vascular endothelial growth factor receptor 2

Summary

Summary: A 200-230-kDa tyrosine kinase receptor for vascular endothelial growth factors found primarily in endothelial and hematopoietic cells and their precursors. VEGFR-2 is important for vascular and hematopoietic development, and mediates almost all endothelial cell responses to VEGF.

Top Publications

  1. pmc VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia
    Holger Gerhardt
    Deparrment of Medical Biochemistry, University of Goteborg, Medicinaregatan 9A, Box 440, SE 405 30 Goteborg, Sweden
    J Cell Biol 161:1163-77. 2003
  2. pmc Autocrine VEGF signaling is required for vascular homeostasis
    Sunyoung Lee
    Department of Molecular, Cellular and Developmental Biology, Jonsson Comprehensive Cancer Center and Molecular Biology Institute, UCLA, Los Angeles, CA 90095, USA
    Cell 130:691-703. 2007
  3. ncbi Ligand-independent activation of vascular endothelial growth factor receptor 2 by fluid shear stress regulates activation of endothelial nitric oxide synthase
    Zheng Gen Jin
    Center for Cardiovascular Research and Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Circ Res 93:354-63. 2003
  4. pmc Acquired expression of periostin by human breast cancers promotes tumor angiogenesis through up-regulation of vascular endothelial growth factor receptor 2 expression
    Rong Shao
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Mol Cell Biol 24:3992-4003. 2004
  5. pmc VEGF receptor-2 Y951 signaling and a role for the adapter molecule TSAd in tumor angiogenesis
    Taro Matsumoto
    Rudbeck Laboratory, Department of Genetics and Pathology, Uppsala University, Uppsala, Sweden
    EMBO J 24:2342-53. 2005
  6. ncbi VEGF expression and receptor activation in the choroid during development and in the adult
    Magali Saint-Geniez
    Schepens Eye Research Institute, The Department of Ophthalmology, Children s Hospital, Harvard Medical School, Boston, MA 02114, USA
    Invest Ophthalmol Vis Sci 47:3135-42. 2006
  7. ncbi Vascular endothelial growth factor induces chemotaxis and proliferation of microglial cells
    Frauke Forstreuter
    Department of Anatomy, University of Kiel, Olshausenstrasse 40, D 24098 Kiel, Germany
    J Neuroimmunol 132:93-8. 2002
  8. pmc Vascular endothelial cadherin controls VEGFR-2 internalization and signaling from intracellular compartments
    Maria Grazia Lampugnani
    IFOM, Fondazione Italiana per la Ricerca sul Cancro Institute of Molecular Oncology, University of Milan, 20139 Milan, Italy
    J Cell Biol 174:593-604. 2006
  9. ncbi A phase I study of foretinib, a multi-targeted inhibitor of c-Met and vascular endothelial growth factor receptor 2
    Joseph Paul Eder
    Early Drug Development Center, Department of Medical Oncology, Dana Farber Cancer Institute and Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Clin Cancer Res 16:3507-16. 2010
  10. ncbi Signal transduction by VEGF receptors in regulation of angiogenesis and lymphangiogenesis
    Masabumi Shibuya
    University of Tokyo, Institute of Medical Science, 4 6 1 Shirokane dai, Tokyo 108 8639, Japan
    Exp Cell Res 312:549-60. 2006

Detail Information

Publications318 found, 100 shown here

  1. pmc VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia
    Holger Gerhardt
    Deparrment of Medical Biochemistry, University of Goteborg, Medicinaregatan 9A, Box 440, SE 405 30 Goteborg, Sweden
    J Cell Biol 161:1163-77. 2003
    ..Thus, vessel patterning during retinal angiogenesis depends on the balance between two different qualities of the extracellular VEGF-A distribution, which regulate distinct cellular responses in defined populations of endothelial cells...
  2. pmc Autocrine VEGF signaling is required for vascular homeostasis
    Sunyoung Lee
    Department of Molecular, Cellular and Developmental Biology, Jonsson Comprehensive Cancer Center and Molecular Biology Institute, UCLA, Los Angeles, CA 90095, USA
    Cell 130:691-703. 2007
    ..These results reveal a cell-autonomous VEGF signaling pathway that holds significance for vascular homeostasis but is dispensable for the angiogenic cascade...
  3. ncbi Ligand-independent activation of vascular endothelial growth factor receptor 2 by fluid shear stress regulates activation of endothelial nitric oxide synthase
    Zheng Gen Jin
    Center for Cardiovascular Research and Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Circ Res 93:354-63. 2003
    ..In this study, we found that laminar flow (shear stress=12 dyne/cm2) rapidly activates vascular endothelial growth factor receptor 2 (VEGFR2) in a ligand-independent manner and leads to eNOS activation in cultured endothelial ..
  4. pmc Acquired expression of periostin by human breast cancers promotes tumor angiogenesis through up-regulation of vascular endothelial growth factor receptor 2 expression
    Rong Shao
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Mol Cell Biol 24:3992-4003. 2004
    ..These findings demonstrate the presence of a novel mechanism by which tumor angiogenesis is acquired with the expression of a mesenchyme-specific gene as a crucial step in late stages of tumorigenesis...
  5. pmc VEGF receptor-2 Y951 signaling and a role for the adapter molecule TSAd in tumor angiogenesis
    Taro Matsumoto
    Rudbeck Laboratory, Department of Genetics and Pathology, Uppsala University, Uppsala, Sweden
    EMBO J 24:2342-53. 2005
    ..Tumor vascularization and growth was reduced in TSAd-deficient mice, indicating a critical role of Y951-TSAd signaling in pathological angiogenesis...
  6. ncbi VEGF expression and receptor activation in the choroid during development and in the adult
    Magali Saint-Geniez
    Schepens Eye Research Institute, The Department of Ophthalmology, Children s Hospital, Harvard Medical School, Boston, MA 02114, USA
    Invest Ophthalmol Vis Sci 47:3135-42. 2006
    ....
  7. ncbi Vascular endothelial growth factor induces chemotaxis and proliferation of microglial cells
    Frauke Forstreuter
    Department of Anatomy, University of Kiel, Olshausenstrasse 40, D 24098 Kiel, Germany
    J Neuroimmunol 132:93-8. 2002
    ..These results show that microglial cells are targets for VEGF which induces migration and proliferation of these immunocompetent cells in the brain...
  8. pmc Vascular endothelial cadherin controls VEGFR-2 internalization and signaling from intracellular compartments
    Maria Grazia Lampugnani
    IFOM, Fondazione Italiana per la Ricerca sul Cancro Institute of Molecular Oncology, University of Milan, 20139 Milan, Italy
    J Cell Biol 174:593-604. 2006
    ..Thus, VEC limits cell proliferation by retaining VEGFR-2 at the membrane and preventing its internalization into signaling compartments...
  9. ncbi A phase I study of foretinib, a multi-targeted inhibitor of c-Met and vascular endothelial growth factor receptor 2
    Joseph Paul Eder
    Early Drug Development Center, Department of Medical Oncology, Dana Farber Cancer Institute and Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Clin Cancer Res 16:3507-16. 2010
    ..Secondary objectives included evaluation of plasma pharmacokinetics, long-term safety after repeated administration, preliminary antitumor activity, and pharmacodynamic activity...
  10. ncbi Signal transduction by VEGF receptors in regulation of angiogenesis and lymphangiogenesis
    Masabumi Shibuya
    University of Tokyo, Institute of Medical Science, 4 6 1 Shirokane dai, Tokyo 108 8639, Japan
    Exp Cell Res 312:549-60. 2006
    ..Mapping the signaling system of these important receptors may provide the knowledge necessary to suppress specific signaling pathways in major human diseases...
  11. ncbi Direct stimulation of adult neural stem cells in vitro and neurogenesis in vivo by vascular endothelial growth factor
    Anne Schänzer
    Institute of Neurology Edinger Institute, Johann Wolfgang Goethe University, Frankfurt Main, Germany
    Brain Pathol 14:237-48. 2004
    ..We propose that VEGF acts as a trophic factor for neural stem cells in vitro and for sustained neurogenesis in the adult nervous system. These findings may have implications for the pathogenesis and therapy of neurodegenerative diseases...
  12. ncbi Phase I clinical trial using peptide vaccine for human vascular endothelial growth factor receptor 2 in combination with gemcitabine for patients with advanced pancreatic cancer
    Motoki Miyazawa
    Second Department of Surgery, Wakayama Medical University, Wakayama, Japan
    Cancer Sci 101:433-9. 2010
    b>Vascular endothelial growth factor receptor 2 (VEGFR2) is an essential factor in tumor angiogenesis and in the growth of pancreatic cancer...
  13. ncbi Treatment of transplanted CT26 tumour with dendritic cell vaccine in combination with blockade of vascular endothelial growth factor receptor 2 and CTLA-4
    A E Pedersen
    Laboratory of Cellular Immunology, Department of Medical Anatomy A, The Panum Institute, University of Copenhagen, Denmark
    Cancer Lett 235:229-38. 2006
    ..However, effective treatment of mice with already established tumours was only obtained after combination of vaccination, DC101 and 9H10 treatment in which setting 80% of the mice rejected their tumours...
  14. ncbi Role of PlGF in the intra- and intermolecular cross talk between the VEGF receptors Flt1 and Flk1
    Monica Autiero
    The Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, KULeuven, Leuven, B 3000, Belgium
    Nat Med 9:936-43. 2003
    ....
  15. ncbi Inhibition of vascular endothelial growth factor receptor 2 activity in experimental brain contusions aggravates injury outcome and leads to early increased neuronal and glial degeneration
    Mattias K Sköld
    Department of Neuroscience, Karolinska Institutet, S 17177 Stockholm, Sweden
    Eur J Neurosci 23:21-34. 2006
    ..The possible importance of VEGF on the vascular, neuronal and glial compartments of the neurovascular unit after TBI is discussed...
  16. pmc Endothelial-specific expression of caveolin-1 impairs microvascular permeability and angiogenesis
    Philip M Bauer
    Department of Pharmacology and Vascular Cell Signaling and Therapeutics Program, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, CT 06536, USA
    Proc Natl Acad Sci U S A 102:204-9. 2005
    ..These data strongly support the idea that, in vivo, Cav-1 may modulate signaling pathways independent of its essential role in caveolae biogenesis...
  17. ncbi A mechanosensory complex that mediates the endothelial cell response to fluid shear stress
    Eleni Tzima
    Department of Cell Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Nature 437:426-31. 2005
    ..Therefore, this mechanosensing pathway is required for the earliest-known events in atherogenesis...
  18. ncbi Complex formation between tissue transglutaminase II (tTG) and vascular endothelial growth factor receptor 2 (VEGFR-2): proposed mechanism for modulation of endothelial cell response to VEGF
    Rima Dardik
    Institute of Thrombosis and Hemostasis, Sheba Medical Center, Tel Hashomer 52621, Israel
    Exp Cell Res 312:2973-82. 2006
    ....
  19. ncbi Microvessel density and the association with single nucleotide polymorphisms of the vascular endothelial growth factor receptor 2 in patients with colorectal cancer
    Torben Frøstrup Hansen
    Department of Oncology, Danish Colorectal Cancer Group South, Vejle Hospital, Kabbeltoft 25, 7100, Vejle, Denmark
    Virchows Arch 456:251-60. 2010
    ..Moreover, an association between the SNPs and survival was demonstrated. The clinical implications of these findings need further investigations...
  20. ncbi Interactions of VEGF isoforms with VEGFR-1, VEGFR-2, and neuropilin in vivo: a computational model of human skeletal muscle
    Feilim Mac Gabhann
    Dept of Biomedical Engineering, Johns Hopkins Univ School of Medicine, 720 Rutland Ave, 613 Traylor Bldg, Baltimore, MD 21205, USA
    Am J Physiol Heart Circ Physiol 292:H459-74. 2007
    ..This model is the first to study VEGF tissue distribution and receptor activation in human muscle, and it provides a platform for the design and evaluation of therapeutic approaches...
  21. pmc An anti-vascular endothelial growth factor receptor 2/fetal liver kinase-1 Listeria monocytogenes anti-angiogenesis cancer vaccine for the treatment of primary and metastatic Her-2/neu+ breast tumors in a mouse model
    Matthew M Seavey
    Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Immunol 182:5537-46. 2009
    ..a central cell type involved in angiogenesis, endothelial cells, we immunized against host vascular endothelial growth factor receptor 2 to fight the growth of Her-2/neu(+) breast tumors...
  22. ncbi Evidence for novel fate of Flk1+ progenitor: contribution to muscle lineage
    Toshiyuki Motoike
    The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 8573, USA
    Genesis 35:153-9. 2003
    ..Studies with these Cre lines provide direct evidence that Flk1(+) cells are progenitors for muscles, in addition to hematopoietic and vascular endothelial cells...
  23. pmc Protein kinase D-dependent phosphorylation and nuclear export of histone deacetylase 5 mediates vascular endothelial growth factor-induced gene expression and angiogenesis
    Chang Hoon Ha
    Aab Cardiovascular Research Institute and Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14586, USA
    J Biol Chem 283:14590-9. 2008
    ..These findings suggest that the PKD-HDAC5 pathway plays an important role in VEGF regulation of gene transcription and angiogenesis...
  24. ncbi Endothelial and hematopoietic cell fate of human embryonic stem cells originates from primitive endothelium with hemangioblastic properties
    Lisheng Wang
    Robarts Research Institute, Krembil Centre for Stem Cell Biology and Regenerative Medicine, 100 Perth Drive, London, Ontario N6A 5K8, Canada
    Immunity 21:31-41. 2004
    ....
  25. ncbi Mechanisms underlying TGF-beta1-induced expression of VEGF and Flk-1 in mouse macrophages and their implications for angiogenesis
    Seong Hyun Jeon
    Department of Molecular Bioscience, School of Bioscience and Biotechnology, Kangwon National University, Chunchon, Korea
    J Leukoc Biol 81:557-66. 2007
    ..The results from the present study indicate that TGF-beta1 can activate mouse macrophages to express angiogenic mediators such as VEGF, MMP-9, and Flk-1...
  26. ncbi Vascular endothelial growth factor receptor-2 activation induces vascular permeability in hyperstimulated rats, and this effect is prevented by receptor blockade
    Raul Gomez
    Fundación IVI para el Estudio de la Reproducción, Valencia, Spain
    Endocrinology 143:4339-48. 2002
    ..These results show that the ovary is the main source of VEGF(120) and VEGF(164), which act through the VEGF receptor-2 to increase VP, and provide new insights into the prevention of OHSS...
  27. ncbi VEGF, VEGFRs expressions and activated STATs in ovarian epithelial carcinoma
    Huaizeng Chen
    Central Laboratory, Women s Hospital, School of Medicine, Zhejiang University, Hangzhou, 310006, China
    Gynecol Oncol 94:630-5. 2004
    ..To investigate the expressions of vascular endothelial growth factor (VEGF), VEGFRs and activation of signal transducers and activators of transcription (STATs) in ovarian epithelial carcinoma and the relationships among them...
  28. ncbi Novel role of ARF6 in vascular endothelial growth factor-induced signaling and angiogenesis
    Satoshi Ikeda
    Division of Cardiology, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Circ Res 96:467-75. 2005
    ..Thus, ARF6 is involved in the temporal-spatial organization of caveolae/lipid rafts- and ROS-dependent VEGF signaling in ECs as well as in angiogenesis in vivo...
  29. ncbi Inhibition of human leukemia in an animal model with human antibodies directed against vascular endothelial growth factor receptor 2. Correlation between antibody affinity and biological activity
    Z Zhu
    Department of Antibody Technology, ImClone Systems Incorporated, New York, NY 10014, USA
    Leukemia 17:604-11. 2003
    ..It further underscores the efforts to identify antibodies of high affinity for enhanced antiangiogenic and antitumor activities...
  30. ncbi VEGF(121) and VEGF(165) regulate blood vessel diameter through vascular endothelial growth factor receptor 2 in an in vitro angiogenesis model
    Martin N Nakatsu
    Department of Molecular Biology and Biochemistry, University of California Irvine, Irvine, California 92697, USA
    Lab Invest 83:1873-85. 2003
    ..We conclude that the diameter of new capillary sprouts can be determined by the local concentration of VEGF and that the action of VEGF on angiogenic EC in this assay is critically dependent on signaling through VEGFR-2...
  31. ncbi Anti-PlGF inhibits growth of VEGF(R)-inhibitor-resistant tumors without affecting healthy vessels
    Christian Fischer
    Department for Transgene Technology and Gene Therapy, VIB, 3000, Leuven, Belgium
    Cell 131:463-75. 2007
    ..The efficacy and safety of alphaPlGF, its pleiotropic and complementary mechanism to VEGF(R)Is, and the negligible induction of an angiogenic rescue program suggest that alphaPlGF may constitute a novel approach for cancer treatment...
  32. ncbi Reduced number of circulating endothelial progenitor cells predicts future cardiovascular events: proof of concept for the clinical importance of endogenous vascular repair
    Caroline Schmidt-Lucke
    Molecular Cardiology, Department of Medicine III, J W Goethe University, Frankfurt, Germany
    Circulation 111:2981-7. 2005
    ..Circulating EPCs may thus provide an endogenous repair mechanism to counteract ongoing risk factor-induced endothelial injury and to replace dysfunctional endothelium...
  33. ncbi Angiogenesis is associated with blood-brain barrier permeability in temporal lobe epilepsy
    Valerie Rigau
    Centre National de la Recherche Scientifique UMR5203, Universite Montpellier 1, Universite Montpellier 2, F34094 Montpellier, France
    Brain 130:1942-56. 2007
    ..We suggest that the persistent leakage of serum IgG in the interstitial space and their uptake by neurons may participate in hypoperfusion and in neuronal dysfunction occurring in TLE...
  34. pmc Neuropilin-1 in regulation of VEGF-induced activation of p38MAPK and endothelial cell organization
    Harukiyo Kawamura
    Rudbeck Laboratory, Department of Genetics and Pathology, Uppsala, University, Uppsala, Sweden
    Blood 112:3638-49. 2008
    ..Our data strongly indicate that the ability of VEGF ligands to bind NRP1 influences p38MAPK activation, and formation of functional, pericyte-associated vessels...
  35. ncbi Rapid analysis of angiogenesis drugs in a live fluorescent zebrafish assay
    Laura M Cross
    Arterioscler Thromb Vasc Biol 23:911-2. 2003
  36. ncbi VEGF regulates the mobilization of VEGFR2/KDR from an intracellular endothelial storage compartment
    Alexandra Gampel
    Mammalian Cell Biology Laboratory, Department of Biochemistry, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, United Kingdom
    Blood 108:2624-31. 2006
    ....
  37. ncbi Fasudil-induced hypoxia-inducible factor-1alpha degradation disrupts a hypoxia-driven vascular endothelial growth factor autocrine mechanism in endothelial cells
    Keiko Takata
    Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, 2 2, Yamadaoka, Suita, Osaka 565 0871, Japan
    Mol Cancer Ther 7:1551-61. 2008
    ..In summary, the Rho/ROCK/HIF-1alpha signaling is an essential mechanism for hypoxia-driven, VEGF-mediated autocrine loop in ECs. Therefore, fasudil might have the antimigratory effect against ECs in tumor angiogenesis...
  38. ncbi Neuropilin-1 regulates attachment in human endothelial cells independently of vascular endothelial growth factor receptor-2
    Matilde Murga
    Experimental Transplantation and Immunology Branch, Center for Cancer Research, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 105:1992-9. 2005
    ..Based on its dual role as an enhancer of VEGF activity and a mediator of endothelial cell adhesiveness described here, NRP-1 emerges as a promising molecular target for the development of antiangiogenic drugs...
  39. pmc Wnt signaling promotes hematoendothelial cell development from human embryonic stem cells
    Petter S Woll
    Stem Cell Institute and Department of Medicine, University of Minnesota, Translational Research Facility, 2001 6th St SE, Minneapolis, MN 55455, USA
    Blood 111:122-31. 2008
    ..These studies effectively demonstrate the importance of canonical Wnt signaling to mediate development of early hematoendothelial progenitors during human development...
  40. pmc The vascular endothelial growth factor (VEGF) receptor Flt-1 (VEGFR-1) modulates Flk-1 (VEGFR-2) signaling during blood vessel formation
    David M Roberts
    Program in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill 27599, USA
    Am J Pathol 164:1531-5. 2004
    ....
  41. ncbi IQGAP1, a novel vascular endothelial growth factor receptor binding protein, is involved in reactive oxygen species--dependent endothelial migration and proliferation
    Minako Yamaoka-Tojo
    Division of Cardiology Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Circ Res 95:276-83. 2004
    ....
  42. ncbi Neuropilin-1 binds to VEGF121 and regulates endothelial cell migration and sprouting
    Qi Pan
    Department of Tumor Biology, Genentech, Inc, South San Francisco, California 94080, USA
    J Biol Chem 282:24049-56. 2007
    ..VEGFR2 complex. Additionally, we show that VEGFR2 enhances VEGF(165), but not VEGF(121) binding to NRP1. We propose a new model for NRP1 interactions with various VEGF isoforms...
  43. ncbi Gene expression profile signatures indicate a role for Wnt signaling in endothelial commitment from embryonic stem cells
    Hong Wang
    Carolina Cardiovascular Biology Center, University of North Carolina, Chapel Hill, USA
    Circ Res 98:1331-9. 2006
    ..These data indicate a requisite and ongoing role for Wnt activity during vascular development, and the gene expression profiles identify candidate components of this pathway that participate in vascular cell differentiation...
  44. pmc Substitution of C-terminus of VEGFR-2 with VEGFR-1 promotes VEGFR-1 activation and endothelial cell proliferation
    Rosana D Meyer
    Departments of Ophthalmology and Biochemistry, School of Medicine, Boston University, 715 Albany Street, Boston, MA 02118, USA
    Oncogene 23:5523-31. 2004
    ..Thus, the carboxyl tail of VEGFR-1 restrains the ligand-dependent kinase activation and downregulation of VEGFR-1 and its ability to convey the angiogenic responses in endothelial cells...
  45. pmc Vascular endothelial growth factor receptor 2-mediated angiogenesis is essential for gonadotropin-dependent follicle development
    Ralf C Zimmermann
    Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    J Clin Invest 112:659-69. 2003
    ..We conclude that the intraovarian VEGF/VEGFR-2 pathway is critical for gonadotropin-dependent angiogenesis and follicular development...
  46. ncbi Hypoxia-induced mitogenic factor has proangiogenic and proinflammatory effects in the lung via VEGF and VEGF receptor-2
    Kazuyo Yamaji-Kegan
    Department of Anesthesiology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21205, USA
    Am J Physiol Lung Cell Mol Physiol 291:L1159-68. 2006
    ..Intravenous injection of HIMF also downregulated the expression of VEGFR2 in the lung. These results suggest that HIMF plays critical roles in pulmonary inflammation as well as angiogenesis...
  47. ncbi p38 MAPK inhibition is critically involved in VEGFR-2-mediated endothelial cell survival
    Ali Yilmaz
    Department of Internal Medicine II Cardiology, Ulm University Medical Center, University of Ulm, Robert Koch Str 8, 89081, Ulm, Germany
    Biochem Biophys Res Commun 306:730-6. 2003
    ..These data indicate that activation of VEGFR-2 prevents endothelial cell apoptosis by inhibiting p38 MAPK phosphorylation and thus, reducing caspase-3 activity...
  48. pmc Regulation of Notch1 and Dll4 by vascular endothelial growth factor in arterial endothelial cells: implications for modulating arteriogenesis and angiogenesis
    Zhao Jun Liu
    The Wistar Institute, Philadelphia, Pennsylvania 19104, USA
    Mol Cell Biol 23:14-25. 2003
    ..This study provides the first evidence for regulation of Notch/Delta gene expression by an angiogenic growth factor and insight into the critical role of Notch signaling in arteriogenesis and angiogenesis...
  49. ncbi Microultrasound molecular imaging of vascular endothelial growth factor receptor 2 in a mouse model of tumor angiogenesis
    Joshua J Rychak
    VisualSonics, Inc, Toronto, ON
    Mol Imaging 6:289-96. 2007
    ..A xenograft tumor model in the mouse was used to image vascular endothelial growth factor receptor 2 (VEGFR-2) expression with microbubbles conjugated to an anti-VEGFR-2 monoclonal antibody or an ..
  50. ncbi Polymorphisms of KDR gene are associated with coronary heart disease
    Yibo Wang
    Key Laboratory for Clinical Cardiovascular Genetics, Ministry of Education, China
    J Am Coll Cardiol 50:760-7. 2007
    ..Our purpose was to determine whether the common polymorphisms (SNP-604, SNP1192, and SNP1719) in KDR are associated with risk of coronary heart disease...
  51. ncbi Activated VEGFR2/KDR pathway in tumour cells and tumour associated vessels of colorectal cancer
    A Giatromanolaki
    Tumor and Angiogenesis Research Group, Department of Pathology, Democritus University of Thrace, Alexandroupolis, Greece
    Eur J Clin Invest 37:878-86. 2007
    ..The study of the activation status of VEGF receptors in human malignancies has recently become feasible by means of specific monoclonal antibodies recognising the phosphorylated form of these receptors...
  52. pmc p38 MAPK activity is stimulated by vascular endothelial growth factor receptor 2 activation and is essential for shear stress-induced angiogenesis
    Eric Gee
    School of Kinesiology and Health Science, Muscle Health Research Centre, York University, Toronto, Ontario, Canada
    J Cell Physiol 222:120-6. 2010
    ..We hypothesize that shear stress-dependent activation of vascular endothelial growth factor receptor 2 (VEGFR2) causes p38 and ERK1/2 phosphorylation, which contribute to shear stress-induced ..
  53. ncbi Vascular endothelial growth factor C and vascular endothelial growth factor receptor 2 are related closely to the prognosis of patients with ovarian carcinoma
    Naoyo Nishida
    Department of Pathology, Kurume University School of Medicine, Research Center of Innovative Cancer Therapy of the 21st Century COE Program for Medical Science, Asahi machi, Japan
    Cancer 101:1364-74. 2004
    ..However, the prognostic significance of VEGF and VEGFR expression in ovarian carcinoma is unclear...
  54. ncbi Vascular endothelial growth factor (VEGF)-Receptor2: its biological functions, major signaling pathway, and specific ligand VEGF-E
    Masabumi Shibuya
    Division of Genetics, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    Endothelium 13:63-9. 2006
    ....
  55. pmc Rapid vascular regrowth in tumors after reversal of VEGF inhibition
    Michael R Mancuso
    Cardiovascular Research Institute, Comprehensive Cancer Center, and Department of Anatomy, UCSF, San Francisco, California 94143 0452, USA
    J Clin Invest 116:2610-21. 2006
    ....
  56. pmc Vascular endothelial growth factor-A is a survival factor for retinal neurons and a critical neuroprotectant during the adaptive response to ischemic injury
    Kazuaki Nishijima
    R and D Consultants, Barnet, Herts, UK
    Am J Pathol 171:53-67. 2007
    ..These findings have implications for both neural pathologies and ocular vascular diseases, such as diabetic retinopathy and age-related macular degeneration...
  57. pmc Vascular permeability factor/vascular endothelial growth factor induces lymphangiogenesis as well as angiogenesis
    Janice A Nagy
    Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA
    J Exp Med 196:1497-506. 2002
    ..These findings raise the possibility that similar, abnormal lymphatics develop in other pathologies in which VEGF-A is overexpressed, e.g., malignant tumors and chronic inflammation...
  58. ncbi Vascular endothelial growth factor receptor 2 expression in non-tumorous cirrhotic liver is higher when hepatoma is beyond Milan criteria
    Federico Aucejo
    Liver Transplantation, Cleveland Clinic, Cleveland, OH 44195, USA
    Liver Transpl 15:169-76. 2009
    ..Further investigation is needed to assess the value of angiogenesis modulation in preventing tumor formation and/or progression in cirrhotic patients...
  59. ncbi Angiogenic factors are elevated in overweight and obese individuals
    J V Silha
    Department of Physiology, University of Manitoba, Winnipeg, Canada
    Int J Obes (Lond) 29:1308-14. 2005
    ..Adipose tissue produces both vascular growth factors and inhibitors. Since obesity is associated with expansion of the capillary bed in regional adipose depots the balance between these factors may favor angiogenesis...
  60. ncbi Corneal verticillata after dual anti-epidermal growth factor receptor and anti-vascular endothelial growth factor receptor 2 therapy (vandetanib) for anaplastic astrocytoma
    Steven Yeh
    National Eye Institute and daggerNational Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Cornea 28:699-702. 2009
    ..To describe a patient with a history of epithelial basement membrane dystrophy who developed symptomatic corneal verticillata after vandetanib therapy for anaplastic astrocytoma...
  61. ncbi Vascular endothelial growth factor receptor 2 plays a role in the activation of aortic endothelial cells by oxidized phospholipids
    Alejandro Zimman
    Departments of Medicine, University of California, Los Angeles, CA, USA
    Arterioscler Thromb Vasc Biol 27:332-8. 2007
    ..The present studies identify vascular endothelial growth factor receptor 2 (VEGFR2) as a major regulator in the activation of SREBP and Erk 1/2 in endothelial cells ..
  62. pmc Endogenous VEGF is required for visual function: evidence for a survival role on müller cells and photoreceptors
    Magali Saint-Geniez
    Schepens Eye Research Institute, Harvard Medical School, Boston, Massachusetts, USA
    PLoS ONE 3:e3554. 2008
    ....
  63. ncbi Identification of a novel vascular endothelial growth factor receptor 2 inhibitor and its effect for choroidal neovascularization in vivo
    Hidenori Takahashi
    Department of Ophthalmology, University of Tokyo School of Medicine, Bunkyo ku, Tokyo, Japan
    Curr Eye Res 33:1002-10. 2008
    ..To select a novel orally administered VEGFR-2 (KDR/flk-1) specific tyrosine kinase inhibitor in a murine model of choroidal neovascularization (CNV)...
  64. ncbi Epidermal growth factor receptor and vascular endothelial growth factor receptor 2 are specific biomarkers in triple-negative breast cancer. Results from a controlled randomized trial with long-term follow-up
    Lisa Rydén
    Department of Surgery, Institution of Clinical Sciences, Lund University Hospital, SE 221 85, Lund, Sweden
    Breast Cancer Res Treat 120:491-8. 2010
    ..epidermal receptor growth factor (EGFR), vascular endothelial growth factor A (VEGF-A), and vascular endothelial growth factor receptor 2 (VEGFR2)...
  65. pmc Acetyl-11-keto-beta-boswellic acid inhibits prostate tumor growth by suppressing vascular endothelial growth factor receptor 2-mediated angiogenesis
    Xiufeng Pang
    Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China
    Cancer Res 69:5893-900. 2009
    ..Our findings suggest that AKBA potently inhibits human prostate tumor growth through inhibition of angiogenesis induced by VEGFR2 signaling pathways...
  66. ncbi Expression of vascular endothelial growth factor and its receptors in the central nervous system in amyotrophic lateral sclerosis
    Alice Brockington
    Academic Neurology Unit and the Academic Unit of Pathology, University of Sheffield, Medical School, Sheffield, U K
    J Neuropathol Exp Neurol 65:26-36. 2006
    ....
  67. ncbi Circulating endothelial progenitor cells correlate to stage in patients with invasive breast cancer
    Rakhi P Naik
    Department of Medicine, Division of Hematology Oncology, New York Presbyterian Hospital, Weill Medical College of Cornell University, New York, NY 10021, USA
    Breast Cancer Res Treat 107:133-8. 2008
    ..01). These results suggest that circulating EPCs may serve as a potential tumor biomarker in breast cancer and that EPCs may represent a plausible target for future therapeutic intervention...
  68. ncbi Autocrine VEGF-A/KDR loop protects epithelial ovarian carcinoma cells from anoikis
    Ifat Sher
    Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada
    Int J Cancer 124:553-61. 2009
    ..Our results imply that treating EOC patients with VEGF blocking agents may potentially reduce peritoneal dissemination by decreasing vascular permeability as well as inducing apoptosis of shed ovarian cancer cells in ascites...
  69. ncbi Expression and significance of vascular endothelial growth factor receptor 2 in bladder cancer
    Guangbin Xia
    Department of Medicine, Keck School of Medicine of the University of Southern California, California, USA
    J Urol 175:1245-52. 2006
    ..Therefore, we studied the expression of VEGF and VEGFR2 in bladder cancer, and the relationship to disease characteristics...
  70. ncbi Regulatory role of dynamin-2 in VEGFR-2/KDR-mediated endothelial signaling
    Resham Bhattacharya
    Department of Biochemistry and Molecular Biology, Mayo Clinic Cancer Center, Rochester, Minnesota 55905, USA
    FASEB J 19:1692-4. 2005
    ..Taken together, our findings suggest that dynamin-2 regulates KDR expression and function and hence plays an important role in VPF/VEGF mediated angiogenesis...
  71. ncbi Vascular normalization by vascular endothelial growth factor receptor 2 blockade induces a pressure gradient across the vasculature and improves drug penetration in tumors
    Ricky T Tong
    Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Cancer Res 64:3731-6. 2004
    ..Thus, vascular normalization may contribute to the improved survival rates in tumor-bearing animals and in colorectal carcinoma patients treated with an anti-VEGF antibody in combination with cytotoxic therapies...
  72. ncbi VEGF-dependent plasticity of fenestrated capillaries in the normal adult microvasculature
    Tomomi Kamba
    Cardiovascular Research Institute, and Dept of Anatomy, Univ of California, 513 Parnassus Ave, San Francisco, CA 94143 0452, USA
    Am J Physiol Heart Circ Physiol 290:H560-76. 2006
    ..Our findings of VEGF dependency of normal fenestrated capillaries and rapid regrowth after regression demonstrate the plasticity of the adult microvasculature...
  73. ncbi Rationale for antiangiogenic cancer therapy with vaccination using epitope peptides derived from human vascular endothelial growth factor receptor 2
    Satoshi Wada
    Department of Surgery and Bioengineering, Advanced Clinical Research Center, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    Cancer Res 65:4939-46. 2005
    ..tumor angiogenesis can also be inhibited if cellular immune response could be induced against vascular endothelial growth factor receptor 2 (VEGFR2), which is one of the key factors in tumor angiogenesis...
  74. ncbi Relationship between retention of a vascular endothelial growth factor receptor 2 (VEGFR2)-targeted ultrasonographic contrast agent and the level of VEGFR2 expression in an in vivo breast cancer model
    Debbie J Lee
    Harvard Medical School, Boston, Massachusetts, USA
    J Ultrasound Med 27:855-66. 2008
    The aim of this study was to characterize the relationship between retention of a vascular endothelial growth factor receptor 2 (VEGFR2)-targeted ultrasonographic contrast agent (UCA) and VEGFR2 expression in tumor vasculature of breast ..
  75. pmc Vascular endothelial-cadherin tyrosine phosphorylation in angiogenic and quiescent adult tissues
    Nathalie Lambeng
    INSERM, CEA, Université J Fourier EMI 02 19, Laboratoire de Développement et Vieillissement de l Endothélium, Grenoble, France
    Circ Res 96:384-91. 2005
    ..Physical association between Flk1, Src, and VE-cadherin may thus provide an efficient mechanism for amplification and perpetuation of VEGF-stimulated angiogenic processes...
  76. ncbi VEGF receptor signal transduction
    Xiujuan Li
    Uppsala University, Department of Genetics and Pathology, Rudbeck Laboratory, Uppsala, Sweden
    Methods Enzymol 443:261-84. 2008
    ..We emphasize the need for validation of in vitro data in more complex models, where endothelial cells reside in their proper three-dimensional context...
  77. ncbi Vascular endothelial growth factor-dependent down-regulation of Flk-1/KDR involves Cbl-mediated ubiquitination. Consequences on nitric oxide production from endothelial cells
    Martine Duval
    Laboratory of Endothelial Cell Biology, Institut de recherches cliniques de Montreal IRCM, Quebec H2W 1R7, Canada
    J Biol Chem 278:20091-7. 2003
    ..Cbl thus plays a role in the regulation of VEGF signaling by mediating the stimulated ubiquitination and, consequently, degradation of Flk-1 in endothelial cells...
  78. ncbi Decursin and decursinol angelate inhibit VEGF-induced angiogenesis via suppression of the VEGFR-2-signaling pathway
    Myung Hwan Jung
    Department of Natural Sciences, School of Life Sciences and Biotechnology, Kyungpook National University, Daegu 702 701, Republic of Korea
    Carcinogenesis 30:655-61. 2009
    ..Taken together, these results demonstrate that decursin and decursinol angelate are novel candidates for inhibition of VEGF-induced angiogenesis...
  79. ncbi Intrinsic versus microenvironmental regulation of lymphatic endothelial cell phenotype and function
    Tanja Veikkola
    Molecular Cancer Biology Laboratory and Ludwig Institute for Cancer Research, Biomedicum Helsinki, Haartman Institute and Helsinki University Central Hospital, 00014 University of Helsinki, Finland
    FASEB J 17:2006-13. 2003
    ..Collectively, these data show intrinsic cell-specific differences of BEC and LEC responses to VEGFs and identify a pericellular regulatory mechanism for VEGFR-3 down-regulation in endothelial cells...
  80. ncbi Signal transduction via vascular endothelial growth factor (VEGF) receptors and their roles in atherogenesis
    Taro Matsumoto
    Division of Cell Regeneration and Transplantation, Advanced Medical Research Center, Nihon University School of Medicine, Tokyo, Japan
    J Atheroscler Thromb 13:130-5. 2006
    ..These phosphorylation sites may be useful targets for the development of anti-angiogenic therapies to treat atherosclerosis and cancer...
  81. ncbi Blocking neuropilin-2 function inhibits tumor cell metastasis
    Maresa Caunt
    Tumor Biology and Angiogenesis, Genentech, Inc, South San Francisco, CA 94080, USA
    Cancer Cell 13:331-42. 2008
    ..Our results demonstrate that Nrp2, which was originally identified as an axon-guidance receptor, is an attractive target for modulating metastasis...
  82. pmc Dimerization of VEGF receptors and implications for signal transduction: a computational study
    Feilim Mac Gabhann
    Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Biophys Chem 128:125-39. 2007
    ..These results have significant implications for VEGF signal transduction and interpretation of experimental studies. These results may be applicable to other ligand-receptor pairs, in particular PDGF...
  83. pmc Gambogic acid inhibits angiogenesis and prostate tumor growth by suppressing vascular endothelial growth factor receptor 2 signaling
    Tingfang Yi
    Center for Cancer and Stem Cell Biology, Institute for Bioscience and Technology, Texas A and M University System Health Science Center, Houston, TX 77030, USA
    Cancer Res 68:1843-50. 2008
    ..Furthermore, we showed that GA inhibited the activations of vascular endothelial growth factor receptor 2 and its downstream protein kinases, such as c-Src, focal adhesion kinase, and AKT...
  84. ncbi Minimal contribution of marrow-derived endothelial precursors to tumor vasculature
    Bruno Larrivee
    Department of Medicine, University of British Columbia, Canada
    J Immunol 175:2890-9. 2005
    ..Furthermore, we show that VEGF-A stimulation of hemopoietic cells does not significantly alter this process...
  85. pmc Precancerous stem cells can serve as tumor vasculogenic progenitors
    Rulong Shen
    Department of Pathology and Comprehensive Cancer Center, Ohio State University, Columbus, Ohio, USA
    PLoS ONE 3:e1652. 2008
    ..Our studies indicate that pCSCs can serve as tumor vasculogenic stem/progenitor cells (TVPCs), and may explain why anti-angiogenic cancer therapy trials are facing challenge...
  86. pmc HoxB5 is an upstream transcriptional switch for differentiation of the vascular endothelium from precursor cells
    Yaxu Wu
    Carolina Cardiovascular Biology Center, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Mol Cell Biol 23:5680-91. 2003
    ..HoxB5 is necessary and sufficient to activate the cell-intrinsic events that regulate the differentiation of angioblasts and mature endothelial cells from their mesoderm-derived precursors...
  87. ncbi Wnt2 acts as a cell type-specific, autocrine growth factor in rat hepatic sinusoidal endothelial cells cross-stimulating the VEGF pathway
    Diana Klein
    Department of Dermatology, Venereology, and Allergology, University Medical Center Mannheim, University of Heidelberg, Mannheim, Germany
    Hepatology 47:1018-31. 2008
    ..Inhibition of Wnt signaling down-regulated VEGFR-2 messenger RNA and protein. Wnt2 siRNA knock-down confirmed Wnt2 specificity of VEGFR-2 regulation in HSECs...
  88. ncbi Inhibition of VEGFR-3 activation with the antagonistic antibody more potently suppresses lymph node and distant metastases than inactivation of VEGFR-2
    Nicole Roberts
    Department of Oncological Sciences, Mount Sinai School of Medicine, New York, New York 10029, USA
    Cancer Res 66:2650-7. 2006
    ....
  89. ncbi Vascular endothelial growth factor and its receptor, Flk-1/KDR, are cytoprotective in the extravascular compartment of the ovarian follicle
    James Greenaway
    Department of Biomedical Sciences, University of Guelph, Guelph, Ontario, Canada N1G 2W1
    Endocrinology 145:2896-905. 2004
    ..The results of this study demonstrate for the first time expression of Flk-1/KDR in ovarian granulosa cells and identify a novel extravascular role for VEGF and its receptor in ovarian function...
  90. ncbi Vascular and haematopoietic stem cells: novel targets for anti-angiogenesis therapy?
    Shahin Rafii
    Division of Hematology Oncology, Cornell University Medical College, 1300 York Avenue, Room D601, New York, New York 10021, USA
    Nat Rev Cancer 2:826-35. 2002
  91. ncbi Vascular density and distribution of vascular endothelial growth factor (VEGF) and its receptor VEGFR-2 (Flk-1) are significantly higher in patients with deeply infiltrating endometriosis affecting the rectum
    Daniel Escorsim Machado
    Department of Histology and Embryology, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil
    Fertil Steril 90:148-55. 2008
    ....
  92. ncbi Role of VEGF family members and receptors in coronary vessel formation
    Robert J Tomanek
    Department of Anatomy, University of Iowa, Iowa City, Iowa 52242, USA
    Dev Dyn 225:233-40. 2002
    ..In summary, these experiments document a role for multiple members of the VEGF family and their receptors in formation of the coronary vascular bed...
  93. ncbi Phosphorylated KDR can be located in the nucleus of neoplastic cells
    Cristina Blazquez
    Departamento de Bioquimica y Biologia Molecular I, Facultad de Biologia, Universidad Complutense de Madrid, Ciudad Universitaria, Madrid 28040, Espania, Spain
    Cell Res 16:93-8. 2006
    ..We conclude that neoplastic cells show a variable expression of total and phosphorylated KDR in the nucleus. The precise functional meaning of nuclear location remains to be established...
  94. ncbi Generalised reduction of putative endothelial progenitors and CXCR4-positive peripheral blood cells in type 2 diabetes
    C G Egan
    Department of Neuroscience, University of Siena, Via A Moro, 53100, Siena, Italy
    Diabetologia 51:1296-305. 2008
    ..Since expression of chemokine (C-X-C motif) receptor 4 (CXCR4) has been associated with mobilisation and recruitment of progenitor cells, CXCR4 expression was also analysed...
  95. ncbi VEGF-D is the strongest angiogenic and lymphangiogenic effector among VEGFs delivered into skeletal muscle via adenoviruses
    Tuomas T Rissanen
    Department of Biotechnology and Molecular Medicine, A I Virtanen Institute, University of Kuopio, PO Box 1627, FIN 70211 Kuopio, Finland
    Circ Res 92:1098-106. 2003
    ..This study compares, for the first time, angiogenesis and lymphangiogenesis induced by gene transfer of different human VEGFs, and shows that VEGF-D is the most potent member when delivered via an adenoviral vector into skeletal muscle...
  96. ncbi Sirolimus for Kaposi's sarcoma in renal-transplant recipients
    Giovanni Stallone
    Division of Nephrology, Department of Emergency and Transplantation, University of Bari, Bari, Italy
    N Engl J Med 352:1317-23. 2005
    ..Recipients of organ transplants are susceptible to Kaposi's sarcoma as a result of treatment with immunosuppressive drugs. Sirolimus (rapamycin), an immunosuppressive drug, may also have antitumor effects...
  97. ncbi Development of angiogenesis inhibitors to vascular endothelial growth factor receptor 2. Current status and future perspective
    Keren Paz
    Department of Antibody Technology, ImClone Systems Incorporated, New York, NY 10014, USA
    Front Biosci 10:1415-39. 2005
    ..The attempts to develop effective KDR antagonists, including small molecules, antibodies and others, for therapeutic purposes are discussed comprehensively with special emphasis on tumor angiogenesis...
  98. pmc Cochlear pericyte responses to acoustic trauma and the involvement of hypoxia-inducible factor-1alpha and vascular endothelial growth factor
    Xiaorui Shi
    Department of Otolaryngology and Head and Neck Surgery, Oregon Hearing Research Center, Oregon Health and Science University, Portland, Oregon 97239 3098, USA Institute of Microcirculation, Chinese Academy of MedicalSciences CAMS and Peking Union Medical College PUMC, 5 Dong Dan San Tiao, Beijing, 100005, China
    Am J Pathol 174:1692-704. 2009
    ..HIF-1alpha activation and VEGF up-regulation are important factors for the alteration of the pericyte structural protein desmin...
  99. ncbi Enhancement of vascular progenitor potential by protein kinase A through dual induction of Flk-1 and Neuropilin-1
    Kohei Yamamizu
    Laboratory of Stem Cell Differentiation, Stem Cell Research Center, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan
    Blood 114:3707-16. 2009
    ..This new-mode mechanism regulating "progenitor sensitivity" would provide a novel understanding in vascular development and regeneration...
  100. ncbi VEGF-A promotes tissue repair-associated lymphatic vessel formation via VEGFR-2 and the alpha1beta1 and alpha2beta1 integrins
    Young Kwon Hong
    Cutaneous Biology Research Center, Department of Dermatology, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    FASEB J 18:1111-3. 2004
    ....
  101. ncbi A comparative study of gene vaccines encoding different extracellular domains of the vascular endothelial growth factor receptor 2 in the mouse model of colon adenocarcinoma CT-26
    Jian Dong
    Biotherapy Center, First Affiliated Hospital of Kunming Medical College, Kunming, Yunnan, China
    Cancer Biol Ther 7:502-9. 2008
    ..To compare the immunogenicity and anti-tumor effects of gene vaccines encoding domains 1-4 with full length of extracellular region of VEGFR2...

Research Grants63

  1. REGULATION OF VEGF EXPRESSION IN PLACENTA AND MEMBRANES
    CECILIA CHEUNG; Fiscal Year: 2004
    ..Results from these studies will promote understanding of amniotic fluid volume regulation, and provide important information for diagnosis and management of amniotic fluid disorders in human pregnancy. ..
  2. Evaluating Novel Multi-kinase Peptide Inhibitors as a Treatment for Rheumatoid Ar
    DAVID MEN HWEI TSAI; Fiscal Year: 2013
    ..AX-3) that inhibits the tyrosine kinase activity of epidermal growth factor receptor (EGFR), vascular endothelial growth factor receptor 2 (VEGFR2), and insulin receptor (IR)...
  3. Nitric Oxide in Tumor Angiogenesis, Microcirculation and Radiation Therapy
    Dai Fukumura; Fiscal Year: 2012
    ..Recent results show that blockade of vascular endothelial growth factor receptor 2 (VEGFR2) transiently improves perivascular cell coverage, tissue oxygenation and response to ..
  4. Functional characterization of a novel adult renal progenitor cell population
    TROY D CAMARATA; Fiscal Year: 2011
    ..This new information will aid in the development of novel therapies for acute and chronic forms of kidney disease and will provide critical information to the fields of renal biology as well as organ regeneration. ..
  5. Role of Syntaxin 6 Regulated Post-Golgi Trafficking in Angiogenesis
    Amit Choudhury; Fiscal Year: 2012
    ..By studying and understanding the trafficking of angiogenesis-regulatory molecules, we may identify a novel target for therapy. ..
  6. Activation and Signaling Mechanism of the RET Tyrosine Kinase Receptor
    JENNIFER MARIE CHOW; Fiscal Year: 2013
    ..3) The mechanisms and impact of crosstalk between RET and vascular endothelial growth factor receptor 2 (VEGFR2) will be explored, to establish at what levels in RET signaling crosstalk occurs and ..
  7. Engineering Stem Cell Niches to Guide Differentiation
    DANIELLE A TSOU; Fiscal Year: 2011
    ..The hematopoietic differentiation pathways in the murine system have been established, and a specific ESC line will allow simultaneous monitoring of mesoderm and hematopoietic differentiation. ..
  8. Pericyte-endothelial cross talk in vascular stability after kidney injury
    STUART JAMES SHANKLAND; Fiscal Year: 2013
    ..New studies have identified pericyte to endothelial signaling via Vascular Endothelial Growth Factor Receptor 2 (VEGFR2) as a central pathway in regulating pericyte detachment and kidney disease progression...
  9. Molecular Ultrasound for Early Breast Cancer Detection
    JUERGEN KARL WILLMANN; Fiscal Year: 2013
    ..Based on successful study results, we anticipate rapid translation of this technique into the clinic to improve patient survival and patient care by diagnosing breast cancer at an earlier stage. ..
  10. Molecular insights into the pathogenesis of Sorsby Fundus Dystrophy
    Jian Hua Qi; Fiscal Year: 2013
    ..Undoubtedly, this would provide novel insights into the pathogenesis of SFD and ARMD that share similar disease phenotype, and thereby establish a potential therapeutic target for these ocular diseases. ..
  11. New Strategies for Photoimmunodetection/therapy
    MARK DAVID SAVELLANO; Fiscal Year: 2010
    ..These receptors are ideal targets for PID/PIT since they are often overexpressed and/or overactivated in many cancers, especially aggressive high-risk breast cancers. ..
  12. KDR--A NOVEL FUNCTIONAL HEMATOPOIETIC STEM CELL MARKER
    Cesare Peschle; Fiscal Year: 2004
    ..b>Vascular endothelial growth factor receptor 2 (VEGFR2, Flk1 in mouse and KDR in men) is a key functional marker in embyronic ..
  13. VEGF PROTECTS AGAINST PULMONARY VASCULAR REMODELING
    Rubin Tuder; Fiscal Year: 2001
    ....
  14. Effect of HIV Tat on endothelial cell function
    Lance Terada; Fiscal Year: 2007
    ..The broad objectives of this grant are to further define the nature and significance of Tat dependent oxidant signaling through Hic-5 and EG-1 in endothelial cells. ..
  15. EFFECTS OF STATINS ON PULMONARY HYPERTENSION
    Reda Girgis; Fiscal Year: 2007
    ..This award will allow the candidate to develop into a well-trained independent researcher in PH. ..
  16. Ethanol, Tat and the Blood-brain barrier
    Kwang Kim; Fiscal Year: 2004
    ..e., nitric oxide and signaling pathways. The information derived from this proposal should enhance our understanding of the role of ethanol in HIV-1 neuropthogenesis. ..
  17. PROTEIN SCAFFOLDS FOR DESIGN OF NOVEL ANTICANCER AGENTS
    Brent Kreider; Fiscal Year: 2000
    ..The identification of alternate scaffolds of defined and highly constrained structure for selection of antibody mimics will also be useful for small molecule drug design. ..
  18. Novel Single, Dual and Multitargeted Inhibitors of RTKs
    Aleem Gangjee; Fiscal Year: 2007
    ..abstract_text> ..
  19. Alpha Folate Receptor Mediated GARFTase Inhibitors as Selective Antitumor Agents
    Aleem Gangjee; Fiscal Year: 2010
    ....
  20. STRUCTURE BASED ANALOGS AS ANTIOPPORTUNISTIC AGENTS
    Aleem Gangjee; Fiscal Year: 2001
    ..The analogues synthesized will also be submitted for screening against tuberculosis (NIAID) parasitic diseases (WHO) and tumor cells in culture (NCI). ..
  21. NOVEL NONINDUCIBLE THYMIDYLATE SYNTHASE INHIBITORS
    Aleem Gangjee; Fiscal Year: 2004
    ....
  22. Third Generation Antiopportunistic Agents
    Aleem Gangjee; Fiscal Year: 2003
    ..Screening against tuberculosis (NIAID) and tumor cells in culture (NCI) is also proposed. ..
  23. Novel, P. jirovecii Specific Antipneumocystis Agents
    Aleem Gangjee; Fiscal Year: 2009
    ..These agents could be used alone or in combination to treat PCP thus providing novel agents against a new target. ..
  24. Antitumor Antimitotics That Reverse Tumor Resistance
    Aleem Gangjee; Fiscal Year: 2010
    ..The study will also further define the mechanism of action of the novel series and could afford agents for clinical use. ..
  25. Single Agents with Designed Combination Chemotherapy Potential
    Aleem Gangjee; Fiscal Year: 2010
    ..abstract_text> ..
  26. Assessing Circulating Progenitor Cells in Heart Disease
    Thomas Povsic; Fiscal Year: 2007
    ..This study will look at two methods of measuring these stem cells in the blood of heart patients. These methods may someday be used to predict who will or will not develop heart disease or other complications. ..
  27. Role of Protein Ubiquitination in Angiogenesis
    Nader Rahimi; Fiscal Year: 2010
    ..Identification of molecules that inhibit the angiogenic signaling of VEGFR-2 will provide new avenues for development of better and more effective agents to combat angiogenesis-associated diseases. ..
  28. VEGFR-1 and VEGFR-2 in angiogenesis
    Nader Rahimi; Fiscal Year: 2006
    ..Once we determine the mechanism by which VEGF receptors are engaged it will be possible to attenuate the angiogenic signal transduction relay by developing targeted therapeutic interventions aimed at angiogenesis suppression ..
  29. Anti-angiogenic signaling molecules in retinal cells
    Nader Rahimi; Fiscal Year: 2004
    ..our long-term goal is to begin to apply the information obtained from this project to the design of strategies to regulate angiogenesis in clinical settings. ..
  30. Targeted Delivery of Anthrax Inhibitors
    Marina Backer; Fiscal Year: 2007
    ..In Phase II we will develop LFn-liposomes with combination of LF and EF inhibitors, validate these liposomes in animal models of anthrax infection, and pre-clinical steps required for IND filing. [unreadable] [unreadable] [unreadable]..
  31. Receptor Tyrosine Kinases in Mechanotransduction
    Zheng Gen Jin; Fiscal Year: 2009
    ..In a proteomic search for potential mediators of eNOS activation, we identified vascular endothelial growth factor receptor 2 (VEGFR2) as being involved in laminar flow-induced eNOS activation...
  32. VEGF and Nitric Oxide in Lung Vascular Development
    Vivek Balasubramaniam; Fiscal Year: 2007
    ..In addition, Dr. Balasubramaniam will continue to work with Dr. Charles Plopper (UC Davis) to learn more sophisticated techniques of morphometric analysis. ..
  33. Role of BMDCs in Solid Tumor Growth and Relapse
    Rakesh K Jain; Fiscal Year: 2010
    ..Furthermore, our results will offer strategies for the inhibition of tumor relapse after radiotherapy by targeting molecular pathways that are critical for both angiogenesis and myeloid BMDC recruitment. ..
  34. Fra-1: A new target for a genomic breast cancer vaccine
    Ralph Reisfeld; Fiscal Year: 2009
    ..This allows for this vaccine to go full circle in evaluation from bench to bedside and back for further improvement. ..
  35. Targeting GRP78/BIP As An Adjunct Therapy For EGFR-positive Breast Cancer
    Marina Backer; Fiscal Year: 2008
    ..We expect that this data establish feasibility of clinical development for EGF-SLiP. [unreadable] [unreadable] [unreadable]..
  36. Integrative Biology of Tumor Metastasis
    Rakesh Jain; Fiscal Year: 2009
    ..Finally, we have the resources and the clinical collaborators in place to initiate a clinical trial based on our findings, as attested by our ongoing trial using a VEGF-specific antibody. ..
  37. Therapy of thrombocytopenic disorders by chemokines
    Shahin Rafii; Fiscal Year: 2007
    ..being evaluated in phase I clinical trials, would provide the platform for assessing the role of these agents in amelioration and rapid restoration of thrombocytopenia Induced by chemotherapy and irradiation [unreadable] [unreadable]..
  38. CHRONIC LUNG INJURY AFTER PREMATURE BIRTH
    Richard Bland; Fiscal Year: 2003
    ....
  39. CHEMOKINE RECEPTORS AND ITP AND HIV THROMBOCYTOPE
    Shahin Rafii; Fiscal Year: 2002
    ..Modulation of chemokine receptors expression by adenoviral vectors overexpressing SDF1, ECDF1 or their receptors may allow for developing therapies to ameliorate thrombocytopenia in vivo. ..
  40. TGF BETA AND BRAIN TUMORS
    Jeremy Rich; Fiscal Year: 2002
    ....
  41. NOVEL STRATEGIES FOR THE IMMUNOTHERAPY OF COLON CANCER
    Ralph Reisfeld; Fiscal Year: 2003
    ..The achievement of this proposal's objectives should lead to the design of effective DNA vaccines based on rational immunological principles that may ultimately lead to the improved treatment of colon cancer. ..
  42. The Roles of Osteonectin and Osteoactivin in Gliomas
    Jeremy Rich; Fiscal Year: 2007
    ..2) Validate osteonectin and osteoactivin as potential therapeutic targets in glioma invasion. It is hoped that these studies will provide the basis of novel therapeutic interventions for patients with malignant gliomas. ..
  43. Anti-Angiogenesis/Drugs in Tumors--Bench /Bedside & Back
    Rakesh Jain; Fiscal Year: 2005
    ..Attendance at this conference will provide an excellent opportunity for young investigators working on cancer to educate and familiarize themselves with the field of angiogenesis and the complexities of the system. ..
  44. Vascular Heterogeneity Determination by Marrow Progenit*
    Shahin Rafii; Fiscal Year: 2006
    ..These studies will lay the foundation for using BM-marrow derived cells for therapeutic cell therapy to enhance organ (i.e. lung, marrow) revascularization. ..
  45. Phase I Clinical Trials of Anti-Cancer Agents
    Francis Giles; Fiscal Year: 2007
    ..abstract_text> ..
  46. Conference on Angiogenesis in Cancer and Other Diseases
    Rakesh Jain; Fiscal Year: 2002
    ..The meeting's synthesis of available information will be particularly thought-provoking for students and post- doctoral fellows. ..
  47. VASCULOGENESIS IN THE MURINE ALLANTOIS
    KAREN DOWNS; Fiscal Year: 2002
    ..Further, results of our experiments will shed light on the mechanism of formation of the endothelial cell lineage. ..
  48. Reactive Oxygen Species and Endothelial Migration
    Masuko Ushio Fukai; Fiscal Year: 2010
    ..abstract_text> ..
  49. Endothelial Akt in Vascular Injury
    James Liao; Fiscal Year: 2009
    ..Three specific aims are proposed, which will study the role of endothelial Akt in models of vascular injury and atherosclerosis. ..
  50. Farnesyltransferase Inhibitor Therapy for Myelodysplasia
    Razelle Kurzrock; Fiscal Year: 2002
    ....
  51. Phase II Trial of Tetrathiomolybdate in Prostate Cancer
    David Smith; Fiscal Year: 2002
    ..The levels of these growth factors/cytokines will then be correlated with the degree of copper depletion, PSA level and response to therapy. ..
  52. Human Endometrial Nitric Oxide: Regulation and Function
    Omid Khorram; Fiscal Year: 2003
    ..This pilot study should shed light on regulation and function of human endometrial NO pathway, an uninvestigated area of research with profound clinical significance. ..
  53. RADIATION AND DRUG EFFECTS ON TUMOR CELL SUBPOPULATIONS
    Dietmar Siemann; Fiscal Year: 2001
    ..Ultimately we hope that these approaches can be reliably developed to an extent where the use of human tumor biopsy material may lead to radiotherapy treatments more tailored to the individual patient. ..
  54. In Vivo Potential of Human ES Cell-Derived Blood Cells
    DAN KAUFMAN; Fiscal Year: 2004
    ..abstract_text> ..
  55. Integrins and bone matrix in prostate cancer
    Tatiana Byzova; Fiscal Year: 2006
    ..abstract_text> ..
  56. Targeting Vasculogenesis and Interstitial Hypertension in Neurofibromatosis Type1
    Ugur Ozerdem; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  57. Regulation of Coronary Vessel Assembly and Growth
    Robert Tomanek; Fiscal Year: 2007
    ..Since cardiac development depends on timely and adequate vascularization, an understanding of coronary vasculogenesis and angiogenesis will provide an important foundation for our understanding of cardiac defects. ..
  58. LIVER REGENERATION AS A MODEL FOR ANGIOGENESIS
    Donna Stolz; Fiscal Year: 2008
    ..abstract_text> ..
  59. IN VIVO IMAGING OF FORMATION OF HEPATIC METASTASES
    Jonathan Kruskal; Fiscal Year: 2002
    ..This project will allow identification of a series of in vivo steps that can be used to explore novel diagnostic and therapeutic probes in animal studies. ..
  60. Atheroprotection with Anti-angiogenic DNA Vaccines
    RAMONA PETROVAN; Fiscal Year: 2006
    ..Achievement of this proposal's objectives should lead to the development of highly efficient anti-atherosclerotic therapies that will greatly improve future treatment choices for atherosclerosis. ..
  61. Endothelial Transmigration Across the RPE Barrier
    Mary Elizabeth Hartnett; Fiscal Year: 2005
    ..Increased knowledge of the mechanisms that cause this destructive phenomenon may lead to future means to prevent CNV in the neurosensory retina, and thus, reduce vision loss in AMD. ..
  62. Cyclic Follicle Function and Angiogenesis
    Ralf Zimmermann; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  63. LPS-PEPTIDE INTERACTION IN BLADDER INFLAMMATION
    Ricardo Saban; Fiscal Year: 2007
    ..Information generated by this study should elucidate whether bladder inflammatory responses, regardless of etiology, occur via a common mechanism or whether the endpoints are specific for each stimulus. ..