vascular endothelial growth factor receptor 1

Summary

Summary: A 180-kDa VEGF receptor found primarily in endothelial cells that is essential for vasculogenesis and vascular maintenance. It is also known as Flt-1 (fms-like tyrosine kinase receptor-1). A soluble, alternatively spliced isoform of the receptor may serve as a binding protein that regulates the availability of various ligands for VEGF receptor binding and signal transduction.

Top Publications

  1. pmc Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia
    Sharon E Maynard
    Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02115, USA
    J Clin Invest 111:649-58. 2003
  2. ncbi Circulating angiogenic factors and the risk of preeclampsia
    Richard J Levine
    Division of Epidemiology, Statistics, and Prevention Research, National Institute of Child Health and Human Development, Department of Health and Human Services, Bethesda, MD 20892, USA
    N Engl J Med 350:672-83. 2004
  3. pmc VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche
    Rosandra N Kaplan
    Department of Pediatrics and the Children s Blood Foundation Laboratories, Weill Cornell Medical College of Cornell University, New York, New York 10021, USA
    Nature 438:820-7. 2005
  4. ncbi Soluble endoglin contributes to the pathogenesis of preeclampsia
    Shivalingappa Venkatesha
    Center for Vascular Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, Boston, Massachusetts 02215, USA
    Nat Med 12:642-9. 2006
  5. ncbi Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium
    G H Fong
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    Nature 376:66-70. 1995
  6. ncbi Soluble endoglin and other circulating antiangiogenic factors in preeclampsia
    Richard J Levine
    Division of Epidemiology, Statistics, and Prevention Research, National Institute of Child Health and Human Development, Department of Health and Human Services, Bethesda, MD 20892, USA
    N Engl J Med 355:992-1005. 2006
  7. pmc Flt-1 lacking the tyrosine kinase domain is sufficient for normal development and angiogenesis in mice
    S Hiratsuka
    Department of Genetics, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Proc Natl Acad Sci U S A 95:9349-54. 1998
  8. ncbi Revascularization of ischemic tissues by PlGF treatment, and inhibition of tumor angiogenesis, arthritis and atherosclerosis by anti-Flt1
    Aernout Luttun
    Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, University of Leuven, Leuven, Belgium
    Nat Med 8:831-40. 2002
  9. ncbi Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene
    N Ferrara
    Department of Cardiovascular Research, Genentech Inc, South San Francisco, California 94080, USA
    Nature 380:439-42. 1996
  10. ncbi Anti-flt1 peptide, a vascular endothelial growth factor receptor 1-specific hexapeptide, inhibits tumor growth and metastasis
    Dong Goo Bae
    Department of Life Science, Division of Molecular and Life Sciences, Postech Biotech Center, Pohang University of Science and Technology, Pohang, Korea
    Clin Cancer Res 11:2651-61. 2005

Detail Information

Publications244 found, 100 shown here

  1. pmc Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia
    Sharon E Maynard
    Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02115, USA
    J Clin Invest 111:649-58. 2003
    ..These observations suggest that excess circulating sFlt1 contributes to the pathogenesis of preeclampsia...
  2. ncbi Circulating angiogenic factors and the risk of preeclampsia
    Richard J Levine
    Division of Epidemiology, Statistics, and Prevention Research, National Institute of Child Health and Human Development, Department of Health and Human Services, Bethesda, MD 20892, USA
    N Engl J Med 350:672-83. 2004
    ..Limited data suggest that excess circulating soluble fms-like tyrosine kinase 1 (sFlt-1), which binds placental growth factor (PlGF) and vascular endothelial growth factor (VEGF), may have a pathogenic role...
  3. pmc VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche
    Rosandra N Kaplan
    Department of Pediatrics and the Children s Blood Foundation Laboratories, Weill Cornell Medical College of Cornell University, New York, New York 10021, USA
    Nature 438:820-7. 2005
    ..Here we demonstrate that bone marrow-derived haematopoietic progenitor cells that express vascular endothelial growth factor receptor 1 (VEGFR1; also known as Flt1) home to tumour-specific pre-metastatic sites and form cellular ..
  4. ncbi Soluble endoglin contributes to the pathogenesis of preeclampsia
    Shivalingappa Venkatesha
    Center for Vascular Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, Boston, Massachusetts 02215, USA
    Nat Med 12:642-9. 2006
    ..Our results suggest that sEng may act in concert with sFlt1 to induce severe preeclampsia...
  5. ncbi Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium
    G H Fong
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    Nature 376:66-70. 1995
    ..We suggest that the Flt-1 signalling pathway may regulate normal endothelial cell-cell or cell-matrix interactions during vascular development...
  6. ncbi Soluble endoglin and other circulating antiangiogenic factors in preeclampsia
    Richard J Levine
    Division of Epidemiology, Statistics, and Prevention Research, National Institute of Child Health and Human Development, Department of Health and Human Services, Bethesda, MD 20892, USA
    N Engl J Med 355:992-1005. 2006
    ..Since soluble endoglin, another antiangiogenic protein, acts together with sFlt1 to induce a severe preeclampsia-like syndrome in pregnant rats, we examined whether it is associated with preeclampsia in women...
  7. pmc Flt-1 lacking the tyrosine kinase domain is sufficient for normal development and angiogenesis in mice
    S Hiratsuka
    Department of Genetics, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Proc Natl Acad Sci U S A 95:9349-54. 1998
    ..These results indicate that Flt-1 without tyrosine kinase domain is sufficient to allow embryonic development with normal angiogenesis, and that a receptor tyrosine kinase plays a main biological role as a ligand-binding molecule...
  8. ncbi Revascularization of ischemic tissues by PlGF treatment, and inhibition of tumor angiogenesis, arthritis and atherosclerosis by anti-Flt1
    Aernout Luttun
    Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, University of Leuven, Leuven, Belgium
    Nat Med 8:831-40. 2002
    ..Thus, PlGF and Flt1 constitute potential candidates for therapeutic modulation of angiogenesis and inflammation...
  9. ncbi Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene
    N Ferrara
    Department of Cardiovascular Research, Genentech Inc, South San Francisco, California 94080, USA
    Nature 380:439-42. 1996
    ..Angiogenesis and blood-island formation were impaired, resulting in several developmental anomalies. Furthermore, VEGF-null embryonic stem cells exhibit a dramatically reduced ability to form tumours in nude mice...
  10. ncbi Anti-flt1 peptide, a vascular endothelial growth factor receptor 1-specific hexapeptide, inhibits tumor growth and metastasis
    Dong Goo Bae
    Department of Life Science, Division of Molecular and Life Sciences, Postech Biotech Center, Pohang University of Science and Technology, Pohang, Korea
    Clin Cancer Res 11:2651-61. 2005
    The purpose of this study was to develop antagonists specific for the vascular endothelial growth factor receptor 1 (VEGFR1) and to investigate the effects of the antagonists on the VEGF-induced endothelial cell functions and tumor ..
  11. ncbi VEGF receptor protein-tyrosine kinases: structure and regulation
    Robert Roskoski
    Blue Ridge Institute for Medical Research, 3754 Brevard Road, Suite 116A, Box 19, Horse Shoe, NC 28742, USA
    Biochem Biophys Res Commun 375:287-91. 2008
    ..Interaction between VEGFR1 and VEGFR2 or VEGFR2 and VEGFR3 alters receptor tyrosine phosphorylation...
  12. ncbi Vascular endothelial growth factor induces chemotaxis and proliferation of microglial cells
    Frauke Forstreuter
    Department of Anatomy, University of Kiel, Olshausenstrasse 40, D 24098 Kiel, Germany
    J Neuroimmunol 132:93-8. 2002
    ..These results show that microglial cells are targets for VEGF which induces migration and proliferation of these immunocompetent cells in the brain...
  13. ncbi Signal transduction by VEGF receptors in regulation of angiogenesis and lymphangiogenesis
    Masabumi Shibuya
    University of Tokyo, Institute of Medical Science, 4 6 1 Shirokane dai, Tokyo 108 8639, Japan
    Exp Cell Res 312:549-60. 2006
    ..Mapping the signaling system of these important receptors may provide the knowledge necessary to suppress specific signaling pathways in major human diseases...
  14. ncbi Expression of vascular endothelial growth factor receptor 1 in bone marrow-derived mesenchymal cells is dependent on hypoxia-inducible factor 1
    Hiroaki Okuyama
    Vascular Biology Program, Institute for Cell Engineeringe, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Biol Chem 281:15554-63. 2006
    ..Thus, loss-of-function and gain-of-function approaches demonstrated that HIF-1 activity is necessary and sufficient for basal and hypoxia-induced VEGFR1 expression in bone marrow-derived MSC...
  15. pmc VEGF-dependent tumor angiogenesis requires inverse and reciprocal regulation of VEGFR1 and VEGFR2
    Z Zhang
    Angiogenesis Research Laboratory, Department of Restorative Sciences, University of Michigan, Ann Arbor, MI 48109 1078, USA
    Cell Death Differ 17:499-512. 2010
    ..Collectively, this work demonstrates that VEGF-induced angiogenesis requires inverse regulation of VEGFR1 and VEGFR2 in tumor-associated endothelial cells...
  16. ncbi Angiogenic and astroglial responses to vascular endothelial growth factor administration in adult rat brain
    J M Krum
    Department of Anatomy and Cell Biology, The George Washington University Medical Center, Washington, DC 20037, USA
    Neuroscience 110:589-604. 2002
    ..From these results we suggest that administered VEGF has heretofore unanticipated pleiotrophic effects in the adult CNS...
  17. ncbi Expression and function of vascular endothelial growth factor receptor-1 on human colorectal cancer cells
    Fan Fan
    Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030 4009, USA
    Oncogene 24:2647-53. 2005
    ....
  18. ncbi The vascular endothelial growth factor receptor (VEGFR-1) supports growth and survival of human breast carcinoma
    Yan Wu
    Department of Experimental Therapeutics, ImClone Systems Incorporated, New York, New York 10014, USA
    Int J Cancer 119:1519-29. 2006
    b>Vascular endothelial growth factor receptor 1 (VEGFR-1) is present on endothelial cells and subsets of human tumor cells, raising the hypothesis that angiogenic factors may promote tumor growth both by inducing angiogenesis and directly ..
  19. ncbi Role of PlGF in the intra- and intermolecular cross talk between the VEGF receptors Flt1 and Flk1
    Monica Autiero
    The Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, KULeuven, Leuven, B 3000, Belgium
    Nat Med 9:936-43. 2003
    ....
  20. ncbi Urinary angiogenic factors cluster hypertensive disorders and identify women with severe preeclampsia
    Catalin S Buhimschi
    Department of Obstetrics, Gynecology and Reproductive Science, Yale University, New Haven, CT 06520, USA
    Am J Obstet Gynecol 192:734-41. 2005
    ..We sought to identify whether similar alterations in urinary levels of these proteins cluster hypertensive disorders in pregnancy, and identify women with severe preeclampsia (sPE)...
  21. pmc Plasma vascular endothelial growth factor, soluble VEGF receptor FLT-1, and von Willebrand factor in glaucoma
    P L Lip
    Haemostasis, Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham, UK
    Br J Ophthalmol 86:1299-302. 2002
    ....
  22. pmc Vascular endothelial growth factor B (VEGF-B) binds to VEGF receptor-1 and regulates plasminogen activator activity in endothelial cells
    B Olofsson
    Ludwig Institute for Cancer Research, Stockholm Branch, Box 240, S 171 77 Stockholm, Sweden
    Proc Natl Acad Sci U S A 95:11709-14. 1998
    ....
  23. ncbi Vascular endothelial growth factor receptor-1 (VEGFR-1/Flt-1): a dual regulator for angiogenesis
    Masaubmi Shibuya
    Division of Genetics, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokane dai, Minato ku, Tokyo, 108 8639, Japan
    Angiogenesis 9:225-30; discussion 231. 2006
    ..VEGFR-1 including its soluble form is involved in a variety of human illnesses, making it an important target in the development of new strategies to suppress disease...
  24. pmc Modulation of angiogenesis by a tetrameric tripeptide that antagonizes vascular endothelial growth factor receptor 1
    Salvatore Ponticelli
    Angiogenesis Laboratory and Stem Cell Fate Laboratory, Institute of Genetics and Biophysics Adriano Buzzati Traverso, Consiglio Nazionale delle Ricerche CNR, 80131 Napoli, Italy
    J Biol Chem 283:34250-9. 2008
    ..This tetrameric tripeptide represents a new, promising compound for therapeutic approaches in pathologies where Flt-1 activation plays a crucial role...
  25. ncbi Semaphorin 3A-vascular endothelial growth factor-165 balance mediates migration and apoptosis of neural progenitor cells by the recruitment of shared receptor
    D Bagnard
    , Neurobiologie Experimentale et Physiopathologie, , 69372 Lyon Cedex 08, France
    J Neurosci 21:3332-41. 2001
    ..These results indicate that the balance between guidance molecules and angiogenic factors can modulate the migration, apoptosis (or survival), and proliferation of neural progenitor cells through shared receptors...
  26. ncbi The interaction of neuropilin-1 with vascular endothelial growth factor and its receptor flt-1
    G Fuh
    Department of Protein Engineering, Genentech Inc, South San Francisco, California 94080, USA
    J Biol Chem 275:26690-5. 2000
    ..Furthermore, Flt-1 may function as a negative regulator of angiogenesis by competing for NP-1...
  27. ncbi Sequential changes in antiangiogenic factors in early pregnancy and risk of developing preeclampsia
    Sarosh Rana
    Maternal Fetal Medicine Division, Women and Infants Hospital, Brown University, Providence, RI, USA
    Hypertension 50:137-42. 2007
    ..In conclusion, sequential changes in antiangiogenic factors during early pregnancy may be useful for predicting preterm preeclampsia...
  28. ncbi Vascular endothelial growth factor receptor-1 activation mediates epithelial to mesenchymal transition in human pancreatic carcinoma cells
    Anthony D Yang
    Department of Surgical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77230 1402, USA
    Cancer Res 66:46-51. 2006
    ..Given our previous finding of VEGFR-1-mediated tumor cell invasion and migration in pancreatic carcinoma cells, we hypothesize that VEGFR-1 plays a role in tumor progression in pancreatic cancer through the induction of EMT...
  29. ncbi Expression of vascular endothelial growth factor receptors 1, 2 and 3 in placentas from normal and complicated pregnancies
    S Helske
    Department of Obstetrics and Gynaecology, Helsinki University Central Hospital, PL 140, 00290 Helsinki, Finland
    Mol Hum Reprod 7:205-10. 2001
    ..These results suggest that low maternal serum PlGF and increased placental expression of its receptor VEGFR-1 are associated with pre-eclampsia and FGR...
  30. pmc A longitudinal study of angiogenic (placental growth factor) and anti-angiogenic (soluble endoglin and soluble vascular endothelial growth factor receptor-1) factors in normal pregnancy and patients destined to develop preeclampsia and deliver a small for
    Roberto Romero
    Perinatology Research Branch, National Institute of Child Health and Human Development, NIH DHHS, Bethesda, MD 20892, USA
    J Matern Fetal Neonatal Med 21:9-23. 2008
    ....
  31. ncbi Structure and dual function of vascular endothelial growth factor receptor-1 (Flt-1)
    M Shibuya
    Department of Genetics, Institute of Medical Science, University of Tokyo, 4-6-1 Shirokane-dai, Minato-ku, 108-8639, Tokyo, Japan
    Int J Biochem Cell Biol 33:409-20. 2001
    ..Furthermore, VEGFR-1 is involved in the VEGF-dependent migration and gene expression of monocyte/macrophages. Therefore, VEGFR-1 functions both in a positive and negative manner in different cellular systems and biological conditions...
  32. ncbi Cytotrophoblasts up-regulate soluble fms-like tyrosine kinase-1 expression under reduced oxygen: an implication for the placental vascular development and the pathophysiology of preeclampsia
    Takeshi Nagamatsu
    Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Endocrinology 145:4838-45. 2004
    ..The presented findings might provide a framework with which to understand the mechanism of uterine vascular remodeling and its perturbations as exemplified in preeclampsia...
  33. ncbi Uteroplacental ischemia results in proteinuric hypertension and elevated sFLT-1
    A Makris
    Vascular Immunology Laboratory, Heart Research Institute and University of Sydney, NSW, Australia
    Kidney Int 71:977-84. 2007
    ....
  34. ncbi Inhibition of tumor growth with antiangiogenic cancer vaccine using epitope peptides derived from human vascular endothelial growth factor receptor 1
    Hidenobu Ishizaki
    Department of Surgery and Bioengineering, Institute of Medical Science, The University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Clin Cancer Res 12:5841-9. 2006
    ..In this study, we examined the possibility of developing antiangiogenic cancer vaccine targeting vascular endothelial growth factor receptor 1 (VEGFR1) overexpressed on endothelial cells of newly formed vessels in the tumor.
  35. ncbi Antiangiogenic and antitumor activities of peptide inhibiting the vascular endothelial growth factor binding to neuropilin-1
    Anna Starzec
    Universite Paris 13, CNRS UMR 7033, Laboratoire de Pharmacologie Clinique et Experimentale, 93000 Bobigny, France
    Life Sci 79:2370-81. 2006
    ....
  36. ncbi Soluble vascular endothelial growth factor receptor-1 (sFlt-1) is increased throughout gestation in patients who have preeclampsia develop
    Gareth C McKeeman
    School of Medicine, Obstetrics and Gynecology, Institute of Clinical Science, Queen s University Belfast, Mulhouse Building, Grosvenort Road, Belfast BT12 6BW, Ireland
    Am J Obstet Gynecol 191:1240-6. 2004
    ....
  37. ncbi Soluble endoglin (sEng) joins the soluble fms-like tyrosine kinase (sFlt) receptor as a pre-eclampsia molecule
    Friedrich C Luft
    Franz Volhard Clinic, Medical Faculty of the Charite, HELIOS Klinikum Berlin, Max Delbruck Center for Molecular Medicine, Berlin Buch, Wiltberg Strasse 50, 13125 Berlin, Germany
    Nephrol Dial Transplant 21:3052-4. 2006
  38. pmc Increased sFlt-1 to PlGF ratio in women who subsequently develop preeclampsia
    Shin Young Kim
    Laboratory of Medical Genetics, Cheil General Hospital and Women s Healthcare Center, Kwandong University School of Medicine, Seoul, Korea
    J Korean Med Sci 22:873-7. 2007
    ..Accordingly, the sFlt-1/PlGF ratio may provide early prediction of subsequent development of preeclampsia...
  39. ncbi GM-CSF induces expression of soluble VEGF receptor-1 from human monocytes and inhibits angiogenesis in mice
    Tim D Eubank
    The Dorothy M Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH 43210, USA
    Immunity 21:831-42. 2004
    ..Thus, GM-CSF and monocytes play a vital role in angiogenesis through the regulation of VEGF and sVEGFR-1...
  40. ncbi Up-regulation of proproliferative genes and the ligand/receptor pair placental growth factor and vascular endothelial growth factor receptor 1 in hepatitis C cirrhosis
    Xiao X Huang
    A W Morrow Gastroenterology and Liver Centre at Royal Prince Alfred Hospital, NSW, Australia
    Liver Int 27:960-8. 2007
    ..Cirrhosis can lead to hepatocellular carcinoma (HCC). Non-diseased liver and hepatitis C virus (HCV)-associated cirrhosis with or without HCC were compared...
  41. ncbi The splice variants of vascular endothelial growth factor (VEGF) and their receptors
    C J Robinson
    The Cancer Research Campaign Department of Drug Development and the CRC and University of Manchester Department of Medical Oncology, Paterson Institute for Cancer Research, Christie Hospital, Manchester, M20 4BX, UK
    J Cell Sci 114:853-65. 2001
    ..HSPGs have a wide variety of functions, such as the ability to partially restore lost function to damaged VEGF(165) and thereby prolonging its biological activity...
  42. ncbi Upregulation of urotensin II receptor in preeclampsia causes in vitro placental release of soluble vascular endothelial growth factor receptor 1 in hypoxia
    Phillip S Gould
    Clinical Sciences Research Institute, Warwick Medical School, University of Warwick, Coventry, United Kingdom
    Hypertension 56:172-8. 2010
    ..The increase in levels of soluble vascular endothelial growth factor receptor 1, an antiangiogenic agent known to inhibit placental vascularization, is an important cellular ..
  43. pmc A recently evolved novel trophoblast-enriched secreted form of fms-like tyrosine kinase-1 variant is up-regulated in hypoxia and preeclampsia
    Christie P Thomas
    Department of Internal Medicine, of Iowa College of Medicine, Iowa City, Iowa 52242, USA
    J Clin Endocrinol Metab 94:2524-30. 2009
    ..Recent published studies indicate a possible role for sFlt1 in the development of preeclampsia...
  44. ncbi Pigment epithelium-derived factor inhibits angiogenesis via regulated intracellular proteolysis of vascular endothelial growth factor receptor 1
    Jun Cai
    School of Optometry and Vision Sciences, Cardiff University, UK
    J Biol Chem 281:3604-13. 2006
    ..This confirms the importance of PEDF and VEGFR-1 in the negative regulation of angiogenesis...
  45. ncbi Plasma angiopoietin-1, angiopoietin-2 and Tie-2 in breast and prostate cancer: a comparison with VEGF and Flt-1
    G J Caine
    Haemostasis, Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham, UK
    Eur J Clin Invest 33:883-90. 2003
    ..These growth factors include angiopoietin-1 (Ang-1), angiopoietin-2 (Ang-2) and vascular endothelial growth factor (VEGF), which act through receptors Flt-1 and Tie-2...
  46. ncbi Two independent mechanisms essential for tumor angiogenesis: inhibition of human melanoma xenograft growth by interfering with either the vascular endothelial growth factor receptor pathway or the Tie-2 pathway
    G Siemeister
    Institute of Molecular Medicine, Tumor Biology Center, Frieburg, Germany
    Cancer Res 59:3185-91. 1999
    ..These findings suggest that the VEGF receptor pathway and the Tie-2 pathway have to be considered as two independent mediators essential for the process of in vivo angiogenesis...
  47. ncbi Overexpression of soluble vascular endothelial growth factor receptor 1 in colorectal cancer: Association with progression and prognosis
    Tatsuro Yamaguchi
    Department of Surgery, Tokyo Metropolitan Komagome Hospital, Tokyo Metropolitan Cancer and Infectious Disease Center, Tokyo 113 8677, Japan
    Cancer Sci 98:405-10. 2007
    ..Furthermore, sVEGFR1 levels showed a significant prognostic value. Further studies concerning the biologic and therapeutic significance of sVEGFR1 in colorectal cancer are warranted...
  48. ncbi MMP9 induction by vascular endothelial growth factor receptor-1 is involved in lung-specific metastasis
    Sachie Hiratsuka
    Department of Genetics, Institute of Medical Science, University of Tokyo, Minato ku, Tokyo 108 8639, Japan
    Cancer Cell 2:289-300. 2002
    ..Thus, a block of MMP9 induction via VEGFR-1 inhibition could be useful for the prevention of tumor metastasis in lung...
  49. ncbi VEGF-dependent plasticity of fenestrated capillaries in the normal adult microvasculature
    Tomomi Kamba
    Cardiovascular Research Institute, and Dept of Anatomy, Univ of California, 513 Parnassus Ave, San Francisco, CA 94143 0452, USA
    Am J Physiol Heart Circ Physiol 290:H560-76. 2006
    ..Our findings of VEGF dependency of normal fenestrated capillaries and rapid regrowth after regression demonstrate the plasticity of the adult microvasculature...
  50. ncbi Anti-vascular endothelial growth factor gene therapy attenuates lung injury and fibrosis in mice
    Naoki Hamada
    Research Institute for Diseases of the Chest, Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    J Immunol 175:1224-31. 2005
    ..Furthermore, this method may be beneficial for treating lung injury and fibrosis from the viewpoint of clinical application, since it does not require the use of a viral vector or neutralizing Ab...
  51. ncbi The molecular basis of VEGFR-1 signal transduction pathways in primary human monocytes
    Vadim Tchaikovski
    Department of Cardiology, University Hospital of Maastricht, Cardiovascular Research Institute of Maastricht, P Debyelaan 25, P O Box 5800, 6202 AZ Maastricht, The Netherlands
    Arterioscler Thromb Vasc Biol 28:322-8. 2008
    ..Little is known about intracellular signaling pathways mediating the biological functions triggered by VEGFR-1 in primary monocytes...
  52. ncbi Elevated placental soluble vascular endothelial growth factor receptor-1 inhibits angiogenesis in preeclampsia
    Shakil Ahmad
    Department of Reproductive and Vascular Biology, The Medical School, University of Birmingham, Edgbaston, Birmingham, West Midlands B15 2TG, UK
    Circ Res 95:884-91. 2004
    ..Our finding demonstrates the dysregulation of the VEGF/PlGF axis in preeclampsia and offers an entirely new therapeutic approach to its treatment...
  53. ncbi The VEGF receptor flt-1 (VEGFR-1) is a positive modulator of vascular sprout formation and branching morphogenesis
    Joseph B Kearney
    Program in Genetics and Molecular Biology, Department of Biology, CB 3280, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Blood 103:4527-35. 2004
    ..Thus precise levels of bioactive VEGF-A and perhaps spatial localization of the VEGF signal are likely modulated by flt-1 to ensure proper sprout formation during blood vessel formation...
  54. ncbi The role of vascular endothelial growth factor in angiogenesis
    N Ferrara
    Department of Molecular Oncology, Genentech, Inc, South San Francisco, Calif 94080, USA
    Acta Haematol 106:148-56. 2001
    ..Substantial evidence also implicates VEGF in tumors and intraocular neovascular syndromes. Currently, several clinical trials are ongoing to test the hypothesis that inhibition of VEGF activity may be beneficial for these conditions...
  55. ncbi Role of placenta growth factor and its receptor flt-1 in rheumatoid inflammation: a link between angiogenesis and inflammation
    Seung Ah Yoo
    Catholic University of Korea, Seoul, Korea
    Arthritis Rheum 60:345-54. 2009
    ..To investigate the direct effects of placenta growth factor (PlGF) and its specific receptor, flt-1, which are known to mediate angiogenesis, on the inflammatory process of rheumatoid arthritis (RA)...
  56. ncbi Transduction of soluble Flt-1 gene to peritoneal mesothelial cells can effectively suppress peritoneal metastasis of gastric cancer
    Akihiro Sako
    Department of Surgical Oncology, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    Cancer Res 64:3624-8. 2004
    ..p. injection of Ad-sFlt-1. Anti-angiogenic gene therapy targeted to PMCs could be a novel and practical strategy against peritoneal dissemination of gastric cancer, because it does not require tumor-specific gene transfer...
  57. pmc VEGF-Trap: a VEGF blocker with potent antitumor effects
    Jocelyn Holash
    Regeneron Pharmaceuticals, Incorporated, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA
    Proc Natl Acad Sci U S A 99:11393-8. 2002
    ..VEGF-Trap-mediated blockade may be superior to that achieved by other agents, such as monoclonal antibodies targeted against the VEGF receptor...
  58. ncbi Mapping the theories of preeclampsia and the role of angiogenic factors: a systematic review
    Mariana Widmer
    Nuffield Department of Obstetrics and Gynecology, University of Oxford, John Radcliffe Hospital, Oxford, UK
    Obstet Gynecol 109:168-80. 2007
    ..To evaluate claims that elevated soluble fms-like tyrosine kinase-1 receptor (sFlt-1) and decreased placental growth factor predict preeclampsia...
  59. pmc The vascular endothelial growth factor (VEGF) receptor Flt-1 (VEGFR-1) modulates Flk-1 (VEGFR-2) signaling during blood vessel formation
    David M Roberts
    Program in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill 27599, USA
    Am J Pathol 164:1531-5. 2004
    ....
  60. ncbi Expression of vascular endothelial growth factor receptors 1, 2, and 3 in quiescent endothelia
    Antonella N Witmer
    Ocular Angiogenesis Group, Department of Ophthalmology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Histochem Cytochem 50:767-77. 2002
    ..One of these functions may be involvement of VEGF in paracrine relations between epithelia and adjacent capillaries...
  61. ncbi Extra-placental expression of vascular endothelial growth factor receptor-1, (Flt-1) and soluble Flt-1 (sFlt-1), by peripheral blood mononuclear cells (PBMCs) in normotensive and preeclamptic pregnant women
    A Rajakumar
    Department of Obstetrics and Gynecology and Reproductive Sciences, Magee Womens Research Institute, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Placenta 26:563-73. 2005
    ..The present study indicates that Flt-1 dysregulation in PBMCs of pregnant women resulting in over-expression of sFlt-1 could be an additional (extra-placental) source of sFlt-1 that contributes to the pathogenesis of preeclampsia...
  62. ncbi Homeostatic modulation of cell surface KDR and Flt1 expression and expression of the vascular endothelial cell growth factor (VEGF) receptor mRNAs by VEGF
    D Wang
    Surgical Oncology Laboratory, Department of Surgery, University of California at San Francisco, San Francisco, California 94143 0790, USA
    J Biol Chem 275:15905-11. 2000
    ....
  63. ncbi Vascular and haematopoietic stem cells: novel targets for anti-angiogenesis therapy?
    Shahin Rafii
    Division of Hematology Oncology, Cornell University Medical College, 1300 York Avenue, Room D601, New York, New York 10021, USA
    Nat Rev Cancer 2:826-35. 2002
  64. ncbi The interaction of Neuropilin-1 and Neuropilin-2 with tyrosine-kinase receptors for VEGF
    Gera Neufeld
    Department of Biology, Technion, Israel Institute of Technology, Haifa, 32000, Israel
    Adv Exp Med Biol 515:81-90. 2002
    ..In contrast, it was recently reported by two laboratories that Neuropilins can form complexes with the second tyrosine-kinase receptor of VEGF, VEGFR1. However, the biological function of these complexes is still unclear...
  65. ncbi Novel splice variants of sFlt1 are upregulated in preeclampsia
    M Heydarian
    Department of Biochemistry and Molecular Biology, George Washington University, Washington, DC 20037, USA
    Placenta 30:250-5. 2009
    ..These findings provide evidence that human placenta expresses a family of sFlt1 splice variants, at least three of which are expressed as proteins, and which appear to be globally upregulated in preeclampsia...
  66. ncbi Differential expression of VEGF isoforms in mouse during development and in the adult
    Y S Ng
    Department of Ophthalmology, Harvard Medical School and Schepens Eye Research Institute, Boston, MA 02114, USA
    Dev Dyn 220:112-21. 2001
    ..Our results support the concept that different VEGF isoforms have distinct functions in vascular development...
  67. ncbi Vascular endothelial growth factor receptor Flt-1 negatively regulates developmental blood vessel formation by modulating endothelial cell division
    Joseph B Kearney
    Program in Genetics and Molecular Biology, Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Blood 99:2397-407. 2002
    ..Taken together, these data show that flt-1 normally modulates vascular growth by controlling the rate of endothelial cell division both in vitro and in vivo...
  68. ncbi Regulation of placental vascular endothelial growth factor (VEGF) and placenta growth factor (PIGF) and soluble Flt-1 by oxygen--a review
    A Ahmed
    Department of Reproductive and Vascular Biology, University of Birmingham, Birmingham Women s Hospital, Edgbaston, UK
    Placenta 21:S16-24. 2000
    ..Taken together these changes provide a molecular explanation for the observed poor angiogenesis in the pathogenesis of IUGR...
  69. ncbi Regulation of endothelial proliferation by the renin-angiotensin system in human umbilical vein endothelial cells
    D Herr
    Department of Obstetrics and Gynaecology, Ulm University Medical Centre, Universitäts Frauenklinik Ulm, Prittwitzstrasse 43, 89075 Ulm, Germany
    Reproduction 136:125-30. 2008
    ..This is the first report of the RAS on the regulation of angiogenesis-associated genes in physiology...
  70. ncbi Flt-1, vascular endothelial growth factor receptor 1, is a novel cell surface marker for the lineage of monocyte-macrophages in humans
    A Sawano
    Department of Genetics and Department of Clinical Oncology, Institute of Medical Science, University of Tokyo, Japan
    Blood 97:785-91. 2001
    Flt-1, also known as vascular endothelial growth factor receptor 1 (VEGFR-1), is a high-affinity tyrosine kinase receptor for VEGF and is expressed almost exclusively on vascular endothelial cells...
  71. ncbi Angiogenesis in systemic sclerosis: impaired expression of vascular endothelial growth factor receptor 1 in endothelial progenitor-derived cells under hypoxic conditions
    J Avouac
    Université Paris Descartes and Hôpital Cochin, Assistance Publique Hopitaux de Paris, Paris, and INSERM U781, Hopital Necker, Paris, France
    Arthritis Rheum 58:3550-61. 2008
    ..To assess angiogenesis and explore the expression and regulation of vascular endothelial growth factor (VEGF), VEGF receptor 1 (VEGFR-1), and VEGFR-2, the leading mediators of angiogenesis, in SSc patients and controls...
  72. pmc Hypoxia increases placenta growth factor expression in human myocardium and cultured neonatal rat cardiomyocytes
    Ronald J Torry
    College of Pharmacy and Health Sciences, Drake University, Des Moines, Iowa 50311 4505, USA
    J Heart Lung Transplant 28:183-90. 2009
    ..However, little is known regarding the regulation of PlGF expression in heart tissue...
  73. ncbi Comparative structure-function analysis of VEGFR-1 and VEGFR-2: What have we learned from chimeric systems?
    Rosana D Meyer
    Departments of Ophthalmology and Biochemistry, Boston University, School of Medicine, Boston, Massachusetts 02118, USA
    Ann N Y Acad Sci 995:200-7. 2003
    ..Second, activation of VEGFR-2 is associated with many endothelial cell functions, including cell proliferation, migration, and differentiation. Third, activation of PI3 kinase by VEGFR-2 regulates endothelial cell proliferation...
  74. ncbi Intronic polyadenylation signal sequences and alternate splicing generate human soluble Flt1 variants and regulate the abundance of soluble Flt1 in the placenta
    Christie P Thomas
    Department of Internal Medicine and Graduate Program in Molecular and Cellular Biology, E300 GH, University of Iowa Carver College of Medicine, 200 Hawkins Dr, Iowa City, IA 52242 1081 USA
    FASEB J 21:3885-95. 2007
    ....
  75. pmc Membrane fixation of vascular endothelial growth factor receptor 1 ligand-binding domain is important for vasculogenesis and angiogenesis in mice
    Sachie Hiratsuka
    Division of Genetics, Institute of Medical Science, University of Tokyo, Tokyo 108 8639, Japan
    Mol Cell Biol 25:346-54. 2005
    ..These results strongly suggest that the membrane-fixed ligand-binding region of VEGFR1 traps VEGF for the appropriate regulation of VEGF signaling in vascular endothelial cells during early embryogenesis...
  76. ncbi Plasma levels of vascular endothelial growth factor and its soluble receptor (SFlt-1) in essential hypertension
    F M Belgore
    University Department of Medicine, City Hospital, Birmingham, United Kingdom
    Am J Cardiol 87:805-7, A9. 2001
    ..This raises the possibility that abnormal angiogenesis may contribute to the pathogenesis of complications related to hypertension and merits exploration in larger studies...
  77. ncbi A novel human-specific soluble vascular endothelial growth factor receptor 1: cell-type-specific splicing and implications to vascular endothelial growth factor homeostasis and preeclampsia
    Shay Sela
    Department of Molecular Biology, The Hebrew University Hadassah Medical School, Jerusalem 91120, Israel
    Circ Res 102:1566-74. 2008
    ..Furthermore, the study uncovered the identity of a VEGF-blocking protein implicated in preeclampsia...
  78. pmc Placental growth factor reconstitutes hematopoiesis by recruiting VEGFR1(+) stem cells from bone-marrow microenvironment
    Koichi Hattori
    Department of Medicine, Cornell University Medical College, New York, New York, USA
    Nat Med 8:841-9. 2002
    ..Thus, PlGF promotes recruitment of VEGFR1(+) HSCs from a quiescent to a proliferative BM microenvironment, favoring differentiation, mobilization and reconstitution of hematopoiesis...
  79. ncbi VEGF and PlGF promote adult vasculogenesis by enhancing EPC recruitment and vessel formation at the site of tumor neovascularization
    Bin Li
    Department of Pathology, Vanderbilt University School of Medicine, 1161 21st Ave South, C2217 MCN, Nashville, Tennessee 37232, USA
    FASEB J 20:1495-7. 2006
    ..Our data suggest local VEGF and/or PlGF expression promote vasculogenesis; VEGF plays a role in EPC recruitment and subsequent formation of functional vessels...
  80. ncbi The combination of epigallocatechin gallate and curcumin suppresses ER alpha-breast cancer cell growth in vitro and in vivo
    Tiffany J Somers-Edgar
    Department of Pharmacology and Toxicology, University of Otago, Dunedin, New Zealand
    Int J Cancer 122:1966-71. 2008
    ..Therefore, these results demonstrate that the combination of EGCG and curcumin is efficacious in both in vitro and in vivo models of ER alpha-breast cancer and that regulation of VEGFR-1 may play a key role in this effect...
  81. pmc The VEGF receptor Flt-1 spatially modulates Flk-1 signaling and blood vessel branching
    Nicholas C Kappas
    Department of Biology, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    J Cell Biol 181:847-58. 2008
    ....
  82. ncbi [Predictive value of soluble vascular endothelial growth factor receptor 1 for preeclampsia in second-trimester]
    Qian Chen
    Department of Obstetrics and Gynecology, Xiehe Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
    Zhonghua Fu Chan Ke Za Zhi 42:161-4. 2007
    To evaluate the predictive value of plasma levels of soluble vascular endothelial growth factor receptor 1 (VEGFR-1, also known as sFlt-1) in second-trimester for preeclampsia.
  83. ncbi Localization of vascular endothelial growth factor (VEGF) and its receptors VEGFR-1 and VEGFR-2 in bovine placentomes from implantation until term
    C D Pfarrer
    Department of Veterinary Anatomy, Histology and Embryology, Justus Liebig University Giessen, D 35392 Giessen, Germany
    Placenta 27:889-98. 2006
    ....
  84. ncbi Angiogenesis-independent endothelial protection of liver: role of VEGFR-1
    Jennifer LeCouter
    Departments of Molecular Oncology, Protein Engineering, and Pathology, Genentech Inc, 1 DNA Way, South San Francisco, CA 94080, USA
    Science 299:890-3. 2003
    ..Thus, VEGFR-1 agonists may have therapeutic potential for preservation of organ function in certain liver disorders...
  85. ncbi Expression of vascular endothelial growth factor and its receptors flt and KDR in ovarian carcinoma
    C A Boocock
    Department of Obstetrics and Gynaecology, University of Cambridge, Rosie Maternity Hospital, England
    J Natl Cancer Inst 87:506-16. 1995
    ..The known human receptors for VEGF, flt and KDR, are both cell surface tyrosine kinases and are expressed predominantly on endothelial cells. Acting through these receptors, VEGF may stimulate angiogenesis and promote tumor progression...
  86. ncbi An angiogenic switch in breast cancer involves estrogen and soluble vascular endothelial growth factor receptor 1
    Michael Elkin
    Cell Biology Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
    J Natl Cancer Inst 96:875-8. 2004
    ..Our data suggest that inhibition of soluble VEGFR-1 expression represents a novel mechanism--an estrogen-driven angiogenic switch--possibly responsible for breast carcinoma progression...
  87. ncbi Clinical impact of phosphorylated signal transducer and activator of transcription 3, epidermal growth factor receptor, p53, and vascular endothelial growth factor receptor 1 expression in resected adenocarcinoma of lung by using tissue microarray
    Hyeong Su Kim
    Division of Hematology and Oncology, Department of Internal Medicine, Hallym University Medical Center, Hallym University College of Medicine, Seoul, Korea
    Cancer 116:676-85. 2010
    ..The clinical significance of phosphorylated STAT3 (pSTAT3), EGFR, p53, and vascular endothelial growth factor receptor 1 (VEGFR-1) expression in patients with completely resected lung adenocarcinoma was evaluated to ..
  88. ncbi Significance of vascular endothelial growth factor (VEGF)/soluble VEGF receptor-1 relationship in breast cancer
    Masakazu Toi
    Breast Unit, Tokyo Metropolitan Komagome Hospital, Bunkyo ku, Tokyo, Japan
    Int J Cancer 98:14-8. 2002
    ..In conclusion, sVEGFR1, an intrinsic inhibitor of VEGF, frequently co-expressed with VEGF in primary breast cancer tissues. The intratumoral balance between sVEGFR1 and VEGF levels might be crucial for the progression of breast cancer...
  89. ncbi Serum vascular endothelial growth factor/soluble vascular endothelial growth factor receptor 1 ratio is an independent prognostic marker in pancreatic cancer
    Yu Ting Chang
    Department of Internal Medicine, National Taiwan University Hospital and College of Medicine, National Taiwan University, Taipei, Taiwan
    Pancreas 37:145-50. 2008
    ..factors, including vascular endothelial growth factor (VEGF), placental growth factor (PlGF), and soluble vascular endothelial growth factor receptor 1 (sVEGFR-1), in predicting clinical outcome in patients with pancreatic cancer.
  90. pmc Corneal avascularity is due to soluble VEGF receptor-1
    Balamurali K Ambati
    Department of Ophthalmology, Medical College of Georgia and Augusta Veterans Affairs Medical Center, Augusta, Georgia 30907, USA
    Nature 443:993-7. 2006
    ....
  91. pmc Vascular endothelial growth factor ligands and receptors that regulate human cytotrophoblast survival are dysregulated in severe preeclampsia and hemolysis, elevated liver enzymes, and low platelets syndrome
    Yan Zhou
    Department of Stomatology, University of California San Francisco, San Francisco, California 94143 0512, USA
    Am J Pathol 160:1405-23. 2002
    ..Together, the results of this study showed that VEGF family members regulate cytotrophoblast survival and that expression of a subset of family members is dysregulated in severe forms of preeclampsia...
  92. ncbi Activation of proteinase-activated receptor 2 stimulates soluble vascular endothelial growth factor receptor 1 release via epidermal growth factor receptor transactivation in endothelial cells
    Bahjat Al-Ani
    Department of Reproductive and Vascular Biology, Institute for Biomedical Research, Medical School, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    Hypertension 55:689-97. 2010
    ....
  93. ncbi Placenta growth factor. Potentiation of vascular endothelial growth factor bioactivity, in vitro and in vivo, and high affinity binding to Flt-1 but not to Flk-1/KDR
    J E Park
    Genentech, Inc, South San Francisco, California 94080
    J Biol Chem 269:25646-54. 1994
    ..Purified PIGF isoforms had little or no direct mitogenic or permeability-enhancing activity. However, they were able to significantly potentiate the action of low concentrations of VEGF in vitro and, more strikingly, in vivo...
  94. pmc Transforming growth factor beta1 induction of vascular endothelial growth factor receptor 1: mechanism of pericyte-induced vascular survival in vivo
    Shu Ching Shih
    Department of Ophthalmology, Harvard Medical School and Children s Hospital, 300 Longwood Avenue, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 100:15859-64. 2003
    ..These results implicate induction and activation of VEGFR-1 as critical targets to prevent vessel loss...
  95. ncbi Competitive ELISA-based screening of plant derivatives for the inhibition of VEGF family members interaction with vascular endothelial growth factor receptor 1
    Salvatore Ponticelli
    Angiogenesis Lab and Stem Cell Fate Lab, Istituto di Genetica e Biofisica Adriano Buzzati Traverso, CNR, Napoli, Italy
    Planta Med 74:401-6. 2008
    ..This activity seems be due to the presence of a combination of compounds acting synergistically...
  96. ncbi Direct evidence for endothelial vascular endothelial growth factor receptor-1 function in nitric oxide-mediated angiogenesis
    Shakil Ahmad
    Department of Reproductive and Vascular Biology, Institute for Biomedical Research, The Medical School, University of Birmingham, Birmingham B15 2TT, UK
    Circ Res 99:715-22. 2006
    ..These studies provide new sites of modulation in VEGF-mediated vascular morphogenesis and highlight new therapeutic targets for management of vascular diseases...
  97. ncbi Role of vascular endothelial growth factor receptor 1 in basal adhesion formation and in carbon dioxide pneumoperitoneum-enhanced adhesion formation after laparoscopic surgery in mice
    Carlos Roger Molinas
    Department of Obstetrics and Gynecology, University Hospital Gasthuisberg, Katholieke Universiteit Leuven, Leuven, Belgium
    Fertil Steril 82:1149-53. 2004
    ..To evaluate the role of vascular endothelial growth factor receptor-1 (VEGFR-1) in adhesion formation after laparoscopic surgery...
  98. pmc A single-nucleotide polymorphism in a half-binding site creates p53 and estrogen receptor control of vascular endothelial growth factor receptor 1
    Daniel Menendez
    Laboratory of Molecular Genetics MD3 01, National Institute of Environmental Health Sciences, 111 Alexander Drive, Research Triangle Park, NC 27709, USA
    Mol Cell Biol 27:2590-600. 2007
    ..Recently, we reported a C-->T single-nucleotide polymorphism (SNP) in the vascular endothelial growth factor receptor 1 (VEGFR-1/Flt1) promoter that merges human VEGF and p53 pathways...
  99. ncbi Vascular endothelial growth factors synthesized by human lung mast cells exert angiogenic effects
    Aikaterini Detoraki
    Department of Clinical Immunology and Allergy, Center for Basic and Clinical Immunology Research CISI, University of Naples Federico II, Naples, Italy
    J Allergy Clin Immunol 123:1142-9, 1149.e1-5. 2009
    ..Angiogenesis and lymphangiogenesis are critical for several allergic, inflammatory, and neoplastic disorders. Mast cells infiltrate the sites of inflammation and tumors...
  100. ncbi Circulating concentrations of sFlt1 (soluble fms-like tyrosine kinase 1) in fetal and maternal serum during pre-eclampsia
    Anne Cathrine Staff
    Department of Obstetrics and Gynecology, Ulleval University Hospital, Kirkeveien 166, N 0450, Oslo, Norway
    Eur J Obstet Gynecol Reprod Biol 122:33-9. 2005
    ..We hypothesized that umbilical vein serum soluble fms-like tyrosine kinase 1 (sFlt1) concentration was augmented in pre-eclampsia. We also explored a possible association between fetal and maternal concentrations of sFlt1...
  101. ncbi Coordinate expression of vascular endothelial growth factor receptor-1 (flt-1) and its ligand suggests a paracrine regulation of murine vascular development
    G Breier
    Max Planck Institut fur Physiologische und Klinische Forschung, Bad Nauheim, Germany
    Dev Dyn 204:228-39. 1995
    ..The data are consistent with the hypothesis that VEGF and its receptors have an important function both in the differentiation of the endothelial lineage and in the neovascularization of developing organs, and act in a paracrine fashion...

Research Grants65

  1. The Role of Vascular MR-Regulated Genes in Vascular Function and Disease
    Iris Z Jaffe; Fiscal Year: 2013
    ..abstract_text> ..
  2. Complement Activation in Pregnancy and Hypertension
    Jean F Regal; Fiscal Year: 2013
    ....
  3. Engineering the Brain Immune System for Tumor Therapy
    Maria G Castro; Fiscal Year: 2013
    ....
  4. Vascular Mechanisms in Pregnancy-Induced Hypertension
    Raouf A Khalil; Fiscal Year: 2013
    ....
  5. Angiogenic factors, abnormal placentation and adverse pregnancy outcomes
    Sarosh Rana; Fiscal Year: 2013
    ..The combined expertise of mentors and collaborators provide a unique opportunity for the applicant to achieve the goals of this project and to start a career as an independent investigator. ..
  6. Gutless Adenovirus Mediated Gene Therapy for Glioma
    Maria G Castro; Fiscal Year: 2011
    ..Having met all previous milestones, we propose to file for FDA approval towards the end of this U01 proposal. ..
  7. The p110 alpha and delta isoforms of PI3 kinase in hematopoiesis and leukemia
    Kira Gritsman; Fiscal Year: 2013
    ..This proposal will use mouse knockout models to examine whether the p110 and p110 subunits of PI3 kinase are important for normal HSC function and are feasible targets for leukemia therapy. ..
  8. Modeling preeclampsia in mice with inducible placenta-specific gene expression
    Nihar R Nayak; Fiscal Year: 2012
    ....
  9. Stat5b in Lymphomagenesis: Mechanistic and Therapeutic Implications
    John A Kelly; Fiscal Year: 2012
    ..These experiments have the potential to advance the therapeutic approaches in lymphoma and other malignancies. ..
  10. Plerixafor/G-CSF with Sorafenib for Acute Myelogenous Leukemia with FLT3-ITD Muta
    MICHAEL W ANDREEFF; Fiscal Year: 2012
    ..CXCR4 inhibitor AMD3100, G-CSF and Sorafenib will be administered sequentially to patients with advanced myeloid leukemia. ..
  11. Role of Shp2 in FLT3-ITD-Induced Leukemogenesis
    Reuben Kapur; Fiscal Year: 2013
    ..Results from these studies are expected to identify new therapeutic targets for treating AML. ..
  12. Modulation of liver fibrosis resolution by dendritic cells
    Costica Aloman; Fiscal Year: 2013
    ..These studies should uncover new pathways to accelerate fibrosis regression, leading to innovative treatments for patients with advanced fibrosis. ..
  13. Endothelial Dysfunction in the Pathogenesis of Sickle Cell Nephropathy
    Kenneth I Ataga; Fiscal Year: 2013
    ..abstract_text> ..
  14. Hypertensive Mechanisms in Preeclampsia
    ERIC MATTHEW GEORGE; Fiscal Year: 2013
    ..In order to test these hypotheses, a number of in vitro and in vivo approaches will be used. ..
  15. Improved Therapies for AML in the Elderly
    SARAH C NABINGER; Fiscal Year: 2011
    ..Our laboratory has outlined studies to examine what induces the blood cells to become malignant with the long term goal of developing less toxic and curative drugs for this disease. ..
  16. Dissociating hypoxia from pathology in preeclampsia and*
    Stacy Zamudio; Fiscal Year: 2007
    ..The hypothesis tested is that the soluble vascular endothelial growth factor receptor 1 (sFlt-1), an anti-angiogenic soluble receptor produced in excess where placental hypoxia is ..
  17. Cytokines for Immune Protection from Acute Irradiation
    George Georges; Fiscal Year: 2005
    ..The secondary endpoint is immune reconstitution. Upon study completion, we will have identified the optimal cytokine treatment and the highest dose of TBI that can be reliably survived without HSC support. ..
  18. Pulmonary Vascular Tree Development, Growth & Remodling
    Robb Glenny; Fiscal Year: 2005
    ..The findings will fill important gaps in our knowledge of pulmonary vascular development and triggers of remodeling. ..
  19. VASCULAR ENDOTHELIAL GROWTH FACTOR IN LUNG ISCHEMIA
    Patrice Becker; Fiscal Year: 2002
    ....
  20. Role of Host Dendritic Cells in Heart Transplant Vasculopathy
    Zhiliang Wang; Fiscal Year: 2007
    ..We believe the data from the proposal will lead to better understanding of the pathogenesis and therapy of graft chronic rejection. [unreadable] [unreadable]..
  21. Glioma regression using gutless adenoviral vectors
    GWENDALYN KING; Fiscal Year: 2007
    ..Tumor regression observed in animals treated with TK/Flt3L is hypothesized to occur by activation of innate and adaptive branches of the immune system. ..
  22. Anti-angiogenic signaling molecules in retinal cells
    Nader Rahimi; Fiscal Year: 2004
    ..our long-term goal is to begin to apply the information obtained from this project to the design of strategies to regulate angiogenesis in clinical settings. ..
  23. VEGFR-1 and VEGFR-2 in angiogenesis
    Nader Rahimi; Fiscal Year: 2006
    ..Once we determine the mechanism by which VEGF receptors are engaged it will be possible to attenuate the angiogenic signal transduction relay by developing targeted therapeutic interventions aimed at angiogenesis suppression ..
  24. Role of Protein Ubiquitination in Angiogenesis
    Nader Rahimi; Fiscal Year: 2010
    ..Identification of molecules that inhibit the angiogenic signaling of VEGFR-2 will provide new avenues for development of better and more effective agents to combat angiogenesis-associated diseases. ..
  25. Targeting Placental Pathophysiology in IUGR and Preeclampsia
    Seth Guller; Fiscal Year: 2010
    ..However, we feel that despite modifications to the original research plan, our application provides an exciting and novel framework for elucidating pathways of placental damage in IUGR and PE. ..
  26. REGULATION AND FUNCTION OF THE ALPHA SUBUNIT OF ENAC
    Christie Thomas; Fiscal Year: 2003
    ..The long-term objectives are to understand the regulation and function of ENaC in transepithelial Na+ transport. ..
  27. Sgk1 in Na+ transport in fetal lung epithelia
    Christie Thomas; Fiscal Year: 2007
    ..abstract_text> ..
  28. Mechanisms of myometrial healing and regeneration
    Catalin Buhimschi; Fiscal Year: 2006
    ....
  29. Single Agents with Designed Combination Chemotherapy Potential
    Aleem Gangjee; Fiscal Year: 2010
    ..abstract_text> ..
  30. Enhancement of Dendritic Cells After Burn Injury
    Tracy Toliver Kinsky; Fiscal Year: 2009
    ..These studies will determine rf enhancement of dendritic cells after severe bums can increase resistance to bum wound infection, and will determine the contribution of dendritic cells to specific immune functions. ..
  31. Alpha Folate Receptor Mediated GARFTase Inhibitors as Selective Antitumor Agents
    Aleem Gangjee; Fiscal Year: 2010
    ....
  32. Novel, P. jirovecii Specific Antipneumocystis Agents
    Aleem Gangjee; Fiscal Year: 2009
    ..These agents could be used alone or in combination to treat PCP thus providing novel agents against a new target. ..
  33. Skin Manifestations of Tuberous Sclerosis
    Jack Arbiser; Fiscal Year: 2009
    ..Specific Aim 3. To determine whether dysregulation of p16ink4a and PTCH (patched) acts as a modifier of theTS phenotype in transgenic mice expressing dominant negative tuberin. ..
  34. STRUCTURE BASED ANALOGS AS ANTIOPPORTUNISTIC AGENTS
    Aleem Gangjee; Fiscal Year: 2001
    ..The analogues synthesized will also be submitted for screening against tuberculosis (NIAID) parasitic diseases (WHO) and tumor cells in culture (NCI). ..
  35. Angiogenesis-related gene products in preeclampsia
    S Karumanchi; Fiscal Year: 2008
    ..These focused studies will form the beginnings of a framework for understanding the role of angiogenesis-related gene products in pathogenesis of PE and for exploring novel avenues for the treatment of PE. ..
  36. Role of VEGF in Glomerular Endothelial Health & Diseases
    S Karumanchi; Fiscal Year: 2007
    ..abstract_text> ..
  37. COAGULATION ACTIVATION IN SICKLE CELL DISEASE
    Kenneth I Ataga; Fiscal Year: 2010
    ..abstract_text> ..
  38. NOVEL NONINDUCIBLE THYMIDYLATE SYNTHASE INHIBITORS
    Aleem Gangjee; Fiscal Year: 2004
    ....
  39. Third Generation Antiopportunistic Agents
    Aleem Gangjee; Fiscal Year: 2003
    ..Screening against tuberculosis (NIAID) and tumor cells in culture (NCI) is also proposed. ..
  40. DISORDERED BLOOD COAGULATION IN SICKLE CELL DISEASE
    Kenneth Ataga; Fiscal Year: 2006
    ..e., is the "hypercoagulability" observed in patients with SCD a primary cause of the vasoocclusion or is it simply a secondary event that is observed in this clinical setting. ..
  41. ROLE OF TGF BETA 1 IN RENAL CANCER
    S Karumanchi; Fiscal Year: 2004
    ..New methodologies the applicant will learn include RNA gel shifts, RNase protection assays, UV crosslinking, mutagenesis, mutation analysis, animal work and immunohistochemistry. ..
  42. Novel Single, Dual and Multitargeted Inhibitors of RTKs
    Aleem Gangjee; Fiscal Year: 2007
    ..abstract_text> ..
  43. Placental Gene Expression Profile in Preeclampsia
    S Karumanchi; Fiscal Year: 2004
    ....
  44. Antitumor Antimitotics That Reverse Tumor Resistance
    Aleem Gangjee; Fiscal Year: 2010
    ..The study will also further define the mechanism of action of the novel series and could afford agents for clinical use. ..
  45. ABNORMAL PRESSURE NATRIURESIS IN HYPERTENSION
    Joey Granger; Fiscal Year: 2009
    ..a decrease in renal medullary production of 20 HETE 3) To test the hypothesis that abnormalities in renal medullary endothelin production and/or ETB receptor function mediate the hypertension in Dahl salt-sensitive rats ..
  46. Renal Microcirculatory and Tubular Dynamics
    Joey Granger; Fiscal Year: 2004
    ....
  47. Hormonal Regulation of Roles of CSF-1 in Reproduction
    Jeffrey Pollard; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  48. CELL SUBPOPULATIONS IN THE PRIMATE CORPUS LUTEUM
    Richard Stouffer; Fiscal Year: 2001
    ..Overall, the proposed research may have relevance to an understanding of certain ovarian disorders such as ovarian hyperstimulation syndrome and luteal phase defects where microvasculature growth may be disrupted. ..
  49. MULTICENTER TRIAL OF SYNSORB PK IN E COLI RELATED HUS
    Howard Trachtman; Fiscal Year: 2003
    ..The outcome of this trial may justify the use of SYNSORB PK as a safe therapy to ameliorate D+HUS. ..
  50. Conference Proposal: Transplantation Immunology
    Angus Thomson; Fiscal Year: 2004
    ..An important goal will be evaluation of future research directions, as well as critical appraisal of contemporary "cutting edge" research. ..
  51. Angiogenesis:Novel Basic Science Insight & Human Therapy
    Napoleone Ferrara; Fiscal Year: 2004
    ..abstract_text> ..
  52. ANGIOGENIC THERAPY FOR INFARCTED AND ISCHEMIC HEART
    Robert Tomanek; Fiscal Year: 2003
    ..Such interventions have a number of advantages over more invasive interventions, e.g., the delivery of oxogenous growth factors or gene therapy. ..
  53. Regulation of Angiogenesis via EphB4 Signaling
    JENA STEINLE; Fiscal Year: 2002
    ..These results from both mesenteric and retinal endothelial cells will greatly increase our understanding of Eph B4 receptor regulation of the various stages of angiogenesis. ..
  54. CHEMOKINE RECEPTORS AND ITP AND HIV THROMBOCYTOPE
    Shahin Rafii; Fiscal Year: 2002
    ..Modulation of chemokine receptors expression by adenoviral vectors overexpressing SDF1, ECDF1 or their receptors may allow for developing therapies to ameliorate thrombocytopenia in vivo. ..
  55. Urothelial Cell Physiology in Normal and Disease States
    Ricardo Saban; Fiscal Year: 2005
    ..Scott-Hultgren (Washington U) will discuss the molecular basis of persistent bladder infections. The bladder cancer discussion will be chaired by Drs. Robert Hurst (Oklahoma U) and Jenny Southgate (U. York). ..
  56. MEDIATORS OF BLOOD-RETINAL BARRIER BREAKDOWN
    STANLEY VINORES; Fiscal Year: 2002
    ....
  57. Sources and Mechanisms of Soluble VEGFR, sFlt Expression in Preeclampsia
    Augustine Rajakumar; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  58. Vascular Endothelial Growth Factor in Hematopoiesis in Cancer
    Mikhail Dikov; Fiscal Year: 2008
    ..abstract_text> ..
  59. The Biology and Function of BMP-7 in the Kidney
    Raghu Kalluri; Fiscal Year: 2007
    ..The physiological role of BMP-7 in kidney health and pathology will be established. These studies will directly benefit the development of this molecule in the clinic as a drug for patients with kidney fibrosis. ..
  60. Matrix Microenvironment and Liver Fibrosis
    Raghu Kalluri; Fiscal Year: 2007
    ..Therefore, this application is well poised to identify a unique mechanism of liver fibrosis and also study a therapeutic agent, which works against this mechanism and inhibits progression of liver disease. ..
  61. International Network and Registry for TMA
    Howard Trachtman; Fiscal Year: 2007
    ..These include essential hypertension, diabetes, hyperlipidemia, myocardial infarction, and chronic kidney disease. [unreadable] [unreadable]..
  62. Phase I Clinical Trials of Anti-Cancer Agents
    Francis Giles; Fiscal Year: 2007
    ..abstract_text> ..
  63. Molecular Targets in Bronchopulmonary Dysplasia
    Richard Pierce; Fiscal Year: 2006
    ..These studies will be highly interactive within the Consortium and provide gene expression data for the scientific community at large. ..
  64. LPS-PEPTIDE INTERACTION IN BLADDER INFLAMMATION
    Ricardo Saban; Fiscal Year: 2007
    ..Information generated by this study should elucidate whether bladder inflammatory responses, regardless of etiology, occur via a common mechanism or whether the endpoints are specific for each stimulus. ..
  65. Activation of eNOS by Steroid Hormones
    James Liao; Fiscal Year: 2006
    ....