neoplasm proteins

Summary

Summary: Proteins whose abnormal expression (gain or loss) are associated with the development, growth, or progression of NEOPLASMS. Some neoplasm proteins are tumor antigens (ANTIGENS, NEOPLASM), i.e. they induce an immune reaction to their tumor. Many neoplasm proteins have been characterized and are used as tumor markers (TUMOR MARKERS, BIOLOGICAL) when they are detectable in cells and body fluids as monitors for the presence or growth of tumors. Abnormal expression of ONCOGENE PROTEINS is involved in neoplastic transformation, whereas the loss of expression of TUMOR SUPPRESSOR PROTEINS is involved with the loss of growth control and progression of the neoplasm.

Top Publications

  1. pmc Patterns of somatic mutation in human cancer genomes
    Christopher Greenman
    Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK
    Nature 446:153-8. 2007
  2. ncbi Multidrug resistance in cancer: role of ATP-dependent transporters
    Michael M Gottesman
    Laboratory of Cell Biology and Cancer Therapeutics Branch, The Center for Cancer Research, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Rev Cancer 2:48-58. 2002
  3. ncbi Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts
    T Komori
    Department of Medicine III, Osaka University Medical School, Suita, Japan
    Cell 89:755-64. 1997
  4. ncbi The genomic landscapes of human breast and colorectal cancers
    Laura D Wood
    Ludwig Center for Cancer Genetics and Therapeutics and Howard Hughes Medical Institute at Johns Hopkins Kimmel Cancer Center, Baltimore, MD 21231, USA
    Science 318:1108-13. 2007
  5. ncbi A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1
    Y Miki
    Department of Medical Informatics, University of Utah Medical Center, Salt Lake City 84132
    Science 266:66-71. 1994
  6. ncbi Neuroblastoma: biological insights into a clinical enigma
    Garrett M Brodeur
    Division of Oncology, The Children s Hospital of Philadelphia and the University of Pennsylvania, Philadelphia, Pennsylvania 19104 4318, USA
    Nat Rev Cancer 3:203-16. 2003
  7. pmc STIM is a Ca2+ sensor essential for Ca2+-store-depletion-triggered Ca2+ influx
    Jen Liou
    Department of Molecular Pharmacology, Stanford University Medical School, California 94305, USA
    Curr Biol 15:1235-41. 2005
  8. ncbi Osf2/Cbfa1: a transcriptional activator of osteoblast differentiation
    P Ducy
    Department of Molecular Genetics, M D Anderson Cancer Center, University of Texas, Houston 77030, USA
    Cell 89:747-54. 1997
  9. pmc STIM1, an essential and conserved component of store-operated Ca2+ channel function
    Jack Roos
    Torrey Pines Therapeutics, Inc, La Jolla, CA 92037, USA
    J Cell Biol 169:435-45. 2005
  10. ncbi Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development
    F Otto
    Imperial Cancer Research Fund, Lincoln s Inn Fields, London, United Kingdom
    Cell 89:765-71. 1997

Research Grants

  1. MOLECULAR MECHANISMS OF BACTERIAL PATHOGENESIS
    Robert Collier; Fiscal Year: 2007
  2. Study of Tritonia crawl circuit and ciliated motor cells
    OWEN WOODWARD; Fiscal Year: 2005
  3. Canine model for assessing CNS access P-gp substrates
    KATRINA MEALEY; Fiscal Year: 2005
  4. Molecular Epidemiology of Esophageal Cancer Prognosis
    Geoffrey Liu; Fiscal Year: 2008
  5. Extopic FoxP3 Expression and Diabetogenic T Cells
    Steven Ziegler; Fiscal Year: 2005
  6. KALLIKREINS AS DIAGNOSTIC MARKERS OF OVARIAN CARCINOMA
    Eleftherios Diamandis; Fiscal Year: 2008
  7. CALCIUM SIGNALING ACTIVATION PROCESS OF MICROGLIA CELLS
    Reinhold Penner; Fiscal Year: 2005
  8. Early-onset retinal degenerations
    Samuel Jacobson; Fiscal Year: 2005
  9. MECHANISMS OF WATER TRANSPORT IN RENAL EPITHELIA
    Alan Verkman; Fiscal Year: 2008
  10. Mechanisms of activin antagonism
    Peter Gray; Fiscal Year: 2004

Detail Information

Publications325 found, 100 shown here

  1. pmc Patterns of somatic mutation in human cancer genomes
    Christopher Greenman
    Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK
    Nature 446:153-8. 2007
    ..Systematic sequencing of cancer genomes therefore reveals the evolutionary diversity of cancers and implicates a larger repertoire of cancer genes than previously anticipated...
  2. ncbi Multidrug resistance in cancer: role of ATP-dependent transporters
    Michael M Gottesman
    Laboratory of Cell Biology and Cancer Therapeutics Branch, The Center for Cancer Research, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Rev Cancer 2:48-58. 2002
    ..Therefore, the ability to predict and circumvent drug resistance is likely to improve chemotherapy...
  3. ncbi Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts
    T Komori
    Department of Medicine III, Osaka University Medical School, Suita, Japan
    Cell 89:755-64. 1997
    ....
  4. ncbi The genomic landscapes of human breast and colorectal cancers
    Laura D Wood
    Ludwig Center for Cancer Genetics and Therapeutics and Howard Hughes Medical Institute at Johns Hopkins Kimmel Cancer Center, Baltimore, MD 21231, USA
    Science 318:1108-13. 2007
    ..These results have implications for understanding the nature and heterogeneity of human cancers and for using personal genomics for tumor diagnosis and therapy...
  5. ncbi A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1
    Y Miki
    Department of Medical Informatics, University of Utah Medical Center, Salt Lake City 84132
    Science 266:66-71. 1994
    ..Identification of BRCA1 should facilitate early diagnosis of breast and ovarian cancer susceptibility in some individuals as well as a better understanding of breast cancer biology...
  6. ncbi Neuroblastoma: biological insights into a clinical enigma
    Garrett M Brodeur
    Division of Oncology, The Children s Hospital of Philadelphia and the University of Pennsylvania, Philadelphia, Pennsylvania 19104 4318, USA
    Nat Rev Cancer 3:203-16. 2003
    ..Future therapies will focus increasingly on the genes and biological pathways that contribute to malignant transformation or progression...
  7. pmc STIM is a Ca2+ sensor essential for Ca2+-store-depletion-triggered Ca2+ influx
    Jen Liou
    Department of Molecular Pharmacology, Stanford University Medical School, California 94305, USA
    Curr Biol 15:1235-41. 2005
    ..Our study suggests that STIM proteins function as Ca(2+) store sensors in the signaling pathway connecting Ca(2+) store depletion to Ca(2+) influx...
  8. ncbi Osf2/Cbfa1: a transcriptional activator of osteoblast differentiation
    P Ducy
    Department of Molecular Genetics, M D Anderson Cancer Center, University of Texas, Houston 77030, USA
    Cell 89:747-54. 1997
    ..This study identifies Osf2/Cbfa1 as an osteoblast-specific transcription factor and as a regulator of osteoblast differentiation...
  9. pmc STIM1, an essential and conserved component of store-operated Ca2+ channel function
    Jack Roos
    Torrey Pines Therapeutics, Inc, La Jolla, CA 92037, USA
    J Cell Biol 169:435-45. 2005
    ..We propose that STIM1, a ubiquitously expressed protein that is conserved from Drosophila to mammalian cells, plays an essential role in SOC influx and may be a common component of SOC and CRAC channels...
  10. ncbi Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development
    F Otto
    Imperial Cancer Research Fund, Lincoln s Inn Fields, London, United Kingdom
    Cell 89:765-71. 1997
    ..Thus, the Cbfa1 gene is essential for osteoblast differentiation and bone formation, and the Cbfa1 heterozygous mouse is a paradigm for a human skeletal disorder...
  11. pmc Repeated observation of breast tumor subtypes in independent gene expression data sets
    Therese Sorlie
    Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 100:8418-23. 2003
    ..Our results strongly support the idea that many of these breast tumor subtypes represent biologically distinct disease entities...
  12. ncbi Integrative genomic and proteomic analysis of prostate cancer reveals signatures of metastatic progression
    Sooryanarayana Varambally
    Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    Cancer Cell 8:393-406. 2005
    ....
  13. ncbi TMEM16A, a membrane protein associated with calcium-dependent chloride channel activity
    Antonella Caputo
    Laboratorio di Genetica Molecolare, Istituto Giannina Gaslini, Genova 16148, Italy
    Science 322:590-4. 2008
    ....
  14. ncbi A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma
    G Ambrosini
    Boyer Center for Molecular Medicine, Department of Pathology, Yale University School of Medicine, New Haven, Connecticut 06536, USA
    Nat Med 3:917-21. 1997
    ..These findings suggest that apoptosis inhibition may be a general feature of neoplasia and identify survivin as a potential new target for apoptosis-based therapy in cancer and lymphoma...
  15. pmc The genetic landscape of the childhood cancer medulloblastoma
    D Williams Parsons
    Ludwig Center for Cancer Genetics and Therapeutics and Howard Hughes Medical Institute, Johns Hopkins Kimmel Cancer Center, Baltimore, MD 21231, USA
    Science 331:435-9. 2011
    ....
  16. ncbi Recurrent fusion of TMPRSS2 and ETS transcription factor genes in prostate cancer
    Scott A Tomlins
    Department of Pathology, University of Michigan Medical School, 1301 Catherine Street, Ann Arbor, MI 48109 0602, USA
    Science 310:644-8. 2005
    ..These results have implications in the development of carcinomas and the molecular diagnosis and treatment of prostate cancer...
  17. pmc Identification of conserved gene expression features between murine mammary carcinoma models and human breast tumors
    Jason I Herschkowitz
    Lineberger Comprehensive Cancer Center
    Genome Biol 8:R76. 2007
    ..To address this need, we characterized mammary tumor gene expression profiles from 13 different murine models using DNA microarrays and compared the resulting data to those from human breast tumors...
  18. ncbi The ABC transporter Bcrp1/ABCG2 is expressed in a wide variety of stem cells and is a molecular determinant of the side-population phenotype
    S Zhou
    Division of Experimental Hematology, Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Nat Med 7:1028-34. 2001
    ..These results show that expression of the Bcrp1/ABCG2 gene is an important determinant of the SP phenotype, and that it might serve as a marker for stem cells from various sources...
  19. ncbi IAP-family protein survivin inhibits caspase activity and apoptosis induced by Fas (CD95), Bax, caspases, and anticancer drugs
    I Tamm
    The Burnham Institute, La Jolla, California 92037, USA
    Cancer Res 58:5315-20. 1998
    ..Although quantitative differences may exist, these observations suggest commonality in the mechanisms used by IAP-family proteins to suppress apoptosis...
  20. ncbi Side population is enriched in tumorigenic, stem-like cancer cells, whereas ABCG2+ and ABCG2- cancer cells are similarly tumorigenic
    Lubna Patrawala
    Department of Carcinogenesis, Science Park Research Division, The University of Texas M D Anderson Cancer Center, Smithville, Texas 78957, USA
    Cancer Res 65:6207-19. 2005
    ....
  21. pmc Network-based classification of breast cancer metastasis
    Han Yu Chuang
    Bioinformatics Program, University of California San Diego, La Jolla, CA 92093, USA
    Mol Syst Biol 3:140. 2007
    ..We find that the subnetwork markers are more reproducible than individual marker genes selected without network information, and that they achieve higher accuracy in the classification of metastatic versus non-metastatic tumors...
  22. pmc Oct-4 expression maintained cancer stem-like properties in lung cancer-derived CD133-positive cells
    Yu Chih Chen
    Institute of Clinical Medicine, National Yang Ming University, Taipei, Taiwan
    PLoS ONE 3:e2637. 2008
    ..Future research is warranted regarding the up-regulated expression of Oct-4 in LC-CD133(+) and malignant lung cancer...
  23. pmc PTEN/PI3K/Akt pathway regulates the side population phenotype and ABCG2 activity in glioma tumor stem-like cells
    Anne Marie Bleau
    Department of Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Cell Stem Cell 4:226-35. 2009
    ..This Akt-induced ABCG2 activation results from its transport to the plasma membrane. Temozolomide, the standard treatment of gliomas, although not an ABCG2 substrate, increases the SP in glioma cells, especially in cells missing PTEN...
  24. pmc Lung cancer susceptibility locus at 5p15.33
    James D McKay
    International Agency for Research on Cancer IARC, Lyon, France
    Nat Genet 40:1404-6. 2008
    ..016). The susceptibility region contains two genes, TERT and CLPTM1L, suggesting that one or both may have a role in lung cancer etiology...
  25. ncbi The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation
    J Momand
    Department of Molecular Biology, Lewis Thomas Laboratory, Princeton University, New Jersey 08544 1014
    Cell 69:1237-45. 1992
    ..Thus, a product of the mdm-2 oncogene forms a tight complex with the p53 protein, and the mdm-2 oncogene can inhibit p53-mediated transactivation...
  26. ncbi Linking colorectal cancer to Wnt signaling
    M Bienz
    MRC Laboratory of Molecular Biology, Cambridge, United Kingdom
    Cell 103:311-20. 2000
  27. ncbi Sequence variants at the TERT-CLPTM1L locus associate with many cancer types
    Thorunn Rafnar
    deCODE Genetics, Sturlugata 8, 101 Reykjavik, Iceland
    Nat Genet 41:221-7. 2009
    ..However, neither variant could fully account for the association of the other. rs2736098 corresponds to A305A in the telomerase reverse transcriptase (TERT) protein and rs401681 is in an intron of the CLPTM1L gene...
  28. ncbi Control of apoptosis and mitotic spindle checkpoint by survivin
    F Li
    Boyer Center for Molecular Medicine, Department of Pathology, Yale University School of Medicine, New Haven, Connecticut 06536, USA
    Nature 396:580-4. 1998
    ..The overexpression of survivin in cancer may overcome this apoptotic checkpoint and favour aberrant progression of transformed cells through mitosis...
  29. ncbi Survivin, cancer networks and pathway-directed drug discovery
    Dario C Altieri
    Department of Cancer Biology and the Cancer Center, Lazare Research Building 428, University of Massachusetts Medical School, 364 Plantation Street, Worcester, Massachusetts 01605, USA
    Nat Rev Cancer 8:61-70. 2008
    ..Pursuing the nodal functions of survivin in cancer might lead to the development of global pathway inhibitors with unique therapeutic potential...
  30. pmc Models, mechanisms and clinical evidence for cancer dormancy
    Julio A Aguirre-Ghiso
    Department of Biomedical Sciences, School of Public Health and Center for Excellence in Cancer Genomics, University at Albany, State University of New York, One Discovery Drive, Rensselaer, New York 12144 3456, USA
    Nat Rev Cancer 7:834-46. 2007
    ..The advances in this field provide an emerging picture of how cancer dormancy can ensue and how it could be therapeutically targeted...
  31. ncbi Cancer/testis (CT) antigens: potential targets for immunotherapy
    Otavia L Caballero
    Ludwig Institute for Cancer Research, New York Branch at Memorial Sloan Kettering Cancer Center, New York City, USA
    Cancer Sci 100:2014-21. 2009
    ..Cancer vaccine trials based on CT antigens MAGE-A3 and NY-ESO-1 are currently ongoing, and these antigens may also play a role in antigen-specific adoptive T-cell transfer and in the immunomodulation approach of cancer therapy...
  32. ncbi A gene encoding an antigen recognized by cytolytic T lymphocytes on a human melanoma
    P van der Bruggen
    Ludwig Institute for Cancer Research, Brussels, Belgium
    Science 254:1643-7. 1991
    ..Thus, precisely targeted immunotherapy directed against antigen MZ2-E could be provided to individuals identified by HLA typing and analysis of the RNA of a small tumor sample...
  33. pmc STIM1 clusters and activates CRAC channels via direct binding of a cytosolic domain to Orai1
    Chan Young Park
    Department of Neurobiology, Stanford University School of Medicine, CA 94305, USA
    Cell 136:876-90. 2009
    ..These studies establish a molecular mechanism for store-operated Ca(2+) entry in which the direct binding of STIM1 to Orai1 drives the accumulation and the activation of CRAC channels at ER-PM junctions...
  34. ncbi Validating survivin as a cancer therapeutic target
    Dario C Altieri
    Department of Cancer Biology, LRB 428, University of Massachusetts Medical School, 364 Plantation Street, Worcester, Massachusetts 01605, USA
    Nat Rev Cancer 3:46-54. 2003
    ..Survivin is an attractive candidate for cancer therapy, so what is its potential applicability in the clinic?..
  35. pmc LRPPRC is necessary for polyadenylation and coordination of translation of mitochondrial mRNAs
    Benedetta Ruzzenente
    Department of Mitochondrial Genetics, Max Planck Institute for Biology of Ageing, Cologne, Germany
    EMBO J 31:443-56. 2012
    ..Our findings point to the existence of an elaborate machinery that regulates mammalian mtDNA expression at the post-transcriptional level...
  36. ncbi NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder
    Laetitia Agostini
    Department of Biochemistry, University of Lausanne, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
    Immunity 20:319-25. 2004
    ..Macrophages from Muckle-Wells patients spontaneously secrete active IL-1beta. Increased inflammasome activity is therefore likely to be the molecular basis of the symptoms associated with NALP3-dependent autoinflammatory disorders...
  37. pmc A multidrug resistance transporter from human MCF-7 breast cancer cells
    L A Doyle
    Greenebaum Cancer Center of the University of Maryland, Baltimore MD 21201, USA
    Proc Natl Acad Sci U S A 95:15665-70. 1998
    ..BCRP is a xenobiotic transporter that appears to play a major role in the multidrug resistance phenotype of MCF-7/AdrVp human breast cancer cells...
  38. pmc TMEM16A induces MAPK and contributes directly to tumorigenesis and cancer progression
    Umamaheswar Duvvuri
    Department of Otolaryngology, University of Pittsburgh Medical Center, University of Pittsburgh School of Medicine and Magee Women s Research Institute, Pittsburgh, Pennsylvania 15213, USA
    Cancer Res 72:3270-81. 2012
    ..The development of small-molecule inhibitors against TMEM16A may be clinically relevant for treatment of human cancers, including SCCHN...
  39. ncbi Mule/ARF-BP1, a BH3-only E3 ubiquitin ligase, catalyzes the polyubiquitination of Mcl-1 and regulates apoptosis
    Qing Zhong
    Howard Hughes Medical Institute and Department of Biochemistry, University of Texas Southwestern Medical Center at Dallas, 75390, USA
    Cell 121:1085-95. 2005
    ..Thus, Mule is a unique BH3-containing E3 ubiquitin ligase apical to Bcl-2 family proteins during DNA damage-induced apoptosis...
  40. pmc Prostate stem cell antigen: a cell surface marker overexpressed in prostate cancer
    R E Reiter
    Department of Urology, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 95:1735-40. 1998
    ..A mouse homologue with 70% amino acid identity and similar genomic organization to human PSCA has also been identified. These results support PSCA as a target for prostate cancer diagnosis and therapy...
  41. pmc Oncomine 3.0: genes, pathways, and networks in a collection of 18,000 cancer gene expression profiles
    Daniel R Rhodes
    Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109 0940, USA
    Neoplasia 9:166-80. 2007
    ..Here, we provide an update on the initiative, describe the database and analysis modules, and highlight several notable observations. Results from this comprehensive analysis are available at http://www.oncomine.org...
  42. ncbi Mammalian drug efflux transporters of the ATP binding cassette (ABC) family: an overview
    Alfred H Schinkel
    Division of Experimental Therapy, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    Adv Drug Deliv Rev 55:3-29. 2003
    ..We aim to provide an overview of properties of the mammalian ABC transporters known to mediate significant transport of clinically relevant drugs...
  43. ncbi Cancer stem cells in solid tumors
    Laurie E Ailles
    Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, 1050 Arastradero Road, Palo Alto, CA 94304, United States
    Curr Opin Biotechnol 18:460-6. 2007
    ..Thus the biological properties of CSCs are just beginning to be revealed, and the continuation of these studies should lead to the development of CSC-targeted therapies for cancer treatment...
  44. ncbi Molecular chaperones and the stress of oncogenesis
    Dick D Mosser
    Department of Molecular Biology and Genetics, University of Guelph, Guelph, Ontario, Canada N1G 2W1
    Oncogene 23:2907-18. 2004
    ..The involvement of chaperones, therefore, in such diverse roles might suggest novel anticancer therapeutic approaches targeting heat-shock protein function for a broad spectrum of tumor types...
  45. ncbi Molecular classification of cancer: class discovery and class prediction by gene expression monitoring
    T R Golub
    Whitehead Institute Massachusetts Institute of Technology Center for Genome Research, Cambridge, MA 02139, USA
    Science 286:531-7. 1999
    ....
  46. ncbi The inhibitors of apoptosis (IAPs) and their emerging role in cancer
    E C LaCasse
    Apoptogen Inc, CHEO Research Institute, Ottawa, Ontario, Canada
    Oncogene 17:3247-59. 1998
    ..Overall a picture consistent with an IAP role in tumour progression rather than tumour initiation is emerging making the IAPs an attractive therapeutic target...
  47. ncbi Identification of cancer stem cell-like side population cells in human nasopharyngeal carcinoma cell line
    Jing Wang
    State Key Laboratory of Oncology in Southern China and Department of Experimental Research, Sun Yat sen University Cancer Center, 651 Dongfeng Road East, Guangzhou 510 060, P R China
    Cancer Res 67:3716-24. 2007
    ..Taken together, our data shed light on tumorigenesis and therapeutic-resistant mechanisms, which are helpful for developing novel targets for effective clinical treatment of NPC...
  48. ncbi Hox cofactors in vertebrate development
    Cecilia B Moens
    Division of Basic Science and HHMI, Fred Hutchinson Cancer Research Center, Seattle, WA 98115, USA
    Dev Biol 291:193-206. 2006
    ....
  49. ncbi Association of the APC gene product with beta-catenin
    B Rubinfeld
    Onyx Pharmaceuticals, Richmond, CA 94806
    Science 262:1731-4. 1993
    ..An antibody specific to beta-catenin also recognized the 95-kilodalton protein in the immunoprecipitates. These results suggest that APC is involved in cell adhesion...
  50. pmc Cancer regression in patients after transfer of genetically engineered lymphocytes
    Richard A Morgan
    Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA
    Science 314:126-9. 2006
    ..This study suggests the therapeutic potential of genetically engineered cells for the biologic therapy of cancer...
  51. doi Genetic variation in PSCA is associated with susceptibility to diffuse-type gastric cancer
    Hiromi Sakamoto
    Nat Genet 40:730-40. 2008
    ..90, 95% CI = 1.56-2.33, P = 8.01 x 10(-11)). The polymorphism of the PSCA gene, which is possibly involved in regulating gastric epithelial-cell proliferation, influences susceptibility to diffuse-type gastric cancer...
  52. ncbi Melanoma contains CD133 and ABCG2 positive cells with enhanced tumourigenic potential
    Elena Monzani
    Department of Biomolecular Science and Biotechnology, University of Milan, Milan, Italy
    Eur J Cancer 43:935-46. 2007
    ..Interestingly, considering that melanoma gives metastasis primarily through lymphatic vessels, herein, we demonstrated that a melanoma cell line expresses typical lymphoangiogenic factors...
  53. ncbi The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation
    Kazuhisa Nakashima
    Department of Molecular Genetics and Program in Genes and Development, M D Anderson Cancer Center, University of Texas, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Cell 108:17-29. 2002
    ..Thus, Osx acts downstream of Runx2/Cbfa1. Because Osx null preosteoblasts express typical chondrocyte marker genes, we propose that Runx2/Cbfa1-expressing preosteoblasts are still bipotential cells...
  54. ncbi Chromosomal translocation t(15;17) in human acute promyelocytic leukemia fuses RAR alpha with a novel putative transcription factor, PML
    A Kakizuka
    Salk Institute for Biological Studies, La Jolla, California 92037
    Cell 66:663-74. 1991
    ..Treatment with RA would not only relieve this inhibition, but the activated PML-RAR protein may actually promote myelocyte differentiation...
  55. ncbi PML regulates p53 acetylation and premature senescence induced by oncogenic Ras
    M Pearson
    European Institute of Oncology, Department of Experimental Oncology, Milan, Italy
    Nature 406:207-10. 2000
    ..Our data establish a link between PML and p53 and indicate that integrity of the PML bodies is required for p53 acetylation and senescence upon oncogene expression...
  56. ncbi A phosphatase associated with metastasis of colorectal cancer
    S Saha
    Howard Hughes Medical Institute, The Oncology Center, Department of Surgery, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
    Science 294:1343-6. 2001
    ..3. These data suggest that the PRL-3 gene is important for colorectal cancer metastasis and provide a new therapeutic target for these intractable lesions...
  57. ncbi To cycle or not to cycle: a critical decision in cancer
    M Malumbres
    Molecular Oncology Program, Centro Nacional de Investigaciones Oncologicas, Madrid, Spain
    Nat Rev Cancer 1:222-31. 2001
    ..Understanding the molecular mechanisms that underlie this commitment should provide important insights into how normal cells become tumorigenic and how new anticancer strategies can be devised...
  58. pmc Elimination of Mcl-1 is required for the initiation of apoptosis following ultraviolet irradiation
    Deepak Nijhawan
    Howard Hughes Medical Institute and Department of Biochemistry, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA
    Genes Dev 17:1475-86. 2003
    ..The disappearance of Mcl-1 is also required for other mitochondrial apoptotic events including Bax translocation, cytochrome c release, and caspase activation...
  59. ncbi Transcriptional repression of the anti-apoptotic survivin gene by wild type p53
    William H Hoffman
    Department of Pharmacology, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    J Biol Chem 277:3247-57. 2002
    ..The identification of survivin as a p53 repressed gene should aid in the elucidation of the contribution of transcriptional repression to p53-dependent apoptosis...
  60. pmc Novel genetic variants in the chromosome 5p15.33 region associate with lung cancer risk
    Mala Pande
    Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Carcinogenesis 32:1493-9. 2011
    ..Results of these analyses strongly suggest effects on risk from several loci in the TERT/CLPTM1L region...
  61. pmc Calcium store sensor stromal-interaction molecule 1-dependent signaling plays an important role in cervical cancer growth, migration, and angiogenesis
    Yih Fung Chen
    Department of Pharmacology, National Cheng Kung University, Tainan 70101, Taiwan
    Proc Natl Acad Sci U S A 108:15225-30. 2011
    ..These results make STIM1-dependent signaling an attractive target for therapeutic intervention...
  62. ncbi The ABCG2 transporter is an efficient Hoechst 33342 efflux pump and is preferentially expressed by immature human hematopoietic progenitors
    Christian W Scharenberg
    Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Blood 99:507-12. 2002
    ..Furthermore, the sharp down-regulation of ABCG2 at the stage of lineage commitment suggests that this gene may play an important role in the unique physiology of the pluripotent stem cell...
  63. ncbi Prostate stem cell antigen (PSCA) expression increases with high gleason score, advanced stage and bone metastasis in prostate cancer
    Z Gu
    Department of Urology, University of California, Los Angeles, California, CA 90095, USA
    Oncogene 19:1288-96. 2000
    ..Because expression on the surface of prostate cancer cells increases with tumor progression, PSCA may be a useful molecular target in advanced prostate cancer...
  64. ncbi Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function
    Lin Chen
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville Victoria 3050, Australia
    Mol Cell 17:393-403. 2005
    ..The results suggest that apoptosis relies on selective interactions between particular subsets of these proteins and that it should be feasible to discover BH3-mimetic drugs that inactivate specific prosurvival targets...
  65. ncbi Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases
    H Zhong
    The Johns Hopkins Oncology Center, Brady Urological Institute, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Cancer Res 59:5830-5. 1999
    ..In brain tumors, HIF-1alpha immunohistochemistry demarcated areas of angiogenesis. These results provide the first clinical data indicating that HIF-1alpha may play an important role in human cancer progression...
  66. pmc Inhibition of NF-kappaB signaling by A20 through disruption of ubiquitin enzyme complexes
    Noula Shembade
    Department of Microbiology and Immunology, Sylvester Comprehensive Cancer Center, The University of Miami, Miller School of Medicine, Miami, FL 33136, USA
    Science 327:1135-9. 2010
    ..These findings suggest mechanism of A20 action in the inhibition of inflammatory signaling pathways...
  67. pmc Identification of a gene causing human cytochrome c oxidase deficiency by integrative genomics
    Vamsi K Mootha
    Whitehead Institute Massachusetts Institute of Technology Center for Genome Research, One Kendall Square, Building 300, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 100:605-10. 2003
    ..Similar strategies to integrate diverse genomic information can be applied likewise to other disease pathways and will become increasingly powerful with the growing wealth of diverse, functional genomics data...
  68. ncbi A family of drug transporters: the multidrug resistance-associated proteins
    P Borst
    Division of Molecular Biology and Center of Biomedical Genetics, The Netherlands Cancer Institute, Amsterdam
    J Natl Cancer Inst 92:1295-302. 2000
    ..The physiologic functions of the other MRPs are not known. Whether long-term inhibition of MRPs in humans can be tolerated (assuming that suitable inhibitors will be found) remains to be determined...
  69. pmc Role of promyelocytic leukemia (PML) protein in tumor suppression
    E M Rego
    Department of Human Genetics and Molecular Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Exp Med 193:521-29. 2001
    ....
  70. ncbi A multigenic program mediating breast cancer metastasis to bone
    Yibin Kang
    Cell Biology Program and Howard Hughes Medical Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Cancer Cell 3:537-49. 2003
    ....
  71. pmc New common variants affecting susceptibility to basal cell carcinoma
    Simon N Stacey
    deCODE Genetics, Reykjavik, Iceland
    Nat Genet 41:909-14. 2009
    ..Finally, we report conclusive evidence that rs401681[C] in the TERT-CLPTM1L locus confers susceptibility to BCC but protects against melanoma...
  72. ncbi Side population cells in human cancers
    Colleen Wu
    Program in Developmental and Stem Cell Biology, Hospital for Sick Children, University of Toronto, Toronto Medical Discovery Tower, East Tower, 101 College Street, Toronto, Ont, Canada M5G 1L7
    Cancer Lett 268:1-9. 2008
    ..Dye exclusion is a valuable technique as it identifies a unique population of cells with stem-like characteristics...
  73. ncbi CRACM1 multimers form the ion-selective pore of the CRAC channel
    Monika Vig
    Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Curr Biol 16:2073-9. 2006
    ..Our data provide unequivocal evidence that CRACM1 multimers form the Ca(2+)-selective CRAC-channel pore...
  74. pmc Centriolar satellites are assembly points for proteins implicated in human ciliopathies, including oral-facial-digital syndrome 1
    Carla A M Lopes
    Department of Biochemistry, University of Leicester, Lancaster Road, Leicester LE1 9HN, UK
    J Cell Sci 124:600-12. 2011
    ..Furthermore, definition of how OFD1 and PCM-1 interact helps explain why different OFD1 mutations lead to clinically variable phenotypes...
  75. pmc LRPPRC and SLIRP interact in a ribonucleoprotein complex that regulates posttranscriptional gene expression in mitochondria
    Florin Sasarman
    Department of Human Genetics, Montreal Neurological Institute, McGill University, Montreal, QC, H3A 2B4, Canada
    Mol Biol Cell 21:1315-23. 2010
    ..These results implicate LRPPRC in posttranscriptional mitochondrial gene expression as part of a ribonucleoprotein complex that regulates the stability and handling of mature mRNAs...
  76. ncbi Dynamic modularity in protein interaction networks predicts breast cancer outcome
    Ian W Taylor
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Ave, Toronto, Ontario M5G 1X5, Canada
    Nat Biotechnol 27:199-204. 2009
    ..Analysis of two breast cancer patient cohorts revealed that altered modularity of the human interactome may be useful as an indicator of breast cancer prognosis...
  77. ncbi Survivin and molecular pathogenesis of colorectal cancer
    Paul J Kim
    Department of Cancer Biology and the Cancer Center, University of Massachusetts, Medical School, Worcester, MA, USA
    Lancet 362:205-9. 2003
    ..Survivin is a bifunctional regulator of cell death and cell proliferation expressed during embryonic development but undetectable in healthy adult tissues and re-expressed in many cancers, including colorectal cancer...
  78. ncbi Aldehyde dehydrogenase discriminates the CD133 liver cancer stem cell populations
    Stephanie Ma
    Department of Clinical Oncology, The University of Hong Kong, Pokfulam, Hong Kong, China
    Mol Cancer Res 6:1146-53. 2008
    ..ALDH, expressed along CD133, can more specifically characterize the tumorigenic liver CSC population...
  79. ncbi Structural basis for viral 5'-PPP-RNA recognition by human IFIT proteins
    Yazan M Abbas
    Department of Biochemistry, Groupe de recherche axé sur la structure des protéines, McGill University, Montreal, Quebec H3G 0B1, Canada
    Nature 494:60-4. 2013
    ..These results demonstrate the mechanism by which IFIT proteins selectively recognize viral RNA, and lend insight into their downstream effector function...
  80. ncbi ID1 and ID3 regulate the self-renewal capacity of human colon cancer-initiating cells through p21
    Catherine A O'Brien
    Campbell Family Institute, Ontario Cancer Institute, Princess Margaret Hospital, University Health Network, Toronto, Ontario M5G 1L7, Canada
    Cancer Cell 21:777-92. 2012
    ..Additionally, silencing of ID1 and ID3 increases sensitivity of CC-ICs to the chemotherapeutic agent oxaliplatin, linking tumor initiation function with chemotherapy resistance...
  81. pmc Decreased extra-renal urate excretion is a common cause of hyperuricemia
    Kimiyoshi Ichida
    Department of Pathophysiology, Tokyo University of Pharmacy and Life Sciences, 1432 1 Horinouchi, Hachiouji, Tokyo 192 0392, Japan
    Nat Commun 3:764. 2012
    ....
  82. ncbi Identification of a vertebrate sister-chromatid separation inhibitor involved in transformation and tumorigenesis
    H Zou
    Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA
    Science 285:418-22. 1999
    ..The oncogenic nature of increased expression of vSecurin may result from chromosome gain or loss, produced by errors in chromatid separation...
  83. ncbi The prostate stem cell antigen represents a novel glioma-associated antigen
    K D Geiger
    Department of Neuropathology, Institute for Pathology, Medical Faculty Carl Gustav Carus, D 01307 Dresden, Germany
    Oncol Rep 26:13-21. 2011
    ..001). Our results suggest that increased PSCA expression levels are linked to gliomas of WHO grades III and IV, and may represent a suitable additional target for immunotherapy of gliomas...
  84. pmc LIV-1 promotes prostate cancer epithelial-to-mesenchymal transition and metastasis through HB-EGF shedding and EGFR-mediated ERK signaling
    Hui Wen Lue
    Department of Biology, Georgia State University, Atlanta, Georgia, United States of America
    PLoS ONE 6:e27720. 2011
    ..LIV-1 could be an attractive therapeutic target for the eradication of pre-existing human prostate cancer and bone and soft tissue metastases...
  85. ncbi Replication stress induces sister-chromatid bridging at fragile site loci in mitosis
    Kok Lung Chan
    Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DS, UK
    Nat Cell Biol 11:753-60. 2009
    ..Our data have general implications concerning the contribution of fragile site loci to chromosomal instability and tumorigenesis...
  86. ncbi Orai1 and STIM1 are critical for breast tumor cell migration and metastasis
    Shengyu Yang
    Department of Physiology, Weill Medical College of Cornell University, New York, NY 10065, USA
    Cancer Cell 15:124-34. 2009
    ..Our data demonstrate a role for Orai1 and STIM1 in tumor metastasis and suggest store-operated calcium entry channels as potential cancer therapeutic targets...
  87. ncbi PML protein isoforms and the RBCC/TRIM motif
    K Jensen
    Centre for Structural Biology, Imperial College of Science, Technology and Medicine, Flowers Building, Armstrong Road, London SW7 2AZ, UK
    Oncogene 20:7223-33. 2001
    ..In APL oligomerization mediated by the RBCC/TRIM motif is essential for the transformation potential of the PML-RARalpha fusion protein...
  88. ncbi PML is essential for multiple apoptotic pathways
    Z G Wang
    Department of Human Genetics and Molecular Biology Program, Memorial Sloan Kettering Cancer Center, Graduate School of Medical Sciences, Cornell University, New York, New York 10021, USA
    Nat Genet 20:266-72. 1998
    ..These results demonstrate that Pml is a mediator of multiple apoptotic signals, and implicate inhibition of apoptosis in the pathogenesis of APL...
  89. ncbi Clinical significance of prostate stem cell antigen expression in non-small cell lung cancer
    Takeshi Kawaguchi
    Department of Thoracic and Cardiovascular Surgery, Nara Medical University, Kashihara, Nara, Japan
    Jpn J Clin Oncol 40:319-26. 2010
    ..In this study, we investigated the clinical significance and therapeutic potential of prostate stem cell antigen expression in non-small cell lung cancer...
  90. ncbi A candidate prostate cancer susceptibility gene at chromosome 17p
    S V Tavtigian
    Myriad Genetics, Inc, Salt Lake City, Utah, USA
    Nat Genet 27:172-80. 2001
    ....
  91. pmc Cancer regression and autoimmunity in patients after clonal repopulation with antitumor lymphocytes
    Mark E Dudley
    Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20902, USA
    Science 298:850-4. 2002
    ..This approach presents new possibilities for the treatment of patients with cancer as well as patients with human immunodeficiency virus-related acquired immunodeficiency syndrome and other infectious diseases...
  92. ncbi On the role of Hsp27 in regulating apoptosis
    C G Concannon
    Department of Biochemistry and National Centre for Biomedical Engineering Science, National University of Ireland, Galway, Ireland
    Apoptosis 8:61-70. 2003
    ..This article will review recent advances in the field and will address some of the potential mechanisms by which Hsp27 functions as an anti-apoptotic molecule...
  93. ncbi Longitudinal analysis and prognostic effect of cancer-testis antigen expression in multiple myeloma
    Djordje Atanackovic
    Department of Oncology Hematology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Clin Cancer Res 15:1343-52. 2009
    ....
  94. ncbi The CRAC channel activator STIM1 binds and inhibits L-type voltage-gated calcium channels
    Chan Young Park
    Department of Neurobiology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Science 330:101-5. 2010
    ..This establishes a previously unknown function for STIM1 and provides a molecular mechanism to explain the reciprocal regulation of these two channels in cells...
  95. pmc OS-9 and GRP94 deliver mutant alpha1-antitrypsin to the Hrd1-SEL1L ubiquitin ligase complex for ERAD
    John C Christianson
    Department of Biological Sciences and Bio X Program, Stanford University, Lorry Lokey Bldg, 337 Campus Drive, Stanford, CA 94305, USA
    Nat Cell Biol 10:272-82. 2008
    ..These data suggest that XTP3-B and OS-9 are components of distinct, partially redundant, quality control surveillance pathways that coordinate protein folding with membrane dislocation and ubiquitin conjugation in mammalian cells...
  96. pmc A Cytosolic Homomerization and a Modulatory Domain within STIM1 C Terminus Determine Coupling to ORAI1 Channels
    Martin Muik
    Institute of Biophysics, University of Linz, A 4040 Linz
    J Biol Chem 284:8421-6. 2009
    ....
  97. ncbi Down-modulation of keratin 8 phosphorylation levels by PRL-3 contributes to colorectal carcinoma progression
    Eri Mizuuchi
    Department of Pathology, Division of Pathology, Kobe University Graduate School of Medicine, Kobe, Japan
    Int J Cancer 124:1802-10. 2009
    ..In conclusion, our results indicate that PRL-3 may play an important role for the promotion of CRC cell migration and metastatic potential through direct KRT8 dephosphorylation...
  98. ncbi Synuclein-gamma (SNCG) may be a novel prognostic biomarker in uterine papillary serous carcinoma
    Jacqueline Morgan
    Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Gynecol Oncol 114:293-8. 2009
    ..We set out to determine if SNCG expression in UPSC correlates with aggressive cellular properties, poor prognosis, and chemoresistance, and if silencing SNCG can reverse these attributes in vitro...
  99. pmc A Cbfa1-dependent genetic pathway controls bone formation beyond embryonic development
    P Ducy
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Genes Dev 13:1025-36. 1999
    ....
  100. pmc Analytical methods for inferring functional effects of single base pair substitutions in human cancers
    William Lee
    Department of Bioinformatics, Genentech, Inc, 1 DNA Way, M S 93, South San Francisco, CA 94080, USA
    Hum Genet 126:481-98. 2009
    ..We also review current knowledge and tools that can be utilized for analysis of alterations in non-protein-coding genomic sequence...
  101. pmc Mice lacking dystrophin or alpha sarcoglycan spontaneously develop embryonal rhabdomyosarcoma with cancer-associated p53 mutations and alternatively spliced or mutant Mdm2 transcripts
    Karen Fernandez
    Division of Hematology Oncology, Nationwide Children s Hospital, Columbus, Ohio 43205, USA
    Am J Pathol 176:416-34. 2010
    ....

Research Grants77

  1. MOLECULAR MECHANISMS OF BACTERIAL PATHOGENESIS
    Robert Collier; Fiscal Year: 2007
    ..abstract_text> ..
  2. Study of Tritonia crawl circuit and ciliated motor cells
    OWEN WOODWARD; Fiscal Year: 2005
    ..This project may also contribute to the understanding and treatment of motor system disorders as well as demonstrate how the CNS may control non-muscular motor behaviors. ..
  3. Canine model for assessing CNS access P-gp substrates
    KATRINA MEALEY; Fiscal Year: 2005
    ....
  4. Molecular Epidemiology of Esophageal Cancer Prognosis
    Geoffrey Liu; Fiscal Year: 2008
    ..Furthermore, the proposed studies address directly a prioritized research area identified by the NCI Stomach and Esophageal Cancers Progress Review Group (Year 2002). ..
  5. Extopic FoxP3 Expression and Diabetogenic T Cells
    Steven Ziegler; Fiscal Year: 2005
    ..These experiments will provide valuable information on the efficacy of FoxP3 as a tool for therapeutic intervention in autoimmune diabetes. ..
  6. KALLIKREINS AS DIAGNOSTIC MARKERS OF OVARIAN CARCINOMA
    Eleftherios Diamandis; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  7. CALCIUM SIGNALING ACTIVATION PROCESS OF MICROGLIA CELLS
    Reinhold Penner; Fiscal Year: 2005
    ..abstract_text> ..
  8. Early-onset retinal degenerations
    Samuel Jacobson; Fiscal Year: 2005
    ....
  9. MECHANISMS OF WATER TRANSPORT IN RENAL EPITHELIA
    Alan Verkman; Fiscal Year: 2008
    ..Methods will include fluorescence photobleaching recovery, energy transfer and ratio imaging. Also, specific water/solute transporting properties (Pd, c^)of the mammalian aquaporins will be measured. ..
  10. Mechanisms of activin antagonism
    Peter Gray; Fiscal Year: 2004
    ..Together, these experiments will further elucidate mechanisms of activating antagonism to provide a basis for the development of tools and reagents to treat pituitary and reproductive disorders. ..
  11. Diphtheria fusion protein therapy of AML
    ARTHUR FRANKEL; Fiscal Year: 2006
    ..These studies should lead to the design of pivotal phase II clinical trials to determine the role of this therapeutic in AML management. ..
  12. Influence of P-glycoprotein in treating brain tumors
    Donald Miller; Fiscal Year: 2006
    ..These studies will provide a critical assessment of the role of P-gp in the limited effectiveness of selected chemotherapeutic agents in treating brain tumors. ..
  13. FoxP3 control of peripheral regulatory T cell generation
    Steven Ziegler; Fiscal Year: 2007
    ..The experiments will also begin to test the feasibility of manipulating FoxP3 expression as a means of treating autoimmune disease. [unreadable] [unreadable] [unreadable]..
  14. A Comprehensive Analysis of Genetic Variation in DNA Repair Genes in Relation to
    Christopher Haiman; Fiscal Year: 2007
    ..The ability to accurately identify high-risk sub-groups may have profound implications on endometrial cancer prevention as well as advance research aimed at targeted drug development. [unreadable] [unreadable] [unreadable]..
  15. Bimp3 in Antigen Receptor Signaling and MALT Lymphoma
    LINDA MCALLISTER LUCAS; Fiscal Year: 2007
    ..This training experience will ultimately lead to transition to the status of independent investigator. ..
  16. MECHANICS AND FUNCTIONS OF THE N-END RULE PATHWAY
    Alexander Varshavsky; Fiscal Year: 2007
    ..cerevisiae. ..
  17. Radioimmunotherapy for Prostate Cancer
    Michael Morris; Fiscal Year: 2007
    ..The acquisition of these skills combined with the completion of the research plan will allow the candidate to pursue such research independently. ..
  18. Vasculature is a determinant of epithelial morphogenesis
    MARGARET SCHWARZ; Fiscal Year: 2006
    ..Thus, identifying the factors responsible for coordinating vascular formation and distal lung morphogenesis will provide insight into the determinants by which their balance can affect lung development. ..
  19. Novel Anticoagulant Mechanisms
    MARY HEEB; Fiscal Year: 2006
    ..We will find whether a ZPI polymorphism we identified affects function. ..
  20. Structural Basis of Novel Hookworm Vaccines
    Oluwatoyin Asojo; Fiscal Year: 2006
    ..56 Angstroms (protein data bank code 1U53). In addition, a 2 PR-1 domain ASP (Na-ASP-1) has been crystallized with data up to 2.7 Angstroms. [unreadable] [unreadable] [unreadable]..
  21. FOXP3: functional analysis of the gene mutated in mice
    Steven Ziegler; Fiscal Year: 2006
    ..These analyses will shed light on the regulatory pathways involved in the development of autoimmune disease, and will serve as a model for human immune-system abnormalities. ..
  22. Targeting protein synthesis in AML
    ARTHUR FRANKEL; Fiscal Year: 2006
    ..These studies will hopefully lead to the design of pivotal phase II and III clinical trials which will define the role of DT388IL3 in the management of AML. ..
  23. 2004 Hemostasis Gordon Research Conference
    Edward Plow; Fiscal Year: 2004
    ..The Hemostasis Gordon Conference has been a highly successful and enjoyable meeting, frequently identified as the best meeting attended by participants; and we believe that the current program has the potential to extend this tradition. ..
  24. Thrombospondins and Atherothrombosis
    Edward Plow; Fiscal Year: 2004
    ..Together, these studies should provide a rigorous test of the hypothesis and extend our knowledge of the roles of the TSPs in cardiovascular biology. ..
  25. Fine-mapping of 8q24 and Loci Identified in Genome-Wide Studies for Breast & Colo
    CHRISTOPHER ALAN HAIMAN; Fiscal Year: 2010
    ..We expect findings from this work to guide the development of future preventive, early detection and prognostic strategies ..
  26. Human Kallikrein 4 (hK4): A New Prostatic Biomarker?
    Eleftherios Diamandis; Fiscal Year: 2003
    ..If successful, our research will contribute to the development of new prostatic biomarkers and possibly, to better diagnosis which may lead to better clinical outcomes and reduced healthcare costs. ..
  27. EXPRESSION OF HUMAN ERYTHROPOIETIN GENE
    Gregg Semenza; Fiscal Year: 2002
    ..abstract_text> ..
  28. Combination fusion toxin and cytarabine therapy of AML
    ARTHUR FRANKEL; Fiscal Year: 2002
    ..We anticipate these studies should provide the basis for the design and implementation of pivotal multi-institutional phase II and III trials of DTGM/cytarabine therapy for relapsed/refractory AML. ..
  29. AUTOANTIBODIES AS MARKERS OF BREAST CANCER
    FELIX FERNANDEZ MADRID; Fiscal Year: 2002
    ..Associations will be sought between serum reactivities, patient diagnosis and existing ten-year outcome data to assess the potential diagnostic and prognostic value of each antigen. ..
  30. Role of airway submucosal glands in CF lung disease
    Alan S Verkman; Fiscal Year: 2010
    ..The data will provide a rigorous scientific rationale for use of small-molecules in CF therapy, and establish widely useful assays to prioritize small molecules for clinical development. ..
  31. PATHOGENESIS OF RETINAL DEGENERATIONS
    Samuel Jacobson; Fiscal Year: 2001
    ..The results of this research will lead to the formulation of hypotheses about the underlying molecular events in these diseases and may evolve into recommendations for treatment paradigms in these blinding retinal degenerations. ..
  32. Molecular and functional properties of the TRPM2 catioin channel
    Reinhold Penner; Fiscal Year: 2010
    ....
  33. FACS VANTAGE/SE
    Steven Ziegler; Fiscal Year: 2001
    ..Finally, there is a need for an instrument capable of doing DNA content and Ca2+- flux analyses. The instrument requested will provide for the current, as well as future, needs of the user group...
  34. FORMS OF PROSTATE SPECIFIC ANTIGEN AND HK2 IN CANCER
    MARY HEEB; Fiscal Year: 2003
    ..Techniques will include protein purification, antibody and ELISA development, immunoblotting, enzyme activity assays, and peptide synthesis. ..
  35. Development and Validation of a Panel of Breast Cancer for the Early Diagnosis of
    FELIX RODOLFO FERNANDEZ MADRID; Fiscal Year: 2010
    ..We propose that this test used in conjunction with mammography has the potential to complement and increase the accuracy of the screening process. ..
  36. Mucociliary Function in Chronic Bronchitis
    MATTHIAS A SALATHE; Fiscal Year: 2010
    ..The results of the proposed experiments, using novel and state-of-the-art methods, will provide new and important mechanistic insights into the regulation of mucociliary clearance in chronic bronchitis. ..
  37. Hypoxia-Inducible Factor 1 and Oxygen Homeostasis
    Gregg Semenza; Fiscal Year: 2009
    ....
  38. Ubiquitin Ligases, Mechanisms and Functions of the N-End Rule Pathway
    Alexander Varshavsky; Fiscal Year: 2008
    ..5) New components and functions of the deamidation branch of the N-end rule pathway: isolation, cloning and molecular genetic dissection of mouse NTAQ1, a glutamine-specific N-terminal amidase. ..
  39. ANGIOCIDIN, A NEW ANGIOGENESIS INHIBITOR
    George Tuszynski; Fiscal Year: 2004
    ..Finally, these experiments should provide the basis for the development of angiocidin as an anti-cancer therapeutic. ..
  40. Signaling Pathways in Salivary Gland Fluid Secretion
    Trevor Shuttleworth; Fiscal Year: 2009
    ..abstract_text> ..
  41. Cysteine String Protein and Acute Pancreatitis
    GUY GROBLEWSKI; Fiscal Year: 2004
    ..These studies will allow us to directly evaluate the role of CSP in the secretory pathway of acini under physiological and pathophysiological conditions. ..
  42. LEUKOCYTE INTEGRIN ALPHA M BETA 2
    Edward Plow; Fiscal Year: 2004
    ....
  43. Molecular Targeting of the Survivin Pathway in Cancer
    Dario C Altieri; Fiscal Year: 2010
    ..This work will provide a mechanistic foundation for the validation and further development of molecular antagonists of the survivin pathway for novel cancer therapeutics in humans. ..
  44. THE STRUCTURE AND FUNCTION OF PLATELET GPIIB-IIIA
    Edward Plow; Fiscal Year: 2003
    ..At the same time, these studies may have direct bearing on the use and future development of the GPIIb-IIIa blockers as antithrombotic agents. ..
  45. CD44/VARIANT CYTOSKELETON IN BREAST CANCER PROGRESSION
    LILLY YW BOURGUIGNON; Fiscal Year: 2010
    ....
  46. Crosstalk between oncoprotein Ski and TGF-B signaling
    Yin Sun; Fiscal Year: 2008
    ..abstract_text> ..
  47. TSLP receptor in the regulation of cell development
    Steven F Ziegler; Fiscal Year: 2010
    ..abstract_text> ..
  48. Inositol (1,4,5) trisphoshate response thresholds
    Reinhold Penner; Fiscal Year: 2008
    ..This compartment is notable for its low sensitivity (i.e., high threshold) to InsP3. ..
  49. FUNCTIONAL CHARACTERIZATION OF CD69
    Steven Ziegler; Fiscal Year: 2003
    ..Knowing this information will allow a detailed analysis of the role of CD69 in the initiation and propagation of autoimmune disease to be initiated. ..
  50. The Role of FoxP3 in Regulatory T Cell Function
    Steven Ziegler; Fiscal Year: 2005
    ..The experiments will also begin to test the feasibility of manipulating FoxP3 expression as a means of treating autoimmune disease. ..
  51. Development of Digital SNP Analysis in Cancer Detection
    Ie Ming Shih; Fiscal Year: 2005
    ..Thus, the encouraging results from this study will ensure the detection of AI in plasma a promising cancer research direction for further exploration. ..
  52. A New Biomarker for Ovarian Cancer Detection
    Eleftherios Diamandis; Fiscal Year: 2003
    ..In this grant proposal, we describe further studies, which will examine in greater detail, the ability of a test for the amount of this protein in blood to correctly diagnose the presence of ovarian cancer. ..
  53. IPEX and Scurfin/FoxP3: Dysregulation of T cells
    Steven Ziegler; Fiscal Year: 2004
    ..These analyses will shed light on the regulatory pathways involved in the development of autoimmune disease, and will serve as a model for human immune-system abnormalities. ..
  54. Novel Proapoptotic BH3-only Proteins in Cancer Apoptosis
    Chien An Hu; Fiscal Year: 2009
    ..Deciphering functions of the novel BH3-only proteins and their interacting molecules should enhance our understanding, and potential utilization, of BH3-only proteins and lipid-mediated apoptosis in treatment of cancer. ..
  55. EMAP II Regulation of Pulmonary Cell Proliferation
    MARGARET SCHWARZ; Fiscal Year: 2007
    ..abstract_text> ..
  56. CD44-P185HER2 INTERACTION IN OVARIAN CANCER PROGRESSION
    LILLY BOURGUIGNON; Fiscal Year: 2007
    ..abstract_text> ..
  57. IL2 RECEPTOR SIGNALING IN T LYMPHOCYTES
    Steven Ziegler; Fiscal Year: 2003
    ..These studies should establish connections between IL-2 signaling and the control of cell cycle and will further understanding of the molecular regulation of T cell expansion during normal and pathological processes. ..
  58. Protein Prenyltransferases in Glucose-Stimulated Insulin Secretion
    Anjaneyulu Kowluru; Fiscal Year: 2010
    ....
  59. Southern Research Molecular Libraries Screening Center (SRMLSC)
    Gary Piazza; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  60. Aspartame Intake and the Risk of Cancer
    Eva Schernhammer; Fiscal Year: 2008
    ..Our results may help decision-makers formulate guidelines and direct future aspartame studies. Even a null finding would be important in this context. [unreadable] [unreadable] [unreadable]..
  61. International Lung Cancer Consortium: Pooled analysis o*
    Paul Brennan; Fiscal Year: 2006
    ..abstract_text> ..
  62. Markers for the Early Detection of Ovarian Cancer
    MICHAEL TAINSKY; Fiscal Year: 2007
    ..The principle is that we clone epitopes reacting with IgG in patients sera and use them to detect antibodies in sera to discriminate cancer and healthy subjects and whether we can detect disease prior to standard diagnosis. ..
  63. MECHANISMS OF METASTASIS IN EXPERIMENTAL PROSTATE CANCER
    TIMOTHY CHARLES THOMPSON; Fiscal Year: 2010
    ..abstract_text> ..
  64. MECHANISM OF INITIATION OF PROTEIN BIOSYNTHESIS
    JOHN HERSHEY; Fiscal Year: 2004
    ..The experiments will help elucidate the function and regulation of these key initiation factors. ..
  65. FOUR-CORNERS BREAST AND ENDOMETRIAL CANCER STUDY
    MARTHA OR MARTY SLATTERY; Fiscal Year: 2003
    ..C-peptide, glycosylated hemoglobin, IGF-1, and IGFBP3 will be evaluated with respect to breast and endometrial cancer in a subset of women. ..
  66. MOLECULAR CONTROL OF MAMMALIAN ENERGY HOMEOSTASIS
    STEVEN MCKNIGHT; Fiscal Year: 2001
    ....
  67. Role of ornithine decarboxylase in Ras transformation
    Lisa Shantz; Fiscal Year: 2006
    ..Keratinocytes from D1/AZ mice will also be used to analyze direct interactions of AZ with cyclin D1, to test whether other properties of AZ are important for deregulation of cell proliferation in tumor development. ..
  68. Tobacco Carcinogen Oral Cancer Model
    Joel Schwartz; Fiscal Year: 2005
    ..lc. Assessments of membrane (aryl hydrolase) and cytoplasmic phase I and II enzymes. ld. Confirmation of early cellular initiation and promotion events critical to our understanding for prevention of oral cancer. ..
  69. DIET AND SOMATIC MUTATIONS IN COLON CANCER
    MARTHA OR MARTY SLATTERY; Fiscal Year: 2007
    ..e. p53, K-ras, and microsatellite instability). Differences in colon and rectal tumors will be compared. Additionally data from rectal tumors will be combined with that from colon tumors to define disease pathways. ..
  70. APPLICATION OF NOVEL OPTICAL METHODS TO CELL DYNAMICS
    Alan Verkman; Fiscal Year: 2001
    ..These studies will address the hypothesis that the membrane skeleton of these cells is a mobile, dynamic structure. ..
  71. INHIBITION OF BREAST TUMORIGENICITY BY C MYC PO RNA
    SCOTT BLUME; Fiscal Year: 2002
    ..3. Assess the degree to which artificial manipulation of the PO 5'-untranslated sequence alters the inherent tumorigenic, invasive, and metastatic potential of human breast carcinoma xenografts in immunocompromised mice. ..
  72. PHYSIOLOGY AND MOLECULAR BIOLOGY OF LUNG WATER TRANSPORT
    Alan Verkman; Fiscal Year: 2007
    ..abstract_text> ..
  73. DIABETIC ALTERATIONS OF CARDIAC METABOLISM AND FUNCTION
    John Chatham; Fiscal Year: 2003
    ....
  74. Monoclonal Antibody Therapy for Follicular Lymphoma
    Jonathan Friedberg; Fiscal Year: 2007
    ..abstract_text> ..
  75. APPLICATION OF NOVEL OPTICAL METHODS TO CELL DYNAMICS
    Alan Verkman; Fiscal Year: 2006
    ..abstract_text> ..
  76. ENHANCING TUMOR VACCINES WITH CO-STIMULATORY MOLECULES
    Howard Kaufman; Fiscal Year: 2004
    ..This may have important implications for the future design of tumor vaccines in melanoma and other settings. ..
  77. Role of circadian system in response to cancer therapy
    MARINA ANTOCH; Fiscal Year: 2007
    ....