rna binding protein fus

Summary

Summary: A multifunctional heterogeneous-nuclear ribonucleoprotein that may play a role in homologous DNA pairing and recombination. The N-terminal portion of protein is a potent transcriptional activator, while the C terminus is required for RNA binding. The name FUS refers to the fact that genetic recombination events result in fusion oncogene proteins (ONCOGENE PROTEINS, FUSION) that contain the N-terminal region of this protein. These fusion proteins have been found in myxoid liposarcoma (LIPOSARCOMA, MYXOID) and acute myeloid leukemia.

Top Publications

  1. ncbi Gene expression profile identifies a rare epithelioid variant case of pleomorphic liposarcoma carrying FUS-CHOP transcript
    L De Cecco
    FIRC Institute for Molecular Oncology Foundation, IFOM, Milano, Italy
    Histopathology 46:334-41. 2005
  2. ncbi TLS facilitates transport of mRNA encoding an actin-stabilizing protein to dendritic spines
    Ritsuko Fujii
    Osaka Bioscience Institute, Suita, Osaka 565 0874, Japan
    J Cell Sci 118:5755-65. 2005
  3. pmc Abundant FUS-immunoreactive pathology in neuronal intermediate filament inclusion disease
    Manuela Neumann
    Institute of Neuropathology, University Hospital of Zurich, Zurich, Switzerland
    Acta Neuropathol 118:605-16. 2009
  4. ncbi FUS-immunoreactive inclusions are a common feature in sporadic and non-SOD1 familial amyotrophic lateral sclerosis
    Han Xiang Deng
    Division of Neuromuscular Medicine, Davee Department of Neurology and Clinical Neurosciences, Chicago, IL 60611, USA
    Ann Neurol 67:739-48. 2010
  5. ncbi The RNA binding protein TLS is translocated to dendritic spines by mGluR5 activation and regulates spine morphology
    Ritsuko Fujii
    Osaka Bioscience Institute, Suita, Osaka 565 0874, Japan
    Curr Biol 15:587-93. 2005
  6. ncbi Delocalization of the multifunctional RNA splicing factor TLS/FUS in hippocampal neurones: exclusion from the nucleus and accumulation in dendritic granules and spine heads
    Agnès Belly
    Laboratoire Neurodégénérescence et Plasticité, Université Joseph Fourier and INSERM EMI 0108, Pavillon de Neurologie, Centre Hospitalier Universitaire, F 38043 Grenoble Cedex 9, France
    Neurosci Lett 379:152-7. 2005
  7. ncbi Fusion of CHOP to a novel RNA-binding protein in human myxoid liposarcoma
    A Crozat
    Department of Medicine, NYU Medical Center, New York 10016
    Nature 363:640-4. 1993
  8. ncbi TLS, EWS and TAF15: a model for transcriptional integration of gene expression
    Warren J Law
    Manitoba Institute of Cell Biology and the University of Manitoba, 675 McDermot Avenue, Winnipeg, MB, Canada
    Brief Funct Genomic Proteomic 5:8-14. 2006
  9. pmc TLS/FUS, a pro-oncogene involved in multiple chromosomal translocations, is a novel regulator of BCR/ABL-mediated leukemogenesis
    D Perrotti
    Department of Microbiology and Immunology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA
    EMBO J 17:4442-55. 1998
  10. pmc hTAF(II)68, a novel RNA/ssDNA-binding protein with homology to the pro-oncoproteins TLS/FUS and EWS is associated with both TFIID and RNA polymerase II
    A Bertolotti
    Institut de Genetique et de Biologie Moleculaire et Cellulaire CNRS INSERM ULP, Illkirch, France
    EMBO J 15:5022-31. 1996

Scientific Experts

Detail Information

Publications142 found, 100 shown here

  1. ncbi Gene expression profile identifies a rare epithelioid variant case of pleomorphic liposarcoma carrying FUS-CHOP transcript
    L De Cecco
    FIRC Institute for Molecular Oncology Foundation, IFOM, Milano, Italy
    Histopathology 46:334-41. 2005
    ..Pleomorphic liposarcoma is a very rare variant of liposarcoma defined morphologically by the presence of pleomorphic lipoblasts showing peculiar epithelial-like features that can be confused with primary or metastatic carcinoma...
  2. ncbi TLS facilitates transport of mRNA encoding an actin-stabilizing protein to dendritic spines
    Ritsuko Fujii
    Osaka Bioscience Institute, Suita, Osaka 565 0874, Japan
    J Cell Sci 118:5755-65. 2005
    ..Our results demonstrate that TLS associates with mRNA encoding an actin-related protein and may be involved in actin reorganization in spines...
  3. pmc Abundant FUS-immunoreactive pathology in neuronal intermediate filament inclusion disease
    Manuela Neumann
    Institute of Neuropathology, University Hospital of Zurich, Zurich, Switzerland
    Acta Neuropathol 118:605-16. 2009
    ..No mutation in the FUS gene was identified in a single case with DNA available. These findings suggest that FUS may play an important role in the pathogenesis of NIFID...
  4. ncbi FUS-immunoreactive inclusions are a common feature in sporadic and non-SOD1 familial amyotrophic lateral sclerosis
    Han Xiang Deng
    Division of Neuromuscular Medicine, Davee Department of Neurology and Clinical Neurosciences, Chicago, IL 60611, USA
    Ann Neurol 67:739-48. 2010
    ..The pathogenic mechanism of the mutant FUS-mediated ALS and potential roles of FUS in non-FUS ALS remain to be investigated...
  5. ncbi The RNA binding protein TLS is translocated to dendritic spines by mGluR5 activation and regulates spine morphology
    Ritsuko Fujii
    Osaka Bioscience Institute, Suita, Osaka 565 0874, Japan
    Curr Biol 15:587-93. 2005
    ..Our results indicate that TLS participates in mRNA sorting to the dendritic spines induced by mGluR5 activation and regulates spine morphology to stabilize the synaptic structure...
  6. ncbi Delocalization of the multifunctional RNA splicing factor TLS/FUS in hippocampal neurones: exclusion from the nucleus and accumulation in dendritic granules and spine heads
    Agnès Belly
    Laboratoire Neurodégénérescence et Plasticité, Université Joseph Fourier and INSERM EMI 0108, Pavillon de Neurologie, Centre Hospitalier Universitaire, F 38043 Grenoble Cedex 9, France
    Neurosci Lett 379:152-7. 2005
    ..The apparent removal of TLS from the nucleus might result in specific patterns of mRNA transcription or splicing in hippocampal neurones. TLS may also contribute to steering, anchoring or regulating mRNAs at synaptic sites...
  7. ncbi Fusion of CHOP to a novel RNA-binding protein in human myxoid liposarcoma
    A Crozat
    Department of Medicine, NYU Medical Center, New York 10016
    Nature 363:640-4. 1993
    ..In TLS-CHOP the RNA-binding domain of TLS is replaced by the DNA-binding and leucine zipper dimerization domain of CHOP. Targeting of a conserved effector domain of RNA-binding proteins to DNA may play a role in tumour formation...
  8. ncbi TLS, EWS and TAF15: a model for transcriptional integration of gene expression
    Warren J Law
    Manitoba Institute of Cell Biology and the University of Manitoba, 675 McDermot Avenue, Winnipeg, MB, Canada
    Brief Funct Genomic Proteomic 5:8-14. 2006
    ....
  9. pmc TLS/FUS, a pro-oncogene involved in multiple chromosomal translocations, is a novel regulator of BCR/ABL-mediated leukemogenesis
    D Perrotti
    Department of Microbiology and Immunology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA
    EMBO J 17:4442-55. 1998
    ..Together, these results suggest that FUS might function as a regulator of BCR/ABL leukemogenesis, promoting growth factor independence and preventing differentiation via modulation of cytokine receptor expression...
  10. pmc hTAF(II)68, a novel RNA/ssDNA-binding protein with homology to the pro-oncoproteins TLS/FUS and EWS is associated with both TFIID and RNA polymerase II
    A Bertolotti
    Institut de Genetique et de Biologie Moleculaire et Cellulaire CNRS INSERM ULP, Illkirch, France
    EMBO J 15:5022-31. 1996
    ..Moreover, we demonstrate that hTAF(II)68 co-purifies also with the human RNA polymerase II and can enter the preinitiation complex together with Pol II...
  11. ncbi Myosin-Va facilitates the accumulation of mRNA/protein complex in dendritic spines
    Atsushi Yoshimura
    Osaka Bioscience Institute, Suita, Osaka 565 0874, Japan
    Curr Biol 16:2345-51. 2006
    ..Our results demonstrate that myosin-Va facilitates the transport of TLS-containing mRNP complexes in spines and may function in synaptic plasticity through Ca2+ signaling...
  12. ncbi TLS (FUS) binds RNA in vivo and engages in nucleo-cytoplasmic shuttling
    H Zinszner
    Skirball Institute of Biomolecular Medicine, the Deparment of Medicine, NYU Medical Center, New York 10016, USA
    J Cell Sci 110:1741-50. 1997
    ..These findings are discussed in the context of the role altered forms of TLS play in cellular transformation...
  13. ncbi RNA splicing mediated by YB-1 is inhibited by TLS/CHOP in human myxoid liposarcoma cells
    Timothy B Rapp
    Department of Orthopaedics and Sports Medicine, School of Medicine, University of Washington, Seattle 98108, USA
    J Orthop Res 20:723-9. 2002
    ..When considered in conjunction with studies on other sarcoma fusion proteins, these data suggest that aberrant RNA splicing may be a common feature of human sarcomas...
  14. ncbi FUS pathology in basophilic inclusion body disease
    David G Munoz
    Division of Pathology, Department of Laboratory Medicine and Pathobiology, Room 2 097 Cardinal Carter, St Michael s Hospital, University of Toronto, 30 Bond Street, Toronto, ON M5B 1W8, Canada
    Acta Neuropathol 118:617-27. 2009
    ..The consistent involvement of motorneurons in BIBD indicates that the association of FTLD and MND/ALS can occur on a FUS or TDP-43 pathological substrate...
  15. pmc Frequency of ubiquitin and FUS-positive, TDP-43-negative frontotemporal lobar degeneration
    Harro Seelaar
    Department of Neurology, Erasmus MC, University Medical Center Rotterdam, Room Hs 611, s Gravendijkwal 230, 3015 CE Rotterdam, The Netherlands
    J Neurol 257:747-53. 2010
    ..The existence of this pathological subtype can be predicted with reasonable certainty by age at onset <or=40 years, negative family history, bvFTD and caudate atrophy on MRI...
  16. ncbi Expression patterns of the human sarcoma-associated genes FUS and EWS and the genomic structure of FUS
    P Aman
    Department of Clinical Genetics, University Hospital of Lund, Sweden
    Genomics 37:1-8. 1996
    ..These observations indicate that FUS and EWS belong to the housekeeping type of genes. This view is supported by the presence of the housekeeping gene type of promoter region in both genes...
  17. ncbi Fusion of the EWS and CHOP genes in myxoid liposarcoma
    I Panagopoulos
    Department of Clinical Genetics, Lund University Hospital, Sweden
    Oncogene 12:489-94. 1996
    ....
  18. ncbi Fus deficiency in mice results in defective B-lymphocyte development and activation, high levels of chromosomal instability and perinatal death
    G G Hicks
    Manitoba Institute of Cell Biology and the University of Manitoba, Winnipeg, Canada
    Nat Genet 24:175-9. 2000
    ..The involvement of a nuclear riboprotein in these processes in vivo indicates that Fus is important in genome maintenance...
  19. ncbi An in vitro enzymatic assay coupled to proteomics analysis reveals a new DNA processing activity for Ewing sarcoma and TAF(II)68 proteins
    Olivier Guipaud
    Commissariat a l Energie Atomique, Departement de Radiobiologie et Radiopathologie, Fontenay aux Roses, France
    Proteomics 6:5962-72. 2006
    ..This common activity suggests a role for TET proteins and PSF in genome plasticity control...
  20. ncbi FUS/ERG gene fusions in Ewing's tumors
    Danielle C Shing
    Medical Research Council Cancer Cell Unit, Hutchison MRC Research Centre, Hills Road, Cambridge CB2 2XZ, UK
    Cancer Res 63:4568-76. 2003
    ..Our data provide additional evidence that the transactivation domains of the TET family of RNA-binding proteins (such as EWS and FUS) are interchangeable, and suggests a novel mechanism of oncogenesis in Ewing's tumors...
  21. ncbi Characterization of a new brain-specific isoform of the EWS oncoprotein
    T Melot
    Laboratoire de Pathologie Moléculaire des Cancers, INSERM U509, Paris, France
    Eur J Biochem 268:3483-9. 2001
    ..The phylogenetic conservation and relationship to neural differentiation strongly suggests an important functional role for this exon...
  22. ncbi Expression of the FUS-CHOP fusion protein in primary mesenchymal progenitor cells gives rise to a model of myxoid liposarcoma
    Nicolò Riggi
    Division of Experimental Pathology, Institute of Pathology, University of Lausanne, Lausanne, Switzerland
    Cancer Res 66:7016-23. 2006
    ..Taken together, our observations suggest that expression of FUS-CHOP may be the initiating event in myxoid liposarcoma pathogenesis, and that MPCs may constitute one cell type from which these tumors originate...
  23. ncbi A topogenic role for the oncogenic N-terminus of TLS: nucleolar localization when transcription is inhibited
    H Zinszner
    Department of Medicine, Skirball Institute of Biomolecular Medicine, NYU Medical Center, New York, NY 10016, USA
    Oncogene 14:451-61. 1997
    ....
  24. ncbi Genomic structure of the human RBP56/hTAFII68 and FUS/TLS genes
    F Morohoshi
    Radiobiology Division, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Gene 221:191-8. 1998
    ....
  25. ncbi Fusion of the dominant negative transcription regulator CHOP with a novel gene FUS by translocation t(12;16) in malignant liposarcoma
    T H Rabbitts
    MRC Laboratory of Molecular Biology, Cambridge, UK
    Nat Genet 4:175-80. 1993
    ..The data also indicate the importance of transcription disruption in the pathogenesis of solid tumours...
  26. pmc The myxoid/round cell liposarcoma fusion oncogene FUS-DDIT3 and the normal DDIT3 induce a liposarcoma phenotype in transfected human fibrosarcoma cells
    Katarina Engström
    Department of Oncology, Lundberg Laboratory for Cancer Research, Sahlgrenska University Hospital, Gothenburg, Sweden
    Am J Pathol 168:1642-53. 2006
    ..In addition, development of lipoblasts and the typical MLS/RCLS capillary network could be an effect of the DDIT3 transcription factor partner of the fusion oncogene...
  27. ncbi Identification of genes differentially expressed in TLS-CHOP carrying myxoid liposarcomas
    S Thelin-Järnum
    Department of Clinical Genetics, University Hospital, Lund, Sweden
    Int J Cancer 83:30-3. 1999
    ..MLAT1, 2 and 6 show high similarity to glia-derived nexin, neuronatin and the RET oncogene, respectively, all normally involved in development of tissues of neural origin. MLAT3 to MLAT5 represent new genes...
  28. ncbi Human POMp75 is identified as the pro-oncoprotein TLS/FUS: both POMp75 and POMp100 DNA homologous pairing activities are associated to cell proliferation
    P Bertrand
    CEA, DSV, DRR, CNRS UMR 217, Fontenay aux Roses, France
    Oncogene 18:4515-21. 1999
    ..Possible relationship between cell proliferation, response to DNA damage and DNA homologous pairing activity of the pro-oncoprotein TLS/FUS are discussed...
  29. ncbi Abnormal expression of cell cycle regulators in FUS-CHOP carrying liposarcomas
    Anita Olofsson
    Lundberg Laboratory for Cancer Research, Department of Pathology, Sahlgrenska University Hospital, Gula straket 8, SE 413 45 Gothenburg, Sweden
    Int J Oncol 25:1349-55. 2004
    ..We conclude that deregulation of G1 controlling proteins is common in MLS/RCLS and that aberrant expression of these proteins is of importance in the pathogenesis of this tumor type...
  30. ncbi The myxoid liposarcoma specific TLS-CHOP fusion protein localizes to nuclear structures distinct from PML nuclear bodies
    Sofia Thelin-Järnum
    The Lundberg Laboratory for Cancer Research, Department of Pathology, Goteborg University, Gothenburg, Sweden
    Int J Cancer 97:446-50. 2002
    ..Transfection of TLS-CHOP induced a rapid disappearance of PCNA. TLS-CHOP may disturb the nuclear machinery by binding and sequestering important factors from their natural sites...
  31. ncbi The myxoid liposarcoma FUS-DDIT3 fusion oncoprotein deregulates NF-kappaB target genes by interaction with NFKBIZ
    M Goransson
    Lundberg Laboratory for Cancer Research LLCR, Department of Pathology, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
    Oncogene 28:270-8. 2009
    ..Similar mechanisms may be a part of the transformation process in other tumor types carrying FUS, EWSR1 and TAF15 containing fusion oncogenes...
  32. ncbi The transcriptional repressor ZFM1 interacts with and modulates the ability of EWS to activate transcription
    D Zhang
    Department of Molecular Genetics, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Biol Chem 273:18086-91. 1998
    ..The association of ZFM1 with these proteins implies that one normal cellular function for ZFM1 may be to negatively modulate transcription of target genes coordinated by these cofactors...
  33. pmc Cabeza, a Drosophila gene encoding a novel RNA binding protein, shares homology with EWS and TLS, two genes involved in human sarcoma formation
    D T Stolow
    Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Nucleic Acids Res 23:835-43. 1995
    ..Therefore, it appears that these genes constitute a new sub-family of RNA binding proteins...
  34. ncbi FUS expression alters the differentiation response to all-trans retinoic acid in NB4 and NB4R2 cells
    Elisabeth J Walsby
    Department of Haematology, School of Medicine, Cardiff University, Cardiff, UK
    Br J Haematol 139:94-7. 2007
    ....
  35. ncbi TLS-GFP cannot rescue mRNP formation near spines and spine phenotype in TLS-KO
    Ritsuko Fujii
    Waseda Olympus Bioscience Research Institute, Biopolis, Singapore
    Neuroreport 20:57-61. 2009
    ..Our results indicate that formation of TLS-Nd1-L mRNA complex clusters, presumable mRNA pools for the local protein synthesis in the spines, was impaired in TLS-deficient neurons...
  36. ncbi Beta-catenin interacts with the FUS proto-oncogene product and regulates pre-mRNA splicing
    Satoshi Sato
    Chemotherapy Division and Cancer Proteomics Project, National Cancer Center Research Institute, Tokyo, Japan
    Gastroenterology 129:1225-36. 2005
    ..In this study, we used a proteomics approach to obtain further insight into the functional properties of nuclear beta-catenin...
  37. ncbi Oncogenic TLS/ERG and EWS/Fli-1 fusion proteins inhibit RNA splicing mediated by YB-1 protein
    H A Chansky
    Department of Orthopedics, University of Washington School of Medicine, Seattle, Washington 98195, USA
    Cancer Res 61:3586-90. 2001
    ..Together, these results suggest that TLS and EWS fusion proteins may contribute to malignant transformation through disruption of RNA splicing mediated by TLS- and EWS-binding proteins such as YB-1...
  38. pmc Male sterility and enhanced radiation sensitivity in TLS(-/-) mice
    M Kuroda
    Skirball Institute of Biomolecular Medicine, the Departments of Medicine, Cell Biology and the Kaplan Cancer Center, NYU Medical Center, New York, NY 10016, USA
    EMBO J 19:453-62. 2000
    ..These results are consistent with a role for TLS in homologous DNA pairing and recombination...
  39. ncbi Fusion genes in angiomatoid fibrous histiocytoma
    Karolin H Hallor
    Department of Clinical Genetics, University Hospital, Lund, Sweden
    Cancer Lett 251:158-63. 2007
    ..Nonetheless, RT-PCR for these fusion transcripts remains a valuable diagnostic adjunct in the distinction between AFH and other soft tissue tumors or metastases that may simulate it...
  40. ncbi Clinicopathologic and molecular genetic characterization of low-grade fibromyxoid sarcoma, and cloning of a novel FUS/CREB3L1 fusion gene
    Fredrik Mertens
    Department of Clinical Genetics, Lund University Hospital, Lund, Sweden
    Lab Invest 85:408-15. 2005
    ..Taken together, the results indicate that virtually all LGFMS are characterized by a chimeric FUS/CREB3L2 gene, and that rare cases may display a variant FUS/CREB3L1 fusion...
  41. ncbi Skeletal metastases in myxoid liposarcoma: an unusual pattern of distant spread
    Joseph H Schwab
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Ann Surg Oncol 14:1507-14. 2007
    ..Anecdotal evidence, mainly supported by isolated case reports, suggests that a subset of these patients also develop bone metastasis, especially within the spine, which was previously under-appreciated...
  42. ncbi [Detection of FUS-CHOP fusion gene in paraffin-embedded tissues and its clinicopathologic significance for myxoid/round cell liposarcomas]
    Hua Xiang
    Department of Pathology, Cancer Hospital, Fudan University, Shanghai 200032, China
    Zhonghua Bing Li Xue Za Zhi 34:28-32. 2005
    ..To explore the feasibility of detecting FUS-CHOP fusion gene in formalin-fixed, paraffin-embedded tissue and its application in the diagnosis and differential diagnosis of myxoid/round cell liposarcomas (MRCLs)...
  43. ncbi Translocation-positive low-grade fibromyxoid sarcoma: clinicopathologic and molecular analysis of a series expanding the morphologic spectrum and suggesting potential relationship to sclerosing epithelioid fibrosarcoma: a study from the French Sarcoma Gro
    Louis Guillou
    University Institute of Pathology, Lausanne, Switzerland
    Am J Surg Pathol 31:1387-402. 2007
    ..The presence of epithelioid cells and fusion transcripts in both LGFMS and a subset of sclerosing epithelioid fibrosarcoma suggest that these neoplasms might be related...
  44. pmc The oncogenic TLS-ERG fusion protein exerts different effects in hematopoietic cells and fibroblasts
    Junhui Zou
    Department of Orthopedics, University of Washington, Seattle 98195, USA
    Mol Cell Biol 25:6235-46. 2005
    ..Taken together, these results suggest that the oncogenic TLS-ERG fusion protein transforms hematopoietic cells and fibroblasts via different pathways...
  45. ncbi TLS-ERG leukemia fusion protein deregulates cyclin-dependent kinase 1 and blocks terminal differentiation of myeloid progenitor cells
    Jing Pan
    Departments of Orthopedics and Medicine Hematology, University of Washington, 1660 South Columbian Way, GMR 151, Seattle, WA 98108
    Mol Cancer Res 6:862-72. 2008
    ....
  46. ncbi Pleomorphic angiomatoid fibrous histiocytoma: a case confirmed by fluorescence in situ hybridization analysis for EWSR1 rearrangement
    Ilan Weinreb
    Department of Pathology and Department of Laboratory Medicine and Pathobiology, University Health Network, Toronto, Ontario, Canada
    J Cutan Pathol 35:855-60. 2008
    ..Pleomorphic AFH should be included in the differential diagnosis of atypical mesenchymal tumors of skin and superficial subcutis and molecular testing may prove helpful in this regard...
  47. ncbi The proto-oncoprotein SYT interacts with SYT-interacting protein/co-activator activator (SIP/CoAA), a human nuclear receptor co-activator with similarity to EWS and TLS/FUS family of proteins
    Michela Perani
    Section of Molecular Carcinogenesis, Institute of Cancer Research and Cancer Research UK Centre for Cancer Therapeutics, Institute of Cancer Research, Sutton, Surrey, SM2 5NG, United Kingdom
    J Biol Chem 280:42863-76. 2005
    ..The stimulation is strongly reduced if the N-terminal region of hBRM/BRG1 (amino acids 1-211) is deleted. This region encompasses the SNF11 binding domain (amino acids 156-211), which interacts specifically with SYT in vivo and in vitro...
  48. ncbi Myxoid liposarcoma with cartilaginous differentiation: identification of the same type II TLS-CHOP fusion gene transcript in both lipogenic and chondroid components
    Yu Ching Wei
    Department of Pathology, Kaohsiung Medical Center, Chang Gung University Hospital College of Medicine, Chang Gung Memorial Hospital, 123 Ta Pei Road, Niao Sung Hsiang, Kaohsiung County 833, Taiwan
    Appl Immunohistochem Mol Morphol 15:477-80. 2007
    ..Our case confirms the actual existence of MLS with cartilaginous differentiation and the neoplastic nature of chondroid component...
  49. ncbi Detection of TLS/FUS-CHOP fusion transcripts in a case of oral liposarcoma
    Elena Riet Correa Rivero
    Department of Oral Pathology, School of Dentistry, University of Sao Paulo, 05508 900 Sao Paulo, Brazil
    Ann Diagn Pathol 10:36-8. 2006
    ....
  50. pmc Inconspicuous insertion 22;12 in myxoid/round cell liposarcoma accompanied by the secondary structural abnormality der(16)t(1;16)
    Nathan C Birch
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska, USA
    J Mol Diagn 5:191-4. 2003
    ....
  51. ncbi Updates on the cytogenetics and molecular genetics of bone and soft tissue tumors: liposarcoma
    Avery A Sandberg
    Department of DNA Diagnostics, St Joseph s Hospital and Medical Center, 350 West Thomas Road, Phoenix, AZ 85013, USA
    Cancer Genet Cytogenet 155:1-24. 2004
  52. ncbi The prooncoprotein EWS binds calmodulin and is phosphorylated by protein kinase C through an IQ domain
    J C Deloulme
    University of Washington, Department of Pharmacology, Seattle, Washington 98195, USA
    J Biol Chem 272:27369-77. 1997
    ..These data suggest that PKC may regulate interactions of EWS and other RNA-binding proteins with their RNA targets and that IQ domains may provide a regulatory link between Ca2+ signal transduction pathways and RNA processing...
  53. ncbi Characteristic sequence motifs located at the genomic breakpoints of the translocation t(12;16) and t(12;22) in myxoid liposarcoma
    Hua Xiang
    Department of Pathology, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou
    Pathology 40:547-52. 2008
    ..To analyse the characteristic sequence motifs around genomic breakpoints of translocations, t(12;16) and t(12;22), and to study the mechanisms underlying these chromosomal translocations in myxoid liposarcomas (MLS)...
  54. ncbi TLS-CHOP target gene DOL54 expression in liposarcomas and malignant fibrous histiocytomas
    Hideharu Domoto
    Department of Pathology, Tokyo Medical University, Tokyo, Japan
    Pathol Int 52:497-500. 2002
    ..In this manner, M-LPS/RC-LPS and MFH lesions may share tumorigenic characteristics, resulting from the unscheduled expression of DOL54...
  55. ncbi Translin binds to the sequences adjacent to the breakpoints of the TLS and CHOP genes in liposarcomas with translocation t(12;6)
    T Hosaka
    Institute for Frontier Medical Sciences, Kyoto University, Shogoin, Japan
    Oncogene 19:5821-5. 2000
    ..Considering the high incidence and specific binding property, the presence of Translin binding motif may be one of the important determinants for the location of breakpoints in the TLS and CHOP genes in liposarcomas...
  56. pmc Association of SARFH (sarcoma-associated RNA-binding fly homolog) with regions of chromatin transcribed by RNA polymerase II
    D Immanuel
    Skirball Institute of Biomolecular Medicine, Department of Medicine, New York University Medical Center, New York 10016, USA
    Mol Cell Biol 15:4562-71. 1995
    ..We conclude that SARFH and, by homology, EWS and TLS participate in a function common to the expression of most genes transcribed by RNA Pol II...
  57. ncbi The fragile X mental retardation protein binds and regulates a novel class of mRNAs containing U rich target sequences
    L Chen
    Department of Pharmacology, Cornell University, Weill Medical College, 1300 York Ave, LC 522, 10021, New York, NY, USA
    Neuroscience 120:1005-17. 2003
    ..However, levels of two target-encoded proteins, an L-type calcium channel subunit and MAP1B, were downregulated in specific brain regions suggesting a defect in the expression of target-encoded proteins in fragile X syndrome...
  58. ncbi Myxoid liposarcoma confirmed by TLS/FUS-CHOP fusion transcripts
    Yau Li Huang
    Department of Dermatology, Chang Gung Memorial Hospital, 199 Tung Hwa North Road, Taipei 105, Taiwan
    Dermatol Surg 29:980-1. 2003
    ....
  59. ncbi Myxoid liposarcoma with adipocytic maturation: detection of TLS/CHOP fusion gene transcript
    Hirofumi Nakanishi
    Departments of Orthopedic Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan
    Diagn Mol Pathol 13:92-6. 2004
    ..Molecular analysis revealed that type 1 TLS/ CHOP fusion gene transcript, characteristic of myxoid/round cell liposarcoma, was detected in both areas...
  60. ncbi Human 75-kDa DNA-pairing protein is identical to the pro-oncoprotein TLS/FUS and is able to promote D-loop formation
    H Baechtold
    Basel Institute for Immunology, Grenzacherstrasse 487, CH 4005 Basel, Switzerland
    J Biol Chem 274:34337-42. 1999
    ..Interestingly, the oncogenic fusion form TLS-CHOP is not able to promote DNA pairing. These data suggest a possible role for hPOMp75/TLS in maintenance of genomic integrity...
  61. ncbi [AML(M7) associated with t(16;21)(p11;q22) showing relapse after unrelated bone marrow transplantation and disappearance of TLS/FUS-ERG mRNA]
    Y Fukushima
    Department of Pediatrics, Matsushita Memorial Hospital
    Rinsho Ketsueki 42:502-6. 2001
    ..We consider that U-BMT is a promising treatment for t(16;21)(p11;q22) AML. However, an intensified conditioning regimen or modification of GVHD prophylaxis is needed...
  62. ncbi Expression of DOL54 is not restricted to myxoid liposarcomas with the FUS-DDIT3 chimera but is found in various sarcomas
    Ioannis Panagopoulos
    Department of Clinical Genetics, Lund University Hospital, Lund, Sweden
    Oncol Rep 12:107-10. 2004
    ..The results of our study clearly show that expression of DOL54 is not only a characteristic feature of MLS with the FUS-DDIT3 chimera but that this is a frequent finding also in various other sarcomas...
  63. ncbi The COP/DET/FUS proteins-regulators of eukaryotic growth and development
    C Schwechheimer
    Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06520 8104, USA
    Semin Cell Dev Biol 11:495-503. 2000
    ....
  64. pmc Mutant FUS proteins that cause amyotrophic lateral sclerosis incorporate into stress granules
    Daryl A Bosco
    Department of Neurology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
    Hum Mol Genet 19:4160-75. 2010
    ..These findings demonstrate a potential link between FUS mutations and cellular pathways involved in stress responses that may be relevant to altered motor neuron homeostasis in ALS...
  65. pmc Extensive FUS-immunoreactive pathology in juvenile amyotrophic lateral sclerosis with basophilic inclusions
    Eric J Huang
    Department of Pathology, University of California, San Francisco, CA, USA
    Brain Pathol 20:1069-76. 2010
    ..Furthermore, our study represents the first detailed characterizations of neuropathological findings in rapidly progressive juvenile ALS patients with a mutation in the FUS/TLS gene...
  66. ncbi Novel FUS/TLS mutations and pathology in familial and sporadic amyotrophic lateral sclerosis
    Christopher Hewitt
    Academic Unit of Neurology, University of Sheffield, Medical School, Beech Hill Road, Sheffield S10 2RX, England
    Arch Neurol 67:455-61. 2010
    ..To determine the frequency of and clinicopathologic phenotypes associated with FUS/TLS mutations in a large cohort of amyotrophic lateral sclerosis (ALS) cases from the north of England...
  67. pmc Expression of human FUS protein in Drosophila leads to progressive neurodegeneration
    YanBo Chen
    National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Science and Peking Union Medical College, Tsinghua University, Beijing, China
    Protein Cell 2:477-86. 2011
    ..The transgenic flies expressing the hFUS gene recapitulate key features of FUS proteinopathy, representing the first stable animal model for this group of devastating diseases...
  68. pmc Induced ncRNAs allosterically modify RNA-binding proteins in cis to inhibit transcription
    Xiangting Wang
    Howard Hughes Medical Institute
    Nature 454:126-30. 2008
    ....
  69. pmc DNA replication to aid somatic hypermutation
    Zhenming Xu
    Center for Immunology, School of Medicine, University of California, Irvine, CA 92697 4120, USA
    Adv Exp Med Biol 596:111-27. 2007
  70. pmc Topography of FUS pathology distinguishes late-onset BIBD from aFTLD-U
    Edward B Lee
    Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA Translational Neuropathology Research Laboratory, 605B Stellar Chance Laboratories, 422 Curie Blvd, Philadelphia, PA 19104, USA Department of Pathology and Laboratory Medicine, Philadelphia, PA, USA
    Acta Neuropathol Commun 1:1-11. 2013
    ..In this study, we report the clinical and pathologic features of three cases of aFTLD-U and two cases of late-onset BIBD with an emphasis on the anatomic distribution of FUS inclusions...
  71. ncbi Investigating FUS variation in Parkinson's disease
    Catherine Labbé
    Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA
    Parkinsonism Relat Disord 20:S147-9. 2014
    ..These findings and previous studies have shown that variants within the FUS gene are not a common cause of PD or ET, in comparison to their role in ALS. ..
  72. pmc IGF1 is a common target gene of Ewing's sarcoma fusion proteins in mesenchymal progenitor cells
    Luisa Cironi
    Division of Experimental Pathology, Institute of Pathology CHUV, University of Lausanne, Lausanne, Switzerland
    PLoS ONE 3:e2634. 2008
    ..ESFT are dependent on insulin-like growth factor-1 (IGF-1) for growth and survival and recent evidence suggests that mesenchymal progenitor/stem cells constitute a candidate ESFT origin...
  73. pmc Gene translocations in musculoskeletal neoplasms
    Balaji Krishnan
    Department of Orthopaedic Surgery, University of Minnesota Twin Cities, 420 Delaware Street SE, MMC 492, Minneapolis, MN 55455, USA
    Clin Orthop Relat Res 466:2131-46. 2008
    ....
  74. ncbi FUS is not dysregulated by the spinal bulbar muscular atrophy androgen receptor polyglutamine repeat expansion
    Pietro Fratta
    Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, London, UK
    Neurobiol Aging 34:1516.e17-9. 2013
    ..We have investigated this possibility by using a well-established mouse model of SBMA and our analysis of primary motor neuron cultures, spinal cords, and microdissected motor neurons show no evidence for FUS dysregulation...
  75. ncbi TAR DNA binding protein-43 and fused in sarcoma/translocated in liposarcoma protein in two neurodegenerative diseases
    Xin ning WANG
    Department of Neurology, PUMC Hospital, CAMS and PUMC, Beijing 100730, China
    Zhongguo Yi Xue Ke Xue Yuan Xue Bao 34:286-92. 2012
    ..Although the interactions between ALS and FTD remain unknown, it is speculated that TDP-43 and FUS/TLS-associated neurodegenerative diseases may share similar pathogenesis...
  76. ncbi [Research in amyotrophic lateral sclerosis: what is new in 2009?]
    P F Pradat
    CHU Pitie Salpetriere, AP HP, Paris Cedex 13, France
    Rev Neurol (Paris) 166:683-98. 2010
    ..Therapeutic trials have been performed or are currently ongoing in Europe and North America. Their results have not yet been published...
  77. pmc Tyrosine Phosphorylation in the C-Terminal Nuclear Localization and Retention Signal (C-NLS) of the EWS Protein
    Ruzanna P Leemann-Zakaryan
    Department of Biochemistry, University of Zurich, Winterthurerstrase 190, 8057 Zurich, Switzerland
    Sarcoma 2011:218483. 2011
    ....
  78. pmc Pathological heterogeneity in amyotrophic lateral sclerosis with FUS mutations: two distinct patterns correlating with disease severity and mutation
    Ian R A Mackenzie
    Department of Pathology, University of British Columbia and Vancouver General Hospital, Vancouver, BC V5Z 1M9, Canada
    Acta Neuropathol 122:87-98. 2011
    ..Comparison with the neuropathology of cases of frontotemporal lobar degeneration with FUS-ir pathology showed significant differences and suggests that FUS mutations are associated with a distinct pathobiology...
  79. ncbi Low-grade fibromyxoid sarcoma: a brief review
    Stephen E Vernon
    Department of Pathology, University of Miami JMH, Miami, Fla 33136, USA
    Arch Pathol Lab Med 130:1358-60. 2006
    ..Because of similar clinical behavior and the common cytogenetic abnormality, some authors prefer to consider both lesions as a single entity within the spectrum of low-grade sarcomas...
  80. ncbi Acceleration of TDP43 and FUS/TLS protein expressions in the preconditioned hippocampus following repeated transient ischemia
    Miao Sun
    Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan Department of Neurology, Shengjing Hospital, China Medical University, Shenyang, China
    J Neurosci Res 92:54-63. 2014
    ..These data show that ischemic preconditioning offers a way to induce endogenous neuroprotection and neurogenesis in gerbils, with TDP43, FUS/TLS, and HSP70 involved in this function...
  81. pmc TLS-ERG leukemia fusion protein inhibits RNA splicing mediated by serine-arginine proteins
    L Yang
    Medical Research Service, VA Puget Sound Health Care System, Seattle, Washington 98108, USA
    Mol Cell Biol 20:3345-54. 2000
    ..These results suggest that TLS fusion proteins may lead to cellular abnormalities by interfering with the splicing of important cellular regulators...
  82. ncbi [Detection of fusion genes resulting from chromosome abnormalities in childhood acute lymphoblastic leukemia]
    Jun He
    Jiangsu Institute of Hematology, The First Hospital, Soochow University, Suzhou, Jiangsu, PR China
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 22:551-3. 2005
    ..To detect the expression of the fusion genes resulting from chromosome abnormalities in childhood acute lymphoblastic leukemia(ALL) and its conformity to WHO classification...
  83. ncbi Molecular variability of TLS-CHOP structure shows no significant impact on the level of adipogenesis: a comparative ultrastructural and RT-PCR analysis of 14 cases of myxoid/round cell liposarcomas
    Hsuan Ying Huang
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Ultrastruct Pathol 27:217-26. 2003
    ..These findings cannot substantiate the hypothesis that the molecular variability of fusion transcripts has a biological impact on adipogenesis of MLS, and other factors might be implicated in their level of differentiation...
  84. ncbi Fusion of the FUS and ATF1 genes in a large, deep-seated angiomatoid fibrous histiocytoma
    Emad Raddaoui
    Department of Pathology, Scott and White Memorial Hospital and Clinic, Temple, TX 76508, USA
    Diagn Mol Pathol 11:157-62. 2002
    ..Because identical fusion of the and genes has been recently reported in another case of angiomatoid fibrous histiocytoma, fusion of these genes may be characteristic for at least a subset of these tumors...
  85. pmc The multifunctional FUS, EWS and TAF15 proto-oncoproteins show cell type-specific expression patterns and involvement in cell spreading and stress response
    Mattias K Andersson
    Lundberg Laboratory for Cancer Research, Department of Pathology, Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
    BMC Cell Biol 9:37. 2008
    ..In the present study, we investigated the expression and cellular localization of FET proteins in multiple human tissues and cell types...
  86. ncbi Localization of fused in sarcoma (FUS) protein to the post-synaptic density in the brain
    Naoya Aoki
    Dementia Project, Department of Dementia and Higher Brain Function, Tokyo Metropolitan Institute of Medical Science, 2 1 6 Kamikitazawa, Setagaya Ku, Tokyo, 156 8506, Japan
    Acta Neuropathol 124:383-94. 2012
    ..The increase in Alzheimer's disease (AD) is less remarkable but still significant. The dendritic localization of FUS and its increase in FTLD-TDP and AD may have some implication for the pathophysiology of neurodegenerative diseases...
  87. pmc The heritability and genetics of frontotemporal lobar degeneration
    J D Rohrer
    Dementia Research Centre, Institute of Neurology, Queen Square, London WC1N 3BG, UK
    Neurology 73:1451-6. 2009
    ..Frontotemporal lobar degeneration (FTLD) is a genetically and pathologically heterogeneous neurodegenerative disorder...
  88. ncbi Abundant FUS-immunoreactive pathology in the skin of sporadic amyotrophic lateral sclerosis
    Y Oketa
    Department of Neurology, Teikyo University Chiba Medical Center, Ichihara, Japan
    Acta Neurol Scand 128:257-64. 2013
    ..Also, FUS has been found in neuronal cytoplasmic inclusions in sporadic forms of ALS, suggesting that FUS has an important role in the neurodegeneration occurring in sporadic disease. However, there has been no study of FUS in ALS skin...
  89. ncbi FUS mutations in familial amyotrophic lateral sclerosis in the Netherlands
    Ewout J N Groen
    Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Heidelberglaan, Utrecht, The Netherlands
    Arch Neurol 67:224-30. 2010
    ..To assess the frequency of FUS mutations in 52 probands with familial amyotrophic lateral sclerosis (FALS) and to provide careful documentation of clinical characteristics...
  90. ncbi Specificity of fusion genes in adipocytic tumors
    Takahiro Kubo
    Department of Orthopaedics, Institute of Health Biosciences, University of Tokushima Graduate School, Tokushima 770 8503, Japan
    Anticancer Res 30:661-4. 2010
    ..However, the specificity of these fusion genes has not been established in a variety of adipocytic tumors...
  91. pmc Ebp1 sumoylation, regulated by TLS/FUS E3 ligase, is required for its anti-proliferative activity
    S M Oh
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Oncogene 29:1017-30. 2010
    ..Moreover, unsumoylated Ebp1 mutants fail to suppress E2F-1-regulated transcription, resulting in loss of its anti-proliferation activity. Hence, TLS-mediated sumoylation is required for Ebp1 transcriptional repressive activity...
  92. ncbi Temperature-dependent localization of TLS-CHOP to splicing factor compartments
    Melker Göransson
    Lundberg Laboratory for Cancer Research, Department of Pathology, Goteborg University, Gula straket 8, S 413 45 Gothenburg, Sweden
    Exp Cell Res 278:125-32. 2002
    ..Further, mutational analysis of the N-terminal part of green fluorescent protein-tagged TLS-CHOP identifies a region within the N-terminal required for colocalization with the splicing factor SC-35...
  93. pmc FUS pathology defines the majority of tau- and TDP-43-negative frontotemporal lobar degeneration
    Hazel Urwin
    UCL Institute of Neurology, London, UK
    Acta Neuropathol 120:33-41. 2010
    ..We identified three FTLD-UPS cases, which are negative for CHMP2B mutation, suggesting that the full complement of FTLD pathologies is yet to be elucidated...
  94. pmc Nuclear expression of FLT1 and its ligand PGF in FUS-DDIT3 carrying myxoid liposarcomas suggests the existence of an intracrine signaling loop
    Mattias K Andersson
    Lundberg Laboratory for Cancer Research, Department of Pathology, Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
    BMC Cancer 10:249. 2010
    ..We have previously identified FLT1 (VEGFR1) as a candidate downstream target gene of FUS-DDIT3. The aim of this study was to investigate expression of FLT1 and its ligands in MLS cells...
  95. ncbi [Two cases of acute myeloid leukemia with t(16;21)(p11;q22) and TLS/FUS-ERG fusion transcripts]
    Woong Rin Chang
    Department of Laboratory Medicine, Ajou University School of Medicine, Suwon, Korea
    Korean J Lab Med 29:390-5. 2009
    ..He was transferred to another hospital with no more follow-up. We suggest that the presence of t(16;21)(p11;q22) and/or TLS/FUS-ERG fusion transcripts has to be considered in cases of AML with erythrophagocytosis...
  96. ncbi Expression of the FUS domain restores liposarcoma development in CHOP transgenic mice
    Pedro Antonio Pérez-Mancera
    Instituto de Biologia Molecular y Celular del Cancer, Centro de Investigacion del Cancer, CSIC Universidad de Salamanca, Campus Unamuno 37007 Salamanca, Spain
    Oncogene 21:1679-84. 2002
    ..These results identify a new mechanism of tumor-associated fusion genes and might have impact beyond myxoid liposarcoma...
  97. pmc Fus gene mutations in familial and sporadic amyotrophic lateral sclerosis
    Rosa Rademakers
    Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA
    Muscle Nerve 42:170-6. 2010
    ..This study demonstrates that the phenotype with FUS mutations extends beyond classical ALS cases. Our findings suggest there are specific clinicogenetic correlations and provide the first detailed neuropathological description...
  98. ncbi TLS (translocated-in-liposarcoma) is a high-affinity interactor for steroid, thyroid hormone, and retinoid receptors
    C A Powers
    Division of Molecular Endocrinology, New York University Medical Center 10016, USA
    Mol Endocrinol 12:4-18. 1998
    ..The transactivation and RNA-binding properties of TLS and the nature of its interaction with nuclear receptors suggest a novel role in nuclear receptor function...
  99. ncbi Human translocation liposarcoma-CCAAT/enhancer binding protein (C/EBP) homologous protein (TLS-CHOP) oncoprotein prevents adipocyte differentiation by directly interfering with C/EBPbeta function
    G Adelmant
    Departments of Molecular Biology and Radiation Oncology, Henry Ford Health System, Detroit, Michigan 48202 3450, USA
    J Biol Chem 273:15574-81. 1998
    ..Moreover, they provide strong support for the thesis that a blockade to normal differentiation is an important aspect of the cancer process...
  100. ncbi Oncoprotein TLS interacts with serine-arginine proteins involved in RNA splicing
    L Yang
    Medical Research Service, Veterans Affairs Puget Sound Health Care System, Seattle, Washington 98108, USA
    J Biol Chem 273:27761-4. 1998
    ..Thus TLS translocations may alter RNA processing and play a role in malignant transformation...
  101. pmc Induction of a secreted protein by the myxoid liposarcoma oncogene
    M Kuroda
    Skirball Institute of Biomolecular Medicine, Departments of Medicine, Cell Biology, and the Kaplan Cancer Center, New York University Medical Center, New York, NY 10016, USA
    Proc Natl Acad Sci U S A 96:5025-30. 1999
    ..TLS-CHOP thus leads to the unscheduled expression of a gene that is normally associated with adipocytic differentiation...

Research Grants12

  1. Cellular and Animal Models of FUS Mutations in ALS
    Eric J Huang; Fiscal Year: 2013
    ..Once available, these models will serve as novel platforms to identify new therapeutic targets for diseases caused by FUS/TLS mutations. ..
  2. Regulation of transcription by the RNA-binding protein FUS
    Jacob C Schwartz; Fiscal Year: 2013
    ..Completion of this study will provide a list of genes regulated by FUS, solidify a mechanism for the RNA-directed recruitment of FUS and demonstrate how these interactions are required for FUS activity in cells. ..
  3. Investigating a Toxic Gain-of-Interaction Between FUS/TLS &Stress Granules
    DARYL ANGELA BOSCO; Fiscal Year: 2013
    ..These studies have the potential to reveal stress granules as biomarkers of ALS. ..
  4. Mechanisms of alternative splicing of pre-mRNA
    James L Manley; Fiscal Year: 2013
    ..Numerous studies have revealed that changes in alternative splicing occur during development and disease, and the proposed experiments will provide a mechanistic understanding for these changes. ..
  5. Analysis of the RNA-binding Protein FUS and Its Role in Neurodegenerative Disease
    Jacob C Schwartz; Fiscal Year: 2013
    ..abstract_text> ..
  6. Transcriptional coactivators and arginine methylation
    Jennifer Butler; Fiscal Year: 2004
    ..Finally, biochemical techniques will be used to identify proteins that preferentially interact with methylated TLS. This work has the potential to link CBP. ..
  7. Signaling pathways of HIPK2 in neuronal apoptosis
    Eric Huang; Fiscal Year: 2009
    ..Discoveries from this project will contribute to future design of HIPK2 inhibitors that can promote neuronal survival in injury and degenerative conditions. ..
  8. CHONDROGENESIS AND HISTONE MODIFICATION ENZYMES
    Liu Yang; Fiscal Year: 2007
    ....
  9. Molecular Mechanisms of Sensory Neurogenesis
    Eric Huang; Fiscal Year: 2006
    ..abstract_text> ..
  10. TLS and TLS Fusion Proteins in Leukemia
    Liu Yang; Fiscal Year: 2005
    ..It is envisioned that successful completion of this project will unveil potential therapeutic targets in the treatment of human leukemias characterized by the t(16;21) translocation. ..
  11. TRANSGENIC STUDIES OF AMYOTROPHIC LATERAL SCLEROSIS
    Han Xiang Deng; Fiscal Year: 2004
    ..To achieve this goal we propose to develop additional transgenic mouse lines that over express successively smaller fragments of SOD 1 polypeptide to determine the smallest segment of SOD 1 that causes ALS. ..
  12. MECHANISMS OF TRANSCRIPTIONAL REGULATION
    James Manley; Fiscal Year: 2006
    ..abstract_text> ..