oncogene proteins

Summary

Summary: Proteins coded by oncogenes. They include proteins resulting from the fusion of an oncogene and another gene (ONCOGENE PROTEINS, FUSION).

Top Publications

  1. ncbi Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism
    Vincenzo Bonifati
    Genetic Epidemiologic Unit, Department of Clinical Genetics, Department of Epidemiology and Biostatistics, Erasmus Medical Center Rotterdam, Post Office Box 1738, 3000 DR Rotterdam, Netherlands
    Science 299:256-9. 2003
  2. ncbi Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron
    Trude H Flo
    Institute for Systems Biology, Seattle, Washington 98103, USA
    Nature 432:917-21. 2004
  3. ncbi Neutrophil gelatinase-associated lipocalin (NGAL) as a biomarker for acute renal injury after cardiac surgery
    Jaya Mishra
    Division of Nephrology and Hypertension, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229 3039, USA
    Lancet 365:1231-8. 2005
  4. ncbi Identification of neutrophil gelatinase-associated lipocalin as a novel early urinary biomarker for ischemic renal injury
    Jaya Mishra
    Nephrology and Hypertension, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    J Am Soc Nephrol 14:2534-43. 2003
  5. ncbi Oxidant stress evoked by pacemaking in dopaminergic neurons is attenuated by DJ-1
    Jaime N Guzman
    Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Nature 468:696-700. 2010
  6. ncbi Molecular characterization and pattern of tissue expression of the gene for neutrophil gelatinase-associated lipocalin from humans
    J B Cowland
    Granulocyte Research Laboratory, Finsen Center, Department of Hematology, Rigshospitalet, Copenhagen University Hospital, Denmark
    Genomics 45:17-23. 1997
  7. pmc The Parkinson's disease protein DJ-1 is neuroprotective due to cysteine-sulfinic acid-driven mitochondrial localization
    Rosa M Canet-Aviles
    Laboratory of Neurogenetics, National Institute on Aging, 9000 Rockville Pike, Bethesda, MD 20892 1589, USA
    Proc Natl Acad Sci U S A 101:9103-8. 2004
  8. ncbi Isolation and primary structure of NGAL, a novel protein associated with human neutrophil gelatinase
    L Kjeldsen
    Departments of Hematology, University Hospital, Rigshospitalet, Copenhagen, Denmark
    J Biol Chem 268:10425-32. 1993
  9. pmc Lipocalin 2-deficient mice exhibit increased sensitivity to Escherichia coli infection but not to ischemia-reperfusion injury
    Thorsten Berger
    The Campbell Family Institute for Breast Cancer Research and the Ontario Cancer Institute, University Health Network, Toronto, ON, Canada M5G 2C1
    Proc Natl Acad Sci U S A 103:1834-9. 2006
  10. ncbi The neutrophil lipocalin NGAL is a bacteriostatic agent that interferes with siderophore-mediated iron acquisition
    David H Goetz
    Molecular and Cellular Biology Program, Fred Hutchinson Cancer Research Center, Box 357275, University of Washington, Seattle, WA 98105, USA
    Mol Cell 10:1033-43. 2002

Detail Information

Publications295 found, 100 shown here

  1. ncbi Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism
    Vincenzo Bonifati
    Genetic Epidemiologic Unit, Department of Clinical Genetics, Department of Epidemiology and Biostatistics, Erasmus Medical Center Rotterdam, Post Office Box 1738, 3000 DR Rotterdam, Netherlands
    Science 299:256-9. 2003
    ..Elucidating the physiological role of DJ-1 protein may promote understanding of the mechanisms of brain neuronal maintenance and pathogenesis of Parkinson's disease...
  2. ncbi Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron
    Trude H Flo
    Institute for Systems Biology, Seattle, Washington 98103, USA
    Nature 432:917-21. 2004
    ..Our finding represents a new component of the innate immune system and the acute phase response to infection...
  3. ncbi Neutrophil gelatinase-associated lipocalin (NGAL) as a biomarker for acute renal injury after cardiac surgery
    Jaya Mishra
    Division of Nephrology and Hypertension, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229 3039, USA
    Lancet 365:1231-8. 2005
    ..We tested the hypothesis that neutrophil gelatinase-associated lipocalin (NGAL) is an early biomarker for ischaemic renal injury after cardiopulmonary bypass...
  4. ncbi Identification of neutrophil gelatinase-associated lipocalin as a novel early urinary biomarker for ischemic renal injury
    Jaya Mishra
    Nephrology and Hypertension, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    J Am Soc Nephrol 14:2534-43. 2003
    ..The results indicate that NGAL may represent an early, sensitive, noninvasive urinary biomarker for ischemic and nephrotoxic renal injury...
  5. ncbi Oxidant stress evoked by pacemaking in dopaminergic neurons is attenuated by DJ-1
    Jaime N Guzman
    Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Nature 468:696-700. 2010
    ..Because drugs approved for human use can antagonize calcium entry through L-type channels, these results point to a novel neuroprotective strategy for both idiopathic and familial forms of Parkinson's disease...
  6. ncbi Molecular characterization and pattern of tissue expression of the gene for neutrophil gelatinase-associated lipocalin from humans
    J B Cowland
    Granulocyte Research Laboratory, Finsen Center, Department of Hematology, Rigshospitalet, Copenhagen University Hospital, Denmark
    Genomics 45:17-23. 1997
    ..1, and the LPS-inducible factor NF-kappa B...
  7. pmc The Parkinson's disease protein DJ-1 is neuroprotective due to cysteine-sulfinic acid-driven mitochondrial localization
    Rosa M Canet-Aviles
    Laboratory of Neurogenetics, National Institute on Aging, 9000 Rockville Pike, Bethesda, MD 20892 1589, USA
    Proc Natl Acad Sci U S A 101:9103-8. 2004
    ..We suggest that DJ-1 protects against neuronal death, and that this is signaled by acidification of the key cysteine residue, C106...
  8. ncbi Isolation and primary structure of NGAL, a novel protein associated with human neutrophil gelatinase
    L Kjeldsen
    Departments of Hematology, University Hospital, Rigshospitalet, Copenhagen, Denmark
    J Biol Chem 268:10425-32. 1993
    ..It is thus a new member of the lipocalin family. The function of the 25-kDa protein, named neutrophil gelatinase-associated lipocalin (NGAL), remains to be determined...
  9. pmc Lipocalin 2-deficient mice exhibit increased sensitivity to Escherichia coli infection but not to ischemia-reperfusion injury
    Thorsten Berger
    The Campbell Family Institute for Breast Cancer Research and the Ontario Cancer Institute, University Health Network, Toronto, ON, Canada M5G 2C1
    Proc Natl Acad Sci U S A 103:1834-9. 2006
    ..We analyzed Lcn2-/- mice using a mouse model for severe renal failure and could not detect any significant differences compared with their WT littermates...
  10. ncbi The neutrophil lipocalin NGAL is a bacteriostatic agent that interferes with siderophore-mediated iron acquisition
    David H Goetz
    Molecular and Cellular Biology Program, Fred Hutchinson Cancer Research Center, Box 357275, University of Washington, Seattle, WA 98105, USA
    Mol Cell 10:1033-43. 2002
    ..We therefore propose that NGAL participates in the antibacterial iron depletion strategy of the innate immune system...
  11. pmc DJ-1, a cancer- and Parkinson's disease-associated protein, stabilizes the antioxidant transcriptional master regulator Nrf2
    Casey M Clements
    Department of Microbiology Immunology, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599 7295, USA
    Proc Natl Acad Sci U S A 103:15091-6. 2006
    ..Furthermore, this DJ-1/Nrf2 functional axis presents a therapeutic target in cancer treatment and justifies DJ-1 as a tumor biomarker...
  12. pmc Molecular mechanisms of invadopodium formation: the role of the N-WASP-Arp2/3 complex pathway and cofilin
    Hideki Yamaguchi
    Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Cell Biol 168:441-52. 2005
    ..These results indicate that EGF receptor signaling regulates invadopodium formation through the N-WASP-Arp2/3 pathway and cofilin is necessary for the stabilization and maturation of invadopodia...
  13. ncbi The high molecular weight urinary matrix metalloproteinase (MMP) activity is a complex of gelatinase B/MMP-9 and neutrophil gelatinase-associated lipocalin (NGAL). Modulation of MMP-9 activity by NGAL
    L Yan
    Department of Surgery, Children s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 276:37258-65. 2001
    ..In summary, this study identifies the 125-kDa urinary gelatinase as being a complex of MMP-9 and NGAL and provides evidence that NGAL modulates MMP-9 activity by protecting it from degradation...
  14. ncbi Loss of the Parkinson's disease-linked gene DJ-1 perturbs mitochondrial dynamics
    I Irrcher
    Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Canada
    Hum Mol Genet 19:3734-46. 2010
    ..Our findings define a mechanism by which the DJ-1-dependent mitochondrial defects contribute to the increased sensitivity to oxidative stress-induced cell death that has been previously reported...
  15. ncbi Lipocalin-2 is an inflammatory marker closely associated with obesity, insulin resistance, and hyperglycemia in humans
    Yu Wang
    Genome Research Center and Department of Biochemistry, University of Hong Kong, Hong Kong, China
    Clin Chem 53:34-41. 2007
    ..Because lipocalin-2 is abundantly expressed in adipose tissue and liver, we investigated its relevance to obesity-related pathologies...
  16. ncbi A binding site for Gli proteins is essential for HNF-3beta floor plate enhancer activity in transgenics and can respond to Shh in vitro
    H Sasaki
    Laboratory of Developmental Biology, Osaka University, Suita, Japan
    Development 124:1313-22. 1997
    ..These results also support the idea that Gli/Ci are evolutionary conserved transcription factors in the Hedgehog signalling pathway...
  17. ncbi A cell-surface receptor for lipocalin 24p3 selectively mediates apoptosis and iron uptake
    Laxminarayana R Devireddy
    Howard Hughes Medical Institute, Programs in Gene Function and Expression and Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Cell 123:1293-305. 2005
    ..Our results reveal an unanticipated role for intracellular iron regulation in an apoptotic pathway relevant to BCR-ABL-induced myeloproliferative disease and its treatment...
  18. pmc Endocytic delivery of lipocalin-siderophore-iron complex rescues the kidney from ischemia-reperfusion injury
    Kiyoshi Mori
    Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    J Clin Invest 115:610-21. 2005
    ..We reveal what we believe to be a novel pathway of iron traffic that is activated in human and mouse renal diseases, and it provides a unique method for their treatment...
  19. pmc Cyclin E amplification/overexpression is a mechanism of trastuzumab resistance in HER2+ breast cancer patients
    Maurizio Scaltriti
    Departments of Medical Oncology and Molecular Pathology, Vall d Hebron Institute of Oncology, 08035 Barcelona, Spain
    Proc Natl Acad Sci U S A 108:3761-6. 2011
    ....
  20. pmc DJ-1 knock-down impairs astrocyte mitochondrial function
    N J Larsen
    Department of Neurology, Pittsburgh Institute for Neurodegenerative Diseases, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Neuroscience 196:251-64. 2011
    ....
  21. pmc Amplification of LAPTM4B and YWHAZ contributes to chemotherapy resistance and recurrence of breast cancer
    Yang Li
    Department of Cancer Biology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA
    Nat Med 16:214-8. 2010
    ..Overexpression of these two genes may predict anthracycline resistance and influence selection of chemotherapy...
  22. pmc DJ-1 acts in parallel to the PINK1/parkin pathway to control mitochondrial function and autophagy
    Kelly Jean Thomas
    Laboratory of Neurogenetics, National Institute on Aging, Flow Cytometry Core Facility, National Institutes of Neurological Diseases and Stroke, National Institutes of Health, Bethesda, MD 20982 3707, USA
    Hum Mol Genet 20:40-50. 2011
    ..None of the three proteins complex together using size exclusion chromatography. These data suggest that DJ-1 works in parallel to the PINK1/parkin pathway to maintain mitochondrial function in the presence of an oxidative environment...
  23. pmc Parkinson's disease-associated DJ-1 mutations impair mitochondrial dynamics and cause mitochondrial dysfunction
    Xinglong Wang
    Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA
    J Neurochem 121:830-9. 2012
    ..Taken together, these studies suggest that DJ-1 is involved in the regulation of mitochondrial dynamics through modulation of DLP1 expression and PD-associated DJ-1 mutations may cause PD by impairing mitochondrial dynamics and function...
  24. pmc Oxidative damage of DJ-1 is linked to sporadic Parkinson and Alzheimer diseases
    Joungil Choi
    Department of Pharmacology, Center for Neurodegenerative Disease, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 281:10816-24. 2006
    ..Our study provides new insights into the oxidative modifications of DJ-1 and indicates association of oxidative damage to DJ-1 with sporadic PD and AD...
  25. pmc DJ-1 gene deletion reveals that DJ-1 is an atypical peroxiredoxin-like peroxidase
    Eva Andres-Mateos
    Institute for Cell Engineering, Johns Hopkins University School of Medicine, 733 North Broadway, Suite 731, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 104:14807-12. 2007
    ..Taken together these data indicate that the DJ-1 KO mice have a deficit in scavenging mitochondrial H(2)O(2) due to the physiological function of DJ-1 as an atypical peroxiredoxin-like peroxidase...
  26. ncbi Hedgehog signaling pathway is a new therapeutic target for patients with breast cancer
    Makoto Kubo
    Department of Cancer Therapy and Research, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Cancer Res 64:6071-4. 2004
    ..These data indicate that the Hh pathway is a new candidate for therapeutic target of breast cancer...
  27. pmc Hypersensitivity of DJ-1-deficient mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrindine (MPTP) and oxidative stress
    Raymond H Kim
    Campbell Family Institute for Breast Cancer Research, Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada M5G 2C1
    Proc Natl Acad Sci U S A 102:5215-20. 2005
    ..Thus, DJ-1 protects against neuronal oxidative stress, and loss of DJ-1 may lead to Parkinson's disease by conferring hypersensitivity to dopaminergic insults...
  28. pmc The MYCN oncogene is a direct target of miR-34a
    J S Wei
    Oncogenomics Section, Pediatric Oncology Branch, Advanced Technology Center, National Cancer Institute, Gaithersburg, MD 20892, USA
    Oncogene 27:5204-13. 2008
    ..This study demonstrates one important regulatory role of miR-34a in cell growth and MYCN suppression in neuroblastoma...
  29. pmc High-throughput stem-loop RT-qPCR miRNA expression profiling using minute amounts of input RNA
    Pieter Mestdagh
    Center for Medical Genetics, Ghent University Hospital, Ghent, Belgium
    Nucleic Acids Res 36:e143. 2008
    ..The high specificity of RT-qPCR together with a superior sensitivity makes this approach the method of choice for high-throughput miRNA expression profiling...
  30. pmc DJ-1 is a redox-dependent molecular chaperone that inhibits alpha-synuclein aggregate formation
    Shoshana Shendelman
    Department of Pathology, Center for Neurobiology and Behavior, and Taub Institute, Columbia University, College of Physicians and Surgeons, New York, New York, USA
    PLoS Biol 2:e362. 2004
    ..We further demonstrate that DJ-1 chaperone activity in vivo extends to alpha-synuclein, a protein implicated in PD pathogenesis...
  31. pmc Distinct transcriptional MYCN/c-MYC activities are associated with spontaneous regression or malignant progression in neuroblastomas
    Frank Westermann
    Department of Tumor Genetics, German Cancer Research Center, Im Neuenheimer Feld 280, Heidelberg, Germany
    Genome Biol 9:R150. 2008
    ..In this study, we asked whether distinct transcriptional MYCN or c-MYC activities are associated with specific neuroblastoma phenotypes...
  32. ncbi MYC in oncogenesis and as a target for cancer therapies
    Ami Albihn
    Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden
    Adv Cancer Res 107:163-224. 2010
    ..If successful a MYC-targeting therapy has the potential for tailored treatment of a large number of different tumors...
  33. ncbi ROS-dependent regulation of Parkin and DJ-1 localization during oxidative stress in neurons
    Alvin P Joselin
    Department of Cellular and Molecular Medicine, University of Ottawa, 451 Smyth Road, Ottawa, Ontario, Canada
    Hum Mol Genet 21:4888-903. 2012
    ..These results not only highlight the presence of a Parkin/Pink1-mediated pathway of mitochondrial quality control (MQC) in neurons, they also delineate a complex reciprocal relationship between DJ-1 and the Pink1/Parkin pathway of MQC...
  34. pmc Decline in NRF2-regulated antioxidants in chronic obstructive pulmonary disease lungs due to loss of its positive regulator, DJ-1
    Deepti Malhotra
    Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Room E7624, 615 North Wolfe St, Baltimore, MD 21205, USA
    Am J Respir Crit Care Med 178:592-604. 2008
    ..NRF2, a redox-sensitive transcription factor, dissociates from its inhibitor, KEAP1, to induce antioxidant expression that inhibits oxidative stress...
  35. pmc Functional MYCN signature predicts outcome of neuroblastoma irrespective of MYCN amplification
    Linda J Valentijn
    Department of Oncogenomics, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Proc Natl Acad Sci U S A 109:19190-5. 2012
    ..The functional MYCN-157 signature recognizes classical neuroblastoma with MYCN amplification, as well as a newly identified group marked by MYCN protein stabilization...
  36. ncbi The endocytic receptor megalin binds the iron transporting neutrophil-gelatinase-associated lipocalin with high affinity and mediates its cellular uptake
    Vibeke Hvidberg
    Institute of Medical Biochemistry, University of Aarhus, Denmark
    FEBS Lett 579:773-7. 2005
    ..Furthermore, a rat yolk sac cell line known to express high levels of megalin, endocytosed NGAL by a mechanism completely blocked by an antibody against megalin...
  37. pmc Integrated genome-wide DNA copy number and expression analysis identifies distinct mechanisms of primary chemoresistance in ovarian carcinomas
    Dariush Etemadmoghadam
    Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia
    Clin Cancer Res 15:1417-27. 2009
    ..We analyzed somatic DNA copy number variation and gene expression data to identify key mechanisms associated with primary resistance in advanced-stage serous cancers...
  38. pmc DJ-1 regulation of mitochondrial function and autophagy through oxidative stress
    Melissa K McCoy
    Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA
    Autophagy 7:531-2. 2011
    ....
  39. ncbi Induction of reactive oxygen species by bisphenol A and abrogation of bisphenol A-induced cell injury by DJ-1
    Hiromasa Ooe
    Graduate School of Pharmaceutical Sciences, Graduate School of Agriculture, Hokkaido University, Sapporo 060 0812, Japan
    Toxicol Sci 88:114-26. 2005
    ..DJ-1 was found to maintain the complex I activity against BPA-induced oxidative stress after the localization in mitochondria. The results showed that DJ-1 plays a role in the prevention of mitochondrial injury-induced cell death...
  40. pmc DJ-1 is critical for mitochondrial function and rescues PINK1 loss of function
    Ling Yang Hao
    Department of Biology, Howard Hughes Medical Institute, University of Pennsylvania, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 107:9747-52. 2010
    ..These findings link DJ-1, pink1, and parkin to mitochondrial integrity and provide the foundation for therapeutics that link bioenergetics and parkinsonism...
  41. pmc KIF14 and citron kinase act together to promote efficient cytokinesis
    Ulrike Gruneberg
    Department of Cell Biology, Max Planck Institute of Biochemistry, 82152 Martinsried, Germany
    J Cell Biol 172:363-72. 2006
    ..Atzori, E. Turco, R. Triolo, G.P. Dotto, et al. 2000. Neuron. 28:115-127), we find a general requirement for citron kinase in human cell division. Together, these findings identify a novel pathway required for efficient cytokinesis...
  42. ncbi DJ-1 decreases Bax expression through repressing p53 transcriptional activity
    Jun Fan
    Laboratory of Molecular Neuropathology, Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230027, China
    J Biol Chem 283:4022-30. 2008
    ..Our data provide evidence that the protective effects of DJ-1 on apoptosis are associated with its ability of decreasing Bax level through inhibiting p53 transcriptional activity...
  43. pmc Mitochondrial localization of DJ-1 leads to enhanced neuroprotection
    Eunsung Junn
    Center for Neurodegenerative and Neuroimmunologic Diseases, Department of Neurology, UMDNJ Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    J Neurosci Res 87:123-9. 2009
    ..These findings further highlight the multifaceted functions of DJ-1 as a cytoprotector in different cellular compartments...
  44. ncbi Mitochondrial localization of the Parkinson's disease related protein DJ-1: implications for pathogenesis
    Li Zhang
    Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Hum Mol Genet 14:2063-73. 2005
    ..Our findings of DJ-1's mitochondrial localization may have important implications for understanding the pathogenesis of PD...
  45. ncbi Altered neural cell fates and medulloblastoma in mouse patched mutants
    L V Goodrich
    Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305 5427, USA
    Science 277:1109-13. 1997
    ..Mice heterozygous for the ptc mutation were larger than normal, and a subset of them developed hindlimb defects or cerebellar medulloblastomas, abnormalities also seen in BCNS patients...
  46. pmc Reduced basal autophagy and impaired mitochondrial dynamics due to loss of Parkinson's disease-associated protein DJ-1
    Guido Krebiehl
    Center of Neurology and Hertie Institute for Clinical Brain Research, University of Tubingen, Tubingen, Germany
    PLoS ONE 5:e9367. 2010
    ..Although a critical role of DJ-1 in oxidative stress response and mitochondrial function has been recognized, the effects on mitochondrial dynamics and downstream consequences remain to be determined...
  47. ncbi MYCN/c-MYC-induced microRNAs repress coding gene networks associated with poor outcome in MYCN/c-MYC-activated tumors
    P Mestdagh
    Center for Medical Genetics, Ghent University Hospital, Ghent, Belgium
    Oncogene 29:1394-404. 2010
    ..Our results uncover a widespread correlation between miRNA activation and c-MYC/MYCN-mediated coding gene expression modulation and further substantiate the overlapping functions of c-MYC and MYCN in the process of tumorigenesis...
  48. pmc MicroRNA-184 inhibits neuroblastoma cell survival through targeting the serine/threonine kinase AKT2
    Niamh H Foley
    Department of Cancer Genetics, Royal College of Surgeons in Ireland, York House, York Street, Dublin 2, Ireland
    Mol Cancer 9:83. 2010
    ..The purpose of this study was to elucidate the molecular mechanism by which miR-184 conveys pro-apoptotic effects...
  49. ncbi Nck in a complex containing the catalytic subunit of protein phosphatase 1 regulates eukaryotic initiation factor 2alpha signaling and cell survival to endoplasmic reticulum stress
    Mathieu Latreille
    Polypeptide Hormone Laboratory, Department of Medicine, McGill University, Montreal, Quebec H3A 2B2, Canada
    J Biol Chem 281:26633-44. 2006
    ..In this manner, Nck modulates translation and eIF2alpha signaling in response to ER stress...
  50. pmc Bmi-1 is essential for the tumorigenicity of neuroblastoma cells
    Hongjuan Cui
    Department of Biochemistry and Cancer Biology, Medical University of Ohio, 3035 Arlington Ave, Toledo, OH 43614, USA
    Am J Pathol 170:1370-8. 2007
    ..These findings suggest a crucial role for Bmi-1 in neuroblastoma pathogenesis and provide insights into the molecular basis of neuroblastoma heterogeneity...
  51. ncbi Activation of Pak by membrane localization mediated by an SH3 domain from the adaptor protein Nck
    W Lu
    Howard Hughes Medical Institute, Children s Hospital, Boston, Massachusetts 02115, USA
    Curr Biol 7:85-94. 1997
    ..The Pak family of serine/threonine kinases are known to be activated by binding to the GTP-bound form of Cdc42 or Rac1, which are small GTPases of the Rho family that are involved in regulating the organization of the actin cytoskeleton...
  52. pmc Parkin, PINK1, and DJ-1 form a ubiquitin E3 ligase complex promoting unfolded protein degradation
    Hui Xiong
    Burnham Institute for Medical Research, 10901 N Torrey Pines Road, La Jolla, CA 92037, USA
    J Clin Invest 119:650-60. 2009
    ....
  53. ncbi Nigrostriatal dopaminergic deficits and hypokinesia caused by inactivation of the familial Parkinsonism-linked gene DJ-1
    Matthew S Goldberg
    Center for Neurologic Diseases, Brigham and Women s Hospital, Program in Neuroscience, Harvard Medical School, Boston, Massachusetts 02115, USA
    Neuron 45:489-96. 2005
    ..Furthermore, DJ-1(-/-) mice displayed hypoactivity in the open field. Collectively, our findings suggest an essential role for DJ-1 in dopaminergic physiology and D2 receptor-mediated functions...
  54. pmc A bacterial cytotoxin identifies the RhoA exchange factor Net1 as a key effector in the response to DNA damage
    Lina Guerra
    Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden
    PLoS ONE 3:e2254. 2008
    ..The signalling intermediates that regulate RhoA activation and promote cell survival are unknown...
  55. pmc The role of cysteine oxidation in DJ-1 function and dysfunction
    Mark A Wilson
    Department of Biochemistry, Redox Biology Center, The University of Nebraska Lincoln, 68588 0664, USA
    Antioxid Redox Signal 15:111-22. 2011
    ....
  56. ncbi An iron delivery pathway mediated by a lipocalin
    Jun Yang
    College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
    Mol Cell 10:1045-56. 2002
    ..These studies identify an iron delivery pathway active in development and cell physiology...
  57. ncbi DJ-1 promotes invasion and metastasis of pancreatic cancer cells by activating SRC/ERK/uPA
    Xiangyi He
    Department of Gastroenterology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
    Carcinogenesis 33:555-62. 2012
    ..These data represent the first identification of an important function of DJ-1, which is to regulate the invasion and metastasis properties of PDAC through the ERK/uPA cascade...
  58. ncbi The Yin and Yang functions of the Myc oncoprotein in cancer development and as targets for therapy
    Lars Gunnar Larsson
    Department of Microbiology, Tumor and Cell Biology MTC, Karolinska Institutet, Box 280, 171 77 Stockholm, Sweden
    Exp Cell Res 316:1429-37. 2010
    ....
  59. ncbi Identification of common transcriptional regulatory elements in interleukin-17 target genes
    Fang Shen
    Department of Oral Biology, School of Dental Medicine, University at Buffalo, State University of New York, Buffalo, New York 14214, USA
    J Biol Chem 281:24138-48. 2006
    ..Analysis of IL-17 target gene regulation is key for understanding this important host-defense molecule and also contributes to an understanding of upstream signaling mechanisms used by IL-17, either alone or in concert with TNFalpha...
  60. ncbi DJ-1 up-regulates glutathione synthesis during oxidative stress and inhibits A53T alpha-synuclein toxicity
    Wenbo Zhou
    Division of Clinical Pharmacology and Toxicology, Department of Medicine, University Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Biol Chem 280:43150-8. 2005
    ..We conclude that DJ-1 has multiple specific mechanisms for protecting dopamine neurons from cell death...
  61. pmc Iron traffics in circulation bound to a siderocalin (Ngal)-catechol complex
    Guanhu Bao
    College of Physicians and Surgeons of Columbia University, New York, New York, USA
    Nat Chem Biol 6:602-9. 2010
    ..These results identify an endogenous siderophore, which may link the disparate roles of Scn-Ngal in different diseases...
  62. ncbi Inhibition of lipocalin 2 impairs breast tumorigenesis and metastasis
    Xiaohong Leng
    Department of Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77054, USA
    Cancer Res 69:8579-84. 2009
    ..Our results suggest that inhibition of LCN2 function by an inhibitory monoclonal antibody has potential for breast cancer therapy, particularly by interfering with metastasis in aggressive types of breast cancer...
  63. ncbi Gli proteins encode context-dependent positive and negative functions: implications for development and disease
    A Ruiz i Altaba
    The Skirball Institute, Developmental Genetics Program and Department of Cell Biology, NYU School of Medicine, New York, NY 10016, USA
    Development 126:3205-16. 1999
    ..Interpretation of Hh signals by Gli proteins therefore appears to involve a fine balance of divergent functions within each and among different Gli proteins, the misregulation of which has profound biological consequences...
  64. pmc ODC1 is a critical determinant of MYCN oncogenesis and a therapeutic target in neuroblastoma
    Michael D Hogarty
    Division of Oncology, The Children s Hospital of Philadelphia, Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 4318, USA
    Cancer Res 68:9735-45. 2008
    ....
  65. ncbi All mouse ventral spinal cord patterning by hedgehog is Gli dependent and involves an activator function of Gli3
    C Brian Bai
    Howard Hughes Medical Institute and Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, and Department of Cell Biology, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
    Dev Cell 6:103-15. 2004
    ..Therefore, in the spinal cord all Hh signaling is Gli dependent. Furthermore, a combination of Gli2 and Gli3 is required to regulate motor neuron development and spatial patterning of ventral spinal cord progenitors...
  66. ncbi Induction of apoptosis by a secreted lipocalin that is transcriptionally regulated by IL-3 deprivation
    L R Devireddy
    Howard Hughes Medical Institute, Program in Gene Function and Expression and Program in Molecular Medicine, University of Massachusetts Medical School, 373 Plantation Street, Worcester, MA 01605, USA
    Science 293:829-34. 2001
    ..We conclude that IL-3 deprivation activates 24p3 transcription, leading to synthesis and secretion of 24p3, which induces apoptosis through an autocrine pathway...
  67. ncbi Reduced anti-oxidative stress activities of DJ-1 mutants found in Parkinson's disease patients
    Kazuko Takahashi-Niki
    CREST, Japan Science and Technology Corporation, 4 1 8 Honcho, Kawaguchi, Saitama 332 0012, Japan
    Biochem Biophys Res Commun 320:389-97. 2004
    ..These cell lines also showed that all of the mutants had reduced activities to eliminate exogenously added H2O2 and that these activities, except for that of D149A, were parallel to those preventing H2O2-induced cell death...
  68. pmc Sensitivity to oxidative stress in DJ-1-deficient dopamine neurons: an ES- derived cell model of primary Parkinsonism
    Cecile Martinat
    Department of Pathology, Center for Neurobiology and Behavior, and Taub Institute, Columbia University, New York, New York, USA
    PLoS Biol 2:e327. 2004
    ..These data are consistent with a protective role for DJ-1, and demonstrate the utility of genetically modified embryonic stem cell-derived neurons as cellular models of neuronal disorders...
  69. pmc WISP genes are members of the connective tissue growth factor family that are up-regulated in wnt-1-transformed cells and aberrantly expressed in human colon tumors
    D Pennica
    Department of Molecular Oncology, Genentech Inc, 1 DNA Way, South San Francisco, CA 94080, USA
    Proc Natl Acad Sci U S A 95:14717-22. 1998
    ..These results suggest that the WISP genes may be downstream of Wnt-1 signaling and that aberrant levels of WISP expression in colon cancer may play a role in colon tumorigenesis...
  70. ncbi DJ-1 protects against dopamine toxicity
    Nirit Lev
    Department of Neurology, Felsenstein Medical Research Centre, Rabin Medical Centre, Tel Aviv University, Petah Tikva, Israel
    J Neural Transm 116:151-60. 2009
    ..This mechanism elucidates how mutations in DJ-1 prompt PD and imply that modulation of DJ-1 may serve as a novel neuroprotective modality...
  71. pmc Lipocalin 2 is essential for chronic kidney disease progression in mice and humans
    Amandine Viau
    INSERM U845, Centre de Recherche Croissance et Signalisation, Universite Paris Descartes, Hopital Necker Enfants Malades, Paris, France
    J Clin Invest 120:4065-76. 2010
    ..Together our results uncover what we believe to be a novel function for Lcn2 and a critical pathway leading to progressive renal failure and cystogenesis...
  72. pmc Formation of a stabilized cysteine sulfinic acid is critical for the mitochondrial function of the parkinsonism protein DJ-1
    Jeff Blackinton
    Cell Biology and Gene Expression Unit, Laboratory of Neurogenetics, NIA, National Institutes of Health, Bethesda, Maryland 20892 3707, USA
    J Biol Chem 284:6476-85. 2009
    ..We therefore conclude that formation of Cys106-sulfinic acid is a key modification that regulates the protective function of DJ-1...
  73. ncbi DJ-1 and prevention of oxidative stress in Parkinson's disease and other age-related disorders
    Philipp J Kahle
    Department of Neurodegeneration, Hertie Institute for Clinical Brain Research, University Clinics Tübingen, 72076 Tubingen, Germany
    Free Radic Biol Med 47:1354-61. 2009
    ..Augmenting DJ-1 activity might provide novel approaches to treating chronic neurodegenerative illnesses such as Parkinson's disease and acute damage such as stroke...
  74. ncbi DJ-1, a novel oncogene which transforms mouse NIH3T3 cells in cooperation with ras
    D Nagakubo
    Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan
    Biochem Biophys Res Commun 231:509-13. 1997
    ..Moreover, DJ-1 translocated from cytoplasm to nuclei in the S phase of the cell cycle. DJ-1 is thus suggested to be a novel mitogen-dependent oncogene product involved in a Ras-related signal transduction pathway...
  75. ncbi Daxx and histone deacetylase II associate with chromatin through an interaction with core histones and the chromatin-associated protein Dek
    Andrew D Hollenbach
    Department of Genetics, St Jude Children s Research Hospital, 332 North Lauderdale, Memphis, TN 38105, USA
    J Cell Sci 115:3319-30. 2002
    ..A working model for the repressive action of hDaxx through its association with chromatin related proteins is presented...
  76. ncbi The rate of N-WASP exchange limits the extent of ARP2/3-complex-dependent actin-based motility
    Ina Weisswange
    Cell Motility Laboratory, Cancer Research UK, London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    Nature 458:87-91. 2009
    ..We suggest that the exchange rate of N-WASP controls the rate of ARP2/3-complex-dependent actin-based motility by regulating the extent of actin polymerization by antagonizing filament capping...
  77. ncbi E2F proteins regulate MYCN expression in neuroblastomas
    Verena Strieder
    Institute of Molecular Biology and Tumor Research IMT, Emil Mannkopff Strasse 2, 35033 Marburg, Germany
    J Biol Chem 278:2983-9. 2003
    ..These data suggest that E2F transcription factors are critical for both the full activation and the repression of MYCN in neuroblastomas...
  78. ncbi The oxidation state of DJ-1 regulates its chaperone activity toward alpha-synuclein
    Wenbo Zhou
    Department of Chemistry and Biochemistry, University of California, Santa Cruz, CA 95064, USA
    J Mol Biol 356:1036-48. 2006
    ....
  79. pmc Interaction of DJ-1 with Daxx inhibits apoptosis signal-regulating kinase 1 activity and cell death
    Eunsung Junn
    Center for Neurodegenerative and Neuroimmunologic Diseases, Department of Neurology, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
    Proc Natl Acad Sci U S A 102:9691-6. 2005
    ..These findings suggest that the regulated sequestration of Daxx in the nucleus and keeping apoptosis signal-regulating kinase 1 activation in check is a critical mechanism by which DJ-1 exerts its cytoprotective function...
  80. pmc DJ-1 expression modulates astrocyte-mediated protection against neuronal oxidative stress
    Steven J Mullett
    Department of Neurology and Pittsburgh Institute for Neurodegenerative Diseases, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    J Mol Neurosci 49:507-11. 2013
    ..This is the first demonstration that the manipulation of a PD-causing gene in astrocytes affects their ability to protect neurons against oxidative stress...
  81. pmc DJ-1 deficiency in astrocytes selectively enhances mitochondrial Complex I inhibitor-induced neurotoxicity
    Steven J Mullett
    Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15260, USA
    J Neurochem 117:375-87. 2011
    ..Further investigations into our model suggested that astrocytic GSH and heme oxygenase-1 antioxidant systems are not central to the neuroprotective mechanism...
  82. pmc The 1.1-A resolution crystal structure of DJ-1, the protein mutated in autosomal recessive early onset Parkinson's disease
    Mark A Wilson
    Department of Biochemistry and Chemistry and Rosenstiel Basic Medical Sciences Research Center, Brandeis University, 415 South Street, MS 029, Waltham, MA 02454 9110, USA
    Proc Natl Acad Sci U S A 100:9256-61. 2003
    ..Taken together, the crystal structure of human DJ-1 plus other observations suggest the possible involvement of this protein in the cellular oxidative stress response and a general etiology of neurodegenerative diseases...
  83. ncbi Pathological properties of the Parkinson's disease-associated protein DJ-1 in alpha-synucleinopathies and tauopathies: relevance for multiple system atrophy and Pick's disease
    Manuela Neumann
    Institute of Neuropathology, Ludwig Maximilians University of Munich, Munich, Germany
    Acta Neuropathol 107:489-96. 2004
    ..Our results suggest that DJ-1 is up-regulated in reactive astrocytes as well as in neuronal and glial cells with specific alpha-synucleinopathy and tauopathy...
  84. ncbi DJ-1 modulates the expression of Cu/Zn-superoxide dismutase-1 through the Erk1/2-Elk1 pathway in neuroprotection
    Zhiquan Wang
    Laboratory of Neurodegenerative Diseases, Institute of Health Science, Shanghai Institutes for Biological Sciences, Chinese Academy of Science and Shanghai Jiao Tong University School of Medicine, Shanghai, China
    Ann Neurol 70:591-9. 2011
    ..However, the mechanisms underlying dopaminergic neuron loss related to DJ-1 mutation remain undefined. Therefore, it is important to find the new mechanisms underlying the antioxidative functions of DJ-1...
  85. pmc Post-transcriptional gene regulation by HuR promotes a more tumorigenic phenotype
    K Mazan-Mamczarz
    Marlene and Stewart Greenebaum Cancer Center, University of Maryland, Baltimore, MD 21201, USA
    Oncogene 27:6151-63. 2008
    ....
  86. pmc Melanoma proliferation and chemoresistance controlled by the DEK oncogene
    Michael S Khodadoust
    Program in Immunology, Department of Dermatology, Michigan Center for Translational Pathology, and Howard Hughes Medical Institute, University of Michigan Medical Center, Ann Arbor, Michigan 48109 5640, USA
    Cancer Res 69:6405-13. 2009
    ..These results provide support for DEK as a long sought-after oncogene mapping at chromosome 6, with novel functions in melanoma proliferation and chemoresistance...
  87. ncbi Nck adaptor proteins link nephrin to the actin cytoskeleton of kidney podocytes
    Nina Jones
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario M5G 1X5, Canada
    Nature 440:818-23. 2006
    ..Simple and widely expressed SH2/SH3 adaptor proteins can therefore direct the formation of a specialized cellular morphology in vivo...
  88. ncbi LAPTM4B-35 is a novel prognostic factor of hepatocellular carcinoma
    Hua Yang
    Department of Cell Biology, School of Basic Medical Sciences, Peking University, Beijing, China
    J Surg Oncol 101:363-9. 2010
    ..However, the potential clinical implications of LAPTM4B-35 in HCC are still unclear. This study is aimed to investigate the correlations between LAPTM4B-35 expression and prognosis in patients with HCC...
  89. pmc p53 is a direct transcriptional target of MYCN in neuroblastoma
    Lindi Chen
    Northern Institute for Cancer Research, Newcastle University, Department of Cellular Pathology, Royal Victoria Infirmary, Newcastle upon Tyne NE2 4H, United Kingdom
    Cancer Res 70:1377-88. 2010
    ..We concluded that MYCN transcriptionally upregulates p53 in neuroblastoma and uses p53 to mediate a key mechanism of apoptosis...
  90. ncbi The role of MYCN in the failure of MYCN amplified neuroblastoma cell lines to G1 arrest after DNA damage
    Emma Bell
    Northern Institute for Cancer Research, University of Newcastle upon Tyne, Newcastle upon Tyne, UK
    Cell Cycle 5:2639-47. 2006
    ..This study is the first to determine that MNA correlates with a failure to G1 arrest and attenuated p21(WAF1) induction; however MYCN expression alone is not causally responsible...
  91. ncbi Kinesin family member 14: an independent prognostic marker and potential therapeutic target for ovarian cancer
    Brigitte L Thériault
    Campbell Family Cancer Research Institute, Ontario Cancer Institute, University Health Network, Toronto, ON, Canada
    Int J Cancer 130:1844-54. 2012
    ..Dependence of OvCa cells on KIF14 for maintenance of in vitro colony formation suggests a role of KIF14 in promoting a tumorigenic phenotype, beyond its known role in proliferation...
  92. ncbi DJ-1 transcriptionally up-regulates the human tyrosine hydroxylase by inhibiting the sumoylation of pyrimidine tract-binding protein-associated splicing factor
    Nan Zhong
    Department of Neurology, Caritas St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02135, USA
    J Biol Chem 281:20940-8. 2006
    ..Therefore, our results suggest DJ-1 as a regulator of protein sumoylation and directly link the loss of DJ-1 expression and transcriptional dysfunction to impaired dopamine synthesis...
  93. pmc Parkinson disease protein DJ-1 converts from a zymogen to a protease by carboxyl-terminal cleavage
    Jue Chen
    Department of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322 3090, USA
    Hum Mol Genet 19:2395-408. 2010
    ..Our findings support a role for DJ-1 protease in cellular defense against oxidative stress and have important implications for understanding and treating PD...
  94. ncbi Familial Parkinson's disease-associated L166P mutation disrupts DJ-1 protein folding and function
    James A Olzmann
    Departments of Pharmacology, Biochemistry, and Neurology, Center for Neurodegenerative Disease, Emory University School of Medicine, Atlanta, Georgia 30322 3090, USA
    J Biol Chem 279:8506-15. 2004
    ..Together these findings provide insights into the molecular mechanism by which loss-of-function mutations in DJ-1 lead to Parkinson's disease...
  95. ncbi The 1,25(OH)2D3-regulated transcription factor MN1 stimulates vitamin D receptor-mediated transcription and inhibits osteoblastic cell proliferation
    Amelia L M Sutton
    Department of Pharmacology, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, Ohio 44106, USA
    Mol Endocrinol 19:2234-44. 2005
    ..Collectively, these data indicate that MN1 is a 1,25-(OH)2D3-induced VDR coactivator that also may have critical roles in modulating osteoblast proliferation...
  96. ncbi Phosphatidylinositol 4,5-biphosphate (PIP2)-induced vesicle movement depends on N-WASP and involves Nck, WIP, and Grb2
    Stefanie Benesch
    Department of Cell Biology, Gesellschaft fur Biotechnologische Forschung GBF, Mascheroder Weg 1, D 38124 Braunschweig, Germany
    J Biol Chem 277:37771-6. 2002
    ....
  97. ncbi MYCN sensitizes human neuroblastoma to apoptosis by HIPK2 activation through a DNA damage response
    Marialaura Petroni
    Department of Experimental Medicine, Sapienza University of Rome, Policlinico Umberto I, Viale Regina Elena, 324, 00161, Rome, Italy
    Mol Cancer Res 9:67-77. 2011
    ..Altogether, our data uncover a novel mechanism linking MYCN to apoptosis that can be triggered by the p53-reactivating compound Nutlin-3, supporting its use in the most difficult-to-treat subset of neuroblastoma...
  98. ncbi DJ-1 positively regulates the androgen receptor by impairing the binding of PIASx alpha to the receptor
    K Takahashi
    Core Research for Evolutional Science and Technology, Japan Science and Technology Corporation, 4 1 8 Honcho, Kawaguchi, Saitama 332 0012, Japan
    J Biol Chem 276:37556-63. 2001
    ..These results indicate that DJ-1 is a positive regulator of the androgen receptor...
  99. pmc Overexpression of the cellular DEK protein promotes epithelial transformation in vitro and in vivo
    Trisha M Wise-Draper
    Division of Hematology Oncology, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
    Cancer Res 69:1792-9. 2009
    ..Taken together, our data uncover oncogenic DEK activities as postulated from its frequent up-regulation in human malignancies, and suggest that the targeted suppression of DEK may become a strategic approach to the treatment of cancer...
  100. ncbi The Parkinson's disease-associated DJ-1 protein is a transcriptional co-activator that protects against neuronal apoptosis
    Jin Xu
    Department of Neurology, Caritas St Elizabeth s Center, Tufts University School of Medicine, Boston, MA 02135, USA
    Hum Mol Genet 14:1231-41. 2005
    ..Mutations that impair the transcriptional co-activator function of DJ-1 render dopaminergic neurons vulnerable to apoptosis and may contribute to the pathogenesis of PD...
  101. ncbi Prognostic significance of gene expression profiles of metastatic neuroblastomas lacking MYCN gene amplification
    Shahab Asgharzadeh
    Department of Pediatrics, Division of Hematology Oncology, Childrens Hospital Los Angeles and Saban Research Institute, University of Southern California, Los Angeles, CA, USA
    J Natl Cancer Inst 98:1193-203. 2006
    ..We examined whether molecular classification of metastatic neuroblastomas without MYCN gene amplification at diagnosis using gene expression profiling could improve the prediction of risk of disease progression...

Research Grants62

  1. FUNCTIONAL DISSECTION OF CBLS TRANSFORMING DOMAIN
    Hamid Band; Fiscal Year: 2002
    ..Analyses of ZAP70 and PDGFRa should also provide insights directly relevant to immune deficiencies, auto-immunity and cancer. ..
  2. Diagnosis, Prognosis and Treatment of hRgr associated Hematopoietic Malignancies
    Angel Pellicer; Fiscal Year: 2012
    ..A companion diagnostic is necessary for a therapeutic that specifically targets the oncogene product to be useful. ..
  3. MITOGENIC AND ONCOGENIC REGULATION OF ERK/RSK SIGNALING
    John Blenis; Fiscal Year: 2012
    ..Eventually, this knowledge will result in the rationale design of targeted therapies that will be both efficacious and less toxic to the patient. ..
  4. CELL TRANSFORMATION BY BOVINE PAPILLOMAVIRUS
    DANIEL C DIMAIO; Fiscal Year: 2013
    ..In addition, on the basis of these studies, we will continue to develop a novel protein engineering method to control biological processes, including infection by human immunodeficiency virus, an important co-factor in many cancers. ..
  5. C-FES PROTEIN-TYROSINE KINASE IN MYELOID DIFFERENTIATION
    Robert Glazer; Fiscal Year: 1993
    ..Cognizance of this regulatory process should aid in the design of differentiation- specific therapies for myeloid leukemias...
  6. DEXAMETHASONE/NGF REGULATE CASEIN KINASE IN PC12 CELLS
    Robert Van Buskirk; Fiscal Year: 1990
    ....
  7. EXPRESSION OF MATRIX METALLOPROTEINASE AND P53
    Yubo Sun; Fiscal Year: 2004
    ..My specific research interest is to study the role of tumor suppressor protein and proto-oncogene proteins in the regulation of gene expression of MMPs and TIMPs and in the regulation of proliferation and apoptosis ..
  8. REGULATION OF MITOSIS IN NORMAL AND TRANSFORMED CELLS
    Robert Schlegel; Fiscal Year: 1993
    ..DNA damage; and 5) determining whether chromosomal instability induced by chemical clastogens or ras oncogene proteins is caused, at least in part, by mitosis occurring before, or shortly after, the completion of DNA ..
  9. NCI CLINICAL INVESTIGATOR AWARD
    Kemp Cease; Fiscal Year: 1990
    ..It is hoped that such studies may eventually elucidate strategies for induction of antigen-specific T cell immunity to human malignancies...
  10. METABOLIC DETERMINANTS OF HEMATOPOIETIC CELL DEVELOPMENT
    Daniel Wright; Fiscal Year: 1999
    ..also determine whether guanylate depletion and repletion affect the turnover and supply of short-lived proto oncogene proteins (e.g., c-myb) that influence hematopoietic cell growth and development...
  11. GERMLINE PROLIFERATION AND MEIOSIS IN C ELEGANS
    Tim Schedl; Fiscal Year: 2000
    ..This work may also provide new information about the cellular mechanisms that underlie human germline cancers. ..
  12. Novel Inhibitors for the Treatment of Highly Drug-Resistant Chronic Myelogenous
    GERARD HOUSEY; Fiscal Year: 2009
    ..PUBLIC HEALTH RELEVANCE: Development of novel therapeutic agents for the treatment of drug-resistant chronic myelogenous leukemia and other forms of cancer. ..
  13. SHEAR STRESS ENHANCEMENT OF SMOOTH MUSCLE CELL MIGRATION
    John Shyy; Fiscal Year: 2003
    ....
  14. ACQUISITION OF NMR SPECTROMETER
    William Bachovchin; Fiscal Year: 1991
    ..The requested instrument is essential for the proposed work and the proposed work will greatly benefit all of the above ongoing PHS-sponsored projects...
  15. TUMOR HOST RELATIONSHIPS IN HUMAN LYMPHOMAS IN VIVO
    Roger Warnke; Fiscal Year: 1993
    ..Long-term goals are to devise a more reproducible, clinically predictive classification of lymphomas. Such an in vivo evaluation of tumor host relationships should provide valuable insights in lymphoma immunobiology...
  16. MECHANISM OF ACTION OF HERCEPTIN R IN BREAST CANCER
    Jenny Chang; Fiscal Year: 2002
    ....
  17. REGULATION OF A C JUN KINASE BY A NOVEL TUMOR PROMOTER
    ELIZABETH WATTENBERG; Fiscal Year: 2001
    ..These studies may reveal a biochemical mechanism for the transmission of palytoxin-induced signals, and may also suggest a role for JNK in carcinogenesis. ..
  18. Action of Interferon in Chronic Myelogenous Leukemia
    Leonidas Platanias; Fiscal Year: 2005
    ..Identifying such mechanisms will facilitate the development of novel therapeutic approaches to overcome IFNa-resistance and the design of new pharmacologic agents for the treatment of CML...
  19. GENERAL PRE-MRNA SPLICING FACTORS IN DROSOPHILA
    Donald Rio; Fiscal Year: 2001
    ..Because many human diseases, such as beta-thalassemia, results from defects in pre-mRNA splicing, it is likely that alternative splicing defects may lead to oncogenic transformation of certain somatic cell types. ..
  20. BREAST CANCER IMAGING ANTIBODY DERIVED SMALL MOLECULES
    Alan Stolpen; Fiscal Year: 1999
    ..AME receptor binding site. Any promising 4D5.AME radioligands developed during this R21 granting period will be used as preliminary data in support of a future R01 proposal. ..
  21. MOLECULAR GENETIC ANALYSIS OF YEAST CASEIN KINASE II
    CLAIBORNE GLOVER; Fiscal Year: 2000
    ..CKII phosphorylates a broad spectrum of endogenous substrates, including several nuclear oncogene proteins. The activity is elevated in rapidly dividing normal cells, in transformed cells in culture, and in solid ..
  22. STRUCTURE AND MECHANISM OF PROTEIN PRENYLTRANSFERASES
    LORENA BEESE; Fiscal Year: 2002
    ..The FTase-mediated farnesylation of Ras oncogene proteins is absolutely required for their oncogenic, cell transforming activity...
  23. FASEB CONFERENCE/LOW MOLECULAR WEIGHT GTP BIND PROTIENS
    Gary Bokoch; Fiscal Year: 1991
    ..No other conferences on this topic area are to be held in 1990 or 1991 in North America. The ras oncogene proteins are the best characterized members of the LMWG family and ras serves as a prototype for studies on the other ..
  24. HUMAN DBL ONCOGENE PRODUCT
    Shiv Srivastava; Fiscal Year: 1992
    ..Furthermore, the distribution and levels of db1 protein will be evaluated in human neoplasms...
  25. RAS ONCOGENE-RELATED PROTEINS AND SECRETION
    JAMES ROTHMAN; Fiscal Year: 1993
    ..Thus work is likely to be of significance for cell biology, and may also afford novel insights into the basis of malignant transformation...
  26. RAS ONCOGENE RELATED PROTEINS AND SECRETION
    JAMES ROTHMAN; Fiscal Year: 1999
    ..Thus work is likely to be of significance for cell biology, and may also afford novel insights into the basis of malignant transformation. ..
  27. NON-ACUTE RETROVIRUSES AND DETERMINANTS OF ONCOGENICITY
    Susan Ross; Fiscal Year: 2004
    ..Thus, our studies will lead to a better understanding of the multiple mechanisms used by oncogenic retrovirus to infect and ultimately cause cancer within their host. ..
  28. Molecular screens for pVHL-associated isopeptidase VDU1
    Michael Mattern; Fiscal Year: 2005
    ..An assay for the related and highly homologous isopeptidase VDU2 will be developed in Phase II and hits from the VDU1 assay screened with this assay as well. ..
  29. Bacterial vector vaccine: Her-2/neu expressing tumors
    Yvonne Paterson; Fiscal Year: 2005
    ..This work will demonstrate the utility of the L. monocytogenes-based vaccines, thus setting the stage for further development of a breast cancer therapeutic that can be used in humans. ..
  30. ROLE OF TAK1 IN RANKL SIGNALING PATHWAY
    Jun Ninomiya Tsuji; Fiscal Year: 2005
    ..These studies will advance the understanding of the molecular mechanisms underlying the osteoclastogenesis and may offer novel therapeutic targets for bone diseases caused by excessive osteoclastogenesis. ..
  31. The Role of Doa4 in Membrane Protein Trafficking
    Alexander Amerik; Fiscal Year: 2006
    ..3. Proteins necessary for suppression of the doa4 degradation defect by mutations of Vps factors will be identified by mutagenesis, using chemical and genetic approaches. ..
  32. STRUCTURAL STUDIES OF ERBB/HER RECEPTOR DIMERIZATION
    Mark Lemmon; Fiscal Year: 2001
    ..Using similar approaches, we also propose to crystallize the extracellular domain of erbB2, which forms ligand-induced hetero-oligomers with other erbB receptors. ..
  33. Structural basis for erbB receptor activation
    Kathryn Ferguson; Fiscal Year: 2005
    ..While neuregulin (NRG1-beta1) binds to both the ECD of erbB3 and erbB4, it induces dimerization only of the erbB4 ECD. We will extend our crystallographic analysis to these other complexes. ..
  34. MUTANT P53 GAIN OF FUNCTION IN TUMORIGENESIS
    Gerard Zambetti; Fiscal Year: 2007
    ..abstract_text> ..
  35. CELL TRANSFORMATION BY DBL LIKE ONCOPROTEINS
    Danny Manor; Fiscal Year: 1999
    ..Additionally, the results of these studies will potentially allow for developing specific intervention strategies for Dbl-induced malignancies. ..
  36. CHARACTERIZATION OF THE V-ERB B ONCOGENE PROTEIN OF AEV
    Martin Privalsky; Fiscal Year: 1992
    ....
  37. ONCOGENE-SPECIFIC IMMUNE RESPONSES IN BREAST CANCER
    David Carbone; Fiscal Year: 1999
    ..with somatic mutations in dominant and recessive oncogenes including the p53 gene, and often produce mutant oncogene proteins that are uniquely present in the patient's cancer but not in his/her normal cells...
  38. BIOCHEMICAL AND FUNCTIONAL PROPERTIES OF SV40 T ANTIGEN
    Robert Carroll; Fiscal Year: 1992
    ..The long term goal is to elucidate the mechanism of this effect on host gene expression. ..
  39. SIGNAL TRANSDUCTION BY CELLULAR PROTOONCOGENES
    James Feramisco; Fiscal Year: 1992
    ..been able to establish unique assays for the analysis of the function of the cellular ras protooncogene and oncogene proteins in proliferation and differentiation, and for the analysis of the biological and biochemical activity of the ..
  40. BIOMARKERS OF ENVIRONMENTAL TOBACCO SMOKE EXPOSURE
    Frederica Perera; Fiscal Year: 1992
    ..The outcome of this study may have significant implications for risk assessment theory and practice...
  41. Cell Transformation by Dbl-like onco-proteins
    Danny Manor; Fiscal Year: 2006
    ..abstract_text> ..
  42. SURFACE MEMBRANES OF NORMAL AND CANCER CELLS
    LEONARD WARREN; Fiscal Year: 1990
    ..2) comparison of glycopeptides of control and transformed cells. 3) the influence of environment and drugs on the carbohydrate component of IgG produced by hybridomas and the consequences of altered carbohydrate structure...
  43. CIRCULATING C-NEU PROTEIN IN BREAST CANCER PATIENTS
    Daniel Hayes; Fiscal Year: 1992
    ....
  44. IMMUNOLOGIC ASSAYS TO ACTIVATED RAS ONCOGENE PROTEINS
    Fred Reynolds; Fiscal Year: 1992
    ..The ability to identify and quantitate activated p21ras proteins in tumors and serum may greatly facilitate the specific diagnosis and prognostic evaluation of human cancer...
  45. TUMOR CELL BIOLOGY OF THE FMS ONCOGENE PROTEINS
    LARRY ROHRSCHNEIDER; Fiscal Year: 2005
    ..Overall, the results of these experiments will describe new signaling mechanisms that may be useful for understanding the normal and abnormal development of blood cells and their diseases. ..
  46. PGDF-Dependent Regulation of EAAC1
    Amanda Sheldon; Fiscal Year: 2006
    ..Aim Ill is to identify structural motifs of EAAC1 required for PDGF-dependent trafficking, using chimeras and mutant variants of EAAC1. [unreadable] [unreadable]..
  47. T(15;19) in Aggressive Pediatric Carcinoma
    Christopher French; Fiscal Year: 2006
    ..These studies will also reveal the range of primary sites from which t(15;19)+ carcinomas arise. ..
  48. Jak2 involvement in Bcr-Abl oncogenic transformation
    Ralph Arlinghaus; Fiscal Year: 2005
    ..g. use of DN SH2-Bbeta) in Bcr-Abl-induced oncogenic effects. These studies will provide important new information on mechanism of Bcr-Abl positive leukemia, and will provide new strategies for therapy of these leukemias. ..
  49. TARGET-GUIDED DEVELOPMENT OF SPECIFIC AKT INHIBITORS
    Peter Vogt; Fiscal Year: 2008
    ..4) Investigate the structure-activity relationship through in situ click chemistry and optimize inhibitors for potency, selectivity and cell-based activity ..
  50. Molecular Control of Shh-Gli Signaling in the Vertebrate CNS
    Michael P Matise; Fiscal Year: 2010
    ..abstract_text> ..
  51. MOLECULAR REGULATION OF SIGNALING BY IONIZING RADIATION
    Donald Kufe; Fiscal Year: 2002
    ....
  52. TAM Receptor Regulation of Innate Immunity
    GREG E LEMKE; Fiscal Year: 2011
    ..Together, these studies will provide basic insights into a new signaling system of critical importance to the regulation of immune responses and the development of autoimmunity. ..
  53. Glial-Neuron Interactions: Genetic Studies
    Greg Lemke; Fiscal Year: 2005
    ..Together, these studies will yield fundamental new insights into the transcriptional regulation of glial-neuron interactions in the developing central and peripheral nervous systems. ..
  54. Alpha-Synuclein Conditional Knock-in Mice as Novel Models of Parkinson's Disease
    Darren Moore; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  55. Combinatorial Chemistry and Cancer Target
    Peter Vogt; Fiscal Year: 2008
    ..The collaborating groups of this Program Project have become an integrated unit that incorporates a wide range of expertise and interests and applies them to the common goal, new anticancer compounds. ..
  56. Molecular regulation of neurogenesis and cell fate
    Michael Matise; Fiscal Year: 2007
    ..abstract_text> ..
  57. Regulation of Oxidative Stress Response by c-Abl and Arg
    Donald Kufe; Fiscal Year: 2007
    ..abstract_text> ..
  58. MOLECULAR MECHANISMS OF ARA-C THERAPY IN MAN
    Donald Kufe; Fiscal Year: 2005
    ..abstract_text> ..
  59. THE ONCOGENICITY OF WINGED HELIX PROTEINS
    Peter Vogt; Fiscal Year: 2003
    ..The nature of activating mutations, the interactions with the preinitiation complex, and the identity and function of target genes will reveal novel molecular targets for therapeutic intervention. ..
  60. Potent inhibitors of Anthrax Lethal Factor
    Peter Vogt; Fiscal Year: 2003
    ..Libraries will be targeted using the structural information available for LF, supplemented by information from point mutations of the substrate. Information from our previous synthesis of metalloprotease inhibitors will also be used. ..
  61. Controlling the Max Network
    Peter Vogt; Fiscal Year: 2008
    ..The proposed work on stabilizers in the Myc-Max network could open the door to a new way of influencing and directing cell growth. ..