pregnancy proteins

Summary

Summary: Proteins produced by organs of the mother or the PLACENTA during PREGNANCY. These proteins may be pregnancy-specific (present only during pregnancy) or pregnancy-associated (present during pregnancy or under other conditions such as hormone therapy or certain malignancies.)

Top Publications

  1. ncbi Cytotrophoblasts up-regulate soluble fms-like tyrosine kinase-1 expression under reduced oxygen: an implication for the placental vascular development and the pathophysiology of preeclampsia
    Takeshi Nagamatsu
    Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Endocrinology 145:4838-45. 2004
  2. pmc Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia
    Sharon E Maynard
    Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02115, USA
    J Clin Invest 111:649-58. 2003
  3. ncbi Syncytin is a captive retroviral envelope protein involved in human placental morphogenesis
    S Mi
    Genetics Institute, Inc, Cambridge, Massachusetts 02140, USA
    Nature 403:785-9. 2000
  4. ncbi Circulating angiogenic factors and the risk of preeclampsia
    Richard J Levine
    Division of Epidemiology, Statistics, and Prevention Research, National Institute of Child Health and Human Development, Department of Health and Human Services, Bethesda, MD 20892, USA
    N Engl J Med 350:672-83. 2004
  5. ncbi Synergism between vascular endothelial growth factor and placental growth factor contributes to angiogenesis and plasma extravasation in pathological conditions
    P Carmeliet
    The Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, KU Leuven, Leuven, Belgium
    Nat Med 7:575-83. 2001
  6. ncbi Soluble endoglin and other circulating antiangiogenic factors in preeclampsia
    Richard J Levine
    Division of Epidemiology, Statistics, and Prevention Research, National Institute of Child Health and Human Development, Department of Health and Human Services, Bethesda, MD 20892, USA
    N Engl J Med 355:992-1005. 2006
  7. ncbi FLT1 and its ligands VEGFB and PlGF: drug targets for anti-angiogenic therapy?
    Christian Fischer
    Department of Hepatology and Gastroenterology, Charite Universitatsmedizin, Berlin, Germany
    Nat Rev Cancer 8:942-56. 2008
  8. pmc Angiogenic factors and the risk of adverse outcomes in women with suspected preeclampsia
    Sarosh Rana
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Kirstein 382, Boston, MA 02215, USA
    Circulation 125:911-9. 2012
  9. pmc Expression of a functional VEGFR-1 in tumor cells is a major determinant of anti-PlGF antibodies efficacy
    Jenny Yao
    Genentech, Inc, South San Francisco, CA 94080, USA
    Proc Natl Acad Sci U S A 108:11590-5. 2011
  10. ncbi Antitumor activity and biomarker analysis of sunitinib in patients with bevacizumab-refractory metastatic renal cell carcinoma
    Brian I Rini
    Department of Solid Tumor Oncology and Urology, Cleveland Clinic Taussig Cancer Institute, 9500 Euclid Avenue, Desk R35, Cleveland, OH 44195, USA
    J Clin Oncol 26:3743-8. 2008

Research Grants

  1. REGULATION OF OTP-1 AND HCG GENES IN OVINE TROPHOBLAST
    George Seidel; Fiscal Year: 1993
  2. OVINE INTERFERON-TAU REGULATES UTERINE HORMONE RECEPTOR
    Fuller Bazer; Fiscal Year: 2005
  3. Bridges to the Doctorate in Reproductive Biology
    Fuller Bazer; Fiscal Year: 2008
  4. Relationship between diet and sex of offspring
    Robert Roberts; Fiscal Year: 2008
  5. Transcription Factors in Trophectoderm Differentiation
    Robert Roberts; Fiscal Year: 2007
  6. INTERACTION BETWEEN BLASTOCYST AND UTERINE ENDOMETRIUM
    ROBERT MICHAEL ROBERTS; Fiscal Year: 2010
  7. DECIDUALIZATION IN THE BABOON
    Asgerally Fazleabas; Fiscal Year: 2003
  8. 2004 Reproductive Tract Biology Gordon Conference
    Asgerally Fazleabas; Fiscal Year: 2004
  9. Tumor-reactive IgG in the diagnosis of ovarian cancer
    Douglas Taylor; Fiscal Year: 2005
  10. PLAC1 in Placental Development
    Michael Fant; Fiscal Year: 2007

Detail Information

Publications277 found, 100 shown here

  1. ncbi Cytotrophoblasts up-regulate soluble fms-like tyrosine kinase-1 expression under reduced oxygen: an implication for the placental vascular development and the pathophysiology of preeclampsia
    Takeshi Nagamatsu
    Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Endocrinology 145:4838-45. 2004
    ..The presented findings might provide a framework with which to understand the mechanism of uterine vascular remodeling and its perturbations as exemplified in preeclampsia...
  2. pmc Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia
    Sharon E Maynard
    Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02115, USA
    J Clin Invest 111:649-58. 2003
    ..These observations suggest that excess circulating sFlt1 contributes to the pathogenesis of preeclampsia...
  3. ncbi Syncytin is a captive retroviral envelope protein involved in human placental morphogenesis
    S Mi
    Genetics Institute, Inc, Cambridge, Massachusetts 02140, USA
    Nature 403:785-9. 2000
    ..Our data indicate that syncytin may mediate placental cytotrophoblast fusion in vivo, and thus may be important in human placental morphogenesis...
  4. ncbi Circulating angiogenic factors and the risk of preeclampsia
    Richard J Levine
    Division of Epidemiology, Statistics, and Prevention Research, National Institute of Child Health and Human Development, Department of Health and Human Services, Bethesda, MD 20892, USA
    N Engl J Med 350:672-83. 2004
    ..Limited data suggest that excess circulating soluble fms-like tyrosine kinase 1 (sFlt-1), which binds placental growth factor (PlGF) and vascular endothelial growth factor (VEGF), may have a pathogenic role...
  5. ncbi Synergism between vascular endothelial growth factor and placental growth factor contributes to angiogenesis and plasma extravasation in pathological conditions
    P Carmeliet
    The Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, KU Leuven, Leuven, Belgium
    Nat Med 7:575-83. 2001
    ..By upregulating PlGF and the signaling subtype of VEGFR-1, endothelial cells amplify their responsiveness to VEGF during the 'angiogenic switch' in many pathological disorders...
  6. ncbi Soluble endoglin and other circulating antiangiogenic factors in preeclampsia
    Richard J Levine
    Division of Epidemiology, Statistics, and Prevention Research, National Institute of Child Health and Human Development, Department of Health and Human Services, Bethesda, MD 20892, USA
    N Engl J Med 355:992-1005. 2006
    ..Since soluble endoglin, another antiangiogenic protein, acts together with sFlt1 to induce a severe preeclampsia-like syndrome in pregnant rats, we examined whether it is associated with preeclampsia in women...
  7. ncbi FLT1 and its ligands VEGFB and PlGF: drug targets for anti-angiogenic therapy?
    Christian Fischer
    Department of Hepatology and Gastroenterology, Charite Universitatsmedizin, Berlin, Germany
    Nat Rev Cancer 8:942-56. 2008
    ..Hopefully, other agents with complementary mechanisms, such as those that target placental growth factor, will offer novel opportunities for improved treatment...
  8. pmc Angiogenic factors and the risk of adverse outcomes in women with suspected preeclampsia
    Sarosh Rana
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Kirstein 382, Boston, MA 02215, USA
    Circulation 125:911-9. 2012
    ..An imbalance in circulating angiogenic factors plays a central role in the pathogenesis of preeclampsia...
  9. pmc Expression of a functional VEGFR-1 in tumor cells is a major determinant of anti-PlGF antibodies efficacy
    Jenny Yao
    Genentech, Inc, South San Francisco, CA 94080, USA
    Proc Natl Acad Sci U S A 108:11590-5. 2011
    ..Collectively, these findings suggest that the role of PlGF in tumorigenesis largely consists of promoting autocrine/paracrine growth of tumor cells expressing a functional VEGFR-1 rather than stimulation of angiogenesis...
  10. ncbi Antitumor activity and biomarker analysis of sunitinib in patients with bevacizumab-refractory metastatic renal cell carcinoma
    Brian I Rini
    Department of Solid Tumor Oncology and Urology, Cleveland Clinic Taussig Cancer Institute, 9500 Euclid Avenue, Desk R35, Cleveland, OH 44195, USA
    J Clin Oncol 26:3743-8. 2008
    ..To assess the safety and efficacy of sunitinib in patients with bevacizumab-refractory metastatic renal cell carcinoma (mRCC) and explore biomarkers for sunitinib response...
  11. ncbi Revascularization of ischemic tissues by PlGF treatment, and inhibition of tumor angiogenesis, arthritis and atherosclerosis by anti-Flt1
    Aernout Luttun
    Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, University of Leuven, Leuven, Belgium
    Nat Med 8:831-40. 2002
    ..Thus, PlGF and Flt1 constitute potential candidates for therapeutic modulation of angiogenesis and inflammation...
  12. ncbi Human endogenous retrovirus glycoprotein-mediated induction of redox reactants causes oligodendrocyte death and demyelination
    Joseph M Antony
    Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta T2N 4N1, Canada
    Nat Neurosci 7:1088-95. 2004
    ..Thus, syncytin's proinflammatory properties in the nervous system demonstrate a novel role for an endogenous retrovirus protein, which may be a target for therapeutic intervention...
  13. ncbi Role of retrotransposon-derived imprinted gene, Rtl1, in the feto-maternal interface of mouse placenta
    Yoichi Sekita
    Department of Epigenetics, Medical Research Institute, Tokyo Medical and Dental University, 2 3 10 Kandasurugadai, Chiyoda ku, Tokyo 101 0062, Japan
    Nat Genet 40:243-8. 2008
    ....
  14. pmc Human pregnancy specific beta-1-glycoprotein 1 (PSG1) has a potential role in placental vascular morphogenesis
    Cam T Ha
    Department of Pathology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814, USA
    Biol Reprod 83:27-35. 2010
    ....
  15. ncbi The vascular endothelial growth factor family in adverse pregnancy outcomes
    P H Andraweera
    Discipline of Obstetrics and Gynaecology, Robinson Institute, University of Adelaide, Adelaide 5005, Australia
    Hum Reprod Update 18:436-57. 2012
    ..We aimed to elucidate the role of these angiogenic factors in placentation and to evaluate the predictive value of their protein concentrations and genetic variations in pregnancy complications...
  16. ncbi Redefined nomenclature for members of the carcinoembryonic antigen family
    N Beauchemin
    McGill Cancer Centre, McGill University, Montreal, Qué Canada H3G 1Y6
    Exp Cell Res 252:243-9. 1999
  17. ncbi Further pharmacological and genetic evidence for the efficacy of PlGF inhibition in cancer and eye disease
    Sara Van de Veire
    Vesalius Research Center, KU Leuven, Leuven B 3000, Belgium
    Cell 141:178-90. 2010
    ..Further, we show that PlGF blockage inhibits vessel abnormalization rather than density in certain tumors while enhancing VEGF-targeted inhibition in ocular disease. Our findings warrant further testing of anti-PlGF therapies...
  18. ncbi Maternal serum placental growth factor at 11 + 0 to 13 + 6 weeks of gestation in the prediction of pre-eclampsia
    R Akolekar
    Harris Birthright Research Centre for Fetal Medicine, King s College Hospital, London, UK
    Ultrasound Obstet Gynecol 32:732-9. 2008
    ..To investigate the potential value of maternal serum placental growth factor (PlGF) in first-trimester screening for pre-eclampsia (PE)...
  19. ncbi Impaired cell fusion and differentiation in placentae from patients with intrauterine growth restriction correlate with reduced levels of HERV envelope genes
    Matthias Ruebner
    Department of Gynaecology and Obstetrics, Laboratory for Molecular Medicine, University Clinic Erlangen, Universitaetsstr 21 23, 91054, Erlangen, Germany
    J Mol Med (Berl) 88:1143-56. 2010
    ..Fusogenic and non-fusogenic envelope genes are dysregulated in IUGR placentae and may contribute to the etiology of growth restriction in utero...
  20. pmc A longitudinal study of angiogenic (placental growth factor) and anti-angiogenic (soluble endoglin and soluble vascular endothelial growth factor receptor-1) factors in normal pregnancy and patients destined to develop preeclampsia and deliver a small for
    Roberto Romero
    Perinatology Research Branch, National Institute of Child Health and Human Development, NIH DHHS, Bethesda, MD 20892, USA
    J Matern Fetal Neonatal Med 21:9-23. 2008
    ....
  21. pmc Ancestral capture of syncytin-Car1, a fusogenic endogenous retroviral envelope gene involved in placentation and conserved in Carnivora
    Guillaume Cornelis
    Unité des rétrovirus endogènes et éléments rétroïdes des eucaryotes supérieurs, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 8122, Institut Gustave Roussy, F 94805 Villejuif, France
    Proc Natl Acad Sci U S A 109:E432-41. 2012
    ..This gene is the oldest syncytin gene identified to date, and it is the first in a new major clade of eutherian mammals...
  22. pmc Tail-interacting protein TIP47 is a connector between Gag and Env and is required for Env incorporation into HIV-1 virions
    Sandra Lopez-Verges
    Institut Cochin, Département Maladies Infectieuses, 27 rue du Faubourg Saint Jacques, F 75014 Paris, France
    Proc Natl Acad Sci U S A 103:14947-52. 2006
    ....
  23. ncbi TIP47: a cargo selection device for mannose 6-phosphate receptor trafficking
    E Diaz
    Department of Biochemistry, Stanford University School of Medicine, California 94305 5307, USA
    Cell 93:433-43. 1998
    ..These data suggest that TIP47 binds MPR cytoplasmic domains and facilitates their collection into transport vesicles destined for the Golgi...
  24. pmc Placental syncytins: Genetic disjunction between the fusogenic and immunosuppressive activity of retroviral envelope proteins
    Marianne Mangeney
    Unité des rétrovirus endogènes et éléments rétroïdes des eucaryotes supérieurs, Unité Mixte de Recherche 8122, Centre National de la Recherche Scientifique, Institut Gustave Roussy, F 94805 Villejuif, France
    Proc Natl Acad Sci U S A 104:20534-9. 2007
    ..Selective inactivation of immunosuppression, under conditions not affecting fusogenicity, should be important for understanding the role of this function in placental physiology and maternofetal tolerance...
  25. ncbi Low maternal serum levels of placenta growth factor as an antecedent of clinical preeclampsia
    S C Tidwell
    Department of Obstetrics and Gynecology, University of Tennessee Graduate School of Medicine, Knoxville, USA
    Am J Obstet Gynecol 184:1267-72. 2001
    ....
  26. ncbi Preoperative serum placenta growth factor level is a prognostic biomarker in colorectal cancer
    Shu Chen Wei
    Department of Internal Medicine, National Taiwan University Hospital and College of Medicine, Taipei, Taiwan
    Dis Colon Rectum 52:1630-6. 2009
    ..The aims of this study are to examine the prognostic value of serum placenta growth factor, vascular endothelial growth factor, and sFlt-1 and to compare them with the carcinoembryonic antigen levels in patients with colorectal cancer...
  27. ncbi Impaired cytotrophoblast cell-cell fusion is associated with reduced Syncytin and increased apoptosis in patients with placental dysfunction
    Manuela Langbein
    Department of Gynaecology and Obstetrics, Laboratory for Molecular Medicine, Erlangen, Germany
    Mol Reprod Dev 75:175-83. 2008
    ..These processes could contribute to the development and severity of PE and HELLP-associated IUGR...
  28. ncbi Expression of HERV-W Env glycoprotein (syncytin) in the extravillous trophoblast of first trimester human placenta
    A Malassine
    INSERM U427, Faculte des Sciences Pharmaceutiques et Biologiques, Université Renée Descartes, France
    Placenta 26:556-62. 2005
    ..HERV-W Env glycoprotein expressed in villous and extravillous trophoblast can be considered as a specific marker of the human trophoblast...
  29. ncbi PLAC1, an Xq26 gene with placenta-specific expression
    M Cocchia
    Laboratory of Genetics, National Institute on Aging, 5600 Nathan Shock Drive, Baltimore, Maryland 21224, USA
    Genomics 68:305-12. 2000
    ..These results make PLAC1 a marker for placental development, with a possible role in the establishment of the mother-fetus interface...
  30. ncbi Radioimmunoassay of a bovine pregnancy-associated glycoprotein in serum: its application for pregnancy diagnosis
    A P Zoli
    , , , Belgique
    Biol Reprod 46:83-92. 1992
    ..These results suggest that detection of this placental-specific antigen in the serum could be used as a specific serological method for early pregnancy diagnosis in cattle from 28 days after breeding...
  31. ncbi Effects of time of progesterone supplementation on embryo development and interferon-tau production in the cow
    G E Mann
    Division of Animal Physiology, School of Biosciences, University of Nottingham, Sutton Bonington, Loughborough LE12 5RD, UK
    Vet J 171:500-3. 2006
    ..05). The results demonstrate that progesterone supplementation during the postovulatory rise, but not later in the luteal phase, increases embryo development and interferon-tau production...
  32. ncbi Regulation of the human endogenous retroviral Syncytin-1 and cell-cell fusion by the nuclear hormone receptors PPARγ/RXRα in placentogenesis
    Matthias Ruebner
    Department of Gynaecology and Obstetrics, University Clinic Erlangen, Erlangen, Germany
    J Cell Biochem 113:2383-96. 2012
    ..Our study characterized PPARγ/RXRα signaling in human CT and cell fusions identifying Syncytin-1 as a new target gene. Based on these results, a disturbed PPARγ/RXRα pathway could contribute to pathological human pregnancies...
  33. ncbi Circulating angiogenic factors and their association with birth outcomes in preeclampsia
    Asmita V Kulkarni
    Department of Nutritional Medicine, Interactive Research School for Health Affairs, Bharati Vidyapeeth University, Pune, India
    Hypertens Res 33:561-7. 2010
    ..Increased oxidative stress may reduce cord DHA levels and increase sFlt-1 levels, leading to poor birth outcomes in preeclampsia...
  34. pmc Syncytin-A knockout mice demonstrate the critical role in placentation of a fusogenic, endogenous retrovirus-derived, envelope gene
    Anne Dupressoir
    Unité des rétrovirus endogènes et éléments rétroïdes des eucaryotes supérieurs, Unité Mixte de Recherche 8122, Centre National de Recherche Scientifique, Institut Gustave Roussy, 94805 Villejuif, and Université Paris Sud, 91405 Orsay, France
    Proc Natl Acad Sci U S A 106:12127-32. 2009
    ....
  35. ncbi Prospective study of placental angiogenic factors and maternal vascular function before and after preeclampsia and gestational hypertension
    Muna Noori
    Division of Surgery, Imperial College, Chelsea and Westminster Hospital, London, UK
    Circulation 122:478-87. 2010
    ..To elucidate the pathogenesis, we evaluated the temporal relationships between changes in vascular function and circulating biomarkers of angiogenic activity before and after the onset of preeclampsia and gestational hypertension...
  36. pmc Identification of an endogenous retroviral envelope gene with fusogenic activity and placenta-specific expression in the rabbit: a new "syncytin" in a third order of mammals
    Odile Heidmann
    Unité des rétrovirus endogènes et éléments rétroïdes des eucaryotes supérieurs, CNRS UMR 8122, Institut Gustave Roussy, 39 rue Camille Desmoulins, F 94805 Villejuif, and Université Paris Sud, Orsay, F 91405, France
    Retrovirology 6:107. 2009
    ..Two of these genes have already been identified in primates, as well as two distinct, non orthologous genes in rodents...
  37. ncbi First trimester placental growth factor and soluble fms-like tyrosine kinase 1 and risk for preeclampsia
    Ravi Thadhani
    Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 89:770-5. 2004
    ..7-fold (95% confidence interval, 2.3-351.0) in the third (<12 pg/ml) compared with the first (>39 pg/ml) PlGF tertile. First trimester serum levels of PlGF and sFlt1 may identify women at high risk for PE...
  38. ncbi Proliferation and cell-cell fusion of endometrial carcinoma are induced by the human endogenous retroviral Syncytin-1 and regulated by TGF-beta
    Reiner Strick
    Department of Gynaecology and Obstetrics, Laboratory for Molecular Medicine, University Clinic Erlangen, Universitaetsstr 21 23, 91054, Erlangen, Germany
    J Mol Med (Berl) 85:23-38. 2007
    ..Interactions between Syncytin-1 and TGF-beta may contribute to the etiology of EnCa progression and also help to clarify the regulation of cell-cell fusions occurring in development and in other syncytial cell tumors...
  39. pmc A prospective cohort study of the value of maternal plasma concentrations of angiogenic and anti-angiogenic factors in early pregnancy and midtrimester in the identification of patients destined to develop preeclampsia
    Juan Pedro Kusanovic
    Perinatology Research Branch, NICHD NIH DHHS, Bethesda, Maryland, USA
    J Matern Fetal Neonatal Med 22:1021-38. 2009
    ..This study was conducted to examine the role of maternal plasma PlGF, sEng, and sVEGFR-1 concentrations in early pregnancy and midtrimester in the identification of patients destined to develop preeclampsia...
  40. ncbi GCMa regulates the syncytin-mediated trophoblastic fusion
    Chenchou Yu
    Institute of Biological Chemistry, Academia Sinica, Nankang, Taipei 115, Taiwan
    J Biol Chem 277:50062-8. 2002
    ..Our results may help to explain the mechanism underlying the cell fusion event specific for syncytiotrophoblast formation...
  41. ncbi PlGF blockade does not inhibit angiogenesis during primary tumor growth
    Carlos Bais
    Genentech, Inc, 1 DNA Way, South San Francisco, CA 94080, USA
    Cell 141:166-77. 2010
    ..In conclusion, our data argue against an important role of PlGF during primary tumor growth in most models and suggest that clinical evaluation of anti-PlGF antibodies may be challenging...
  42. ncbi Longitudinal serum concentrations of placental growth factor: evidence for abnormal placental angiogenesis in pathologic pregnancies
    Robert N Taylor
    Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Francisco, CA 94143, USA
    Am J Obstet Gynecol 188:177-82. 2003
    ....
  43. ncbi Light and electron microscope immunocytochemical studies of the distribution of pregnancy associated glycoproteins (PAGs) throughout pregnancy in the cow: possible functional implications
    F B P Wooding
    Physiology Department, Cambridge University, Downing Street, Cambridge, UK
    Placenta 26:807-27. 2005
    ..At this location in the developing maternal villi of the placentomes, they are ideally positioned to manipulate the maternal immune system to facilitate a successful pregnancy...
  44. ncbi Automated assays for sVEGF R1 and PlGF as an aid in the diagnosis of preterm preeclampsia: a prospective clinical study
    Shiraz Sunderji
    Department of Maternal Fetal Medicine, The Toledo Hospital, OH 43606, USA
    Am J Obstet Gynecol 202:40.e1-7. 2010
    ..The purpose of this study was to assess the utility of soluble vascular endothelial growth factor 1 (sVEGF R1) and placental growth factor (PlGF) levels in the clinical diagnosis of preeclampsia...
  45. ncbi Circulating angiogenic factors in the pathogenesis and prediction of preeclampsia
    Chun Lam
    Renal Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    Hypertension 46:1077-85. 2005
    ..This review will summarize our current understanding of the role of circulating angiogenic proteins in the pathogenesis and clinical diagnosis/prediction of preeclampsia...
  46. ncbi Role of PlGF in the intra- and intermolecular cross talk between the VEGF receptors Flt1 and Flk1
    Monica Autiero
    The Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, KULeuven, Leuven, B 3000, Belgium
    Nat Med 9:936-43. 2003
    ....
  47. pmc Placenta growth factor in diabetic wound healing: altered expression and therapeutic potential
    Francesca Cianfarani
    Laboratory of Molecular and Cell Biology, Istituto Dermopatico dell Immacolata, IDI IRCCS, Via dei Monti di Creta, 104, 00167 Rome, Italy
    Am J Pathol 169:1167-82. 2006
    ....
  48. ncbi VEGF/PLGF induces leukemia cell migration via P38/ERK1/2 kinase pathway, resulting in Rho GTPases activation and caveolae formation
    C Casalou
    Leukemia 21:1590-4. 2007
  49. ncbi Human endogenous retrovirus-W envelope (syncytin) is expressed in both villous and extravillous trophoblast populations
    A Muir
    Research Group in Human Reproductive Immunobiology, Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK
    J Gen Virol 87:2067-71. 2006
    ..It was also present in ectopic trophoblast from tubal implantations. This study confirms that syncytin is expressed widely by a variety of normal human trophoblast populations, as well as choriocarcinoma cell lines...
  50. ncbi Changes in interleukin-6 and IGF system and their relationships in placenta and cord blood in newborns with fetal growth restriction compared with controls
    Maria E Street
    Department of Pediatrics, University of Parma, Italy
    Eur J Endocrinol 155:567-74. 2006
    ..It is unknown whether these occur in the placenta. The aim of this study was to assess whether interleukin-6 (IL-6) modulated the IGF system...
  51. ncbi Enhancement of placenta growth factor expression by oncostatin M in human rheumatoid arthritis synovial fibroblasts
    Huang Ju Tu
    Department of Pharmacology, College of Medicine, National Taiwan University, Taipei, Taiwan
    J Cell Physiol 228:983-90. 2013
    ..These findings demonstrated the important role of OSM in the pathology network of RA and provided novel therapeutic drug targets for RA treatment...
  52. ncbi The value of a single combined measurement of VEGF, glycodelin, progesterone, PAPP-A, HPL and LIF for differentiating between ectopic and abnormal intrauterine pregnancy
    A Daponte
    Department of Obstetrics and Gynaecology, University of Thessalia, Larissa, Greece
    Hum Reprod 20:3163-6. 2005
    ....
  53. ncbi Evaluation of a new and automated electrochemiluminescence immunoassay for plasma sFlt-1 and PlGF levels in women with preeclampsia
    Akihide Ohkuchi
    Department of Obstetrics and Gynecology, Jichi Medical University School of Medicine, Shimotsuke shi, Tochigi, Japan
    Hypertens Res 33:422-7. 2010
    ..In conclusion, measurement of the plasma sFlt-1/PlGF ratio determined by Elecsys sFlt-1 and Elecsys PlGF and using a cutoff value of 45 might assist in the diagnosis of preeclampsia, especially for early-onset preeclampsia...
  54. ncbi Regulation of blastocyst migration, apposition, and initial adhesion by a chemokine, interferon gamma-inducible protein 10 kDa (IP-10), during early gestation
    Kentaro Nagaoka
    Laboratory of Animal Breeding, Faculty of Agriculture, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    J Biol Chem 278:29048-56. 2003
    ..These findings suggest that endometrial IP-10 regulates the establishment of apical interactions between trophoblast and epithelial cells during early gestation...
  55. ncbi Effect of pregnancy and progesterone concentration on expression of genes encoding for transporters or secreted proteins in the bovine endometrium
    N Forde
    School of Agriculture, Food Science and Veterinary Medicine, University College Dublin, Belfield, Dublin, Ireland
    Physiol Genomics 41:53-62. 2010
    ....
  56. ncbi Prostaglandins regulate conceptus elongation and mediate effects of interferon tau on the ovine uterine endometrium
    Piotr Dorniak
    Center for Animal Biotechnology and Genomics, Department of Animal Science, Texas A and M University, College Station, USA
    Biol Reprod 84:1119-27. 2011
    ..Thus, PGs are important regulators of conceptus elongation and mediators of endometrial responses to progesterone and IFNT in the ovine uterus...
  57. pmc Soluble fms-Like tyrosine kinase 1 (sFlt1), endoglin and placental growth factor (PlGF) in preeclampsia among high risk pregnancies
    Robert W Powers
    Department of Obstetrics, Gynecology and Women s Health, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 5:e13263. 2010
    ..The objective of this study was to investigate whether similar changes can be detected in pregnant women at high-risk to develop the syndrome...
  58. pmc Placental growth factor mediates aldosterone-dependent vascular injury in mice
    Iris Z Jaffe
    Molecular Cardiology Research Institute, Tufts Medical Center, Boston, Massachusetts 02111, USA
    J Clin Invest 120:3891-900. 2010
    ....
  59. ncbi Highly specific monoclonal antibody demonstrates that pregnancy-specific glycoprotein (PSG) is limited to syncytiotrophoblast in human early and term placenta
    G Q Zhou
    Department of Immunology, Umea University, Sweden
    Placenta 18:491-501. 1997
    ..This staining was most likely due to cross-reactivity with biliary glycoprotein (BGP)...
  60. ncbi Ovine interferon tau suppresses transcription of the estrogen receptor and oxytocin receptor genes in the ovine endometrium
    T E Spencer
    Department of Animal Science, Texas A and M University, College Station, TX 77843 2471, USA
    Endocrinology 137:1144-7. 1996
    ....
  61. ncbi Accuracy of circulating placental growth factor, vascular endothelial growth factor, soluble fms-like tyrosine kinase 1 and soluble endoglin in the prediction of pre-eclampsia: a systematic review and meta-analysis
    C E Kleinrouweler
    Department of Obstetrics and Gynaecology, Academic Medical Center, Amsterdam, The Netherlands
    BJOG 119:778-87. 2012
    ..Biomarkers have been proposed for identification of women at increased risk of developing pre-eclampsia...
  62. ncbi Prognostic impact of placenta growth factor and vascular endothelial growth factor A in patients with breast cancer
    Else Maae
    Department of Oncology, Vejle Hospital, Kabbeltoft 25, 7100 Vejle, Denmark
    Breast Cancer Res Treat 133:257-65. 2012
    ..In conclusion, our results support the mutual relationship between PlGF and VEGF-A and encourage further investigations as prognostic markers in breast cancer patients...
  63. pmc Placental growth factor regulates cardiac adaptation and hypertrophy through a paracrine mechanism
    Federica Accornero
    Howard Hughes Medical Institute, Cincinnati Children s Hospital Medical Center, 240 Albert Sabin Way, Cincinnati, OH 45229, USA
    Circ Res 109:272-80. 2011
    ....
  64. ncbi Effects of angiogenic growth factor combinations on retinal endothelial cells
    Raquel Castellon
    Ophthalmology Research Laboratories, Burns and Allen Research Institute, Cedars Sinai Medical Center, UCLA Medical School Affiliate, Los Angeles, CA 90048, USA
    Exp Eye Res 74:523-35. 2002
    ..Their effects, however, can be greatly augmented by other growth factors that alone exert little or no action. Therefore, diabetic retinal neovascularization may result from the additive or synergistic action of several growth factors...
  65. pmc Age- and disease-dependent HERV-W envelope allelic variation in brain: association with neuroimmune gene expression
    Rakesh K Bhat
    Division of Neurology, University of Alberta, Edmonton, Alberta, Canada
    PLoS ONE 6:e19176. 2011
    ..Herein, HERV-W env diversity together with Syncytin-1 abundance and host immune gene profiles were examined in the nervous system using a multiplatform approach...
  66. ncbi TIP47 associates with lipid droplets
    N E Wolins
    Department of Nutritional Sciences, Rutgers, The State University of New Jersey, New Brunswick, NJ 08901, USA
    J Biol Chem 276:5101-8. 2001
    ..Thus, we conclude that TIP47 associates with nascent lipid droplets and can be classified as a lipid droplet-associated protein...
  67. ncbi PLAC1, a trophoblast-specific gene, is expressed throughout pregnancy in the human placenta and modulated by keratinocyte growth factor
    Michael Fant
    Department of Pediatrics, University of Texas, Houston Medical School, Houston, Texas 77030, USA
    Mol Reprod Dev 63:430-6. 2002
    ..Trophoblast-specific expression throughout gestation and responsiveness to KGF are consistent with a fundamental role for PLAC1 at the maternal-fetal interface...
  68. ncbi Inhibition of placental growth factor activity reduces the severity of fibrosis, inflammation, and portal hypertension in cirrhotic mice
    Christophe Van Steenkiste
    Department of Hepatology and Gastroenterology, Ghent University Hospital, Ghent, Belgium
    Hepatology 53:1629-40. 2011
    ....
  69. ncbi Human endogenous retroviruses and multiple sclerosis: innocent bystanders or disease determinants?
    Joseph M Antony
    Hospital for Sick Children, Toronto, ON, Canada
    Biochim Biophys Acta 1812:162-76. 2011
    ....
  70. ncbi Review: Human trophoblast fusion and differentiation: lessons from trisomy 21 placenta
    G Pidoux
    INSERM, UMR S 767, Faculte des Sciences Pharmaceutiques et Biologiques, 4 avenue de l Observatoire, Paris, France
    Placenta 33:S81-6. 2012
    ..We suggest that the oxidative status of the trophoblast may regulate glycosylation of proteins, including hCG, and thereby modulate major trophoblast cell functions...
  71. ncbi Induction of endogenous interferon tau gene transcription by CDX2 and high acetylation in bovine nontrophoblast cells
    Toshihiro Sakurai
    Laboratory of Animal Breeding, Veterinary Medical Sciences, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo ku, Tokyo, Japan
    Biol Reprod 80:1223-31. 2009
    ....
  72. pmc Relationship between quantity of IFNT estimated by IFN-stimulated gene expression in peripheral blood mononuclear cells and bovine embryonic mortality after AI or ET
    Shuichi Matsuyama
    National Institute of Livestock and Grassland Science, National Agriculture and Food Research Organization, Nasushiobara 329 2793, Japan
    Reprod Biol Endocrinol 10:21. 2012
    ..The present study aims to clarify the relationship between the ability of a bovine conceptus to produce IFNT during the MRP and the conceptus's ability to establish pregnancy...
  73. ncbi Soluble FMS-like tyrosine kinase-1 (sFlt-1) and serum placental growth factor (PlGF) as biomarkers for ectopic pregnancy and missed abortion
    Alexandros Daponte
    Department of Obstetrics and Gynecology, University of Thessalia Medical School, Larissa 41222, Greece
    J Clin Endocrinol Metab 96:E1444-51. 2011
    ..Diagnosis of early pregnancy failure is hampered by the lack of reliable serological markers...
  74. pmc A pregnancy-specific glycoprotein is expressed in the brain and serves as a receptor for mouse hepatitis virus
    D S Chen
    Howard Hughes Medical Institute, School of Medicine, University of Southern California, Los Angeles 90033 1054, USA
    Proc Natl Acad Sci U S A 92:12095-9. 1995
    ..The identification of this virus in receptor utilization. The identification of a PSG predominantly expressed in the brain also expands the potential functions of these molecules...
  75. ncbi Progesterone regulation of preimplantation conceptus growth and galectin 15 (LGALS15) in the ovine uterus
    M Carey Satterfield
    Center for Animal Biotechnology and Genomics, Department of Animal Science, Texas A and M University, College Station, Texas 77843, USA
    Biol Reprod 75:289-96. 2006
    ..The advanced development of blastocysts in P4-treated ewes is hypothesized to involve early induction of specific genes in the endometrial epithelia, such as LGALS15, and undoubtedly components of uterine histotroph...
  76. ncbi From ancestral infectious retroviruses to bona fide cellular genes: role of the captured syncytins in placentation
    A Dupressoir
    Unité des rétrovirus endogènes et éléments rétroïdes des eucaryotes supérieurs, CNRS, UMR 8122, Institut Gustave Roussy, 114 rue Edouard Vaillant, 94805 Villejuif, France
    Placenta 33:663-71. 2012
    ..Finally, we speculate that the capture of a founding syncytin-like gene could have been instrumental in the dramatic transition from egg-laying to placental mammals...
  77. ncbi A longitudinal study of plasma levels of soluble fms-like tyrosine kinase 1 (sFlt1), placental growth factor (PlGF), sFlt1: PlGF ratio and vascular endothelial growth factor (VEGF-A) in normal pregnancy
    Maria Palm
    Department of Women s and Children s Health, Obstetrics and Gynecology, Uppsala University, Uppsala, Sweden
    Acta Obstet Gynecol Scand 90:1244-51. 2011
    ..To describe plasma levels of angiogenic (PlGF, VEGF-A) and anti-angiogenic (sFlt1) factors as well as the sFlt1:PlGF ratio throughout normal pregnancy and postpartum...
  78. ncbi The choriocarcinoma cell line BeWo: syncytial fusion and expression of syncytium-specific proteins
    Kristina Orendi
    Institute of Cell Biology, Histology and Embryology, Centre for Molecular Medicine, Medical University of Graz, Harrachgasse 21 VII, 8010 Graz, Austria
    Reproduction 140:759-66. 2010
    ..We postulate that CGB protein expression is not necessarily linked to syncytial fusion, and thus CGB should be used with great caution as a marker of BeWo cell fusion...
  79. ncbi Expression of syncytin in leukemia and lymphoma cells
    Yi Sun
    Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, 32 Jiaochang Donglu, Kunming 650223, China
    Leuk Res 34:1195-202. 2010
    ..Neither the transcripts nor the translated syncytin was detected in blood samples of normal individuals. In conclusion, peripheral blood syncytin may serve as a marker for leukemia and lymphoma...
  80. ncbi Placenta growth factor expression has prognostic value in malignant pleural mesothelioma
    Eugenio Pompeo
    Department of Thoracic Surgery, Tor Vergata University, Rome, Italy
    Ann Thorac Surg 88:426-31. 2009
    ..We hypothesized that PlGF is overexpressed in mesothelioma and could have prognostic value in patients treated by extrapleural pneumonectomy...
  81. ncbi Select nutrients in the ovine uterine lumen. III. Cationic amino acid transporters in the ovine uterus and peri-implantation conceptuses
    Haijun Gao
    Center for Animal Biotechnology and Genomics, Department of Animal Science, Texas A and M University, College Station, Texas 77843 2471, USA
    Biol Reprod 80:602-9. 2009
    ..These results indicate that coordinate changes in SLC7A1, SLC7A2, and SLC7A3 expression in uterine endometria and conceptuses are likely important in transport of arginine that is critical to conceptus growth, development, and survival...
  82. pmc Comparative methylation of ERVWE1/syncytin-1 and other human endogenous retrovirus LTRs in placenta tissues
    Juliette Gimenez
    Laboratoire Commun de Recherche Hospices Civils de Lyon bioMérieux, Cancer Biomarkers Research Group, 69495 Pierre Benite Cedex, France
    DNA Res 16:195-211. 2009
    ..These results suggest that HERV methylation might not be family related but copy-specific, and related to the LTR function and the tissue. In particular, ERVWE1 and ERV3 could be developmentally epigenetically regulated HERVs...
  83. ncbi Human endogenous retrovirus K (HERV-K) is expressed in villous and extravillous cytotrophoblast cells of the human placenta
    U Kammerer
    Women s Hospital, University of Wurzburg, Germany
    J Reprod Immunol 91:1-8. 2011
    ..Since retroviral TM proteins including the TM protein of HERV-K have immunosuppressive properties, expression of the TM protein of HERV-K may contribute to immune protection of the fetus...
  84. pmc Maternal plasma concentrations of angiogenic/anti-angiogenic factors are of prognostic value in patients presenting to the obstetrical triage area with the suspicion of preeclampsia
    Tinnakorn Chaiworapongsa
    Perinatology Research Branch, NICHD NIH DHHS, Bethesda, Maryland, USA
    J Matern Fetal Neonatal Med 24:1187-207. 2011
    ....
  85. pmc VEGFR1-mediated pericyte ablation links VEGF and PlGF to cancer-associated retinopathy
    Renhai Cao
    Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, 171 77 Stockholm, Sweden
    Proc Natl Acad Sci U S A 107:856-61. 2010
    ..Our findings link VEGF and PlGF to cancer-associated retinopathy, reveal the molecular mechanisms of VEGFR1 ligand-mediated retinopathy, and define VEGFR1 as an important target of antiangiogenic therapy for treatment of retinopathy...
  86. ncbi S3-12, Adipophilin, and TIP47 package lipid in adipocytes
    Nathan E Wolins
    Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 280:19146-55. 2005
    ....
  87. ncbi Effective prediction of preeclampsia by a combined ratio of angiogenesis-related factors
    Ji Hyae Lim
    Laboratory of Medical Genetics, Medical Research Institute, Cheil General Hospital and Women s Healthcare Center, Seoul, Korea
    Obstet Gynecol 111:1403-9. 2008
    ....
  88. ncbi Interferons and progesterone for establishment and maintenance of pregnancy: interactions among novel cell signaling pathways
    Fuller W Bazer
    Texas A and M University, College Station, TX 77843 2471, USA
    Reprod Biol 8:179-211. 2008
    ..The magnitude of the LH surge was reduced in cows receiving endotoxin...
  89. ncbi Syncytin-2 plays an important role in the fusion of human trophoblast cells
    Amandine Vargas
    Departement des Sciences Biologiques, Universite du Quebec a Montreal, Montreal, Quebec, Canada
    J Mol Biol 392:301-18. 2009
    ..Overall, these results highlight the importance of Syncytin-2 in BeWo and primary human trophoblast cell fusion...
  90. ncbi Expression analyses of human endogenous retroviruses (HERVs): tissue-specific and developmental stage-dependent expression of HERVs
    Goichi Okahara
    Department of Molecular Biology, Ryukyu University School of Medicine, 207 Uehara, Okinawa 903 0215, Japan
    Genomics 84:982-90. 2004
    ..Term placentas in general showed larger interindividual differences in HERV expression levels. Our results suggest that HERVs might have more diverse effects than currently thought...
  91. ncbi Expression of vascular endothelial growth factor receptors 1, 2 and 3 in placentas from normal and complicated pregnancies
    S Helske
    Department of Obstetrics and Gynaecology, Helsinki University Central Hospital, PL 140, 00290 Helsinki, Finland
    Mol Hum Reprod 7:205-10. 2001
    ..These results suggest that low maternal serum PlGF and increased placental expression of its receptor VEGFR-1 are associated with pre-eclampsia and FGR...
  92. ncbi Circulating angiogenic factors in early pregnancy and the risk of preeclampsia, intrauterine growth restriction, spontaneous preterm birth, and stillbirth
    Gordon C S Smith
    Department of Obstetrics and Gynaecology, Cambridge University, Cambridge, United Kingdom
    Obstet Gynecol 109:1316-24. 2007
    ..To estimate the relationship between maternal serum levels of placental growth factor (PlGF) and soluble fms-like tyrosine kinase-1 (sFlt-1) in early pregnancy with the risk of subsequent adverse outcome...
  93. pmc Distinct vascular endothelial growth factor signals for lymphatic vessel enlargement and sprouting
    Maria Wirzenius
    Molecular Cancer Biology Laboratory and Ludwig Institute for Cancer Research, Haartman Institute and Helsinki University Hospital, Biomedicum Helsinki, University of Helsinki, 00014 Helsinki, Finland
    J Exp Med 204:1431-40. 2007
    ..Our data suggests that VEGFR-2 signals promote lymphatic vessel enlargement, but unlike in the blood vessels, are not involved in vessel sprouting to generate new lymphatic vessels in vivo...
  94. ncbi Structure of a lipid droplet protein; the PAT family member TIP47
    Sabrina J Hickenbottom
    Laboratory of Cellular and Developmental Biology, U S Department of Health and Human Services, Bethesda, MD 20892, USA
    Structure 12:1199-207. 2004
    ..The structure suggests an analogy between PAT proteins and apolipoproteins in which helical repeats interact with lipid while the ordered C-terminal region is involved in protein:protein interactions...
  95. pmc The change in concentrations of angiogenic and anti-angiogenic factors in maternal plasma between the first and second trimesters in risk assessment for the subsequent development of preeclampsia and small-for-gestational age
    Offer Erez
    Perinatology Research Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, DHHS, Bethesda, Maryland, USA
    J Matern Fetal Neonatal Med 21:279-87. 2008
    ....
  96. ncbi Increased visfatin concentrations in women with gestational diabetes mellitus
    Katarzyna Krzyzanowska
    Department of Internal Medicine I, Rudolfstiftung Hospital, Vienna, Austria
    Clin Sci (Lond) 110:605-9. 2006
    ..001). In conclusion, visfatin is elevated in women with GDM and increases during the course of pregnancy as well as after delivery. Furthermore, visfatin shows no association with insulin and leptin in women with GDM...
  97. ncbi Markedly increased amounts of messenger RNAs for vascular endothelial growth factor and placenta growth factor in renal cell carcinoma associated with angiogenesis
    A Takahashi
    Genetics Division, National Cancer Center Research Institute, Tokyo, Japan
    Cancer Res 54:4233-7. 1994
    ..Biochem. Biophys. Res. Commun., 180: 386-392, 1991). Taken together, these results suggest that VEGF, PIGF, and basic fibroblast growth factor are cooperatively working to increase the angiogenesis in renal cell carcinoma in vivo...
  98. ncbi Pregnancy-specific glycoproteins function as immunomodulators by inducing secretion of IL-10, IL-6 and TGF-beta1 by human monocytes
    S K Snyder
    Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    Am J Reprod Immunol 45:205-16. 2001
    ..Human and murine PSGs exhibit cross-species activity. Our results are consistent with a role for PSGs in modulation of the innate immune system...
  99. ncbi Can placental growth factor in maternal circulation identify fetuses with placental intrauterine growth restriction?
    Samantha J Benton
    Department of Obstetrics and Gynaecology and the Child and Family Research Institute, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada
    Am J Obstet Gynecol 206:163.e1-7. 2012
    ..Excluding congenital syndromes, infection, and aneuploidy, we assumed IUGR with an abnormal placental pathology to be of placental origin...
  100. pmc Placental growth factor: a promising diagnostic biomarker for tubal ectopic pregnancy
    Andrew W Horne
    Centre for Reproductive Biology, Queen s Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom
    J Clin Endocrinol Metab 96:E104-8. 2011
    ..There is currently no serum test to differentiate tubal from intrauterine implantation, and an effective biomarker of ectopic pregnancy would be a major clinical advance...
  101. ncbi Elevated placental soluble vascular endothelial growth factor receptor-1 inhibits angiogenesis in preeclampsia
    Shakil Ahmad
    Department of Reproductive and Vascular Biology, The Medical School, University of Birmingham, Edgbaston, Birmingham, West Midlands B15 2TG, UK
    Circ Res 95:884-91. 2004
    ..Our finding demonstrates the dysregulation of the VEGF/PlGF axis in preeclampsia and offers an entirely new therapeutic approach to its treatment...

Research Grants66

  1. REGULATION OF OTP-1 AND HCG GENES IN OVINE TROPHOBLAST
    George Seidel; Fiscal Year: 1993
    ..If (3) is negative, determine if the regulatory region of the hCG alpha gene can express hCG alpha and beta subunits in ovine trophoblast. 5)Make transgenic sheep with two promising constructs from the above studies...
  2. OVINE INTERFERON-TAU REGULATES UTERINE HORMONE RECEPTOR
    Fuller Bazer; Fiscal Year: 2005
    ....
  3. Bridges to the Doctorate in Reproductive Biology
    Fuller Bazer; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  4. Relationship between diet and sex of offspring
    Robert Roberts; Fiscal Year: 2008
    ..abstract_text> ..
  5. Transcription Factors in Trophectoderm Differentiation
    Robert Roberts; Fiscal Year: 2007
    ..The studies are expected to reveal mechanisms underpinning the transition of embryonic stem cells to trophectoderm, a developmental event that immediately precedes implantation and a time when expression of hCG begins. ..
  6. INTERACTION BETWEEN BLASTOCYST AND UTERINE ENDOMETRIUM
    ROBERT MICHAEL ROBERTS; Fiscal Year: 2010
    ..Together these studies are expected to provide information on two key events in early pregnancy, the formation of an early placenta and immediate maternal responses to the presence of a tiny embryo attaching to her uterine wall. ..
  7. DECIDUALIZATION IN THE BABOON
    Asgerally Fazleabas; Fiscal Year: 2003
    ....
  8. 2004 Reproductive Tract Biology Gordon Conference
    Asgerally Fazleabas; Fiscal Year: 2004
    ..The continued ability to meet with the Mammalian Gametogenesis and Embryogenesis Conference at the same site will further enhance the quality of this meeting, which has consistently been highly rated by the attendees. ..
  9. Tumor-reactive IgG in the diagnosis of ovarian cancer
    Douglas Taylor; Fiscal Year: 2005
    ..Ultimately, antigenic proteins, linked with histologic type and stage of disease, will be combined into the development of protein arrays to screen for circulating reactive IgG as an early diagnostic test. ..
  10. PLAC1 in Placental Development
    Michael Fant; Fiscal Year: 2007
    ..Given the restricted nature of PLAC1/Plac1 expression, these studies will likely provide novel insights into mechanisms important in placental and fetal development. [unreadable] [unreadable] [unreadable]..
  11. The Role of PLAC1 in Placental Growth
    Michael Fant; Fiscal Year: 2003
    ..These studies will provide new insights into mechanism important to placental growth and function, and will form the basis for future studies aimed at defining the role of PLAC1 at the cellular level. ..
  12. Evolution of vertebrate sensory genes
    Jianzhi Zhang; Fiscal Year: 2010
    ..These studies will also help understand human smell and taste variations and disorders. ..
  13. MARKER ASSISTED SELECTION OF BOVINE BLASTOCYSTS
    HANS KUBISCH; Fiscal Year: 2002
    ....
  14. Novel Active Repressor Model of Human LDL-Receptor Regulation
    Johannes Veldhuis; Fiscal Year: 2008
    ..This would represent a new treatment approach for patients with atherosclerotic disease. [unreadable] [unreadable] [unreadable] [unreadable]..
  15. Ensemble Disruption of the GnRH-LH-Testosterone Axis
    Johannes Veldhuis; Fiscal Year: 2007
    ..Expected corollary outcomes are enhanced diagnosis, assessment and management of more subtle pathophysiology of the male gonadal axis in puberty and adulthood. ..
  16. Sgk1 in Na+ transport in fetal lung epithelia
    Christie Thomas; Fiscal Year: 2007
    ..abstract_text> ..
  17. Signaling Dynamics of Leukocyte-Tumor Cell Interactions
    HOWARD PETTY; Fiscal Year: 2008
    ..These new insights are likely to lead to advances in immunotherapy of cancer. ..
  18. A Pilot Trial of Oral Melatonin Supplementation in Breast Cancer Survivors
    Eva Schernhammer; Fiscal Year: 2007
    ..This pilot data could lay the groundwork for a large scale trial to assess the chemopreventive potential of melatonin in women, both with and without a personal history of breast cancer. [unreadable] [unreadable] [unreadable]..
  19. Mechanistic bases for age-related androgen deficiency
    Johannes Veldhuis; Fiscal Year: 2007
    ..Knowing why testosterone falls should help foster new and safer ways to prevent the problem. [unreadable] [unreadable] [unreadable]..
  20. Phase I Clinical Trials of Anti-Cancer Agents
    Francis Giles; Fiscal Year: 2007
    ..abstract_text> ..
  21. Clock Genes, Night Work, and Breast Cancer Risk
    Eva Schernhammer; Fiscal Year: 2008
    ..The results from this study could help identify individuals who are more susceptible to night work than others, based on their genetic profile. ..
  22. Predictors of Dietary Quality in Low-Income Pregnant Women
    Eileen R Fowles; Fiscal Year: 2010
    ..More effective targeted strategies initiated within this narrow window of time may reduce the number of low birth weight infants and improve obstetrical outcomes. ..
  23. MOLECULAR REGULATION AND ROLE OF PLACENTA GROWTH FACTOR
    Donald S Torry; Fiscal Year: 2010
    ....
  24. EVOLUTION OF IMMUNE RECOGNITION AND EVASION
    Austin L Hughes; Fiscal Year: 2010
    ..In addition, by increasing our understanding of the population diversity and evolutionary history of human immune system genes, this research will enhance our knowledge of human immune function in health and disease. ..
  25. Role of BMDCs in Solid Tumor Growth and Relapse
    Rakesh K Jain; Fiscal Year: 2010
    ..Furthermore, our results will offer strategies for the inhibition of tumor relapse after radiotherapy by targeting molecular pathways that are critical for both angiogenesis and myeloid BMDC recruitment. ..
  26. Cerebral Arteriole Function during Hyperglycemic Stroke
    Marilyn Cipolla; Fiscal Year: 2009
    ....
  27. Conceptus-Dependent Effects on the Endometrium
    Brent Bany; Fiscal Year: 2009
    ....
  28. Resistance Artery Adaptation in Hypertensive Pregnancy
    George Osol; Fiscal Year: 2009
    ..abstract_text> ..
  29. Aspartame Intake and the Risk of Cancer
    Eva Schernhammer; Fiscal Year: 2008
    ..Our results may help decision-makers formulate guidelines and direct future aspartame studies. Even a null finding would be important in this context. [unreadable] [unreadable] [unreadable]..
  30. Regulation of Maternal Fuel Supply and Neonatal Adiposity
    Linda Barbour; Fiscal Year: 2008
    ..Such information may result in new treatment strategies in pregnant women to normalize fetal growth. ..
  31. Genetic Regulation of Postnatal Uterine Morphogenesis and Function
    Thomas Spencer; Fiscal Year: 2008
    ..This research will help determine important genes for reproduction and help to design clinical therapies to prevent, identify and treat reproductive problems in women. [unreadable] [unreadable] [unreadable]..
  32. Mechanisms of myometrial healing and regeneration
    Catalin Buhimschi; Fiscal Year: 2006
    ....
  33. Mentored Patient-Oriented Research Career Development Award
    Linda Barbour; Fiscal Year: 2006
    ..abstract_text> ..
  34. Endocytosis and trafficking of PRL receptor isoforms
    Linda Schuler; Fiscal Year: 2006
    ..4. Determine the role of dimerization in this process, and the effect of homo- vs. hetero-dimerization using chimeric receptors and PRL antagonists. ..
  35. ENSEMBLE MODEL OF STRESS ACTH-ADRENAL AXIS
    Johannes Veldhuis; Fiscal Year: 2005
    ....
  36. Gene Duplication and Genome Evolution
    Austin Hughes; Fiscal Year: 2004
    ..5) Examining the role of transposable elements in duplication of genomic segments by testing for nonrandom association between these elements and putatively duplicated blocks in the yeast genome. ..
  37. MECHANISMS REGULATING UTERINE MORPHOGENESIS
    Thomas Spencer; Fiscal Year: 2004
    ....
  38. Placental Endogenous Retrovirus Expression
    Neal Rote; Fiscal Year: 2004
    ..These specific aims were chosen to address issues raised in previously unsuccessful R01 applications. ..
  39. Expression and function of PIGF in cardiomyocytes
    RONALD TORRY; Fiscal Year: 2003
    ..Collectively, these data may provide support for PIGF-mediated therapeutic approaches to facilitate coronary microvascular growth and/or reduce the cardiomyocyte loss associated with ischemic heart disease. ..
  40. Meeting of American Society for Reproductive Immunology:
    Gil Mor; Fiscal Year: 2003
    ..abstract_text> ..
  41. REPERFUSION EFFECTS ON CEREBRAL ARTERY FUNCTION
    Marilyn Cipolla; Fiscal Year: 2003
    ..Therefore, Aim 3 will investigate the effects of two types of thrombolytic agents (tissue-type and urokinase) on cerebral artery function, including myogenic processes. ..
  42. Nanoparticle delivery of antiangiogenic genes
    Gerard Lutty; Fiscal Year: 2003
    ..The goal of this proposal is to deliver genes for endogenous antiangiogenic agents to sites of ocular neovascularization. ..
  43. REGULATION OF PRIMATE ENDOMETRIAL RESPONSE
    William Okulicz; Fiscal Year: 2003
    ..The studies designed herein can potentially provide important insights into the genes that are involved in disorders of female fertility, endometrial hyperplasia, and reproductive tract cancer. ..
  44. THE AGING GH AXIS IN POSTMENOPAUSAL WOMEN
    Johannes Veldhuis; Fiscal Year: 2005
    ..An enhanced knowledge base should aid ultimately in formulating more innovative preventive and interventional strategies to limit hyposomatotropism in older and/or estrogen-deficient humans. ..
  45. Global Gene Expression in Chronic Rhinosinusitis
    DOUGLAS PLAGER; Fiscal Year: 2005
    ..These new molecular approaches should shed light on the mechanisms of CRS and open novel avenues for diagnosis and treatment of this difficult disease. ..
  46. 2002 Myogenic Centennial Conference
    George Osol; Fiscal Year: 2002
    ....
  47. REGULATION OF PROSTAGLANDIN RECEPTORS IN MYOMETRIUM
    Leslie Myatt; Fiscal Year: 2006
    ..The confocal microscopy will provide information on cellular localization of receptors and the promoter analyses will reveal potential regulatory sites for control of expression of uterine receptors at parturition. ..
  48. NITRIC OXIDE AND SUPEROXIDE INTERACTIONS IN THE PLACENTA
    Leslie Myatt; Fiscal Year: 2002
    ..5. Expression of mRNA and protein for SOD isoforms, xanthine oxidase and the cytochrome b558 subunit of NADPH oxidase in normal and pathologic placental tissues using RT-PCR and immunohistochemistry. ..
  49. Regulation of Angiogenesis via EphB4 Signaling
    JENA STEINLE; Fiscal Year: 2002
    ..These results from both mesenteric and retinal endothelial cells will greatly increase our understanding of Eph B4 receptor regulation of the various stages of angiogenesis. ..
  50. MAMMARY PROLACTIN PRODUCTION AND BREAST CANCER
    Linda Schuler; Fiscal Year: 2005
    ..These studies will increase our understanding of how these factors may cooperate in the pathogenesis of mammary neoplasia, and design of clinically useful approaches. ..
  51. Mechanisms Regulating Neutrophil Activation in Pregnancy
    HOWARD PETTY; Fiscal Year: 2005
    ..abstract_text> ..
  52. ACTIONS OF ESTROGEN IN MATURING GRAAFIAN FOLLICLES
    Johannes Veldhuis; Fiscal Year: 2005
    ..Understanding such fundamental interactions is important to the rational design of alternative strategies to interrupt normal and rescue impaired steroidogenesis in the maturing Graafian follicle and corpus luteum. ..
  53. Inhibin/Activin Family in Human Cranifocial Development
    Geralyn Messerlian; Fiscal Year: 2003
    ..abstract_text> ..
  54. MECHANOTRANSDUCTION BY VASCULAR SMOOTH MUSCLE
    George Osol; Fiscal Year: 2002
    ....
  55. Integrative Biology of Tumor Metastasis
    Rakesh Jain; Fiscal Year: 2009
    ..Finally, we have the resources and the clinical collaborators in place to initiate a clinical trial based on our findings, as attested by our ongoing trial using a VEGF-specific antibody. ..
  56. Conference on Angiogenesis in Cancer and Other Diseases
    Rakesh Jain; Fiscal Year: 2002
    ..The meeting's synthesis of available information will be particularly thought-provoking for students and post- doctoral fellows. ..
  57. Lipid droplets as sites for protein sequestration
    MICHAEL WELTE; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  58. VENOARTERIAL SIGNALING IN THE UTERINE CIRCULATION
    George Osol; Fiscal Year: 2003
    ..These studies will provide new, quantitative information on the mechanisms by which molecular signals and pregnancy modulate venous permeability and signal transfer within the uterine circulation. ..
  59. Apoptosis and Trophoblast Fusion
    NEAL STEWART ROTE; Fiscal Year: 2010
    ..We will investigate those correlations by specifically inhibiting these proteins using peptide inhibitors and gene silencing. Additional studies will evaluate the role of signal transduction through NFB. ..
  60. Antiphospholipid Antibody Heterogeneity
    Neal Rote; Fiscal Year: 2007
    ..This will be the first study to thoroughly investigate the spectrum of antiphospholipid antibodies in individual patients and correlate those data to effects on placental trophoblast. ..
  61. FLOTILLINS AND INSULIN-STIMULATED GLUCOSE TRANSPORT
    Perry Bickel; Fiscal Year: 2006
    ..Completion of these aims should yield testable hypotheses about the role of flotillin-1 in human health and disease and in the pathophysiology of type 2 diabetes. ..
  62. Anti-Angiogenesis/Drugs in Tumors--Bench /Bedside & Back
    Rakesh Jain; Fiscal Year: 2005
    ..Attendance at this conference will provide an excellent opportunity for young investigators working on cancer to educate and familiarize themselves with the field of angiogenesis and the complexities of the system. ..
  63. Combinatorial Signals & Gene Expression in Trophoblasts
    Mark Roberson; Fiscal Year: 2006
    ....
  64. REGULATION OF RENIN AND PREECLAMPTIC HYPERTENSION
    Dinesh Shah; Fiscal Year: 2001
    ..These studies will improve our understanding of the role of progesterone in the regulation of reproductive renin and may provide a novel direction for investigating the pathophysiology of preeclampsia. ..
  65. Two-photon excited fluorescence imaging of placental vasculature in vivo
    Mark Roberson; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..