pulmonary surfactant associated protein b

Summary

Summary: A pulmonary surfactant associated-protein that plays an essential role in alveolar stability by lowering the surface tension at the air-liquid interface. Inherited deficiency of pulmonary surfactant-associated protein B is one cause of RESPIRATORY DISTRESS SYNDROME, NEWBORN.

Top Publications

  1. ncbi Dysfunction of pulmonary surfactant in chronically ventilated premature infants
    Jeffrey D Merrill
    Neonatology, Department of Pediatrics, University of Pennsylvania School of Medicine, USA
    Pediatr Res 56:918-26. 2004
  2. ncbi SP-B deficiency causes respiratory failure in adult mice
    Kristin R Melton
    Cincinnati Children s Hospital Medical Center, Division of Pulmonary Biology, 3333 Burnet Ave, Cincinnati, OH 45229 3039, USA
    Am J Physiol Lung Cell Mol Physiol 285:L543-9. 2003
  3. ncbi Dimeric surfactant protein B peptide sp-b(1-25) in neonatal and acute respiratory distress syndrome
    Frans J Walther
    Research and Education Institute at Harbor UCLA Medical Center, Torrance, California 90502, USA
    Exp Lung Res 28:623-40. 2002
  4. ncbi Alterations in SP-B and SP-C expression in neonatal lung disease
    Lawrence M Nogee
    Division of Neonatology, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 3200, USA
    Annu Rev Physiol 66:601-23. 2004
  5. ncbi Hydrophobic surfactant proteins in lung function and disease
    Jeffrey A Whitsett
    Division of Neonatology, Cincinnati Children s Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, OH 45229 3039, USA
    N Engl J Med 347:2141-8. 2002
  6. ncbi Transforming growth factor-beta inhibits pulmonary surfactant protein B gene transcription through SMAD3 interactions with NKX2.1 and HNF-3 transcription factors
    Changgong Li
    Department of Pediatrics, Women s and Children s Hospital, University of Southern California School of Medicine, Los Angeles, California 90033, USA
    J Biol Chem 277:38399-408. 2002
  7. ncbi Structure of mini-B, a functional fragment of surfactant protein B, in detergent micelles
    Muzaddid Sarker
    Department of Physics and Physical Oceanography, Memorial University of Newfoundland, St John s, Newfoundland, Canada
    Biochemistry 46:11047-56. 2007
  8. ncbi NMR structures of the C-terminal segment of surfactant protein B in detergent micelles and hexafluoro-2-propanol
    Valerie Booth
    Department of Biochemistry, Memorial University of Newfoundland, St John s, Newfoundland A1B 3X9, Canada valerie physics mun ca
    Biochemistry 43:15187-94. 2004
  9. ncbi Analysis of 40 sporadic or familial neonatal and pediatric cases with severe unexplained respiratory distress: relationship to SFTPB
    Mohammed Tredano
    Service de Biochimie et Biologie Moléculaire, hôpital d enfants Armand Trousseau AP HP, Paris, France
    Am J Med Genet A 119:324-39. 2003
  10. ncbi Different expression of surfactant protein B mature peptide and proprotein at 21 weeks' gestation in human fetal pulmonary epithelial cells
    Kazuhiro Mori
    Division of Neonatology, Department of Pediatrics, Keio University School of Medicine, Tokyo, Japan
    Pediatr Int 44:500-4. 2002

Detail Information

Publications164 found, 100 shown here

  1. ncbi Dysfunction of pulmonary surfactant in chronically ventilated premature infants
    Jeffrey D Merrill
    Neonatology, Department of Pediatrics, University of Pennsylvania School of Medicine, USA
    Pediatr Res 56:918-26. 2004
    ..We conclude that most premature infants requiring continued respiratory support after 7 d of age experience transient episodes of dysfunctional surfactant that are associated with a deficiency of SP-B and SP-C...
  2. ncbi SP-B deficiency causes respiratory failure in adult mice
    Kristin R Melton
    Cincinnati Children s Hospital Medical Center, Division of Pulmonary Biology, 3333 Burnet Ave, Cincinnati, OH 45229 3039, USA
    Am J Physiol Lung Cell Mol Physiol 285:L543-9. 2003
    ..Reduction of alveolar SP-B content causes surfactant dysfunction and respiratory failure, indicating that SP-B is required for postnatal lung function...
  3. ncbi Dimeric surfactant protein B peptide sp-b(1-25) in neonatal and acute respiratory distress syndrome
    Frans J Walther
    Research and Education Institute at Harbor UCLA Medical Center, Torrance, California 90502, USA
    Exp Lung Res 28:623-40. 2002
    ..The data suggest that dSP-B(1-25) is more efficient in restoring lung function in neonatal RDS and ARDS than mSP-B(1-25) surfactant...
  4. ncbi Alterations in SP-B and SP-C expression in neonatal lung disease
    Lawrence M Nogee
    Division of Neonatology, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 3200, USA
    Annu Rev Physiol 66:601-23. 2004
    ....
  5. ncbi Hydrophobic surfactant proteins in lung function and disease
    Jeffrey A Whitsett
    Division of Neonatology, Cincinnati Children s Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, OH 45229 3039, USA
    N Engl J Med 347:2141-8. 2002
  6. ncbi Transforming growth factor-beta inhibits pulmonary surfactant protein B gene transcription through SMAD3 interactions with NKX2.1 and HNF-3 transcription factors
    Changgong Li
    Department of Pediatrics, Women s and Children s Hospital, University of Southern California School of Medicine, Los Angeles, California 90033, USA
    J Biol Chem 277:38399-408. 2002
    ..1 was not affected. We conclude that SMAD3 interactions with the positive regulators NKX2.1 and HNF-3 underlie the molecular basis for TGF-beta-induced repression of Sp-B gene transcription...
  7. ncbi Structure of mini-B, a functional fragment of surfactant protein B, in detergent micelles
    Muzaddid Sarker
    Department of Physics and Physical Oceanography, Memorial University of Newfoundland, St John s, Newfoundland, Canada
    Biochemistry 46:11047-56. 2007
    ..Interhelix interactions are stabilized by both disulfide bonds and by interleaving of hydrophobic side chains from the two helices...
  8. ncbi NMR structures of the C-terminal segment of surfactant protein B in detergent micelles and hexafluoro-2-propanol
    Valerie Booth
    Department of Biochemistry, Memorial University of Newfoundland, St John s, Newfoundland A1B 3X9, Canada valerie physics mun ca
    Biochemistry 43:15187-94. 2004
    ....
  9. ncbi Analysis of 40 sporadic or familial neonatal and pediatric cases with severe unexplained respiratory distress: relationship to SFTPB
    Mohammed Tredano
    Service de Biochimie et Biologie Moléculaire, hôpital d enfants Armand Trousseau AP HP, Paris, France
    Am J Med Genet A 119:324-39. 2003
    ..When disease loci are identified, patient genotyping will be crucial as a diagnostic aid, for devising proper treatment, and as a basis for genetic counseling...
  10. ncbi Different expression of surfactant protein B mature peptide and proprotein at 21 weeks' gestation in human fetal pulmonary epithelial cells
    Kazuhiro Mori
    Division of Neonatology, Department of Pediatrics, Keio University School of Medicine, Tokyo, Japan
    Pediatr Int 44:500-4. 2002
    ..The aim of this study is to evaluate the maturation of pulmonary epithelial cells in human fetal lungs at 21 weeks' gestation...
  11. ncbi Involvement of napsin A in the C- and N-terminal processing of surfactant protein B in type-II pneumocytes of the human lung
    Frank Brasch
    Department of Anatomy, University of Gottingen, Kreuzbergring 36, D 37075 Gottingen, Germany
    J Biol Chem 278:49006-14. 2003
    ..Two of the four processing products generated in vitro were also detected in type-II pneumocytes. In conclusion, our results show that napsin A is involved in the N- and C-terminal processing of proSP-B in type-II pneumocytes...
  12. ncbi Genetic variant characterization in intron 4 of the surfactant protein B gene
    Aaron Hamvas
    Division of Newborn Medicine, Edward Mallinckrodt Department of Pediatrics, Washington University School of Medicine and St Louis Children s Hospital, St Louis, Missouri, USA
    Hum Mutat 26:494-5. 2005
    ..7, 95% CI 1.0-7.2). Reliable characterization of genetic variants in intron 4 requires both a high fidelity polymerase and sequencing of variant alleles...
  13. pmc Differences in N-linked glycosylation between human surfactant protein-B variants of the C or T allele at the single-nucleotide polymorphism at position 1580: implications for disease
    Guirong Wang
    Department of Cellular and Molecular Physiology, The Pennsylvania State University, College of Medicine, Hershey, PA 17033, USA
    Biochem J 369:179-84. 2003
    ..Further, we speculate that, given the fact that this SNP is found frequently in the general population, N-linked glycosylation at residue Asn129 interferes with SP-B processing, secretion and folding under certain disease conditions...
  14. pmc Comprehensive genetic variant discovery in the surfactant protein B gene
    Aaron Hamvas
    Edward Mallinckrodt Department of Pediatrics, Washington University School of Medicine and St Louis Children s Hospital, St Louis, Missouri 63110, USA
    Pediatr Res 62:170-5. 2007
    ....
  15. pmc Critical structure-function determinants within the N-terminal region of pulmonary surfactant protein SP-B
    Alicia G Serrano
    Departamento de Bioquimica y Biologia Molecular I, Facultad de Biologia, Universidad Complutense, Madrid, Spain
    Biophys J 90:238-49. 2006
    ....
  16. ncbi Cysteine protease activity is required for surfactant protein B processing and lamellar body genesis
    Susan Guttentag
    Division of Neonatology, Department of Pediatrics, University of Pennsylvania School of Medicine, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104 4318, USA
    Am J Respir Cell Mol Biol 28:69-79. 2003
    ..Our data show that a cysteine protease is involved in SP-B processing, lamellar body genesis, and SP-C processing, and suggest that Cathepsin H is the most likely candidate protease...
  17. ncbi Topographical organization of the N-terminal segment of lung pulmonary surfactant protein B (SP-B(1-25)) in phospholipid bilayers
    Yudong Wang
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
    Biochemistry 42:4015-27. 2003
    ....
  18. ncbi Mapping and analysis of the lytic and fusogenic domains of surfactant protein B
    Marnie A Ryan
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
    Biochemistry 44:861-72. 2005
    ....
  19. ncbi Protein-lipid interactions and surface activity in the pulmonary surfactant system
    Alicia G Serrano
    Departamento de Bioquimica y Biologia Molecular I, Facultad de Biologia, Universidad Complutense, Jose Antonio Novais 2, Madrid, Spain
    Chem Phys Lipids 141:105-18. 2006
    ..The understanding of the mechanisms of action of these proteins is critical to approach the design and development of new clinical surfactant preparations for therapeutical applications...
  20. ncbi Antimicrobial activity of native and synthetic surfactant protein B peptides
    Marnie A Ryan
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, and University of Cincinnati College of Medicine, OH 45229 3039, USA
    J Immunol 176:416-25. 2006
    ..These results suggest that the role of endogenous SP-B in host defense may be limited; however, synthetic peptides derived from SP-B may be useful in the treatment of bacterial pneumonias...
  21. pmc Molecular dynamics simulations of the anchoring and tilting of the lung-surfactant peptide SP-B1-25 in palmitic acid monolayers
    Hwankyu Lee
    Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan 48109, USA
    Biophys J 89:3807-21. 2005
    ..Our work indicates that the factors controlling orientation of small peptides in lipid layers can now be uncovered through molecular dynamics simulations...
  22. ncbi Simple, helical peptoid analogs of lung surfactant protein B
    Shannon L Seurynck
    Department of Chemical and Biological Engineering, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208, USA
    Chem Biol 12:77-88. 2005
    ..The extent of biomimicry appears to correlate with peptoid helicity and lipophilicity. These biostable oligomers could serve in a synthetic surfactant replacement to treat respiratory distress syndrome...
  23. ncbi Surface properties of sulfur- and ether-linked phosphonolipids with and without purified hydrophobic lung surfactant proteins
    Yusuo Chang
    Department of Pediatrics, University of Rochester, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Chem Phys Lipids 137:77-93. 2005
    ..The high activity and inhibition resistance of synthetic surfactants containing DEPN-8 or SO(2)-lipid plus SP-B/SP-C are promising for future applications in treating surfactant dysfunction in inflammatory lung injury...
  24. pmc Molecular dynamics simulations of a pulmonary surfactant protein B peptide in a lipid monolayer
    J Alfredo Freites
    Department of Physics and Astronomy and Institute for Surface and Interface Science, University of California, Irvine, California 92697 4575, USA
    Biophys J 84:2169-80. 2003
    ....
  25. ncbi Protein- and lipid modification of natural bovine surfactant. Effects in experimental lung failure with special consideration of the response in neonates
    Ludwig Gortner
    Department of Pediatrics and Neonatology, University of the Saarland, Homburg Saar Germany
    Arzneimittelforschung 56:25-32. 2006
    ..The aim of the present study therefore was to compare the effects of a lipid-enriched and protein-modified natural surfactant preparations with a licensed, clinically used bovine surfactant preparation - SF-Ril (Alveofact)...
  26. pmc Expression profiles of hydrophobic surfactant proteins in children with diffuse chronic lung disease
    Matthias Griese
    Kinderklinik and Poliklinik, Dr von Haunersches Kinderspital, Ludwig Maximilians University, Munich, Germany
    Respir Res 6:80. 2005
    ..The profile of these proteins in the alveolar space is unknown in such subjects...
  27. ncbi Structure and conformation of the disulfide bond in dimeric lung surfactant peptides SP-B1-25 and SP-B8-25
    Nilanjana Biswas
    Department of Chemistry, University of Georgia, Athens, GA 30602 2556, USA
    Biochim Biophys Acta 1768:1070-82. 2007
    ....
  28. ncbi Surfactant protein A and B genetic variants in respiratory distress syndrome in singletons and twins
    Riitta Marttila
    Seinajoki Central Hospital, Seinajoki, Finland
    Am J Respir Crit Care Med 168:1216-22. 2003
    ..Genetic and environmental variation may influence intracellular processing of surfactant complex and the susceptibility to RDS...
  29. ncbi Partial SP-B deficiency perturbs lung function and causes air space abnormalities
    Lori L Nesslein
    Cincinnati Children s Hospital Medical Center, Division of Neonatology, 3333 Burnet Ave, Cincinnati, OH 45229 3039, USA
    Am J Physiol Lung Cell Mol Physiol 288:L1154-61. 2005
    ..Chronic, nonuniform SP-B deficiency perturbed pulmonary function and caused air space enlargement...
  30. ncbi Surfactant protein B in type II pneumocytes and intra-alveolar surfactant forms of human lungs
    Frank Brasch
    Department of Anatomy, University of Gottingen, Gottingen, Germany
    Am J Respir Cell Mol Biol 30:449-58. 2004
    ..In human lungs, mature SP-B is involved in the structural organization of lamellar bodies and tubular myelin by the formation of core particles...
  31. ncbi Comparison of three lipid formulations for synthetic surfactant with a surfactant protein B analog
    Frans J Walther
    Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, California 90502, USA
    Exp Lung Res 31:563-79. 2005
    ..Lipid composition plays a crucial role in the in vitro and in vivo functions of SP-B(1-25) in surfactant preparations...
  32. ncbi The TTF-1/TAP26 complex differentially modulates surfactant protein-B (SP-B) and -C (SP-C) promoters in lung cells
    Meng Chun Yang
    Department of Internal Medicine, Pulmonary and Critical Care Medicine, UT Southwestern Medical Center, Dallas, TX 75390 9034, USA
    Biochem Biophys Res Commun 344:484-90. 2006
    ..Thus, a dimerized complex structure was needed for advanced promoter activity. This result also provided a molecular mechanism by which both the SP-B and SP-C promoters could be differentially regulated by the same complex...
  33. ncbi Effects of including an N-terminal insertion region and arginine-mimetic side chains in helical peptoid analogues of lung surfactant protein B
    Shannon L Seurynck-Servoss
    Department of Chemical and Biological Engineering, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208, USA
    Biochemistry 45:11809-18. 2006
    ....
  34. ncbi Hydrophobic surfactant proteins and their analogues
    Frans J Walther
    Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA, USA
    Neonatology 91:303-10. 2007
    ..These synthetic surfactant preparations may also be a cost-saving therapeutic approach, with better quality control than may be obtained with animal-based treatments...
  35. pmc Surfactant protein B intron 4 variation in German patients with COPD and acute respiratory failure
    Carola Seifart
    Department of Internal Medicine, Division Respiratory and Critical Care Medicine, Philipps University of Marburg, Baldingerstasse, 35043 Marburg, Germany
    Dis Markers 18:129-36. 2002
    ..5%, p = 0.003, OR 4.9, 95% CI: 1.76-13.6). The data indicate that SP-B intron 4 variants may associate with increased risk of ARF in COPD and may be used as a marker of susceptibility in this disease subgroup...
  36. ncbi Processing of pulmonary surfactant protein B by napsin and cathepsin H
    Takayuki Ueno
    Cancer Center Karolinska, Department of Oncology Pathology, Karolinska Institute and Hospital, SE 171 76 Stockholm, Sweden
    J Biol Chem 279:16178-84. 2004
    ..These results suggest that napsin, cathepsin H, and at least one other enzyme are involved in maturation of the biologically active SP-B peptide...
  37. ncbi Surfactant protein B: structure and function
    Sam Hawgood
    Department of Pediatrics and Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA 94118 1245, USA
    Biol Neonate 85:285-9. 2004
    ..This review will focus on just one of the apoproteins, surfactant protein B, with a description of protein structure and the actions of surfactant protein B on surfactant lipid membranes...
  38. ncbi Surfactant with SP-B and SP-C analogues improves lung function in surfactant-deficient rats
    Frans J Walther
    Harbor University of California Los Angeles Research and Education Institute, Torrance, Calif 90502, USA
    Biol Neonate 82:181-7. 2002
    ....
  39. pmc Molecular dynamics study of the lung surfactant peptide SP-B1-25 with DPPC monolayers: insights into interactions and peptide position and orientation
    Senthil K Kandasamy
    Chemical Engineering Department, The University of Michigan, Ann Arbor, MI 48109, USA
    Biophys J 88:1577-92. 2005
    ..The first eight amino acids of the peptide, also known as the insertion sequence, are found to be essential in reducing the fluctuations and anchoring the peptide in the lipid/water interface...
  40. ncbi N-terminally extended surfactant protein (SP) C isolated from SP-B-deficient children has reduced surface activity and inhibited lipopolysaccharide binding
    Jing Li
    Department of Medical Biochemistry and Biophysics, Karolinska Institutet, S 171 77 Stockholm, Sweden
    Biochemistry 43:3891-8. 2004
    ..The results of this study indicate that the early postnatal fatal respiratory distress seen in SP-B-deficient children is combined with the near absence of active variants of SP-C...
  41. ncbi Genetic mechanisms of surfactant deficiency
    Lawrence M Nogee
    Department of Pediatrics, Division of Neonatology, Johns Hopkins University School of Medicine, Baltimore, MD 21287 3200, USA
    Biol Neonate 85:314-8. 2004
    ..The clinical and laboratory features associated with these genetic disorders, along with their implications for the understanding of normal surfactant metabolism, are reviewed...
  42. ncbi Polymorphisms of surfactant protein B encoding gene: modifiers of the course of neonatal respiratory distress syndrome?
    Vassiliki Makri
    Department of Paediatrics and Neonatology, University Children s Hospital, Justus Liebig University, Feulgenstrasse 12, 35392 Giessen, Germany
    Eur J Pediatr 161:604-8. 2002
    ..05) and the need for surfactant administration were also higher in group 2 than in group 1 (43.2% versus 72.4%, P < 0.01). Duration of mechanical ventilation and rate of chronic lung disease at 36 weeks were comparable in both groups...
  43. ncbi Regulation of human pulmonary surfactant protein gene expression by 1alpha,25-dihydroxyvitamin D3
    Sarabjit S Phokela
    Dept of Pediatrics, The University of Texas Health Science Center, Houston, TX 77030, USA
    Am J Physiol Lung Cell Mol Physiol 289:L617-26. 2005
    ....
  44. ncbi Prenatal exposure to thyroid hormone is necessary for normal postnatal development of murine heart and lungs
    Minke van Tuyl
    Department of Pediatric Surgery, Sophia Children s Hospital, Erasmus Medical Center, Rotterdam, The Netherlands
    Dev Biol 272:104-17. 2004
    ..Our study shows that these effects of maternal hypothyroidism become manifest after birth and are aggravated by the concomitant existence of neonatal hypothyroidism...
  45. ncbi Positive end-expiratory pressure modifies response to recombinant and natural exogenous surfactant in ventilated immature newborn rabbits
    Anne Hilgendorff
    Department of Pediatrics and Neonatology, Justus Liebig University Giessen, Giessen, Germany
    Biol Neonate 90:210-6. 2006
    ..Therefore, the effects of a recombinant surfactant protein C (rSP-C) based preparation and a natural surfactant were compared applying different levels of positive end-expiratory pressure (PEEP) in experimental RDS...
  46. ncbi Effects of hyaluronan-fortified surfactant in ventilated premature piglets with respiratory distress
    Xiaoning Wang
    Laboratory of Pediatric Respiratory and Intensive Care Medicine, Children s Hospital of Fudan University, Shanghai, PR China
    Biol Neonate 89:15-24. 2006
    ..We conclude that HA added to 50 mg/kg Curosurf or use of 100 mg/kg Curosurf with or without HA provides the best effects in terms of lung function and reduction of inflammation...
  47. ncbi Effects of vascular endothelial growth factor on isolated fetal alveolar type II cells
    William Raoul
    Institut National de la Santé et de la Recherche Médicale Unité U492, Faculte de Medecine, Universite Paris XII, 8 rue du General Sarrail, 94010 Creteil, France
    Am J Physiol Lung Cell Mol Physiol 286:L1293-301. 2004
    ....
  48. ncbi Inherited disorders of neonatal lung diseases
    Murat Yurdakok
    Department of Pediatrics, Hacettepe University, Faculty of Medicine, Ankara, Turkey
    Turk J Pediatr 46:105-14. 2004
    ..No human infant or child with respiratory distress and mutation in the surfactant protein D gene has been identified...
  49. ncbi Lung specific developmental expression of the Xenopus laevis surfactant protein C and B genes
    Brian A Hyatt
    Bethel University, St Paul, MN 55112, USA
    Gene Expr Patterns 7:8-14. 2007
    ..laevis, xSP-C and xSP-B are expressed only in lung. Knowledge of the sequence and expression pattern of these two surfactant proteins in Xenopus might allow for use of this organism to study early lung development...
  50. ncbi Diminished lung compliance and elevated surfactant lipids and proteins in nutritionally obese young rats
    L S Inselman
    Department of Pediatrics, Division of Pulmonology, Alfred I duPont Hospital for Children, 1600 Rockland Road, Wilmington, Delaware 19899, USA
    Lung 182:101-17. 2004
    ..We speculate that intrapulmonary lipid deposition and possible surfactant deficiency relative to alveolar surface area may contribute to the reduction in lung compliance in obese rats...
  51. ncbi Distribution of surfactant proteins in type II pneumocytes of newborn, 14-day old, and adult rats: an immunoelectron microscopic and stereological study
    Andreas Schmiedl
    Centre of Anatomy, Hannover School of Medicine, Carl Neuberg Strasse 1, 30625, Hannover, Germany
    Histochem Cell Biol 124:465-76. 2005
    ..The postnatal compartment-specific distribution of SP-A, precursors of SP-C and SP-D does not change...
  52. ncbi Unexplained neonatal respiratory distress due to congenital surfactant deficiency
    Marco Somaschini
    Division of Neonatology, Bolognini Hospital, Seriate, Italy
    J Pediatr 150:649-53, 653.e1. 2007
    ..Deficiency of adenosine triphosphate-binding cassette protein, member A3 (n = 12) was a more frequent cause of this phenotype than deficiency of surfactant protein B (n = 2)...
  53. ncbi Pulmonary pathology
    Daphne E Demello
    Department of Pathology, St Louis University Health Sciences Center and Cardinal Glennon Children s Hospital, St Louis, MO 63104, USA
    Semin Neonatol 9:311-29. 2004
    ..There is also a critical need for establishing an archival tissue bank to permit future molecular biological studies...
  54. ncbi [Comparison of the effect of ambroxol and dexamethasone on the expression of pulmonary surfactant proteins in the fetal rat lungs]
    Xue ming Fu
    Department of Neonatology, Children s Hospital, Chongqing Medical University, Chongqing 400014, China
    Zhonghua Er Ke Za Zhi 42:450-3. 2004
    ..To investigate the effects of maternally administered dexamethasone and ambroxol on the mRNA levels of surfactant proteins (SP-A, SP-B and SP-C) expression in fetal rat lungs at gestational age day 19...
  55. ncbi Interfacial properties of pulmonary surfactant layers
    R Wüstneck
    Charite, Campus Virchow Klinikum, Universitatsmedizin Berlin, Klinik fur Anasthesiologie und Operative Intensivmedizin, Spandauer Damm 130, 14050 Berlin, Germany
    Adv Colloid Interface Sci 117:33-58. 2005
    ..An outlook summarizes the present knowledge and the main future development in this field of surface science...
  56. pmc Defective surfactant secretion in a mouse model of Hermansky-Pudlak syndrome
    Susan H Guttentag
    Division of Neonatology, Department of Pediatrics, Children s Hospital of Philadelphia, 19104 4318, USA
    Am J Respir Cell Mol Biol 33:14-21. 2005
    ..Together, our data indicate that GLB formation is not associated with abnormal trafficking or recycling of surfactant material. Instead, impaired secretion is an important component of GLB formation in ep/pe mice...
  57. ncbi The development of the pulmonary surfactant system in California sea lions
    Natalie J Miller
    Environmental Biology, School of Earth and Environmental Sciences, Darling Building, University of Adelaide, North Tce, Australia
    Comp Biochem Physiol A Mol Integr Physiol 141:191-9. 2005
    ..The onset of diving is probably a trigger for surfactant development in these animals...
  58. pmc Reactive oxygen species inactivation of surfactant involves structural and functional alterations to surfactant proteins SP-B and SP-C
    Karina Rodriguez-Capote
    Department of Obstetrics Gynaecology, Canadian Institutes of Health Research Group in Fetal and Neonatal Health and Development, University of Western Ontario, London, Ontario, Canada
    Biophys J 90:2808-21. 2006
    ....
  59. pmc Surfactant replacement and open lung concept--comparison of two treatment strategies in an experimental model of neonatal ARDS
    Anne Hilgendorff
    Dept of Pediatrics and Neonatology, University of Giessen and Marburg, Germany
    BMC Pulm Med 8:10. 2008
    ....
  60. pmc Multilayer structures in lipid monolayer films containing surfactant protein C: effects of cholesterol and POPE
    Stefan Malcharek
    Institut fur Biochemie, Westfalische Wilhelms Universitat Munster, D 48149 Munster, Germany
    Biophys J 88:2638-49. 2005
    ..In contrast, POPE, as a nonbilayer lipid thought to stabilize the edges of protrusions, leads to more narrow protrusions. The lateral extension of the protrusions is thereby more influenced than their height...
  61. ncbi Surfactant proteins B and C are both necessary for alveolar stability at end expiration in premature rabbits with respiratory distress syndrome
    Andreas Almlén
    Dept of Molecular Medicine and Surgery, Section of Clinical Chemistry, Bldg L2 03, Karolinska Univ Hospital, SE 171 76 Stockholm, Sweden
    J Appl Physiol (1985) 104:1101-8. 2008
    ....
  62. ncbi New synthetic surfactants: the next generation?
    Robert H Pfister
    Department of Pediatrics, University of Vermont College of Medicine, Burlington, VT, USA
    Biol Neonate 87:338-44. 2005
    ..Clinicians will need to further understand any differences in clinical effects between available products...
  63. ncbi The influence of gestation and mechanical ventilation on serum clara cell secretory protein (CC10) concentrations in ventilated and nonventilated newborn infants
    Alison Loughran-Fowlds
    Department of Newborn Care, Royal Hospital for Women, Randwick, NSW, Australia
    Pediatr Res 60:103-8. 2006
    ..This surge is more pronounced in term infants and may confer them with superior extrauterine pulmonary protection compared with preterm infants...
  64. ncbi Exogenous surfactant replacement in ARDS--one day, someday, or never?
    Simon V Baudouin
    University Department of Surgical Sciences and the Department of Anaesthesia, Royal Victoria Infirmary, Newcastle upon Tyne, United Kingdom
    N Engl J Med 351:853-5. 2004
  65. ncbi Oxidative stress in fetal lambs exposed to intra-amniotic endotoxin in a chorioamnionitis model
    Fook Choe Cheah
    Department of Neonatology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Pediatr Res 63:274-9. 2008
    ..Surfactant protein A and B mRNAs were highest at 2 d, suggesting that oxidative stress did not contribute to the lung maturation response. A modest lung oxidative stress in chorioamnionitis could contribute to bronchopulmonary dysplasia...
  66. ncbi Inhibition of nitric oxide restores surfactant gene expression following nickel-induced acute lung injury
    Susan A McDowell
    University of Cincinnati, and Children s Hospital Medical Center, Cincinnati, OH 45267 0056, USA
    Am J Respir Cell Mol Biol 28:188-98. 2003
    ..Rather, systemic L-NAME treatment appears to attenuate pulmonary endothelial NOS activity, subsequent cytokine expression, inflammation, and protein permeability, and thereby restores surfactant gene expression and increases survival...
  67. ncbi Evolution of the lung surfactant proteins in birds and mammals
    Austin L Hughes
    Department of Biological Sciences, University of South Carolina, Coker Life Sciences Bldg, 700 Sumter St, Columbia, SC 29208, USA
    Immunogenetics 59:565-72. 2007
    ..Further, they imply that the loss of surfactant protein genes in the avian lineages formed part of major genomic rearrangement events that involved the loss of other genes as well...
  68. ncbi The importance of surfactant on the development of neonatal pulmonary diseases
    Priscila Pinheiro Ribeiro Lyra
    Department of Neonatology, Hospital das Clinicas, Medical School, São Paulo UniversitySão Paulo, SP, Brazil
    Clinics (Sao Paulo) 62:181-90. 2007
    ....
  69. ncbi Changes in alveolar epithelial cell proportions during fetal and postnatal development in sheep
    S J Flecknoe
    Dept of Physiology, Monash Univ P O Box 13F, Victoria 3800, Australia
    Am J Physiol Lung Cell Mol Physiol 285:L664-70. 2003
    ..Thus before birth type I AECs predominate, whereas after birth type II AECs predominate, possibly due to the reduction in basal lung expansion associated with the entry of air into the lungs...
  70. ncbi Fibrinolysis-inhibitory capacity of clot-embedded surfactant is enhanced by SP-B and SP-C
    Philipp Markart
    Department of Internal Medicine, Justus Liebig University Giessen, Klinikstrasse 36, D 35385 Giessen, Germany
    Am J Physiol Lung Cell Mol Physiol 284:L69-76. 2003
    ..In the case of SP-B, increased phospholipid incorporation may underlie this finding...
  71. ncbi Inhaled nitric oxide increases surfactant protein gene expression in the intact lamb
    Regan B Stuart
    Dept of Pediatrics, Univ of California, San Francisco, 505 Parnassus M680, Box 0106, San Francisco, California 94143 0106, USA
    Am J Physiol Lung Cell Mol Physiol 285:L628-33. 2003
    ..DNA content was unchanged. The mechanisms and physiological effects of these findings warrant further investigation...
  72. ncbi Effects of maternal retinoic acid administration in a congenital diaphragmatic hernia rabbit model
    Denis Gallot
    Universite d Auvergne, JE2447 ARDEMO, F 63000, Clermont Ferrand, France
    Pediatr Pulmonol 43:594-603. 2008
    ..However, ATRA lowers surfactant protein expression and normalizes type I/II pneumocyte ratio to what is observed in normal lungs...
  73. ncbi Dexamethasone potentiates keratinocyte growth factor-stimulated SP-A and SP-B gene expression in alveolar epithelial cells
    O Banine Mouhieddine-Gueddiche
    INSERM U492, Physiopathologie et Thérapeutique Respiratoires, Universite Paris XII, Creteil, France
    Pediatr Res 53:231-9. 2003
    ..For the latter, increased mRNA stability was evidenced with the aid of actinomycin D. The Dex-KGF synergy may have potential interest for diseases associated with surfactant deficiency...
  74. ncbi Bronchoalveolar lavage surfactant protein a, B, and d concentrations in preterm infants ventilated for respiratory distress syndrome receiving natural and synthetic surfactants
    Michael W Beresford
    Neonatal Unit, Liverpool Women s Hospital, UK
    Pediatr Res 53:663-70. 2003
    ..BAL SP-A and SP-D concentrations did not differ significantly between infants randomized to receive a natural or synthetic surfactant. Lower BAL SP-B and SP-D but not SP-A concentrations were associated with worse clinical prognosis...
  75. ncbi Continuous mechanical contraction modulates expression of alveolar epithelial cell phenotype
    Jorge A Gutierrez
    Department of Pediatrics, University of California, San Francisco, CA 94118, USA
    Am J Respir Cell Mol Biol 29:81-7. 2003
    ..In summary, mechanical contraction favors expression of the type II cell phenotype and inhibits expression of the type I cell phenotype in a time- and amplitude-dependent manner...
  76. ncbi Loss of murine Na+/myo-inositol cotransporter leads to brain myo-inositol depletion and central apnea
    Gerard T Berry
    Department of Pediatrics, University of Pennsylvania School of Medicine, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 278:18297-302. 2003
    ..This model demonstrates the critical importance of SMIT1 in the developing nervous system. The high affinity SMIT1 transporter is responsible for the Ins concentration gradient in the murine fetal-placental unit...
  77. pmc Activity and inhibition resistance of a phospholipase-resistant synthetic surfactant in rat lungs
    Zhengdong Wang
    Department of Pediatrics, Box 850 MRBX, University of Rochester School of Medicine, Rochester, NY 14642, USA
    Am J Respir Cell Mol Biol 37:387-94. 2007
    ....
  78. ncbi Changes in biochemical and biophysical surfactant properties with cardiopulmonary bypass in children
    Bernd Friedrich
    Department of Pediatrics, Justus Leibig University, Giessen, Germany
    Crit Care Med 31:284-90. 2003
    ..The aim of the present study was to characterize pulmonary surfactant properties in children undergoing cardiovascular surgery with cardiopulmonary bypass...
  79. ncbi Expression of surfactant proteins and thyroid transcription factor 1 in an ovine model of congenital diaphragmatic hernia
    Alexandra Benachi
    Maternité Hospitalo Universitaire Necker Enfants Malades, Paris, France
    J Pediatr Surg 37:1393-8. 2002
    ....
  80. pmc Genetic variants of surfactant proteins A, B, C, and D in bronchopulmonary dysplasia
    J Pavlovic
    Department of Cellular and Molecular Physiology, PSU, Hershey, PA 17033, USA
    Dis Markers 22:277-91. 2006
    ..The data indicate that SP loci are linked to BPD. Studies in different study groups and/or of larger sample size are warranted to confirm these observations and delineate genetic background of BPD subgroups...
  81. ncbi Pulmonary surfactant protein A, B, and C mRNA and protein expression in the nitrofen-induced congenital diaphragmatic hernia rat model
    Minke van Tuyl
    Department of Surgery, Sophia Children s Hospital, Erasmus Medical Center Rotterdam, 3015 GJ Rotterdam, The Netherlands
    Pediatr Res 54:641-52. 2003
    ..No differences in the mean OD or % Area for the SP mRNAs were found between the ipsi- and contralateral side of CDH lungs. We conclude that there is no primary deficiency of surfactant proteins in the nitrofen-induced CDH rat model...
  82. ncbi Mechanical ventilation down-regulates surfactant protein A and keratinocyte growth factor expression in premature rabbits
    Robert J Digeronimo
    Department of Pediatrics, Wilford USAF Hall Medical Center, Lackland AFB, Texas 78236 5300, USA
    Pediatr Res 62:277-82. 2007
    ..These data suggest that MV alters surfactant-associated protein and growth factor expression, which may contribute to injury in the developing lung...
  83. ncbi Expression and localization of surfactant proteins in human nasal epithelium
    Jin Kook Kim
    Dept of Otorhinolaryngology Head and Neck Sugery, Konkuk University College of Medicine, Seoul
    Am J Physiol Lung Cell Mol Physiol 292:L879-84. 2007
    ..We demonstrate that SP-A, SP-B, and SP-D are expressed in human nasal mucosa and cultured NHNE cells. Further study of the functional role of SPs in the upper airway is required...
  84. ncbi [Regulation of epidermal growth factor, thyrotropin releasing hormone and dexamethasone on the expression of fetal lung SP mRNAs in rabbits]
    Feng Ying Wang
    Department of Obstetrics and Gynecology, Southwestern Hospital, Third Military Medical University, Chongqing 400038, China
    Zhonghua Fu Chan Ke Za Zhi 38:541-4. 2003
    ..To compare the effect of epidermal growth factor (EGF), thyrotropin releasing hormone (TRH) and dexamethasone (Dex) on the expression of surfactant protein (SP)-A, SP-B and SP-C mRNA in fetal rabbit lungs...
  85. ncbi Increased pulmonary blood flow does not alter surfactant protein gene expression in lambs within the first week of life
    Jae W Lee
    Department of Anesthesiology, University of California, CA 94143, USA
    Am J Physiol Lung Cell Mol Physiol 286:L1237-43. 2004
    ....
  86. ncbi Foetal rat lung epithelial (FRLE) cells: partial characterisation and response to pneumotoxins
    K Ridd
    School of Biomolecular Sciences, Liverpool John Moores University, Liverpool L3 3AF, UK
    Toxicol In Vitro 18:79-88. 2004
    ..Thus, FRLE cells appear to be a good in vitro model for monitoring the potential toxicity to ATII cells and could be used as an initial screen for pneumotoxicity...
  87. ncbi Inflammatory and anti-inflammatory responsiveness of surfactant proteins in fetal and neonatal rabbit lung
    Outi Vayrynen
    Department of Pediatrics and Biocenter Oulu, University of Oulu, Kajaanintie 52, 90220 Oulu, Finland
    Pediatr Res 55:55-60. 2004
    ..They may explain some of the acute beneficial effects of glucocorticoid therapy in chorioamnionitis before premature birth and in inflammatory lung disease after birth...
  88. ncbi Multilayers at the surface of solutions of exogenous lung surfactant: direct observation by neutron reflection
    D Follows
    Physical and Theoretical Chemistry Laboratory, South Parks Road, Oxford, OX1 3QZ, UK
    Biochim Biophys Acta 1768:228-35. 2007
    ....
  89. ncbi Surfactant protein A and B genetic variants predispose to idiopathic pulmonary fibrosis
    Moises Selman
    Instituto Nacional de Enfermedades Respiratorias, Mexico DF, Mexico
    Hum Genet 113:542-50. 2003
    ..These findings indicate that surfactant protein variants may serve as markers to identify subgroups of patients at risk, and we speculate that these contribute to IPF pathogenesis...
  90. ncbi Surfactant phospholipids and proteins are increased in fetal sheep with pulmonary hypertension secondary to fetal systemic arteriovenous fistula
    Alexandra Benachi
    Institut National de la Santè et de la Recherche Mèdicale U492, Faculte de Medicine, Creteil, France
    Am J Physiol Lung Cell Mol Physiol 288:L562-8. 2005
    ..Whether similar changes in surfactant are encountered in human neonates with persistent pulmonary hypertension is worthy of investigation...
  91. ncbi Surfactant protein expression in human skin: evidence and implications
    Young Keun Mo
    Therapeutics Research Unit, School of Medicine, University of Queensland, Princess Alexandra Hospital, Queensland, Australia
    J Invest Dermatol 127:381-6. 2007
    ..The possible roles of SPs in skin, based on their known functions in the lung are discussed. However, their potential as therapeutic targets or diagnostic markers of skin disease remains to be elucidated...
  92. ncbi Activation of surfactant protein-B transcription: signaling through the SP-A receptor utilizing the PI3 kinase pathway
    D S Strayer
    Department of Pathology and Cell Biology, Jefferson Medical College, Philadelphia, PA 19107, USA
    J Cell Physiol 184:229-38. 2000
    ..SP-A activation of this signaling pathway, which affects many cellular functions and has not previously been implicated in type II cell transcriptional activity, has profound import for understanding type II cell biology...
  93. ncbi Single nucleotide polymorphism in 5'-flanking region reduces transcription of surfactant protein B gene in H441 cells
    Klaus H Thomas
    Department of Internal Medicine Infectious Diseases and Respiratory Medicine, Charite Universitatsmedizin Berlin, Campus Mitte, Germany
    Am J Physiol Lung Cell Mol Physiol 291:L386-90. 2006
    ..We conclude that the described SNP causes differences in SP-B transcriptional activity and thus may contribute to individually different SP-B mRNA levels...
  94. ncbi Identification of genes differentially expressed in normal lung and non-small cell lung carcinoma tissue
    P Schraml
    Kantonsspital Basel, Zentrum fur Lehre und Forschung, Switzerland
    Cancer Res 54:5236-40. 1994
    ..One cDNA clone is identical to a recently described human expressed sequence tag whose gene is still unknown...
  95. ncbi Successful treatment of congenital pulmonary alveolar proteinosis with intravenous immunoglobulin G administration
    Kazutoshi Cho
    Maternity and Perinatal Care Center, Hokkaido University Hospital, Hokkaido, Sapporo, Japan
    Respirology 11:S74-7. 2006
    ..In a flow cytometric study, IgM was expressed on the cell surface. In conclusion, an abnormality in a single gene may have decreased secretion of immunoglobulin from the B cells and the AM phagocytotic activity in the patient...
  96. ncbi Isolation and characterization of the cDNA for pulmonary surfactant-associated protein-B (SP-B) in the rabbit
    J J Xu
    Department of Obstetrics and Gynaecology, University of Western Ontario, London, Canada
    Biochem Biophys Res Commun 160:325-32. 1989
    ..These proteins were immunoprecipitated by an antibody raised against bovine SP-B. Northern blot analysis revealed the mRNA for rabbit SP-B appears in fetal rabbit lung late in gestation and falls slightly in the neonate...
  97. ncbi Synthesis, secondary structure and folding of the bend region of lung surfactant protein B
    A J Waring
    Drew University King Medical Center Department of Pediatrics, Los Angeles, CA 90059, USA
    Pept Res 9:28-39. 1996
    ..Based on these observations with peptide analogs, residues 35 to 46 probably form a similar bend in the full-length protein...
  98. pmc Dynamic surface activity of a fully synthetic phospholipase-resistant lipid/peptide lung surfactant
    Frans J Walther
    Los Angeles Biomedical Research Institute, Harbor University of California at Los Angeles Medical Center, Torrance, California, United States of America
    PLoS ONE 2:e1039. 2007
    ..Calf lung surfactant extract (CLSE) was used as a positive control...
  99. ncbi Impaired alveolar epithelial cell differentiation in the hypoplastic lung in nitrofen-induced congenital diaphragmatic hernia
    Hajime Takayasu
    Children s Research Centre, Our Lady s Hospital for Sick Children, University College Dublin, Dublin 12, Ireland
    Pediatr Surg Int 23:405-10. 2007
    ..This data provides the first evidence to support the hypothesis that AEC differentiation is impaired in CDH hypoplastic lung...
  100. pmc Human pulmonary alveolar proteinosis associated with a defect in GM-CSF/IL-3/IL-5 receptor common beta chain expression
    U Dirksen
    Department of Pediatrics, Children s Hospital Medical Center, Heinrich Heine University, Dusseldorf, Germany
    J Clin Invest 100:2211-7. 1997
    ..Analysis of beta c DNA revealed a point mutation from proline to threonine at codon 602 in one patient. Our findings provide evidence that a defect in the expression of a hematopoietic cytokine receptor is associated with human PAP...
  101. ncbi Expression and localization of lung surfactant protein B in Eustachian tube epithelium
    R Paananen
    Biocenter Oulu, University of Oulu, 90014 Oulu, Finland
    Am J Physiol Lung Cell Mol Physiol 280:L214-20. 2001
    ..We conclude that there are specialized cells in the ET epithelium expressing and secreting SP-B and propose that SP-B may facilitate normal opening of the tube and mucociliary transport...

Research Grants28

  1. Bioengineering of Novel Synthetic Lipid-Peptide Lung Surfactants
    Robert H Notter; Fiscal Year: 2013
    ....
  2. Role of Angiogenic Agents in Alveolar Maturation and Injury
    Vineet Bhandari; Fiscal Year: 2013
    ..3) Characterize the effects of, and understand the mechanism(s) of antenatal VEGF activation and/or NO in the fetal lung exposed to hyperoxia. ..
  3. Development of a novel SP-B peptide lung surfactant
    Gary Fujii; Fiscal Year: 2013
    ....
  4. PERINATAL EXPRESSION OF SURFACTANT PROTEIN GENE SP-B
    Jeffrey Whitsett; Fiscal Year: 2002
    ..Further understanding of the role of SP-B in lung function and the mechanisms regulating SP-B may provide insights critical to developing new therapeutic strategies for prevention of lung disease in premature infants. ..
  5. De Novo Design of Lung Surfactant Protein B Mimics
    TICORA JONES; Fiscal Year: 2003
    ..As this last option provides room for non-protein treatments I plan to synthesize and characterize oligomeric and polymeric biomimetic materials that will serve as substitutes for lung surfactant protein SP-B. ..
  6. In Vivo Metabolism of Pulmonary Surfactant in Infants
    Aaron Hamvas; Fiscal Year: 2005
    ..abstract_text> ..
  7. ROLE OF SURFACTANT PROTEIN D IN SURFACTANT HOMEOSTASIS
    Machiko Ikegami; Fiscal Year: 2006
    ..The intended studies will provide fundamental insights into the role of SP-D in the protection of the lung, as well as into the basic mechanisms determining surfactant homeostasis. ..
  8. Transcriptional Control of Respiratory Epithelial Progenitor Cells
    Jeffrey A Whitsett; Fiscal Year: 2010
    ..A Stem Cell Consortium will be established at CCHMC, Univ. of Cincinnati College of Medicine to develop education, training, and research bridging hematopoietic stem cell and pulmonary stem cell biology on our campus. ..
  9. PERINATAL EXPRESSION OF SURFACTANT PROTEIN GENE SP-B
    Jeffrey Whitsett; Fiscal Year: 2007
    ..Transcriptional responses to decreased SP-B will be determined using RNA microarray, to identify the molecular pathways mediating or compensating for reduced SP-B/surfactant function in vivo. [unreadable] [unreadable]..
  10. SHH and Alveolar Formation
    Jeffrey Whitsett; Fiscal Year: 2006
    ..abstract_text> ..
  11. The Role of surfactant protein genetic variants in cyst*
    Joanna Floros; Fiscal Year: 2005
    ..aeruginosa and its clearance, and provide the basis for further consideration of novel therapeutic strategies to treat CF-related lung disease. ..
  12. OZONE EFFECTS ON FUNCTION OF SURFACTANT PROTEIN VARIANTS
    Joanna Floros; Fiscal Year: 2010
    ..Knowledge gained may help explain and perhaps link the in vitro data with the human genetic association data, and provide insight in the understanding of the value of the SP-A gene duplication. ..
  13. ABCA3 and Alveolar Homeostasis
    Jeffrey A Whitsett; Fiscal Year: 2010
    ....
  14. PPAR gamma Signaling and Lung Fibroblast Transdifferentiation
    Virender Rehan; Fiscal Year: 2009
    ..abstract_text> ..
  15. EVOLUTION OF IMMUNE RECOGNITION AND EVASION
    Austin L Hughes; Fiscal Year: 2010
    ..In addition, by increasing our understanding of the population diversity and evolutionary history of human immune system genes, this research will enhance our knowledge of human immune function in health and disease. ..
  16. Regulation of Inflammation in Asthma by Fas Ligand
    Angela Haczku; Fiscal Year: 2009
    ..Finally, in order to help support the hypothesis that pro-apoptotic FasL activity characterized in human airway cells is truly physiologic, we will perform challenge studies in mice under FasL neutralizing conditions. ..
  17. Surfactant-Protein Innate Immunity in an Asthma Model
    Angela Haczku; Fiscal Year: 2008
    ..The potential opportunity to interfere with allergic sensitization by SP-D treatment bears high clinical significance. [unreadable] [unreadable]..
  18. Interactive Mediators of Injury & Development
    Parviz Minoo; Fiscal Year: 2008
    ..1. ..
  19. Collectin Deficiency in the mouse
    Samuel Hawgood; Fiscal Year: 2004
    ..Although our studies are focused on a specific organism, we expect the mechanisms underlying collectin-IAV-host interactions will pertain more generally to the action of collectins in respiratory immune responses. ..
  20. MECHANOREGULATION OF ALVEOLAR CELL PHENOTYPIC EXPRESSION
    Jorge Gutierrez; Fiscal Year: 2004
    ....
  21. Gene Duplication and Genome Evolution
    Austin Hughes; Fiscal Year: 2004
    ..5) Examining the role of transposable elements in duplication of genomic segments by testing for nonrandom association between these elements and putatively duplicated blocks in the yeast genome. ..
  22. VEGF regulation of surfactant proteins in preventing RSV
    DAVID MEYERHOLZ; Fiscal Year: 2005
    ....
  23. Metals in exhaled breath condensate as COPD biomarkers
    Antonio Mutti; Fiscal Year: 2005
    ..abstract_text> ..
  24. Role of TGF-Alpha in Pulmonary Vascular Disease
    TIMOTHY LE CRAS; Fiscal Year: 2006
    ..This information will serve as a basis for developing therapeutic strategies aimed at improving lung growth and preventing pulmonary hypertension in premature babies and adults. ..
  25. REGULATION OF LUNG SURFACTANT PROTEIN B GENE EXPRESSION
    Vijayakumar Boggaram; Fiscal Year: 2006
    ..Such information may facilitate the development of newer therapies to treat lung dysfunction due to SP-B deficiency that occurs under conditions of elevated nitric oxide production in the lung. ..
  26. FASEB Summer Research Conference, Lung Surfactant: Molecular and Cell Biology
    Samuel Hawgood; Fiscal Year: 2006
    ..unreadable] 5. Collectins and mucosal host defense. [unreadable] 6. Design of novel surfactant-based therapeutics. [unreadable] [unreadable] [unreadable] [unreadable]..
  27. TRANSFORMING GROWTH FACTOR BETA IN OXIDANT LUNG INJURY
    MICHAEL O REILLY; Fiscal Year: 2002
    ..These studies are significant because understanding how ROS injure and kill pulmonary epithelial cells is critically important for improving clinical therapies that rely on supplemental oxygen. ..