Genomes and Genes
Summary: A family of highly acidic calcium-binding proteins found in large concentration in the brain and believed to be glial in origin. They are also found in other organs in the body. They have in common the EF-hand motif (EF-HAND MOTIFS) found on a number of calcium binding proteins. The name of this family derives from the property of being soluble in a 100% saturated ammonium sulfate solution.
Publications377 found, 100 shown here
- S100 proteins: structure, functions and pathologyClaus W Heizmann
Department of Pediatrics, Division of Clinical Chemistry and Biochemistry, University of Zurich, Steinwiesstrasse 75, CH 8032 Zurich, Switzerland
Front Biosci 7:d1356-68. 2002b>S100 proteins regulate intracellular processes such as cell growth and motility, cell cycle regulation, transcription and differentiation...
- Regulation of fibrinolysis by S100A10 in vivoAlexi P Surette
Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, NS
Blood 118:3172-81. 2011..These results establish an important role for S100A10 in the regulation of fibrinolysis and angiogenesis in vivo, suggesting S100A10 plays a critical role in endothelial cell function...
- S100 proteins in mouse and man: from evolution to function and pathology (including an update of the nomenclature)Ingo Marenholz
Division of Clinical Chemistry and Biochemistry, Department of Pediatrics, University of Zürich Steinwiesstrasse 75, 8032 Zurich, Switzerland
Biochem Biophys Res Commun 322:1111-22. 2004..Despite their small molecular size and their conserved functional domain of two distinct EF-hands, S100 proteins developed a plethora of tissue-specific intra- and extracellular functions...
- Evidence that fibroblasts derive from epithelium during tissue fibrosisMasayuki Iwano
Department of Medicine, Vanderbilt University, Nashville, Tennessee, USA
J Clin Invest 110:341-50. 2002..As a general mechanism, this change in fate highlights the potential plasticity of differentiated cells in adult tissues under pathologic conditions...
- Functional roles of S100 proteins, calcium-binding proteins of the EF-hand typeR Donato
Section of Anatomy, Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Via del Giochetto, C P 81 Succ 3, 06122, Perugia, Italy
Biochim Biophys Acta 1450:191-231. 1999..Thus, any S100 dimer is suggested to expose two binding surfaces on opposite sides, which renders homodimeric S100 proteins ideal for crossbridging two homologous or heterologous target proteins...
- Antimicrobial psoriasin (S100A7) protects human skin from Escherichia coli infectionRegine Gläser
Clinical Research Unit of the Department of Dermatology, University Hospital Schleswig Holstein, Campus Kiel, Germany
Nat Immunol 6:57-64. 2005..Zn(2+)-saturated psoriasin showed diminished antimicrobial activity, suggesting that Zn(2+) sequestration could be a possible antimicrobial mechanism. Thus, psoriasin may be key to the resistance of skin against E. coli...
- S100B's double life: intracellular regulator and extracellular signalRosario Donato
Department of Experimental Medicine and Biochemical Sciences, Section Anatomy, University of Perugia, Via del Giochetto C P 81 Succ 3, 06122 Perugia, Italy
Biochim Biophys Acta 1793:1008-22. 2009..Future studies using S100B transgenic and S100B null mice might shed more light on the functional role(s) of the protein...
- Functions of S100 proteinsR Donato
Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Via del Giochetto, 06122 Perugia, Italy
Curr Mol Med 13:24-57. 2013..b>S100 proteins are only expressed in vertebrates and show cell-specific expression patterns...
- RAGE signaling sustains inflammation and promotes tumor developmentChristoffer Gebhardt
Division of Signal Transduction and Growth Control, German Cancer Research Center, 69120 Heidelberg, Germany
J Exp Med 205:275-85. 2008..We show that RAGE signaling drives the strength and maintenance of an inflammatory reaction during tumor promotion and provide direct genetic evidence for a novel role for RAGE in linking chronic inflammation and cancer...
- Expression of S100 proteins in normal human tissues and common cancers using tissue microarrays: S100A6, S100A8, S100A9 and S100A11 are all overexpressed in common cancersS S Cross
Academic Unit of Pathology, Division of Genomic Medicine, School of Medicine and Biomedical Sciences, University of Sheffield, Sheffield, UK
Histopathology 46:256-69. 2005..S100A6, S100A8, S100A9 and S100A11 have all been suggested to have potential roles in carcinogenesis and tumour progression but their expression has not been described in a wide range of human tissues and tumours...
- An annexin 2 phosphorylation switch mediates p11-dependent translocation of annexin 2 to the cell surfaceArunkumar B Deora
Department of Cell and Developmental Biology, Weill Medical College of Cornell University, New York, New York 10021, USA
J Biol Chem 279:43411-8. 2004..Translocation of annexin 2 to the cell surface dramatically increases tissue plasminogen activator-dependent plasminogen activation potential and may represent a novel stress-induced protein secretion pathway...
- S100A10, annexin A2, and annexin a2 heterotetramer as candidate plasminogen receptorsMijung Kwon
Department of Biochemistry, Faculty of Medicine, University of Calgary, 3330 Hospital Drive N W, Calgary, Alberta T2N 4N1, Canada
Front Biosci 10:300-25. 2005..This review highlights the important part that S100A10 plays in plasmin regulation and the role this protein plays in cancer cell invasiveness and metastasis...
- Binding of S100 proteins to RAGE: an updateEstelle Leclerc
Department of Chemistry and Biochemistry, Florida Atlantic University, 777 Glades Road, Boca Raton, FL 33431, USA
Biochim Biophys Acta 1793:993-1007. 2009..However, the exact mechanism is unknown. Among RAGE ligands are members of the S100 protein family. S100 proteins are small calcium binding proteins with high structural homology...
- Thrombin induces endothelial cell-surface exposure of the plasminogen receptor annexin 2Erica A Peterson
Canadian Blood Services, R and D Department, 1800 Alta Vista Drive, Ottawa, ON K1G 4J5, Canada
J Cell Sci 116:2399-408. 2003..These data suggest a novel mechanism that links the coagulation and fibrinolysis pathways by thrombin-mediated feedback...
- Regulation of S100A10 by the PML-RAR-α oncoproteinPaul A O'Connell
Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, NS, USA
Blood 117:4095-105. 2011..These experiments show that S100A10 plays a crucial role in the generation of plasmin leading to fibrinolysis, thus providing a link to the clinical hemorrhagic phenotype of APL...
- Endothelial cell annexin A2 regulates polyubiquitination and degradation of its binding partner S100A10/p11Kai Li He
Department of Cell and Developmental Biology, Weill Cornell Medical College, New York, New York 10065, USA
J Biol Chem 283:19192-200. 2008..This mechanism prevents accumulation of free p11 in the endothelial cell and suggests that regulation of tPA-dependent cell surface fibrinolytic activity is precisely tuned to the intracellular level of p11...
- S100A6 - new facts and featuresWiesława Leśniak
Department of Molecular and Cellular Neurobiology, Nencki Institute of Experimental Biology, 02 093 Warsaw, Poland
Biochem Biophys Res Commun 390:1087-92. 2009..Additionally, S100A6 might have some extracellular activities. This review presents new facts and features concerning the S100A6 protein...
- Mts1 regulates the assembly of nonmuscle myosin-IIAZhong hua Li
Department of Biochemistry, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA
Biochemistry 42:14258-66. 2003..Altogether, these observations are consistent with mts1 regulating myosin IIA assembly by monomer sequestration and suggest that mts1 regulates cell shape and motility through the modulation of myosin-IIA function...
- Structure of the S100A6 complex with a fragment from the C-terminal domain of Siah-1 interacting protein: a novel mode for S100 protein target recognitionYoung Tae Lee
Departments of Biochemistry and Chemistry and Center for Structural Biology, Vanderbilt University, Nashville, Tennessee 37232 8725, USA
Biochemistry 47:10921-32. 2008..A series of structure-based SIP mutations showed reduced S100A6 binding affinity, setting the stage for direct functional analysis of S100A6-SIP interactions...
- The metastasis-associated gene S100A4 is a novel target of beta-catenin/T-cell factor signaling in colon cancerUlrike Stein
Department of Surgery and Surgical Oncology, Robert Rössle Cancer Hospital, Charite Campus Buch, Berlin, Germany
Gastroenterology 131:1486-500. 2006..Our aim was to elucidate the impact of gain-of-function beta-catenin on the metastasis-associated gene S100A4 in human colon cancer cell lines and tumors...
- S100A4, a mediator of metastasisSarah C Garrett
Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York 10461, USA
J Biol Chem 281:677-80. 2006
- S100A10 regulates plasminogen-dependent macrophage invasionPaul A O'Connell
Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, Nova Scotia, Canada
Blood 116:1136-46. 2010..This study establishes a direct involvement of S100A10 in macrophage recruitment in response to inflammatory stimuli...
- S100A4/Mts1 produces murine pulmonary artery changes resembling plexogenic arteriopathy and is increased in human plexogenic arteriopathySteven Greenway
Division of Cardiovascular Research, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
Am J Pathol 164:253-62. 2004..The relationship of increased S100A4/Mts1 to pathologically similar lesions in the transgenic mice and patients occurs despite differences in localization (endothelial versus smooth muscle cells)...
- Functional expression of the epithelial Ca(2+) channels (TRPV5 and TRPV6) requires association of the S100A10-annexin 2 complexStan F J van de Graaf
Department of Cell Physiology, Nijmegen Center for Molecular Life Sciences, University Medical Center Nijmegen, PO Box 9101, NL 6500 HB Nijmegen, The Netherlands
EMBO J 22:1478-87. 2003..In conclusion, the S100A10-annexin 2 complex plays a crucial role in routing of TRPV5 and TRPV6 to plasma membrane...
- S-100B and neuron-specific enolase in serum of mild traumatic brain injury patients. A comparison with health controlsJ R de Kruijk
Neurology Dept University Hospital Maastricht, The Netherlands
Acta Neurol Scand 103:175-9. 2001..The aim of the study was to determine whether serum concentrations of neuron-specific enolase (NSE) and S100-B in mild traumatic brain injury (MTBI) patients are higher than in serum of healthy controls...
- Proinflammatory S100 proteins in arthritis and autoimmune diseaseDirk Foell
Interdisciplinary Center for Clinical Research, University of Muenster, Muenster, Germany
Arthritis Rheum 50:3762-71. 2004
- S100A4 accelerates tumorigenesis and invasion of human prostate cancer through the transcriptional regulation of matrix metalloproteinase 9Mohammad Saleem
Department of Dermatology, University of Wisconsin, Madison, WI 53706, USA
Proc Natl Acad Sci U S A 103:14825-30. 2006..We suggest that S100A4 could be used as a biomarker for CaP progression and a novel therapeutic or chemopreventive target for human CaP treatment...
- Inflammation-associated S100 proteins: new mechanisms that regulate functionJesse Goyette
Centre for Infection and Inflammation Research, School of Medical Sciences, University of New South Wales, Sydney, NSW, 2052, Australia
Amino Acids 41:821-42. 2011..Conversely, S100A8 and S100A9 oxidation and S-nitrosylation may have important protective mechanisms in inflammation...
- The S100A8-serum amyloid A3-TLR4 paracrine cascade establishes a pre-metastatic phaseSachie Hiratsuka
Department of Pharmacology, Tokyo Women s Medical University School of Medicine, 8 1 Kawada cho, Shinjuku ku, Tokyo 162 8666, Japan
Nat Cell Biol 10:1349-55. 2008..Thus, blocking SAA3-TLR4 function in the pre-metastatic phase could prove to be an effective strategy for the prevention of pulmonary metastasis...
- S100A10/p11: family, friends and functionsUrsula Rescher
Institute of Medical Biochemistry, Centre for Molecular Biology of Inflammation, University of Muenster, Von Esmarch Str 56, 48149 Muenster, Germany
Pflugers Arch 455:575-82. 2008..In contrast to all other S100 proteins, S100A10 is Ca(2+) insensitive because of amino acid replacements in its Ca(2+)-binding loops that lock the ..
- S100A4 and metastasis: a small actor playing many rolesKjetil Boye
Department of Tumor Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital, N 0310 Oslo, Norway
Am J Pathol 176:528-35. 2010..In this review, we summarize the evidence connecting S100A4 and cancer metastasis and discuss the mechanisms by which S100A4 promotes tumor progression...
- Identification and characterization of a fibroblast marker: FSP1F Strutz
Penn Center for Molecular Studies of Kidney Disease, Department of Medicine, University of Pennsylvania, Philadelphia 19104 6144, USA
J Cell Biol 130:393-405. 1995..Use of the FSP1 marker, therefore, should further facilitate both the in vivo studies of fibrogenesis and the mapping of cell fate among fibroblasts...
- The human epidermal differentiation complex: cornified envelope precursors, S100 proteins and the 'fused genes' familyMagdalini Kypriotou
Laboratory of Cutaneous Biology, Service of Dermatology and Venereology, Beaumont Hospital CHUV, Lausanne, Switzerland
Exp Dermatol 21:643-9. 2012..Here, we review the EDC genes and the progress in this field...
- Receptor for advanced glycation endproducts and atherosclerosis: From basic mechanisms to clinical implicationsGiuseppina Basta
CNR, Institute of Clinical Physiology, San Cataldo Research Area, Via Moruzzi 1, 56124 Pisa, Italy
Atherosclerosis 196:9-21. 2008..In the atherosclerotic milieu, three classes of RAGE ligands, i.e., products of non-enzymatic glycoxidation, S100 proteins and amphoterin, appear to drive receptor-mediated cellular activation and potentially, acceleration of ..
- The crystal structures of human S100A12 in apo form and in complex with zinc: new insights into S100A12 oligomerisationOlga V Moroz
Structural Biology Laboratory, Department of Chemistry, University of York, Heslington, York YO10 5YW, UK
J Mol Biol 391:536-51. 2009..The role of both zinc and calcium in target binding by S100A12 during host-parasite responses is confirmed by experiments with paramyosin from the tropical parasites Onchocerca volvulus and Brugia malayi...
- S100A7 (Psoriasin), highly expressed in ductal carcinoma in situ (DCIS), is regulated by IFN-gamma in mammary epithelial cellsStina Petersson
Department of Clinical Genetics, Sahlgrenska University Hospital, SE 413 45 Goteborg, Sweden
BMC Cancer 7:205. 2007..IFN-gamma also exerts anti-tumor action in a number of tumor cell types, including breast cancer. We therefore examined the effect of IFN-gamma and STAT-signaling on the psoriasin expression...
- The role of S100 genes in breast cancer progressionEadaoin McKiernan
Department of Pathology and Laboratory Medicine, St Vincent s University Hospital, Dublin 4, Ireland
Tumour Biol 32:441-50. 2011..Based on our findings, we conclude that the different S100 genes play varying roles in breast cancer progression. Specific S100 genes are potential targets for the treatment of basal-type breast cancers...
- Serum glial fibrillary acidic protein is a highly specific biomarker for traumatic brain injury in humans compared with S-100B and neuron-specific enolaseMasahiro Honda
Advanced Medical Emergency and Critical Care Center, Yamaguchi University Hospital, Yamaguchi, Japan
J Trauma 69:104-9. 2010..In this study, serum GFAP, S-100B, and neuron-specific enolase (NSE) were compared in the same samples from severe trauma patients to assess their ability to predict abnormalities detectable on head computed tomography (CT)...
- The role of the annexin A2 heterotetramer in vascular fibrinolysisPatricia A Madureira
Department of Biochemistry and Molecular Biology Dalhousie University, Halifax, NS, USA
Blood 118:4789-97. 2011..The AIIt mediated colocalization of the plasminogen activators with plasminogen results in the rapid and localized generation of plasmin to the endothelial cell surface, thereby regulating fibrinolysis...
- Highly homologous hS100A15 and hS100A7 proteins are distinctly expressed in normal breast tissue and breast cancerRonald Wolf
Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 37 Convent Drive, Bethesda, MD 20892 4255, USA
Cancer Lett 277:101-7. 2009..The differential regulation, expression and distribution of hS100A7 and hS100A15 and their reported distinct functions are compelling reasons to discriminate among these proteins in normal breast and breast cancers...
- Flagellin is the principal inducer of the antimicrobial peptide S100A7c (psoriasin) in human epidermal keratinocytes exposed to Escherichia coliArby Abtin
Department of Dermatology, Medical University of Vienna, Waehringer Guertal 18 20, 1090 Vienna, Austria
FASEB J 22:2168-76. 2008..coli supernatant. Taken together, our data demonstrate that bacterial flagellin is essential and sufficient for the induction of S100A7c expression in KCs by E. coli...
- Seizure-promoting effect of blood-brain barrier disruptionNicola Marchi
Cerebrovascular Research Center, Department of Neurological Surgery, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
Epilepsia 48:732-42. 2007..However, evidences also suggest that BBB failure may be an etiological factor contributing to the development of seizures...
- S100B/RAGE-dependent activation of microglia via NF-kappaB and AP-1 Co-regulation of COX-2 expression by S100B, IL-1beta and TNF-alphaRoberta Bianchi
Department of Experimental Medicine and Biochemical Sciences, University of Perugia, C P 81 Succ 3, 06122 Perugia, Italy
Neurobiol Aging 31:665-77. 2010..Given the crucial roles of COX-2, IL-1beta and TNF-alpha in the inflammatory response, we propose that, by engaging RAGE, S100B might play an important role in microglia activation in the course of brain damage...
- Alterations in 5-HT1B receptor function by p11 in depression-like statesPer Svenningsson
Laboratory of Molecular and Cellular Neuroscience, Rockefeller University, New York, NY 10021, USA
Science 311:77-80. 2006..p11 knockout mice exhibit a depression-like phenotype and have reduced responsiveness to 5-HT1B receptor agonists and reduced behavioral reactions to an antidepressant...
- Evidence for a wide extra-astrocytic distribution of S100B in human brainJohann Steiner
Department of Psychiatry, University of Magdeburg, Leipziger Str, 44, D 39120 Magdeburg, Germany
BMC Neurosci 8:2. 2007..However, studies on S100B in the human brain are rare. Thus, the distribution of S100B was studied by immunohistochemistry in adult human brains to evaluate its cell-type specificity...
- The metastasis associated protein S100A4: role in tumour progression and metastasisD M Helfman
Department of Cell Biology and Anatomy, Sylvester Comprehensive Cancer Center, University of Miami School of Medicine, Miami, FL 33136, USA
Br J Cancer 92:1955-8. 2005..Below we discuss its biochemical properties and possible cellular functions in metastasis including cell motility, invasion, apoptosis, angiogenesis and differentiation...
- Pathologies involving the S100 proteins and RAGEC W Heizmann
Division of Clinical Chemistry and Biochemistry, Department of Pediatrics, University of Zurich, Switzerland
Subcell Biochem 45:93-138. 2007The S100 proteins are exclusively expressed in vertebrates and are the largest subgroup within the superfamily of EF-hand Ca2(+)-binding proteins Generally, S100 proteins are organized as tight homodimers (some as heterodimers)...
- S100 proteins in the epidermisRichard L Eckert
Department of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
J Invest Dermatol 123:23-33. 2004The S100 proteins comprise a family of 21 low molecular weight (9-13 kDa) proteins that are characterized by the presence of two calcium-binding EF-hand motifs...
- RAGE mediates a novel proinflammatory axis: a central cell surface receptor for S100/calgranulin polypeptidesM A Hofmann
College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
Cell 97:889-901. 1999..These data highlight a novel paradigm in inflammation and identify roles for EN-RAGEs and RAGE in chronic cellular activation and tissue injury...
- RAGE: a single receptor for several ligands and different cellular responses: the case of certain S100 proteinsRosario Donato
Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Via del Giochetto, 06122 Perugia, Italy
Curr Mol Med 7:711-24. 2007..b>S100 proteins are expressed in vertebrates exclusively, display a cell-specific distribution, and regulate a large variety ..
- S100B protein in neurodegenerative disordersJohann Steiner
Department of Psychiatry, University of Magdeburg, Magdeburg, Germany
Clin Chem Lab Med 49:409-24. 2011..Moreover, there is no consistent evidence for a correlation between disease severity and concentrations of S100B in CSF or serum. Therefore, S100B has limited usefulness for monitoring disease progression...
- S100A7 enhances mammary tumorigenesis through upregulation of inflammatory pathwaysMohd W Nasser
Department of Pathology, The Ohio State University, Columbus, Ohio 43210, USA
Cancer Res 72:604-15. 2012..In summary, our work used a powerful new model system to show that S100A7 enhances breast tumor growth and metastasis by activating proinflammatory and metastatic pathways...
- Human S100A12: a novel key player in inflammation?Jens Pietzsch
Department of Radiopharmaceutical Biology, Institute of Radiopharmacy, Research Center Dresden Rossendorf, POB 51 01 19, 01314 Dresden, Germany
Amino Acids 36:381-9. 2009..Recent clinical evidence suggests a high potential of S100A12 as a sensitive and specific diagnostic marker of localized inflammatory processes...
- Silencing of the annexin II gene down-regulates the levels of S100A10, c-Myc, and plasmin and inhibits breast cancer cell proliferation and invasionJian Zhang
Department of Orthopedics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China
Saudi Med J 31:374-81. 2010..To explore the roles of annexin II in breast cancer progression, and to study the effect of annexin II on breast cancer cell proliferation and invasion...
- The Ca2+-binding proteins S100A8 and S100A9 are encoded by novel injury-regulated genesI S Thorey
Institute of Cell Biology, , , , Switzerland
J Biol Chem 276:35818-25. 2001....
- Enhanced expression and secretion of antimicrobial peptides in atopic dermatitis and after superficial skin injuryJurgen Harder
Department of Dermatology, Allergology, and Venerology, University Hospital Schleswig Holstein, Campus Kiel, Kiel, Germany
J Invest Dermatol 130:1355-64. 2010..Thus, a disturbed skin barrier may trigger AMP induction in AD and psoriasis. The functional role of AMP in AD, especially with regard to the control of S. aureus colonization, needs further analysis...
- Effects of head and extracranial injuries on serum protein S100B levels in trauma patientsOlli Savola
Department of Neurology, Oulu University Hospital, Oulu, Finland
J Trauma 56:1229-34; discussion 1234. 2004..Serum protein S100B determinations have been recently suggested as markers of traumatic brain injury. However, little is known about the effects of extracranial injuries on S100B levels in trauma patients...
- S100A7 and the progression of breast cancerEthan D Emberley
Manitoba Institute of Cell Biology, University of Manitoba, Winnipeg, Canada
Breast Cancer Res 6:153-9. 2004..Subsequent studies have started to describe a functional role for these S100 proteins as well as their mechanism of action and the biochemical pathways they modify...
- p11, an annexin II subunit, an auxiliary protein associated with the background K+ channel, TASK-1Christophe Girard
Institut de Pharmacologie Moleculaire et Cellulaire, CNRS UMR 6097, 660 route des Lucioles, Sophia Antipolis, 06560 Valbonne, France
EMBO J 21:4439-48. 2002..p11 association with the TASK-1 channel masks an endoplasmic reticulum retention signal identified as Lys-Arg-Arg that precedes the Ser-Ser-Val sequence...
- The temporal profile of inflammatory markers and mediators in blood after acute ischemic stroke differs depending on stroke outcomeH Worthmann
Department of Neurology, Medical School of Hannover, Hannover, Germany
Cerebrovasc Dis 30:85-92. 2010..The present study aimed to clarify the temporal dynamics of discrete inflammatory markers/mediators for future mechanism-targeting anti-inflammatory strategies in ischemic brain damage...
- Differential expression of S100A2 and S100A4 during progression of human prostate adenocarcinomaSanjay Gupta
Department of Urology, Case Western Reserve University and The Research Institute of University Hospitals of Cleveland, Cleveland, OH, USA
J Clin Oncol 21:106-12. 2003..To establish the clinical significance of calcium binding proteins S100A2 and S100A4 during progression of human prostate adenocarcinoma...
- S100A8 and S100A9 mediate endotoxin-induced cardiomyocyte dysfunction via the receptor for advanced glycation end productsJohn H Boyd
Critical Care Research Laboratories, St Paul Hospital, University of British Columbia, Vancouver, Canada
Circ Res 102:1239-46. 2008..This finding provides a novel mechanistic link between circulating pathogen-associated molecular products and subsequent cardiac dysfunction...
- Ca2+/S100 proteins act as upstream regulators of the chaperone-associated ubiquitin ligase CHIP (C terminus of Hsc70-interacting protein)Seiko Shimamoto
Department of Signal Transduction Sciences, Kagawa University Faculty of Medicine, 1750 1 Ikenobe, Miki cho, Kita gun, Kagawa, Japan
J Biol Chem 288:7158-68. 2013..We previously reported that Ca(2+)/S100 proteins directly associate with the TPR proteins, such as Hsp70/Hsp90-organizing protein (Hop), kinesin light chain, ..
- Regulation of S100A8 by glucocorticoidsKenneth Hsu
Inflammatory Diseases Research Unit, School of Medical Sciences, University of New South Wales, Sydney, New South Wales, Australia
J Immunol 174:2318-26. 2005..Results support the proposal that A8 has anti-inflammatory properties that may be independent of hetero-complex formation with A9 and may also enable localized defense in the absence of overriding deleterious host responses...
- Phagocyte-specific S100 proteins and high-sensitivity C reactive protein as biomarkers for a risk-adapted treatment to maintain remission in juvenile idiopathic arthritis: a comparative studyJoachim Gerss
Institute of Biostatistics and Clinical Research, University of Muenster, Muenster, Germany
Ann Rheum Dis 71:1991-7. 2012..The present study investigated whether patients with JIA at risk of relapse can be identified by biomarkers even if clinical signs of disease activity are absent...
- Increased S100A4 expression combined with decreased E-cadherin expression predicts a poor outcome of patients with pancreatic cancerYasuhisa Oida
Department of Surgery, Tokai University School of Medicine, Kanagawa 259 1193, Japan
Oncol Rep 16:457-63. 2006..The combined examination of these two molecules is useful in evaluating the outcome of pancreatic cancer patient...
- Peripheral detection of S100beta during cardiothoracic surgery: what are we really measuring?Vincent Fazio
Cerebrovascular Research Center, The Cleveland Clinic Foundation, Ohio 44195, USA
Ann Thorac Surg 78:46-52; discussion 52-3. 2004..Objectives of this study were (1) to quantify S100 beta levels in serum and pericardial cavity during coronary artery bypass grafting (CABG), and (2) to identify proteins recognized by standard immunodetection as S100beta...
- S100A4 mediates endometrial cancer invasion and is a target of TGF-beta1 signalingRan Xie
Department of Pathology, University of Texas M D Anderson Cancer Center, Houston, TX, USA
Lab Invest 89:937-47. 2009..These results also suggest that endometrial cancer cell invasion and fibrosis share common molecular mechanisms...
- Suppression of experimental autoimmune encephalomyelitis by selective blockade of encephalitogenic T-cell infiltration of the central nervous systemShirley ShiDu Yan
Department of Pathology, College of Physicians and Surgeons of Columbia University, New York, New York, USA
Nat Med 9:287-93. 2003..These data reinforce the importance of RAGE-ligand interactions in modulating properties of CD4+ T cells that infiltrate the CNS...
- Memory impairment correlates with increased S100B serum concentrations in patients with chronic schizophreniaAnya Pedersen
University Medical Faculty, Department of Psychiatry, 48149 Munster, Germany
Prog Neuropsychopharmacol Biol Psychiatry 32:1789-92. 2008..The findings support the hypothesis that astrocyte activation might contribute to the development of cognitive dysfunction in schizophrenia...
- Both Ca2+ and Zn2+ are essential for S100A12 protein oligomerization and functionOlga V Moroz
Wolfson Centre for Age Related Diseases, School of Biomedical and Health Sciences, King s College London, London, UK
BMC Biochem 10:11. 2009..S100A12 is an important factor in host/parasite defenses and in the inflammatory response. Like several other S100 proteins, it binds zinc and copper in addition to calcium...
- Glial and neuronal proteins in serum predict outcome after severe traumatic brain injuryP E Vos
Department of Neurology, University Medical Centre Nijmegen, The Netherlands
Neurology 62:1303-10. 2004..To study the ability of glial (glial fibrillary acidic protein [GFAP] and S100b) and neuronal (neuron specific enolase [NSE]) protein levels in peripheral blood to predict outcome after severe traumatic brain injury...
- Fecal S100A12: a novel noninvasive marker in children with Crohn's diseaseNaomi S H de Jong
School of Women s and Children s Health, University of New South Wales, Australia
Inflamm Bowel Dis 12:566-72. 2006....
- Potential inflammatory biomarkers in Alzheimer's diseaseRobert E Mrak
Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
J Alzheimers Dis 8:369-75. 2005....
- Overexpression of protein S100A4 is independently associated with overall survival in stage C colonic cancer but only in cytoplasm at the advancing tumour frontP S S Kho
Department of Medicine, Concord Hospital, Sydney, New South Wales, Australia
Int J Colorectal Dis 27:1409-17. 2012..This study investigated the association between S100A4 and overall survival and other clinicopathological features in patients with stage C colonic cancer...
- S100B gene polymorphisms predict prefrontal spatial function in both schizophrenia patients and healthy individualsJinguo Zhai
School of Mental Health, Jining Medical University, 45 Jianshe South Road, Jining 272013, Shandong Province, PR China
Schizophr Res 134:89-94. 2012..No SNP was associated with prefontal functions in the verbal domain (all Ps >0.05). These results extend our previous study and further confirm the important roles of the S100B gene in spatial abilities...
- S100A expression in normal corneal-limbal epithelial cells and ocular surface squamous cell carcinoma tissueJing Li
Department of Ophthalmology, Xinhua Hospital, Shanghai Jiao Tong University, China
Mol Vis 17:2263-71. 2011..To study the expression and cellular distribution of multiple S100A genes and proteins in normal corneal-limbal epithelium and ocular surface squamous cell carcinoma (SCC) tissue...
- BRCA1 and c-Myc associate to transcriptionally repress psoriasin, a DNA damage-inducible geneRichard D Kennedy
Cancer Research Centre, Queen s University Belfast, Belfast City Hospital, Belfast, United Kingdom
Cancer Res 65:10265-72. 2005..Therefore, we identified a novel transcriptional mechanism that is likely to contribute to BRCA1-mediated resistance to etoposide...
- Phosphoinositide specificity of and mechanism of lipid domain formation by annexin A2-p11 heterotetramerNikhil A Gokhale
Department of Chemistry, University of Illinois, Chicago, Illinois 60607 7061, USA
J Biol Chem 280:42831-40. 2005..Collectively, these studies elucidate the structural determinant of the PtdIns(4,5)P2 selectivity of A2t and suggest that A2t may be involved in the regulation of PtdIns(4,5)P2 clustering in the cell...
- S100A7, S100A10, and S100A11 are transglutaminase substratesM Ruse
Department of Physiology and Biophysics, Case Western Reserve University School of Medicine, 2109 Adelbert Road, Cleveland, Ohio 44106 4970, USA
Biochemistry 40:3167-73. 2001b>S100 proteins are a family of 10-14 kDa EF-hand-containing calcium binding proteins that function to transmit calcium-dependent cell regulatory signals...
- The metastasis associated protein S100A4: a potential novel link to inflammation and consequent aggressive behaviour of rheumatoid arthritis synovial fibroblastsL Oslejsková
Institute of Rheumatology, 1st Medical Faculty, Charles University, Prague, Czech Republic
Ann Rheum Dis 67:1499-504. 2008....
- Risk variants in the S100B gene, associated with elevated S100B levels, are also associated with visuospatial disability of schizophreniaJinguo Zhai
School of Mental Health, Jining Medical University, Jining 272013, Shandong Province, People s Republic of China
Behav Brain Res 217:363-8. 2011..These results implicate a role for S100B gene polymorphisms in the cognitive functions of schizophrenia patients and encourage further investigation into spatial disability as an endophenotype of schizophrenia...
- S100B and NSE serum levels in obstructive sleep apnea syndromeCarla W Braga
Departamento de Bioquimica, Rua Ramiro Barcelos 2600 anexo, Universidade Federal do Rio Grande do Sul, 90035 003 Porto Alegre, RS, Brazil
Sleep Med 7:431-5. 2006..In the present work we measured the serum levels of S100B and NSE in order to evaluate the deleterious effects of OSAS to the brain...
- Spatial and temporal expression of S100B in cells of oligodendrocyte lineageS Hachem
Unité INSERM 469, Centre CNRS INSERM de Pharmacologie et d Endocrinologie, Montpellier Cedex, France
Glia 51:81-97. 2005....
- Carboxylated N-glycans on RAGE promote S100A12 binding and signalingGeetha Srikrishna
Sanford Children s Health Research Center, Sanford Burnham Medical Research Institute, La Jolla, California 92037, USA
J Cell Biochem 110:645-59. 2010..These results demonstrate that carboxylated N-glycans on RAGE enhance binding potential and promote receptor clustering and subsequent signaling events following oligomeric S100A12 binding...
- The 1.5 Å crystal structure of human receptor for advanced glycation endproducts (RAGE) ectodomains reveals unique features determining ligand bindingHaJeung Park
Laboratory of Structural Biology, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
J Biol Chem 285:40762-70. 2010..of the pattern recognition receptor, RAGE with key ligands such as advanced glycation end products (AGE), S100 proteins, amyloid β, and HMGB1 has been linked to diabetic complications, inflammatory and neurodegenerative disorders,..
- Brain- and heart-type fatty acid-binding proteins in the brain: tissue distribution and clinical utilityMaurice M A L Pelsers
Department of Molecular Genetics, Cardiovascular Research Institute Maastricht, Maastricht University, The Netherlands
Clin Chem 50:1568-75. 2004..We investigated the tissue distribution of brain- and heart-type fatty acid-binding proteins (B-FABP and H-FABP) in segments of the human brain and the potential of either protein to serve as plasma marker for diagnosis of brain injury...
- S100A4 expression is associated with lymph node metastasis in papillary microcarcinoma of the thyroidHye Sook Min
Department of Pathology, National Cancer Center, Goyang, Gyenggi, Korea
Mod Pathol 21:748-55. 2008..In conclusion, S100A4 expression in papillary microcarcinomas may indicate the presence of nodal metastasis. Thus, S100A4 immunohistochemistry may be valuable for predicting metastatic potential in papillary microcarcinomas...
- S100B in schizophrenia: an updateMatthias Rothermundt
Department of Psychiatry, University of Muenster, D 48149 Muenster, Germany
Gen Physiol Biophys 28:F76-81. 2009..These findings suggest that the activation of astrocytes might be an important pathogenic factor for the development of schizophrenia...
- Expression of the calcium-binding protein S100A4 is markedly up-regulated by osmotic stress and is involved in the renal osmoadaptive responseChristopher J Rivard
Division of Renal Diseases and Hypertension, School of Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
J Biol Chem 282:6644-52. 2007..In summary, we describe the heretofore unrecognized up-regulation of a small calcium-binding protein, both in vitro and in vivo, whose absence profoundly delays osmoadaptation and slows cellular growth under hypertonic conditions...
- Nuclear S100A7 is associated with poor prognosis in head and neck cancerSatyendra Chandra Tripathi
Department of Biochemistry, All India Institute of Medical Sciences, New Delhi, India
PLoS ONE 5:e11939. 2010..This study aimed to determine the clinical significance of S100A7 overexpression in HNSCC...
- Phenotypic and functional characteristics of mesenchymal stem cells differentiated along a Schwann cell lineageJenny Caddick
Blond McIndoe Research Laboratories, University of Manchester, Manchester, United Kingdom
Glia 54:840-9. 2006..These findings support the assertion that MSCs can be differentiated into cells that are Schwann cell-like in terms of both phenotype and function...
- Schizophrenia-associated neural growth factors in peripheral blood. A reviewNico J M van Beveren
Erasmus University Medical Center, Department of Psychiatry, Post Box 2040, 3000 CA Rotterdam, The Netherlands
Eur Neuropsychopharmacol 16:469-80. 2006....
- S100A4 is upregulated in injured myocardium and promotes growth and survival of cardiac myocytesMikael Schneider
The Laboratory of Molecular and Cellular Cardiology, The Danish National Research Foundation Centre for Cardiac Arrhythmia, Department of Medicine B, H S Rigshospitalet, Copenhagen University Hospital, Denmark
Cardiovasc Res 75:40-50. 2007..We therefore hypothesized that S100A4 could play a supportive role in the injured heart...
- The value of serum biomarkers in prediction models of outcome after mild traumatic brain injuryJane Topolovec-Vranic
Trauma and Neurosurgery Program, St Michael s Hospital, Toronto, Canada
J Trauma 71:S478-86. 2011..To determine, using a civilian model of mild traumatic brain injury (TBI), the added value of biomarker sampling upon prognostication of outcome at 1 week and 6 weeks postinjury...
- Autoantibodies against amyloid and glial-derived antigens are increased in serum and cerebrospinal fluid of Lewy body-associated dementiasWalter Maetzler
Center of Neurology, Department of Neurodegeneration, Hertie Institute for Clinical Brain Research, University of Tuebingen, Tuebingen, Germany
J Alzheimers Dis 26:171-9. 2011..The potential of neural-derived IgG autoantibodies as part of a biomarker panel for the diagnosis of Lewy body-associated dementias should be further evaluated...
- Advanced glycation end products induce the expression of interleukin-6 and interleukin-8 by receptor for advanced glycation end product-mediated activation of mitogen-activated protein kinases and nuclear factor-κB in human osteoarthritis chondrocytesZafar Rasheed
Department of Medicine, Division of Rheumatology, MetroHealth Medical Center Case Western Reserve University, Hamann Bldg, Suite 586, 2500 Metro Health Drive, Cleveland, OH 44109, USA
Rheumatology (Oxford) 50:838-51. 2011..To investigate whether advanced glycation end products (AGEs) induce the expression of IL-6 and IL-8 through the receptor for AGEs (RAGE)-activated pathways in human OA chondrocytes...
- Can low serum levels of S100B predict normal CT findings after minor head injury in adults?: an evidence-based review and meta-analysisJohan Undén
Department of Anaesthesia and Intensive Care, Halmstad Regional Hospital, Halmstad, Sweden
J Head Trauma Rehabil 25:228-40. 2010..To determine whether low levels of S100B in serum can predict normal computed tomography (CT) findings after minor head injury (MHI) in adults...
- Stable knockdown of S100A4 suppresses cell migration and metastasis of osteosarcomaMasahiko Fujiwara
Department of Human Pathology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
Tumour Biol 32:611-22. 2011....
- The economic impact of S-100B as a pre-head CT screening test on emergency department management of adult patients with mild traumatic brain injuryShuolun Ruan
Department of Community and Preventive Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
J Neurotrauma 26:1655-64. 2009..Despite its high sensitivity and excellent negative predictive value, serum S-100B has low specificity and low positive predictive value, limiting its ability to reduce numbers of CT scans and hospital costs...
- DLC1 interaction with S100A10 mediates inhibition of in vitro cell invasion and tumorigenicity of lung cancer cells through a RhoGAP-independent mechanismXuyu Yang
Laboratory of Experimental Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA
Cancer Res 71:2916-25. 2011..These results suggest that a novel GAP-independent mechanism contributes to the tumor suppressive activity of DLC1, and highlight the importance and complexity of protein-protein interactions involving DLC1 in certain cancers...
- CALCIUM, S100 PROTEINS AND KERATINOCYTE DIFFERENTIATIONRICHARD ECKERT; Fiscal Year: 2004..b>S100 proteins are an important class of protein that are required for calcium signal transduction...
- DAMP-RAGE Signaling and Fetal Injury in Inflammation-Induced Preterm BirthIrina A Buhimschi; Fiscal Year: 2013..This body of knowledge, corroborated with the evidence that HMGB1 and S100 proteins are putative RAGE ligands, has led us to propose an active role for the DAMP- RAGE axis in inducing antenatal ..
- 950 MHz NMR Spectrometer with Cryogenic ProbeDAVID JOSEPH WEBER; Fiscal Year: 2010..Dr. David J. Weber (UMB), Structure/function and inhibition of protein-protein complexes involving S100 proteins;2. Dr. Michael Summers (UMBC) NMR studies of retroviral genome packaging;3. Dr...
- Invivo role of S100A4 in OA pathophysiologyRaghunatha R Yammani; Fiscal Year: 2013..b>S100 proteins are low molecular weight, acidic, calcium-binding proteins that play an important role in various cellular ..
- Epithelial Cell-Derived IL-1-alpha as a Novel Danger Signal in IBD PathogenesisEleni Stylianou; Fiscal Year: 2013..protein 1 (HMGB1), nucleic acids, uric acid, degradation products of the extracellular matrix, calcium-binding S100 proteins, and many others...
- Protein dynamics of calcium-S100A5 in the presence and absence of target peptideMelissa A Liriano; Fiscal Year: 2012..Aberrant levels ofthese signaling molecules have also been associated with various forms of cancer. Some S100 proteins have been found to directly promote the advancement of certain tumors via protein-protein interactions...
- Targeting RAGE/Abeta interaction with single chain monoclonal antibodiesEstelle Leclerc; Fiscal Year: 2012..We will then test the ability of these antibodies to block cell death triggered by the engagement of RAGE by distinct b amyloid oligomeric forms. ..
- S100A8/A9 and carboxylated N-glycans in inflammation-mediated colon cancerGEETHA K SRIKRISHNA; Fiscal Year: 2010..tissues;and Generate bone marrow chimeras to study if S100 deficient mice are more prone to tumors when S100 proteins are restored...
- CLINICAL TRIAL OF HEMATOCRIT STRATEGY IN HEART SURGERYJane Newburger; Fiscal Year: 2004..The inferences reached in this study population should be broadly generalized to infants with other forms of congenital heart disease undergoing early repair and thus should have substantial impact on clinical practice. ..
- Structure-Function Studies of Annexin I and IIHartmut Luecke; Fiscal Year: 2006..5) Co-crystallize annexin with t-PA and solve the structure of this complex after characterizing complex formation in solution. ..
- Chondrocyte S100/Calgranulins and RAGE in OsteoarthritisRobert Terkeltaub; Fiscal Year: 2009..RAGE ligands include calgranulin/S100 proteins that can exert inflammatory cytokine-like effects...
- Structure of calcyclin binding protein-S100A6 complexWalter Chazin; Fiscal Year: 2004DESCRIPTION (provided by applicant) S100 proteins constitute a major subfamily of EF-hand Ca2+-binding proteins that are characterized by cell type-specific expression and unusually high abundance in a variety of disease states, ..
- The Structure and Function of S100 ProteinsDAVID JOSEPH WEBER; Fiscal Year: 2010..but differences in the structures of two proteins in the "hinge" and C-terminal loop explains why these two S100 proteins bind tightly to different protein targets;(ix) together these data enabled us to start developing inhibitors ..
- DECIPHERING THE CELLULAR FUNCTION OF ALDOLASEDEAN TOLAN; Fiscal Year: 2003..to bind to several important intracellular binding targets, such as F-actin and the calcium-binding S100 proteins. Evolutionary comparisons have revealed isozyme-specific residues (ISRs) and this proposal will determine ..
- 600 MHz NMR Spectrometer ConsoleDavid Weber; Fiscal Year: 2007..Dr. David J. Weber (PI), Structure/function and drug design for S100 proteins; 2. Dr. Lindsay Black, Structure/function studies of the phage IPI protein; 3. Dr...
- ATOMIC STRUCTURE OF SMOOTH MUSCLE CALDESMONRoberto Dominguez; Fiscal Year: 2004..including binding to actin, tropomyosin, and Ca2+-dependent regulatory proteins (such as calmodulin and S100 proteins)...
- ROLES OF PHOSPHOLIPID AND CA2+ IN BRAINJYH FA KUO; Fiscal Year: 1990..It is hoped that the proposal will produce new knowledge regarding regulation of brain biology and pathology by phospholipid, Ca2+ and S-100 protein via protein phosphorylation reaction...
- Neuroinflammation in Alzheimers Disease Murine ModelsJeffrey Craft; Fiscal Year: 2007..These mice may then be treated with test compounds to identify and/or verify the neuroinflammatory pathways through which these agents exert their effects. [unreadable] [unreadable]..
- Epidemiology of Traumatic Brain InjuryJeffrey Bazarian; Fiscal Year: 2005....
- Comparative DNA Microarray Analysis of Brain TumorsDaniel Brat; Fiscal Year: 2006....
- Vaso-occlusive Mechanisms that Induce Hypoxia and Cause Glioma Progression.Daniel J Brat; Fiscal Year: 2010..This proposal introduces entirely novel concepts that may explain the highly aggressive properties of GBM and suggests therapeutic approaches that could potentially stabilize its progression. ..
- Drug Discovery Academic Research Experience(DARE)Linda Van Eldik; Fiscal Year: 2006....
- Detecting Axonal Damage After Mild Traumatic Brain InjuryJeffrey Bazarian; Fiscal Year: 2009....
- Mechanisms of myometrial healing and regenerationCatalin Buhimschi; Fiscal Year: 2006....
- Intravascular Thrombosis in GlioblastomaDaniel Brat; Fiscal Year: 2005..Our emerging model represents a paradigm shift in the understanding of GBM and should lead directly to more effective therapies. ..
- Fine Needle Aspiration Biopsy(FNAB) Needle DeviceVinod Shidham; Fiscal Year: 2002..Apart from the worldwide market, the potential market in United States alone should exceed $1,500,000 per year. ..
- Pathogenic Role of Abeta, tau and Inflammation in Inclusion Body MyositisMasashi Kitazawa; Fiscal Year: 2008..Through this application, we hope to advance the understanding of IBM as well as dementias and evaluate potential therapeutic strategies for IBM. [unreadable] [unreadable] [unreadable] [unreadable]..
- Anthrax vaccination by targeting spore germinationChun Ming Huang; Fiscal Year: 2005..This unprecedented study will elicit the pathological mechanisms and vaccination capabilities of immune inhibitor A and camelysin expressed in Bacillus anthracis. ..
- Training Cross-Disciplinary Researchers in DiabetesElizabeth Mellins; Fiscal Year: 2007..Achievement of this goal has the potential to contribute to new diagnostic and therapeutic approaches for diabetes and related conditions. ..
- RAP1A AND RAP1B IN THE DIAGNOSIS AND TMT - ORAL CANCERNISHA D SILVA; Fiscal Year: 2004..The third segment involves the design of a protocol to investigate the use of rap1A in gene therapy to treat residual epithelial dysplasia or squamous cell carcinoma lesions. ..
- ALPHA 2 ADRENERGIC CONTROL IN IRRITABLE BOWEL SYNDROMEMichael Camilleri; Fiscal Year: 2008..Significance: This project will characterize pharmacogenetic mechanisms determining the response to clonidine through studies of candidate genes that control alpha2-adrenoreceptor function and norepinephrine transport in IBS. ..
- ERAB, A BETA, NEUROTOXICITY AND ALZHEIMERS DISEASEShi Du Yan; Fiscal Year: 2003..abstract_text> ..
- RECOVERY OF FUNCTION FOLLOWING NEURAL DAMAGERichard E Zigmond; Fiscal Year: 2010..This proposal focuses on identifying molecules that trigger regeneration with the idea that they might be used to enhance regeneration in the periphery and promote regeneration in the central nervous system. ..
- Summer Training Program in NeuroscienceOswald Steward; Fiscal Year: 2006..Where appropriate, trainees will be encouraged to present their results at national meetings, and support will be provided for students to attend such meetings. [unreadable] [unreadable]..
- Aging and brain 5-lipoxygenaseHari Manev; Fiscal Year: 2010..The proposed experiments may corroborate the hypothesis that epigenetic mechanisms are involved in brain aging. ..
- CYCLIC GMP SIGNALING PATHWAYS IN RETINASITARAMAYYA ARI; Fiscal Year: 2003..Successful completion of the proposed studies will, for the first time, establish the biochemical mechanism of cyclic GMP action in light adaptation, and identify the proteins that mediate its effects. ..
- STRUCTURAL BIOLOGY OF EF-HAND CALCIUM BINDING PROTEINSWalter Chazin; Fiscal Year: 2005..These results will link the large volume of experimental data available on EF-hand proteins, uncover the mechanisms by which these proteins function, and help to define their biological activities. ..
- FGF in sensory system developmentOLIVIA MARY BERMINGHAM MCDONOGH; Fiscal Year: 2010..Moreover, a better understanding of the molecular pathways regulating normal development will be critical for rational strategies for hair cell replacement and regeneration in adult onset deafness. ..
- PKC and Cellular Signaling in the Suicide BrainGhanshyam Pandey; Fiscal Year: 2009..This knowledge may aid in developing better therapeutic strategies for the treatment of suicidal behavior. ..
- TOPICAL RETINOIDS FOR DIABETIC FOOT ULCERSJames Varani; Fiscal Year: 2003..abstract_text> ..
- SQUAMOUS EPITHELIAL CELL INVASION IN ORGAN CULTUREJames Varani; Fiscal Year: 2001..abstract_text> ..
- Axon Regeneration after Spinal Cord Injury in MiceOswald Steward; Fiscal Year: 2009..Together, these studies will provide a critical data base regarding the growth capacity of cortico-spinal tract axons in mice, which will be essential for future studies involving genetically modified mice. ..
- Epigenetics of fetal alcohol syndromeFeng Zhou; Fiscal Year: 2009..The effect of these epigenetic key genes will be confirmed in the in vivo model exposed to alcohol vapor chamber with alcohol exposure pattern and paradigms similar to the whole embryonic culture. ..
- ALCOHOL & BRAIN DEVELOPMENT: MIDLINE CASCADE HYPOTHESISFeng Zhou; Fiscal Year: 2003....
- Proteomics: The Next Grand Biological ChallengeWalter Chazin; Fiscal Year: 2002..A concentrated effort will be made to attract ethnic minorities, women and persons with disabilities as participants, organizers, and speakers. ..
- APOLIPOPROTEIN E EFFECT ON THE CNS IMMUNE RESPONSEDaniel Laskowitz; Fiscal Year: 2002..abstract_text> ..
- GENETIC APPROACH TO CNS REGENERATION RESEARCHOswald Steward; Fiscal Year: 2001....
- PI and Wnt Signaling in Postmortem Brain of Biopolar and Schizophrenia SubjectsGhanshyam N Pandey; Fiscal Year: 2011..This may eventually lead to i better understanding of the pathophysiology of BP or SZ illnesses and may aid in the development of more appropriate therapeutic agents for the treatment of these disorders. ..
- S100 PROTEINS: STRUCTURAL BASIS OF FUNCTIONAL PROPERTIESWalter Chazin; Fiscal Year: 2009..This proposal is aimed at understanding how S100 proteins modulate the activities of their binding partners and participate in signal transduction pathways, by studying ..
- Trigeminal Neuropathic Pain MechanismsMichael Henry; Fiscal Year: 2006..Identification of specific sodium channel alterations after injury may help develop more selective treatments for neuropathic pain. ..
- Amphiregulin in Psoriatic Epidermal HyperplasiaJAMES TILFORD ELDER; Fiscal Year: 2010..If successful, this research will have important public health consequences not only in psoriasis but also in a wide variety of dermatoses characterized by epidermal hyperplasia. ..
- Evaluation of pH Dependent Neuroprotectants in SAH ModelDaniel Laskowitz; Fiscal Year: 2008..In this project promising new drugs that may one day protect brain tissue from damage caused by SAH and stroke will be tested in an animal model of ischemia. [unreadable] [unreadable] [unreadable]..
- BHLH FACTOR IN DIABETES & PANCREAS DEVELOPMENTDEBRA BRAMBLETT; Fiscal Year: 2003..The BETA4 knockout will be a mouse model system for the study of aspects of pancreas development and possibly pancreatic disease. ..
- Rap 1-Mediated Protein Transport in Oral CancerNISHA D SILVA; Fiscal Year: 2006..The significance of this research is that it explores an important and novel mechanism for nucleocytoplasmic transport of pro-proliferative proteins in oral cancer, thereby identifying novel treatment targets. [unreadable] [unreadable]..
- ApoE-mimetic peptides protect against brain injuryDaniel Laskowitz; Fiscal Year: 2004..We will use this system to investigate possible pharmacogenomic interactions between the therapeutic apoE peptide and the humanized apoE background in the targeted replacement mice. ..
- Proteomics of Idiopathic Pulmonary FibrosisNaftali Kaminski; Fiscal Year: 2006..We assume that this approach will provide us with new molecular targets for therapeutic intervention in pulmonary fibrosis. ..
- Proposed Role for Neuronal Serotonin N-acetyltransferaseHari Manev; Fiscal Year: 2006..We expect the results to elucidate the role of AANAT/NAS in neuronal functioning, and in the long term, in the pathobiology of depression. ..
- The Effects of Resveratrol on PresbyacusisMichael Seidman; Fiscal Year: 2004..Furthermore, these data will provide novel strategies to impart greater wellness in the elderly population and perhaps have a positive effect on health care expenses. ..
- CYTOKINES, NEURODEGENERATION AND DOWN'S SYNDROMESue Griffin; Fiscal Year: 2004..Accomplishment of our aims will elucidate the pathogenic mechanisms underlying the cognitive decline apparent at middle age in Down's patients and provide targets for possible therapeutic intervention. ..
- Alcohol and SIV neuroinvasion in vivo and in vitroANDREW MACLEAN; Fiscal Year: 2004..This proposal combines in vitro and in vivo models and expertise in the neuropathogenesis of AIDS of the SIV macaque model with expertise in the biological effects of alcohol abuse. ..
- BIOCHEMICAL MECHANISMS OF BRAIN INJURYEARL ELLIS; Fiscal Year: 2006..Aims and Methods: Our approach will use astrocytes and neuronal plus glial cultures, Fura-2 measurement. ..
- PHTHALOCYANINE PDT--IN VIVO RESPONSES AND MECHANISMSCraig Elmets; Fiscal Year: 2004..The long-term goal of these studies is to generate new knowledge regarding the in vivo mechanisms by which PDT works so that it can be used more effectively to treat cancer. ..
- New Molecular Targets in Pulmonary FibrosisNaftali Kaminski; Fiscal Year: 2006..This will be done by assessing the effect of in-vitro inhibiting or inducing the expression of validated candidate molecules on ECM production and cytokine and growth factor secretion. ..
- Secretomes captured in vivo via ultrafiltration probesChun Ming Huang; Fiscal Year: 2008..We believe that using CUF probes/Mass spectrometry will be a powerful tool which can be applied to other animal models and other human diseases. [unreadable] [unreadable] [unreadable]..
- MOLECULAR BASIS OF LOCAL ANESTHESIAWalter Chazin; Fiscal Year: 2008....
- Ultrasensitive FACTT assays for serum biomarkersXiaowei Xu; Fiscal Year: 2008..unreadable] [unreadable] ASSESSMENT: [unreadable] [unreadable] [unreadable]..
- MATERNAL ALCOHOLISM AND CNS DEVELOPMENT IN OFFSPRINGMARY DRUSE MANTEUFFEL; Fiscal Year: 2007..Analyses will include western blot analyses, real-time quantitative RT-PCR, fluorescence and light microscopy, immunohistochemistry, and enzyme assays. ..
- ADENOSINE AND TRAUMATIC BRAIN INJURYPatrick Kochanek; Fiscal Year: 2007..These studies explore the most promising adenosine-based therapy for TBI-A2a receptor antagonists. Our bench to bedside track record ensures translation to the clinic. [unreadable] [unreadable]..
- Bevacizumab and radiation therapy for sarcomasSam Yoon; Fiscal Year: 2007..This study explores a novel combination of the anti-angiogenic agent bevacizumab and radiation therapy for the treatment of STS. [unreadable] [unreadable] [unreadable]..
- MICROGLIAL NEURON SPECIFIC TOXINDaniel Laskowitz; Fiscal Year: 2003..Conversely, drugs that show promise against AD and PD will be examined in this model system to see if they inhibit the production or action of the neuron- specific toxin. ..
- Focal Brain Ischemia in the TNF-alpha-Transgenic RatL Pettigrew; Fiscal Year: 2007....
- The Role of RAGE and EAEShi Du Yan; Fiscal Year: 2005....