myelin proteins

Summary

Summary: Proteins found in the myelin sheath. The major proteins of central nervous system myelin include: MYELIN PROTEOLIPID PROTEIN; MYELIN BASIC PROTEINS; and MYELIN-ASSOCIATED GLYCOPROTEIN. The major proteins of peripheral nervous system myelin include: MYELIN BASIC PROTEINS (myelin P1 protein and MYELIN P2 PROTEIN); MYELIN P0 PROTEIN; and MYELIN-ASSOCIATED GLYCOPROTEIN.

Top Publications

  1. ncbi A class of membrane proteins shaping the tubular endoplasmic reticulum
    Gia K Voeltz
    Howard Hughes Medical Institute and Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA
    Cell 124:573-86. 2006
  2. ncbi Immunology of multiple sclerosis
    Mireia Sospedra
    Cellular Immunology Section, Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 1400, USA
    Annu Rev Immunol 23:683-747. 2005
  3. pmc The nogo receptor family restricts synapse number in the developing hippocampus
    Zachary P Wills
    Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA
    Neuron 73:466-81. 2012
  4. ncbi LINGO-1 is a component of the Nogo-66 receptor/p75 signaling complex
    Sha Mi
    Department of Discovery Biology, Biogen Idec, Inc, 14 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nat Neurosci 7:221-8. 2004
  5. ncbi Functions of Nogo proteins and their receptors in the nervous system
    Martin E Schwab
    University of Zurich and ETH, Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Nat Rev Neurosci 11:799-811. 2010
  6. pmc Experience-driven plasticity of visual cortex limited by myelin and Nogo receptor
    Aaron W McGee
    Department of Neurology, Yale University School of Medicine, New Haven, CT 06520, USA
    Science 309:2222-6. 2005
  7. ncbi Identification of the Nogo inhibitor of axon regeneration as a Reticulon protein
    T GrandPre
    Department of Neurology, Yale University School of Medicine, New Haven, Connecticut, USA
    Nature 403:439-44. 2000
  8. ncbi P75 interacts with the Nogo receptor as a co-receptor for Nogo, MAG and OMgp
    Kevin C Wang
    Division of Neuroscience, Children s Hospital and Program in Neuroscience, Harvard Medical School, 320 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nature 420:74-8. 2002
  9. pmc NogoA restricts synaptic plasticity in the adult hippocampus on a fast time scale
    Andrea Delekate
    Division of Cellular Neurobiology, Zoological Institute, TU Braunschweig, 38106 Braunschweig, Germany
    Proc Natl Acad Sci U S A 108:2569-74. 2011
  10. ncbi Nogo-A inhibits neurite outgrowth and cell spreading with three discrete regions
    Thomas Oertle
    Brain Research Institute, University of Zurich, and Department of Biology, Swiss Federal Institute of Technology, CH 8057 Zurich, Switzerland
    J Neurosci 23:5393-406. 2003

Detail Information

Publications293 found, 100 shown here

  1. ncbi A class of membrane proteins shaping the tubular endoplasmic reticulum
    Gia K Voeltz
    Howard Hughes Medical Institute and Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA
    Cell 124:573-86. 2006
    ..The simultaneous absence of the reticulons and Yop1p in S. cerevisiae results in disrupted tubular ER. We propose that these "morphogenic" proteins partition into and stabilize highly curved ER membrane tubules...
  2. ncbi Immunology of multiple sclerosis
    Mireia Sospedra
    Cellular Immunology Section, Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 1400, USA
    Annu Rev Immunol 23:683-747. 2005
    ..It is now clear that MS is not just a disease of the immune system, but that factors contributed by the central nervous system are equally important and must be considered in the future...
  3. pmc The nogo receptor family restricts synapse number in the developing hippocampus
    Zachary P Wills
    Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA
    Neuron 73:466-81. 2012
    ..These findings suggest that NgR1, a receptor previously shown to restrict axon growth in the adult, also functions in the dendrite as a barrier that limits excitatory synapse number during brain development...
  4. ncbi LINGO-1 is a component of the Nogo-66 receptor/p75 signaling complex
    Sha Mi
    Department of Discovery Biology, Biogen Idec, Inc, 14 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nat Neurosci 7:221-8. 2004
    ..This effect on neurons was mimicked using an exogenously added human LINGO-1-Fc fusion protein. Together these observations suggest that LINGO-1 has an important role in CNS biology...
  5. ncbi Functions of Nogo proteins and their receptors in the nervous system
    Martin E Schwab
    University of Zurich and ETH, Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Nat Rev Neurosci 11:799-811. 2010
    ..In addition, Nogo proteins interact with various intracellular components and may have roles in the regulation of endoplasmic reticulum (ER) structure, processing of amyloid precursor protein and cell survival...
  6. pmc Experience-driven plasticity of visual cortex limited by myelin and Nogo receptor
    Aaron W McGee
    Department of Neurology, Yale University School of Medicine, New Haven, CT 06520, USA
    Science 309:2222-6. 2005
    ..After pathological trauma, similar NgR signaling limits functional recovery and axonal regeneration...
  7. ncbi Identification of the Nogo inhibitor of axon regeneration as a Reticulon protein
    T GrandPre
    Department of Neurology, Yale University School of Medicine, New Haven, Connecticut, USA
    Nature 403:439-44. 2000
    ..These data provide a molecular basis to assess the contribution of Nogo to the failure of axonal regeneration in the adult CNS...
  8. ncbi P75 interacts with the Nogo receptor as a co-receptor for Nogo, MAG and OMgp
    Kevin C Wang
    Division of Neuroscience, Children s Hospital and Program in Neuroscience, Harvard Medical School, 320 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nature 420:74-8. 2002
    ..Thus, interfering with p75 and its downstream signalling pathways may allow lesioned axons to overcome most of the inhibitory activities associated with central nervous system myelin...
  9. pmc NogoA restricts synaptic plasticity in the adult hippocampus on a fast time scale
    Andrea Delekate
    Division of Cellular Neurobiology, Zoological Institute, TU Braunschweig, 38106 Braunschweig, Germany
    Proc Natl Acad Sci U S A 108:2569-74. 2011
    ..NogoA could thus serve as an important negative regulator of functional and structural plasticity in mature neuronal networks...
  10. ncbi Nogo-A inhibits neurite outgrowth and cell spreading with three discrete regions
    Thomas Oertle
    Brain Research Institute, University of Zurich, and Department of Biology, Swiss Federal Institute of Technology, CH 8057 Zurich, Switzerland
    J Neurosci 23:5393-406. 2003
    ..This suggests that Nogo-A could have a second membrane topology. The two proposed topological variants may have different intracellular as well as extracellular functions...
  11. pmc Th1, Th17, and Th9 effector cells induce experimental autoimmune encephalomyelitis with different pathological phenotypes
    Anneli Jäger
    Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 183:7169-77. 2009
    ....
  12. pmc Resistance to experimental autoimmune encephalomyelitis in mice lacking the CC chemokine receptor (CCR)2
    L Izikson
    Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Exp Med 192:1075-80. 2000
    ..These data indicate that CCR2 plays a necessary and nonredundant role in the pathogenesis of EAE...
  13. ncbi A reticular rhapsody: phylogenic evolution and nomenclature of the RTN/Nogo gene family
    Thomas Oertle
    Brain Research Institute, University of Zurich, and Department of Biology, ETH Zurich, 8057 Zurich, Switzerland
    FASEB J 17:1238-47. 2003
    ..These data emphasize on the one hand the universal role of reticulons in the eukaryotic system and on the other hand the acquisition of putative new functions through acquirement of novel amino-terminal exons...
  14. pmc Reactivity to myelin antigens in multiple sclerosis. Peripheral blood lymphocytes respond predominantly to myelin oligodendrocyte glycoprotein
    N Kerlero de Rosbo
    Neuroimmunology Laboratory, La Trobe University, Bundoora, Australia
    J Clin Invest 92:2602-8. 1993
    Although T cell responses to the quantitatively major myelin proteins, myelin basic protein (MBP) and proteolipid protein (PLP), are likely to be of importance in the course of multiple sclerosis (MS), cell-mediated autoimmune responses ..
  15. ncbi Quantitative and integrative proteome analysis of peripheral nerve myelin identifies novel myelin proteins and candidate neuropathy loci
    Julia Patzig
    Department of Neurogenetics, and Proteomics Group, Max Planck Institute of Experimental Medicine, D 37075 Gottingen, Germany
    J Neurosci 31:16369-86. 2011
    ..We therefore hypothesized that only a fraction of all relevant myelin proteins has been identified so far...
  16. ncbi Recovery and brain reorganization after stroke in adult and aged rats
    Tiffanie M Markus
    Neuroscience and Aging Institute, Loyola University Chicago, Maywood, IL, USA
    Ann Neurol 58:950-3. 2005
    ....
  17. ncbi Nogo-A stabilizes the architecture of hippocampal neurons
    Marta Zagrebelsky
    Zoological Institute, Division of Cellular Neurobiology, University of Braunschweig, D 38106 Braunschweig, Germany
    J Neurosci 30:13220-34. 2010
    ..Mechanistically, although the majority of the activity of Nogo-A relies on a receptor-mediated mechanism involving NgR1, its cell-autonomous function plays a minor role...
  18. ncbi Localization of Nogo-A and Nogo-66 receptor proteins at sites of axon-myelin and synaptic contact
    Xingxing Wang
    Departments of Neurology and Neurosurgery and Section of Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Neurosci 22:5505-15. 2002
    ..Taken together, these data confirm the apposition of Nogo ligand and NgR receptor in situations of limited axonal regeneration and support the hypothesis that this system regulates CNS axonal plasticity and recovery from injury...
  19. pmc CC chemokine receptor 2 is critical for induction of experimental autoimmune encephalomyelitis
    B T Fife
    Department of Pathology, Northwestern University Medical School, Chicago, Illinois 60611, USA
    J Exp Med 192:899-905. 2000
    ..These results suggest that CCR2 expression on host-derived mononuclear cells is critical for disease induction...
  20. ncbi Cortical sensory map rearrangement after spinal cord injury: fMRI responses linked to Nogo signalling
    Toshiki Endo
    Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    Brain 130:2951-61. 2007
    ..In such situations, methods to control cortical plasticity, possibly by targeting Nogo signalling, may become helpful...
  21. ncbi TAJ/TROY, an orphan TNF receptor family member, binds Nogo-66 receptor 1 and regulates axonal regeneration
    Zhaohui Shao
    Department of Discovery Biology, Biogen Idec, Inc, 14 Cambridge Center, Cambridge, MA 02142, USA
    Neuron 45:353-9. 2005
    ..Given the limited expression of p75, the discovery of TAJ function is an important step for understanding the regulation of axonal regeneration...
  22. ncbi Nogo receptor antagonism promotes stroke recovery by enhancing axonal plasticity
    Jung Kil Lee
    Department of Neurology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Neurosci 24:6209-17. 2004
    ..Behavioral improvement occurs when therapy is initiated 1 week after arterial occlusion. Thus, delayed pharmacological blockade of the NgR promotes subacute stroke recovery by facilitating axonal plasticity...
  23. ncbi Increased A beta peptides and reduced cholesterol and myelin proteins characterize white matter degeneration in Alzheimer's disease
    Alex E Roher
    The Longtine Center for Molecular Biology and Genetics and Harold Civin Laboratory of Neuropathology, Sun Health Research Institute, Sun City, Arizona 85351, USA
    Biochemistry 41:11080-90. 2002
    ..To accurately assess the success of future therapeutic interventions, it is necessary to have a complete appreciation of the full scope and extent of AD pathology...
  24. ncbi IFN-gamma plays a critical down-regulatory role in the induction and effector phase of myelin oligodendrocyte glycoprotein-induced autoimmune encephalomyelitis
    D O Willenborg
    Neuroscience Research Unit, The Canberra Hospital, Australia
    J Immunol 157:3223-7. 1996
    ..These results indicate that IFN-gamma is not essential for the generation or function of anti-MOG35-55 effector cells but does play an important role in down-regulating EAE at both the effector and induction phase of disease...
  25. pmc Identification of a pathogenic antibody response to native myelin oligodendrocyte glycoprotein in multiple sclerosis
    Dun Zhou
    Department of Neurology, Heinrich Heine University, Moorenstrasse 5, 40225 Dusseldorf, Germany
    Proc Natl Acad Sci U S A 103:19057-62. 2006
    ..Overall these findings suggest a pathogenic antibody response to native MOG in a subgroup of MS patients...
  26. pmc Oligodendrocyte-myelin glycoprotein and Nogo negatively regulate activity-dependent synaptic plasticity
    Stephen J Raiker
    Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Neurosci 30:12432-45. 2010
    ..Thus, myelin inhibitors and their receptors may coordinate structural and functional neuronal plasticity in CNS health and disease...
  27. ncbi Rhesus monkeys are highly susceptible to experimental autoimmune encephalomyelitis induced by myelin oligodendrocyte glycoprotein: characterisation of immunodominant T- and B-cell epitopes
    N Kerlero de Rosbo
    Department of Immunology, The Weizmann Institute of Science, 76100, Rehovot, Israel
    J Neuroimmunol 110:83-96. 2000
    ..A strong B cell response to MOG was observed in all monkeys and major epitopes recognized were located within amino acids 4-26, 24-46 and 44-66/54-76...
  28. ncbi A role for Nogo receptor in macrophage clearance from injured peripheral nerve
    Elizabeth J Fry
    Center for Research in Neuroscience, The McGill University Health Center, 1650 Cedar Avenue, Montreal, Quebec, Canada
    Neuron 53:649-62. 2007
    ..These data have implications for the resolution of inflammation in peripheral nerve and CNS pathologies...
  29. pmc Cognitive outcome following brain injury and treatment with an inhibitor of Nogo-A in association with an attenuated downregulation of hippocampal growth-associated protein-43 expression
    Niklas Marklund
    Traumatic Brain Injury Laboratory, Department of Neurosurgery, University of Pennsylvania, Philadelphia, USA
    J Neurosurg 107:844-53. 2007
    ..To elucidate a potential molecular response to Nogo-A inhibition, we evaluated the effects of 7B12 on hippocampal GAP-43 expression...
  30. ncbi Neuregulin 1-erbB signaling is necessary for normal myelination and sensory function
    Suzhen Chen
    Division of Neuroscience, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 26:3079-86. 2006
    ..These results suggest that disruption of the NRG1-erbB signaling pathway could contribute to the pathogenesis of peripheral neuropathies with hypomyelination and neuropathic pain...
  31. pmc Subcutaneous Nogo receptor removes brain amyloid-beta and improves spatial memory in Alzheimer's transgenic mice
    James H Park
    Program in Cellular Neuroscience, Neurodegeneration, and Repair, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Neurosci 26:13279-86. 2006
    ..The benefits of peripheral NgR administration are evident when therapy is initiated after disease onset. Thus, the peripheral association of NgR(310)ecto-Fc with central Abeta residues provides an effective therapeutic approach for AD...
  32. pmc Rituximab reduces B cells and T cells in cerebrospinal fluid of multiple sclerosis patients
    Anne H Cross
    Box 8111, Department of Neurology, Washington University School of Medicine, 660 S Euclid Avenue, Saint Louis, MO 63110, USA
    J Neuroimmunol 180:63-70. 2006
    ..In summary, rituximab depleted B cells from CSF at 24 weeks after initial treatment, and this B cell depletion was associated with a reduction in CSF T cells as well...
  33. ncbi Double trouble in hereditary neuropathy: concomitant mutations in the PMP-22 gene and another gene produce novel phenotypes
    Julie A Hodapp
    Department of Rehabilitation Medicine, School of Medicine, University of Washington, Seattle, USA
    Arch Neurol 63:112-7. 2006
    ..Mutations in the peripheral myelin protein 22 (PMP-22) gene are the most common cause of Charcot-Marie-Tooth neuropathy and may rarely occur in combination with other neurogenetic diseases...
  34. ncbi Mammaglobin a: a promising marker for breast cancer
    Neil O'Brien
    Department of Nuclear Medicine, St Vincent s University Hospital, Dublin 4, Ireland
    Clin Chem 48:1362-4. 2002
  35. pmc Myelin oligodendrocyte glycoprotein-specific T cell receptor transgenic mice develop spontaneous autoimmune optic neuritis
    Estelle Bettelli
    Center for Neurologic Diseases, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Exp Med 197:1073-81. 2003
    ..These results demonstrate that clinical manifestations of CNS autoimmune disease will vary depending on the identity of the target autoantigen and that MOG-specific T cell responses are involved in the genesis of isolated optic neuritis...
  36. pmc Neuronal Nogo-A regulates glutamate receptor subunit expression in hippocampal neurons
    Xiangmin Peng
    Department of Neurology, University of Michigan and VA Ann Arbor Healthcare System, Ann Arbor, Michigan 48109, USA
    J Neurochem 119:1183-93. 2011
    ....
  37. ncbi Patterns of Nogo mRNA and protein expression in the developing and adult rat and after CNS lesions
    Andrea B Huber
    Brain Research Institute, University of Zurich, Zurich, 8057 Switzerland
    J Neurosci 22:3553-67. 2002
    ....
  38. ncbi Wnt signaling is sufficient to perturb oligodendrocyte maturation
    Keith Feigenson
    Department of Research Neurology, Children s Hospital of Philadelphia, Philadelphia, PA, USA
    Mol Cell Neurosci 42:255-65. 2009
    ..These results indicate that activating the Wnt/beta-catenin pathway delays the development of myelinating oligodendrocytes...
  39. pmc Spontaneous relapsing-remitting EAE in the SJL/J mouse: MOG-reactive transgenic T cells recruit endogenous MOG-specific B cells
    Bernadette Pöllinger
    Department of Neuroimmunology, Max Planck Institute of Neurobiology, D 82152 Martinsried, Germany
    J Exp Med 206:1303-16. 2009
    ..The secreted autoantibodies are pathogenic, enhancing demyelinating EAE episodes. RR mice constitute the first spontaneous animal model for the most common form of multiple sclerosis (MS), RR MS...
  40. pmc Neuronal Nogo-A negatively regulates dendritic morphology and synaptic transmission in the cerebellum
    Marija M Petrinovic
    Brain Research Institute, University of Zurich, 8057 Zurich, Switzerland
    Proc Natl Acad Sci U S A 110:1083-8. 2013
    ..Thus, Nogo-A appears as a negative regulator of PC input synapses, which orchestrates cerebellar connectivity through regulation of synapse morphology and the size of the PC dendritic tree...
  41. ncbi Functional recovery and neuroanatomical plasticity following middle cerebral artery occlusion and IN-1 antibody treatment in the adult rat
    Catherine M Papadopoulos
    Neurology and Research Services, Hines Veterans Affairs Hospital, Hines, IL 60153, USA
    Ann Neurol 51:433-41. 2002
    ..These results support the efficacy of Nogo-A blockade as a treatment for ischemic stroke and implicate plasticity from the unlesioned hemisphere as a mechanism for recovery...
  42. ncbi Nogo-A, -B, and -C are found on the cell surface and interact together in many different cell types
    Dana A Dodd
    Brain Research Institute, University of Zurich and Department of Biology, ETH Zurich, CH 8057 Zurich, Switzerland
    J Biol Chem 280:12494-502. 2005
    ..Nogo-A, -B, and -C share a 180-amino acid C-terminal domain with two highly conserved hydrophobic stretches that could form a channel or transporter in the ER and/or on the cell surface...
  43. ncbi A TNF receptor family member, TROY, is a coreceptor with Nogo receptor in mediating the inhibitory activity of myelin inhibitors
    Jong Bae Park
    Division of Neuroscience, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Neuron 45:345-51. 2005
    ..Our results implicate TROY in mediating myelin inhibition, offering new insights into the molecular mechanisms of regeneration failure in the adult nervous system...
  44. pmc Pharmacological induction of the heat shock response improves myelination in a neuropathic model
    Sunitha Rangaraju
    Department of Neuroscience, College of Medicine, McKnight Brain Institute, University of Florida, Gainesville, FL 32610 0244, USA
    Neurobiol Dis 32:105-15. 2008
    ..These results warrant further studies with HSP90 inhibitors as potential therapeutic candidates for hereditary demyelinating neuropathies...
  45. ncbi Additive effect of the combination of glatiramer acetate and minocycline in a model of MS
    Fabrizio Giuliani
    Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada
    J Neuroimmunol 158:213-21. 2005
    ..This combination resulted in a significant reduction of disease severity and disease burden with attenuation of the inflammation, axonal loss and demyelination...
  46. ncbi Biology of oligodendrocyte and myelin in the mammalian central nervous system
    N Baumann
    Institut National de la Santé et de la Recherche Médicale U 495, Biology of Neuron Glia Interactions, Salpetriere Hospital, Paris, France
    Physiol Rev 81:871-927. 2001
    ..There is also a remarkable plasticity of the oligodendrocyte lineage, even in the adult with a certain potentiality for myelin repair after experimental demyelination or human diseases...
  47. ncbi Wnt/beta-catenin signaling is an essential and direct driver of myelin gene expression and myelinogenesis
    Marcel Tawk
    Unité Mixte de Recherche 788, INSERM and University Paris Sud 11, Biomedical Institute of Bicêtre, 94276 Kremlin Bicêtre, France
    J Neurosci 31:3729-42. 2011
    ..The present findings attribute to Wnt/β-catenin pathway components an essential role in myelin gene expression and myelinogenesis...
  48. pmc Genetic deletion and pharmacological inhibition of Nogo-66 receptor impairs cognitive outcome after traumatic brain injury in mice
    Anders Hånell
    Department of Neurosurgery, Uppsala University, Uppsala, Sweden
    J Neurotrauma 27:1297-309. 2010
    ..Our data suggest a complex role for myelin-associated inhibitors in the behavioral recovery process following TBI, and urge caution when inhibiting NgR1 in the early post-injury period...
  49. ncbi TACE-induced cleavage of NgR and p75NTR in dorsal root ganglion cultures disinhibits outgrowth and promotes branching of neurites in the presence of inhibitory CNS myelin
    Zubair Ahmed
    Molecular Neuroscience Group, Division of Medical Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    FASEB J 20:1939-41. 2006
    ..Thus, TACE-induced cleavage of NgR and RIP of p75(NTR) abrogates axon growth inhibitory signaling, thereby disinhibiting CNS axon/neurite growth...
  50. ncbi Transport of Trembler-J mutant peripheral myelin protein 22 is blocked in the intermediate compartment and affects the transport of the wild-type protein by direct interaction
    A R Tobler
    Department of Neurobiology, Stanford University School of Medicine, Stanford, California 94305 5125, USA
    J Neurosci 19:2027-36. 1999
    ..The neuropathy itself appears to result both from decreased trafficking of wt-PMP22 to the plasma membrane and from a toxic gain of function via the accumulation of wt- and TrJ-PMP22 in the intermediate compartment...
  51. ncbi The Nogo-66 receptor: focusing myelin inhibition of axon regeneration
    Aaron W McGee
    Departments of Neurology and Neurobiology, Yale University School of Medicine, PO Box 208018, New Haven, CT 06520, USA
    Trends Neurosci 26:193-8. 2003
    ..Although these findings expand our understanding of the molecular determinants of adult CNS axonal regrowth, the physiological roles of myelin-associated inhibitors in the intact adult CNS remain ill-defined...
  52. ncbi Neuroactive steroids and peripheral myelin proteins
    V Magnaghi
    Department of Endocrinology and Center of Excellence for Neurodegenerative Disorders, University of Milan, Via Balzaretti 9, 20133, Milan, Italy
    Brain Res Brain Res Rev 37:360-71. 2001
    ..DHT) and 5alpha-androstan-3alpha,17beta-diol (3alpha-diol)) in the control of the gene expression of myelin proteins (i.e. glycoprotein Po (Po) and the peripheral myelin protein 22 (PMP22)) in the peripheral nervous system...
  53. ncbi Treatment with chimeric anti-human CD40 antibody suppresses MRI-detectable inflammation and enlargement of pre-existing brain lesions in common marmosets affected by MOG-induced EAE
    Bert A 't Hart
    Department of Immunobiology, Biomedical Primate Research Center, Rijswijk, The Netherlands
    J Neuroimmunol 163:31-9. 2005
    ....
  54. pmc Spontaneous opticospinal encephalomyelitis in a double-transgenic mouse model of autoimmune T cell/B cell cooperation
    Gurumoorthy Krishnamoorthy
    Department of Neuroimmunology, Max Planck Institute for Neurobiology, Martinsried, Germany
    J Clin Invest 116:2385-92. 2006
    ..In addition, in OSE mice, but not in single-transgenic parental mice, anti-MOG antibodies were switched from IgM to IgG1...
  55. ncbi Temporal expression pattern of peripheral myelin protein 22 during in vivo and in vitro myelination
    L Notterpek
    Department of Neurobiology, Stanford University School of Medicine, California 94305, USA
    Glia 25:358-69. 1999
    ....
  56. pmc Reshaping of the endoplasmic reticulum limits the rate for nuclear envelope formation
    Daniel J Anderson
    Molecular and Cell Biology Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    J Cell Biol 182:911-24. 2008
    ..Our results provide evidence that ER-shaping proteins are directly involved in the reconstruction of the nuclear compartment and that morphological restructuring of the ER is the principal mechanism of NE formation in vivo...
  57. ncbi Effects of progesterone on oligodendrocyte progenitors, oligodendrocyte transcription factors, and myelin proteins following spinal cord injury
    Florencia Labombarda
    Laboratory of Neuroendocrine Biochemistry, Instituto de Biologia y Medicina Experimental, CONICET, Buenos Aires, Argentina
    Glia 57:884-97. 2009
    ..Thus, progesterone effects on oligodendrogenesis and myelin proteins may constitute fundamental steps for repairing traumatic injury inflicted to the spinal cord.
  58. pmc White matter inhibitors in CNS axon regeneration failure
    Fang Xie
    Department of Neurosciences, University of California San Diego, La Jolla, CA 92093 0691, USA
    Exp Neurol 209:302-12. 2008
    ....
  59. ncbi Effects of mouse strain, position of integration and tetracycline analogue on the tetracycline conditional system in transgenic mice
    Andrea Robertson
    Imperial College School of Science, Technology and Medicine, Division of Biomedical Sciences and Clinical Sciences Centre, London, UK
    Gene 282:65-74. 2002
    ..We found that expression became uniform between mice, and occurred in a higher proportion of cells, when the transgenes were crossed onto the CBA/Ca background in comparison with the C57BL/6J background...
  60. ncbi LGI1 is a Nogo receptor 1 ligand that antagonizes myelin-based growth inhibition
    Rhalena Thomas
    Centre for Neuronal Survival, Montreal Neurological Institute, McGill University, Montreal, Quebec H3A 2B4, Canada
    J Neurosci 30:6607-12. 2010
    ..Finally, we demonstrate that NgR1 and ADAM22 physically associate to form a receptor complex in which NgR1 facilitates LGI1 binding to ADAM22...
  61. ncbi Glucocorticosteroids stimulate the activity of the promoters of peripheral myelin protein-22 and protein zero genes in Schwann cells
    F Desarnaud
    INSERM U488, 80, rue du General Leclerc, 94276, Le Kremlin Bicetre, France
    Brain Res 865:12-6. 2000
    ..Thus, the activation by GLUC of the promoter activities of two peripheral myelin protein genes is Schwann cell-specific...
  62. ncbi Initial events of myelination involve Fyn tyrosine kinase signalling
    H Umemori
    Department of Oncology, University of Tokyo, Japan
    Nature 367:572-6. 1994
    ..These results indicate that Fyn participates in the initial events of myelination as a signalling molecule downstream of large MAG; indeed, we find that fyn-deficient mice exhibit impaired myelination...
  63. pmc Nogo receptor 1 regulates formation of lasting memories
    Alexandra Karlén
    Department of Neuroscience, Karolinska Institutet, Retzius vag 8, 171 77 Stockholm, Sweden
    Proc Natl Acad Sci U S A 106:20476-81. 2009
    ..Understanding the molecular underpinnings of synaptic rearrangements that carry lasting memories may facilitate development of treatments for memory dysfunction...
  64. pmc Reticulon-4A (Nogo-A) redistributes protein disulfide isomerase to protect mice from SOD1-dependent amyotrophic lateral sclerosis
    Yvonne S Yang
    Program in Cellular Neuroscience, Neurodegeneration, and Repair, Yale University School of Medicine, New Haven, CT 06510, USA
    J Neurosci 29:13850-9. 2009
    ..Our results provide a novel intracellular role for reticulon proteins and support the hypothesis that modulation of PDI function is a potential therapeutic approach to ALS...
  65. ncbi Nogo-A and nogo receptor expression in demyelinating lesions of multiple sclerosis
    Jun ichi Satoh
    Department of Immunology, National Institute of Neuroscience, NCNP, Tokyo, Japan
    J Neuropathol Exp Neurol 64:129-38. 2005
    ....
  66. pmc The N-terminal domain of Nogo-A inhibits cell adhesion and axonal outgrowth by an integrin-specific mechanism
    Fenghua Hu
    Program in Cellular Neuroscience, Neurodegeneration and Repair, Department of Neurology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Neurosci 28:1262-9. 2008
    ..Both alpha(v) and alpha5 integrins have widespread expression in adult brain and are found in axonal growth cones. Thus, inhibition of integrin signaling by Amino-Nogo contributes to the failure of CNS axon regeneration...
  67. ncbi Fast progression of recombinant human myelin/oligodendrocyte glycoprotein (MOG)-induced experimental autoimmune encephalomyelitis in marmosets is associated with the activation of MOG34-56-specific cytotoxic T cells
    Yolanda S Kap
    Department of Immunobiology, Biomedical Primate Research Centre, Rijswijk, The Netherlands
    J Immunol 180:1326-37. 2008
    ..The phenotype and cytotoxic activity suggest that these cells are NK-CTL. These results support the concept that cytotoxic cells may play a role in the pathogenesis of multiple sclerosis...
  68. ncbi Highly reactive anti-myelin oligodendrocyte glycoprotein antibodies differentiate demyelinating diseases from viral encephalitis in children
    P H Lalive
    Department of Neurosciences, Division of Neurology, University Hospital of Geneva, Geneva, Switzerland
    Mult Scler 17:297-302. 2011
    ..In adults reported anti-MOG antibody frequencies have been variable across a number of studies and can also be detected in controls...
  69. ncbi Therapeutic administration of progesterone antagonist in a model of Charcot-Marie-Tooth disease (CMT-1A)
    Michael W Sereda
    Max Planck Institute of Experimental Medicine, Department of Neurogenetics, Hermann Rein Str 3, D 37075 Gottingen, Germany
    Nat Med 9:1533-7. 2003
    ..Taken together, these data provide proof of principle that the progesterone receptor of myelin-forming Schwann cells is a promising pharmacological target for therapy of CMT-1A...
  70. pmc Dicer1 and miR-219 Are required for normal oligodendrocyte differentiation and myelination
    Jason C Dugas
    Department of Neurobiology, Stanford University School of Medicine, Stanford, CA 94305 5125, USA
    Neuron 65:597-611. 2010
    ..Together, these findings show that miR-219 plays a critical role in coupling differentiation to proliferation arrest in the OL lineage, enabling the rapid transition from proliferating OPCs to myelinating OLs...
  71. ncbi Assembly of CNS myelin in the absence of proteolipid protein
    M Klugmann
    Zentrum für Molekulare Biologie ZMBH University of Heidelburg, Federal Republic of Germany
    Neuron 18:59-70. 1997
    ..Dysmyelination and oligodendrocyte death emerge as an epiphenomenon of other PLP mutations and have been uncoupled in the PLP null allele from the risk of premature myelin breakdown...
  72. ncbi Nogo-A-deficient mice reveal strain-dependent differences in axonal regeneration
    Leda Dimou
    Brain Research Institute, University of Zurich, Department Biology, Swiss Federal Institute of Technology, CH 8057 Zurich, Switzerland
    J Neurosci 26:5591-603. 2006
    ....
  73. ncbi Relevant antibody subsets against MOG recognize conformational epitopes exclusively exposed in solid-phase ELISA
    Til Menge
    University of California San Francisco, Department of Neurology, San Francisco CA, USA
    Eur J Immunol 37:3229-39. 2007
    ..Thus, the accurate detection of important subsets of pathogenic anti-MOG antibodies requires methods in which MOG is displayed similarly to its natural conformation in myelin...
  74. ncbi Systemic deletion of the myelin-associated outgrowth inhibitor Nogo-A improves regenerative and plastic responses after spinal cord injury
    Marjo Simonen
    Brain Research Institute, University of Zurich, CH 8057, Zurich, Switzerland
    Neuron 38:201-11. 2003
    ..CST fibers caudal to the lesion-regenerating and/or sprouting from spared intact fibers-were also found to be more frequent in Nogo-A-deficient animals...
  75. pmc Pathogenic myelin oligodendrocyte glycoprotein antibodies recognize glycosylated epitopes and perturb oligodendrocyte physiology
    Cecilia B Marta
    Department of Neuroscience, University of Connecticut Medical School, Farmington, CT 06030 3401, USA
    Proc Natl Acad Sci U S A 102:13992-7. 2005
    ....
  76. pmc Granulocyte macrophage colony-stimulating factor: a new putative therapeutic target in multiple sclerosis
    J L McQualter
    Neuroimmunology Laboratory, Department of Biochemistry, La Trobe University, Victoria 3086, Australia
    J Exp Med 194:873-82. 2001
    ..These results hold implications for the pathogenesis of inflammatory and demyelinating diseases and may provide the basis for more effective therapies for inflammatory diseases, and more specifically for multiple sclerosis...
  77. ncbi PirB is a functional receptor for myelin inhibitors of axonal regeneration
    Jasvinder K Atwal
    Neurodegeneration Labs and Research Drug Discovery, Genentech, 1 DNA Way, South San Francisco, CA 94080, USA
    Science 322:967-70. 2008
    ....
  78. ncbi Alterations in degradative pathways and protein aggregation in a neuropathy model based on PMP22 overexpression
    Jenny Fortun
    Department of Neuroscience, College of Medicine, McKnight Brain Institute, University of Florida, Gainesville, FL 32610, USA
    Neurobiol Dis 22:153-64. 2006
    ....
  79. ncbi Epithelial membrane proteins induce membrane blebbing and interact with the P2X7 receptor C terminus
    Heather L Wilson
    Institute of Molecular Physiology, University of Sheffield S10 2TN, United Kingdom
    J Biol Chem 277:34017-23. 2002
    ..These findings suggest that the P2X(7) C-terminal domain associates with EMPs, and this interaction may mediate some aspects of the downstream signaling following P2X(7) receptor activation...
  80. ncbi Prevention of experimental autoimmune encephalomyelitis in common marmosets using an anti-IL-12p40 monoclonal antibody
    Herbert P M Brok
    Department of Immunobiology, Biomedical Primate Research Center, Rijswijk, The Netherlands
    J Immunol 169:6554-63. 2002
    ..We demonstrate that anti-IL-12p40 treatment has a protective effect on the neurological dysfunction as well as on neuropathological changes normally observed in the brain and spinal cord of EAE-affected individuals...
  81. ncbi Progesterone derivatives are able to influence peripheral myelin protein 22 and P0 gene expression: possible mechanisms of action
    R C Melcangi
    Department of Endocrinology, University of Milan, Italy
    J Neurosci Res 56:349-57. 1999
    ..In conclusion, the present data show that the gene expression of two important peripheral myelin proteins can be influenced by progesterone derivatives...
  82. ncbi Expression profile of receptors for myelin-associated inhibitors of axonal regeneration in the intact and injured mouse central nervous system
    Benoit Barrette
    Department of Anatomy and Physiology, Laval University, Ste Foy, Quebec, Canada
    Mol Cell Neurosci 34:519-38. 2007
    ..Qualitative and quantitative analyses revealed that brain expression for these receptors was not affected by a severe T10 spinal cord contusion...
  83. ncbi DNA deletion associated with hereditary neuropathy with liability to pressure palsies
    P F Chance
    Department of Pediatrics, University of Utah Medical Center, Salt Lake City 84132
    Cell 72:143-51. 1993
    ..Furthermore, the breakpoints in HNPP and CMT1A map to the same intervals in 17p11.2, suggesting that these genetic disorders may be the result of reciprocal products of unequal crossover...
  84. ncbi ST2 is an inhibitor of interleukin 1 receptor and Toll-like receptor 4 signaling and maintains endotoxin tolerance
    Elizabeth K Brint
    Department of Biochemistry, Trinity College, Dublin 2, Ireland
    Nat Immunol 5:373-9. 2004
    ..Thus, these results provide a molecular explanation for the function of ST2 in T(H)2 responses, as inhibition of TLRs promotes a T(H)2 response, and also identify ST2 as a key regulator of endotoxin tolerance...
  85. ncbi Molecular diagnosis and clinical onset of Charcot-Marie-Tooth disease in Japan
    Akiko Abe
    Department of Pediatrics, Yamagata University School of Medicine, Yamagata, Japan
    J Hum Genet 56:364-8. 2011
    ..Low prevalence of PMP22 duplication is likely associated with the mild symptoms due to genetic and/or epigenetic modifying factors...
  86. pmc Role of Nogo-A in neuronal survival in the reperfused ischemic brain
    Ertugrul Kilic
    Department of Neurology, University Hospital Essen, Essen, Germany
    J Cereb Blood Flow Metab 30:969-84. 2010
    ..Clinical trials should be aware of injurious effects of axonal growth-promoting therapies. Thus, Nogo-A antibodies should not be used in the very acute stroke phase...
  87. pmc Cognitive recovery in the aged rat after stroke and anti-Nogo-A immunotherapy
    Rebecca L Gillani
    Neuroscience Program, Loyola University Chicago, Maywood, IL 60153, USA
    Behav Brain Res 208:415-24. 2010
    ..The identification of sites of axonal and dendritic plasticity in the aged brain after stroke and treatment with anti-Nogo-A immunotherapy is still under investigation...
  88. ncbi Neonatal hypoxia suppresses oligodendrocyte Nogo-A and increases axonal sprouting in a rodent model for human prematurity
    Jared Weiss
    Department of Neurology, Yale University School of Medicine, New Haven, CT 06520, USA
    Exp Neurol 189:141-9. 2004
    ..Thus, hypoxia-induced reduction in myelin-derived axon outgrowth inhibitors appears to contribute axonal misconnection to the pathology of very low birth weight infants...
  89. pmc Genetic variants of Nogo-66 receptor with possible association to schizophrenia block myelin inhibition of axon growth
    Stephane Budel
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut 06536, USA
    J Neurosci 28:13161-72. 2008
    ..For a restricted subset of individuals diagnosed with schizophrenia, the expression of dysfunctional NGR variants may contribute to increased disease risk...
  90. ncbi B-cell-deficient mice develop experimental allergic encephalomyelitis with demyelination after myelin oligodendrocyte glycoprotein sensitization
    P Hjelmstrom
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT 06520 8034, USA
    J Immunol 161:4480-3. 1998
    ..The inflammatory cells in the central nervous system of muMT mice included both activated and memory T cells and macrophages. The data suggest that B cells and Abs are not necessary for primary demyelination in MOG-induced EAE in mice...
  91. pmc Anatomical plasticity of adult brain is titrated by Nogo Receptor 1
    Feras V Akbik
    Cellular Neuroscience, Neurodegeneration and Repair Program, Departments of Neurology and Neurobiology, Yale University School of Medicine, New Haven, CT 06536, USA
    Neuron 77:859-66. 2013
    ..Thus, NgR1 determines the low set point for synaptic turnover in adult cerebral cortex...
  92. ncbi Increased expression of the Nogo receptor in the hippocampus and its relation to the neuropathology in Alzheimer's disease
    Hong yan Zhu
    Hefei National Laboratory for Physical Science at the Microscale, University of Science and Technology of China, Hefei 230026, PR China
    Hum Pathol 38:426-34. 2007
    ..These results suggest that NgR may be related to the formation of tangles in AD...
  93. pmc Amino-Nogo-A antagonizes reactive oxygen species generation and protects immature primary cortical neurons from oxidative toxicity
    Y J Mi
    Institute of Neurosciences, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, China
    Cell Death Differ 19:1175-86. 2012
    ..Our data suggest that neuronal Nogo-A might play a cell-autonomous role in improving neuronal survival against oxidative insult through interacting with Prdx2 and scavenging of ROS...
  94. pmc B lymphocytes producing demyelinating autoantibodies: development and function in gene-targeted transgenic mice
    T Litzenburger
    Max Planck Institut fur Neurobiologie, D 82152 Martinsried, Germany
    J Exp Med 188:169-80. 1998
    ..However, the presence of the transgene both accelerates and exacerbates experimental autoimmune encephalitis, irrespective of the identity of the initial autoimmune insult...
  95. ncbi Truncated soluble Nogo receptor binds Nogo-66 and blocks inhibition of axon growth by myelin
    Alyson E Fournier
    Department of Neurology and Section of Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Neurosci 22:8876-83. 2002
    ..These data suggest that NgR mediates a significant fraction of myelin inhibition of axon outgrowth...
  96. ncbi Sequential loss of myelin proteins during Wallerian degeneration in the human spinal cord
    A Buss
    Department of Neurology, Aachen University Medical School, Georg August Universitat Gottingen, Germany
    Brain 128:356-64. 2005
    ..However, in agreement with animal data, a sequential loss of myelin proteins was found which was dependent on their location within the myelin sheath...
  97. ncbi Disinhibition of neurite growth to repair the injured adult CNS: focusing on Nogo
    R R Gonzenbach
    Brain Research Institute, University of Zurich, Winterthurerstrasse 190, 8057, Zurich, Switzerland
    Cell Mol Life Sci 65:161-76. 2008
    ....
  98. pmc Tyrosine phosphorylation of MyD88 adapter-like (Mal) is critical for signal transduction and blocked in endotoxin tolerance
    Wenji Piao
    Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Biol Chem 283:3109-19. 2008
    ..Thus, tyrosine phosphorylation of Mal is required for adapter signaling, regulates Mal interactions with TLR4 and receptor signaling, and is inhibited in endotoxin tolerance...
  99. pmc Differential aggregation of the Trembler and Trembler J mutants of peripheral myelin protein 22
    Andreas R Tobler
    Department of Neurobiology, Stanford University School of Medicine, Stanford, CA 94305 5125, USA
    Proc Natl Acad Sci U S A 99:483-8. 2002
    ..Thus, the differences in the phenotypes of Tr and TrJ mice may depend more on the ability of the mutant protein to aggregate than on the dominant-negative effect of the mutant Pmp22 on wild-type Pmp22 trafficking...
  100. pmc Process outgrowth in oligodendrocytes is mediated by CNP, a novel microtubule assembly myelin protein
    John Lee
    Department of Biochemistry, McGill University, Montreal, Quebec, Canada
    J Cell Biol 170:661-73. 2005
    ..Accordingly, cultured OLs from CNP-deficient mice extend smaller outgrowths with less arborized processes. We propose that CNP is an important component of the cytoskeletal machinery that directs process outgrowth in OLs...
  101. ncbi Delayed treatment with monoclonal antibody IN-1 1 week after stroke results in recovery of function and corticorubral plasticity in adult rats
    Andrew B Seymour
    Neurology and Research Service, Hines VA Hospital, Roosevelt Road and Fifth Avenue, Hines, Illinois, USA
    J Cereb Blood Flow Metab 25:1366-75. 2005
    ....

Research Grants62

  1. CYTOKINES IN GLIAL CELLS AND EAE BRAIN
    Inderjit Singh; Fiscal Year: 2013
    ..involvement of RFGs mediated mechanisms in neuroprotection as revealed by reduced demyelination (loss of both myelin proteins and lipids) and loss of OL-progenitors in EAE...
  2. A human neuron/oligodendrocyte co-culture model to study myelination
    Bridget Shafit-Zagardo; Fiscal Year: 2013
    ..axonal ensheathment, and examine by immunofluorescent microscopy and electron microscopy the extent to which myelin proteins are expressed in the developing myelin sheath, whether compact myelin is achieved over time, and the ..
  3. PATHOGENESIS AND IMMUNOREGULATION OF PLP-INDUCED R-EAE
    Stephen D Miller; Fiscal Year: 2010
    ..recruitment of T cell responses against non-crossreactive endogenous myelin epitopes on the same or different myelin proteins (intramolecular or intermolecular epitope spreading)...
  4. REGULATION OF AUTOIMMUNITY WITH T CELL RECEPTOR PEPTIDES
    Arthur A Vandenbark; Fiscal Year: 2010
    ..for limiting inflammatory reactions mediated by Th1 cells directed at tissue-specific antigens such as myelin proteins. Data obtained from our clinical trials using TCR peptides to vaccinate patients with multiple sclerosis (MS) ..
  5. IMMUNOREGULATION AND PATHOLOGY OF CHRONIC-RELAPSING EAE
    Stephen D Miller; Fiscal Year: 2013
    ..activation of CD4+ T cell responses against non- crossreactive endogenous epitopes on the same or different myelin proteins (intramolecular or intermolecular epitope spreading)...
  6. Cellular events in heritable peripheral neuropathies
    Lucia Notterpek; Fiscal Year: 2013
    ..cytosolic aggregates of PMP22 form and recruit essential Schwann cell molecules, including chaperones and myelin proteins, which alter the protein balance of the cell...
  7. Molecular pathogenesis of SIMPLE in Charcot-Marie-Tooth disease
    MING HIN LEE; Fiscal Year: 2010
    ..patients and rodent disease models of CMT subtypes (CMT1A and CMT1B) revealed accumulations of peripheral myelin proteins, namely, peripheral myelin protein 22 (PMP22) and myelin protein zero (MPZ), to cytoplasmic inclusion bodies...
  8. Virus Infection Leads to Autoreactive T Cells Having Multiple TCRs
    Robert S Fujinami; Fiscal Year: 2013
    ..These T cells that recognize epitopes of myelin proteins then trigger a series of events that result in more inflammation in the CNS and myelin destruction...
  9. Axon-to-myelin spread and persistence of Theiler's murine encephalomyelitis virus
    ERIC CHARLES FREUNDT; Fiscal Year: 2010
    ..Mice bearing mutations in either of two major myelin proteins are resistant to persistent infection...
  10. MOLECULAR MECHANISMS OF SCHWANN CELL MYELINATION
    Bruce D Trapp; Fiscal Year: 2013
    ..Specific Aim 1 is focused on the role of the most abundant myelin proteins, P0 and PLP, by investigating the effects of replacing P0 with PLP in myelinating Schwann cells...
  11. Regulation of Myelination by Egr2/Nab Protein Complexes
    Jeffrey Milbrandt; Fiscal Year: 2009
    ..patients causes myelinopathy by acting as a dominant inhibitor of the normal EGR2-mediated expression of myelin proteins. Further study demonstrated that NAB proteins, which interact with EGR2 and modulate its transcriptional ..
  12. ASSEMBLY OF A NEURAL PLASMA MEMBRANE PROTEOLIPID
    Victor Sapirstein; Fiscal Year: 1990
    ..The relative rate of assembly of this protein into myelin will be determined and compared to other myelin proteins such as the major myelin proteolipid and the myelin associated glycoprotein...
  13. The role of TRAF6 in the regulation of neurite outgrowth
    ANA LUISA JORDAO PERDIGOTO; Fiscal Year: 2010
    ..specific aims of our research are to 1) Determine whether TRAF6 is required for axon outgrowth inhibition by myelin proteins 2) Evaluate whether TRAF6 is recruited by p75 following binding of the myelin inhibitory proteins to regulate ..
  14. THE ROLE OF MYELIN PROTEINS IN EXPERIMENTAL NEURITIS
    Steven Brostoff; Fiscal Year: 1990
    ....
  15. Myelin Biogenesis: Vesicle Transport in Oligodendrocytes
    JORGE LAROCCA; Fiscal Year: 2006
    ..is involved in the transport of endosomal and lysosomal proteins from the TGN to the endosomes and whether myelin proteins are transported through this pathway before being targeted to myelin...
  16. Early intervention to restore OL and myelin development in leukodystrophy model
    Jean de Vellis; Fiscal Year: 2009
    ..shown that the ASPA knockout OLs exhibit lack of mature myelin basic proteins and lack of immunostaining of myelin proteins in cell processes in the CNS, even though presence of transcripts for myelin genes were identified...
  17. RECIPROCAL INTERACT - JVC T-ANTIGEN AND HOST REG FACTORS
    Kamel Khalili; Fiscal Year: 2003
    ..infect and destroy oligodendrocytes, a subclass of glial cells that is responsible for production of myelin proteins and myelin sheaths in brain...
  18. DEMYELINATION IN MULTIPLE SCLEROSIS
    MOON SHIN; Fiscal Year: 1999
    ..The TCC may cause splitting myelin lamellae and myelin vesiculation, since effective hydrolysis of structural myelin proteins such as MBP can be induced by TCC through activation of myelin proteases...
  19. IMMUNOREGULATION IN EAE--ROLE OF T CELL COSTIMULATION
    Samia Khoury; Fiscal Year: 2000
    ..disease of the central nervous system (CNS) that can be induced in a number of species by immunization with myelin proteins and adjuvant. The disease is initiated by antigen-specific encephalitogenic T cell activation...
  20. MYELIN PO PROTEIN--EXPRESSION/SORTING AND ADHESION
    Marie Filbin; Fiscal Year: 1992
    ..For the adhesion studies, cells that have no endogenous myelin proteins, Chinese hamster ovary (CHO) cells, will be used which will assist in the accurate interpretation of the data...
  21. MYELINATION--ASSEMBLY OF LIPIDS AND PROTEINS
    JOYCE BENJAMINS; Fiscal Year: 2003
    ..Changes in message levels for myelin proteins (MBP, PLP, and DDM-20), relevant transcription factors (SCIP, GtX, and CREB) and immediate early genes (zif , ..
  22. CARBONIC ANHYDRASE AND MYELIN DEVELOPMENT
    MARJORIE LEES; Fiscal Year: 1980
    ..Information on the possible induction of carbonic anhydrase, and other myelin proteins, by corticosteroids will be provided by a double isotope technique...
  23. Spinning Microlens Confocal Microscope
    William Mohler; Fiscal Year: 2004
    ..Steven Pfeiffer will study the dynamic transport of myelin proteins and their localization to lipid rafts via FRET...
  24. Regulation of Oligodendrocyte Survival
    Horea Rus; Fiscal Year: 2006
    ..that survive show the OLG progenitor-like phenotype: expression of protooncogenes and loss of mRNA encoding myelin proteins. C5b-9 induces DNA synthesis and enhances OLG survival...
  25. Ocular Regulation of Autoimmunity
    ROBERT CONE; Fiscal Year: 2009
    ..basic protein or myelin oligodendrocyte glycoprotein into an anterior chamber of mice immunized to these myelin proteins induces the production of antigen-specific regulatory T cells that suppress delayed- type hypersensitivity ..
  26. DEMYELINATING DISEASES
    ROBERT KIBLER; Fiscal Year: 1980
    ..dimers in myelin, and study its distribution in myelin density gradient fractions, 3) measure the turnover of myelin proteins in different myelin density gradient fractions, and 4) determine the structural relationships between myelin ..
  27. IN VIVO EFFECT OF DECREASED MYELIN CEREBROSIDE
    Sheldon Miller; Fiscal Year: 1993
    ..b>Myelin proteins and lipids are believed to be arranged in a manner coinciding with the fluid mosaic membrane model that ..
  28. THE TRAFFICKING OF MYELIN PROTEINS AND NEUROTROPHINS
    ERIC SHOOTER; Fiscal Year: 2003
    ..Overexpression of NT-3 in muscle will be achieved through mating of a transgenic myo-NT-3 with either a PMP22-deficient mouse or the or the Trembler-J mouse. ..
  29. Molecular Basis of the Demylinating Disorder ADLD
    Ying Hui Fu; Fiscal Year: 2003
    ..neuropathological findings suggest that the genesis of this disorder neither resides in defects of structural myelin proteins nor fatty acid metabolism in peroxisomes. ADLD is not an immune disease like multiple sclerosis (MS)...
  30. HYPOMYELINATED MUTANT AND DOUBLE MUTANT
    Merrill Wolf; Fiscal Year: 2000
    ..The MBP and PLP genes code, not only for major myelin proteins, but also for unknown developmental functions which may be carried out by alternately spliced isoforms of the ..
  31. GAP JUNCTIONS AND SCHWANN CELLS
    DAVID SPRAY; Fiscal Year: 2002
    ..a broadly based approach to the studies, taking advantage of recently developed animal models deficient in myelin proteins and making use of transfection technology in Schwann cells and cell lines. Specific Aim 1...
  32. GUILLIAN-BARRE SYNDROME AND ALLERGIC NEURITIS
    EDWARD EYLAR; Fiscal Year: 1980
    Our efforts are focused on the proteins of peripheral nerve myelin proteins. We are attempting to determine the complete amino acid sequence of the p2 protein from bovine, rabbit and human sources...
  33. AXONAL REGULATION OF MYELIN PROTEIN SYNTHESIS
    Kurt Brunden; Fiscal Year: 1993
    ..proposal are aimed at obtaining an understanding of the mechanism whereby axons trigger SCs to synthesize myelin proteins in the absence or presence of active myelination...
  34. MICROTUBULES AND MYELINATION IN A MUTANT RAT
    Ian Duncan; Fiscal Year: 2002
    ..of accumulation of microtubule in taiep oligodendrocyte, cultures of these cells will be immunolabelled for myelin proteins known to co-localize with the cytoskeleton, and myelin protein mRNAs will be localized by in situ ..
  35. CLONOTYPIC REGULATION OF ENCEPHALITOGENIC T LYMPHOCYTES
    Halina Offner; Fiscal Year: 2005
    ..b>myelin proteins, causing autoimmune diseases such as multiple sclerosis (MS)...
  36. MOLECULAR BIOLOGY OF CENTRAL NERVOUS SYSTEM MYELINATION
    Brian Popko; Fiscal Year: 1993
    ..The overall goal of our research is directed toward obtaining a better understanding of the role myelin proteins play in the myelination of the central nervous system (CNS)...
  37. STRUCTURE, METABOLISM & FUNCTION OF MYELIN PROTEINS
    RAYMOND SHAPIRA; Fiscal Year: 1980
    ..and comprehensive study of the structure, metabolism, function and encephalitogenic properties of the myelin proteins so as to achieve a better understanding of the role of myelin in normal and pathological states...
  38. MYELINATION AND DYSMYELINATION
    Ian Duncan; Fiscal Year: 1990
    ..Within the last five years, the genes for the major myelin proteins have been cloned and sequenced and the genetic basis for several of the myelin mutants has been identified...
  39. PLP Splicing: In Vivo Analysis in A Mouse Model
    Franca Cambi; Fiscal Year: 2004
    ..The production of PLP and other myelin proteins and myelin formation will be studied. The mouse phenotype will be characterized by motor testing...
  40. ETIOLOGY AND PATHOGENESIS OF MULTIPLE SCLEROSIS
    Hilary Koprowski; Fiscal Year: 1992
    ..and of the expression of myelin-associated biochemical properties, and the intracellular synthesis of myelin proteins and lipids will be studied...
  41. MECHANISMS OF NO-MEDIATED PROTEIN S-NITROSYLATION IN EAE
    OSCAR BIZZOZERO; Fiscal Year: 2007
    ..We propose that underlying this process is the S-nitrosylation of important myelin proteins by N203, a strong nitrosylating agent that can be readily formed by NO autooxidation in a lipid-rich ..
  42. NITRIC OXIDE, PLP ACYLATION & THE PATHOPHYSIOLOGY OF MS
    OSCAR BIZZOZERO; Fiscal Year: 2003
    ..abstract_text> ..
  43. A PHASE ll TRIAL OF RITUXAN IN MULTIPLE SCLEROSIS
    DOROTHY CROSS; Fiscal Year: 2007
    ..Parks and Naismith, and PI will be able to focus 30% more time on investigator-initiated trials and mentoring junior colleagues. ..
  44. THE ROLE OF B CELLS IN EAE PATHOGENESIS
    Anne Cross; Fiscal Year: 2004
    ..Methods to alter in humans the number and function of B cells and Abs already exist, making our results potentially applicable to MS therapy. ..
  45. EFFECTOR MOLECULES IN DEMYELINATING DISEASE
    Anne Cross; Fiscal Year: 2001
    ..Since there now have been identified pharmaceutic agents which can inhibit the production of PN, our findings from these studies may indicate an area with therapeutic potential for MS. ..
  46. Molecular Determinants of Adult CNS Axonal Growth
    Stephen M Strittmatter; Fiscal Year: 2010
    ..This work is critical to optimize the opportunity for development of clinical methods to increase axonal growth and improve functional recovery from neurological damage. ..
  47. Nogo Receptor Antagonist for Ischemic Stroke Recovery
    Stephen M Strittmatter; Fiscal Year: 2010
    ..Previous work has indicated that CNS myelin proteins play a role in limiting the degree of axonal regeneration after traumatic transection in the spinal cord...
  48. Nogo Receptor in Adult Central Nervous System Plasticity and Regeneration
    Stephen M Strittmatter; Fiscal Year: 2010
    ..Such data will inform our understanding of the stability of connectivity within the CNS and illuminate the possibility of harnessing this knowledge for therapeutic interventions. ..
  49. AXONAL GROWTH CONE SIGNAL TRANSDUCTION
    Stephen Strittmatter; Fiscal Year: 2004
    ....
  50. Functional Organization of the Myelin Membrane
    Christopher Taylor; Fiscal Year: 2003
    The specific aims of this proposal are to 1) establish a two-dimensional (2D) proteomic map of myelin proteins using high-resolution 2D gel electrophoresis, Western blotting, mass spectrometry, and bioinformatics, 2) establish a 2D ..
  51. ESTROGEN EFFICACY IN SPINAL CORD INJURY
    Naren Banik; Fiscal Year: 2006
    ..Understanding estrogen's mechanisms in cell protection and recovery as it relates to multidestructive pathways will establish it as a viable SCI treatment agent. ..
  52. Conference on Axonal Connections
    Stephen Strittmatter; Fiscal Year: 2005
    ..Topics will include basic research on molecular cues, and resulting new approaches toward therapeutic axon repair. ..
  53. Targeting Pathways of Axonal Cell Adhesion Molecules
    Bettina Winckler; Fiscal Year: 2007
    ..The overall goal of our work is to specify the mechanisms producing the polarized architecture of neurons. [unreadable] [unreadable]..
  54. CALPAIN IN THE PATHOPHYSIOLOGY OF DEMYELINATING DISEASE
    Naren Banik; Fiscal Year: 2003
    ....
  55. PROTEOMIC MAPPING OF MYELIN AND ITS MEMBRANE SUBDOMAINS
    Rashmi Bansal; Fiscal Year: 2009
    ..active biological functions of myelin is to identify and characterize functionally the complete repertoire of myelin proteins, i.e., the Myelin Proteome...
  56. CALPAIN ACTIVATION OF T CELLS IN DEMYELINATING DISEASE
    Naren Banik; Fiscal Year: 2009
    ..Understanding the mechanisms may help develop therapeutic strategies (e.g., calpain as a target) for treatment of MS. ..
  57. Attenuation of Axonal Damage and Neuronal Death in EAE
    Naren L Banik; Fiscal Year: 2010
    ..abstract_text> ..
  58. Adaptive rewiring of the mature brain after injury
    Larry Benowitz; Fiscal Year: 2008
    ..These studies will increase our understanding of plasticity in the mature brain and potentially enable us to improve functional outcome after injury. ..
  59. Retrocyclins: Cyclic mini-defensins that inactivate anthrax toxins
    ROBERT IRVING contact LEHRER; Fiscal Year: 2010
    ..anthracis spores in mouse models as per the revised Specific Aims. All remaining Aims can be addressed in a two-year time period. PHS ..
  60. Summer Training Program in Neuroscience
    Oswald Steward; Fiscal Year: 2006
    ..Where appropriate, trainees will be encouraged to present their results at national meetings, and support will be provided for students to attend such meetings. [unreadable] [unreadable]..