wt1 proteins

Summary

Summary: Isoforms encoded by the WT1 Wilms tumor suppressor gene (GENES, WILMS TUMOR) and produced by alternative splicings. They are zinc finger-containing transcription factors involved in both transactivation and repression, and are critical for normal development and function of the urogenital tract.

Top Publications

  1. pmc Wt1 is required for cardiovascular progenitor cell formation through transcriptional control of Snail and E-cadherin
    Ofelia M Martinez-Estrada
    MRC Human Genetics Unit and Institute for Genetics and Molecular Medicine, Edinburgh, UK
    Nat Genet 42:89-93. 2010
  2. pmc Epicardial progenitors contribute to the cardiomyocyte lineage in the developing heart
    Bin Zhou
    Harvard Stem Cell Institute and Department of Cardiology, Children s Hospital Boston, 300 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nature 454:109-13. 2008
  3. ncbi The serosal mesothelium is a major source of smooth muscle cells of the gut vasculature
    Bettina Wilm
    Stahlman Cardiovascular Laboratories, Department of Medicine and Program for Developmental Biology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Development 132:5317-28. 2005
  4. pmc Vaccination with synthetic analog peptides derived from WT1 oncoprotein induces T-cell responses in patients with complete remission from acute myeloid leukemia
    Peter G Maslak
    Leukemia Service, Department of Medicine, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA
    Blood 116:171-9. 2010
  5. pmc The Wilms tumor gene, Wt1, is required for Sox9 expression and maintenance of tubular architecture in the developing testis
    Fei Gao
    Department of Molecular Genetics Cancer Genetics, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 103:11987-92. 2006
  6. ncbi WT1 proteins: functions in growth and differentiation
    V Scharnhorst
    Department of Molecular and Cellular Biology and Center for Biomedical Genetics, Leiden University Medical Center, Wassenaarseweg 72, 2333 AL, The, Leiden, Netherlands
    Gene 273:141-61. 2001
  7. ncbi A clinical and immunologic phase 2 trial of Wilms tumor gene product 1 (WT1) peptide vaccination in patients with AML and MDS
    Ulrich Keilholz
    Department of Hematology and Oncology, Charite Campus Benjamin Franklin, Hindenburgdamm 30, Berlin, Germany
    Blood 113:6541-8. 2009
  8. pmc Wt1 controls retinoic acid signalling in embryonic epicardium through transcriptional activation of Raldh2
    Juan Antonio Guadix
    Department of Animal Biology, University of Malaga, E29071 Malaga, Spain
    Development 138:1093-7. 2011
  9. pmc Septum transversum-derived mesothelium gives rise to hepatic stellate cells and perivascular mesenchymal cells in developing mouse liver
    Kinji Asahina
    Southern California Research Center for ALPD and Cirrhosis and Department of Pathology, Keck School of Medicine of the University of Southern California, Los Angeles, CA
    Hepatology 53:983-95. 2011
  10. pmc BASP1 is a transcriptional cosuppressor for the Wilms' tumor suppressor protein WT1
    Brian Carpenter
    School of Biological Sciences, University of Manchester, G 186 Stopford Building, Oxford Road, Manchester M13 9PT, UK
    Mol Cell Biol 24:537-49. 2004

Research Grants

  1. Targeting DNA Secondary Structures for Bcl-2 Gene Regulation
    Danzhou Yang; Fiscal Year: 2013
  2. RNA Targets of the Wilm's Tumor Protein in the Kidney
    Russ Carstens; Fiscal Year: 2005
  3. Role of Vascular Cells in kidney pattern formation
    Jordan A Kreidberg; Fiscal Year: 2010
  4. Transgenic Organ Cultures
    Jordan Kreidberg; Fiscal Year: 2004
  5. Genetic control of podocyte function
    Jordan Kreidberg; Fiscal Year: 2007
  6. Integrins in epithelial morphogenesis
    Jordan Kreidberg; Fiscal Year: 2009
  7. MOLECULAR CLASSIFICATION OF PROSTATE CANCER
    William Gerald; Fiscal Year: 2004
  8. Jade-1 in cystic renal disease
    Herbert Cohen; Fiscal Year: 2008
  9. Behavioral effects of cardiac arrest in mice
    ANNE DEVRIES; Fiscal Year: 2008
  10. GnRH signaling in LbetaT2 gonadotrope cells
    Nicholas Webster; Fiscal Year: 2009

Detail Information

Publications245 found, 100 shown here

  1. pmc Wt1 is required for cardiovascular progenitor cell formation through transcriptional control of Snail and E-cadherin
    Ofelia M Martinez-Estrada
    MRC Human Genetics Unit and Institute for Genetics and Molecular Medicine, Edinburgh, UK
    Nat Genet 42:89-93. 2010
    ..These new insights into the molecular mechanisms regulating cardiovascular progenitor cells and EMT will shed light on the pathogenesis of heart diseases and may help the development of cell-based therapies...
  2. pmc Epicardial progenitors contribute to the cardiomyocyte lineage in the developing heart
    Bin Zhou
    Harvard Stem Cell Institute and Department of Cardiology, Children s Hospital Boston, 300 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nature 454:109-13. 2008
    ..These results identify Wt1(+) epicardial cells as previously unrecognized cardiomyocyte progenitors, and lay the foundation for future efforts to harness the cardiogenic potential of these progenitors for cardiac regeneration and repair...
  3. ncbi The serosal mesothelium is a major source of smooth muscle cells of the gut vasculature
    Bettina Wilm
    Stahlman Cardiovascular Laboratories, Department of Medicine and Program for Developmental Biology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Development 132:5317-28. 2005
    ..Our data reveal a conserved mechanism in blood vessel formation to coelomic organs, and have major implications for our understanding of vertebrate organogenesis and vascular deficiencies of the gut...
  4. pmc Vaccination with synthetic analog peptides derived from WT1 oncoprotein induces T-cell responses in patients with complete remission from acute myeloid leukemia
    Peter G Maslak
    Leukemia Service, Department of Medicine, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA
    Blood 116:171-9. 2010
    ..Further studies are needed to establish the role of vaccination as viable postremission therapy for acute myeloid leukemia...
  5. pmc The Wilms tumor gene, Wt1, is required for Sox9 expression and maintenance of tubular architecture in the developing testis
    Fei Gao
    Department of Molecular Genetics Cancer Genetics, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 103:11987-92. 2006
    ..Our data, along with previous work demonstrating the role of Wt1 at early stages of gonadal development, thus indicate that Wt1 is essential at multiple steps in testicular development...
  6. ncbi WT1 proteins: functions in growth and differentiation
    V Scharnhorst
    Department of Molecular and Cellular Biology and Center for Biomedical Genetics, Leiden University Medical Center, Wassenaarseweg 72, 2333 AL, The, Leiden, Netherlands
    Gene 273:141-61. 2001
    ..Dependent on the tumor type, WT1 proteins might either function as tumor suppressor proteins or as survival factors...
  7. ncbi A clinical and immunologic phase 2 trial of Wilms tumor gene product 1 (WT1) peptide vaccination in patients with AML and MDS
    Ulrich Keilholz
    Department of Hematology and Oncology, Charite Campus Benjamin Franklin, Hindenburgdamm 30, Berlin, Germany
    Blood 113:6541-8. 2009
    ..18% at baseline and 0.41% in week 18. This WT1 vaccination study provides immunologic, molecular, and preliminary evidence of potential clinical efficacy in AML patients, warranting further investigations...
  8. pmc Wt1 controls retinoic acid signalling in embryonic epicardium through transcriptional activation of Raldh2
    Juan Antonio Guadix
    Department of Animal Biology, University of Malaga, E29071 Malaga, Spain
    Development 138:1093-7. 2011
    ....
  9. pmc Septum transversum-derived mesothelium gives rise to hepatic stellate cells and perivascular mesenchymal cells in developing mouse liver
    Kinji Asahina
    Southern California Research Center for ALPD and Cirrhosis and Department of Pathology, Keck School of Medicine of the University of Southern California, Los Angeles, CA
    Hepatology 53:983-95. 2011
    ..On the other hand, the Wt1(+) STM and MC/SubMCs do not contribute to sinusoidal endothelial cells, Kupffer cells, and hepatoblasts...
  10. pmc BASP1 is a transcriptional cosuppressor for the Wilms' tumor suppressor protein WT1
    Brian Carpenter
    School of Biological Sciences, University of Manchester, G 186 Stopford Building, Oxford Road, Manchester M13 9PT, UK
    Mol Cell Biol 24:537-49. 2004
    ..Taken together, our results show that BASP1 is a WT1-associated factor that can regulate WT1 transcriptional activity...
  11. ncbi Low Wilms' tumor gene expression in tumor tissues predicts poor prognosis in patients with non-small-cell lung cancer
    Seiji Hayashi
    Department of Internal Medicine, National Hospital Organization, Kinki chuo Chest Medical Center, Osaka, Japan
    Cancer Invest 30:165-71. 2012
    ..Cox analysis revealed that the gene level was a significant prognostic factor in OS and DFS. Low WT1 expression predicted poor prognosis in patients with NSCLC...
  12. pmc Sequence and structural requirements for high-affinity DNA binding by the WT1 gene product
    H Nakagama
    Center for Cancer Research, Massachusetts Institute of Technology, Cambridge 02139
    Mol Cell Biol 15:1489-98. 1995
    ..The role of the thymine base in contributing to binding affinity is discussed in the context of recent structural analysis...
  13. ncbi Wt1 and retinoic acid signaling are essential for stellate cell development and liver morphogenesis
    A IJpenberg
    MRC Human Genetics Unit, Western General Hospital, Edinburgh, UK
    Dev Biol 312:157-70. 2007
    ..Mechanistically, at least part of this effect is mediated via the retinoic acid signaling pathway...
  14. ncbi Repression of Pax-2 by WT1 during normal kidney development
    G Ryan
    Laboratory of Mammalian Genes and Development, National Institute of Child Health and Human Development, Bethesda, MD 02982
    Development 121:867-75. 1995
    ....
  15. ncbi Antilung cancer effect of WT1-specific cytotoxic T lymphocytes
    Masanori Makita
    First Department of Internal Medicine, Ehime University School of Medicine, Ehime 791 0295, Japan
    Clin Cancer Res 8:2626-31. 2002
    ..These findings strongly suggest that WT1 is a universal tumor-associated antigen and that WT1-targeting immunotherapy offers a potentially effective treatment option for lung cancer as well as leukemia...
  16. ncbi A cell-autonomous role for WT1 in regulating Sry in vivo
    Stephen T Bradford
    Division of Molecular Genetics and Development, Institute for Molecular Biosciences, The University of Queensland, Brisbane, Queensland, Australia
    Hum Mol Genet 18:3429-38. 2009
    ..Thus, sex reversal in Wt1(+KTS)-null mice and Frasier syndrome patients results from a failure of Sertoli cells both to fully differentiate and to reach sufficient numbers to direct testis development...
  17. ncbi The Wilms tumor suppressor Wt1 promotes cell adhesion through transcriptional activation of the alpha4integrin gene
    Karin M Kirschner
    Institut für Vegetative Physiologie, Charite Universitatsmedizin Berlin, Tucholskystrasse 2, 10117 Berlin, Germany
    J Biol Chem 281:31930-9. 2006
    ..This transcriptional activation of the alpha4integrin gene by Wt1(-KTS) might contribute to normal formation of the epicardium and other tissues in the developing embryo...
  18. pmc The Wilms tumor suppressor WT1 regulates early gonad development by activation of Sf1
    Dagmar Wilhelm
    Institut für Toxikologie und Genetik, Forschungszentrum Karlsruhe, 76021 Karlsruhe, Germany
    Genes Dev 16:1839-51. 2002
    ..Our data suggest a pathway in which the products of the Wt1 and Lhx9 genes activate expression of Sf1 and thus mediate early gonadogenesis...
  19. ncbi Telomerase regulation at the crossroads of cell fate
    A Cukusić
    Laboratory of Experimental Cancerology, Department of Molecular Biology, Ruder Boskovic Institute, Zagreb, Croatia
    Cytogenet Genome Res 122:263-72. 2008
    ..In this review we focus on the positive and negative regulators of hTERT transcription and their role in normal cell growth and immortalization...
  20. ncbi Overexpression of the Wilms' tumor gene WT1 in de novo lung cancers
    Yusuke Oji
    Department of Clinical Laboratory Science, Osaka University Medical School, Suita City, Osaka, Japan
    Int J Cancer 100:297-303. 2002
    ....
  21. ncbi Identification of novel Wilms' tumor suppressor gene target genes implicated in kidney development
    Ho Shik Kim
    Genetics of Development and Disease Branch, Microarray Core Facility, NIDDK, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 282:16278-87. 2007
    ..Our genome-wide screen implicates WT1 in the transcriptional regulation of the EGF-family of growth factors as well as the CX3CL1 chemokine during nephrogenesis...
  22. ncbi Wilms' tumor 1 and Dax-1 modulate the orphan nuclear receptor SF-1 in sex-specific gene expression
    M W Nachtigal
    Department of Physiology, University of California at San Francisco, 94143 0444, USA
    Cell 93:445-54. 1998
    ..We propose that WT1 and Dax-1 functionally oppose each other in testis development by modulating SF-1-mediated transactivation...
  23. ncbi Overexpression of the Wilms' tumor gene WT1 in pancreatic ductal adenocarcinoma
    Yusuke Oji
    Department of Functional Diagnostic Science, Osaka University Graduate School of Medicine, Suita, Osaka 565 0871, Japan
    Cancer Sci 95:583-7. 2004
    ....
  24. pmc Characterization of the genomic breakpoint and chimeric transcripts in the EWS-WT1 gene fusion of desmoplastic small round cell tumor
    W L Gerald
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10021
    Proc Natl Acad Sci U S A 92:1028-32. 1995
    ..The chimeric products are predicted to modulate transcription at WT1 target sites and contribute to development of this unique tumor...
  25. ncbi Early development of the zebrafish pronephros and analysis of mutations affecting pronephric function
    I A Drummond
    Renal Unit, Massachusetts General Hospital, Charlestown MA 02129, USA
    Development 125:4655-67. 1998
    ..These studies reveal the similarity of normal pronephric development to kidney organogenesis in all vertebrates and allow for a genetic dissection of genes needed to establish the earliest renal function...
  26. ncbi WT1 in acute leukemia, chronic myelogenous leukemia and myelodysplastic syndrome: therapeutic potential of WT1 targeted therapies
    C Rosenfeld
    Leukemia 17:1301-12. 2003
    ..In this paper, we review studies validating the immunogenicity of WT1 and propose that leukemia and MDS may be a good clinical model to test the efficacy of a WT1 vaccine...
  27. ncbi Improved expression and reactivity of transduced tumor-specific TCRs in human lymphocytes by specific silencing of endogenous TCR
    Sachiko Okamoto
    Center for Cell and Gene Therapy, Takara Bio, Inc, Shiga, Japan
    Cancer Res 69:9003-11. 2009
    ..In consequence, the vector-transduced lymphocytes showed enhanced cytotoxic activity against antigen-expressing tumor cells. Therefore, our novel TCR gene therapy may open a new gate for effective immunotherapy in cancer patients...
  28. ncbi Wilms' tumor suppressor gene (WT1) is expressed in primary breast tumors despite tumor-specific promoter methylation
    D M Loeb
    Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
    Cancer Res 61:921-5. 2001
    ..Our results demonstrate expression of WT1 in mammary neoplasia, and that WT1 may not have a tumor suppressor role in breast cancer...
  29. pmc WT1 interacts with the splicing factor U2AF65 in an isoform-dependent manner and can be incorporated into spliceosomes
    R C Davies
    Medical Research Council MRC Human Genetics Unit, Western General Hospital, Edinburgh EH4 2XU, UK
    Genes Dev 12:3217-25. 1998
    ..These data illustrate the functional importance of WT1 isoforms and suggest that WT1 plays a role in pre-mRNA splicing...
  30. ncbi Wilms tumor suppressor, Wt1, is a transcriptional activator of the erythropoietin gene
    Christof Dame
    Department of Neonatology, Campus Virchow Klinikum, Charite Universitatsmedizin Berlin, Augustenburger Platz 1, D 13353 Berlin, Germany
    Blood 107:4282-90. 2006
    ..Both proteins were also detected in Sertoli cells of the adult murine testis. In conclusion, we identified Wt1(-KTS) as a novel transcriptional activator for the tissue-specific expression of the EPO gene...
  31. ncbi WT1 is a key regulator of podocyte function: reduced expression levels cause crescentic glomerulonephritis and mesangial sclerosis
    Jian Kan Guo
    Max Delbruck Center for Molecular Medicine, Berlin Buch, Germany
    Hum Mol Genet 11:651-9. 2002
    ....
  32. pmc The Wilms' tumor gene Wt1 is required for normal development of the retina
    Kay Dietrich Wagner
    Johannes Müller Institut für Physiologie, Medizinische Fakultät Charité, Humboldt Universitat, Berlin, Germany
    EMBO J 21:1398-405. 2002
    ..Taken together, our findings demonstrate a continuous requirement for Wt1 in normal retina formation with a critical role in Pou4f2-dependent ganglion cell differentiation...
  33. ncbi Gene expression profiling of favorable histology Wilms tumors and its correlation with clinical features
    Masayuki Takahashi
    Laboratory of Cancer Genetics, Van Andel Research Institute, Grand Rapids, Michigan 49503, USA
    Cancer Res 62:6598-605. 2002
    ..In summary, our findings suggest that the integration of gene expression data and clinical parameters could aid in detecting aggressive tumors among favorable histology WT and lead to the discovery of new drugs for WT...
  34. pmc Regulation of vascular endothelial growth factor, VEGF, gene promoter by the tumor suppressor, WT1
    Julie Hanson
    Department of Biological Sciences, Kent State University, Kent, OH 44242, USA
    Front Biosci 12:2279-90. 2007
    ..These findings may shed light on the role of WT1 in angiogenesis and prostate cancer progression...
  35. ncbi Cyclin E is a target of WT1 transcriptional repression
    David M Loeb
    Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore, Maryland 21231, USA
    J Biol Chem 277:19627-32. 2002
    ..In intact cells, induction of WT1 expression down-regulates cyclin E protein levels. These results provide the first demonstration that WT1 can directly modulate the expression of a gene involved in cell cycle progression...
  36. ncbi A phase I/II trial of a WT1 (Wilms' tumor gene) peptide vaccine in patients with solid malignancy: safety assessment based on the phase I data
    Satoshi Morita
    Department of Epidemiology and Health Care Research, Kyoto University Graduate School of Medicine, Yoshidakonoe cho, Sakyo ku, Kyoto 606 8501, Japan
    Jpn J Clin Oncol 36:231-6. 2006
    ..We conducted a phase I study to investigate the safety of a weekly WT1 tumor vaccine therapy in patients with solid tumors that had been refractory to all other anti-cancer therapies...
  37. ncbi The role of Wt1 in regulating mesenchyme in cancer, development, and tissue homeostasis
    You Ying Chau
    MRC Human Genetics Unit and Institute of Genetics and Molecular Medicine at the University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh, EH4 2XU, UK
    Trends Genet 28:515-24. 2012
    ..We believe that future studies aimed at elucidating the mechanisms underlying the functions of Wt1 in adult cells will reveal key cell types, pathways, and molecules regulating adult tissue homeostasis and repair...
  38. pmc Acute multiple organ failure in adult mice deleted for the developmental regulator Wt1
    You Ying Chau
    Medical Research Council Human Genetics Unit and the Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, United Kingdom
    PLoS Genet 7:e1002404. 2011
    ....
  39. ncbi A non-AUG translational initiation event generates novel WT1 isoforms
    W Bruening
    Department of Biochemistry, McGill University, 3655 Drummond St, Montreal, Quebec H3G 1Y6, Canada
    J Biol Chem 271:8646-54. 1996
    ..Our results indicate that regulation of WT1 gene expression is more complex than previously suspected and have important implications for normal and abnormal urogenital system development...
  40. ncbi Par-4 transcriptionally regulates Bcl-2 through a WT1-binding site on the bcl-2 promoter
    Sangeeta K Cheema
    Department of Bioimmunotherapy, Section of Immunobiology and Drug Carrier, University of Texas M D Anderson Cancer Center, Houston 77030, USA
    J Biol Chem 278:19995-20005. 2003
    ..Finally, we detected Par-4 and WT1 proteins binding to a previously identified WT1-binding site on the bcl-2 promoter both in vitro and in vivo leading to ..
  41. ncbi Subnuclear localization of WT1 in splicing or transcription factor domains is regulated by alternative splicing
    S H Larsson
    Medical Research Council Human Genetics Unit, Western General Hospital, Edinburgh, Scotland
    Cell 81:391-401. 1995
    ..We propose that WT1 plays roles in posttranscriptional processing of RNA as well as in transcription...
  42. ncbi Wt1 and epicardial fate mapping
    Carsten Rudat
    Institut fur Molekularbiologie, Medizinische Hochschule Hannover, Hannover, Germany
    Circ Res 111:165-9. 2012
    ..Genetic lineage tracing systems based on Wt1 regulatory sequences provided evidence that epicardium-derived cells also adopt a myocardial fate in the mouse...
  43. ncbi Curcumin inhibits WT1 gene expression in human leukemic K562 cells
    Songyot Anuchapreeda
    Division of Clinical Microscopy, Department of Medical Technology, Faculty of Associated Medical Sciences Chiang Mai University, Chiang Mai 50200, Thailand
    Acta Pharmacol Sin 27:360-6. 2006
    ..The purpose of this study was to investigate the modulating effects of curcumin on WT1 gene expression in the human leukemic cell line K562...
  44. pmc miR-15a and miR-16-1 inhibit the proliferation of leukemic cells by down-regulating WT1 protein level
    Shen meng Gao
    Laboratory of Internal Medicine, The First Affiliated Hospital of Wenzhou Medical College, China
    J Exp Clin Cancer Res 30:110. 2011
    ..However the mechanism of inhibiting the proliferation of leukemic cells is poorly understood...
  45. pmc Urinary exosomal transcription factors, a new class of biomarkers for renal disease
    Hua Zhou
    Renal Diagnostics and Therapeutics Unit, National Institutes of Health, Bethesda, Maryland, USA
    Kidney Int 74:613-21. 2008
    ..Measurement of urinary exosomal transcription factors may offer insight into cellular regulatory pathways...
  46. pmc Induction of complete and molecular remissions in acute myeloid leukemia by Wilms' tumor 1 antigen-targeted dendritic cell vaccination
    Viggo F Van Tendeloo
    University of Antwerp, Faculty of Medicine, Vaccine and Infectious Disease Institute Vaxinfectio and Center for Cell Therapy and Regenerative Medicine, Antwerp University Hospital, Antwerp B 2650, Belgium
    Proc Natl Acad Sci U S A 107:13824-9. 2010
    ..These data support the further development of vaccination with WT1 mRNA-loaded dendritic cells as a postremission treatment to prevent full relapse in AML patients...
  47. ncbi Wilms' tumour gene 1 (WT1) as a target in curcumin treatment of pancreatic cancer cells
    Wolfgang Glienke
    Department of Medicine II Hämatologie Onkologie, University Hospital, Johann Wolfgang Goethe University, Frankfurt am Main, Germany
    Eur J Cancer 45:874-80. 2009
    ..In conclusion, WT1 is involved in cellular proliferation of PANC-1 cells. Targeting WT1 gene expression with siRNA may enhance the efficacy of curcumin to inhibit cell proliferation...
  48. ncbi Urinary exosomal WT1 in childhood nephrotic syndrome
    Hyunkyung Lee
    Department of Pediatrics, Seoul National University Children s Hospital, 101 Daehak Ro, Jongno gu, Seoul, 110 744, Korea
    Pediatr Nephrol 27:317-20. 2012
    ..The remaining 12 (30%) were steroid-resistant, including 8 with FSGS and 4 with MCNS. Urinary exosomes were isolated by a differential centrifugation method, and WT1 was measured by Western blot analysis...
  49. pmc WT1 regulates epicardial epithelial to mesenchymal transition through β-catenin and retinoic acid signaling pathways
    Alexander von Gise
    Department of Cardiology, Children s Hospital Boston, 300 Longwood Ave, Boston, MA, USA
    Dev Biol 356:421-31. 2011
    ..Collectively, our study shows that Wt1 regulates epicardial EMT and heart development through canonical Wnt, non-canonical Wnt, and retinoic acid signaling pathways...
  50. ncbi The many facets of the Wilms' tumour gene, WT1
    Peter Hohenstein
    MRC Human Genetics Unit, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK
    Hum Mol Genet 15:R196-201. 2006
    ....
  51. ncbi A splice variant of the Wilms' tumour suppressor Wt1 is required for normal development of the olfactory system
    Nicole Wagner
    Inserm U636, Centre de Biochimie, Faculte des Sciences, Nice, France
    Development 132:1327-36. 2005
    ..Furthermore, neuron formation depends on distinct functions of alternatively spliced Wt1 products in the embryonic retina and the olfactory epithelium...
  52. ncbi The Wilms' tumor suppressor Wt1 is expressed in the coronary vasculature after myocardial infarction
    Kay Dietrich Wagner
    Johannes Müller Institut für Physiologie and, Klinik fur Innere Medizin I, Humboldt Universitat, Charite, 10117 Berlin, Germany
    FASEB J 16:1117-9. 2002
    ..These findings demonstrate that Wt1 is expressed in the vasculature of the heart in response to local ischemia and hypoxia. They suggest that Wt1 has a role in the growth of coronary vessels after myocardial infarction...
  53. ncbi Overexpression of the Wilms' tumor gene W T1 in primary astrocytic tumors
    Yusuke Oji
    Department of Bioinformatics, Osaka University Graduate School of Medicine, 1 7 Yamada oka, Suita, Osaka 565 0871, Japan
    Cancer Sci 95:822-7. 2004
    ..These results may indicate that the W T1 gene plays an important role in tumorigenesis of primary astrocytic tumors...
  54. ncbi Clinical, pathologic, and molecular spectrum of tumors associated with t(11;22)(p13;q12): desmoplastic small round-cell tumor and its variants
    W L Gerald
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Clin Oncol 16:3028-36. 1998
    ..We reviewed 109 cases of DSRCT to further characterize this entity better...
  55. ncbi WT1 regulates the expression of the major glomerular podocyte membrane protein Podocalyxin
    R E Palmer
    Massachusetts General Hospital Cancer Center and Harvard Medical School, Charlestown, MA 02129, USA
    Curr Biol 11:1805-9. 2001
    ..These observations support a role for WT1 in the specific activation of a glomerular differentiation program in renal precursors and provide a molecular basis for the glomerulonephropathy that is characteristic of Denys-Drash Syndrome...
  56. pmc Repeated PR1 and WT1 peptide vaccination in Montanide-adjuvant fails to induce sustained high-avidity, epitope-specific CD8+ T cells in myeloid malignancies
    Katayoun Rezvani
    Department of Hematology, Imperial College, Hammersmith Campus, 4th Floor, Commonwealth Building, DuCane Rd, London W12 0NN, UK
    Haematologica 96:432-40. 2011
    ..We previously showed that vaccination with one dose of PR1 and WT1 peptides induces transient anti-leukemia immunity. We hypothesized that maintenance of a sustained anti-leukemia response may require frequent boost injections...
  57. ncbi Transcriptional regulation by WT1 in development
    Stefan G E Roberts
    Faculty of Life Sciences, The Michael Smith Building, University of Manchester, Oxford Road, Manchester, M13 9PT, UK
    Curr Opin Genet Dev 15:542-7. 2005
    ..In addition, ongoing studies of transgenic animals and analyses in kidney explant systems have revealed further roles for WT1 in development...
  58. pmc The Wilms' tumor 1 (WT1) gene (+KTS isoform) functions with a CTE to enhance translation from an unspliced RNA with a retained intron
    Yeou Cherng Bor
    Myles H Thaler Center for AIDS and Human Retrovirus Research and Department of Microbiology, University of Virginia, Charlottesville, Virginia 22908, USA
    Genes Dev 20:1597-608. 2006
    ..These studies provide further support for links between different steps in RNA metabolism and for the existence of post-transcriptional operons...
  59. ncbi Suppression of prostate tumor cell growth in vivo by WT1, the Wilms' tumor suppressor gene
    Gail Fraizer
    Department of Biological Sciences, Kent State University, Kent, OH 44242, USA
    Int J Oncol 24:461-71. 2004
    ..This suggests that the mechanism of WT1-mediated growth suppression does not rely upon DNA binding at known WT1 recognition sites...
  60. pmc WT1 suppresses synthesis of the epidermal growth factor receptor and induces apoptosis
    C Englert
    Laboratory of Molecular Genetics, Massachusetts General Hospital Cancer Center, Charlestown 02129, USA
    EMBO J 14:4662-75. 1995
    ..Repression of EGFR and induction of apoptosis by mechanism that may contribute to its critical role in normal kidney development and to the immortalization of tumor cells with inactivated WT1 alleles...
  61. ncbi T-cell responses directed against multiple HLA-A*0201-restricted epitopes derived from Wilms' tumor 1 protein in patients with leukemia and healthy donors: identification, quantification, and characterization
    Katayoun Rezvani
    Stem Cell Allotransplantation Section, Hematology Branch, National Heart Lung Blood Institute and Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland 20892, USA
    Clin Cancer Res 11:8799-807. 2005
    ..Four HLA-A*0201-restricted WT1-derived epitopes have been identified: WT37, WT126, WT187, and WT235. We determined the natural immunogenecity of these antigens in patients with hematologic malignancies and healthy donor...
  62. ncbi YAC complementation shows a requirement for Wt1 in the development of epicardium, adrenal gland and throughout nephrogenesis
    A W Moore
    MRC Human Genetics Unit, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK
    Development 126:1845-57. 1999
    ..These data demonstrate a variety of new functions for WT1 and suggest a general requirement for this protein in the formation of organs derived from the intermediate mesoderm...
  63. ncbi The role of WT1 in oncogenesis: tumor suppressor or oncogene?
    David M Loeb
    Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland, USA
    Int J Hematol 76:117-26. 2002
    ..The prognostic implications of altered WT1 expression and the potential for immunotherapy aimed at WT1 are also discussed...
  64. ncbi Overexpression of the Wilms' tumor gene WT1 in primary thyroid cancer
    Yusuke Oji
    Department of Functional Diagnostic Science, Osaka University Graduate School of Medicine, Suita, Osaka 565 0871, Japan
    Cancer Sci 94:606-11. 2003
    ..These findings indicate an important role of the wild-type WT1 gene in the tumorigenesis of primary thyroid cancer...
  65. ncbi Sry and Sox9: mammalian testis-determining genes
    P Koopman
    Centre for Molecular and Cellular Biology, University of Queensland, Brisbane, Australia
    Cell Mol Life Sci 55:839-56. 1999
    ....
  66. pmc In vitro epithelial-to-mesenchymal transformation in human adult epicardial cells is regulated by TGFβ-signaling and WT1
    Noortje A M Bax
    Department of Anatomy and Embryology, Leiden University Medical Center, Leiden, The Netherlands
    Basic Res Cardiol 106:829-47. 2011
    ..These data provide new insights into the process of EMT in human adult epicardial cells, which might provide opportunities to develop new strategies for endogenous cell-based cardiac repair...
  67. ncbi Intermediate filament protein nestin is expressed in developing kidney and heart and might be regulated by the Wilms' tumor suppressor Wt1
    Nicole Wagner
    Institut National de la Santé et de la Recherche Médicale U636, Centre de Biochimie, Faculte des Sciences, Universite de Nice, 06108 Nice, France
    Am J Physiol Regul Integr Comp Physiol 291:R779-87. 2006
    ..Our results show that nestin is expressed at different stages of kidney and cardiac development and suggest that its expression in these organs might be regulated by the Wilms' tumor suppressor Wt1...
  68. ncbi YAC transgenic analysis reveals Wilms' tumour 1 gene activity in the proliferating coelomic epithelium, developing diaphragm and limb
    A W Moore
    MRC Human Genetics Unit, Western General Hospital, Edinburg, UK
    Mech Dev 79:169-84. 1998
    ..Finally, Wt1 is expressed in mesenchymal cells derived from the coelomic epithelium. Based upon these and further data we discuss a Wt1 role in epithelial<-->mesenchymal transitions...
  69. ncbi Peptide epitopes from the Wilms' tumor 1 oncoprotein stimulate CD4+ and CD8+ T cells that recognize and kill human malignant mesothelioma tumor cells
    Rena J May
    Molecular Pharmacology and Chemistry Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Clin Cancer Res 13:4547-55. 2007
    ..The induction and maintenance of a robust memory CD8(+) cytotoxic T-cell response requires CD4(+) T-cell help...
  70. ncbi Antiapoptotic function of 17AA(+)WT1 (Wilms' tumor gene) isoforms on the intrinsic apoptosis pathway
    K Ito
    Department of Functional Diagnostic Science, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Oncogene 25:4217-29. 2006
    ..Taken together, these results indicated that 17AA(+)WT1 isoforms played antiapoptotic roles at some points upstream of the mitochondria in the intrinsic apoptosis pathway...
  71. ncbi New insights into the function of the Wilms tumor suppressor gene WT1 in podocytes
    Avril A Morrison
    Bristol Genomics Research Institute, Centre for Research in Biomedicine, Faculty of Health and Life Sciences, University of the West of England, Bristol, UK
    Am J Physiol Renal Physiol 295:F12-7. 2008
    ..Recent advances including the development of transgenic mouse models and conditionally immortalized podocyte cell lines are beginning to shed light on WT1's crucial role in podocyte function...
  72. ncbi WT1 gene expression: an excellent tool for monitoring minimal residual disease in 70% of acute myeloid leukaemia patients - results from a single-centre study
    Mette Østergaard
    Department of Haematology, Aarhus University Hospital, Aarhus, Denmark
    Br J Haematol 125:590-600. 2004
    ..We conclude that WT1 expression by RQ-PCR may be employed as a tool to detect MRD in the majority of fusion transcript-negative AML patients...
  73. ncbi WT1 peptide-based immunotherapy for patients with lung cancer: report of two cases
    Akihiro Tsuboi
    Department of Cancer Immunotherapy, Osaka University Graduate School of Medicine, Japan
    Microbiol Immunol 48:175-84. 2004
    ..These results provided us with the first clinical evidence demonstrating that WT1 peptide-based immunotherapy should be a promising treatment for patients with lung cancer...
  74. ncbi Regulation of nov by WT1: a potential role for nov in nephrogenesis
    C Martinerie
    Laboratoire d Oncologie Virale et Moléculaire, Institut Curie, Orsay, France
    Oncogene 12:1479-92. 1996
    ..experiments the transcription activity of novH promoter constructs was repressed by two isoforms of WT1 proteins (WT1 and WT1+KTS)...
  75. ncbi Wt1-expressing progenitors contribute to multiple tissues in the developing lung
    Elena Cano
    Dept of Animal Biology, Faculty of Sciences, Univ of Malaga, 29071 Malaga, Spain
    Am J Physiol Lung Cell Mol Physiol 305:L322-32. 2013
    ..Our results suggest a novel role for the embryonic mesothelium-derived cells in lung morphogenesis and involve the Wilms' tumor suppressor gene in the development of this organ...
  76. pmc Dynamic interaction between WT1 and BASP1 in transcriptional regulation during differentiation
    Laura M Green
    Faculty of Life Sciences, The Michael Smith Building University of Manchester Oxford Road, Manchester M13 9PT, UK
    Nucleic Acids Res 37:431-40. 2009
    ..We provide evidence that the regulation of BASP1 promoter occupancy involves the sumoylation of BASP1. Our results reveal a dynamic cooperation between WT1 and BASP1 in the regulation of gene expression during differentiation...
  77. ncbi Role of Wilms tumor 1 (WT1) in the transcriptional regulation of the Mullerian-inhibiting substance promoter
    Anwar Hossain
    Department of Biochemistry and Molecular Biology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030 4009, USA
    Biol Reprod 69:1808-14. 2003
    ..The WT1 is an essential factor for activation of the Mis promoter; therefore, the persistence of the mullerian duct in patients with Denys-Drash syndrome may result from deregulation of the MIS gene...
  78. ncbi Wilms tumor gene peptide-based immunotherapy for patients with overt leukemia from myelodysplastic syndrome (MDS) or MDS with myelofibrosis
    Yoshihiro Oka
    Department of Molecular Medicine, Osaka University Medical School, Suita City, Osaka, Japan
    Int J Hematol 78:56-61. 2003
    ..These results have provided us with the first clinical evidence suggesting that WT1 peptide-based immunotherapy is an attractive treatment for patients with leukemias or MDS...
  79. ncbi Wilms' tumor (WT1) gene mutations occur mainly in acute myeloid leukemia and may confer drug resistance
    L King-Underwood
    Section of Paediatric Oncology, Institute of Cancer Research, Belmont, Sutton, Surrey, UK
    Blood 91:2961-8. 1998
    ..The relationship of WT1 mutation to chemoresistance merits further investigation...
  80. ncbi Overexpression of the Wilms' tumor gene WT1 in human bone and soft-tissue sarcomas
    Takafumi Ueda
    Department of Orthopaedic Surgery, Osaka University Graduate School of Medicine, Suita, Osaka
    Cancer Sci 94:271-6. 2003
    ....
  81. ncbi WT1 as a complementary marker of malignant melanoma: an immunohistochemical study of whole sections
    M Wilsher
    Douglass Hanly Moir Pathology, Department of Histopathology, Sydney, NSW, Australia
    Histopathology 51:605-10. 2007
    ..To test the usefulness of WT1 as a diagnostic aid in melanoma diagnosis and prognostication...
  82. ncbi Sensitive immunohistochemical detection of WT1 protein in tumors with anti-WT1 antibody against WT1 235 peptide
    Ryo Ichinohasama
    Division of Hematopathology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Cancer Sci 101:1089-92. 2010
    ....
  83. pmc A zinc finger truncation of murine WT1 results in the characteristic urogenital abnormalities of Denys-Drash syndrome
    C E Patek
    Sir Alastair Currie CRC Laboratories, Molecular Medicine Centre, The University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, United Kingdom
    Proc Natl Acad Sci U S A 96:2931-6. 1999
    ..However, the mutant WT1(tmT396) protein accounted for only 5% of WT1 in both heterozygous embryonic stem cells and the WT. This has implications regarding the mechanism by which the mutant allele exerts its effect...
  84. ncbi Gonadal differentiation, sex determination and normal Sry expression in mice require direct interaction between transcription partners GATA4 and FOG2
    Sergei G Tevosian
    Division of Hematology and Oncology, Children s Hospital, Harvard Medical School, Boston, MA, USA
    Development 129:4627-34. 2002
    ..These results indicate that GATA4 and FOG2 and their physical interaction are required for normal gonadal development...
  85. pmc Genomic characterization of Wilms' tumor suppressor 1 targets in nephron progenitor cells during kidney development
    Sunny Hartwig
    Department of Medicine, Children s Hospital Boston Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA
    Development 137:1189-203. 2010
    ....
  86. ncbi Immunohistochemical detection of WT1 protein in endometrial cancer
    Satoshi Ohno
    Department of Obstetrics and Gynecology, Kanazawa University, Graduate School of Medical Science, 13 1 Takaramachi, Kanazawa, Ishikawa 920 8640 Japan
    Anticancer Res 29:1691-5. 2009
    ..The Wilms' tumor gene WT1 is overexpressed in various kinds of solid tumors. However, it remains unclear whether WT1 plays a pathophysiological role in endometrial cancer...
  87. ncbi Differential expression of WT1 gene product in non-Hodgkin lymphomas
    Elias Drakos
    Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Appl Immunohistochem Mol Morphol 13:132-7. 2005
    ..WT1 immunoreactivity was primarily cytoplasmic in all positive NHLs except T-cell lymphoblastic lymphoma. In conclusion, WT1 protein is frequently detected in the cytoplasm of a subset of high-grade NHLs...
  88. ncbi WT1: what has the last decade told us?
    M Little
    Centre for Molecular and Cellular Biology, University of Queensland, Brisbane, Australia
    Bioessays 21:191-202. 1999
    ..b>WT1 proteins act as nucleic acid-binding zinc finger-containing transcription factors involved in both transactivation and ..
  89. pmc Analysis of gene expression in prostate cancer epithelial and interstitial stromal cells using laser capture microdissection
    Jennifer L Gregg
    School of Biomedical Sciences, Kent State University, Kent, OH, USA
    BMC Cancer 10:165. 2010
    ..This report presents the first study of prostate tumor tissue that examines patterns of differential expression between specific cell types using laser capture microdissection (LCM)...
  90. ncbi Effect of pure curcumin, demethoxycurcumin, and bisdemethoxycurcumin on WT1 gene expression in leukemic cell lines
    Songyot Anuchapreeda
    Division of Clinical Microscopy, Department of Medical Technology, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, Thailand
    Cancer Chemother Pharmacol 62:585-94. 2008
    ..Curcuminoids consist of pure curcumin, demethoxycurcumin, and bisdemethoxycurcumin. In this study, the effect of each curcuminoids'components on WT1 gene expression in leukemic cell lines (K562, HL60, U937, and Molt4) was investigated...
  91. ncbi Wilms' tumor gene 1 (WT1) expression in childhood acute lymphoblastic leukemia: a wide range of WT1 expression levels, its impact on prognosis and minimal residual disease monitoring
    L Boublikova
    Department of Hematology, Durkan Leukemia Research Laboratories, Institute of Molecular Medicine, Trinity College and St James s Hospital, Dublin, Ireland
    Leukemia 20:254-63. 2006
    ..Interestingly, a proportion of childhood ALL patients express WT1 at levels below the normal physiological BM WT1 expression, and this reduced WT1 expression appears to be associated with a higher risk of relapse...
  92. pmc PAX8-mediated activation of the wt1 tumor suppressor gene
    M Dehbi
    Department of Biochemistry, McGill University, Montreal, Quebec, Canada
    EMBO J 15:4297-306. 1996
    ....
  93. ncbi Inhibitory mechanism of pure curcumin on Wilms' tumor 1 (WT1) gene expression through the PKCα signaling pathway in leukemic K562 cells
    Suwanna Semsri
    Division of Clinical Microscopy, Department of Medical Technology, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, Thailand
    FEBS Lett 585:2235-42. 2011
    ..Our study indicates that pure curcumin attenuates WT1 auto-regulatory function through inhibition of PKCα signaling in K562 cells...
  94. ncbi Activated omentum becomes rich in factors that promote healing and tissue regeneration
    Natalia O Litbarg
    Department of Medicine, Stroger Hospital of Cook County, Chicago, IL 60612, USA
    Cell Tissue Res 328:487-97. 2007
    ..Thus, we propose that an omentum activated by a foreign body (or by injury) greatly expands its milky-spot tissue and becomes rich in growth factors and progenitor cells that facilitate the healing and regeneration of injured tissue...
  95. pmc Developmental patterns and characteristics of epicardial cell markers Tbx18 and Wt1 in murine embryonic heart
    Bin Zeng
    Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, Hubei, PR China
    J Biomed Sci 18:67. 2011
    ..The present study therefore aimed to examine the the expression of Tbx18 and Wt1 in embryonic heart and to identify whether Tbx18 and Wt1 themselves expressed in the cardiomyocyte...
  96. pmc Cardiac malformations in Pdgfralpha mutant embryos are associated with increased expression of WT1 and Nkx2.5 in the second heart field
    Noortje A M Bax
    Department of Anatomy and Embryology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
    Dev Dyn 239:2307-17. 2010
    ..Our data provide novel insight for a possible role for Pdgfralpha in transduction pathways that lead to repression of Nkx2.5 and WT1 during development of posterior heart field-derived cardiac structures...
  97. ncbi In vitro methods for generating CD8+ T-cell clones for immunotherapy from the naïve repertoire
    William Y Ho
    Program in Immunology, Fred Hutchinson Cancer Research Center and the Department of Medicine, University of Washington, Seattle, WA 98109, USA
    J Immunol Methods 310:40-52. 2006
    ....
  98. pmc WT1 peptide vaccinations induce CD4 and CD8 T cell immune responses in patients with mesothelioma and non-small cell lung cancer
    Lee M Krug
    Department of Medicine, Memorial Sloan Kettering Cancer Center, Weill Medical College of Cornell University, 1275 York Ave, New York, NY, 10065, USA
    Cancer Immunol Immunother 59:1467-79. 2010
    ..We tested the safety and immunogenicity of a WT1 vaccine comprised of four class I and class II peptides in patients with thoracic neoplasms expressing WT1...
  99. pmc Leukemia-associated antigen-specific T-cell responses following combined PR1 and WT1 peptide vaccination in patients with myeloid malignancies
    Katayoun Rezvani
    Stem Cell Allotransplantation Section, Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1201, USA
    Blood 111:236-42. 2008
    ..01). This is the first demonstration that a combined PR1 and WT1 vaccine is immunogenic. These results support further studies of combination immunization strategies in leukemia patients...
  100. ncbi Functional characterization of WT1 binding sites within the human vitamin D receptor gene promoter
    T H Lee
    Department of Biochemistry, McGill Cancer Center, McGill University, Montreal, Quebec, Canada H3G 1Y6
    Physiol Genomics 7:187-200. 2001
    ..Our results indicate that the human VDR gene is a downstream target of WT1 and may be regulated differently than its murine counterpart...
  101. ncbi The Wilms' tumour suppressor WT1 is involved in endothelial cell proliferation and migration: expression in tumour vessels in vivo
    N Wagner
    INSERM U907, Nice, France
    Oncogene 27:3662-72. 2008
    ..These findings suggest that transcriptional activation of ETS-1 by the Wilms' tumour suppressor WT1 is a crucial step in tumour vascularization via regulation of endothelial cell proliferation and migration...

Research Grants24

  1. Targeting DNA Secondary Structures for Bcl-2 Gene Regulation
    Danzhou Yang; Fiscal Year: 2013
    ..Effective modulation of bcl-2 expression offers promise for the treatment of these diseases. The proposed research represents a novel new strategy for modulating bcl-2 gene expression by small molecule drugs. ..
  2. RNA Targets of the Wilm's Tumor Protein in the Kidney
    Russ Carstens; Fiscal Year: 2005
    ..Microarrays will be used to identity of specific RNAs that specifically co-IP with WTI(+KTS). ..
  3. Role of Vascular Cells in kidney pattern formation
    Jordan A Kreidberg; Fiscal Year: 2010
    ..The aims of this grant are designed to more fully determine the molecular nature of the angioblast signal, and how it may be involved in stimulating branching, and patterning the embryonic kidney. ..
  4. Transgenic Organ Cultures
    Jordan Kreidberg; Fiscal Year: 2004
    ..abstract_text> ..
  5. Genetic control of podocyte function
    Jordan Kreidberg; Fiscal Year: 2007
    ..abstract_text> ..
  6. Integrins in epithelial morphogenesis
    Jordan Kreidberg; Fiscal Year: 2009
    ..Specific Aim 2: To examine the role of integrin-dependent Writ signaling in epithelial morphogenesis. Specific Aim 3: To determine the requirement for a3b1 integrin:tetraspanin interaction in morphogenesis of the collecting system. ..
  7. MOLECULAR CLASSIFICATION OF PROSTATE CANCER
    William Gerald; Fiscal Year: 2004
    ..abstract_text> ..
  8. Jade-1 in cystic renal disease
    Herbert Cohen; Fiscal Year: 2008
    ..abstract_text> ..
  9. Behavioral effects of cardiac arrest in mice
    ANNE DEVRIES; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  10. GnRH signaling in LbetaT2 gonadotrope cells
    Nicholas Webster; Fiscal Year: 2009
    ..These genetic models will include cell-specific transgenic overexpression of selected co-repressors as well as gonadotrope-specific deletion of components of the Gs and Gq/11 pathways using cre-loxP technology. ..
  11. Pathology of the FSGS Kidney
    Agnes B Fogo; Fiscal Year: 2010
    ..These approaches could ultimately identify novel therapeutic targets in FSGS. ..
  12. Mechanisms of Glomerular Scarring
    John Sedor; Fiscal Year: 2006
    ..In vitro and in vivo experiments will test the validity of our model. ..
  13. Role of PAX2 in Mammary Development and Cancer
    GARY SILBERSTEIN; Fiscal Year: 2005
    ..Finally, the possibility that PAX2 is a mammary tumor promoter will be evaluated, providing insights into mechanisms of breast cancer progression. ..
  14. New Paradigms in Vascular Biology: Renal Implications
    John Sedor; Fiscal Year: 2005
    ..The program is divided into 3 sessions: 1) Angiogenesis, 2) Development, and 3) Atherosclerosis, Inflammation, and Repair, in addition to a key note speaker. Of the confirmed speakers, 4 are women and 6 are men ..
  15. SOCIOBIOLOGICAL FACTORS IN EXPERIMENTAL STROKE OUTCOME
    ANNE DEVRIES; Fiscal Year: 2004
    ..abstract_text> ..
  16. Combinatorial Approaches to Activators of the NGF Recep*
    Nicholas Webster; Fiscal Year: 2005
    ..The Specific Aim of this proposal is to screen the combinatorial asterriquinone library against the NGF receptor. ..
  17. Regulation of VEGF by WT1
    Gail Fraizer; Fiscal Year: 2005
    ....
  18. TELOMERASE FUNCTIONS IN DIFFERENTIATION & TRANSFORMATION
    LEIF ELLISEN; Fiscal Year: 2003
    ..This work should further our understanding of the how events at the telomere regulate normal and malignant cell growth. ..
  19. Role of Retroelements in Environmental Atherogenesis
    Kenneth S Ramos; Fiscal Year: 2010
    ..Studies are proposed in this application to study the role of virus-like sequences in the onset and progression of environmentally-induced atherosclerosis in experimental systems. ..
  20. Effects of social factors on cardiac arrest outcome
    ANNE DEVRIES; Fiscal Year: 2009
    ....
  21. 2004 Mechanisms of Toxicity Gordon Research Conference
    Kenneth Ramos; Fiscal Year: 2004
    ..Thus, the 2004 conference is poised to continue its growth as the single leading small conference in toxicology. ..
  22. Case FIND Participating Investigative Center
    John Sedor; Fiscal Year: 2006
    ..These studies will be done by the Case PIC in conjunction with the GADCC and the other PICs. Second, the Case PIC will continue recruitment and phenotyping of 104 eligible FIND participants for FIND Retinopathy. ..
  23. OSTEOPONTIN AND OXIDATIVE STRESS IN ATHEROGENESIS
    Kenneth Ramos; Fiscal Year: 2003
    ..These studies are important in view of the increasing scrutiny of the role of oxidative injury in the onset and progression of atherogenesis. ..
  24. MOLECULAR MECHANISMS OF CHEMICAL ATHEROGENESIS
    Kenneth Ramos; Fiscal Year: 2005
    ..These studies will enable us to define the role of ARE/EpRE binding proteins in oxidant-induced atherogenesis and identify critical transacting factors involved in the atherogenic response to environmental injury. ..