proto oncogene proteins c fos

Summary

Summary: Cellular DNA-binding proteins encoded by the c-fos genes (GENES, FOS). They are involved in growth-related transcriptional control. c-fos combines with c-jun (PROTO-ONCOGENE PROTEINS C-JUN) to form a c-fos/c-jun heterodimer (TRANSCRIPTION FACTOR AP-1) that binds to the TRE (TPA-responsive element) in promoters of certain genes.

Top Publications

  1. ncbi AP-1 subunits: quarrel and harmony among siblings
    Jochen Hess
    Deutsches Krebsforschungszentrum, Division of Signal Transduction and Growth Control, 69120 Heidelberg, Germany
    J Cell Sci 117:5965-73. 2004
  2. ncbi c-Fos: a key regulator of osteoclast-macrophage lineage determination and bone remodeling
    A E Grigoriadis
    Research Institute of Molecular Pathology IMP, Vienna, Austria
    Science 266:443-8. 1994
  3. ncbi Nuclear factor of activated T-cells (NFAT) rescues osteoclastogenesis in precursors lacking c-Fos
    Koichi Matsuo
    Department of Microbiology and Immunology, School of Medicine, Keio University, Tokyo 160 8582, Japan
    J Biol Chem 279:26475-80. 2004
  4. ncbi AP-1: a double-edged sword in tumorigenesis
    Robert Eferl
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Nat Rev Cancer 3:859-68. 2003
  5. ncbi FRA-1 expression level regulates proliferation and invasiveness of breast cancer cells
    Karine Belguise
    INSERM U540, Endocrinologie Moléculaire et Cellulaire des Cancers, 60 rue de Navacelles, 34090 Montpellier, France
    Oncogene 24:1434-44. 2005
  6. pmc Cross-family dimerization of transcription factors Fos/Jun and ATF/CREB alters DNA binding specificity
    T Hai
    Department of Medical Biochemistry, Ohio State University, Columbus 43210
    Proc Natl Acad Sci U S A 88:3720-4. 1991
  7. ncbi RANKL maintains bone homeostasis through c-Fos-dependent induction of interferon-beta
    Hiroshi Takayanagi
    Department of Immunology, Faculty of Medicine and Graduate School of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 0033, Japan
    Nature 416:744-9. 2002
  8. ncbi The proto-oncoprotein c-Fos negatively regulates hepatocellular tumorigenesis
    Mario Mikula
    Institute of Cancer Research, University of Vienna, Borschke Gasse 8a, A 1090 Vienna, Austria
    Oncogene 22:6725-38. 2003
  9. ncbi Regulation of osteoclast differentiation and function by the CaMK-CREB pathway
    Kojiro Sato
    Department of Cell Signaling, Graduate School, Tokyo Medical and Dental University, Japan
    Nat Med 12:1410-6. 2006
  10. ncbi NF-kappaB p50 and p52 regulate receptor activator of NF-kappaB ligand (RANKL) and tumor necrosis factor-induced osteoclast precursor differentiation by activating c-Fos and NFATc1
    Teruhito Yamashita
    Department of Pathology and Laboratory Medicine and Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Biol Chem 282:18245-53. 2007

Research Grants

  1. Research Initiative for Scientific Enhancement 2009-2013
    PAUL T BUONORA; Fiscal Year: 2012
  2. ONTOGENY OF NEUROADAPTIVE RESPONSES TO PSYCHOSTIMULANTS
    Michelle Ehrlich; Fiscal Year: 2002
  3. Morphine-induced chronic Fra upregulation
    DANIELLA LANCELLOTTI; Fiscal Year: 2004
  4. Social Stress and Sensorimotor Gating Deficits in Rats
    RONALD HAMMER; Fiscal Year: 2006
  5. BASAL GANGLIA CIRCUITRY IMMEDIATE EARLY GENE EXPRESSION
    David Wirtshafter; Fiscal Year: 2003
  6. Lateral Hypothalamus, Dopamine and Ingestive Behavior
    David Wirtshafter; Fiscal Year: 2007
  7. Cue dependency with intravenous nutrients and nicotine
    Neil Rowland; Fiscal Year: 2007
  8. Molecular Basis of D1 and D2 Priming
    Alexia Pollack; Fiscal Year: 2003
  9. Role of Fra-1 in Mesothelioma
    Maria Ramos Nino; Fiscal Year: 2008
  10. Physiology and genetics of food procurement in rodents
    Neil Rowland; Fiscal Year: 2008

Detail Information

Publications270 found, 100 shown here

  1. ncbi AP-1 subunits: quarrel and harmony among siblings
    Jochen Hess
    Deutsches Krebsforschungszentrum, Division of Signal Transduction and Growth Control, 69120 Heidelberg, Germany
    J Cell Sci 117:5965-73. 2004
    ....
  2. ncbi c-Fos: a key regulator of osteoclast-macrophage lineage determination and bone remodeling
    A E Grigoriadis
    Research Institute of Molecular Pathology IMP, Vienna, Austria
    Science 266:443-8. 1994
    ..These results identify Fos as a key regulator of osteoclast-macrophage lineage determination in vivo and provide insights into the molecular mechanisms underlying metabolic bone diseases...
  3. ncbi Nuclear factor of activated T-cells (NFAT) rescues osteoclastogenesis in precursors lacking c-Fos
    Koichi Matsuo
    Department of Microbiology and Immunology, School of Medicine, Keio University, Tokyo 160 8582, Japan
    J Biol Chem 279:26475-80. 2004
    ..These data indicate that lack of Nfatc1 expression is the cause of the differentiation block in Fos(-/-) osteoclast precursors and that transcriptional induction of Nfatc1 is a major function of c-Fos in osteoclast differentiation...
  4. ncbi AP-1: a double-edged sword in tumorigenesis
    Robert Eferl
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Nat Rev Cancer 3:859-68. 2003
  5. ncbi FRA-1 expression level regulates proliferation and invasiveness of breast cancer cells
    Karine Belguise
    INSERM U540, Endocrinologie Moléculaire et Cellulaire des Cancers, 60 rue de Navacelles, 34090 Montpellier, France
    Oncogene 24:1434-44. 2005
    ..These overall results show that high Fra-1 expression is associated with a more malignant cell phenotype and suggest that Fra-1 could have a pivotal role in breast cancer progression...
  6. pmc Cross-family dimerization of transcription factors Fos/Jun and ATF/CREB alters DNA binding specificity
    T Hai
    Department of Medical Biochemistry, Ohio State University, Columbus 43210
    Proc Natl Acad Sci U S A 88:3720-4. 1991
    ..These findings indicate that the Fos/Jun and ATF/CREB families of transcription factors are not as distinct as was previously thought. We suggest that they can be grouped into a superfamily of transcription factors...
  7. ncbi RANKL maintains bone homeostasis through c-Fos-dependent induction of interferon-beta
    Hiroshi Takayanagi
    Department of Immunology, Faculty of Medicine and Graduate School of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 0033, Japan
    Nature 416:744-9. 2002
    ..Our study places the IFN-beta system in a new context, and may offer a molecular basis for the treatment of bone diseases...
  8. ncbi The proto-oncoprotein c-Fos negatively regulates hepatocellular tumorigenesis
    Mario Mikula
    Institute of Cancer Research, University of Vienna, Borschke Gasse 8a, A 1090 Vienna, Austria
    Oncogene 22:6725-38. 2003
    ..Taken together, we demonstrate that c-Fos modulates plasticity of epithelial hepatocytes and acts tumour suppressive in neoplastic hepatocytes by stimulating cell cycle inhibition and cell death...
  9. ncbi Regulation of osteoclast differentiation and function by the CaMK-CREB pathway
    Kojiro Sato
    Department of Cell Signaling, Graduate School, Tokyo Medical and Dental University, Japan
    Nat Med 12:1410-6. 2006
    ..This provides a molecular basis for a new therapeutic strategy for bone diseases...
  10. ncbi NF-kappaB p50 and p52 regulate receptor activator of NF-kappaB ligand (RANKL) and tumor necrosis factor-induced osteoclast precursor differentiation by activating c-Fos and NFATc1
    Teruhito Yamashita
    Department of Pathology and Laboratory Medicine and Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Biol Chem 282:18245-53. 2007
    ..Inhibition of NF-kappaB should prevent RANKL- and TNF-induced bone resorption...
  11. ncbi Pdcd4 suppresses tumor phenotype in JB6 cells by inhibiting AP-1 transactivation
    Hsin Sheng Yang
    Gene Regulation Section, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA
    Oncogene 22:3712-20. 2003
    ..Thus, Pdcd4 suppresses tumor phenotype by inhibiting AP-1-dependent transcription, possibly through inhibiting c-Jun and c-Fos activation...
  12. pmc IL-1ra alleviates inflammatory hyperalgesia through preventing phosphorylation of NMDA receptor NR-1 subunit in rats
    Rui Xin Zhang
    Center for Integrative Medicine, School of Medicine, University of Maryland, Baltimore, MD 21201, USA
    Pain 135:232-9. 2008
    ..05) and inhibited NR1 phosphorylation compared to saline control. The results suggest that spinal IL-1beta is produced by astrocytes and enhances NR1 phosphorylation to facilitate inflammatory pain...
  13. ncbi Fos-related antigen 1 modulates malignant features of glioma cells
    Waldemar Debinski
    Brain Tumor Center of Excellence, Department of Neurosurgery, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Mol Cancer Res 3:237-49. 2005
    ..Thus, Fra-1 may likely play an important role in the maintenance/progression of malignant gliomas and potentially represents a new target for therapeutic interventions...
  14. ncbi Nesfatin-1 neurons in paraventricular and supraoptic nuclei of the rat hypothalamus coexpress oxytocin and vasopressin and are activated by refeeding
    Daisuke Kohno
    Division of Integrative Physiology, Department of Physiology, Jichi Medical University, School of Medicine, Tochigi 329 0498, Japan
    Endocrinology 149:1295-301. 2008
    ..Feeding-activated nesfatin-1 neurons in the PVN and SON could play a role in the postprandial regulation of feeding behavior and energy homeostasis...
  15. ncbi Reduced food anticipatory activity in genetically orexin (hypocretin) neuron-ablated mice
    Masashi Akiyama
    Department of Pharmacology, School of Science and Engineering, Waseda University, 2 7 5 Higashifushimi, Nishitokyo, 202 0021, Japan
    Eur J Neurosci 20:3054-62. 2004
    ..Based on these results, we suggest that activity of the orexin neuron in the LHA contributes to the promotion and maintenance of FAA...
  16. ncbi Fos-related antigen (Fra-1), junB, and junD activate human involucrin promoter transcription by binding to proximal and distal AP1 sites to mediate phorbol ester effects on promoter activity
    J F Welter
    Department of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106 4970, USA
    J Biol Chem 270:12614-22. 1995
    ....
  17. ncbi FOS-1 promotes basement-membrane removal during anchor-cell invasion in C. elegans
    David R Sherwood
    HHMI and Division of Biology, California Institute of Technology, 1200 East California Boulevard, Pasadena, California 91125, USA
    Cell 121:951-62. 2005
    ..These results reveal a key genetic network that controls basement-membrane removal during cell invasion...
  18. ncbi Prognostic significance of loss of c-fos protein in gastric carcinoma
    Seon Pil Jin
    Department of Pathology, Seoul National University College of Medicine, Seoul, Korea
    Pathol Oncol Res 13:284-9. 2007
    ..The above findings suggest that loss of c-fos expression has tumor suppressor activity in gastric cancer and we suspect that this suppressor activity might be related to the pro-apoptotic function of c-fos...
  19. pmc Phosphorylation of the carboxyl-terminal transactivation domain of c-Fos by extracellular signal-regulated kinase mediates the transcriptional activation of AP-1 and cellular transformation induced by platelet-derived growth factor
    Paula Monje
    Oral and Pharyngeal Cancer Branch, National Institute of Dental Research, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892 4330, USA
    Mol Cell Biol 23:7030-43. 2003
    ..Furthermore, we provide evidence that the ERK-dependent activation of c-Fos is an integral component of the mitogenic pathway by which PDGF regulates normal and aberrant cell growth...
  20. ncbi Anatomical markers of activity in neuroendocrine systems: are we all 'fos-ed out'?
    G E Hoffman
    Department of Anatomy and Neurobiology, Program in Neuroscience, University of Maryland, School of Medicine, 685 W Baltimore Street, Baltimore, MD 21201, USA
    J Neuroendocrinol 14:259-68. 2002
    ..Together, as we move into the 21st Century, the use of multiple approach to study activity within neuroendocrine systems will further our understanding of these important systems...
  21. ncbi Molecular basis of long-term plasticity underlying addiction
    E J Nestler
    Department of Psychiatry and Center for Basic Neuroscience, University of Texas Southwestern Medical Center, 5, 323 Harry Hines Boulevard, Dallas, Texas 75390 9070, USA
    Nat Rev Neurosci 2:119-28. 2001
    ....
  22. ncbi Phosphorylation of c-Fos by members of the p38 MAPK family. Role in the AP-1 response to UV light
    Tamara Tanos
    Laboratorio de Fisiologia y Biologia Molecular, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, IFIBYNE CONICET, 1428 Buenos Aires, Argentina
    J Biol Chem 280:18842-52. 2005
    ..Thus, these newly described pathways act concomitantly with the activation of c-Jun by JNK/MAPKs, thereby contributing to the complexity of AP1-driven gene transcription regulation...
  23. ncbi Molecular interpretation of ERK signal duration by immediate early gene products
    Leon O Murphy
    Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA
    Nat Cell Biol 4:556-64. 2002
    ..Together, our data identify a general mechanism by which cells can interpret differences in ERK activation kinetics...
  24. ncbi Peripheral administration of nesfatin-1 reduces food intake in mice: the leptin-independent mechanism
    H Shimizu
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Japan
    Endocrinology 150:662-71. 2009
    ..Our findings indicate that the midsegment of nesfatin-1 causes anorexia, possibly by activating POMC and CART neurons in the NTS via a leptin-independent mechanism after peripheral stimulation...
  25. ncbi Using c-fos as a neural marker of pain
    J A Harris
    School of Psychology, The University of New South Wales, Sydney, Australia
    Brain Res Bull 45:1-8. 1998
    ..The increasing use of c-fos to study nociception necessitates a critical review of the practice, identifying the shortcomings as well as the strengths of this tool...
  26. ncbi Distinct roles of Jun : Fos and Jun : ATF dimers in oncogenesis
    H van Dam
    Department of Molecular Cell Biology, Leiden University Medical Center, Sylvius Laboratories, PO Box 9503, 2300 RA Leiden, The Netherlands
    Oncogene 20:2453-64. 2001
    ..Further genetic studies with Jun dimerization mutants will be required to be precise and extend the specific roles of the Jun : Fos and Jun : ATF dimers during cancer progression in avian and mammalian systems...
  27. pmc Crocidolite asbestos and SV40 are cocarcinogens in human mesothelial cells and in causing mesothelioma in hamsters
    Barbara Kroczynska
    Thoracic Oncology Program, Cardinal Bernardin Cancer Center, Loyola University Chicago, Maywood, IL 60153, USA
    Proc Natl Acad Sci U S A 103:14128-33. 2006
    ..Our results indicate that mineral fibers and viruses can be cocarcinogens and suggest that lower amounts of asbestos may be sufficient to cause MM in individuals infected with SV40...
  28. ncbi Heat hyperalgesia after incision requires TRPV1 and is distinct from pure inflammatory pain
    Esther M Pogatzki-Zahn
    Department of Anesthesiology, Johns Hopkins University, Baltimore, MD, USA
    Pain 115:296-307. 2005
    ..Thus, TRPV1 is important for the generation of thermal hyperalgesia after incision. Our observations suggest that all experimental pain models may not be equally appropriate to guide the development of postoperative pain therapies...
  29. ncbi The rat ponto-medullary network responsible for paradoxical sleep onset and maintenance: a combined microinjection and functional neuroanatomical study
    Romuald Boissard
    CNRS FRE 2469, Institut Fédératif des Neurosciences de Lyon IFR 19, Universite Claude Bernard Lyon I, 8 avenue Rockefeller, 69373 Lyon Cedex 08, France
    Eur J Neurosci 16:1959-73. 2002
    ..Furthermore, they suggest that GABAergic disinhibition and glutamate excitation of these neurons might also play a crucial role in the onset of PS...
  30. ncbi Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-beta-induced transcription
    Y Zhang
    Department of Growth and Development, Program in Cell Biology, University of California at San Francisco, 94143 0640, USA
    Nature 394:909-13. 1998
    ..This mechanism of transcriptional activation by TGF-beta, through functional and physical interactions between Smad3-Smad4 and c-Jun-c-Fos, shows that Smad signalling and MAPK/JNK signalling converge at AP1-binding promoter sites...
  31. pmc c-Fos activated phospholipid synthesis is required for neurite elongation in differentiating PC12 cells
    Germán A Gil
    Centro de Investigaciones en Química Biológica de Córdoba Consejo Nacional de Investigaciones Científicas y Técnicas, Departamento de Quimica Biologica, Facultad de Ciencias Quimicas, Universidad Nacional de Cordoba, 5000 Cordoba, Argentina
    Mol Biol Cell 15:1881-94. 2004
    ..Because phospholipids are key membrane components, we hypothesize this latter phenomenon as crucial to support membrane genesis demands required for cell growth and neurite elongation...
  32. ncbi Close encounters of many kinds: Fos-Jun interactions that mediate transcription regulatory specificity
    Y Chinenov
    Howard Hughes Medical Institute, University of Michigan Medical School Ann Arbor, Michigan, MI 48109-0650, USA
    Oncogene 20:2438-52. 2001
    ..The gene-specific architecture of these complexes can mediate the selective control of transcriptional activity...
  33. ncbi Constitutive activation of nuclear factor kappaB p50/p65 and Fra-1 and JunD is essential for deregulated interleukin 6 expression in prostate cancer
    Luiz F Zerbini
    BIDMC Genomics Center and New England Baptist Bone and Joint Institute, Boston, Massachusetts 02115, USA
    Cancer Res 63:2206-15. 2003
    ....
  34. ncbi Long-term monitoring of circadian rhythms in c-fos gene expression from suprachiasmatic nucleus cultures
    M E Geusz
    NSF Center for Biological Timing, University of Virginia, Charlottesville 22903, USA
    Curr Biol 7:758-66. 1997
    ..Here, we have devised a method of continuously measuring c-fos expression...
  35. ncbi c-Fos expression in hypothalamic nuclei of food-entrained rats
    Manuel Angeles-Castellanos
    Departamento de Anatomia, Facultad de Medicina, Instituto de Fisiologia Celular, Universidad Nacional Autonoma de Mexico, Mexico City DF 04510, Mexico
    Am J Physiol Regul Integr Comp Physiol 286:R158-65. 2004
    ..We can suggest that the PeF and TM may be involved with the arousal state during food anticipation and the DMH and LH with the time-keeping mechanism of FEO or its output...
  36. ncbi Cholinergic and noncholinergic brainstem neurons expressing Fos after paradoxical (REM) sleep deprivation and recovery
    Laure Verret
    CNRS UMR 5167, Institut Fédératif des Neurosciences de Lyon IFR 19, Faculté de médecine RTH Laennec, 7, Rue Guillaume Paradin, 69372 Lyon Cedex 08, France
    Eur J Neurosci 21:2488-504. 2005
    ..Altogether, our results open a new avenue of research to identify the specific role of the populations of neurons revealed, their interrelations and their neurochemical identity...
  37. ncbi Effects of honokiol and magnolol on acute and inflammatory pain models in mice
    Yi Ruu Lin
    Institute of Medical Sciences, Tzu Chi University, Hualien, Taiwan
    Life Sci 81:1071-8. 2007
    ..These results demonstrate that honokiol and magnolol effectively alleviate the formalin-induced inflammatory pain without motor and cognitive side effects, suggesting their therapeutic potential in the treatment of inflammatory pain...
  38. pmc A role of melanin-concentrating hormone producing neurons in the central regulation of paradoxical sleep
    Laure Verret
    CNRS UMR5167, Institut Fédératif des Neurosciences de Lyon IFR 19, Universite Claude Bernard Lyon I, 7 rue Guillaume Paradin, 69372 Lyon Cedex 08, France
    BMC Neurosci 4:19. 2003
    ..Next, we compared the effect of MCH and NaCl intracerebroventricular (ICV) administrations on sleep stage quantities to further determine whether MCH neurons play an active role in PS regulation...
  39. pmc c-Fos as a proapoptotic agent in TRAIL-induced apoptosis in prostate cancer cells
    Xiaoping Zhang
    Department of Urology, Massachusetts General Hospital, Boston, MA 02114, USA
    Cancer Res 67:9425-34. 2007
    ..Strategies to activate c-Fos or inhibit c-FLIP(L) may potentiate TRAIL-based proapoptotic therapies...
  40. ncbi Localization of the neurons active during paradoxical (REM) sleep and projecting to the locus coeruleus noradrenergic neurons in the rat
    Laure Verret
    Centre National de la Recherche Scientifique, Unité Mixte de Recherche 5167, Institut Fédératif des Neurosciences de Lyon IFR19, Lyon F 69372, France
    J Comp Neurol 495:573-86. 2006
    ..Although all these populations of CTb/Fos double-labeled neurons could be GABAergic and tonically inhibit LC neurons during PS, our results indicate that neurons from the DPGi constitute the best candidate for this role...
  41. pmc The Fos-related antigen Fra-1 is an activator of bone matrix formation
    Robert Eferl
    Research Institute of Molecular Pathology IMP, Vienna, Austria
    EMBO J 23:2789-99. 2004
    ..These results uncover a novel function of Fra-1 in regulating bone mass through bone matrix production by osteoblasts and chondrocytes...
  42. ncbi DNA binding activities of three murine Jun proteins: stimulation by Fos
    Y Nakabeppu
    Howard Hughes Medical Institute Laboratory, Baltimore, Maryland
    Cell 55:907-15. 1988
    ..If there are functional differences between them, they are likely to involve other activities of the Jun proteins...
  43. ncbi Rhabdomyosarcoma development in mice lacking Trp53 and Fos: tumor suppression by the Fos protooncogene
    Alexander Fleischmann
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Cancer Cell 4:477-82. 2003
    ..Moreover, Fos is able to repress Pax7 expression in rhabdomyosarcoma cell lines and primary myoblasts, suggesting a molecular link to genetic alterations involved in human rhabdomyosarcomas...
  44. ncbi CCK-8S activates c-Fos in a dose-dependent manner in nesfatin-1 immunoreactive neurons in the paraventricular nucleus of the hypothalamus and in the nucleus of the solitary tract of the brainstem
    Steffen Noetzel
    Department of Medicine, Division Hepatology, Gastroenterology, and Endocrinology Charité, Campus Virchow Universitätsmedizin Berlin, Germany
    Regul Pept 157:84-91. 2009
    ..No effect on the number of c-Fos-ir neurons was observed in the ARC. These results suggest that the effects of CCK on the HPA axis and on food intake may, at least in part, be mediated by nesfatin-1-ir neurons in the PVN...
  45. ncbi Patterns of brain activity associated with variation in voluntary wheel-running behavior
    Justin S Rhodes
    Department of Zoology, University of Wisconsin Madison, 53706, USA
    Behav Neurosci 117:1243-56. 2003
    ..Results implicate specific brain regions in motivation to run and others in control of the intensity of the locomotor behavior itself...
  46. ncbi Comparison of c-fos-like immunoreactivity in the brainstem following intraoral and intragastric infusions of chemical solutions in rats
    T Yamamoto
    Department of Behavioral Physiology, Faculty of Human Sciences, Osaka University, 1 2 Yamadaoka, Suita, 565 0871, Osaka, Japan
    Brain Res 866:144-51. 2000
    ..These results indicate that c-fos induction in brainstem neurons during ingestion reflects gustatory inputs and postingestional factors depending on the kind of food ingested...
  47. ncbi Regulation of DeltaFosB stability by phosphorylation
    Paula G Ulery
    Department of Psychiatry, Center for Basic Neuroscience, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9070, USA
    J Neurosci 26:5131-42. 2006
    ..These findings constitute the first evidence that DeltaFosB is phosphorylated and demonstrate that phosphorylation contributes to its stability, which is at the core of its ability to mediate long-lasting adaptations in brain...
  48. ncbi A role for glucagon-like peptide-1 in the central regulation of feeding
    M D Turton
    Department of Medicine, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK
    Nature 379:69-72. 1996
    ..Both of these regions of the brain are of primary importance in the regulation of feeding. These findings suggest that central GLP-1 is a new physiological mediator of satiety...
  49. ncbi The structural determinants responsible for c-Fos protein proteasomal degradation differ according to the conditions of expression
    Patrizia Ferrara
    Institut de Genetique Moleculaire, Montpellier Cedex, France
    Oncogene 22:1461-74. 2003
    ..Moreover, they also indicate that the half-life of c-Fos during the G0/G1 phase transition is determined by a delicate balance between opposing stabilizing and destabilizing mechanisms operating at the same time...
  50. ncbi DeltaFosB: a molecular switch for long-term adaptation in the brain
    Colleen A McClung
    Department of Psychiatry and Center for Basic Neuroscience, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9070, USA
    Brain Res Mol Brain Res 132:146-54. 2004
    ....
  51. pmc C-Fos elimination compensates for disabled-2 requirement in mouse extraembryonic endoderm development
    Dong Hua Yang
    Ovarian Cancer Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA
    Dev Dyn 238:514-23. 2009
    ....
  52. pmc The nucleosomal response associated with immediate-early gene induction is mediated via alternative MAP kinase cascades: MSK1 as a potential histone H3/HMG-14 kinase
    S Thomson
    Nuclear Signalling Laboratory, The Randall Institute, King s College, London, WC2B 5RL, UK
    EMBO J 18:4779-93. 1999
    ..Thus, the nucleosomal response is an invariable consequence of ERK and p38 but not JNK/SAPK activation, and MSK1 potentially provides a link to complete the circuit between cell surface and nucleosome...
  53. ncbi ERK-MAPK signaling coordinately regulates activity of Rac1 and RhoA for tumor cell motility
    Emmanuel Vial
    Cancer Research UK Centre for Cell and Molecular Biology, Institute of Cancer Research, 237 Fulham Road, London, SW3 6JB, United Kingdom
    Cancer Cell 4:67-79. 2003
    ....
  54. ncbi Crystal structure of the heterodimeric bZIP transcription factor c-Fos-c-Jun bound to DNA
    J N Glover
    Howard Hughes Medical Institute, Harvard University, Cambridge, Massachusetts 02138
    Nature 373:257-61. 1995
    ..There is an extensive network of electrostatic interactions between subunits within the coiled-coil, consistent with proposals that these interactions determine preferential formation of the heterodimer over either of the homodimers...
  55. ncbi Null mutation of c-fos impairs structural and functional plasticities in the kindling model of epilepsy
    Y Watanabe
    Department of Medicine Neurology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Neurosci 16:3827-36. 1996
    ..We favor the hypothesis that this "fos-less phenotype" is attributable to impaired seizure-induced transcriptional activation of one or more growth-related genes...
  56. pmc A growth factor-induced kinase phosphorylates the serum response factor at a site that regulates its DNA-binding activity
    V M Rivera
    Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts 02115
    Mol Cell Biol 13:6260-73. 1993
    ....
  57. ncbi Activation of capsaicin receptors on the sciatic nerve induces FOS expression in the spinal dorsal horn of adult rats
    Yu Peng Feng
    Department of Anatomy and K K Leung Brain Research Centre, The Fourth Military Medical University, Xi an, People s Republic of China
    Neurosignals 11:151-7. 2002
    ....
  58. ncbi The transcription factor Fos: a Janus-type regulator in health and disease
    Moritz Durchdewald
    German Cancer Research Center DKFZ, DKFZ ZMBH Alliance, Division of Signal Transduction and Growth Control, Heidelberg, Germany
    Histol Histopathol 24:1451-61. 2009
    ..Finally, selective inhibition of its function with a small molecule inhibitor in a preclinical mouse model of arthritis demonstrated that targeting Fos/AP-1 activity could be an auspicious new option for clinical use...
  59. ncbi CART in the dorsal vagal complex: sources of immunoreactivity and effects on Fos expression and food intake
    Huiyuan Zheng
    Neurobiology of Nutrition Laboratory, Pennington Biomedical Research Center, Louisiana State University, 6400 Perkins Road, Baton Rouge, LA 70808, USA
    Brain Res 957:298-310. 2002
    ..The functional role of CART in vagal afferents and the site of food intake suppression by 4th ventricular CARTp remain to be determined...
  60. pmc Yeast zymosan, a stimulus for TLR2 and dectin-1, induces regulatory antigen-presenting cells and immunological tolerance
    Stephanie Dillon
    Emory Vaccine Research Center and Department of Pathology, Emory University, Atlanta, Georgia 30329, USA
    J Clin Invest 116:916-28. 2006
    ..These data suggest several targets for pharmacological modulation of immune responses in various clinical settings...
  61. ncbi Disassociation of MAPK activation and c-Fos expression in F9 embryonic carcinoma cells following retinoic acid-induced endoderm differentiation
    E R Smith
    Ovarian Cancer Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    J Biol Chem 276:32094-100. 2001
    ....
  62. pmc Activation of c-fos in GABAergic neurones in the preoptic area during sleep and in response to sleep deprivation
    Hui Gong
    Department of Psychology, School of Medicine, University of California, Los Angeles, CA, USA
    J Physiol 556:935-46. 2004
    ..They also demonstrate that sleep deprivation is associated with increased activation of GABAergic neurones in the MnPN and vlPOA...
  63. pmc Infralimbic cortex activation increases c-Fos expression in intercalated neurons of the amygdala
    S Berretta
    Translational Neuroscience Laboratory, McLean Hospital, Belmont, MA 02478, USA
    Neuroscience 132:943-53. 2005
    ..Thus, our findings raise the possibility that the infralimbic cortex inhibits conditioned fear via the excitation of intercalated cells and the consequent inhibition of central amygdala neurons...
  64. ncbi Disabled-2 exerts its tumor suppressor activity by uncoupling c-Fos expression and MAP kinase activation
    J He
    Ovarian Cancer Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    J Biol Chem 276:26814-8. 2001
    ..Because Dab2 is frequently lost in cancer, the uncoupling of MAPK activation and c-Fos expression may be a favored target for inactivation in tumorigenicity...
  65. ncbi Gene expression profiling in prostate cancer cells with Akt activation reveals Fra-1 as an Akt-inducible gene
    Gunjan Tiwari
    Department of Molecular Pharmacology, Stanford University and Department of Pathology, Stanford University School of Medicine, Stanford, CA
    Mol Cancer Res 1:475-84. 2003
    ..Moreover, the identification of Fra-1 as an Akt-regulated gene may have implications for the ability of Akt to transform cells since Fra-1 has been implicated in cell growth and the aggressiveness of tumors...
  66. ncbi Signaling pathways leading to transcription and translation cooperatively regulate the transient increase in expression of c-Fos protein
    K Takeuchi
    Department of Biochemistry, Faculty of Pharmaceutical Sciences, Setsunan University, Hirakata, Osaka 573-0101, Japan
    J Biol Chem 276:26077-83. 2001
    ..Regulation of the translation process of c-fos mRNA in addition to the immediate activation of c-fos transcription is necessary for the transient increase in the level of c-Fos protein to stimulate cell proliferation...
  67. ncbi Cutting edge: different Toll-like receptor agonists instruct dendritic cells to induce distinct Th responses via differential modulation of extracellular signal-regulated kinase-mitogen-activated protein kinase and c-Fos
    Sudhanshu Agrawal
    Emory Vaccine Center, Atlanta, GA 30329, USA
    J Immunol 171:4984-9. 2003
    ..Thus, distinct TLR agonists differentially modulate extracellular signal-regulated kinase signaling, c-Fos activity, and cytokine responses in DCs to stimulate different Th responses...
  68. pmc Differential induction of nuclear factor-kappaB and activator protein-1 activity after CD40 ligation is associated with primary human hepatocyte apoptosis or intrahepatic endothelial cell proliferation
    Jalal Ahmed-Choudhury
    Liver Research Laboratories, Medical Research Council Centre for Immune Regulation, University of Birmingham Institute of Clinical Science, Queen Elizabeth Hospital, Edgbaston, Birmingham, B15 2TH, United Kingdom
    Mol Biol Cell 14:1334-45. 2003
    ..Transient activation of NF-kappaB and sustained AP-1 activation is associated with apoptosis in hepatocytes, whereas prolonged NF-kappaB activation and a lack of AP-1 activation in IHECs result in proliferation...
  69. ncbi Activator protein 1 DNA binding activity is decreased in lesional psoriatic skin compared with nonlesional psoriatic skin
    C Johansen
    Department of Dermatology, Marselisborg Hospital, University of Aarhus, P P Orumsgade 11, DK 8000 Aarhus C, Denmark
    Br J Dermatol 151:600-7. 2004
    ..The transcription factor activator protein 1 (AP-1) is known to play an important role in cell proliferation and differentiation...
  70. ncbi Task-dependent and cell-type-specific Fos enhancement in rat sensory cortices during audio-visual discrimination
    Shuzo Sakata
    Speciation Mechanisms I, National Institute for Basic Biology, Okazaki 444 8585, Japan
    Eur J Neurosci 15:735-43. 2002
    ..These results suggest that modulation in cortical excitatory neurons might have critical roles in selecting and processing behaviourally relevant sensory stimuli...
  71. ncbi Blockade of central GLP-1 receptors prevents CART-induced hypophagia and brain c-Fos expression
    Susan Aja
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 720 Rutland Avenue, Ross 618, Baltimore, MD 21205, USA
    Peptides 27:157-64. 2006
    ..These data suggest that i.c.v. CART administration activates a central release of GLP-1 to inhibit feeding and produce widespread neural activation...
  72. ncbi A recombinant human glucagon-like peptide (GLP)-1-albumin protein (albugon) mimics peptidergic activation of GLP-1 receptor-dependent pathways coupled with satiety, gastrointestinal motility, and glucose homeostasis
    Laurie L Baggio
    Toronto General Hospital, Banting and Best Diabetes Centre, 200 Elizabeth St, MBRW4R 402, Toronto, Canada
    Diabetes 53:2492-500. 2004
    ..These findings illustrate that peripheral administration of a larger peptide-albumin recombinant protein mimics GLP-1R-dependent activation of central and peripheral pathways regulating energy intake and glucose homeostasis in vivo...
  73. ncbi Induction of c-Fos expression in specific areas of the fear circuitry in rat forebrain by anxiogenic drugs
    Nicolas Singewald
    Department of Pharmacology and Toxicology, University of Innsbruck, Innsbruck, Austria
    Biol Psychiatry 53:275-83. 2003
    ..The fact that induction of anxiety- and panic-related symptoms is a property common to a range of drugs suggests that common neural substrates underlie their behavioral effects...
  74. ncbi Fra-1 expression in malignant and benign thyroid tumor
    Y H Kim
    Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea
    Korean J Intern Med 16:93-7. 2001
    ....
  75. ncbi Identification of a C-terminal tripeptide motif involved in the control of rapid proteasomal degradation of c-Fos proto-oncoprotein during the G(0)-to-S phase transition
    C Acquaviva
    Institute of Molecular Genetics, UMR5535/IFR24, CNRS, 1919, route de Mende, 34293-Montpellier Cedex 05, France
    Oncogene 20:7563-72. 2001
    ..We, however, showed that the PTL motif does not exert its effect by counteracting a stabilizing effect of these phosphorylations under our experimental conditions...
  76. pmc Autoamplification of NFATc1 expression determines its essential role in bone homeostasis
    Masataka Asagiri
    Department of Cell Signaling, Tokyo Medical and Dental University, Japan
    J Exp Med 202:1261-9. 2005
    ..Thus, this study establishes that NFATc1 represents a potential therapeutic target for bone disease and reveals a mechanism that underlies the essential role of NFATc1 in bone homeostasis...
  77. pmc Regulation of fosB and DeltafosB mRNA expression: in vivo and in vitro studies
    Imran N Alibhai
    Department of Psychiatry and Center for Basic Neuroscience, The University of Texas Southwestern Medical Center, Dallas, TX 75390 9070, USA
    Brain Res 1143:22-33. 2007
    ....
  78. pmc Neoplastic transformation of rat thyroid cells requires the junB and fra-1 gene induction which is dependent on the HMGI-C gene product
    D Vallone
    Istituto Internazionale di Genetica e Biofisica, CNR, Via Guglielmo Marconi 12, I 80125 Naples, Italy
    EMBO J 16:5310-21. 1997
    ....
  79. ncbi DEP-induced fra-1 expression correlates with a distinct activation of AP-1-dependent gene transcription in the lung
    Qin Zhang
    The Johns Hopkins University, Department of Environmental Health Sciences, Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Am J Physiol Lung Cell Mol Physiol 286:L427-36. 2004
    ..Collectively, these findings suggest that fra-1 induction by DEP may play a role in selectively regulating gene expression involved in alveolar epithelial cell injury and repair...
  80. pmc Overexpression of Fos-related antigen-1 in head and neck squamous cell carcinoma
    Flavia R R Mangone
    Faculdade de Medicina da Universidade de Sao Paulo, Departamento de Radiologia, Disciplina de Oncologia, 01246 903 Sao Paulo, Brazil
    Int J Exp Pathol 86:205-12. 2005
    ..0005). Thus, Fra-1 gene induction and accumulation of Fra-1 protein may contribute to the neoplastic phenotype in HNSCC...
  81. ncbi The ability of Fos family members to produce phenotypic changes in epithelioid cells is not directly linked to their transactivation potentials
    Henriette Andersen
    Danish Cancer Society, Department of Molecular Cancer Biology, Strandboulevarden 49, DK 2100, Copenhagen Ø, Denmark
    Oncogene 21:4843-8. 2002
    ..We therefore conclude that c-Fos, Fra-1 and Fra-2 differently activate transcription of target genes and induce morphological changes in epithelioid carcinoma cells in a manner not directly linked to their transactivation potentials...
  82. pmc NF-kappaB and AP-1 connection: mechanism of NF-kappaB-dependent regulation of AP-1 activity
    Shuichi Fujioka
    Department of Surgical Oncology, Box 107, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Mol Cell Biol 24:7806-19. 2004
    ..Thus, our study revealed a distinct and essential role of NF-kappaB in participating in the regulation of elk-1, c-fos, and VEGF expression...
  83. pmc Glucagon-like peptide-1 receptor stimulation increases blood pressure and heart rate and activates autonomic regulatory neurons
    Hiroshi Yamamoto
    Department of Medicine and Division of Endocrinology, Beth Israel Deaconess Medical Center, Harvard Medical School, 99 Brookline Avenue, Boston, MA 02215, USA
    J Clin Invest 110:43-52. 2002
    ..These findings suggest that the central GLP-1 system represents a regulator of sympathetic outflow leading to downstream activation of cardiovascular responses in vivo...
  84. ncbi A mechanism for translationally coupled mRNA turnover: interaction between the poly(A) tail and a c-fos RNA coding determinant via a protein complex
    C Grosset
    Department of Biochemistry and Molecular Biology, The University of Texas Houston Medical School 77030, USA
    Cell 103:29-40. 2000
    ..We propose that a bridging complex forms between the poly(A) tail and the mCRD and ribosome transit disrupts or reorganizes the complex, leading to rapid RNA deadenylation and decay...
  85. ncbi Fos, nociception and the dorsal horn
    Richard E Coggeshall
    Neuroscience and Cell Biology, The University of Texas Medical Branch, Galveston, TX 77555 1069, USA
    Prog Neurobiol 77:299-352. 2005
    ..Thus, the purpose of this review is to summarize the studies whose numbers are geometrically expanding that deal with Fos in the dorsal horn and the conclusions therefrom...
  86. ncbi The forced swimming-induced behavioural immobility response involves histone H3 phospho-acetylation and c-Fos induction in dentate gyrus granule neurons via activation of the N-methyl-D-aspartate/extracellular signal-regulated kinase/mitogen- and stress-a
    Yalini Chandramohan
    Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, Dorothy Hodgkin Building, University of Bristol, Whitson Street, Bristol BS1 3NY, UK
    Eur J Neurosci 27:2701-13. 2008
    ..We conclude that the forced swimming-induced behavioural immobility response requires histone H3 phospho-acetylation and c-Fos induction in distinct dentate granule neurons through recruitment of the NMDA/ERK/MSK 1/2 pathway...
  87. ncbi AP-1 in mouse development and tumorigenesis
    W Jochum
    Research Institute of Molecular Pathology (I.M.P, Dr. Bohr-Gasse 7, A-1030 Vienna, Austria
    Oncogene 20:2401-12. 2001
    ....
  88. ncbi c-Fos transcriptional activity stimulated by H-Ras-activated protein kinase distinct from JNK and ERK
    T Deng
    Department of Pharmacology, University of California at San Diego School of Medicine, La Jolla 92093 0636
    Nature 371:171-5. 1994
    ..Therefore, at least three types of proline-directed kinases transmit Ras- and mitogen-generated signals to the transcriptional machinery...
  89. ncbi Jun signalling in the epidermis: From developmental defects to psoriasis and skin tumors
    Rainer Zenz
    Research Institute of Molecular Pathology I M P, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Int J Biochem Cell Biol 38:1043-9. 2006
    ....
  90. ncbi Fos/AP-1 proteins in bone and the immune system
    Erwin F Wagner
    Research Institute of Molecular Pathology IMP, Vienna, Austria
    Immunol Rev 208:126-40. 2005
    ..We also attempt to put potential therapeutic strategies for inflammatory bone diseases in perspective...
  91. ncbi Essential role of the fosB gene in molecular, cellular, and behavioral actions of chronic electroconvulsive seizures
    N Hiroi
    Laboratory of Molecular Psychiatry, Departments of Psychiatry and Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06508, USA
    J Neurosci 18:6952-62. 1998
    ..These findings identify fosB gene products as transcription factors critical for molecular, electrophysiological, and behavioral adaptations to motor seizures...
  92. ncbi Molecular basis for the recognition of phosphorylated and phosphoacetylated histone h3 by 14-3-3
    Neil MacDonald
    Syngenta Central Toxicology Laboratory, Alderley Park, Macclesfield, SK10 4TJ, United Kingdom
    Mol Cell 20:199-211. 2005
    ..14-3-3 isoforms thus represent a class of proteins that mediate the effect of histone phosphorylation at inducible genes...
  93. ncbi Superficial NK1-expressing neurons control spinal excitability through activation of descending pathways
    Rie Suzuki
    Department of Pharmacology, University College London, Gower Street, London WC1E 6BT, UK
    Nat Neurosci 5:1319-26. 2002
    ....
  94. ncbi Resistance to extinction is associated with impaired immediate early gene induction in medial prefrontal cortex and amygdala
    Cyril Herry
    Laboratoire de Neurosciences Cognitives, CNRS UMR 5106, Universite de Bordeaux I, Avenue des Facultes, 33405 Talence, France
    Eur J Neurosci 20:781-90. 2004
    ..This suggests that coordinated activity-dependent changes in gene expression in the mPFC and the amygdala may underlie the formation of long-term fear extinction memory...
  95. ncbi Protein kinase A and AP-1 (c-Fos/JunD) are induced during apoptosis of mouse mammary epithelial cells
    A Marti
    Laboratory for Clinical and Experimental Research, University of Bern, Switzerland
    Oncogene 9:1213-23. 1994
    ..A similar induction of AP-1 (cFos/JunD) was also observed in the involuting rat ventral prostate pointing to a possible role for AP-1 in programmed cell death...
  96. ncbi Neurobiological correlates of high (HAB) versus low anxiety-related behavior (LAB): differential Fos expression in HAB and LAB rats
    Nicolas Salome
    Laboratoire de Stress Périnatal, Universite de Lille 1, Villeneuve d Ascq, France
    Biol Psychiatry 55:715-23. 2004
    ..Two Wistar rat lines selectively bred for either high (HAB) or low (LAB) anxiety-related behavior were used to identify neurobiological correlates of trait anxiety...
  97. pmc Cell transformation by c-fos requires an extended period of expression and is independent of the cell cycle
    G G Miao
    Roche Institute of Molecular Biology, Nutley, New Jersey 07110
    Mol Cell Biol 14:4295-310. 1994
    ..Our results suggest that cell transformation by Fos requires increased expression of a target gene(s) with a long-lived product(s) that must reach a critical level...
  98. pmc Urocortin II: a member of the corticotropin-releasing factor (CRF) neuropeptide family that is selectively bound by type 2 CRF receptors
    T M Reyes
    Laboratory of Neuronal Structure and Function, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 98:2843-8. 2001
    ..Initial functional studies are consistent with Ucn II involvement in central autonomic and appetitive control, but not in generalized behavioral activation...
  99. pmc Intraretinal signaling by ganglion cell photoreceptors to dopaminergic amacrine neurons
    Dao Qi Zhang
    Department of Biological Sciences, Vanderbilt University, Nashville, TN 37235, USA
    Proc Natl Acad Sci U S A 105:14181-6. 2008
    ..This unprecedented centrifugal outflow of ganglion-cell signals within the retina provides a novel basis for the restructuring of retinal circuits by light...
  100. pmc The transcription activation domains of Fos and Jun induce DNA bending through electrostatic interactions
    T K Kerppola
    Howard Hughes Medical Institute and Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor 48109 0650, USA
    EMBO J 16:2907-16. 1997
    ..Consequently, regions outside the minimal DNA-binding domain can influence DNA structure, and may thereby contribute to the architectural reorganization of the promoter region required for gene activation...
  101. pmc Impaired extinction of learned fear in rats selectively bred for high anxiety--evidence of altered neuronal processing in prefrontal-amygdala pathways
    Patrik Muigg
    Department of Pharmacology and Toxicology, Institute of Pharmacy, Center for Molecular Biosciences Innsbruck, University of Innsbruck, Peter Mayer Strasse 1, A 6020 Innsbruck, Austria
    Eur J Neurosci 28:2299-309. 2008
    ..Thus, HAB rats may represent a clinically relevant model to study the mechanisms and potential targets to accelerate delayed extinction processes in subjects with enhanced trait anxiety...

Research Grants71

  1. Research Initiative for Scientific Enhancement 2009-2013
    PAUL T BUONORA; Fiscal Year: 2012
    ..abstract_text> ..
  2. ONTOGENY OF NEUROADAPTIVE RESPONSES TO PSYCHOSTIMULANTS
    Michelle Ehrlich; Fiscal Year: 2002
    ..abstract_text> ..
  3. Morphine-induced chronic Fra upregulation
    DANIELLA LANCELLOTTI; Fiscal Year: 2004
    ..abstract_text> ..
  4. Social Stress and Sensorimotor Gating Deficits in Rats
    RONALD HAMMER; Fiscal Year: 2006
    ....
  5. BASAL GANGLIA CIRCUITRY IMMEDIATE EARLY GENE EXPRESSION
    David Wirtshafter; Fiscal Year: 2003
    ..Other studies will examine the effects of lesions within the basal ganglia on the IEG expression induced by systemic administration of dopaminergic drugs. ..
  6. Lateral Hypothalamus, Dopamine and Ingestive Behavior
    David Wirtshafter; Fiscal Year: 2007
    ..Gaining an understanding of these systems is a prerequisite for the rational development of novel treatments for disturbances of ingestion, such as occur in obesity, bulemia and cahchexia. [unreadable] [unreadable] [unreadable]..
  7. Cue dependency with intravenous nutrients and nicotine
    Neil Rowland; Fiscal Year: 2007
    ..These studies may help to develop ways in conditioned preferences can be manipulated to prevent or treat certain addictive disorders, including overeating. [unreadable] [unreadable] [unreadable]..
  8. Molecular Basis of D1 and D2 Priming
    Alexia Pollack; Fiscal Year: 2003
    ..Elucidation of this mechanism could lead to treatment strategies aimed to prevent these dyskinesias, which would, in turn, lengthen the time that dopamine replacement therapy is effective to treat patients with PD. ..
  9. Role of Fra-1 in Mesothelioma
    Maria Ramos Nino; Fiscal Year: 2008
    ..The long-term goal of this research plan is to understand the molecular mechanisms governing mesothelial cell tumorigenesis. ..
  10. Physiology and genetics of food procurement in rodents
    Neil Rowland; Fiscal Year: 2008
    ..The proposed studies will be the first to address the issue of behavioral change induced by anorectics under such conditions of simulated economic costs. [unreadable] [unreadable] [unreadable]..
  11. NEURAL AND GI SUBSTRATES IN BOMBESIN SATIETY
    ELLEN LADENHEIM; Fiscal Year: 2006
    ..Such an understanding will significantly enhance our understanding of the mechanisms underlying overall energy regulation and may lead to novel treatments for obesity or eating disorders ..
  12. Hindbrain mechanisms of hypoglycemia unawarness
    Sue Ritter; Fiscal Year: 2005
    ..Corticosterone infusions and specific stressors with differing effects on corticosterone secretion will be examined for their ability to induce HAAF. ..
  13. CNS Estrogen Receptors and Social Behavior
    BRUCE CUSHING; Fiscal Year: 2004
    ....
  14. Neural Analysis of Maternal Aggression
    STEPHEN GAMMIE; Fiscal Year: 2006
    ..Basic research into sex differences in aggression, then, is important to understanding the biological underpinnings of sex and gender differences in social behavior, health, and disease. ..
  15. HORMONES AND BEHAVIORAL DEVELOPMENT
    BRUCE CUSHING; Fiscal Year: 2004
    ....
  16. Prenatal Corticosteroid Impact on Hippocampus
    LIBOR VELISEK; Fiscal Year: 2004
    ..The data of this proposal will be critical for determining long-term adverse effects of multiple course prenatal corticosteroid therapy and for the ameliorating these effects in the offspring. ..
  17. Does Nasal Stimulation Activate Presympathetic Neurons?
    Paul McCulloch; Fiscal Year: 2005
    ..As such, this research has implications for understanding the etiology of neurogenic hypertension. ..
  18. Neural basis of learned food aversion and nausea
    CHARLES HORN; Fiscal Year: 2009
    ..Effective treatment of nausea may substantially improve the quality of life for patients with chronic disease. ..
  19. ELEMENTARY SCHOOL NEUROSCIENCE LITERACY
    Gary Duncan; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  20. Antipsychotic Actions in Models of NMDA Hypofunction
    Gary Duncan; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  21. The Status and Future of Acupuncture Research: 10 Years Post-NIH Consensus Confer
    Lixing Lao; Fiscal Year: 2007
    ..The proposed conference will do so. [unreadable] [unreadable] [unreadable] [unreadable]..
  22. CENTRAL CONTROL OF OXYTOCIN RELEASE DURING GESTATION
    STEVEN BEALER; Fiscal Year: 2008
    ..abstract_text> ..
  23. Hindbrain Mechanisms of Hypoglycemia Unawareness
    W Ritter; Fiscal Year: 2007
    ..abstract_text> ..
  24. Fra-1: A new target for a genomic breast cancer vaccine
    Ralph Reisfeld; Fiscal Year: 2009
    ..This allows for this vaccine to go full circle in evaluation from bench to bedside and back for further improvement. ..
  25. Neurocircuitry of Illness Induced Behavioral Depression
    LISA GOEHLER; Fiscal Year: 2009
    ....
  26. Muller glia and neuronal regeneration in the retina
    Andy Fischer; Fiscal Year: 2009
    ..This information could be applied to not only stimulate neural regeneration to treat sight-threatening diseases of the retina, but also to control gliosis that may be detrimental to the pathogenesis of retinal disorders. ..
  27. COCAINE REGULATION OF FOSB SPLICING
    Judith Potashkin; Fiscal Year: 2004
    ..Because dFosB is also induced by chronic administration of other drugs of abuse, such as amphetamine, nicotine and opiates, the results obtained in this study may also lead to a better understanding of drug addiction. ..
  28. CNS AND SALT APPETITE
    DOUGLAS FITTS; Fiscal Year: 2004
    ..The results will have implications for the central control of blood pressure and endocrine secretions as well as behavior during various challenges to body hydration. ..
  29. NOVEL STRATEGIES FOR THE IMMUNOTHERAPY OF COLON CANCER
    Ralph Reisfeld; Fiscal Year: 2003
    ..The achievement of this proposal's objectives should lead to the design of effective DNA vaccines based on rational immunological principles that may ultimately lead to the improved treatment of colon cancer. ..
  30. Neural and Immune Cell Interactions: Two of a Kind
    LISA GOEHLER; Fiscal Year: 2002
    ..Finally, the interactions between immune and neural cells may well be bi-directional, providing a novel mechanism by which neural activity can modulate immune cell functions. ..
  31. MECHANISMS OF PRENATAL COCAINE AND ETHANOL TOXICITY
    Ellen Mitchell; Fiscal Year: 2003
    ..In addition, we will assess exposed pups for susceptibility to further hypoxia at birth and monitor physiological differences after they reach adulthood. ..
  32. NEURAL SYSTEMS REGULATING VASOPRESSIN RELEASE
    J Cunningham; Fiscal Year: 2002
    ..These experiments will determine critical components of the pathways that allow the cardiovascular system to regulate the central nervous system. ..
  33. CONTROL OF FEEDING BEHAVIOR--HEPATIC AFFERENT SIGNALING
    CHARLES HORN; Fiscal Year: 2002
    ..Results from this project may contribute to a better understanding of metabolic stimuli that are sensed by the nervous system, and may elucidate neural controls that are involved in obesity, anorexia, and diabetes. ..
  34. The Delayed Effects of Phencyclidine: Mechanisms
    Sarah Turgeon; Fiscal Year: 2002
    ..These experiments will begin to identify the mechanisms by which PCP produces schizophrenia-like behaviors in animals, providing insight into potential pathophysiologies underlying schizophrenia in humans. ..
  35. SEXUAL DIMORPHISM IN SEIZURE CONTROL
    JANA VELISKOVA; Fiscal Year: 2002
    ..Rats of both sexes and various ages will be used. These studies may lead to the development of new antiepileptic treatments that take into the account sexual age-related differences. ..
  36. Altered Baroreflex Responses by Dietary Sodium
    STEVEN BEALER; Fiscal Year: 2003
    ..The work will be performed in the Department of Physiology, University of Tennessee, Memphis, TN 38163. ..
  37. Gordon Research Conference on the Chemical Senses
    Susan Travers; Fiscal Year: 2003
    ..The goal of the 2003 Gordon Conference on the Chemical Senses is to vigorously discuss those new, sometimes controversial ideas and to stimulate further, yet more novel hypotheses. ..
  38. Trigeminal Autonomic Interactions
    Paul McCulloch; Fiscal Year: 2002
    ..Having a better understanding of brainstem cardiorespiratory integration might provide a neurological basis for the etiology of SIDS. ..
  39. The Psychobiology of Rhythms in Diurnal Mammals
    Laura Smale; Fiscal Year: 2009
    ..These insights will help us understand and eventually alleviate the myriad medical and behavioral problems faced by shift workers, who represent 16% of Americans ..
  40. Anatomy and Activation of Nucleus Accumbens CART Neurons
    GEORGE HUBERT; Fiscal Year: 2008
    ..This will add to our understanding of the anatomy of drug abuse and to hypothesize treatments to alleviate this major social problem. ..
  41. Craniofacial Imaging in the 21st Century
    Sunil Kapila; Fiscal Year: 2002
    ..The meeting will be limited to 300 participants who have a background in imaging. This symposia series will provide momentum to discoveries that will be important to craniofacial sciences and patient care. ..
  42. Studying coordinated firing in hypothalamic GnRH neurons
    KELLY SUTER; Fiscal Year: 2007
    ..This will allow us to determine whether desynchronization of firing is a viable mechanism for changes in GnRH secretion during normal reproduction and in reproductive pathologies. [unreadable] [unreadable]..
  43. OVARIAN HORMONAL CONTROL OF MEAL SIZE
    NORCROSS GEARY; Fiscal Year: 2008
    ..8) Determine the tonic and phasic effects of estradiol on glutamate synaptogenesis in the brainstem by using immunocytochemical detection of synaptic proteins. [unreadable] [unreadable]..
  44. NEURAL BASIS OF TASTE ELICITED INGESTION AND REJECTION
    JOSEPH TRAVERS; Fiscal Year: 2009
    ..Understanding the neurological basis of the fundamental biological decision ingest or reject food will contribute to the eventual solution of these chronic debilitating disorders. ..
  45. The Regulatory Role of Spinal Lipoxins in Nociception
    Linda Sorkin; Fiscal Year: 2008
    ..The aim of this proposal is to investigate the role of lipoxins in conditions associated with persistent inflammatory pain. [unreadable] [unreadable] [unreadable]..
  46. HORMONAL REGULATION OF MAP KINASE VIA RAP1 AND B-RAF
    Philip J S Stork; Fiscal Year: 2010
    ..We will determine the biochemical basis for this specificity of Rap1 for B-Raf in Specific Aim 3. In this aim, we will also establish novel mouse models to test the hypothesis that B-Raf has irreplaceable functions in vivo. ..
  47. Controlling the Max Network
    Peter Vogt; Fiscal Year: 2008
    ..The proposed work on stabilizers in the Myc-Max network could open the door to a new way of influencing and directing cell growth. ..
  48. Molecular Requirements for Recombinant Cytotoxins Efficacy
    Waldemar Debinski; Fiscal Year: 2010
    ..It is expected that the new information gathered will be invaluable in further molecular design of recombinant anti-cancer cytotoxins. ..
  49. p27Kip1 and RPE Cell Cycle
    DENNIS DEFOE; Fiscal Year: 2003
    ..The alternative hypothesis that the thickening of the RPE layer is due to an increase in cell size will be examined by morphometric analysis of images obtained by confocal microscopy. ..
  50. Amygdalar and Thalamic Abnormalities in Schizophrenia
    Sabina Berretta; Fiscal Year: 2002
    ....
  51. Lower urinary tract dysfunction in Parkinson's disease
    Naoki Yoshimura; Fiscal Year: 2003
    ..This is a high priority in the urologic care of patients with Parkinson's disease. ..
  52. Axonal Targeting in the Mouse Olfactory Bulb
    Ernesto Salcedo; Fiscal Year: 2004
    ..We will also examine the effect that nerve transection has on gene expression. These experiments should significantly further our understanding of axonal targeting in the main olfactory bulb. ..
  53. HYPOTHALAMIC HYPOCRETIN PATHWAYS MODULATING FEEDING
    CATHERINE KOTZ; Fiscal Year: 2004
    ....
  54. Bladder Pain Gene Therapy with Pro-opiomelanocortin cDNA
    Naoki Yoshimura; Fiscal Year: 2004
    ..This research project is important to provide a solid basis for potential future clinical application. ..
  55. NF-KB SIGNAL TRANSDUCTION IN BRAIN INJURY
    KEITH PENNYPACKER; Fiscal Year: 2003
    ..These studies will define the role of NF-kB in the process of brain injury and subsequent repair and regeneration processes. ..
  56. Cellular and Molecular Mechanisms of REM Sleep Control
    James Quattrochi; Fiscal Year: 2005
    ....
  57. Molecular Determinants of Compulsive Cocaine-Taking
    Ming Xu; Fiscal Year: 2006
    ....
  58. Mechanism of Estrogen's Inhibitory Effects on Feeding
    LISA ECKEL; Fiscal Year: 2004
    ..Because eating disorders are more prevalent in women than in men, this proposal targets an important research question with clear clinical relevance . ..
  59. MODULATION OF NEUROENDOCRINE FUNCTION IN SEPSIS
    DREW CARLSON; Fiscal Year: 2005
    ..The mechanisms revealed are likely to play a significant role in the suppression of host defense and the onset of septic shock...
  60. THE ONCOGENICITY OF WINGED HELIX PROTEINS
    Peter Vogt; Fiscal Year: 2003
    ..The nature of activating mutations, the interactions with the preinitiation complex, and the identity and function of target genes will reveal novel molecular targets for therapeutic intervention. ..
  61. Development of viscerosensory neural inputs in rat brain
    Thomas Koehnle; Fiscal Year: 2006
    ..The experimental outcomes will significantly enhance our understanding of how these pathways mature, and how they operate in health and disease. [unreadable] [unreadable] [unreadable]..
  62. Prenatal ethanol, social behavior, and prefrontal cortex
    Derek Hamilton; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  63. Role of ASIC3 in the etiology of fibromyalgia
    Kathleen A Sluka; Fiscal Year: 2010
    ..These studies could lead to peripherally based therapeutic approaches to control pain without undesirable CMS (central nervous system) side effects, including gene therapy. ..
  64. ELECTROPHYSIOLOGY & PHARMACOLOGY OF SLEEP-WAKEFULNESS
    Mahesh Thakkar; Fiscal Year: 2004
    ..Preliminary data suggest a strong suppressive effect of microdialysis-applied 8-OH-DPAT on state-related discharge activity of the dorsal raphe nucleus, and we will also investigate the effects of 5HT1A antagonists. ..
  65. OLFACTORY CODING
    Burton Slotnick; Fiscal Year: 2003
    ..Behavior tasks will use precision olfactometry. Anterograde transport of horseradish peroxidase will be used to assess connections between the olfactory epithelium and olfactory bulb in experimental rats. ..
  66. OLFACTORY FUNCTION IN GENE-TARGETED MICE
    Burton Slotnick; Fiscal Year: 2002
    ..A final report of these studies will incorporate a detailed description of apparatus, methods protocol and files of raw data and summary statistics presented in database and spreadsheet format. ..
  67. Neurobiology of Joint Manipulation Induced Analgesia
    Kathleen Sluka; Fiscal Year: 2003
    ..This information will further assist the clinician in determining the treatment of choice for a particular patient and potentially guide future clinical research. ..
  68. 2005 Bones & Teeth Gordon Conference
    Rene St Arnaud; Fiscal Year: 2005
    ..These funds, if granted, will aid immeasurably in allowing the Gordon Research Conference to fulfill its function to stimulate further creativity in bone, cartilage and tooth research. ..
  69. NEUROBIOLOGY OF CHRONIC MUSCLE PAIN
    Kathleen Sluka; Fiscal Year: 2003
    ..These proposed studies will help in the understanding and thus potential treatment of chronic muscle pain, including such conditions as fibromyalgia, myofascial pain and low back pain. ..
  70. Retinal Neurons Afferent to the Circadian System
    GARY PICKARD; Fiscal Year: 2005
    ..Understanding the retinal neurons and circuits afferent to the SCN and IGL will aid in our ability to understand and treat these disturbances of phase. ..
  71. Fibronectin Fragment-Induced Osteolysis Mediated by MMPs
    Sunil Kapila; Fiscal Year: 2009
    ..These studies will provide a fundamental understanding of the basis for bone loss in periodontal disease and other osteolytic diseases. ..