Genomes and Genes
Summary: A protein-tyrosine kinase receptor that is specific for NERVE GROWTH FACTOR; NEUROTROPHIN 3; neurotrophin 4, neurotrophin 5. It plays a crucial role in pain sensation and thermoregulation in humans. Gene mutations that cause loss of receptor function are associated with congenital insensitivity to pain with anhidrosis, while gene rearrangements that activate the protein-tyrosine kinase function are associated with tumorigenesis.
Publications226 found, 100 shown here
- Tyrosine phosphorylation and tyrosine kinase activity of the trk proto-oncogene product induced by NGFD R Kaplan
Eukaryotic Signal Transduction Group, NCI Frederick Cancer Research and Development Center, Maryland 21701
Nature 350:158-60. 1991..Activation of the trk tyrosine kinase receptor provides a possible mechanism for signal transduction by NGF...
- NGF signaling in sensory neurons: evidence that early endosomes carry NGF retrograde signalsJean Dominique Delcroix
Department of Neurology and Neurological Sciences, Stanford University, Stanford 94305, USA
Neuron 39:69-84. 2003..Our results are evidence that signaling endosomes, with the characteristics of early endosomes, convey NGF signals from the target of nociceptive neurons to their cell bodies...
- CCM2 mediates death signaling by the TrkA receptor tyrosine kinaseLiraz Harel
Department of Biological Chemistry, Weizmann Institute of Science, 76100 Rehovot, Israel
Neuron 63:585-91. 2009The TrkA receptor tyrosine kinase is crucial for differentiation and survival of nerve-growth-factor-dependent neurons. Paradoxically, TrkA also induces cell death in pediatric tumor cells of neural origin, via an unknown mechanism...
- Nerve growth factor effect on human primary fibroblastic-keratocytes: possible mechanism during corneal healingAlessandra Micera
CIR Laboratory of Ophthalmology, University Campus Bio Medico and G B Bietti, Foundation, Via Emilio Longoni 83, 00155 Rome, Italy
Exp Eye Res 83:747-57. 2006..To sum up, the findings of this study indicate that NGF can modulate some functional activities of fibroblastic-keratocytes, thus substantiating the healing effects of NGF on corneal wound-healing...
- The trk proto-oncogene encodes a receptor for nerve growth factorR Klein
Department of Molecular Biology, Bristol Myers Squibb Pharmaceutical Research Institute, Princeton, New Jersey 08543 4000
Cell 65:189-97. 1991..These results indicate that gp140trk is a functional NGF receptor that mediates at least some of the signal transduction processes initiated by this neurotrophic factor...
- A central role for Islet1 in sensory neuron development linking sensory and spinal gene regulatory programsYunfu Sun
Department of Medicine, University of California San Diego, La Jolla, California 93093, USA
Nat Neurosci 11:1283-93. 2008..Together these results establish a central role for Islet1 in the transition from sensory neurogenesis to subtype specification...
- TrkA alternative splicing: a regulated tumor-promoting switch in human neuroblastomaAntonella Tacconelli
Department of Experimental Medicine, University of L Aquila, Via Vetoio, Coppito 2, 67100 L Aquila, Italy
Cancer Cell 6:347-60. 2004....
- Severe sensory and sympathetic neuropathies in mice carrying a disrupted Trk/NGF receptor geneR J Smeyne
Department of Molecular Biology, Bristol Myers Squibb Pharmaceutical Research Institute, Princeton, New Jersey 08543 4000
Nature 368:246-9. 1994..These findings demonstrate that Trk is the primary mediator of the trophic actions of NGF in vivo and that this signalling pathway plays a crucial role in the development of both the peripheral and the central nervous systems...
- NGF signaling from clathrin-coated vesicles: evidence that signaling endosomes serve as a platform for the Ras-MAPK pathwayC L Howe
Department of Neurology, Stanford University Medical Center, 1201 Welch Road, MSLS P211, Stanford, CA 94305, USA
Neuron 32:801-14. 2001..Our results point to the existence of a population of signaling endosomes derived from clathrin-coated membranes in NGF-treated cells...
- The p75 neurotrophin receptor mediates neuronal apoptosis and is essential for naturally occurring sympathetic neuron deathS X Bamji
Center for Neuronal Survival, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada H3A 2B4
J Cell Biol 140:911-23. 1998..Together, these data indicate that p75NTR can signal to mediate apoptosis, and that this mechanism is essential for naturally occurring sympathetic neuron death...
- Crystal structure of nerve growth factor in complex with the ligand-binding domain of the TrkA receptorC Wiesmann
Department of Protein Engineering, Genentech, Inc, South San Francisco, California 94080, USA
Nature 401:184-8. 1999....
- Nerve growth factor stimulates proliferation and survival of human breast cancer cells through two distinct signaling pathwaysS Descamps
Equipe Facteurs de Croissance, , , 59655 Villeneuve d' ASCQ France
J Biol Chem 276:17864-70. 2001..These data show that two distinct signaling pathways are required for NGF activity and confirm the roles played by p75(NTR) and NF-kappaB in the activation of the survival pathway in breast cancer cells...
- Biological effects of TrkA and TrkB receptor signaling in neuroblastomaAlexander Schramm
Division of Hematology Oncology and Endocrinology, University Children s Hospital of Essen, Hufelandstrasse 55, 45122 Essen, Germany
Cancer Lett 228:143-53. 2005..This short review discusses recent data on the biological roles of TrkA and TrkB signaling in neuroblastoma...
- A novel p75 neurotrophin receptor-related protein, NRH2, regulates nerve growth factor binding to the TrkA receptorSimon S Murray
Skirball Institute of Bimolecular Medicine, New York University School of Medicine, New York, New York 10016, USA
J Neurosci 24:2742-9. 2004..Coexpression of NRH2 with TrkA receptors resulted in the formation of high-affinity binding sites for NGF. These results indicate that a transmembrane protein related to p75NTR is capable of modulating Trk receptor binding properties...
- Differential endocytic sorting of p75NTR and TrkA in response to NGF: a role for late endosomes in TrkA traffickingSmita Saxena
Division of Neuropathology, Institute of Pathology, University of Bern, CH 3010 Bern, Switzerland
Mol Cell Neurosci 28:571-87. 2005..Disrupting p75NTR recycling diminished TrkA activation in response to low concentrations of NGF, demonstrating a functional role for the recycling of p75NTR...
- Nerve growth factor displays stimulatory effects on human skin and lung fibroblasts, demonstrating a direct role for this factor in tissue repairA Micera
Department of Pharmacology, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 91120, Israel
Proc Natl Acad Sci U S A 98:6162-7. 2001..These data show a direct pro-fibrogenic effect of NGF on skin and lung fibroblasts and therefore indicate a role for NGF in tissue repair and fibrosis...
- ProNGF inhibits NGF-mediated TrkA activation in PC12 cellsBettina Sobottka
F Hoffmann La Roche Ltd, CNS Preclinical Research, Grenzacherstrasse 124, 4070 Basel, Switzerland
J Neurochem 107:1294-303. 2008..In this study, we show that proNGF can mediate TrkA receptor signaling directly, yet in the manner of a partial agonist with a lower maximum activity than NGF...
- Ligand-induced internalization of the p75 neurotrophin receptor: a slow route to the signaling endosomeFrancisca C Bronfman
Molecular Neurobiology Group, Department of Biological Chemistry, Weizmann Institute of Science, 76100 Rehovot, Israel
J Neurosci 23:3209-20. 2003..These data suggest that signaling endosomes containing activated p75 are involved in neurotrophin signaling, and that such endosomes may be temporally and spatially distinct from those containing trk receptors...
- Molecular kinetics of nerve growth factor receptor trafficking and activationJerome Jullien
Differentiation and Cell Cycle Group, Laboratoire de Biologie Moleculaire et Cellulaire, CNRS UMR 5665, Ecole Normale Superieure de Lyon, 46 allee d Italie, 69364 Lyon Cedex 07, France
J Biol Chem 277:38700-8. 2002..Together, these data show that the primary effect of NGF treatment is a p75(NTR)-modulated decrease in TrkA transit time at the cell surface...
- The Chagas' disease parasite Trypanosoma cruzi exploits nerve growth factor receptor TrkA to infect mammalian hostsMilena de Melo-Jorge
Parasitology Research Center, Department of Pathology, Tufts University School of Medicine, 150 Harrison Avenue, Boston, MA 02111, USA
Cell Host Microbe 1:251-61. 2007..Thus, TrkA, the nerve growth factor receptor commonly associated with neural survival and protection, may also underlie clinical progression of an important human parasitic disease...
- Molecular basis of congenital insensitivity to pain with anhidrosis (CIPA): mutations and polymorphisms in TRKA (NTRK1) gene encoding the receptor tyrosine kinase for nerve growth factorY Indo
Department of Pediatrics, Kumamoto University School of Medicine, Kumamoto, Japan
Hum Mutat 18:462-71. 2001..Defects in NGF signal transduction at the TRKA receptor lead to failure to support survival of sympathetic ganglion neurons and nociceptive sensory neurons derived ..
- Characterization of neurotrophin and Trk receptor functions in developing sensory ganglia: direct NT-3 activation of TrkB neurons in vivoI Farinas
Department of Physiology, University of California, San Francisco 94143, USA
Neuron 21:325-34. 1998..Results also indicate that survival of cells expressing both receptors can be maintained by activation of either one alone. NT-3 can thus activate more than one Trk receptor in vivo, which when coexpressed are functionally redundant...
- Identification of a zinc finger protein whose subcellular distribution is regulated by serum and nerve growth factorA Chittka
Cell Biology Program, Weill Graduate School of Cornell University Medical College, New York, NY 10021, USA
Proc Natl Acad Sci U S A 96:10705-10. 1999..The translocation of SC-1 to the nucleus was specific for p75, as NGF binding to the TrkA receptor did not lead to nuclear localization of SC-1...
- The trk tyrosine protein kinase mediates the mitogenic properties of nerve growth factor and neurotrophin-3C Cordon-Cardo
Department of Molecular Biology, Bristol Myers Squibb Pharmaceutical Research Institute, Princeton, New Jersey 08543 4000
Cell 66:173-83. 1991..These results indicate that the product of the trk proto-oncogene is sufficient to mediate signal transduction processes induced by NGF and NT-3, at least in proliferating cells...
- TrkA receptor activation by nerve growth factor induces shedding of the p75 neurotrophin receptor followed by endosomal gamma-secretase-mediated release of the p75 intracellular domainSoledad Urra
Department of Physiology, Center for Cellular Regulation and Pathology Joaquin V Luco, Faculty of Biological Sciences, Pontificia Universidad Catolica, Alameda 340, Santiago 8320000, Chile
J Biol Chem 282:7606-15. 2007..We demonstrate that activation of the TrkA receptor upon binding of nerve growth factor (NGF) regulates the metalloprotease-mediated shedding of p75 leaving a ..
- Expression of Trk tyrosine kinase receptor is a biologic marker for cell proliferation and perineural invasion of human pancreatic ductal adenocarcinomaY Sakamoto
Department of Surgery, Saga Medical School, Saga 849 8501, Japan
Oncol Rep 8:477-84. 2001..The present findings revealed a novel mechanism in PDAC progression that is mediated via a NTs-Trk interaction...
- Runx1 determines nociceptive sensory neuron phenotype and is required for thermal and neuropathic painChih Li Chen
Dana Farber Cancer Institute and Department of Neurobiology, Harvard Medical School, 1 Jimmy Fund Way, Boston, Massachusetts 02115, USA
Neuron 49:365-77. 2006..Moreover, mice lacking Runx1 exhibit specific defects in thermal and neuropathic pain. Thus, Runx1 coordinates the phenotype of a large cohort of nociceptors, a finding with implications for pain therapy...
- Grit, a GTPase-activating protein for the Rho family, regulates neurite extension through association with the TrkA receptor and N-Shc and CrkL/Crk adapter moleculesTakeshi Nakamura
Department of Molecular Genetics, National Institute for Longevity Sciences, Program of Protecting the Brain, CREST, JST, Oobu, Aichi 474 8522, Japan
Mol Cell Biol 22:8721-34. 2002..These results suggest that Grit, a novel TrkA-interacting protein, regulates neurite outgrowth by modulating the Rho family of small GTPases...
- A TrkA-selective, fast internalizing nerve growth factor-antibody complex induces trophic but not neuritogenic signalsH U Saragovi
Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec H3G 1Y6, Canada
J Biol Chem 273:34933-40. 1998..mAb does not. Thus, an absolute separation of trophic and neuritogenic function is seen for NGF.mAb, suggesting that biological response modifiers of neurotrophins can afford ligands with selected activities...
- Production of nerve growth factor by mouse hepatocellular carcinoma cells and expression of TrkA in tumor-associated arteries in miceKan Kishibe
Department of Pathology, Asahikawa Medical College, Midorigaoka, Japan
Gastroenterology 122:1978-86. 2002..We found that NGF is specifically elevated in mouse hepatocellular carcinomas (HCCs) by cDNA array analysis. The present study aimed to elucidate expression of NGF and its receptors during hepatocarcinogenesis and under other conditions...
- Proneurotrophins require endocytosis and intracellular proteolysis to induce TrkA activationJacqueline Boutilier
Department of Neurology and Neurosurgery, McGill University, Montreal Neurological Institute, Montreal H3A 2B4, Canada
J Biol Chem 283:12709-16. 2008..However, endocytosis and cleavage of proneurotrophins produce processed forms of neurotrophins that are capable of inducing Trk activation...
- TrkC kinase expression in distinct subsets of cutaneous trigeminal innervation and nonneuronal cellsUrsula Funfschilling
Program in Neuroscience, Department of Physiology, Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, California 94143 0723, USA
J Comp Neurol 480:392-414. 2004..Many types of nonneuronal cells affiliated with hair follicles and blood vessels also express TrkC-reporter but lack immunodetectable TrkC...
- Autophagic cell death induced by TrkA receptor activation in human glioblastoma cellsKatharina Hansen
Department of Neurosurgery, University Medical Center Hamburg Eppendorf, Martinistrasse, Hamburg, Germany
J Neurochem 103:259-75. 2007..Our findings suggest that TrkA activation in human glioblastomas might be beneficial therapeutically, especially as several of the currently used chemotherapeutics also induce autophagic cell death...
- Trk receptor tyrosine kinases: a bridge between cancer and neural developmentA Nakagawara
Division of Biochemistry, Chiba Cancer Center Research Institute, 666 2 Nitona, Chuoh ku, 260 8717, Chiba, Japan
Cancer Lett 169:107-14. 2001..In this short review, the dynamic role of the Trk family receptors signaling in neural development, neurogenic tumors and other cancers will be discussed...
- A synthetic peptide modeled on PDNF, Chagas' disease parasite neurotrophic factor, promotes survival and differentiation of neuronal cells through TrkA receptorMarina V Chuenkova
Parasitology Research Center, Department of Pathology, Tufts University School of Medicine, 150 Harrison Avenue, Boston, Massachusetts 02111, USA
Biochemistry 44:15685-94. 2005....
- Nerve growth factor enhances cough and airway obstruction via TrkA receptor- and TRPV1-dependent mechanismsA Z El-Hashim
Department of Applied Therapeutics, Faculty of Pharmacy, Kuwait University, Safat 13110, Kuwait
Thorax 64:791-7. 2009..Nerve growth factor (NGF) is an important mediator of airway hyper-responsiveness and hyperalgesia but its role in cough is unknown...
- Neutralization of NGF-TrkA receptor interaction by the novel antagonistic anti-TrkA monoclonal antibody MNAC13: a structural insightSonia Covaceuszach
LaylineGenomics, Roma, Italy
Proteins 58:717-27. 2005..The structure of the MNAC13 Fab fragment may assist in the rational structure-based design of high affinity humanized forms of MNAC13, appropriate for therapeutic approaches in neuropathy and inflammatory pain states...
- Activation of the specific neurotrophin receptors TrkA, TrkB and TrkC influences the function of eosinophilsO Noga
Allergy and Asthma Clinic, Charite, Campus Virchow, Humboldt University, Berlin, Germany
Clin Exp Allergy 32:1348-54. 2002..Recent studies have shown that nerve growth factor (NGF) can act on several immune cells as well as residential cells. But little is known about their role in modulating eosinophil function via activation of high-affinity receptors...
- Expression and activation of the nerve growth factor receptor TrkA in serous ovarian carcinomaBen Davidson
Department of Pathology, The Norwegian Radium Hospital, Montebello N 0310 Oslo, Norway
Clin Cancer Res 9:2248-59. 2003..In addition, we wished to study the possible link between expression of NGF, a novel angiogenic factor and its receptor TrkA, and the expression of factors involved in angiogenesis in effusions and solid tumors...
- Survival of cholinergic forebrain neurons in developing p75NGFR-deficient miceC E Van der Zee
Department of Anatomy and Neurobiology, Tupper Building, Dalhousie University, Halifax, Nova Scotia B3H 4H7, Canada
Science 274:1729-32. 1996..Apparently, p75(NGFR) mediates apoptosis of these developing neurons in the absence of TrkA, and modulation of p75(NGFR) can promote neuronal survival. Cholinergic basal forebrain neurons are involved in learning and memory...
- Immunohistochemical evaluation of the protein expression of nerve growth factor and its TrkA receptor in rat limbic regions following electroshock seizuresGiuseppe Conti
Department of Pharmacology, Georgetown University, Washington, DC 20057, USA
Neurosci Res 65:201-9. 2009..The neuroprotective action of NGF is mediated by the TrkA receptor. This study determined whether repeated ECS exposure increased TrkA and NGF protein levels...
- The signaling adapter FRS-2 competes with Shc for binding to the nerve growth factor receptor TrkA. A model for discriminating proliferation and differentiationS O Meakin
Neurodegeneration Research Group, The John P Robarts Research Institute, London, Ontario N6A 5K8, Canada
J Biol Chem 274:9861-70. 1999..Importantly, overexpression of FRS-2 in cells expressing an NGF nonresponsive TrkA receptor mutant reconstitutes the ability of NGF to stop cell cycle progression and to stimulate neuronal ..
- Nerve growth factor activates persistent Rap1 signaling in endosomesC Wu
Departments of Neurology and Neurological Sciences and of Pediatrics and the Program in Neuroscience, Stanford University School of Medicine, Stanford, California 94305, USA
J Neurosci 21:5406-16. 2001..We propose that endosomes are a site from which NGF induces the prolonged activation of Rap1 and MAPK...
- Cell surface Trk receptors mediate NGF-induced survival while internalized receptors regulate NGF-induced differentiationY Zhang
Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA
J Neurosci 20:5671-8. 2000..Thus, interactions between Trk receptor tyrosine kinases and intracellular signaling molecules are dictated both by phosphotyrosine motifs within the receptors and by the intracellular location of phosphorylated receptors...
- NGF regulates the expression of axonal LINGO-1 to inhibit oligodendrocyte differentiation and myelinationXinhua Lee
Department of Discovery Biology, Biogen Idec, Cambridge, Massachusetts 02142, USA
J Neurosci 27:220-5. 2007..The implications of these results relate specifically to the development of potential therapeutics targeting extrinsic growth factors that may regulate the axonal expression of modulators of oligodendrocyte development...
- Identification of a switch in neurotrophin signaling by selective tyrosine phosphorylationJuan Carlos Arevalo
Molecular Neurobiology Program, Skirball Institute of Biomolecular Medicine, Department of Cell Biology, New York University School of Medicine, NY 10016, USA
J Biol Chem 281:1001-7. 2006..Therefore, Trk receptor signaling involves an inducible switch mechanism through an unconventional substrate that distinguishes neurotrophin action from other growth factor receptors...
- The nerve growth factor precursor proNGF exhibits neurotrophic activity but is less active than mature nerve growth factorMargaret Fahnestock
Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario, Canada
J Neurochem 89:581-92. 2004..These data, coupled with our previous report that proNGF is the major form of NGF in the CNS, suggest that proNGF could be responsible for much of the biological activity normally attributed to mature NGF in vivo...
- Nerve growth factor expression and innervation of the painful intervertebral discA J Freemont
Manchester University, UK
J Pathol 197:286-92. 2002..These did not express NGF nor did nerves accompany them. These findings show that nociceptive nerve ingrowth into painful IVD is causally linked with NGF production by blood vessels growing into the IVD, from adjacent vertebral bodies...
- Trk-signaling endosomes are generated by Rac-dependent macroendocytosisGregorio Valdez
Department of Neurobiology and Behavior, State University of New York at Stony Brook, Stony Brook, NY 11794 5230, USA
Proc Natl Acad Sci U S A 104:12270-5. 2007..Thus, a population of stable Trk endosomes, formed by specialized macroendocytosis in neurons, provides a privileged endosome-based system for propagation of signals to the nucleus...
- Autophosphorylation of activation loop tyrosines regulates signaling by the TRK nerve growth factor receptorM E Cunningham
Department of Pathology and Center of Neurobiology and Behavior, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
J Biol Chem 272:10957-67. 1997....
- Gambogic amide, a selective agonist for TrkA receptor that possesses robust neurotrophic activity, prevents neuronal cell deathSung Wuk Jang
Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
Proc Natl Acad Sci U S A 104:16329-34. 2007Nerve growth factor (NGF) binds to TrkA receptor and triggers activation of numerous signaling cascades, which play critical roles in neuronal plasticity, survival, and neurite outgrowth...
- Activation of Trk neurotrophin receptor signaling by pituitary adenylate cyclase-activating polypeptidesFrancis S Lee
Department of Psychiatry, Weill Medical College, Cornell University, New York, New York 10021, USA
J Biol Chem 277:9096-102. 2002..This ability may explain several neuroprotective actions of PACAP upon neuronal populations after injury, nerve lesion, or neurotrophin deprivation...
- The Runx1/AML1 transcription factor selectively regulates development and survival of TrkA nociceptive sensory neuronsFrederic Marmigere
Laboratory of Molecular Neurobiology, Karolinska Institute, MBB, Scheeles vag 1, Stockholm, Sweden
Nat Neurosci 9:180-7. 2006..Our data show that Runx1 directs, in a context-dependent manner, key aspects of the establishment of the TrkA(+) nociceptive subclass of neurons...
- Mutation analysis reveals novel sequence variants in NTRK1 in sporadic human medullary thyroid carcinomaO Gimm
Comprehensive Cancer Center, Ohio State University, Columbus 43210, USA
J Clin Endocrinol Metab 84:2784-7. 1999....
- On Trk for retrograde signalingF D Miller
Center for Neuronal Survival and Brain Tumor Research Center, Montreal Neurological Institute, McGill University, 3801 rue University, H3A 2B4, Montreal, Quebec, Canada
Neuron 32:767-70. 2001....
- Constitutively active Src facilitates NGF-induced phosphorylation of TrkA and causes enhancement of the MAPK signaling in SK-N-MC cellsAkinori Tsuruda
Institute for Biological Resources and Functions, National Institute of Advanced Industrial Science and Technology, Tsukuba, Ibaraki 305 8572, Japan
FEBS Lett 560:215-20. 2004..These results suggest that constitutively active Src that associates with TrkA through Grb2 after NGF stimulation participates in TrkA phosphorylation and in turn enhances the mitogen-activated protein kinase signaling in SK-N-MC cells...
- Brn3a regulation of TrkA/NGF receptor expression in developing sensory neuronsLong Ma
Center for Developmental Biology and Kent Waldrep Foundation Center for Basic Research on Nerve Growth and Regeneration, University of Texas Southwestern Medical Center, Dallas, TX 75390 9133, USA
Development 130:3525-34. 2003..Thus, TrkA, a gene that is crucial for the differentiation and survival of sensory nociceptive neurons, requires Brn3a to maintain normal transcriptional activity...
- Identification of Trk binding sites for SHC and phosphatidylinositol 3'-kinase and formation of a multimeric signaling complexA Obermeier
Department of Molecular Biology, Max Planck Institut fur Biochemie, Martinsried, Germany
J Biol Chem 268:22963-6. 1993..In spite of the close proximity of the p85 binding site to that of phospholipase C gamma (Y-785), both target proteins are able to interact with the same receptor molecule simultaneously...
- Tissue-specific alternative splicing generates two isoforms of the trkA receptorP A Barker
Department of Neurobiology, Stanford University, California 94305 5401
J Biol Chem 268:15150-7. 1993The trkA receptor functions as a signal transducing receptor for nerve growth factor. In this report, we show that alternative splicing results in the production of two distinct trkA isoforms in both rats and humans...
- Brn3a and Klf7 cooperate to control TrkA expression in sensory neuronsLei Lei
Center for Developmental Biology and Kent Waldrep Center for Nerve Growth and Regeneration, University of Texas Southwestern Medical Center, Dallas, TX 75390 9133, USA
Dev Biol 300:758-69. 2006..Thus, cooperation between these two transcription factors is required for endogenous TrkA gene expression and the survival of nociceptive sensory neurons...
- Nerve growth factor exerts differential effects on the growth of human pancreatic cancer cellsZ W Zhu
Department of Visceral and Transplantation Surgery, University of Bern, Inselspital, Switzerland
Clin Cancer Res 7:105-12. 2001..These results point to a previously unknown autocrine/paracrine pathway in pancreatic cancer, suggesting that NGF-TrkA interactions are important factors influencing cell growth and spread in this malignancy...
- An evolutionarily conserved transmembrane protein that is a novel downstream target of neurotrophin and ephrin receptorsH Kong
Molecular Neurobiology Program, Skirball Institute for Biomolecular Medicine, New York University School of Medicine, New York, New York, USA
J Neurosci 21:176-85. 2001....
- NGF activates the phosphorylation of MAP1B by GSK3beta through the TrkA receptor and not the p75(NTR) receptorRobert G Goold
The MRC Centre for Developmental Neurobiology, King s College London, London, UK
J Neurochem 87:935-46. 2003..Finally, inhibition of TrkA receptor tyrosine kinase activity in PC12 cells and superior cervical ganglion neurons with K252a potently and dose-..
- Negative regulation of Ros receptor tyrosine kinase signaling. An epithelial function of the SH2 domain protein tyrosine phosphatase SHP-1H Keilhack
Research Unit, Molecular Cell Biology, D 07747 Jena, Germany
J Cell Biol 152:325-34. 2001..Overexpression of SHP-1 results in Ros dephosphorylation and effectively downregulates Ros-dependent proliferation and transformation. We propose that SHP-1 is an important downstream regulator of Ros signaling...
- Changes in retinal expression of neurotrophins and neurotrophin receptors induced by ocular hypertensionMarcelo Rudzinski
Pharmacology and Therapeutics, McGill University, Montreal, QC, Canada
J Neurobiol 58:341-54. 2004..A possible rationale for therapeutic intervention with Trk receptor agonists and p75 receptor antagonists is proposed...
- NGF controls axonal receptivity to myelination by Schwann cells or oligodendrocytesJonah R Chan
Department of Neurobiology, Stanford University School of Medicine, Fairchild Science Building D235, CA 94305, USA
Neuron 43:183-91. 2004..These findings indicate a novel role for growth factors in regulating the receptivity of axons to myelination and reveal that different axonal signals control central and peripheral myelination...
- Nerve growth factor activation of the TrkA receptor induces cell death, by macropinocytosis, in medulloblastoma Daoy cellsChunhui Li
Laboratory of Neural Signalling, The Robarts Research Institute, London, Ontario, Canada
J Neurochem 112:882-99. 2010Ectopic expression of the TrkA receptor tyrosine kinase in tumors of the nervous system can mediate nerve growth factor (NGF)-dependent cell death by apoptosis and /or autophagy...
- Absence of p75NTR causes increased basal forebrain cholinergic neuron size, choline acetyltransferase activity, and target innervationT T Yeo
Department of Neurology, University of California at San Francisco Veterans Affairs Medical Center, San Francisco, California 94121, USA
J Neurosci 17:7594-605. 1997..These findings indicate that p75NTR negatively regulates cholinergic neuronal phenotype of the basal forebrain cholinergic neurons, including cell size, target innervation, and neurotransmitter synthesis...
- Identification and characterization of novel substrates of Trk receptors in developing neuronsX Qian
Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Neuron 21:1017-29. 1998..Together, these observations indicate that rAPS and SH2-B mediate Trk signaling in developing neurons...
- Lbx1 specifies somatosensory association interneurons in the dorsal spinal cordMichael K Gross
Molecular Neurobiology Laboratory, The Salk Institute, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
Neuron 34:535-49. 2002..Lbx1, therefore, plays a critical role in the development of sensory pathways in the spinal cord that relay pain and touch...
- Remodeling of the innervation of pancreatic islets accompanies insulitis preceding onset of diabetes in the NOD mouseSolveig Persson-Sjögren
Department of Integrative Medical Biology, Section for Histology and Cell Biology, Umea University, SE 901 87 Umea, Sweden
J Neuroimmunol 158:128-37. 2005....
- Distinct effects of p75 in mediating actions of neurotrophins on basal forebrain oligodendrocytesYangzhou Du
Department of Neuroscience and Cell Biology, UMDNJ Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
Mol Cell Neurosci 31:366-75. 2006..On the other hand, K252a, an inhibitor of trk receptors, abolished the effects of the neurotrophins, including BDNF. All neurotrophins activated their respective trk receptors...
- Mammalian neurotrophin-4: structure, chromosomal localization, tissue distribution, and receptor specificityN Y Ip
Regeneron Pharmaceuticals, Inc, Tarrytown, NY 10591
Proc Natl Acad Sci U S A 89:3060-4. 1992..However, mammalian NT-4 displays bioactivity and trk receptor specificity similar to that of Xenopus NT-4...
- Expression of NGF, Trka and p75 in human cartilageA Gigante
Clinica Ortopedica, Universita di Ancona, Via Tronto 10, 60020 Torrette di Ancona, Italy
Eur J Histochem 47:339-44. 2003....
- Nerve growth factor induces vascular endothelial growth factor expression in granulosa cells via a trkA receptor/mitogen-activated protein kinase-extracellularly regulated kinase 2-dependent pathwayMarcela Julio-Pieper
Laboratorio de Endocrinología y Biología de la Reproducción, Hospital Clinico Universidad de Chile, Santos Dumont 999 Independencia, Santiago, Chile
J Clin Endocrinol Metab 94:3065-71. 2009..Nerve growth factor (NGF) may be one of these factors, because NGF promotes angiogenesis and synthesis of angiogenic factors in other tissues and is produced by human granulosa cells (hGCs)...
- Neural crest development and neuroblastoma: the genetic and biological linkAkira Nakagawara
Division of Biochemistry, Chiba Cancer Center Research Institute, 666 2 Nitona, Chuoh ku, Chiba 260 8717, Japan
Prog Brain Res 146:233-42. 2004..Thus, the enigmatic clinical behaviors of neuroblastoma are strictly linked to the molecular mechanism of neural crest development...
- The p75 neurotrophin receptor: multiple interactors and numerous functionsJannifer J Gentry
Center for Molecular Neuroscience, Department of Biochemistry, Vanderbilt University Medical School, Nashville, TN 37232, USA
Prog Brain Res 146:25-39. 2004..Here, we review these p75NTR interacting factors and the current evidence as to how they contribute to the functional effects of p75NTR activation...
- Tyr-701 is a new regulatory site for neurotrophin receptor TrkA trafficking and functionYolanda de Pablo
Cell Signaling and Apoptosis Group, Department Ciències Médiques Bàsiques, IRBLLEIDA, Lleida, Spain
J Neurochem 104:124-39. 2008..This is the first evidence that a Tyr residue can simultaneously regulate TrkA receptor trafficking and activity.
- Activation of the ERK1/2 and p38 mitogen-activated protein kinase pathways mediates fibroblast growth factor-induced growth arrest of chondrocytesAngela Raucci
Department of Microbiology, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
J Biol Chem 279:1747-56. 2004..These results indicate that inhibition of chondrocyte proliferation by FGF requires both ERK1/2 and p38 MAPK signaling and also suggest that sustained activation of these pathways is required to achieve growth inhibition...
- Regulated intramembrane proteolysis of the p75 neurotrophin receptor modulates its association with the TrkA receptorKwang Mook Jung
Department of Pathology, Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Center for Neurobiology and Behavior, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
J Biol Chem 278:42161-9. 2003..our studies suggest that gamma-secretase-mediated p75NTR proteolysis plays a role in the formation/disassembly of the p75-TrkA receptor complex by regulating the availability of the p75 TM domain that is required for this interaction.
- Recent advances in hereditary sensory and autonomic neuropathiesKristien Verhoeven
Peripheral Neuropathy Group, Department of Molecular Genetics, Flanders Interuniversity Institute for Biotechnology, University of Antwerp, Antwerpen, Belgium
Curr Opin Neurol 19:474-80. 2006..This review summarizes the genetic advances of hereditary sensory neuropathies and hereditary sensory and autonomic neuropathies, and provides information on phenotype-genotype correlation and on possible underlying pathomechanisms...
- Quantum dots monitor TrkA receptor dynamics in the interior of neural PC12 cellsSujata Sundara Rajan
Department of Biomedical Engineering, Oregon Health and Science University, Beaverton, Oregon 97006 8921, USA
Nano Lett 6:2049-59. 2006..QDs are contained in microtubule-associated vesicles and possess transport properties that reflect TrkA receptor dynamics...
- Molecular genetics of hereditary sensory neuropathiesMichaela Auer-Grumbach
Department of Internal Medicine, Medical Research Center, Medical University of Graz, Stiftingtalstrasse 24, A 8010 Graz, Austria
Neuromolecular Med 8:147-58. 2006..Nevertheless, it remains unclear how mutations in the known genes lead to the phenotype of HSN. In this review, we summarize the recent progress of the molecular genetics of the HSN and the implicated genes...
- Runx1 selectively regulates cell fate specification and axonal projections of dorsal root ganglion neuronsMasaaki Yoshikawa
Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1 1 1 Tennodai, Tsukuba 305 8577, Japan
Dev Biol 303:663-74. 2007..Our results suggest that Runx1 is involved in the cell fate specification of cutaneous neurons, as well as their projections to central and peripheral targets...
- The small GTPase Rab7 controls the endosomal trafficking and neuritogenic signaling of the nerve growth factor receptor TrkASmita Saxena
Abteilung Neuropathologie, Institut fur Pathologie, Universitat Bern, CH 3010 Bern, Switzerland
J Neurosci 25:10930-40. 2005Nerve growth factor (NGF) and its TrkA receptor exert important bioactivities on neuronal cells such as promoting survival and neurite outgrowth...
- Nerve growth factor helps protect retina in experimental retinal detachmentXiaodong Sun
Eye Research Institute of Shanghai JiaoTong University, Shanghai, China
Ophthalmologica 222:58-61. 2008..To investigate the expression of nerve growth factor (NGF) and its receptor TrkA on the retina at different time points after retinal detachment (RD) and the protection effect of NGF in experimental RD...
- Involvement of neurotrophins and their receptors in spondyloarthritis synovitis: relation to inflammation and response to treatmentM Rihl
Hannover Medical School MHH, Department of Rheumatology OE 6850, Carl Neuberg Str 1, 30625 Hannover, Germany
Ann Rheum Dis 64:1542-9. 2005..To investigate whether expression of the four members of the neurotrophin (NT) family and their four corresponding receptors is related to synovial inflammation in patients with spondyloarthritis (SpA)...
- Oncogenic rearrangements of the NTRK1/NGF receptorMarco A Pierotti
Department of Experimental Oncology and Labs Operative Unit 3, Istituto Nazionale Tumori, Via G Venezian, 1 20133 Milan, Italy
Cancer Lett 232:90-8. 2006..The modalities of their activation, their mechanism of action, the contribution of activating sequences, and the molecular mechanisms underlying their generation will be discussed...
- Retinal p75 and bax overexpression is associated with retinal ganglion cells apoptosis in a rat model of glaucomaMarco Coassin
CIR, Laboratory of Ophthalmology, University Campus Bio Medico, Via Alvaro del Portillo, 21, 00128, Rome, Italy
Graefes Arch Clin Exp Ophthalmol 246:1743-9. 2008..Therefore, this study sought to address whether timely changes in NGF and its receptors, trkA(NGFR) and p75(NTR), might explain the progression of retinal damage during experimental glaucoma...
- Humoral immunodeficiency in congenital insensitivity to pain with anhidrosisSara Sebnem Kilic
Department of Pediatric Immunology, Uludag University School of Medicine, Gorukle, Bursa, 16059, Turkey
Neurogenetics 10:161-5. 2009..The implication of the immune system of the reported patient broadens the clinical phenotype associated with NTRK1 mutations...
- Effect of exogenous administration of nerve growth factor in the retina of rats with inherited retinitis pigmentosaLaura Lenzi
Institute of Neurobiology and Molecular Medicine, Neurobiology Section, CNR, Viale Marx 43 15, 00137 Rome, Italy
Vision Res 45:1491-500. 2005..This suggests that NGF has an effect on RCS rat retina, probably also through the stimulation of other biological mediators produced and released in the retina...
- Origin and evolution of the Trk family of neurotrophic receptorsElia Benito-Gutiérrez
Departament de Genetica, Facultat de Biologia, Universitat de Barcelona, Avinguda Diagonal 645, Barcelona E 08028, Spain
Mol Cell Neurosci 31:179-92. 2006..It is suggestive to propose that subtle protein mutations, gene duplications, and co-options in particular territories of a primitive Nt/Trk system were instrumental to the development of a complex vertebrate nervous system...
- Neurotrophic activities of trk receptors conserved over 600 million years of evolutionGad Beck
Department of Biological Chemistry, Molecular Neurobiology Group, Weizmann Institute of Science, 76100 Rehovot, Israel
J Neurobiol 60:12-20. 2004..Thus, Ltrk is required for neuronal survival, suggesting that trophic activities of the trk receptor family originated before the divergence of molluscan and vertebrate lineages approximately 600 million years ago...
- Neurotrophic factor expression in childhood low-grade astrocytomas and ependymomasAntonio Chiaretti
Paediatric Intensive Care Unit, Catholic University of Sacred Heart, 00168 Rome, Italy
Childs Nerv Syst 20:412-9. 2004..In accordance with the role of neurotrophic factors in tumour behaviour the aim of the present study was to investigate their expression in two childhood brain neoplasms, namely low-grade astrocytomas and ependymomas...
- TrkA receptor "hot spots" for binding of NT-3 as a heterologous ligandLjubica Ivanisevic
Lady Davis Institute Jewish General Hospital, McGill University, Montreal, Quebec H3T 1E2, Canada
J Biol Chem 282:16754-63. 2007..This study demonstrates that Trk signaling is more complex than previously thought because it involves several receptor subdomains and hot spots...
- Decreased first phase insulin response in children with congenital insensitivity to pain with anhidrosisRuth Schreiber
Pediatric Department, Soroka Medical Center and Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
J Pediatr Endocrinol Metab 18:873-7. 2005..Additional studies on the clinical significance of NGF-TrkA effects on insulin secretion are required...
- Proinflammatory cytokines stimulate the expression of nerve growth factor by human intervertebral disc cellsYumiko Abe
Department of Orthopedic Surgery, Rush Medical College at Rush University Medical Center, Chicago IL, USA
Spine (Phila Pa 1976) 32:635-42. 2007..In vitro studies of the effects of proinflammatory cytokines on the production of nerve growth factor (NGF) by human intervertebral disc (IVD) cells...
- Neurotrophin signalling in health and diseaseMoses V Chao
Molecular Neurobiology Program, Skirball Institute of Biomolecular Medicine, Department of Cell Biology, New York University School of Medicine, New York, New York 10016, USA
Clin Sci (Lond) 110:167-73. 2006..In this review, we consider the signalling pathways activated by neurotrophins in both health and disease states...
- High-affinity NGF binding requires coexpression of the trk proto-oncogene and the low-affinity NGF receptorB L Hempstead
Department of Medicine, Cornell University Medical College, New York, New York 10021
Nature 350:678-83. 1991..These studies reveal a new growth factor receptor-mediated mechanism of cellular differentiation involving trk and the low-affinity NGF receptor...
- Congenital insensitivity to pain with anhidrosis (CIPA) in Israeli-Bedouins: genetic heterogeneity, novel mutations in the TRKA/NGF receptor gene, clinical findings, and results of nerve conduction studiesS Shatzky
Genetics Institute, Soroka University Medical Center and the Faculty of Health Sciences, Ben Gurion University, Beer Sheva, Israel
Am J Med Genet 92:353-60. 2000..Three polymorphisms in the TrkA protein kinase encoding domain were also observed...
- Trafficking of TrkA-green fluorescent protein chimerae during nerve growth factor-induced differentiationJerome Jullien
Differentiation and Cell Cycle Group, Laboratoire de Biologie Moleculaire et Cellulaire, UMR 5665 CNRS, Ecole Normale Superieure de Lyon, France
J Biol Chem 278:8706-16. 2003..This approach and the fidelity of the biochemical properties of the TrkA-GFP demonstrate that real-time visualization of trafficking of tyrosine kinase receptors in the presence or absence of the ligand is feasible...
- Imaging NGF signal transduction in live neuronsBianxiao Cui; Fiscal Year: 2010..NGF-lacking endosomes with photo-activatable green fluorescence proteins that are fused to the C-terminal of TrkA receptor. 3...
- Neurotrophin mechanisms in neural development and diseaseRejji Kuruvilla; Fiscal Year: 2013..that two different neurotrophins, Nerve Growth Factor (NGF) and Neurotrophin-3 (NT-3), employ the same TrkA receptor to promote sequential stages of axonal growth during sympathetic nervous system development...
- Remark bundle structure and function in neuropathic painJohn W Griffin; Fiscal Year: 2010..changes, new models of selective nociceptor injury, and a new genetically engineered mouse in which a TrkA receptor kinase mutation is "knocked-in" so that the TrkA is blocked in its signaling by a small molecule inhibitor, ..
- BLADDER HYPERACTIVITY AFTER OBSTRUCTION RELIEFWilliam Steers; Fiscal Year: 1999..voiding frequency, and 3) noting if tyrosine kinase inhibitors that block the effects of NGF binding to the trkA receptor prevent myogenic or neural plasticity and urinary frequency...
- Cholinergic and cognitive decline in response to TrkA knockdown using RNAiVinay Parikh; Fiscal Year: 2009..under the control of a RNA polymerase II promoter, and screening of TrkA miRNA sequences for suppression of TrkA receptor expression in rat pheochromocytoma cells...
- Specific targeting of a neuronal subset using a novel chimeric vector pseudotypeCHRISTOPHER TRIMBY; Fiscal Year: 2009..Loop 2 confers the ability of NGF to bind the TrkA receptor, which is a receptor that is primarily expressed on sensory neurons including those projecting from the dorsal ..
- NGF SIGNALING IN MODELS OF AGE RELATED NEURODEGENERATIONWilliam Mobley; Fiscal Year: 2002..in which one copy of the NGF gene has been disrupted, and mice in which both copies of the gene for the NGF TrkA receptor has been knocked-out. 4) To define NGF actions on degenerating BFCNs in Ts65Dn...
- STRUCTURE/FUNCTION OF TRK RECEPTORS FOR NEUROTROPHINSKENNETH NEET; Fiscal Year: 2001..The hypothesis being tested is that multiple subdomains of the extracellular domain of the TrkA receptor simultaneously interact with numerous distinct regions of NGF...
- IDENTIFICATION OF A NOVEL SIGNAL PATHWAY FOR NGFRaymond Birge; Fiscal Year: 2003..In the present application, we shall study the molecular mechanisms by which c-Crk couples the TrkA receptor to the cytoskeleton, with the long-term goal to understand how NGF promotes differentiation and survival...
- NEURAL STEM CELLS AND NEURO-ONCOLOGYLawrence Recht; Fiscal Year: 2002..Project 4 focuses on the ability of Trka receptor transduction to alter the biologic behavior of C6 glioma cells...
- TRK RECEPTORS AND NEUROTROPHINSLuis Parada; Fiscal Year: 2005..the third aim, we will exploit the existence of a TrkA enhancer, to perform structure/function analysis of the TrkA receptor in vivo...
- Combinatorial Approaches to Activators of the NGF Recep*Nicholas Webster; Fiscal Year: 2005..closely related structures would be a valuable resource for the discovery of small molecule activators of the TrkA receptor. In this proposal, we would like to explore this hypothesis by screening this combinatorial library against ..
- TOOLS FOR THE DISSECTION OF PAIN TRANSMISSION PATHWAYSDOUGLAS LAPPI; Fiscal Year: 1999..COMMERCIAL APPLICATIONS: This proposal seeks to develop an immunolesioning tool for neurons that express the TrkA receptor, the signal transduction receptor for NGF...
- Antipsychotics: Temporal Effects on Cognitive FunctionAlvin Terry; Fiscal Year: 2006..unreadable] [unreadable]..
- Cotinine for Cognitive Impairment in Neurological and Neuropsychiatric DisordersAlvin V Terry; Fiscal Year: 2010..The partly translational design of the study will provide results leading to eventual clinical trials with cotinine or a relevant analog. ..
- Trk receptor mediated apoptosis of medulloblastoma cellsPaul Mischel; Fiscal Year: 2005..This team of internationally recognized mentors is committed to helping Dr. Mischel meet all of the aims of this proposal, and to ensure that he develops into an outstanding independent investigator. ..
- Katzir Conference on Life and Death in the Nervous SystemMoses Chao; Fiscal Year: 2008..The meetings have been a very effective means of stimulating new research and attracting new scientists to the field. [unreadable] [unreadable] [unreadable]..
- Glioblastoma - Molecular Analysis for Clinical TrialsPaul Mischel; Fiscal Year: 2009..abstract_text> ..
- TRAINING IN AGE-RELATED NEURODEGENERATIVE DISEASESElliott Mufson; Fiscal Year: 2008..Finally the program will provide a broad-base of knowledge on neurodegenerative disorders as well as other instruction important for enhancing the interpersonal and professional skills of our trainees. ..
- Validating microRNA Analysis in Human Postmortem BrainYogesh Dwivedi; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- Neurotrophic factors and excitabilityGrant Nicol; Fiscal Year: 2007..A fundamental understanding of such events could lead to better designed compounds and therapies to facilitate the treatment of chronic inflammatory conditions. [unreadable] [unreadable]..
- Molecular Targeting and Imaging of Pituitary AdenomasNELSON OYESIKU; Fiscal Year: 2008..These experiments capitalize on our findings of selective overexpression of functional FRa in NF adenomas, thereby translating basic research into clinical application. ..
- BAC-FISH Assays for Sensitive Karyotyping of Cancer CellsHeinz Ulrich Weier; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- Regulation of Neurotrophin Receptor TraffickingFrancis Lee; Fiscal Year: 2008..unreadable] [unreadable]..
- INTERVENTIONS TO PREVENT NOISE INDUCED HEARING LOSSJOSEF MILLER; Fiscal Year: 2007..We will also determine if reduced blood flow potentiates NIHL, in vivo. These studies will define new interventions and synergies at sites along the apoptotic pathway to optimize the prevention of NIHL. ..
- AGRIN GENE EXPRESSIONMartin Smith; Fiscal Year: 2009..The results of these studies, therefore, are likely to be directly relevant to the prevention and treatment of a number of human disorders, such as epilepsy, that disrupt behavior of neural circuits. ..
- Sphingosine 1-Phosphate Receptors and Sensitization of Sensory NeuronsGrant D Nicol; Fiscal Year: 2010..abstract_text> ..
- Pro- and Anti-Nociceptive Actions of P2y Nucleotide Receptors in Sensory NeuronsDerek C Molliver; Fiscal Year: 2010....
- Divergence and maturation of autonomic lineagesSUSAN BIRREN; Fiscal Year: 2009....
- TISSUE ENGINEERING IN THE INNER EARJOSEF MILLER; Fiscal Year: 2005....
- Vascular MechanosensorHeather A Drummond; Fiscal Year: 2010..Results from this proposal will help define the molecular mechanism of myogenic constriction and provide a better understanding of pressure induced end organ damage. ..
- Cholinergic Lesions and Age-Related Cognitive ImpairmentRobert Gibbs; Fiscal Year: 2008..unreadable] [unreadable]..
- Muller glia and neuronal regeneration in the retinaAndy Fischer; Fiscal Year: 2009..This information could be applied to not only stimulate neural regeneration to treat sight-threatening diseases of the retina, but also to control gliosis that may be detrimental to the pathogenesis of retinal disorders. ..
- NEUROENDOCRINOLOGY OF PUBERTY AND SEXUAL DEVELOPMENTSergio R Ojeda; Fiscal Year: 2010..4) To examine the hypothesis that a novel gene, termed EAP-1 (Enhanced At. Puberty-1) belongs - along with TTF-1 - to the hierarchy of controlling genes involved in the transcriptional regulation of the pubertal process. ..
- WORKSHOP/USE OF NONHUMAN PRIMATES/NEUROSCIENCE RESEARCHSergio Ojeda; Fiscal Year: 2002....
- Ethanol, neurotrophins, and thalamocortical matchingSANDRA MOONEY; Fiscal Year: 2006..abstract_text> ..
- A Novel Gene Network Controlling Mammalian PubertySergio Ojeda; Fiscal Year: 2006..Although siRNAs are widely used to perturb gene expression in mammalian cells, the methodology to achieve long-term silencing effects in vivo is still in its infancy. [unreadable] [unreadable]..
- NEUROTROPHIN CONTROL OF REM SLEEPJack Yamuy; Fiscal Year: 2004..This concerted set of experiments will be critical in elucidating the role that neurotrophins play in the control of REM sleep. ..
- Regulated Ligand Access in Control Receptor ProcessesH Wiley; Fiscal Year: 2004..In addition, they should provide some general insights into how other growth factor systems are regulated. ..
- Neuronal mRNA transport & local translation analysisJeffery Twiss; Fiscal Year: 2004..g., spinal motor neurons) and whether we can utilize exogenous agents to increase local axonal protein synthesis for expediting axonal regeneration. ..
- DEVELOPMENT AND MODULATION OF AUTONOMIC SYNAPSESSUSAN BIRREN; Fiscal Year: 2004..These experiments will, for the first time, define the developmental and modulatory roles of NGF at the synaptic level. ..
- CNS/plasma ABeta clearance of anti-ABeta antibodyDavid Holtzman; Fiscal Year: 2003..This will determine how anti-Abeta antibodies influence CNS/plasma Abeta transport exchanges. ..
- IL-6 IN HERPES SIMPLEX VIRUS TYPE 1 OCULAR REACTIVATIONJOHN KRIESEL; Fiscal Year: 2002..Novel and specific viral mutants will be constructed based on the results of HSV-DNA binding and transient expression assays. ..
- INACTIVATION OF SENSITIZATION IN SENSORY NEURONSGrant Nicol; Fiscal Year: 2003..abstract_text> ..
- APOE EFFECT ON CNS NEURONS--ROLE OF LRPDavid Holtzman; Fiscal Year: 2003..These studies with physiological preparations of apoE as well as both in vivo and in vitro models should provide new insights into mechanisms underlying the link between apoE, LRP, ABeta, and Alzheimer's disease. ..
- Molecular Diagnosis Utilizing Cerebrospinal FluidSTEPHEN GINSBERG; Fiscal Year: 2003..abstract_text> ..
- Lesion Induced Synaptic PlasticitySTEPHEN GINSBERG; Fiscal Year: 2004....
- POSTRECEPTOR DYSREGULATION IN DEPRESSIONYogesh Dwivedi; Fiscal Year: 2004..abstract_text> ..
- Neuronal subsets in the geniculate ganglionAlbert Farbman; Fiscal Year: 2005..We shall use in vitro and in vivo methods to relate changes in trk expression during development to other major developmental events. ..
- A Novel Genetic Therapy for Herpes KeratitisJOHN KRIESEL; Fiscal Year: 2006..An ex vivo model of HSV-1 reactivation in explanted mouse trigeminal ganglia is proposed as an efficient means for determining effective strategies for the delay or inhibition of reactivation. ..
- Proteomics of mild cognitive impairment in the elderlySCOTT COUNTS; Fiscal Year: 2006..Both of these factors will be critical for the development of neuroprotective strategies for slowing or preventing cognitive decline in the elderly. ..
- NEUROPATHOLOGY OF THE AGING SYMPATHETIC NERVOUS SYSTEMRobert Schmidt; Fiscal Year: 2006..The results of these experiments should provide insight not only into autonomic dysfunction, but into a variety of pathologic processes in which NAD is a prominent component. ..
- LSM 510 Confocal MicroscopeRobert Gibbs; Fiscal Year: 2006..Acquisition of the requested instrument will eliminate this problem, and will provide the School of Pharmacy with a greatly needed resource. [unreadable] [unreadable] [unreadable]..
- RADIATION INDUCED THYROID CANCERHeinz Ulrich Weier; Fiscal Year: 2002..We will prepare stable cell lines carrying the oncogenic rearrangements for further characterization and distribution. Finally, we will examine the levels and localization of mRNAs with Northern and in situ hybridization analysis. ..
- A New Tool for Targeted Antisense Knockdown in BrainRobert Gibbs; Fiscal Year: 2006..This will be the first time that a targeted antisense knockdown approach will have been developed and used to selectively regulate gene expression within an identified subpopulation of neurons in the adult brain. ..
- Molecular Specifiers of Neural Cell PlasticitySergio Ojeda; Fiscal Year: 2006..abstract_text> ..
- Neuroblastoma Biology and TherapyGARRETT BRODEUR; Fiscal Year: 2007..Furthermore, treatment strategies developed against neuroblastoma may be useful against other tumors in children and adults that are rely on the biological pathways and are affected by these agents. ..
- Synaptic Alterations in the Cerebral Cortex during AgingA Cuello; Fiscal Year: 2005..abstract_text> ..
- ACTIONS OF PROINFLAMMATORY CYTOKINES ON SENSORY NEURONSGrant Nicol; Fiscal Year: 2002..The results of this work can increase the understanding of the cellular mechanisms mediating the interaction between the nervous system and the immune system and thus be applicable to other areas of neurobiology. ..
- Mechanism of Mechanoreceptor Inhibition by AldosteroneHeather Drummond; Fiscal Year: 2006..unreadable] [unreadable]..