Genomes and Genes
proto oncogene proteins c fos
Summary: Cellular DNA-binding proteins encoded by the c-fos genes (GENES, FOS). They are involved in growth-related transcriptional control. c-fos combines with c-jun (PROTO-ONCOGENE PROTEINS C-JUN) to form a c-fos/c-jun heterodimer (TRANSCRIPTION FACTOR AP-1) that binds to the TRE (TPA-responsive element) in promoters of certain genes.
Publications270 found, 100 shown here
- AP-1 subunits: quarrel and harmony among siblingsJochen Hess
Deutsches Krebsforschungszentrum, Division of Signal Transduction and Growth Control, 69120 Heidelberg, Germany
J Cell Sci 117:5965-73. 2004....
- c-Fos: a key regulator of osteoclast-macrophage lineage determination and bone remodelingA E Grigoriadis
Research Institute of Molecular Pathology IMP, Vienna, Austria
Science 266:443-8. 1994..These results identify Fos as a key regulator of osteoclast-macrophage lineage determination in vivo and provide insights into the molecular mechanisms underlying metabolic bone diseases...
- Nuclear factor of activated T-cells (NFAT) rescues osteoclastogenesis in precursors lacking c-FosKoichi Matsuo
Department of Microbiology and Immunology, School of Medicine, Keio University, Tokyo 160 8582, Japan
J Biol Chem 279:26475-80. 2004..These data indicate that lack of Nfatc1 expression is the cause of the differentiation block in Fos(-/-) osteoclast precursors and that transcriptional induction of Nfatc1 is a major function of c-Fos in osteoclast differentiation...
- AP-1: a double-edged sword in tumorigenesisRobert Eferl
Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030 Vienna, Austria
Nat Rev Cancer 3:859-68. 2003
- FRA-1 expression level regulates proliferation and invasiveness of breast cancer cellsKarine Belguise
INSERM U540, Endocrinologie Moléculaire et Cellulaire des Cancers, 60 rue de Navacelles, 34090 Montpellier, France
Oncogene 24:1434-44. 2005..These overall results show that high Fra-1 expression is associated with a more malignant cell phenotype and suggest that Fra-1 could have a pivotal role in breast cancer progression...
- Cross-family dimerization of transcription factors Fos/Jun and ATF/CREB alters DNA binding specificityT Hai
Department of Medical Biochemistry, Ohio State University, Columbus 43210
Proc Natl Acad Sci U S A 88:3720-4. 1991..These findings indicate that the Fos/Jun and ATF/CREB families of transcription factors are not as distinct as was previously thought. We suggest that they can be grouped into a superfamily of transcription factors...
- RANKL maintains bone homeostasis through c-Fos-dependent induction of interferon-betaHiroshi Takayanagi
Department of Immunology, Faculty of Medicine and Graduate School of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 0033, Japan
Nature 416:744-9. 2002..Our study places the IFN-beta system in a new context, and may offer a molecular basis for the treatment of bone diseases...
- The proto-oncoprotein c-Fos negatively regulates hepatocellular tumorigenesisMario Mikula
Institute of Cancer Research, University of Vienna, Borschke Gasse 8a, A 1090 Vienna, Austria
Oncogene 22:6725-38. 2003..Taken together, we demonstrate that c-Fos modulates plasticity of epithelial hepatocytes and acts tumour suppressive in neoplastic hepatocytes by stimulating cell cycle inhibition and cell death...
- Regulation of osteoclast differentiation and function by the CaMK-CREB pathwayKojiro Sato
Department of Cell Signaling, Graduate School, Tokyo Medical and Dental University, Japan
Nat Med 12:1410-6. 2006..This provides a molecular basis for a new therapeutic strategy for bone diseases...
- NF-kappaB p50 and p52 regulate receptor activator of NF-kappaB ligand (RANKL) and tumor necrosis factor-induced osteoclast precursor differentiation by activating c-Fos and NFATc1Teruhito Yamashita
Department of Pathology and Laboratory Medicine and Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, New York 14642, USA
J Biol Chem 282:18245-53. 2007..Inhibition of NF-kappaB should prevent RANKL- and TNF-induced bone resorption...
- Pdcd4 suppresses tumor phenotype in JB6 cells by inhibiting AP-1 transactivationHsin Sheng Yang
Gene Regulation Section, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA
Oncogene 22:3712-20. 2003..Thus, Pdcd4 suppresses tumor phenotype by inhibiting AP-1-dependent transcription, possibly through inhibiting c-Jun and c-Fos activation...
- IL-1ra alleviates inflammatory hyperalgesia through preventing phosphorylation of NMDA receptor NR-1 subunit in ratsRui Xin Zhang
Center for Integrative Medicine, School of Medicine, University of Maryland, Baltimore, MD 21201, USA
Pain 135:232-9. 2008..05) and inhibited NR1 phosphorylation compared to saline control. The results suggest that spinal IL-1beta is produced by astrocytes and enhances NR1 phosphorylation to facilitate inflammatory pain...
- Fos-related antigen 1 modulates malignant features of glioma cellsWaldemar Debinski
Brain Tumor Center of Excellence, Department of Neurosurgery, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
Mol Cancer Res 3:237-49. 2005..Thus, Fra-1 may likely play an important role in the maintenance/progression of malignant gliomas and potentially represents a new target for therapeutic interventions...
- Nesfatin-1 neurons in paraventricular and supraoptic nuclei of the rat hypothalamus coexpress oxytocin and vasopressin and are activated by refeedingDaisuke Kohno
Division of Integrative Physiology, Department of Physiology, Jichi Medical University, School of Medicine, Tochigi 329 0498, Japan
Endocrinology 149:1295-301. 2008..Feeding-activated nesfatin-1 neurons in the PVN and SON could play a role in the postprandial regulation of feeding behavior and energy homeostasis...
- Reduced food anticipatory activity in genetically orexin (hypocretin) neuron-ablated miceMasashi Akiyama
Department of Pharmacology, School of Science and Engineering, Waseda University, 2 7 5 Higashifushimi, Nishitokyo, 202 0021, Japan
Eur J Neurosci 20:3054-62. 2004..Based on these results, we suggest that activity of the orexin neuron in the LHA contributes to the promotion and maintenance of FAA...
- Fos-related antigen (Fra-1), junB, and junD activate human involucrin promoter transcription by binding to proximal and distal AP1 sites to mediate phorbol ester effects on promoter activityJ F Welter
Department of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106 4970, USA
J Biol Chem 270:12614-22. 1995....
- FOS-1 promotes basement-membrane removal during anchor-cell invasion in C. elegansDavid R Sherwood
HHMI and Division of Biology, California Institute of Technology, 1200 East California Boulevard, Pasadena, California 91125, USA
Cell 121:951-62. 2005..These results reveal a key genetic network that controls basement-membrane removal during cell invasion...
- Prognostic significance of loss of c-fos protein in gastric carcinomaSeon Pil Jin
Department of Pathology, Seoul National University College of Medicine, Seoul, Korea
Pathol Oncol Res 13:284-9. 2007..The above findings suggest that loss of c-fos expression has tumor suppressor activity in gastric cancer and we suspect that this suppressor activity might be related to the pro-apoptotic function of c-fos...
- Phosphorylation of the carboxyl-terminal transactivation domain of c-Fos by extracellular signal-regulated kinase mediates the transcriptional activation of AP-1 and cellular transformation induced by platelet-derived growth factorPaula Monje
Oral and Pharyngeal Cancer Branch, National Institute of Dental Research, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892 4330, USA
Mol Cell Biol 23:7030-43. 2003..Furthermore, we provide evidence that the ERK-dependent activation of c-Fos is an integral component of the mitogenic pathway by which PDGF regulates normal and aberrant cell growth...
- Anatomical markers of activity in neuroendocrine systems: are we all 'fos-ed out'?G E Hoffman
Department of Anatomy and Neurobiology, Program in Neuroscience, University of Maryland, School of Medicine, 685 W Baltimore Street, Baltimore, MD 21201, USA
J Neuroendocrinol 14:259-68. 2002..Together, as we move into the 21st Century, the use of multiple approach to study activity within neuroendocrine systems will further our understanding of these important systems...
- Molecular basis of long-term plasticity underlying addictionE J Nestler
Department of Psychiatry and Center for Basic Neuroscience, University of Texas Southwestern Medical Center, 5, 323 Harry Hines Boulevard, Dallas, Texas 75390 9070, USA
Nat Rev Neurosci 2:119-28. 2001....
- Phosphorylation of c-Fos by members of the p38 MAPK family. Role in the AP-1 response to UV lightTamara Tanos
Laboratorio de Fisiologia y Biologia Molecular, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, IFIBYNE CONICET, 1428 Buenos Aires, Argentina
J Biol Chem 280:18842-52. 2005..Thus, these newly described pathways act concomitantly with the activation of c-Jun by JNK/MAPKs, thereby contributing to the complexity of AP1-driven gene transcription regulation...
- Molecular interpretation of ERK signal duration by immediate early gene productsLeon O Murphy
Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA
Nat Cell Biol 4:556-64. 2002..Together, our data identify a general mechanism by which cells can interpret differences in ERK activation kinetics...
- Peripheral administration of nesfatin-1 reduces food intake in mice: the leptin-independent mechanismH Shimizu
Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Japan
Endocrinology 150:662-71. 2009..Our findings indicate that the midsegment of nesfatin-1 causes anorexia, possibly by activating POMC and CART neurons in the NTS via a leptin-independent mechanism after peripheral stimulation...
- Using c-fos as a neural marker of painJ A Harris
School of Psychology, The University of New South Wales, Sydney, Australia
Brain Res Bull 45:1-8. 1998..The increasing use of c-fos to study nociception necessitates a critical review of the practice, identifying the shortcomings as well as the strengths of this tool...
- Distinct roles of Jun : Fos and Jun : ATF dimers in oncogenesisH van Dam
Department of Molecular Cell Biology, Leiden University Medical Center, Sylvius Laboratories, PO Box 9503, 2300 RA Leiden, The Netherlands
Oncogene 20:2453-64. 2001..Further genetic studies with Jun dimerization mutants will be required to be precise and extend the specific roles of the Jun : Fos and Jun : ATF dimers during cancer progression in avian and mammalian systems...
- Crocidolite asbestos and SV40 are cocarcinogens in human mesothelial cells and in causing mesothelioma in hamstersBarbara Kroczynska
Thoracic Oncology Program, Cardinal Bernardin Cancer Center, Loyola University Chicago, Maywood, IL 60153, USA
Proc Natl Acad Sci U S A 103:14128-33. 2006..Our results indicate that mineral fibers and viruses can be cocarcinogens and suggest that lower amounts of asbestos may be sufficient to cause MM in individuals infected with SV40...
- Heat hyperalgesia after incision requires TRPV1 and is distinct from pure inflammatory painEsther M Pogatzki-Zahn
Department of Anesthesiology, Johns Hopkins University, Baltimore, MD, USA
Pain 115:296-307. 2005..Thus, TRPV1 is important for the generation of thermal hyperalgesia after incision. Our observations suggest that all experimental pain models may not be equally appropriate to guide the development of postoperative pain therapies...
- The rat ponto-medullary network responsible for paradoxical sleep onset and maintenance: a combined microinjection and functional neuroanatomical studyRomuald Boissard
CNRS FRE 2469, Institut Fédératif des Neurosciences de Lyon IFR 19, Universite Claude Bernard Lyon I, 8 avenue Rockefeller, 69373 Lyon Cedex 08, France
Eur J Neurosci 16:1959-73. 2002..Furthermore, they suggest that GABAergic disinhibition and glutamate excitation of these neurons might also play a crucial role in the onset of PS...
- Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-beta-induced transcriptionY Zhang
Department of Growth and Development, Program in Cell Biology, University of California at San Francisco, 94143 0640, USA
Nature 394:909-13. 1998..This mechanism of transcriptional activation by TGF-beta, through functional and physical interactions between Smad3-Smad4 and c-Jun-c-Fos, shows that Smad signalling and MAPK/JNK signalling converge at AP1-binding promoter sites...
- c-Fos activated phospholipid synthesis is required for neurite elongation in differentiating PC12 cellsGermán A Gil
Centro de Investigaciones en Química Biológica de Córdoba Consejo Nacional de Investigaciones Científicas y Técnicas, Departamento de Quimica Biologica, Facultad de Ciencias Quimicas, Universidad Nacional de Cordoba, 5000 Cordoba, Argentina
Mol Biol Cell 15:1881-94. 2004..Because phospholipids are key membrane components, we hypothesize this latter phenomenon as crucial to support membrane genesis demands required for cell growth and neurite elongation...
- Close encounters of many kinds: Fos-Jun interactions that mediate transcription regulatory specificityY Chinenov
Howard Hughes Medical Institute, University of Michigan Medical School Ann Arbor, Michigan, MI 48109-0650, USA
Oncogene 20:2438-52. 2001..The gene-specific architecture of these complexes can mediate the selective control of transcriptional activity...
- Constitutive activation of nuclear factor kappaB p50/p65 and Fra-1 and JunD is essential for deregulated interleukin 6 expression in prostate cancerLuiz F Zerbini
BIDMC Genomics Center and New England Baptist Bone and Joint Institute, Boston, Massachusetts 02115, USA
Cancer Res 63:2206-15. 2003....
- Long-term monitoring of circadian rhythms in c-fos gene expression from suprachiasmatic nucleus culturesM E Geusz
NSF Center for Biological Timing, University of Virginia, Charlottesville 22903, USA
Curr Biol 7:758-66. 1997..Here, we have devised a method of continuously measuring c-fos expression...
- c-Fos expression in hypothalamic nuclei of food-entrained ratsManuel Angeles-Castellanos
Departamento de Anatomia, Facultad de Medicina, Instituto de Fisiologia Celular, Universidad Nacional Autonoma de Mexico, Mexico City DF 04510, Mexico
Am J Physiol Regul Integr Comp Physiol 286:R158-65. 2004..We can suggest that the PeF and TM may be involved with the arousal state during food anticipation and the DMH and LH with the time-keeping mechanism of FEO or its output...
- Cholinergic and noncholinergic brainstem neurons expressing Fos after paradoxical (REM) sleep deprivation and recoveryLaure Verret
CNRS UMR 5167, Institut Fédératif des Neurosciences de Lyon IFR 19, Faculté de médecine RTH Laennec, 7, Rue Guillaume Paradin, 69372 Lyon Cedex 08, France
Eur J Neurosci 21:2488-504. 2005..Altogether, our results open a new avenue of research to identify the specific role of the populations of neurons revealed, their interrelations and their neurochemical identity...
- Effects of honokiol and magnolol on acute and inflammatory pain models in miceYi Ruu Lin
Institute of Medical Sciences, Tzu Chi University, Hualien, Taiwan
Life Sci 81:1071-8. 2007..These results demonstrate that honokiol and magnolol effectively alleviate the formalin-induced inflammatory pain without motor and cognitive side effects, suggesting their therapeutic potential in the treatment of inflammatory pain...
- A role of melanin-concentrating hormone producing neurons in the central regulation of paradoxical sleepLaure Verret
CNRS UMR5167, Institut Fédératif des Neurosciences de Lyon IFR 19, Universite Claude Bernard Lyon I, 7 rue Guillaume Paradin, 69372 Lyon Cedex 08, France
BMC Neurosci 4:19. 2003..Next, we compared the effect of MCH and NaCl intracerebroventricular (ICV) administrations on sleep stage quantities to further determine whether MCH neurons play an active role in PS regulation...
- c-Fos as a proapoptotic agent in TRAIL-induced apoptosis in prostate cancer cellsXiaoping Zhang
Department of Urology, Massachusetts General Hospital, Boston, MA 02114, USA
Cancer Res 67:9425-34. 2007..Strategies to activate c-Fos or inhibit c-FLIP(L) may potentiate TRAIL-based proapoptotic therapies...
- Localization of the neurons active during paradoxical (REM) sleep and projecting to the locus coeruleus noradrenergic neurons in the ratLaure Verret
Centre National de la Recherche Scientifique, Unité Mixte de Recherche 5167, Institut Fédératif des Neurosciences de Lyon IFR19, Lyon F 69372, France
J Comp Neurol 495:573-86. 2006..Although all these populations of CTb/Fos double-labeled neurons could be GABAergic and tonically inhibit LC neurons during PS, our results indicate that neurons from the DPGi constitute the best candidate for this role...
- The Fos-related antigen Fra-1 is an activator of bone matrix formationRobert Eferl
Research Institute of Molecular Pathology IMP, Vienna, Austria
EMBO J 23:2789-99. 2004..These results uncover a novel function of Fra-1 in regulating bone mass through bone matrix production by osteoblasts and chondrocytes...
- DNA binding activities of three murine Jun proteins: stimulation by FosY Nakabeppu
Howard Hughes Medical Institute Laboratory, Baltimore, Maryland
Cell 55:907-15. 1988..If there are functional differences between them, they are likely to involve other activities of the Jun proteins...
- Rhabdomyosarcoma development in mice lacking Trp53 and Fos: tumor suppression by the Fos protooncogeneAlexander Fleischmann
Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030 Vienna, Austria
Cancer Cell 4:477-82. 2003..Moreover, Fos is able to repress Pax7 expression in rhabdomyosarcoma cell lines and primary myoblasts, suggesting a molecular link to genetic alterations involved in human rhabdomyosarcomas...
- CCK-8S activates c-Fos in a dose-dependent manner in nesfatin-1 immunoreactive neurons in the paraventricular nucleus of the hypothalamus and in the nucleus of the solitary tract of the brainstemSteffen Noetzel
Department of Medicine, Division Hepatology, Gastroenterology, and Endocrinology Charité, Campus Virchow Universitätsmedizin Berlin, Germany
Regul Pept 157:84-91. 2009..No effect on the number of c-Fos-ir neurons was observed in the ARC. These results suggest that the effects of CCK on the HPA axis and on food intake may, at least in part, be mediated by nesfatin-1-ir neurons in the PVN...
- Patterns of brain activity associated with variation in voluntary wheel-running behaviorJustin S Rhodes
Department of Zoology, University of Wisconsin Madison, 53706, USA
Behav Neurosci 117:1243-56. 2003..Results implicate specific brain regions in motivation to run and others in control of the intensity of the locomotor behavior itself...
- Comparison of c-fos-like immunoreactivity in the brainstem following intraoral and intragastric infusions of chemical solutions in ratsT Yamamoto
Department of Behavioral Physiology, Faculty of Human Sciences, Osaka University, 1 2 Yamadaoka, Suita, 565 0871, Osaka, Japan
Brain Res 866:144-51. 2000..These results indicate that c-fos induction in brainstem neurons during ingestion reflects gustatory inputs and postingestional factors depending on the kind of food ingested...
- Regulation of DeltaFosB stability by phosphorylationPaula G Ulery
Department of Psychiatry, Center for Basic Neuroscience, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9070, USA
J Neurosci 26:5131-42. 2006..These findings constitute the first evidence that DeltaFosB is phosphorylated and demonstrate that phosphorylation contributes to its stability, which is at the core of its ability to mediate long-lasting adaptations in brain...
- A role for glucagon-like peptide-1 in the central regulation of feedingM D Turton
Department of Medicine, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK
Nature 379:69-72. 1996..Both of these regions of the brain are of primary importance in the regulation of feeding. These findings suggest that central GLP-1 is a new physiological mediator of satiety...
- The structural determinants responsible for c-Fos protein proteasomal degradation differ according to the conditions of expressionPatrizia Ferrara
Institut de Genetique Moleculaire, Montpellier Cedex, France
Oncogene 22:1461-74. 2003..Moreover, they also indicate that the half-life of c-Fos during the G0/G1 phase transition is determined by a delicate balance between opposing stabilizing and destabilizing mechanisms operating at the same time...
- DeltaFosB: a molecular switch for long-term adaptation in the brainColleen A McClung
Department of Psychiatry and Center for Basic Neuroscience, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9070, USA
Brain Res Mol Brain Res 132:146-54. 2004....
- C-Fos elimination compensates for disabled-2 requirement in mouse extraembryonic endoderm developmentDong Hua Yang
Ovarian Cancer Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA
Dev Dyn 238:514-23. 2009....
- The nucleosomal response associated with immediate-early gene induction is mediated via alternative MAP kinase cascades: MSK1 as a potential histone H3/HMG-14 kinaseS Thomson
Nuclear Signalling Laboratory, The Randall Institute, King s College, London, WC2B 5RL, UK
EMBO J 18:4779-93. 1999..Thus, the nucleosomal response is an invariable consequence of ERK and p38 but not JNK/SAPK activation, and MSK1 potentially provides a link to complete the circuit between cell surface and nucleosome...
- ERK-MAPK signaling coordinately regulates activity of Rac1 and RhoA for tumor cell motilityEmmanuel Vial
Cancer Research UK Centre for Cell and Molecular Biology, Institute of Cancer Research, 237 Fulham Road, London, SW3 6JB, United Kingdom
Cancer Cell 4:67-79. 2003....
- Crystal structure of the heterodimeric bZIP transcription factor c-Fos-c-Jun bound to DNAJ N Glover
Howard Hughes Medical Institute, Harvard University, Cambridge, Massachusetts 02138
Nature 373:257-61. 1995..There is an extensive network of electrostatic interactions between subunits within the coiled-coil, consistent with proposals that these interactions determine preferential formation of the heterodimer over either of the homodimers...
- Null mutation of c-fos impairs structural and functional plasticities in the kindling model of epilepsyY Watanabe
Department of Medicine Neurology, Duke University Medical Center, Durham, North Carolina 27710, USA
J Neurosci 16:3827-36. 1996..We favor the hypothesis that this "fos-less phenotype" is attributable to impaired seizure-induced transcriptional activation of one or more growth-related genes...
- A growth factor-induced kinase phosphorylates the serum response factor at a site that regulates its DNA-binding activityV M Rivera
Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts 02115
Mol Cell Biol 13:6260-73. 1993....
- Activation of capsaicin receptors on the sciatic nerve induces FOS expression in the spinal dorsal horn of adult ratsYu Peng Feng
Department of Anatomy and K K Leung Brain Research Centre, The Fourth Military Medical University, Xi an, People s Republic of China
Neurosignals 11:151-7. 2002....
- The transcription factor Fos: a Janus-type regulator in health and diseaseMoritz Durchdewald
German Cancer Research Center DKFZ, DKFZ ZMBH Alliance, Division of Signal Transduction and Growth Control, Heidelberg, Germany
Histol Histopathol 24:1451-61. 2009..Finally, selective inhibition of its function with a small molecule inhibitor in a preclinical mouse model of arthritis demonstrated that targeting Fos/AP-1 activity could be an auspicious new option for clinical use...
- CART in the dorsal vagal complex: sources of immunoreactivity and effects on Fos expression and food intakeHuiyuan Zheng
Neurobiology of Nutrition Laboratory, Pennington Biomedical Research Center, Louisiana State University, 6400 Perkins Road, Baton Rouge, LA 70808, USA
Brain Res 957:298-310. 2002..The functional role of CART in vagal afferents and the site of food intake suppression by 4th ventricular CARTp remain to be determined...
- Yeast zymosan, a stimulus for TLR2 and dectin-1, induces regulatory antigen-presenting cells and immunological toleranceStephanie Dillon
Emory Vaccine Research Center and Department of Pathology, Emory University, Atlanta, Georgia 30329, USA
J Clin Invest 116:916-28. 2006..These data suggest several targets for pharmacological modulation of immune responses in various clinical settings...
- Disassociation of MAPK activation and c-Fos expression in F9 embryonic carcinoma cells following retinoic acid-induced endoderm differentiationE R Smith
Ovarian Cancer Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
J Biol Chem 276:32094-100. 2001....
- Activation of c-fos in GABAergic neurones in the preoptic area during sleep and in response to sleep deprivationHui Gong
Department of Psychology, School of Medicine, University of California, Los Angeles, CA, USA
J Physiol 556:935-46. 2004..They also demonstrate that sleep deprivation is associated with increased activation of GABAergic neurones in the MnPN and vlPOA...
- Infralimbic cortex activation increases c-Fos expression in intercalated neurons of the amygdalaS Berretta
Translational Neuroscience Laboratory, McLean Hospital, Belmont, MA 02478, USA
Neuroscience 132:943-53. 2005..Thus, our findings raise the possibility that the infralimbic cortex inhibits conditioned fear via the excitation of intercalated cells and the consequent inhibition of central amygdala neurons...
- Disabled-2 exerts its tumor suppressor activity by uncoupling c-Fos expression and MAP kinase activationJ He
Ovarian Cancer Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
J Biol Chem 276:26814-8. 2001..Because Dab2 is frequently lost in cancer, the uncoupling of MAPK activation and c-Fos expression may be a favored target for inactivation in tumorigenicity...
- Gene expression profiling in prostate cancer cells with Akt activation reveals Fra-1 as an Akt-inducible geneGunjan Tiwari
Department of Molecular Pharmacology, Stanford University and Department of Pathology, Stanford University School of Medicine, Stanford, CA
Mol Cancer Res 1:475-84. 2003..Moreover, the identification of Fra-1 as an Akt-regulated gene may have implications for the ability of Akt to transform cells since Fra-1 has been implicated in cell growth and the aggressiveness of tumors...
- Signaling pathways leading to transcription and translation cooperatively regulate the transient increase in expression of c-Fos proteinK Takeuchi
Department of Biochemistry, Faculty of Pharmaceutical Sciences, Setsunan University, Hirakata, Osaka 573-0101, Japan
J Biol Chem 276:26077-83. 2001..Regulation of the translation process of c-fos mRNA in addition to the immediate activation of c-fos transcription is necessary for the transient increase in the level of c-Fos protein to stimulate cell proliferation...
- Cutting edge: different Toll-like receptor agonists instruct dendritic cells to induce distinct Th responses via differential modulation of extracellular signal-regulated kinase-mitogen-activated protein kinase and c-FosSudhanshu Agrawal
Emory Vaccine Center, Atlanta, GA 30329, USA
J Immunol 171:4984-9. 2003..Thus, distinct TLR agonists differentially modulate extracellular signal-regulated kinase signaling, c-Fos activity, and cytokine responses in DCs to stimulate different Th responses...
- Differential induction of nuclear factor-kappaB and activator protein-1 activity after CD40 ligation is associated with primary human hepatocyte apoptosis or intrahepatic endothelial cell proliferationJalal Ahmed-Choudhury
Liver Research Laboratories, Medical Research Council Centre for Immune Regulation, University of Birmingham Institute of Clinical Science, Queen Elizabeth Hospital, Edgbaston, Birmingham, B15 2TH, United Kingdom
Mol Biol Cell 14:1334-45. 2003..Transient activation of NF-kappaB and sustained AP-1 activation is associated with apoptosis in hepatocytes, whereas prolonged NF-kappaB activation and a lack of AP-1 activation in IHECs result in proliferation...
- Activator protein 1 DNA binding activity is decreased in lesional psoriatic skin compared with nonlesional psoriatic skinC Johansen
Department of Dermatology, Marselisborg Hospital, University of Aarhus, P P Orumsgade 11, DK 8000 Aarhus C, Denmark
Br J Dermatol 151:600-7. 2004..The transcription factor activator protein 1 (AP-1) is known to play an important role in cell proliferation and differentiation...
- Task-dependent and cell-type-specific Fos enhancement in rat sensory cortices during audio-visual discriminationShuzo Sakata
Speciation Mechanisms I, National Institute for Basic Biology, Okazaki 444 8585, Japan
Eur J Neurosci 15:735-43. 2002..These results suggest that modulation in cortical excitatory neurons might have critical roles in selecting and processing behaviourally relevant sensory stimuli...
- Blockade of central GLP-1 receptors prevents CART-induced hypophagia and brain c-Fos expressionSusan Aja
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 720 Rutland Avenue, Ross 618, Baltimore, MD 21205, USA
Peptides 27:157-64. 2006..These data suggest that i.c.v. CART administration activates a central release of GLP-1 to inhibit feeding and produce widespread neural activation...
- A recombinant human glucagon-like peptide (GLP)-1-albumin protein (albugon) mimics peptidergic activation of GLP-1 receptor-dependent pathways coupled with satiety, gastrointestinal motility, and glucose homeostasisLaurie L Baggio
Toronto General Hospital, Banting and Best Diabetes Centre, 200 Elizabeth St, MBRW4R 402, Toronto, Canada
Diabetes 53:2492-500. 2004..These findings illustrate that peripheral administration of a larger peptide-albumin recombinant protein mimics GLP-1R-dependent activation of central and peripheral pathways regulating energy intake and glucose homeostasis in vivo...
- Induction of c-Fos expression in specific areas of the fear circuitry in rat forebrain by anxiogenic drugsNicolas Singewald
Department of Pharmacology and Toxicology, University of Innsbruck, Innsbruck, Austria
Biol Psychiatry 53:275-83. 2003..The fact that induction of anxiety- and panic-related symptoms is a property common to a range of drugs suggests that common neural substrates underlie their behavioral effects...
- Fra-1 expression in malignant and benign thyroid tumorY H Kim
Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea
Korean J Intern Med 16:93-7. 2001....
- Identification of a C-terminal tripeptide motif involved in the control of rapid proteasomal degradation of c-Fos proto-oncoprotein during the G(0)-to-S phase transitionC Acquaviva
Institute of Molecular Genetics, UMR5535/IFR24, CNRS, 1919, route de Mende, 34293-Montpellier Cedex 05, France
Oncogene 20:7563-72. 2001..We, however, showed that the PTL motif does not exert its effect by counteracting a stabilizing effect of these phosphorylations under our experimental conditions...
- Autoamplification of NFATc1 expression determines its essential role in bone homeostasisMasataka Asagiri
Department of Cell Signaling, Tokyo Medical and Dental University, Japan
J Exp Med 202:1261-9. 2005..Thus, this study establishes that NFATc1 represents a potential therapeutic target for bone disease and reveals a mechanism that underlies the essential role of NFATc1 in bone homeostasis...
- Regulation of fosB and DeltafosB mRNA expression: in vivo and in vitro studiesImran N Alibhai
Department of Psychiatry and Center for Basic Neuroscience, The University of Texas Southwestern Medical Center, Dallas, TX 75390 9070, USA
Brain Res 1143:22-33. 2007....
- Neoplastic transformation of rat thyroid cells requires the junB and fra-1 gene induction which is dependent on the HMGI-C gene productD Vallone
Istituto Internazionale di Genetica e Biofisica, CNR, Via Guglielmo Marconi 12, I 80125 Naples, Italy
EMBO J 16:5310-21. 1997....
- DEP-induced fra-1 expression correlates with a distinct activation of AP-1-dependent gene transcription in the lungQin Zhang
The Johns Hopkins University, Department of Environmental Health Sciences, Bloomberg School of Public Health, Baltimore, MD 21205, USA
Am J Physiol Lung Cell Mol Physiol 286:L427-36. 2004..Collectively, these findings suggest that fra-1 induction by DEP may play a role in selectively regulating gene expression involved in alveolar epithelial cell injury and repair...
- Overexpression of Fos-related antigen-1 in head and neck squamous cell carcinomaFlavia R R Mangone
Faculdade de Medicina da Universidade de Sao Paulo, Departamento de Radiologia, Disciplina de Oncologia, 01246 903 Sao Paulo, Brazil
Int J Exp Pathol 86:205-12. 2005..0005). Thus, Fra-1 gene induction and accumulation of Fra-1 protein may contribute to the neoplastic phenotype in HNSCC...
- The ability of Fos family members to produce phenotypic changes in epithelioid cells is not directly linked to their transactivation potentialsHenriette Andersen
Danish Cancer Society, Department of Molecular Cancer Biology, Strandboulevarden 49, DK 2100, Copenhagen Ø, Denmark
Oncogene 21:4843-8. 2002..We therefore conclude that c-Fos, Fra-1 and Fra-2 differently activate transcription of target genes and induce morphological changes in epithelioid carcinoma cells in a manner not directly linked to their transactivation potentials...
- NF-kappaB and AP-1 connection: mechanism of NF-kappaB-dependent regulation of AP-1 activityShuichi Fujioka
Department of Surgical Oncology, Box 107, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
Mol Cell Biol 24:7806-19. 2004..Thus, our study revealed a distinct and essential role of NF-kappaB in participating in the regulation of elk-1, c-fos, and VEGF expression...
- Glucagon-like peptide-1 receptor stimulation increases blood pressure and heart rate and activates autonomic regulatory neuronsHiroshi Yamamoto
Department of Medicine and Division of Endocrinology, Beth Israel Deaconess Medical Center, Harvard Medical School, 99 Brookline Avenue, Boston, MA 02215, USA
J Clin Invest 110:43-52. 2002..These findings suggest that the central GLP-1 system represents a regulator of sympathetic outflow leading to downstream activation of cardiovascular responses in vivo...
- A mechanism for translationally coupled mRNA turnover: interaction between the poly(A) tail and a c-fos RNA coding determinant via a protein complexC Grosset
Department of Biochemistry and Molecular Biology, The University of Texas Houston Medical School 77030, USA
Cell 103:29-40. 2000..We propose that a bridging complex forms between the poly(A) tail and the mCRD and ribosome transit disrupts or reorganizes the complex, leading to rapid RNA deadenylation and decay...
- Fos, nociception and the dorsal hornRichard E Coggeshall
Neuroscience and Cell Biology, The University of Texas Medical Branch, Galveston, TX 77555 1069, USA
Prog Neurobiol 77:299-352. 2005..Thus, the purpose of this review is to summarize the studies whose numbers are geometrically expanding that deal with Fos in the dorsal horn and the conclusions therefrom...
- The forced swimming-induced behavioural immobility response involves histone H3 phospho-acetylation and c-Fos induction in dentate gyrus granule neurons via activation of the N-methyl-D-aspartate/extracellular signal-regulated kinase/mitogen- and stress-aYalini Chandramohan
Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, Dorothy Hodgkin Building, University of Bristol, Whitson Street, Bristol BS1 3NY, UK
Eur J Neurosci 27:2701-13. 2008..We conclude that the forced swimming-induced behavioural immobility response requires histone H3 phospho-acetylation and c-Fos induction in distinct dentate granule neurons through recruitment of the NMDA/ERK/MSK 1/2 pathway...
- AP-1 in mouse development and tumorigenesisW Jochum
Research Institute of Molecular Pathology (I.M.P, Dr. Bohr-Gasse 7, A-1030 Vienna, Austria
Oncogene 20:2401-12. 2001....
- c-Fos transcriptional activity stimulated by H-Ras-activated protein kinase distinct from JNK and ERKT Deng
Department of Pharmacology, University of California at San Diego School of Medicine, La Jolla 92093 0636
Nature 371:171-5. 1994..Therefore, at least three types of proline-directed kinases transmit Ras- and mitogen-generated signals to the transcriptional machinery...
- Jun signalling in the epidermis: From developmental defects to psoriasis and skin tumorsRainer Zenz
Research Institute of Molecular Pathology I M P, Dr Bohr Gasse 7, A 1030 Vienna, Austria
Int J Biochem Cell Biol 38:1043-9. 2006....
- Fos/AP-1 proteins in bone and the immune systemErwin F Wagner
Research Institute of Molecular Pathology IMP, Vienna, Austria
Immunol Rev 208:126-40. 2005..We also attempt to put potential therapeutic strategies for inflammatory bone diseases in perspective...
- Essential role of the fosB gene in molecular, cellular, and behavioral actions of chronic electroconvulsive seizuresN Hiroi
Laboratory of Molecular Psychiatry, Departments of Psychiatry and Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06508, USA
J Neurosci 18:6952-62. 1998..These findings identify fosB gene products as transcription factors critical for molecular, electrophysiological, and behavioral adaptations to motor seizures...
- Molecular basis for the recognition of phosphorylated and phosphoacetylated histone h3 by 14-3-3Neil MacDonald
Syngenta Central Toxicology Laboratory, Alderley Park, Macclesfield, SK10 4TJ, United Kingdom
Mol Cell 20:199-211. 2005..14-3-3 isoforms thus represent a class of proteins that mediate the effect of histone phosphorylation at inducible genes...
- Superficial NK1-expressing neurons control spinal excitability through activation of descending pathwaysRie Suzuki
Department of Pharmacology, University College London, Gower Street, London WC1E 6BT, UK
Nat Neurosci 5:1319-26. 2002....
- Resistance to extinction is associated with impaired immediate early gene induction in medial prefrontal cortex and amygdalaCyril Herry
Laboratoire de Neurosciences Cognitives, CNRS UMR 5106, Universite de Bordeaux I, Avenue des Facultes, 33405 Talence, France
Eur J Neurosci 20:781-90. 2004..This suggests that coordinated activity-dependent changes in gene expression in the mPFC and the amygdala may underlie the formation of long-term fear extinction memory...
- Protein kinase A and AP-1 (c-Fos/JunD) are induced during apoptosis of mouse mammary epithelial cellsA Marti
Laboratory for Clinical and Experimental Research, University of Bern, Switzerland
Oncogene 9:1213-23. 1994..A similar induction of AP-1 (cFos/JunD) was also observed in the involuting rat ventral prostate pointing to a possible role for AP-1 in programmed cell death...
- Neurobiological correlates of high (HAB) versus low anxiety-related behavior (LAB): differential Fos expression in HAB and LAB ratsNicolas Salome
Laboratoire de Stress Périnatal, Universite de Lille 1, Villeneuve d Ascq, France
Biol Psychiatry 55:715-23. 2004..Two Wistar rat lines selectively bred for either high (HAB) or low (LAB) anxiety-related behavior were used to identify neurobiological correlates of trait anxiety...
- Cell transformation by c-fos requires an extended period of expression and is independent of the cell cycleG G Miao
Roche Institute of Molecular Biology, Nutley, New Jersey 07110
Mol Cell Biol 14:4295-310. 1994..Our results suggest that cell transformation by Fos requires increased expression of a target gene(s) with a long-lived product(s) that must reach a critical level...
- Urocortin II: a member of the corticotropin-releasing factor (CRF) neuropeptide family that is selectively bound by type 2 CRF receptorsT M Reyes
Laboratory of Neuronal Structure and Function, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
Proc Natl Acad Sci U S A 98:2843-8. 2001..Initial functional studies are consistent with Ucn II involvement in central autonomic and appetitive control, but not in generalized behavioral activation...
- Intraretinal signaling by ganglion cell photoreceptors to dopaminergic amacrine neuronsDao Qi Zhang
Department of Biological Sciences, Vanderbilt University, Nashville, TN 37235, USA
Proc Natl Acad Sci U S A 105:14181-6. 2008..This unprecedented centrifugal outflow of ganglion-cell signals within the retina provides a novel basis for the restructuring of retinal circuits by light...
- The transcription activation domains of Fos and Jun induce DNA bending through electrostatic interactionsT K Kerppola
Howard Hughes Medical Institute and Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor 48109 0650, USA
EMBO J 16:2907-16. 1997..Consequently, regions outside the minimal DNA-binding domain can influence DNA structure, and may thereby contribute to the architectural reorganization of the promoter region required for gene activation...
- Impaired extinction of learned fear in rats selectively bred for high anxiety--evidence of altered neuronal processing in prefrontal-amygdala pathwaysPatrik Muigg
Department of Pharmacology and Toxicology, Institute of Pharmacy, Center for Molecular Biosciences Innsbruck, University of Innsbruck, Peter Mayer Strasse 1, A 6020 Innsbruck, Austria
Eur J Neurosci 28:2299-309. 2008..Thus, HAB rats may represent a clinically relevant model to study the mechanisms and potential targets to accelerate delayed extinction processes in subjects with enhanced trait anxiety...
- Research Initiative for Scientific Enhancement 2009-2013PAUL T BUONORA; Fiscal Year: 2012..abstract_text> ..
- ONTOGENY OF NEUROADAPTIVE RESPONSES TO PSYCHOSTIMULANTSMichelle Ehrlich; Fiscal Year: 2002..abstract_text> ..
- Morphine-induced chronic Fra upregulationDANIELLA LANCELLOTTI; Fiscal Year: 2004..abstract_text> ..
- Social Stress and Sensorimotor Gating Deficits in RatsRONALD HAMMER; Fiscal Year: 2006....
- BASAL GANGLIA CIRCUITRY IMMEDIATE EARLY GENE EXPRESSIONDavid Wirtshafter; Fiscal Year: 2003..Other studies will examine the effects of lesions within the basal ganglia on the IEG expression induced by systemic administration of dopaminergic drugs. ..
- Lateral Hypothalamus, Dopamine and Ingestive BehaviorDavid Wirtshafter; Fiscal Year: 2007..Gaining an understanding of these systems is a prerequisite for the rational development of novel treatments for disturbances of ingestion, such as occur in obesity, bulemia and cahchexia. [unreadable] [unreadable] [unreadable]..
- Cue dependency with intravenous nutrients and nicotineNeil Rowland; Fiscal Year: 2007..These studies may help to develop ways in conditioned preferences can be manipulated to prevent or treat certain addictive disorders, including overeating. [unreadable] [unreadable] [unreadable]..
- Molecular Basis of D1 and D2 PrimingAlexia Pollack; Fiscal Year: 2003..Elucidation of this mechanism could lead to treatment strategies aimed to prevent these dyskinesias, which would, in turn, lengthen the time that dopamine replacement therapy is effective to treat patients with PD. ..
- Role of Fra-1 in MesotheliomaMaria Ramos Nino; Fiscal Year: 2008..The long-term goal of this research plan is to understand the molecular mechanisms governing mesothelial cell tumorigenesis. ..
- Physiology and genetics of food procurement in rodentsNeil Rowland; Fiscal Year: 2008..The proposed studies will be the first to address the issue of behavioral change induced by anorectics under such conditions of simulated economic costs. [unreadable] [unreadable] [unreadable]..
- NEURAL AND GI SUBSTRATES IN BOMBESIN SATIETYELLEN LADENHEIM; Fiscal Year: 2006..Such an understanding will significantly enhance our understanding of the mechanisms underlying overall energy regulation and may lead to novel treatments for obesity or eating disorders ..
- Hindbrain mechanisms of hypoglycemia unawarnessSue Ritter; Fiscal Year: 2005..Corticosterone infusions and specific stressors with differing effects on corticosterone secretion will be examined for their ability to induce HAAF. ..
- CNS Estrogen Receptors and Social BehaviorBRUCE CUSHING; Fiscal Year: 2004....
- Neural Analysis of Maternal AggressionSTEPHEN GAMMIE; Fiscal Year: 2006..Basic research into sex differences in aggression, then, is important to understanding the biological underpinnings of sex and gender differences in social behavior, health, and disease. ..
- HORMONES AND BEHAVIORAL DEVELOPMENTBRUCE CUSHING; Fiscal Year: 2004....
- Prenatal Corticosteroid Impact on HippocampusLIBOR VELISEK; Fiscal Year: 2004..The data of this proposal will be critical for determining long-term adverse effects of multiple course prenatal corticosteroid therapy and for the ameliorating these effects in the offspring. ..
- Does Nasal Stimulation Activate Presympathetic Neurons?Paul McCulloch; Fiscal Year: 2005..As such, this research has implications for understanding the etiology of neurogenic hypertension. ..
- Neural basis of learned food aversion and nauseaCHARLES HORN; Fiscal Year: 2009..Effective treatment of nausea may substantially improve the quality of life for patients with chronic disease. ..
- ELEMENTARY SCHOOL NEUROSCIENCE LITERACYGary Duncan; Fiscal Year: 2006..unreadable] [unreadable]..
- Antipsychotic Actions in Models of NMDA HypofunctionGary Duncan; Fiscal Year: 2007..unreadable] [unreadable]..
- The Status and Future of Acupuncture Research: 10 Years Post-NIH Consensus ConferLixing Lao; Fiscal Year: 2007..The proposed conference will do so. [unreadable] [unreadable] [unreadable] [unreadable]..
- CENTRAL CONTROL OF OXYTOCIN RELEASE DURING GESTATIONSTEVEN BEALER; Fiscal Year: 2008..abstract_text> ..
- Hindbrain Mechanisms of Hypoglycemia UnawarenessW Ritter; Fiscal Year: 2007..abstract_text> ..
- Fra-1: A new target for a genomic breast cancer vaccineRalph Reisfeld; Fiscal Year: 2009..This allows for this vaccine to go full circle in evaluation from bench to bedside and back for further improvement. ..
- Neurocircuitry of Illness Induced Behavioral DepressionLISA GOEHLER; Fiscal Year: 2009....
- Muller glia and neuronal regeneration in the retinaAndy Fischer; Fiscal Year: 2009..This information could be applied to not only stimulate neural regeneration to treat sight-threatening diseases of the retina, but also to control gliosis that may be detrimental to the pathogenesis of retinal disorders. ..
- COCAINE REGULATION OF FOSB SPLICINGJudith Potashkin; Fiscal Year: 2004..Because dFosB is also induced by chronic administration of other drugs of abuse, such as amphetamine, nicotine and opiates, the results obtained in this study may also lead to a better understanding of drug addiction. ..
- CNS AND SALT APPETITEDOUGLAS FITTS; Fiscal Year: 2004..The results will have implications for the central control of blood pressure and endocrine secretions as well as behavior during various challenges to body hydration. ..
- NOVEL STRATEGIES FOR THE IMMUNOTHERAPY OF COLON CANCERRalph Reisfeld; Fiscal Year: 2003..The achievement of this proposal's objectives should lead to the design of effective DNA vaccines based on rational immunological principles that may ultimately lead to the improved treatment of colon cancer. ..
- Neural and Immune Cell Interactions: Two of a KindLISA GOEHLER; Fiscal Year: 2002..Finally, the interactions between immune and neural cells may well be bi-directional, providing a novel mechanism by which neural activity can modulate immune cell functions. ..
- MECHANISMS OF PRENATAL COCAINE AND ETHANOL TOXICITYEllen Mitchell; Fiscal Year: 2003..In addition, we will assess exposed pups for susceptibility to further hypoxia at birth and monitor physiological differences after they reach adulthood. ..
- NEURAL SYSTEMS REGULATING VASOPRESSIN RELEASEJ Cunningham; Fiscal Year: 2002..These experiments will determine critical components of the pathways that allow the cardiovascular system to regulate the central nervous system. ..
- CONTROL OF FEEDING BEHAVIOR--HEPATIC AFFERENT SIGNALINGCHARLES HORN; Fiscal Year: 2002..Results from this project may contribute to a better understanding of metabolic stimuli that are sensed by the nervous system, and may elucidate neural controls that are involved in obesity, anorexia, and diabetes. ..
- The Delayed Effects of Phencyclidine: MechanismsSarah Turgeon; Fiscal Year: 2002..These experiments will begin to identify the mechanisms by which PCP produces schizophrenia-like behaviors in animals, providing insight into potential pathophysiologies underlying schizophrenia in humans. ..
- SEXUAL DIMORPHISM IN SEIZURE CONTROLJANA VELISKOVA; Fiscal Year: 2002..Rats of both sexes and various ages will be used. These studies may lead to the development of new antiepileptic treatments that take into the account sexual age-related differences. ..
- Altered Baroreflex Responses by Dietary SodiumSTEVEN BEALER; Fiscal Year: 2003..The work will be performed in the Department of Physiology, University of Tennessee, Memphis, TN 38163. ..
- Gordon Research Conference on the Chemical SensesSusan Travers; Fiscal Year: 2003..The goal of the 2003 Gordon Conference on the Chemical Senses is to vigorously discuss those new, sometimes controversial ideas and to stimulate further, yet more novel hypotheses. ..
- Trigeminal Autonomic InteractionsPaul McCulloch; Fiscal Year: 2002..Having a better understanding of brainstem cardiorespiratory integration might provide a neurological basis for the etiology of SIDS. ..
- The Psychobiology of Rhythms in Diurnal MammalsLaura Smale; Fiscal Year: 2009..These insights will help us understand and eventually alleviate the myriad medical and behavioral problems faced by shift workers, who represent 16% of Americans ..
- Anatomy and Activation of Nucleus Accumbens CART NeuronsGEORGE HUBERT; Fiscal Year: 2008..This will add to our understanding of the anatomy of drug abuse and to hypothesize treatments to alleviate this major social problem. ..
- Craniofacial Imaging in the 21st CenturySunil Kapila; Fiscal Year: 2002..The meeting will be limited to 300 participants who have a background in imaging. This symposia series will provide momentum to discoveries that will be important to craniofacial sciences and patient care. ..
- Studying coordinated firing in hypothalamic GnRH neuronsKELLY SUTER; Fiscal Year: 2007..This will allow us to determine whether desynchronization of firing is a viable mechanism for changes in GnRH secretion during normal reproduction and in reproductive pathologies. [unreadable] [unreadable]..
- OVARIAN HORMONAL CONTROL OF MEAL SIZENORCROSS GEARY; Fiscal Year: 2008..8) Determine the tonic and phasic effects of estradiol on glutamate synaptogenesis in the brainstem by using immunocytochemical detection of synaptic proteins. [unreadable] [unreadable]..
- NEURAL BASIS OF TASTE ELICITED INGESTION AND REJECTIONJOSEPH TRAVERS; Fiscal Year: 2009..Understanding the neurological basis of the fundamental biological decision ingest or reject food will contribute to the eventual solution of these chronic debilitating disorders. ..
- The Regulatory Role of Spinal Lipoxins in NociceptionLinda Sorkin; Fiscal Year: 2008..The aim of this proposal is to investigate the role of lipoxins in conditions associated with persistent inflammatory pain. [unreadable] [unreadable] [unreadable]..
- HORMONAL REGULATION OF MAP KINASE VIA RAP1 AND B-RAFPhilip J S Stork; Fiscal Year: 2010..We will determine the biochemical basis for this specificity of Rap1 for B-Raf in Specific Aim 3. In this aim, we will also establish novel mouse models to test the hypothesis that B-Raf has irreplaceable functions in vivo. ..
- Controlling the Max NetworkPeter Vogt; Fiscal Year: 2008..The proposed work on stabilizers in the Myc-Max network could open the door to a new way of influencing and directing cell growth. ..
- Molecular Requirements for Recombinant Cytotoxins EfficacyWaldemar Debinski; Fiscal Year: 2010..It is expected that the new information gathered will be invaluable in further molecular design of recombinant anti-cancer cytotoxins. ..
- p27Kip1 and RPE Cell CycleDENNIS DEFOE; Fiscal Year: 2003..The alternative hypothesis that the thickening of the RPE layer is due to an increase in cell size will be examined by morphometric analysis of images obtained by confocal microscopy. ..
- Amygdalar and Thalamic Abnormalities in SchizophreniaSabina Berretta; Fiscal Year: 2002....
- Lower urinary tract dysfunction in Parkinson's diseaseNaoki Yoshimura; Fiscal Year: 2003..This is a high priority in the urologic care of patients with Parkinson's disease. ..
- Axonal Targeting in the Mouse Olfactory BulbErnesto Salcedo; Fiscal Year: 2004..We will also examine the effect that nerve transection has on gene expression. These experiments should significantly further our understanding of axonal targeting in the main olfactory bulb. ..
- HYPOTHALAMIC HYPOCRETIN PATHWAYS MODULATING FEEDINGCATHERINE KOTZ; Fiscal Year: 2004....
- Bladder Pain Gene Therapy with Pro-opiomelanocortin cDNANaoki Yoshimura; Fiscal Year: 2004..This research project is important to provide a solid basis for potential future clinical application. ..
- NF-KB SIGNAL TRANSDUCTION IN BRAIN INJURYKEITH PENNYPACKER; Fiscal Year: 2003..These studies will define the role of NF-kB in the process of brain injury and subsequent repair and regeneration processes. ..
- Cellular and Molecular Mechanisms of REM Sleep ControlJames Quattrochi; Fiscal Year: 2005....
- Molecular Determinants of Compulsive Cocaine-TakingMing Xu; Fiscal Year: 2006....
- Mechanism of Estrogen's Inhibitory Effects on FeedingLISA ECKEL; Fiscal Year: 2004..Because eating disorders are more prevalent in women than in men, this proposal targets an important research question with clear clinical relevance . ..
- MODULATION OF NEUROENDOCRINE FUNCTION IN SEPSISDREW CARLSON; Fiscal Year: 2005..The mechanisms revealed are likely to play a significant role in the suppression of host defense and the onset of septic shock...
- THE ONCOGENICITY OF WINGED HELIX PROTEINSPeter Vogt; Fiscal Year: 2003..The nature of activating mutations, the interactions with the preinitiation complex, and the identity and function of target genes will reveal novel molecular targets for therapeutic intervention. ..
- Development of viscerosensory neural inputs in rat brainThomas Koehnle; Fiscal Year: 2006..The experimental outcomes will significantly enhance our understanding of how these pathways mature, and how they operate in health and disease. [unreadable] [unreadable] [unreadable]..
- Prenatal ethanol, social behavior, and prefrontal cortexDerek Hamilton; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- Role of ASIC3 in the etiology of fibromyalgiaKathleen A Sluka; Fiscal Year: 2010..These studies could lead to peripherally based therapeutic approaches to control pain without undesirable CMS (central nervous system) side effects, including gene therapy. ..
- ELECTROPHYSIOLOGY & PHARMACOLOGY OF SLEEP-WAKEFULNESSMahesh Thakkar; Fiscal Year: 2004..Preliminary data suggest a strong suppressive effect of microdialysis-applied 8-OH-DPAT on state-related discharge activity of the dorsal raphe nucleus, and we will also investigate the effects of 5HT1A antagonists. ..
- OLFACTORY CODINGBurton Slotnick; Fiscal Year: 2003..Behavior tasks will use precision olfactometry. Anterograde transport of horseradish peroxidase will be used to assess connections between the olfactory epithelium and olfactory bulb in experimental rats. ..
- OLFACTORY FUNCTION IN GENE-TARGETED MICEBurton Slotnick; Fiscal Year: 2002..A final report of these studies will incorporate a detailed description of apparatus, methods protocol and files of raw data and summary statistics presented in database and spreadsheet format. ..
- Neurobiology of Joint Manipulation Induced AnalgesiaKathleen Sluka; Fiscal Year: 2003..This information will further assist the clinician in determining the treatment of choice for a particular patient and potentially guide future clinical research. ..
- 2005 Bones & Teeth Gordon ConferenceRene St Arnaud; Fiscal Year: 2005..These funds, if granted, will aid immeasurably in allowing the Gordon Research Conference to fulfill its function to stimulate further creativity in bone, cartilage and tooth research. ..
- NEUROBIOLOGY OF CHRONIC MUSCLE PAINKathleen Sluka; Fiscal Year: 2003..These proposed studies will help in the understanding and thus potential treatment of chronic muscle pain, including such conditions as fibromyalgia, myofascial pain and low back pain. ..
- Retinal Neurons Afferent to the Circadian SystemGARY PICKARD; Fiscal Year: 2005..Understanding the retinal neurons and circuits afferent to the SCN and IGL will aid in our ability to understand and treat these disturbances of phase. ..
- Fibronectin Fragment-Induced Osteolysis Mediated by MMPsSunil Kapila; Fiscal Year: 2009..These studies will provide a fundamental understanding of the basis for bone loss in periodontal disease and other osteolytic diseases. ..