virus receptors

Summary

Summary: Specific molecular components of the cell capable of recognizing and interacting with a virus, and which, after binding it, are capable of generating some signal that initiates the chain of events leading to the biological response.

Top Publications

  1. ncbi HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5
    T Dragic
    The Aaron Diamond AIDS Research Center, The Rockefeller University, New York 10016, USA
    Nature 381:667-73. 1996
  2. pmc DC-SIGN (CD209) mediates dengue virus infection of human dendritic cells
    Boonrat Tassaneetrithep
    Division of Retrovirology, Walter Reed Army Institite of Research and Henry M Jackson Foundation for the Advancement of Military Medicine Diseases, Rockville, MD 20850, USA
    J Exp Med 197:823-9. 2003
  3. pmc The human scavenger receptor class B type I is a novel candidate receptor for the hepatitis C virus
    Elisa Scarselli
    Istituto di Ricerche di Biologia Molecolare P Angeletti IRBM, Via Pontina Km 30 600, 00040 Pomezia Rome, Italy
    EMBO J 21:5017-25. 2002
  4. ncbi The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity
    Chen Zhu
    Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Immunol 6:1245-52. 2005
  5. ncbi Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease
    Laurent Monney
    Center for Neurologic Diseases, Department of Neurology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 415:536-41. 2002
  6. ncbi Dengue virus infectivity depends on envelope protein binding to target cell heparan sulfate
    Y Chen
    Department of Internal Medicine, University of Michigan, Ann Arbor 48109, USA
    Nat Med 3:866-71. 1997
  7. ncbi Virus entry: open sesame
    Mark Marsh
    Cell Biology Unit, MRC Laboratory for Molecular Cell Biology, and Department of Biochemistry and Molecular Biology, University College London, Gower Street, London WC1E 6BT, United Kingdom
    Cell 124:729-40. 2006
  8. pmc CD81 is required for hepatitis C virus glycoprotein-mediated viral infection
    Jie Zhang
    Center for the Study of Hepatitis C, Laboratory of Virology and Infectious Diseases, The Rockefeller University, New York, New York 10021, USA
    J Virol 78:1448-55. 2004
  9. pmc CD81 and claudin 1 coreceptor association: role in hepatitis C virus entry
    Helen J Harris
    University of Birmingham, Division of Infection and Immunity, Institute for Biomedical Research, Vincent Dr, Birmingham B15 2TT, United Kingdom
    J Virol 82:5007-20. 2008
  10. ncbi Avian flu: influenza virus receptors in the human airway
    Kyoko Shinya
    Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    Nature 440:435-6. 2006

Research Grants

  1. Mechanisms of cytokine-mediated viral clearance from neurons
    LAUREN ALENE O apos DONNELL; Fiscal Year: 2010
  2. Entry and Pathogenesis of Coronaviruses
    THOMAS MILLER GALLAGHER; Fiscal Year: 2011
  3. High-Expression, Rapid Production of Influenza Vaccines in Cell-Based Systems
    Vitaliy Gavrilyuk; Fiscal Year: 2013
  4. LDV-INDUCED GENETICALLY RESTRICTED CNS DISEASE
    MARGO BRINTON; Fiscal Year: 1991
  5. CELL SURFACE PROTEINS INVOLVED IN ECHOVIRUS ATTACHMENT
    Robert Finberg; Fiscal Year: 1999
  6. Measles virus receptors in the cotton rat model
    Stefan Niewiesk; Fiscal Year: 2006
  7. THE BACTERIAL SURFACE AND ITS MULTIFUNCTIONAL DOMAINS
    Manfred Bayer; Fiscal Year: 1990
  8. Broadly Inhibitory MAbs Targeting Hepatitis C Virus Receptors
    Sofija Andjelic; Fiscal Year: 2007
  9. TOGAVIRUS REPLICATION STRATEGIES AND EVOLUTION
    James Strauss; Fiscal Year: 2004
  10. Molecular Mechanisms of Systemic Adenovirus Toxicity
    Dmitry Shayakhmetov; Fiscal Year: 2004

Detail Information

Publications262 found, 100 shown here

  1. ncbi HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5
    T Dragic
    The Aaron Diamond AIDS Research Center, The Rockefeller University, New York 10016, USA
    Nature 381:667-73. 1996
    ..CC-CKR-5 is a second receptor for NSI primary viruses...
  2. pmc DC-SIGN (CD209) mediates dengue virus infection of human dendritic cells
    Boonrat Tassaneetrithep
    Division of Retrovirology, Walter Reed Army Institite of Research and Henry M Jackson Foundation for the Advancement of Military Medicine Diseases, Rockville, MD 20850, USA
    J Exp Med 197:823-9. 2003
    ..Viruses produced by dendritic cells are infectious for DC-SIGN- and L-SIGN-bearing THP-1 cells and other permissive cell lines. Therefore, DC-SIGN may be considered as a new target for designing therapies that block dengue infection...
  3. pmc The human scavenger receptor class B type I is a novel candidate receptor for the hepatitis C virus
    Elisa Scarselli
    Istituto di Ricerche di Biologia Molecolare P Angeletti IRBM, Via Pontina Km 30 600, 00040 Pomezia Rome, Italy
    EMBO J 21:5017-25. 2002
    ..Finally, E2 recognition by SR-BI was competed out in an isolate-specific manner both on the hepatoma cell line and on the human SR-BI-transfected cell line by an anti-HVR1 monoclonal antibody...
  4. ncbi The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity
    Chen Zhu
    Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Immunol 6:1245-52. 2005
    ..These data suggest that the Tim-3-galectin-9 pathway may have evolved to ensure effective termination of effector T(H)1 cells...
  5. ncbi Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease
    Laurent Monney
    Center for Neurologic Diseases, Department of Neurology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 415:536-41. 2002
    ..Tim-3 may have an important role in the induction of autoimmune diseases by regulating macrophage activation and/or function...
  6. ncbi Dengue virus infectivity depends on envelope protein binding to target cell heparan sulfate
    Y Chen
    Department of Internal Medicine, University of Michigan, Ann Arbor 48109, USA
    Nat Med 3:866-71. 1997
    ..Similar motifs were also identified in the envelope proteins of other flaviviridae. Developing pharmaceuticals that inhibit target cell binding may be an effective strategy for treating flavivirus infections...
  7. ncbi Virus entry: open sesame
    Mark Marsh
    Cell Biology Unit, MRC Laboratory for Molecular Cell Biology, and Department of Biochemistry and Molecular Biology, University College London, Gower Street, London WC1E 6BT, United Kingdom
    Cell 124:729-40. 2006
    ..In addition, such insights reveal new targets for attacking viruses before they can usurp the host-cell machinery for replication...
  8. pmc CD81 is required for hepatitis C virus glycoprotein-mediated viral infection
    Jie Zhang
    Center for the Study of Hepatitis C, Laboratory of Virology and Infectious Diseases, The Rockefeller University, New York, New York 10021, USA
    J Virol 78:1448-55. 2004
    ..These data suggest a functional role for CD81 as a coreceptor for HCV glycoprotein-dependent viral cell entry...
  9. pmc CD81 and claudin 1 coreceptor association: role in hepatitis C virus entry
    Helen J Harris
    University of Birmingham, Division of Infection and Immunity, Institute for Biomedical Research, Vincent Dr, Birmingham B15 2TT, United Kingdom
    J Virol 82:5007-20. 2008
    ....
  10. ncbi Avian flu: influenza virus receptors in the human airway
    Kyoko Shinya
    Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    Nature 440:435-6. 2006
    ..Our findings may provide a rational explanation for why H5N1 viruses at present rarely infect and spread between humans although they can replicate efficiently in the lungs...
  11. pmc Identification of conserved residues in the E2 envelope glycoprotein of the hepatitis C virus that are critical for CD81 binding
    Ania M Owsianka
    MRC Virology Unit, Institute of Virology, University of Glasgow, UK
    J Virol 80:8695-704. 2006
    ..Specific amino acids conserved across all genotypes that were critical for CD81 binding were W420, Y527, W529, G530, and D535. These data significantly increase our understanding of the CD81 receptor-E2 binding process...
  12. ncbi Tim-3 inhibits T helper type 1-mediated auto- and alloimmune responses and promotes immunological tolerance
    Alberto Sanchez-Fueyo
    Division of Immunology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Nat Immunol 4:1093-101. 2003
    ..Our data indicate that the Tim-3 pathway provides an important mechanism to down-regulate T(H)1-dependent immune responses and to facilitate the development of immunological tolerance...
  13. pmc The coxsackievirus and adenovirus receptor is a transmembrane component of the tight junction
    C J Cohen
    Division of Immunologic and Infectious Diseases, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 98:15191-6. 2001
    ..These results indicate that CAR is a component of the tight junction and of the functional barrier to paracellular solute movement. Sequestration of CAR in tight junctions may limit virus infection across epithelial surfaces...
  14. ncbi Interaction of Tim-3 and Tim-3 ligand regulates T helper type 1 responses and induction of peripheral tolerance
    Catherine A Sabatos
    Department of Neurology, Center for Neurologic Diseases, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Immunol 4:1102-10. 2003
    ..These data indicate that interaction of Tim-3 with Tim-3 ligand may serve to inhibit effector T(H)1 cells during a normal immune response and may be crucial for the induction of peripheral tolerance...
  15. ncbi Claudin-1 is a hepatitis C virus co-receptor required for a late step in entry
    Matthew J Evans
    Center for the Study of Hepatitis C, The Rockefeller University, 1230 York Ave, New York 10021, USA
    Nature 446:801-5. 2007
    ..With CLDN1 we have identified a novel key factor for HCV entry and a new target for antiviral drug development...
  16. ncbi The human CD46 molecule is a receptor for measles virus (Edmonston strain)
    R E Dörig
    Biotechnology Research Institute, National Research Council of Canada, Montreal, Quebec
    Cell 75:295-305. 1993
    ..Finally, polyclonal antisera against CD46 inhibited virus binding and infection. These results prove that human CD46 permits cells both to bind measles virus and to support infection...
  17. pmc Cell-surface receptors for gibbon ape leukemia virus and amphotropic murine retrovirus are inducible sodium-dependent phosphate symporters
    M P Kavanaugh
    Vollum Institute for Advanced Biomedical Research, Oregon Health Sciences University, Portland 97201
    Proc Natl Acad Sci U S A 91:7071-5. 1994
    ..Accordingly, depletion of extracellular phosphate increased Ram-1 and Glvr-1 expression 3- to 5-fold. These results suggest simple methods to modulate retroviral receptor expression, with possible applications to human gene therapy...
  18. pmc Foot-and-mouth disease virus receptors: comparison of bovine alpha(V) integrin utilization by type A and O viruses
    Hernando Duque
    Foot and Mouth Disease Research Unit, United States Department of Agriculture, Agricultural Research Service, Plum Island Animal Disease Center, Greenport, NY 11944 0848, USA
    J Virol 77:2500-11. 2003
    ..Thus, the ability of the virus to utilize multiple integrins in vitro may be a reflection of the use of multiple receptors during the course of infection within the susceptible host...
  19. pmc Species and age related differences in the type and distribution of influenza virus receptors in different tissues of chickens, ducks and turkeys
    Smitha P S Pillai
    Food Animal Health Research Program, Ohio Agricultural Research and Development Center, The Ohio State University, Wooster, Ohio 44691, USA
    Virol J 7:5. 2010
    ....
  20. pmc Roles for endocytosis and low pH in herpes simplex virus entry into HeLa and Chinese hamster ovary cells
    Anthony V Nicola
    Medical Virology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Virol 77:5324-32. 2003
    ..The results suggest that HSV can utilize two distinct entry pathways, depending on the type of cell encountered...
  21. pmc HCAR and MCAR: the human and mouse cellular receptors for subgroup C adenoviruses and group B coxsackieviruses
    R P Tomko
    Skirball Institute of Biomolecular Medicine, New York University Medical Center, NY 10016, USA
    Proc Natl Acad Sci U S A 94:3352-6. 1997
    ..Taken together, these results confirm that the isolated cDNAs encode the receptors for the subgroup C Ad and CVB...
  22. ncbi Isolation of a common receptor for Coxsackie B viruses and adenoviruses 2 and 5
    J M Bergelson
    Division of Infectious Diseases, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Science 275:1320-3. 1997
    ..Identification of CAR as a receptor for these two unrelated and structurally distinct viral pathogens is important for understanding viral pathogenesis and has implications for therapeutic gene delivery with adenovirus vectors...
  23. pmc Gangliosides are receptors for murine polyoma virus and SV40
    Billy Tsai
    Howard Hughes Medical Institute and Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA
    EMBO J 22:4346-55. 2003
    ..Lipid binding sites for polyoma are shown to be present in rough ER membranes, suggesting that the virus travel with the ganglioside(s) from the plasma membranes to the ER...
  24. ncbi Cellular receptor for poliovirus: molecular cloning, nucleotide sequence, and expression of a new member of the immunoglobulin superfamily
    C L Mendelsohn
    Department of Microbiology, Columbia University College of Physicians and Surgeons, New York, New York 10032
    Cell 56:855-65. 1989
    ....
  25. pmc Cloning and characterization of a cell surface receptor for xenotropic and polytropic murine leukemia viruses
    C S Tailor
    Department of Biochemistry and Molecular Biology, Oregon Health Sciences University, Portland, OR 97201 3098, USA
    Proc Natl Acad Sci U S A 96:927-32. 1999
    ..We propose that X-MLVs and P-MLVs comprise a single family of retroviruses that have coevolved in response to diversification in X-receptor genes of the host...
  26. ncbi Promotion of tissue inflammation by the immune receptor Tim-3 expressed on innate immune cells
    Ana C Anderson
    Division of Molecular Immunology, Center for Neurologic Diseases, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Science 318:1141-3. 2007
    ..Thus, by virtue of differential expression on innate versus adaptive immune cells, Tim-3 can either promote or terminate TH1 immunity and may be able to influence a range of inflammatory conditions...
  27. pmc Dysregulated T cell expression of TIM3 in multiple sclerosis
    Ken Koguchi
    Center for Neurologic Diseases, Department of Neurology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Exp Med 203:1413-8. 2006
    ..Failure to up-regulate T cell expression of TIM3 in inflammatory sites may represent a novel, intrinsic defect that contributes to the pathogenesis of MS and other human autoimmune diseases...
  28. ncbi Functional analysis of hepatitis C virus E2 glycoproteins and virus-like particles reveals structural dissimilarities between different forms of E2
    A Owsianka
    MRC Virology Unit, Institute of Virology, Church Street, Glasgow G11 5JR, UK
    J Gen Virol 82:1877-83. 2001
    ..These findings underscore the need to carefully select an appropriate ligand for structure-function analysis...
  29. pmc The alpha/beta interferon response controls tissue tropism and pathogenicity of poliovirus
    Miki Ida-Hosonuma
    Department of Microbiology and Immunology, Tokyo Metropolitan Institute for Neuroscience, Tokyo Metropolitan Organization for Medical Research, Tokyo 183 8526, Japan
    J Virol 79:4460-9. 2005
    ..We consider that poliovirus replication was observed in the nontarget tissues of PVR-transgenic/Ifnar knockout mice because the IFN response was null in all tissues...
  30. ncbi Cell entry of hepatitis C virus requires a set of co-receptors that include the CD81 tetraspanin and the SR-B1 scavenger receptor
    Birke Bartosch
    Laboratoire de Vectorologie Rétrovirale et Thérapie Génique, INSERM U412, Institut Fédératif de Recherche 128, Ecole Normale Superieure de Lyon, 46 allee d Italie, 69364 Lyon Cedex 07, France
    J Biol Chem 278:41624-30. 2003
    ..Finally, by correlating expression of HCV receptors and infectivity, we suggest that, besides CD81 and SR-B1, additional hepatocyte-specific co-factor(s) are necessary for HCV entry...
  31. ncbi Evolution of the receptor binding phenotype of influenza A (H5) viruses
    Alexandra Gambaryan
    Chumakov Institute of Poliomyelitis and Viral Encephalitides, Russian Academy of Medical Sciences, 142782 Moscow, Russia
    Virology 344:432-8. 2006
    ..These data demonstrate that the genetic evolution of avian influenza A(H5N1) viruses is accompanied during adaptation to poultry by the evolution of their receptor specificity...
  32. ncbi Receptors for polytropic and xenotropic mouse leukaemia viruses encoded by a single gene at Rmc1
    Y L Yang
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Genet 21:216-9. 1999
    ..We also obtained the cDNA encoding human SYG1. When expressed in hamster cells, it establishes infectivity by MCF MLV as well as xenotropic MLV, which do not infect laboratory mice...
  33. pmc Glycoprotein D receptor-dependent, low-pH-independent endocytic entry of herpes simplex virus type 1
    Richard S B Milne
    Department of Microbiology, University of Pennsylvania, School of Dental Medicine, 215 Levy Building, 240 South 40th Street, Philadelphia, PA 19104 6002, USA
    J Virol 79:6655-63. 2005
    ..Resistance to similar reagents should therefore not be taken as proof of HSV entry by a nonendosomal pathway. These data define a novel gD receptor-dependent acid-independent endocytic entry pathway for HSV...
  34. pmc Nectin2alpha (PRR2alpha or HveB) and nectin2delta are low-efficiency mediators for entry of herpes simplex virus mutants carrying the Leu25Pro substitution in glycoprotein D
    M Lopez
    Institute of Cancerology and Immunology, INSERM U119, Marseille, France
    J Virol 74:1267-74. 2000
    ..Binding of wt HSV-1 gD to soluble nectin2 was not detectable. (iv) A major region of nectin2 functional in virus entry mapped to the V domain, located at the N terminus...
  35. ncbi Measles virus receptors
    Y Yanagi
    Department of Virology, Faculty of Medicine, Kyushu University, 812 8582, Fukuoka, Japan
    Curr Top Microbiol Immunol 329:13-30. 2009
    ..Other molecules have also been implicated in MV infection, although their relevance remains to be determined. The identification of MV receptors has advanced our understanding of MV tropism and pathogenesis...
  36. pmc The tight junction proteins claudin-1, -6, and -9 are entry cofactors for hepatitis C virus
    Laurent Meertens
    Albert Einstein College of Medicine, Department of Microbiology and Immunology, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    J Virol 82:3555-60. 2008
    ..Our work has generated novel and essential means to investigate the mechanism of HCV penetration into hepatocytes and the role of the claudin protein family in HCV dissemination, replication, and pathogenesis...
  37. pmc Early alterations of the receptor-binding properties of H1, H2, and H3 avian influenza virus hemagglutinins after their introduction into mammals
    M Matrosovich
    Department of Virology and Molecular Biology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, Russia
    J Virol 74:8502-12. 2000
    ....
  38. pmc Hepatitis C virus glycoproteins mediate pH-dependent cell entry of pseudotyped retroviral particles
    Mayla Hsu
    Aaron Diamond AIDS Research Center and Center for the Study of Hepatitis C, Laboratory of Virology and Infectious Disease, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 100:7271-6. 2003
    ..However, HIV-HCV pseudotype infectivity was inhibited by a recombinant soluble form of CD81 and a mAb specific for CD81, suggesting that CD81 may be a component of a receptor complex...
  39. pmc Receptors and entry cofactors for retroviruses include single and multiple transmembrane-spanning proteins as well as newly described glycophosphatidylinositol-anchored and secreted proteins
    J Overbaugh
    Division of Human Biology, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave, Seattle, WA 98109 1024, USA
    Microbiol Mol Biol Rev 65:371-89, table of contents. 2001
    ..In this review, we will focus on the various strategies used by mammalian retroviruses to gain entry into the cell. The choice of receptors will also be discussed in light of pressures that drive viral evolution and persistence...
  40. ncbi SLAM (CDw150) is a cellular receptor for measles virus
    H Tatsuo
    Department of Virology, Faculty of Medicine, Kyushu University, Fukuoka, Japan
    Nature 406:893-7. 2000
    ..The identification of SLAM as a receptor for measles virus opens the way to a better understanding of the pathogenesis of measles virus infection, especially the immunosuppression induced by measles virus...
  41. ncbi Expression cloning of the STRL33/BONZO/TYMSTRligand reveals elements of CC, CXC, and CX3C chemokines
    A Wilbanks
    Millennium Pharmaceuticals, Cambridge, MA 02139, USA
    J Immunol 166:5145-54. 2001
    ..Additionally, this chemokine might play a unique dual role of attracting activated lymphocyte subsets during inflammation as well as facilitating immune responses via cell-cell contact...
  42. ncbi The CD4 (T4) antigen is an essential component of the receptor for the AIDS retrovirus
    A G Dalgleish
    Nature 312:763-7. 1984
    ..Hence, we conclude that the CD4 antigen is an essential and specific component of the receptor for the causative agent of AIDS...
  43. ncbi The coxsackie- and adenovirus receptor (CAR) is an in vivo marker for epithelial tight junctions, with a potential role in regulating permeability and tissue homeostasis
    Elisabeth Raschperger
    Ludwig Institute for Cancer Research, Nobels v 3, SE 171 77 Stockholm, Sweden
    Exp Cell Res 312:1566-80. 2006
    ..We conclude that CAR is localized to epithelial tight junctions in vivo where it may play a role in the regulation of epithelial permeability and tissue homeostasis...
  44. ncbi Use of CD134 as a primary receptor by the feline immunodeficiency virus
    Masayuki Shimojima
    Department of Veterinary Microbiology, Graduate School of Agricultural and Life Sciences, University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    Science 303:1192-5. 2004
    ..Thus, despite the evolutionary divergence of the feline and human lentiviruses, both viruses use receptors that target the virus to a subset of cells that are pivotal to the acquired immune response...
  45. ncbi Cell fusion induced by herpes simplex virus glycoproteins gB, gD, and gH-gL requires a gD receptor but not necessarily heparan sulfate
    P E Pertel
    Department of Medicine, Northwestern University Medical School, Chicago, Illinois, 60611, USA
    Virology 279:313-24. 2001
    ..Overall, the viral and cellular determinants of HSV-1-induced cell fusion are similar to those for viral entry, except that HSV-1 entry is significantly enhanced by binding of virus to cell surface heparan sulfate...
  46. ncbi Structural analysis of the mechanism of adenovirus binding to its human cellular receptor, CAR
    M C Bewley
    Biology Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Science 286:1579-83. 1999
    ..The structure identifies key determinants of binding specificity, which may suggest ways to modify the tropism of adenovirus-based gene therapy vectors...
  47. ncbi A two-amino acid change in the hemagglutinin of the 1918 influenza virus abolishes transmission
    Terrence M Tumpey
    Influenza Branch, Mailstop G 16, Division of Viral and Ricksettial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road NE, Atlanta, GA 30333, USA
    Science 315:655-9. 2007
    ..These findings confirm an essential role of hemagglutinin receptor specificity for the transmission of influenza viruses among mammals...
  48. pmc A single amino acid substitution in 1918 influenza virus hemagglutinin changes receptor binding specificity
    Laurel Glaser
    Department of Microbiology, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Virol 79:11533-6. 2005
    ..Mutation of this single amino acid back to the avian consensus resulted in a preference for the avian receptor...
  49. ncbi The TIM gene family: emerging roles in immunity and disease
    Vijay K Kuchroo
    Center for Neurologic Diseases, Brigham and Women s Hospital, Dana Farber Cancer Institute, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA
    Nat Rev Immunol 3:454-62. 2003
    ..Here, we describe the various TIM-family members in mice and humans, and discuss the genetic and functional evidence for their role in regulating autoimmune and allergic diseases...
  50. pmc CXCR6 induces prostate cancer progression by the AKT/mammalian target of rapamycin signaling pathway
    Jianhua Wang
    Shanghai Jiao Tong University School of Medicine, Institute of Medical Sciences, Shanghai, PR China
    Cancer Res 68:10367-76. 2008
    ..Blocking the CXCR6/AKT/mTOR signaling pathway may prove beneficial to prevent metastasis and provide a more effective therapeutic strategy for PCa...
  51. pmc Capsid region involved in hepatitis A virus binding to glycophorin A of the erythrocyte membrane
    Gloria Sanchez
    Department of Microbiology, University of Barcelona, Av Diagonal 645, 08028 Barcelona, Spain
    J Virol 78:9807-13. 2004
    ....
  52. ncbi Haemagglutinin mutations responsible for the binding of H5N1 influenza A viruses to human-type receptors
    Shinya Yamada
    Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo 108 8639, Japan
    Nature 444:378-82. 2006
    ..The amino acid changes that we identify might serve as molecular markers for assessing the pandemic potential of H5N1 field isolates...
  53. ncbi The human poliovirus receptor related 2 protein is a new hematopoietic/endothelial homophilic adhesion molecule
    M Lopez
    INSERM U 119, Unité de Cancérologie et Thérapeutique Expérimentales, Marseille, France
    Blood 92:4602-11. 1998
    ..Altogether, these results suggest that homophilic properties of PRR2 could participate to the regulation of hematopoietic/endothelial cell functions...
  54. ncbi Internalization and trafficking mechanisms of coxsackievirus B3 in HeLa cells
    Sun Ku Chung
    Department of Biomedical Sciences, National Institute of Health, 5 Nokbun dong, Eunpyung Gu, Seoul, 122 701 Korea
    Virology 333:31-40. 2005
    ..In conclusion, these data together indicate that CVB3 uses clathrin-mediated endocytosis and is transcytosed to early endosomes...
  55. ncbi Herpes simplex virus-1 entry into cells mediated by a novel member of the TNF/NGF receptor family
    R I Montgomery
    Northwestern University Medical School, Department of Microbiology Immunology, Chicago, Illinois 60611, USA
    Cell 87:427-36. 1996
    ..The contribution of HVEM to HSV entry into human cells was demonstrable in activated T cells. HVEM, the first identified mediator of HSV entry, is a new member of the TNF/NGF receptor family...
  56. pmc Human herpesvirus 8 envelope glycoprotein K8.1A interaction with the target cells involves heparan sulfate
    F Z Wang
    Department of Microbiology, Molecular Genetics, and Immunology, The University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    J Virol 75:7517-27. 2001
    ..These findings suggest that gpK8.1A interaction with target cells involves cell surface HS-like moieties, and HHV-8 interaction with HS could be in part mediated by virion envelope-associated gpK8.1A...
  57. pmc Cellular integrins function as entry receptors for human cytomegalovirus via a highly conserved disintegrin-like domain
    Adam L Feire
    McArdle Laboratory for Cancer Research, University of Wisconsin, Madison, WI 53706, USA
    Proc Natl Acad Sci U S A 101:15470-5. 2004
    ..Strikingly, the glycoprotein B disintegrin-like domain is conserved in many human and animal herpesviruses, suggesting that integrins may support entry across this medically important virus family...
  58. ncbi Integrin alpha(v)beta3 (vitronectin receptor) is a candidate receptor for the virulent echovirus 9 strain Barty
    B Nelsen-Salz
    Institut fur Virologie der Universitat zu Koln, Germany
    J Gen Virol 80:2311-3. 1999
    ....
  59. ncbi Rabies virus receptors
    Monique Lafon
    Unité de Neuroimmunologie Virale, Département de Neuroscience, Institut Pasteur, 75724 Paris Cedex 15, France
    J Neurovirol 11:82-7. 2005
    ..However, little is known of the role of these molecules in vivo. This review proposes a speculative model that accounts for the role of these different molecules in entry and trafficking of rabies virus into the nervous system...
  60. pmc Hepatitis C virus and other flaviviridae viruses enter cells via low density lipoprotein receptor
    V Agnello
    Lahey Clinic Medical Center, Department of Laboratory Medicine, Burlington, MA 01805, USA
    Proc Natl Acad Sci U S A 96:12766-71. 1999
    ..These findings provide evidence that the family of LDL receptors may serve as viral receptors...
  61. ncbi New roles for TIM family members in immune regulation
    Vijay K Kuchroo
    Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA
    Nat Rev Immunol 8:577-80. 2008
    ..However, the recent discovery that antigen-presenting cells also express TIM molecules and the identification of new TIM-protein ligands has expanded the known roles of the TIM proteins in immune regulation...
  62. pmc Bottleneck-mediated quasispecies restriction during spread of an RNA virus from inoculation site to brain
    Julie K Pfeiffer
    Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 103:5520-5. 2006
    ..We suggest that the innate immune response can limit viral pathogenicity by limiting the number and therefore the diversity of viruses during spread to vulnerable tissues...
  63. ncbi Murine endogenous retroviruses
    C Stocking
    Heinrich Pette Institute, Hamburg, Germany
    Cell Mol Life Sci 65:3383-98. 2008
    ..We review mechanisms by which an adaptive coexistence has evolved. (Part of a multi-author review)...
  64. pmc The first immunoglobulin-like domain of HveC is sufficient to bind herpes simplex virus gD with full affinity, while the third domain is involved in oligomerization of HveC
    C Krummenacher
    Department of Microbiology, School of Dental Medicine, Philadelphia, Pennsylvania 19104, USA
    J Virol 73:8127-37. 1999
    ..In addition, the stoichiometry between gD and HveC appeared to be influenced by the level of HveC oligomerization...
  65. pmc Fungal phosphate transporter serves as a receptor backbone for gibbon ape leukemia virus
    L Pedersen
    Department of Molecular and Structural Biology, University of Aarhus, Aarhus C, Denmark
    J Virol 71:7619-22. 1997
    ..Therefore, the presence of a Pit1 loop 4-specific sequence is sufficient to confer receptor function for the mammalian retrovirus GALV on the fungal phosphate transporter Pho-4...
  66. ncbi Extended plasma circulation time and decreased toxicity of polymer-coated adenovirus
    N K Green
    Hybrid Systems Ltd, Oxford BioBusiness Centre, Littlemore Park, Littlemore, Oxford, UK
    Gene Ther 11:1256-63. 2004
    ..Such an increase in the bioavailability of adenovirus, coupled with substantial decreases in toxicity and unwanted transgene expression is an important step towards producing systemically available tumour-targeted viruses...
  67. ncbi Inhibition of the Raf/MEK/ERK pathway up-regulates expression of the coxsackievirus and adenovirus receptor in cancer cells
    Mario Anders
    Cancer Research Institute, University of California, San Francisco 94143, USA
    Cancer Res 63:2088-95. 2003
    ....
  68. pmc Two key residues in ephrinB3 are critical for its use as an alternative receptor for Nipah virus
    Oscar A Negrete
    Department of Microbiology, Immunology and Molecular Genetics, David Geffen School of Medicine, University of California Los Angeles, California, USA
    PLoS Pathog 2:e7. 2006
    ..Thus, ephrinB3 is a bona fide alternate receptor for NiV entry, and two residues in the G-H loop of the ephrin B-class ligands are critical determinants of NiV receptor activity...
  69. ncbi The Coxsackievirus and adenovirus receptor (CAR) forms a complex with the PDZ domain-containing protein ligand-of-numb protein-X (LNX)
    Kerstin Sollerbrant
    Ludwig Institute for Cancer Research, Stockholm Branch, Karolinska Intitutet, SE 17177 Stockholm, Sweden
    J Biol Chem 278:7439-44. 2003
    ..CAR and LNX were also shown to colocalize in vivo in mammalian cells. We speculate that CAR and LNX are part of a larger protein complex that might have important functions at discrete subcellular localizations in the cell...
  70. pmc A dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin (DC-SIGN)-related protein is highly expressed on human liver sinusoidal endothelial cells and promotes HIV-1 infection
    A A Bashirova
    Laboratory of Genomic Diversity, Science Applications International Corporation Frederick, Frederick, MD 21702, USA
    J Exp Med 193:671-8. 2001
    ..We propose that L-SIGN may play an important role in the interaction between liver sinusoidal endothelium and trafficking lymphocytes, as well as function in the pathogenesis of HIV-1...
  71. pmc Entry of herpes simplex virus mediated by chimeric forms of nectin1 retargeted to endosomes or to lipid rafts occurs through acidic endosomes
    Tatiana Gianni
    Section on Microbiology and Virology, Department of Experimental Pathology, University of Bologna, Via San Giacomo 12, 40126 Bologna, Italy
    J Virol 78:12268-76. 2004
    ..iii) Structural features of the receptors are additional determinants that control whether HSV entry occurs at the plasma membrane or at endosomes. These findings are relevant to studies of HSV retargeting to specific receptors...
  72. pmc Mutations in the N termini of herpes simplex virus type 1 and 2 gDs alter functional interactions with the entry/fusion receptors HVEM, nectin-2, and 3-O-sulfated heparan sulfate but not with nectin-1
    Miri Yoon
    Department of Microbiology Immunology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    J Virol 77:9221-31. 2003
    ..The sequence of the N terminus determines whether nectin-2 or 3-O-sulfated heparan sulfate, as well as HVEM, can serve as entry/fusion receptors...
  73. ncbi Functional balance between haemagglutinin and neuraminidase in influenza virus infections
    Ralf Wagner
    Institut fur Virologie, Philipps Universitat, 35011 Marburg, Germany
    Rev Med Virol 12:159-66. 2002
    ..The resulting decrease in the viral replicative fitness is usually overcome by restoration of the functional balance due to compensatory mutations in HA, NA or both proteins...
  74. ncbi The novel receptors that mediate the entry of herpes simplex viruses and animal alphaherpesviruses into cells
    G Campadelli-Fiume
    Department of Experimental Pathology, Section on Microbiology and Virology, University of Bologna, Via San Giacomo 12, 40126 Bologna, Italy
    Rev Med Virol 10:305-19. 2000
    ..This provides the first example of a mediator of HSV entry independent of a detectable interaction with gD...
  75. ncbi Development of an adenoviral vector system with adenovirus serotype 35 tropism; efficient transient gene transfer into primary malignant hematopoietic cells
    Marcus Nilsson
    Department of Molecular Medicine and Gene Therapy, Lund University, SE 22184 Lund, Sweden
    J Gene Med 6:631-41. 2004
    ..Fiber-retargeted adenoviral vectors with species B tropism can potentially bypass the CAR requirement and facilitate efficient gene transfer into malignant hematopoietic cells...
  76. pmc Localization of a binding site for herpes simplex virus glycoprotein D on herpesvirus entry mediator C by using antireceptor monoclonal antibodies
    C Krummenacher
    Department of Microbiology, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Virol 74:10863-72. 2000
    ..302 (conformational epitopes) to HveC and vice versa. Epitope mapping showed that CK6 and CK8 bound between residues 80 and 104 of HveC, suggesting that part of the gD binding site colocalizes in the same region...
  77. ncbi Differences between HA receptor-binding sites of avian influenza viruses isolated from Laridae and Anatidae
    S S Yamnikova
    D I Ivanovsky Institute of Virology, RAMS, 123098 Gamaleya, 16, Moscow, Russia
    Avian Dis 47:1164-8. 2003
    ..A comparative analysis of six sequenced HA H13 viruses and other subtype viruses showed presence of substantial differences in the composition of amino acids of this region in H13 viruses...
  78. pmc Nectin/PRR: an immunoglobulin-like cell adhesion molecule recruited to cadherin-based adherens junctions through interaction with Afadin, a PDZ domain-containing protein
    K Takahashi
    Takai Biotimer Project, ERATO, Japan Science and Technology Corp, c o JCR Pharmaceuticals Co, Ltd, Kobe 651 2241, Japan
    J Cell Biol 145:539-49. 1999
    ..We rename PRR as nectin (taken from the Latin word "necto" meaning "to connect")...
  79. ncbi alpha(6) Integrin is the main receptor of human papillomavirus type 16 VLP
    C S Yoon
    Genome Research Center, Korea Research Institute of Bioscience and Biotechnology, Taejeon, 305-600, Korea
    Biochem Biophys Res Commun 283:668-73. 2001
    ..The degree of binding of HPV-VLP matched the alpha(6) integrin expression level in cell lines but was not correlated with beta(1) and beta(4) levels, which suggests that alpha(6) integrin is the main receptor of HPV type 16...
  80. ncbi Influenza A virus receptors in the respiratory and intestinal tracts of pigeons
    Yuehuan Liu
    Institute of Animal and Husbandry Medicine, Beijing Academy of Agriculture and Forestry Sciences, Beijing, PR China
    Avian Pathol 38:263-6. 2009
    ..lineage highly pathogenic avian influenza virus (HPAIV) subtype H5N1, we examined the presence of influenza virus receptors, sialic acids linked to galactose by an alpha-2,3 linkage (SAalpha2,3Gal) or by an alpha-2,6 linkage (..
  81. ncbi Characterization of a panel of cell lines derived from urothelial neoplasms: genetic alterations, growth in vivo and the relationship of adenoviral mediated gene transfer to coxsackie adenovirus receptor expression
    Anita Sabichi
    Department of Clinical Cancer Prevention, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Urol 175:1133-7. 2006
    ..Cell lines have become an essential component for the investigation of cancer. We have developed a panel of cell lines derived from human urothelial cancers and we describe some of their important characteristics...
  82. ncbi A cell surface protein with herpesvirus entry activity (HveB) confers susceptibility to infection by mutants of herpes simplex virus type 1, herpes simplex virus type 2, and pseudorabies virus
    M S Warner
    Department of Microbiology Immunology, Northwestern University Medical School, Chicago, Illinois 60611, USA
    Virology 246:179-89. 1998
    ..Differences in ability of HSV-1 and HSV-2 strains to use HveB for entry should influence the types of cells that can be infected and thereby account in part for serotype and strain differences in tissue tropism and pathogenicity...
  83. pmc Herpes simplex virus glycoprotein D can bind to poliovirus receptor-related protein 1 or herpesvirus entry mediator, two structurally unrelated mediators of virus entry
    C Krummenacher
    Department of Microbiology, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Virol 72:7064-74. 1998
    ..Thus, we propose that HSV entry can be mediated by two structurally unrelated gD receptors through related but not identical binding with gD...
  84. ncbi The HTLV receptor is an early T-cell activation marker whose expression requires de novo protein synthesis
    Nicolas Manel
    Institut de Genetique Moleculaire de Montpellier, CNRS UMR 5535 IFR 24, F 34293 Montpellier cedex 5, France
    Blood 101:1913-8. 2003
    ..Up-regulation of the HTLV receptor, via signals transmitted through the IL-7 cytokine receptor as well as the TCR, is likely to contribute to the mother-to-infant transmission and spreading of HTLV-1...
  85. ncbi EphrinB2 is the entry receptor for Nipah virus, an emergent deadly paramyxovirus
    Oscar A Negrete
    Department of Microbiology, Immunology and Molecular Genetics, UCLA, Los Angeles, California 90095, USA
    Nature 436:401-5. 2005
    ..Cumulatively, our data show that ephrinB2 is a functional receptor for NiV...
  86. ncbi Expression of the DNAM-1 ligands, Nectin-2 (CD112) and poliovirus receptor (CD155), on dendritic cells: relevance for natural killer-dendritic cell interaction
    Daniela Pende
    Istituto Nazionale per la Ricerca sul Cancro, L go R Benzi 10, 16132 Genova, Italy
    Blood 107:2030-6. 2006
    ....
  87. pmc A putative thiamine transport protein is a receptor for feline leukemia virus subgroup A
    Ramon Mendoza
    Program in Molecular and Cellular Biology, University of Washington, Seattle, USA
    J Virol 80:3378-85. 2006
    ..Identification of this receptor will allow more detailed studies of the early events in FeLV transmission and may provide insights into FeLV pathogenesis...
  88. ncbi Role of sialic acid-containing molecules in paramyxovirus entry into the host cell: a minireview
    Enrique Villar
    Departamento de Bioquimica y Biologia Molecular, Edificio Departamental, Universidad de Salamanca, Plaza Doctores de la Reina s n, Lab 108, Salamanca 37007, Spain
    Glycoconj J 23:5-17. 2006
    ..In spite of all these data, the exact nature of paramyxovirus receptors, apart from their sialylated nature, and the mechanism(s) of viral attachment to the cell surface are poorly understood...
  89. pmc Serotype-specific entry of dengue virus into liver cells: identification of the 37-kilodalton/67-kilodalton high-affinity laminin receptor as a dengue virus serotype 1 receptor
    Chutima Thepparit
    Molecular Pathology Laboratory, Institute of Molecular Biology and Genetics, Mahidol University, 25 25 Phuttamontol Sai 4, Salaya, Nakorn Pathom, Thailand 73170
    J Virol 78:12647-56. 2004
    ..No inhibition of virus entry was seen with dengue virus serotypes 2, 3, or 4, demonstrating that the 37/67-kDa high-affinity laminin receptor is a serotype-specific receptor for dengue virus entry into liver cells...
  90. pmc Human membrane cofactor protein (CD46) acts as a cellular receptor for measles virus
    D Naniche
    CNRS ENS Lyon UMR 49, France
    J Virol 67:6025-32. 1993
    ..These results show that the human CD46 molecule serves as an MV receptor allowing virus-cell binding, fusion, and viral replication and open new perspectives in the study of MV pathogenesis...
  91. ncbi Host species barriers to influenza virus infections
    Thijs Kuiken
    Department of Virology, Erasmus Medical Center, 3015 GE Rotterdam, Netherlands
    Science 312:394-7. 2006
    ....
  92. ncbi Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus
    Wenhui Li
    Partners AIDS Research Center, Brigham and Women s Hospital, Department of Medicine Microbiology and Molecular Genetics, Boston, Massachusetts 02115, USA
    Nature 426:450-4. 2003
    ..Finally, anti-ACE2 but not anti-ACE1 antibody blocked viral replication on Vero E6 cells. Together our data indicate that ACE2 is a functional receptor for SARS-CoV...
  93. pmc Role of virus receptor Hyal2 in oncogenic transformation of rodent fibroblasts by sheep betaretrovirus env proteins
    Shan Lu Liu
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    J Virol 77:2850-8. 2003
    ....
  94. ncbi Growth and production of the dengue virus in C6/36 cells and identification of a laminin-binding protein as a candidate serotype 3 and 4 receptor protein
    Prirayapak Sakoonwatanyoo
    Molecular Pathology Laboratory, Institute of Molecular Biology and Genetics, Mahidol University, Bangkok, Thailand
    Intervirology 49:161-72. 2006
    ....
  95. ncbi Entry of alphaherpesviruses mediated by poliovirus receptor-related protein 1 and poliovirus receptor
    R J Geraghty
    Department of Microbiology Immunology, Northwestern University Medical School, Chicago, IL 60611, USA
    Science 280:1618-20. 1998
    ..HveC was expressed in human cells of epithelial and neuronal origin; it is the prime candidate for the coreceptor that allows both HSV-1 and HSV-2 to infect epithelial cells on mucosal surfaces and spread to cells of the nervous system...
  96. ncbi Hepatitis C virus cell-cell transmission in hepatoma cells in the presence of neutralizing antibodies
    Jennifer M Timpe
    Institute for Biomedical Research, University of Birmingham, Birmingham, United Kingdom
    Hepatology 47:17-24. 2008
    ..Further experiments with 293T and 293T-CLDN1 targets suggested that cell-cell transmission is dependent on CLDN1 expression...
  97. ncbi Heparan sulfate: anchor for viral intruders?
    D Spillmann
    Department of Medical Biochemistry and Microbiology, The Biomedical Center, Uppsala University, Box 582, 75 123 Uppsala, Sweden
    Biochimie 83:811-7. 2001
    ....
  98. pmc Identification of gangliosides GD1b and GT1b as receptors for BK virus
    Jonathan A Low
    Department of Microbiology and Immunology, University of Michigan Medical School, 1500 E Medical Center Dr, 6304 Cancer Center, Ann Arbor, MI 48109 0942, USA
    J Virol 80:1361-6. 2006
    ..These data demonstrate that BKV uses the gangliosides GT1b and GD1b as receptors and passes through the ER on the way to the nucleus...
  99. pmc Heat shock cognate protein 70 is involved in rotavirus cell entry
    Carlos A Guerrero
    , , , Cuernavaca, Morelos 62250, Mexico, USA
    J Virol 76:4096-102. 2002
    ..We propose that the functional rotavirus receptor is a complex of several cell surface molecules that include, among others, hsc70...
  100. ncbi Coxsackievirus-adenovirus receptor (CAR) is essential for early embryonic cardiac development
    Armin A Dorner
    Max Delbruck Center for Molecular Medicine, Berlin Buch, Robert Rössie Strasse10, 13125 Berlin, Germany
    J Cell Sci 118:3509-21. 2005
    ..We conclude that CAR is required for embryonal heart development, most likely due to its function during the organization of myofibrils in cardiomyocytes...
  101. pmc C-type lectins DC-SIGN and L-SIGN mediate cellular entry by Ebola virus in cis and in trans
    Carmen P Alvarez
    Laboratory of Molecular Microbiology, Dept of Microbiology, Hospital 12 de Octubre, 28041 Madrid, Spain
    J Virol 76:6841-4. 2002
    ..Our data underscore a role for DC-SIGN and L-SIGN in the infective process and pathogenicity of Ebola virus infection...

Research Grants62

  1. Mechanisms of cytokine-mediated viral clearance from neurons
    LAUREN ALENE O apos DONNELL; Fiscal Year: 2010
    ..transgenic mouse model of CNS-restricted MV infection via targeted neuronal expression of one of the measles virus receptors (CD46) to study interactions between MV-infected neurons and the immune response...
  2. Entry and Pathogenesis of Coronaviruses
    THOMAS MILLER GALLAGHER; Fiscal Year: 2011
    ..relevant to coronavirus activation are those that are naturally (endogenously) linked to the primary virus receptors. We have evidence for a linkage between a transmembrane protease and a human coronavirus receptor and our ..
  3. High-Expression, Rapid Production of Influenza Vaccines in Cell-Based Systems
    Vitaliy Gavrilyuk; Fiscal Year: 2013
    ..The first technology, developed by FluGen, increases the number of surface bound influenza virus receptors for expanding the amount of virus that can infect the cell...
  4. LDV-INDUCED GENETICALLY RESTRICTED CNS DISEASE
    MARGO BRINTON; Fiscal Year: 1991
    ..antibodies, which in turn could be used to localize and define virus- susceptible cell populations and virus receptors. Our preliminary data indicate that LDV-C infection of C57BR/cd mice may trigger an allergic ..
  5. CELL SURFACE PROTEINS INVOLVED IN ECHOVIRUS ATTACHMENT
    Robert Finberg; Fiscal Year: 1999
    ..As a group the 32 serotypes of echovirus are the major cause of meningitis in the United States. Virus receptors are cell surface proteins which allow for virus binding to the host cell, the initial step in viral ..
  6. Measles virus receptors in the cotton rat model
    Stefan Niewiesk; Fiscal Year: 2006
    ..on this data, we hypothesize that in cotton rats analogs to human CD 150 and human CD46 function as measles virus receptors. We propose to characterize these receptor molecules by using techniques which have successfully been ..
  7. THE BACTERIAL SURFACE AND ITS MULTIFUNCTIONAL DOMAINS
    Manfred Bayer; Fiscal Year: 1990
    ..export of polysaccharides and proteins; and 3) the functional clusters which incorporate the great variety of virus receptors and also represent the sites at which membrane components are inserted into the growing cell surface...
  8. Broadly Inhibitory MAbs Targeting Hepatitis C Virus Receptors
    Sofija Andjelic; Fiscal Year: 2007
    ..Our goal in this project is to translate recent discoveries in HCV entry into novel therapeutic drug candidates and to ultimately identify the primary cellular receptor for HCV. [unreadable] [unreadable] [unreadable]..
  9. TOGAVIRUS REPLICATION STRATEGIES AND EVOLUTION
    James Strauss; Fiscal Year: 2004
    ..relationships among the alphaviruses, the three dimensional structure of the viruses , the identification of virus receptors and the pathogenicity of flavi viruses...
  10. Molecular Mechanisms of Systemic Adenovirus Toxicity
    Dmitry Shayakhmetov; Fiscal Year: 2004
    ..on the data obtained, in our fourth specific aim we will construct an Ad vector ablated for binding to known virus receptors and capable of infecting cells via an alternative receptor, LDLR...
  11. GENETIC RESISTANCE TO LETHAL FLAVIVIRAL ENCEPHALITIS
    Abigail Smith; Fiscal Year: 1980
    ..Finally, the hypothesis that qualitative and/or quantitative differences may exist between the 2 strains in cell membrane virus receptors on target cells in the brain and lymphoid tissues will be examined.
  12. ROLE OF LIPID RAFTS IN HIV-1 ENTRY
    Waldemar Popik; Fiscal Year: 2001
    ..Since HIV-1 entry requires cooperation between multiple virus receptors, distribution of these receptors in different rafts may have important implications for the rate and ..
  13. ROLE OF LIPID RAFTS IN HIV-1 ENTRY
    Waldemar Popik; Fiscal Year: 2005
    ..Since HIV-1 entry requires cooperation between multiple virus receptors, distribution of these receptors in different rafts may have important implications for the rate and ..
  14. Junction Adhesion Molecule CAR and the Immune System
    Steven Carson; Fiscal Year: 2007
    ..This work will advance knowledge of cells that form tight _junctions and their interactions with cells and molecules that must cross those barriers. ..
  15. Molecular Therapy Core Centers
    Arthur Miller; Fiscal Year: 2008
    ..abstract_text> ..
  16. MYOCARDITIS--RECEPTORS FOR A CARDIOTROPIC VIRUS
    Jeffrey Bergelson; Fiscal Year: 2001
    ..Because a murine CAR homologue functions as the coxsackievirus receptor in mice, we will also use murine models, including transgenic and knock-out animals, to define the role of the coxsackie receptor in viral pathogenesis. ..
  17. Naturalization-Resistant Adenovirus Vaccine Vector
    Jeffrey Bergelson; Fiscal Year: 2005
    ..Such a chimeric vector could solve one of the major obstacles to the use of adenovirus vectors for HIV immunization. ..
  18. Interactions of herpes simplex virus with nectin-1 at cell junctions
    Claude Krummenacher; Fiscal Year: 2008
    ..By identifying new requirements for virus entry in the host, this study will provide targets for novel therapeutic approaches to interfere with this process. [unreadable] [unreadable] [unreadable]..
  19. Cell Biology of Enterovirus Infection in Polarized Epithelial Cells
    Jeffrey Bergelson; Fiscal Year: 2007
    ..Understanding the special mechanisms by which they infect polarized cells will reveal new potential drug targets. ..
  20. Herpes simplex virus receptors and signal transduction
    PATRICIA SPEAR; Fiscal Year: 2003
    ..The studies described in this proposal are distinct from those supported by the parent grant but address questions that arise from findings made in the parent project. ..
  21. Multivalent display of anthrax toxin inhibitors
    Marianne Manchester; Fiscal Year: 2007
    ..abstract_text> ..
  22. T CELL RESPONSE TO MYELIN PROTEOLIPID PROTEIN
    Vijay Kuchroo; Fiscal Year: 2008
    ..abstract_text> ..
  23. Receptor usage and pathogenicity of feline lentiviruses
    BRIAN WILLETT; Fiscal Year: 2007
    ..abstract_text> ..
  24. ENTRY OF HERPES SIMPLEX VIRUS INTO CELLS
    PATRICIA SPEAR; Fiscal Year: 2008
    ..abstract_text> ..
  25. INTL CONG OF VIROLOGY, SAN FRANCISCO, ASV TRAVEL REQUEST
    PATRICIA SPEAR; Fiscal Year: 2005
    ....
  26. ANTITUMOR AND COSTIMULATORY ACTIVITY OF B7 ON T CELLS
    Vijay Kuchroo; Fiscal Year: 2002
    ..2 and B7.1 plus B7.2 transfected EL-4 cells and test the mechanism by which they inhibit anti-tumor immunity. ..
  27. Cellular receptors for pathogenic New World arenaviruses
    Stefan Kunz; Fiscal Year: 2007
    ..In a complementary approach, biochemical techniques, combined with mass spectrometry, will therefore be used for the identification of candidate receptors for this important human pathogen. [unreadable] [unreadable] [unreadable]..
  28. Expression of the coxsackievirus and adenovirus receptor
    Christopher Cohen; Fiscal Year: 2002
    ..The experiments outlined below will define CAR's function in virus infection of epithelial cells, and its contribution to the formation and structure of the epithelial tight junction. ..
  29. Genetic Basis for susceptibility to Experimental Autoimmune Encephalomyelitis
    Vijay Kuchroo; Fiscal Year: 2008
    ..abstract_text> ..
  30. Norwalk-like Viruses and Their Receptors
    Xi Jiang; Fiscal Year: 2009
    ..Specific aim 3. To determine the crystal structure of NLV capsid and sub-capsid units in the presence and absence of human histo-blood group antigens. ..
  31. Antigenic structure of adeno-associated virus capsids and antibody escape mutants
    Colin Parrish; Fiscal Year: 2008
    ..In this study we seek to define the antigenic structures if the viruses so that the adverse effects of antibodies on gene therapy trials can be better understood, and perhaps avoided in the future. [unreadable] [unreadable] [unreadable]..
  32. A NOVEL STRATEGY FOR OSTEOPOROSIS GENE THERAPY
    Joanne Douglas; Fiscal Year: 2003
    ..The realization of these Specific Aims would establish the feasibility of this approach as a rational strategy for gene therapy in patients with end-stage, low-turnover osteoporosis. ..
  33. Mechanisms by which Influenza A Protects Against Asthma
    DALE UMETSU; Fiscal Year: 2008
    ..We will also learn more about regulatory mechanisms that affect airway inflammation, and how viral infections and the environment affect the development of asthma. ..
  34. T reg Cells in Myocarditis
    Sally A Huber; Fiscal Year: 2010
    ..Determine whether the T reg cells are antigen specific (virus), cardiovascular specific (autoimmunity), or non-antigen specific. ..
  35. TWO NOVEL CPLA2 BINDING PROTEINS AND CELL DEATH
    JOSEPH VINCENT BONVENTRE; Fiscal Year: 2010
    ..Given the large number of patients that are initiated on dialysis each year, this addresses a critical public health problem. ..
  36. The Cytoskeleton in HAART-Induced Cardiomyopathy
    David Nelson; Fiscal Year: 2006
    ..Specific Aim 2: Characterization of the cytoskeleton in HAART-treated transgenic mice. Specific Aim 3: Role of extrinsic stimuli in the development of HAART-induced cardiomyopathy. ..
  37. CD4+ T CELLS PROMOTE EARLY ATHEROSCLEROSIS
    Sally Huber; Fiscal Year: 2002
    ..Specific Aim 3 will investigate the role of CD4+ T cells in atherogenesis and evaluate whether these cells promote Th1 cell dominance. ..
  38. Heterogeneity among human CD4 T lymphocytes
    Dale T Umetsu; Fiscal Year: 2010
    ..We are proposing new paradigms for the pathogenesis of asthma, and these new paradigms should lead to an improved understanding of asthma and to important novel therapies for asthma and allergy. ..
  39. TNFR Members in T Cell Immunity to Vaccinia
    Michael Croft; Fiscal Year: 2010
    ....
  40. Characterization of Human Caliciviruses
    Xi Jiang; Fiscal Year: 2010
    ..abstract_text> ..
  41. MECHANISMS OF PARVOVIRUS INFECTION AND HOST RANGE
    Colin R Parrish; Fiscal Year: 2011
    ..We would seek to complement endosomal escape mutants in trans by adding adenovirus capsids, competent wild type parvovirus, or transferrin-PEI conjugates to the cells along with the parvoviruses. ..
  42. The Role of 4-1BB in T Cell and APC Interactions
    Michael Croft; Fiscal Year: 2010
    ..abstract_text> ..
  43. Third International Calicivirus Conference
    Xi Jiang; Fiscal Year: 2007
    ..We will publish a proceeding of the meeting as a supplement of the Journal of[unreadable] Infectious Diseases after the meeting. ..
  44. PARVOVIRUS STRUCTURE, CAPSID ASSEMBLY, AND RECEPTORS
    Colin Parrish; Fiscal Year: 2007
    ..abstract_text> ..
  45. Oral Tolerance Induced by Encapsulated Allergen
    DALE UMETSU; Fiscal Year: 2004
    ..These studies therefore, are likely to lead to better methods and therapies that will induce protective immunity and allergen-specific tolerance, which will potentially cure patients with asthma and allergic diseases. ..
  46. Role of Th Cell Subsets in Allergic Lung Inflammation
    DALE UMETSU; Fiscal Year: 2007
    ..These studies will ascertain the precise role of NK T cells in the development of asthma, and greatly enhance our understanding of pathogenic and protective mechanisms in asthma. ..
  47. Sex in Viral Myocarditis
    Sally Huber; Fiscal Year: 2004
    ..These studies may provide new insights as to how viruses affect developing host defense responses and how hormones can modulate this initial response. ..
  48. Roles of KIM-1 in Renal Injury and Repair
    WON HAN; Fiscal Year: 2007
    ..abstract_text> ..
  49. CDI and Gamma Delta+ in Viral Myocarditis
    Sally Huber; Fiscal Year: 2005
    ..abstract_text> ..
  50. Sex in Myocarditis
    Sally Huber; Fiscal Year: 2008
    ..By understanding the factors controlling virus infection and induction of innate immunity, better mechanism for controlling viral disease should be possible. ..
  51. INTRACEULLULAR ANTI-TAT ANTIBODIES FOR AIDS GENE THERAPY
    Wayne Marasco; Fiscal Year: 2002
    ..Our immediate goal is to use this knowledge to aid in small molecule inhibitor design, our long term goal is to use these intrabodies in a clinical gene therapy trial. ..
  52. Enterovirus Pathogenesis
    VINCENT RACANIELLO; Fiscal Year: 2007
    ..The biological role of poliovirus-induced cleavage of RIG-I and MDA-5 will be determined. Because poliovirus is a model pathogen, the results will contribute to the control of other medically relevant viruses. ..
  53. The Adenovirus Receptor CAR in Epithelial Malignancies
    WOLFGANG KORN; Fiscal Year: 2007
    ..abstract_text> ..
  54. Pathogenesis Studies in Scrapie (TSE Diseases)
    Michael Oldstone; Fiscal Year: 2003
    ..This model should be useful to study pathophysiology of CWD as well as probing CWD strain differences. ..
  55. Ligand-gated Transport through FepA
    PHILLIP KLEBBA; Fiscal Year: 2009
    ..We will use fluorescence methods to study these questions. ..
  56. HUMAN ANTITAT INTRABODY GENE THERAPY AGAINST SHIV
    Wayne Marasco; Fiscal Year: 2001
    ..In addition, the results from these studies will substantially advance our understanding of how to apply and improve this promising technology for the treatment of HIV-1 infection and AIDS. ..
  57. Molecular Mechanism of HIV-1 Vif Function
    BRYAN CULLEN; Fiscal Year: 2007
    ..Together, this wide-ranging series of experiments should lead to considerable insight into how HIV-1 Vif functions and potentially suggest approaches to inhibit Vif function. ..
  58. A Novel Therapeutics for Pandemic & Epidemic Flu
    Fang Fang; Fiscal Year: 2005
    ..In the proposed phase I study, we will generate this proteinase inhibitor and its fusion proteins, compare their functional activities in vitro and choose the best construct for phase II study. ..
  59. ROLE OF ICOS IN T CELL RESPONSES AND ANTI-TUMOR IMMUNITY
    Gordon Freeman; Fiscal Year: 2004
    ..To examine the expression the expression of ICOS counter-receptor on APC and characterize its molecular structure. SPECIFIC AIM 3. To examine how blocking ICOS signals affect the immune response to murine tumors. ..