracy of clinical signs and symptoms and laboratory biomarkers for CAP...
  63. ncbi Human lipodystrophies linked to mutations in A-type lamins and to HIV protease inhibitor therapy are both associated with prelamin A accumulation, oxidative stress and premature cellular senescence
    M Caron
    INSERM U680, Universite Pierre et Marie Curie Paris 6, Faculte de Medecine, site Saint Antoine, 27 rue Chaligny, 75571 Paris Cedex 12, France
    Cell Death Differ 14:1759-67. 2007
    ..These alterations could participate in the pathophysiology of lipodystrophic syndromes and lead to premature ageing complications...
  64. pmc Multiple functions of precursor BDNF to CNS neurons: negative regulation of neurite growth, spine formation and cell survival
    Hisatsugu Koshimizu
    National Institute of Advanced Industrial Science and Technology AIST, Ikeda, 563 8577 Japan
    Mol Brain 2:27. 2009
    ....
  65. ncbi Procalcitonin for reduced antibiotic exposure in ventilator-associated pneumonia: a randomised study
    D Stolz
    Clinic of Pulmonary Medicine and Respiratory Cell Research, University Hospital, Petersgraben 4, CH 4031 Basel, Switzerland
    Eur Respir J 34:1364-75. 2009
    ..Serum procalcitonin reduces antibiotic therapy exposure in patients with ventilator associated pneumonia...
  66. ncbi Plasma procalcitonin and the risk of cardiovascular events and death: a prospective population-based study
    A Schiopu
    Department of Clinical Sciences, Lund University, Skåne University Hospital Malmö, Malmo, Sweden
    J Intern Med 272:484-91. 2012
    ..We evaluated the ability of PCT to predict future cardiovascular events in a population of apparently healthy individuals...
  67. pmc Different types of ground glass hepatocytes in chronic hepatitis B virus infection contain specific pre-S mutants that may induce endoplasmic reticulum stress
    Hui Ching Wang
    Graduate Institutes of Basic Medical Sciences, Molecular Medicine, and Immunology and Microbiology, National Cheng Kung University College of Medicine, Tainan, Taiwan
    Am J Pathol 163:2441-9. 2003
    ..This study therefore demonstrates that different GGHs may contain specific mutants and exhibit differential biological activities...
  68. ncbi Cadherin 23 and protocadherin 15 interact to form tip-link filaments in sensory hair cells
    Piotr Kazmierczak
    The Scripps Research, Institute Department of Cell Biology, La Jolla, California 92037, USA
    Nature 449:87-91. 2007
    ..Our studies define the molecular composition of tip links and provide a conceptual base for exploring the mechanisms of sensory impairment associated with mutations in CDH23 and PCDH15...
  69. pmc Pro-NGF, sortilin, and p75NTR: potential mediators of injury-induced apoptosis in the mouse dorsal root ganglion
    Melinda G Arnett
    Department of Anatomy and Cell Biology, University of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City, KS 66160, USA
    Brain Res 1183:32-42. 2007
    ..These results propose pro-NGF-induced, p75NTR-sortilin-mediated neuronal death as a critical aspect of nerve injury-induced death in the DRG...
  70. pmc Biological activity of nerve growth factor precursor is dependent upon relative levels of its receptors
    Raheleh Masoudi
    Department of Biology, McMaster University, Hamilton, Ontario L8N 3Z5, Canada
    J Biol Chem 284:18424-33. 2009
    ..We conclude that the relative level of proNGF receptors determines whether this precursor exhibits neurotrophic or apoptotic activity...
  71. ncbi Thyroid-stimulating hormone, a novel, locally produced modulator of human epidermal functions, is regulated by thyrotropin-releasing hormone and thyroid hormones
    Eniko Bodo
    Department of Dermatology, University of Lubeck, Ratzeburger Allee 160, D 23538 Lubeck, Germany
    Endocrinology 151:1633-42. 2010
    ..Intraepidermal TSH expression appears to be regulated by the classical endocrine controls that determine the systemic HPT axis...
  72. ncbi Distinct expression of Cbln family mRNAs in developing and adult mouse brains
    Eriko Miura
    Department of Anatomy, Hokkaido University School of Medicine, Sapporo 060 8638, Japan
    Eur J Neurosci 24:750-60. 2006
    ..These results will provide a molecular-anatomical basis for future studies that characterize roles played by the Cbln family...
  73. pmc Pro-nerve growth factor induces autocrine stimulation of breast cancer cell invasion through tropomyosin-related kinase A (TrkA) and sortilin protein
    Yohann Demont
    INSERM U908 Growth Factor Signaling in Breast Cancer, University of Lille, Villeneuve d Ascq 59655, France
    J Biol Chem 287:1923-31. 2012
    ..These data reveal the existence of an autocrine loop stimulated by proNGF and mediated by TrkA and sortilin, with the activation of Akt and Src, for the stimulation of breast cancer cell invasion...
  74. ncbi In vitro and in vivo calcitonin I gene expression in parenchymal cells: a novel product of human adipose tissue
    Philippe Linscheid
    Department of Research, University Hospitals, Hebelstrasse 20, 4031 Basel, Switzerland
    Endocrinology 144:5578-84. 2003
    ..The inhibiting effect of IFNgamma on IL-1beta-induced CT mRNA expression and on ProCT secretion might explain previous observations that serum ProCT concentrations increase less in systemic viral compared with bacterial infections...
  75. pmc Regulation of PCDH15 function in mechanosensory hair cells by alternative splicing of the cytoplasmic domain
    Stuart W Webb
    Dorris Neuroscience Center and Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Development 138:1607-17. 2011
    ..Our findings reveal an essential role for PCDH15-CD2 in the formation of kinociliary links and hair bundle polarization, and show that several PCDH15 isoforms can function redundantly at tip links...
  76. ncbi Comparison of procalcitonin and C-reactive protein as markers of sepsis
    Aldo Luzzani
    Institute of Anesthesiology and Intensive Care, University Hospital, Verona, Italy
    Crit Care Med 31:1737-41. 2003
    ..To compare the clinical informative value of procalcitonin (PCT) and C-reactive protein (CRP) plasma concentrations in the detection of infection and sepsis and in the assessment of severity of sepsis...
  77. pmc Regulation of apoptosis by the p8/prothymosin alpha complex
    Cedric Malicet
    Institut National de la Santé et de la Recherche Médicale Unité 624, Stress Cellulaire, 163 Avenue de Luminy, Case 915, Parc Scientifique et Technologique de Luminy, 13288 Marseille Cedex 9, France
    Proc Natl Acad Sci U S A 103:2671-6. 2006
    ..These results strongly suggest that the antiapoptotic response of HeLa cells upon staurosporine treatment requires expression of both p8 and ProTalpha...
  78. pmc Functional cross-talk between beta-catenin and NFkappaB signaling pathways in colonic crypts of mice in response to progastrin
    Shahid Umar
    Department of Internal Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
    J Biol Chem 284:22274-84. 2009
    ..Our studies suggest a novel possibility that activation of beta-catenin, downstream to the IKKalpha,beta/NFkappaB pathway, may be integral to the hyperproliferative effects of progastrin on proximal colonic crypts...
  79. ncbi Early decrease in α-fetoprotein, but not des-γ-carboxy prothrombin, predicts sorafenib efficacy in patients with advanced hepatocellular carcinoma
    Teiji Kuzuya
    Division of Gastroenterology and Hepatology, Musashino Red Cross Hospital, Musashino, Tokyo, Japan
    Oncology 81:251-8. 2011
    ....
  80. ncbi Latent transforming growth factor-beta 1 and its binding protein are components of extracellular matrix microfibrils
    J Taipale
    Departments of Virology, University of Helsinki, Finland
    J Histochem Cytochem 44:875-89. 1996
    ..The present results indicate that latent TGF-beta 1 complexes are components of the extracellular matrix and suggest that alterations of the pericellular matrix could result in aberrant TGF-beta signaling...
  81. pmc ProNGF mediates death of Natural Killer cells through activation of the p75NTR-sortilin complex
    Mary Louise Rogers
    Department of Human Physiology, School of Medicine, Flinders University, GPO Box 2100 Adelaide 5001, Australia
    J Neuroimmunol 226:93-103. 2010
    ..This was reduced by blocking sortilin with neurotensin. We conclude that proNGF induced apoptosis of NK cells may have important implications for limiting the innate immune response...
  82. ncbi Significance of alpha-fetoprotein and des-gamma-carboxy prothrombin in patients with hepatocellular carcinoma undergoing hepatectomy
    Kentaroh Yamamoto
    Department of Surgery, Hepato Biliary Pancreatic Surgery Division, Artificial Organ and Transplantation Division, University of Tokyo, Tokyo, Japan
    Ann Surg Oncol 16:2795-804. 2009
    ....
  83. ncbi Procalcitonin as an early marker of infection in neonates and children
    A M C van Rossum
    Medical Centre Rijnmond Zuid, Rotterdam, Netherlands
    Lancet Infect Dis 4:620-30. 2004
    ..Procalcitonin is therefore a useful additional tool for the diagnosis of bacterial disease in neonates and children...
  84. ncbi Optimised patient transfer using an innovative multidisciplinary assessment in Kanton Aargau (OPTIMA I): an observational survey in lower respiratory tract infections
    W C Albrich
    Medical University Department of the University of Basel, Kantonsspital Aarau, Tellstrasse, CH
    Swiss Med Wkly 141:w13237. 2011
    ..We describe our current triage practice and assess the potential of a combination of CURB65 with proadrenomedullin (ProADM) levels for triage decisions...
  85. pmc Use of plasma C-reactive protein, procalcitonin, neutrophils, macrophage migration inhibitory factor, soluble urokinase-type plasminogen activator receptor, and soluble triggering receptor expressed on myeloid cells-1 in combination to diagnose infections
    Kristian Kofoed
    Clinical Research Unit, Copenhagen University Hospital, Hvidovre, Kettegaard Alle 30, DK 2650 Hvidovre, Denmark
    Crit Care 11:R38. 2007
    ..Combinations of markers, as opposed to single ones, may improve diagnosis and thereby survival. We therefore compared the diagnostic characteristics of novel and routinely used biomarkers of sepsis alone and in combination...
  86. ncbi Involvement of prelamin A in laminopathies
    N M Maraldi
    Laboratory of Cell Biology, Istituto Ortopedico Rizzoli, Bologna, Italy
    Crit Rev Eukaryot Gene Expr 17:317-34. 2007
    ....
  87. ncbi NG peptides: a novel family of neurophysin-associated neuropeptides
    Maurice R Elphick
    Queen Mary University of London, School of Biological and Chemical Sciences, Mile End Road, London, E1 4NS, UK
    Gene 458:20-6. 2010
    ....
  88. pmc Uptake and recycling of pro-BDNF for transmitter-induced secretion by cortical astrocytes
    Matteo Bergami
    Department of Human and General Physiology, University of Bologna, I 40126 Bologna, Italy
    J Cell Biol 183:213-21. 2008
    ..Thus, astrocytes contain an endocytic compartment competent for pro-BDNF recycling, suggesting a specialized form of bidirectional communication between neurons and glia...
  89. ncbi Serum procalcitonin and other biologic markers to distinguish between bacterial and aseptic meningitis
    Francois Dubos
    Clinical Epidemiology Unit, Department of Pediatrics, Saint Vincent de Paul Hospital, AP HP, Paris Descartes University, and INSERM U149, Paris, France
    J Pediatr 149:72-6. 2006
    ..To identify the biologic tests that best distinguish between bacterial and aseptic meningitis in an emergency department (ED)...
  90. pmc Plastid proteome assembly without Toc159: photosynthetic protein import and accumulation of N-acetylated plastid precursor proteins
    Sylvain Bischof
    Department of Biology, Eidgenossische Technische Hochschule Zurich, 8092 Zurich, Switzerland
    Plant Cell 23:3911-28. 2011
    ....
  91. pmc Procalcitonin and C-reactive protein in hospitalized adult patients with community-acquired pneumonia or exacerbation of asthma or COPD
    Mona Bafadhel
    Institute for Lung Health, University of Leicester, Leicester, England
    Chest 139:1410-8. 2011
    ..We aimed to compare the usefulness of the biomarkers procalcitonin and C-reactive protein (CRP) in patients with pneumonia or exacerbations of asthma or COPD...
  92. ncbi Cutting edge: cyclic polypeptide and aminoglycoside antibiotics trigger IL-1β secretion by activating the NLRP3 inflammasome
    Ramanjaneyulu Allam
    Medizinische Poliklinik, Universitat Munchen, Munich, Germany
    J Immunol 186:2714-8. 2011
    ..All four antibiotics induced neutrophil influx into the peritoneal cavity of mice, which required NLRP3 only in the case of polymyxin B. Together, certain antibiotics have the potential to directly activate innate immunity of the host...
  93. pmc Multiple precursor proteins bind individual Tat receptor complexes and are collectively transported
    Xianyue Ma
    Horticultural Sciences Department and Plant Molecular and Cellular Biology, University of Florida, Gainesville, FL, USA
    EMBO J 29:1477-88. 2010
    ..These results imply a novel aspect of Tat systems, whereby multiple precursor-binding sites can act in concert to transport an interlinked oligo-precursor protein...
  94. pmc Proneurotrophin-3 may induce Sortilin-dependent death in inner ear neurons
    Jacob Tauris
    Department of Otorhinolaryngology, Aarhus University Hospital, Nørrebrogade 44, 8000 Aarhus C, Denmark
    Eur J Neurosci 33:622-31. 2011
    ..However, our results suggest that proNT3 and proBDNF may play important roles in the response to noise-induced injuries or ototoxic damage via the Sortilin:p75(NTR) death-signalling complex...
  95. pmc Double homozygous waltzer and Ames waltzer mice provide no evidence of retinal degeneration
    Zubair M Ahmed
    National Institute on Deafness and Other Communication Disorders, NIH, Rockville, MD 20850, USA
    Mol Vis 14:2227-36. 2008
    ..Does homozygosity for both v and av mutant alleles (i.e., a double homozygous mouse) cause retinal degeneration or an obvious retinal histopathology?..
  96. ncbi Serum procalcitonin at the time of admission to the ICU as a predictor of short-term mortality
    Fan Su Meng
    ICU, General Hospital of Guangzhou Military Command, 111 Liu Hua Road, Yue Xiu District, Guangzhou, China
    Clin Biochem 42:1025-31. 2009
    ..This purpose of this study was to determine if serum procalcitonin (PCT) concentration at the time of admission to the ICU is a predictor of all-cause short-term mortality...
  97. pmc Comparison of thromboelastometry with procalcitonin, interleukin 6, and C-reactive protein as diagnostic tests for severe sepsis in critically ill adults
    Michael Adamzik
    Klinik für Anästhesiologie und Intensivmedizin, Universitätsklinikum Essen und Universität Duisburg Essen, Hufelandstr, 55, 45130 Essen, Germany
    Crit Care 14:R178. 2010
    ..We investigated whether thromboelastometry variables are suitable as biomarkers for severe sepsis in critically ill adults...
  98. ncbi Early detection of an early onset infection in the neonate based on measurements of procalcitonin and C-reactive protein concentrations in cord blood
    Agnieszka Kordek
    Pomeranian Medical University, Szczecin, Poland
    Clin Chem Lab Med 46:1143-8. 2008
    ....
  99. ncbi Des-gamma-carboxyprothrombin, alpha-fetoprotein and AFP-L3 in patients with chronic hepatitis, cirrhosis and hepatocellular carcinoma
    Francisco A Durazo
    The Pfleger Liver Institute, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    J Gastroenterol Hepatol 23:1541-8. 2008
    ....
  100. ncbi Prediction about severity and outcome of sepsis by pro-atrial natriuretic peptide and pro-adrenomedullin
    Rui lan Wang
    First People s Hospital, Shanghai Jiaotong University, China
    Chin J Traumatol 13:152-7. 2010
    ....
  101. ncbi Prognostic values of alpha-fetoprotein and protein induced by vitamin K absence or antagonist-II in hepatitis B virus-related hepatocellular carcinoma: a prospective study
    Hyoung Su Kim
    Department of Internal Medicine, Kangdong Sacred Heart Hospital of Hallym University Medical Center, Seoul, Republic of Korea
    J Clin Gastroenterol 43:482-8. 2009
    ..However, prognostic values of AFP and PIVKA-II remain clarified in hepatitis B virus (HBV)-associated HCC. This study was aimed to evaluate the prognostic values of AFP and PIVKA-II in HBV-associated HCC...

Research Grants62

  1. Functional Selection of Novel Ligands from the Neuroendocrine Secretome
    David Larocca; Fiscal Year: 2010
    ..We will use a novel phage particle display strategy designed to identify active ligands from within larger protein precursors to identify novel ligands and their target cells...
  2. Molecular Mechanisms and Treatment of Primary Amyloid AL Cardiomyopathy
    Ronglih Liao; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Amyloidosis represents a group of human diseases in which protein precursors exhibit altered secondary structure and form insoluble protein aggregates in tissues...
  3. Aging and the Tissue Response to Misfolded Proteins
    Joel N Buxbaum; Fiscal Year: 2012
    ..type II diabetes and senile systemic amyloidosis are the result of tissue deposition of the wild type protein precursors A2, islet amyloid polypeptide and transthyretin, respectively...
  4. The protein nutrition of the symbiotic system between /Drosophila/and its gut mic
    ANGELA E SEARLE; Fiscal Year: 2013
    ..It will test the hypothesis that host genetic variation in the assimilation and allocation of protein precursors underlies variation in dependence on symbiotic associations for maximal health, and will use genomic ..
  5. VITAMIN K-DEPENDENT PROTEINS IN LIVER & ISOLATED CELLS
    Reidar Wallin; Fiscal Year: 1992
    ..Another part of this proposal focusses on gamma-carboxylation of protein precursors of coagulation factor II in rat and human liver...
  6. GENETIC ANALYSIS OF PICORNAVIRUS RNA REPLICATION IN VIVO
    JAMES FLANEGAN; Fiscal Year: 2006
    ..reactions, we are using genetic complementation assays to identify specific viral proteins and viral protein precursors that are required for the assembly of functional RNA replication complexes...
  7. Pilus Assembly in Gram-Positive Bacteria
    Hung Ton That; Fiscal Year: 2010
    ..organelle for the covalent attachment of proteins, a mechanism that requires sorting signals of surface protein precursors and sortase, which cleaves sorting signals at the LPXTG motif and links the C-terminus of surface proteins ..
  8. Mechanisms of divalent cation associated amyloidosis
    Catherine Eakin; Fiscal Year: 2004
    ..However, in many types of fiber formation, interaction of the protein precursors with divalent metals promotes aggregation...
  9. TRANSTHYRETIN DEPOSITION IN AGING TRANSGENIC MICE
    Joel Buxbaum; Fiscal Year: 2004
    ..The fibrils may be derived from any one of 16 currently known protein precursors of either normal or variant amino acid sequence...
  10. PROTEIN TRANSLOCATION ACROSS ORGANELLE MEMBRANES
    Arnold Strauss; Fiscal Year: 1990
    ..cDNA clones encoding all or part of these protein precursors have been isolated...
  11. MOSQUITO OOCYTES - MECHANISM OF PROTEIN ACCUMULATION
    Alexander Raikhel; Fiscal Year: 2001
    ..one of the most critical processes in the life history of the mosquito: the specific recognition of yolk protein precursors by oocyte receptors leading to their accumulation as the protein reserve necessary for successful egg and ..
  12. DELETERIOUS PRODUCTS OF PLASMA CELL DYSCRASIAS
    Allen Edmundson; Fiscal Year: 2000
    ..of amyloidogenic antibody proteins, or fragments therefrom, and to determine the general features of the protein precursors of amyloid fibrils, and identify what makes them so destructive...
  13. INSULIN SYNTHESIS, STORAGE, AND SECRETION IN VITRO
    Gerold Grodsky; Fiscal Year: 1993
    ..these lines will be used as a model for studying normal and abnormal processing and miss-sorting of protein precursors. The peptides will be chemically identified and their distribution, either into the secretory system or as ..
  14. STUDIES ON THE GENERATION OF INSULIN MEDIATORS
    Guillermo Romero; Fiscal Year: 1993
    ..is directly associated to the generation of insulin mediators and to identify at least some of the possible protein precursors. It is also proposed to investigate the specific mechanisms of cleavage using metabolic labeling techniques...
  15. REGULATION OF VITELLOGENIC GENES IN THE MOSQUITO
    Alexander Raikhel; Fiscal Year: 2000
    ..Biochemical and biosynthetic characterization of yolk protein precursors Vg and 53KP will continue.
  16. Serpin Protease Inhibitors & Opioid Neuropeptides
    Vivian Hook; Fiscal Year: 2006
    ..Serpin regulation of opioid peptides that mediate analgesia and stress may lead to development of new therapeutic approaches in pain and neurologic disease. ..
  17. Proteomics/Genomics of Opiate Analgesia and Addiction
    Vivian Hook; Fiscal Year: 2004
    ..Elucidation of distinct pathways will be significant, since it could allow future design of opiate drug regimens that provide effective analgesia, without the tolerance and dependence of addiction. ..
  18. INTEGRATED DNA SEQUENCING SYSTEM
    Vivian Hook; Fiscal Year: 2002
    ..abstract_text> ..
  19. Growth Factors, Curcumin and Colon Carcinogenesis
    Pomila Singh; Fiscal Year: 2010
    ..The results of these studies are expected to help in developing mechanism-based strategies for preventative/treatment protocols for CRCusing curcumin like agents. ..
  20. IGFS & IGF-BINDING PROTEINS IN GROWTH & DIFFERENTIATION
    Pomila Singh; Fiscal Year: 2002
    ....
  21. AUTOCRINE ROLE OF GASTRIN-LIKE PEPTIDES IN COLON CANCER
    Pomila Singh; Fiscal Year: 2002
    ..If we are successful in purifying the novel GP-R (and confirm its role in mediating the mitogenic effects of gastrins) then one can develop systemic strategies to block the receptor mediated effects in future funding periods. ..
  22. Synaptic Alterations in the Cerebral Cortex during Aging
    A Cuello; Fiscal Year: 2005
    ..abstract_text> ..
  23. BIOSYNTHESIS OF ENKEPHALIN OPIOID PEPTIDES
    Vivian Hook; Fiscal Year: 2009
    ..These findings will enhance our knowledge of the complexity of the endogenous opioid system. ..
  24. POMC Processing and Beta-Endorphine-Related Opioid Peptides
    Vivian Y H Hook; Fiscal Year: 2010
    ..New findings from this project will enhance our knowledge of the complexity of biosynthetic mechanisms for endogenous opioid and neuropeptide systems. ..
  25. NHLBI Bay Area Functional Genomics Consortium
    Stephen Young; Fiscal Year: 2007
    ..A fourth objective is to generate a limited number of genetically modified mice, for the purpose of defining the relevance of specific genes to cardiopulmonary development and disease (Components 4-6). ..
  26. Postisoprenylation Processing and the Nuclear Lamina
    Stephen Young; Fiscal Year: 2007
    ..The third aim is to understand the posttranslational processing of lamin B1 and to define the consequences of lamin B1 deficiency in mammals. ..
  27. Vcsa1 (hSMR3A) as a Marker for Diabetes
    Kelvin Davies; Fiscal Year: 2008
    ..The final aim will be to determine expression levels of hSMR3A protein from diabetic and non-diabetic patients (in saliva, blood and corporal samples) as an indicator of vascular health. [unreadable] [unreadable] [unreadable]..
  28. The Role of Vsca1 in Erectile Function
    Kelvin P Davies; Fiscal Year: 2010
    ..Vcsal/hSMR3A expression might also be used as a non-subjective marker of erectile function. ..
  29. Regulation of Slo Splicing in the Urogenital Systme
    Kelvin Davies; Fiscal Year: 2006
    ..This research project will allow Dr. Davies to develop a thorough understanding of urogenital physiology, while at the same time allowing him to utilize his experience in molecular biology. ..
  30. Hutchinson Gilford Progeria Syndrome and Atherosclerosis
    Stephen Young; Fiscal Year: 2009
    ..The PI's laboratory has extensive experience in analyzing atherogenesis in mice and is thrilled with the prospect of exploring mechanisms of atherosclerosis in HGPS. ..
  31. A Beta Vaccination: Mechanisms and Therapautic Impact
    Lennart Mucke; Fiscal Year: 2005
    ..Lastly, the proposed project will shed light on the roles of microglia in the pathogenesis of AD-related neuronal deficits. These goals and perspectives are congruent with those of RFA AG-01-003. ..
  32. Regulation of DMP1 Gene Expression in Bone and Tooth
    Shuo Chen; Fiscal Year: 2004
    ..These studies will therefore make an important contribution toward an overall understanding of the molecular basis of bone/tooth specific gene expression. ..
  33. THE NHLBI BAY AREA FUNCTIONAL GENOMICS COMSORTIUM
    Stephen Young; Fiscal Year: 2003
    ..The Consortium's resources will be distributed freely to any interested investigator and should provide a catalyst for many different NHLBI-funded research programs. ..
  34. CAAX Protein Processing and Cancer Therapy
    Stephen Young; Fiscal Year: 2007
    ..These studies should define the therapeutic potential of blocking the three different steps of CAAX protein processing. ..
  35. METABOLISM OF SPONTANEOUSLY DAMAGED PROTEINS IN AGING
    Stephen Young; Fiscal Year: 2002
    ..Finally, we propose to ask whether the expression of the repair methyltransferase in the extracellular compartment would limit the accumulation of spontaneous damage to extracellular proteins. ..
  36. Nutriuretic Peptides, the Renin-Angiotensin System, and Metabolic Risk in Obesity
    Thomas J Wang; Fiscal Year: 2010
    ..Assessment ofbiochemial markers of these pathways may identify obese individuals at higher risk of developing cardiovascular risk factors and may suggest novel therapeutic targets. ..
  37. Hypocretin and Drug Addiction
    Luis de Lecea; Fiscal Year: 2010
    ..This demonstration may lead to future treatments to prevent relapse. ..
  38. Regulation of mRNA Partitioning to the Endoplasmic Reticulum
    Christopher V Nicchitta; Fiscal Year: 2010
    ..By understanding these mechanisms, we hope to identify new targets for therapeutic intervention. ..
  39. Substance P in pathogenesis of cryptosporidiosis in AIDS
    Prema Robinson; Fiscal Year: 2004
    ..abstract_text> ..
  40. Physiological Functions of Neuropeptide S
    Rainer Reinscheid; Fiscal Year: 2009
    ..We will study the pharmacology of the mutant receptor isoforms which may help to understand the physiological consequences of the mutation in human airway tissue. ..
  41. Role of CRH in skin physiology and pathology
    Andrzej Slominski; Fiscal Year: 2004
    ..g., melanocytes and keratinocytes, and test the role of CRH/CRH-R1 axis in the regulation of human hair growth. ..
  42. Complications of Cirrhosis in American Patients
    Jorge Marrero; Fiscal Year: 2008
    ..I will supervise the conduct of the proposed research and meet with my mentors and advisors regularly. Completing this proposal will allow me to achieve my career goal and to contribute to an improve outcome of patients with HCC. ..
  43. Mechanism of Chaperone-Mediated Tumor Rejection
    Christopher Nicchitta; Fiscal Year: 2008
    ..abstract_text> ..
  44. Anatomy and Activation of Nucleus Accumbens CART Neurons
    GEORGE HUBERT; Fiscal Year: 2008
    ..This will add to our understanding of the anatomy of drug abuse and to hypothesize treatments to alleviate this major social problem. ..
  45. Regulation of Mandibular Condylar Cartialage Growth
    Robert Hinton; Fiscal Year: 2006
    ..If the perichondrial cells in MCC share regulatory features with cells in SUT rather than in SOS, this assumption is not only erroneous but may lead to inappropriate treatment strategies. ..
  46. The Molecular Mechanism of GRP94 Function
    Christopher Nicchitta; Fiscal Year: 2005
    ..abstract_text> ..
  47. Proprotein Processing, Trafficking and Secretion Gordon Conference
    Nabil Seidah; Fiscal Year: 2006
    ..The integration of protease systems that are required both for normal physiology and human disease will be relevant to our understanding of the molecular bases of diabetes, cancer, Alzheimer's and drug addiction. ..
  48. Dopamine Systems and Neuropsychiatric Changes in HIV/AIDS
    Benjamin B Gelman; Fiscal Year: 2010
    ..The project breaks ground neuroscientifically, as no autopsy study has advanced to a "task specific" behavioral correlation with circuit level anomalies of a specific neurotransmitter system. ..
  49. Role of Inter-alpha Inhibitors in Anthrax Intoxication
    Steven Opal; Fiscal Year: 2007
    ..Our research is focused on the development of a new and safe treatment based on the ability of inter-alpha proteins to prevent the fatal consequences of anthrax infection. [unreadable] [unreadable] [unreadable] [unreadable]..
  50. ROLE OF MYOSTATIN IN CACHEXIA
    Se Jin Lee; Fiscal Year: 2005
    ..abstract_text> ..
  51. Individual Differences in Anxiety: Neuropeptide-Y
    STEFANY PRIMEAUX; Fiscal Year: 2004
    ..Increased amygdalar NPY gene expression is expected to potentiate the anxiolytic and sedative effects of ethanol. Decreased amygdalar NPY gene expression is expected to attenuate the anxiolytic and sedative effects of ethanol. ..
  52. Natriuretic Peptides, Genes, and Diastolic Heart Failure
    Thomas Wang; Fiscal Year: 2007
    ..Each of these skills will be critical to the candidate's long-term goal of becoming an independent clinical investigator with a focus on heart failure. ..
  53. Recombinant Herpes Injection into Trigeminal Ganglia
    David Yeomans; Fiscal Year: 2004
    ..In so doing, we hope to provide initial support for what may be a new long-lasting treatment for trigeminal nerve-related pain. ..
  54. The Role of Filamin in Periventricular Heterotopias
    Volney Sheen; Fiscal Year: 2005
    ....
  55. NANOLITER VOLUME NUCLEAR MAGNETIC RESONANCE
    Jonathan Sweedler; Fiscal Year: 2002
    ..abstract_text> ..
  56. Novel Genes Involved in Drug Response
    Ruthann Nichols; Fiscal Year: 2002
    ..Ultimately, our research will determine the role of these gene products in mediating the effect of nicotine in humans. ..
  57. INTEGRATIVE RESPONSES TO AMINO ACID DEFICIENCY
    Dorothy Gietzen; Fiscal Year: 2004
    ....
  58. Natural ligands for 2 endothelin-like orphan receptors
    Rainer Reinscheid; Fiscal Year: 2004
    ..Identification of the natural ligands will enable us to study the physiological functions of these two orphan GPCRs under normal and pathological conditions. ..
  59. The hypocretins and alcohol dependence
    Luis de Lecea; Fiscal Year: 2003
    ..The development of these mouse models will generate invaluable tools to assess the role of the hypocretins on drug abuse, and may help to design better treatments for sleep disorders associated with alcoholism. ..
  60. PHYSIOLOGY OF THE PROLACTIN RELEASING PEPTIDES
    Willis K Samson; Fiscal Year: 2010
    ..Additionally, these studies will provide further insight into the coordinated hormonal and autonomic responses to stress. ..
  61. LTQ Orbitrap tandem mass spectrometer
    Catherine Fenselau; Fiscal Year: 2007
    ..This commercially available, technologically sophisticated instrument will support meritorious projects on a shared use, highly cost-effective basis, and foster multidisciplinary interaction. [unreadable] [unreadable] [unreadable]..