tie 2 receptor

Summary

Summary: A TIE receptor tyrosine kinase that is found almost exclusively on ENDOTHELIAL CELLS. It is required for both normal embryonic vascular development (NEOVASCULARIZATION, PHYSIOLOGIC) and tumor angiogenesis (NEOVASCULARIZATION, PATHOLOGIC).

Top Publications

  1. ncbi Angiopoietin-1 inhibits vascular permeability, angiogenesis, and growth of hepatic colon cancer tumors
    Oliver Stoeltzing
    Department of Cancer Biology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Res 63:3370-7. 2003
  2. ncbi Requisite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis
    C Suri
    Regeneron Pharmaceuticals, Inc, Tarrytown, New York 10591, USA
    Cell 87:1171-80. 1996
  3. ncbi Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning
    S Davis
    Regeneron Pharmaceuticals, Inc, Tarrytown, New York 10591, USA
    Cell 87:1161-9. 1996
  4. ncbi Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis
    P C Maisonpierre
    Regeneron Pharmaceuticals Inc, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA
    Science 277:55-60. 1997
  5. ncbi tek, a novel tyrosine kinase gene located on mouse chromosome 4, is expressed in endothelial cells and their presumptive precursors
    D J Dumont
    Division of Molecular and Developmental Biology, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    Oncogene 7:1471-80. 1992
  6. ncbi The Tie-2 ligand angiopoietin-2 is stored in and rapidly released upon stimulation from endothelial cell Weibel-Palade bodies
    Ulrike Fiedler
    Department of Vascular Biology and Angiogenesis Research Tumor Biology Center, Breisacher Str 117, 79106 Freiburg, Germany
    Blood 103:4150-6. 2004
  7. pmc Hepatic expression, synthesis and secretion of a novel fibrinogen/angiopoietin-related protein that prevents endothelial-cell apoptosis
    I Kim
    National Creative Research Initiatives Center for Cardiac Regeneration, Institute of Cardiovascular Research, Chonbuk National University School of Medicine, Chonju, 560 180, Korea
    Biochem J 346:603-10. 2000
  8. ncbi Angiopoietin-1 promotes cardiac and skeletal myocyte survival through integrins
    Susan M Dallabrida
    Division of Vascular Biology, Children s Hospital, Boston, MA 02115, USA
    Circ Res 96:e8-24. 2005
  9. pmc Increased Tie2 expression, enhanced response to angiopoietin-1, and dysregulated angiopoietin-2 expression in hemangioma-derived endothelial cells
    Y Yu
    Surgical Research Laboratory, Department of Surgery, Children s Hospital, Boston, Massachusetts 02115, USA
    Am J Pathol 159:2271-80. 2001
  10. pmc Designed angiopoietin-1 variant, COMP-Ang1, protects against radiation-induced endothelial cell apoptosis
    Chung Hyun Cho
    Biomedical Research Center and Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 305 701, Korea
    Proc Natl Acad Sci U S A 101:5553-8. 2004

Detail Information

Publications210 found, 100 shown here

  1. ncbi Angiopoietin-1 inhibits vascular permeability, angiogenesis, and growth of hepatic colon cancer tumors
    Oliver Stoeltzing
    Department of Cancer Biology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Res 63:3370-7. 2003
    ..Thus, Ang-1 could potentially serve as an antineoplastic or anti-permeability agent for patients with metastatic colorectal cancer...
  2. ncbi Requisite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis
    C Suri
    Regeneron Pharmaceuticals, Inc, Tarrytown, New York 10591, USA
    Cell 87:1171-80. 1996
    ..Angiopoietin-1 seems to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme...
  3. ncbi Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning
    S Davis
    Regeneron Pharmaceuticals, Inc, Tarrytown, New York 10591, USA
    Cell 87:1161-9. 1996
    ..However, its expression in close proximity with developing blood vessels implicates Angiopoietin-1 in endothelial developmental processes...
  4. ncbi Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis
    P C Maisonpierre
    Regeneron Pharmaceuticals Inc, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA
    Science 277:55-60. 1997
    ..Natural antagonists for vertebrate receptor tyrosine kinases are atypical; thus, the discovery of a negative regulator acting on Tie2 emphasizes the need for exquisite regulation of this angiogenic receptor system...
  5. ncbi tek, a novel tyrosine kinase gene located on mouse chromosome 4, is expressed in endothelial cells and their presumptive precursors
    D J Dumont
    Division of Molecular and Developmental Biology, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    Oncogene 7:1471-80. 1992
    ..tek encodes a novel putative receptor tyrosine kinase that may be critically involved in the determination and/or maintenance of cells of the endothelial lineage...
  6. ncbi The Tie-2 ligand angiopoietin-2 is stored in and rapidly released upon stimulation from endothelial cell Weibel-Palade bodies
    Ulrike Fiedler
    Department of Vascular Biology and Angiogenesis Research Tumor Biology Center, Breisacher Str 117, 79106 Freiburg, Germany
    Blood 103:4150-6. 2004
    ....
  7. pmc Hepatic expression, synthesis and secretion of a novel fibrinogen/angiopoietin-related protein that prevents endothelial-cell apoptosis
    I Kim
    National Creative Research Initiatives Center for Cardiac Regeneration, Institute of Cardiovascular Research, Chonbuk National University School of Medicine, Chonju, 560 180, Korea
    Biochem J 346:603-10. 2000
    ..These results suggest that HFARP may exert a protective function on endothelial cells through an endocrine action...
  8. ncbi Angiopoietin-1 promotes cardiac and skeletal myocyte survival through integrins
    Susan M Dallabrida
    Division of Vascular Biology, Children s Hospital, Boston, MA 02115, USA
    Circ Res 96:e8-24. 2005
    ..Angiopoietin-1 may prove therapeutically valuable in cardiac remodeling by supporting myocyte viability and preserving pump function. The full text of this article is available online at http://circres.ahajournals.org...
  9. pmc Increased Tie2 expression, enhanced response to angiopoietin-1, and dysregulated angiopoietin-2 expression in hemangioma-derived endothelial cells
    Y Yu
    Surgical Research Laboratory, Department of Surgery, Children s Hospital, Boston, Massachusetts 02115, USA
    Am J Pathol 159:2271-80. 2001
    ..These findings implicate Tie2 and its ligands Ang1 and Ang2 in the pathogenesis of hemangioma...
  10. pmc Designed angiopoietin-1 variant, COMP-Ang1, protects against radiation-induced endothelial cell apoptosis
    Chung Hyun Cho
    Biomedical Research Center and Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 305 701, Korea
    Proc Natl Acad Sci U S A 101:5553-8. 2004
    ..Thus, COMP-Ang1 could be used as a therapeutic protein for specific protection against endothelial cell injury...
  11. ncbi Angiopoietin-2 is related to tumor angiogenesis in gastric carcinoma: possible in vivo regulation via induction of proteases
    T Etoh
    Department of Surgery, Medical Institute of Bioregulation, Kyushu University, Beppu, Japan
    Cancer Res 61:2145-53. 2001
    ..These data suggest that production of Ang-2 is implicated in tumor development in human gastric cancers. Its production may contribute to tumor angiogenesis by induction of proteases in ECs, which may be enhanced in the presence of VEGF...
  12. ncbi Biological characterization of angiopoietin-3 and angiopoietin-4
    Hyuek Jong Lee
    Biomedical Research Center and Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, Korea
    FASEB J 18:1200-8. 2004
    ..Ang3 and Ang4 both produced potent corneal angiogenesis extending from the limbus across the mouse cornea in vivo. Thus, Ang3 and Ang4 are agonists of Tie2, but mouse Ang3 has strong activity only on endothelial cells of its own species...
  13. ncbi Tie2 receptor ligands, angiopoietin-1 and angiopoietin-2, modulate VEGF-induced postnatal neovascularization
    T Asahara
    Department of Medicine Cardiology, St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, Mass 02135, USA
    Circ Res 83:233-40. 1998
    ..Moreover, these findings provide in vivo evidence that Ang1 promotes vascular network maturation, whereas Ang2 works to initiate neovascularization...
  14. pmc Tyrosine 1101 of Tie2 is the major site of association of p85 and is required for activation of phosphatidylinositol 3-kinase and Akt
    C D Kontos
    Departments of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Mol Cell Biol 18:4131-40. 1998
    ....
  15. pmc Uniform vascular-endothelial-cell-specific gene expression in both embryonic and adult transgenic mice
    T M Schlaeger
    Max Planck Institut fur Physiologische und Klinische Forschung, Bad Nauheim, Germany
    Proc Natl Acad Sci U S A 94:3058-63. 1997
    ..This should, therefore, allow us to determine the molecular mechanisms underlying the vascular-EC-specific expression of the TIE2 gene...
  16. ncbi Identification of a soluble form of the angiopoietin receptor TIE-2 released from endothelial cells and present in human blood
    P Reusch
    Institute of Molecular Oncology, Tumor Biology Center, Freiburg, Germany
    Angiogenesis 4:123-31. 2001
    ..Several factors influencing the shedding process e.g. basic FGF could be identified. Finally, the soluble form of TIE-2 could also be detected in human biological fluids such as sera and plasma from healthy controls...
  17. pmc Targeting neural precursors in the adult brain rescues injured dopamine neurons
    Andreas Androutsellis-Theotokis
    Laboratory of Molecular Biology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 106:13570-5. 2009
    ..The cellular and pharmacological basis of the neuroprotective effects achieved by these single treatments merits further analysis...
  18. ncbi Adaptor ShcA protein binds tyrosine kinase Tie2 receptor and regulates migration and sprouting but not survival of endothelial cells
    Enrica Audero
    Division of Molecular Angiogenesis, Institute for Cancer Research and Treatment IRCC, School of Medicine, University of Torino, 10060 Candiolo, Italy
    J Biol Chem 279:13224-33. 2004
    ....
  19. ncbi Angiopoietins can directly activate endothelial cells and neutrophils to promote proinflammatory responses
    Caroline Lemieux
    Research Center, Montreal Heart Institute, Montreal, QC, Canada H1T 1C8
    Blood 105:1523-30. 2005
    ..Together, our data demonstrate that angiopoietins could promote acute recruitment of leukocytes, which might contribute to facilitate vascular remodeling and angiogenesis...
  20. ncbi Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formation
    T N Sato
    Roche Institute of Molecular Biology, Roche Research Center, Nutley, New Jersey 07110, USA
    Nature 376:70-4. 1995
    ..Our in vivo analyses indicate that the structurally related receptor tyrosine kinases Tie-1 and Tie-2 have important but distinct roles in the formation of blood vessels...
  21. ncbi Expression of angiopoietins and their receptor Tie2 in the bone marrow of patients with acute myeloid leukemia
    Christoph Schliemann
    Department of Medicine Hematology and Oncology, and the IZKF Muenster, University of Muenster, Albert Schweitzer Strasse 33, D 48129 Muenster, Germany
    Haematologica 91:1203-11. 2006
    ..Angiopoietin-1 (Ang-1) and its natural antagonist angiopoietin-2 (Ang-2), both ligands for the receptor tyrosine kinase Tie2, are known to play an essential role in normal and pathological angiogenesis...
  22. ncbi Angiopoietin-1 and angiopoietin-2 share the same binding domains in the Tie-2 receptor involving the first Ig-like loop and the epidermal growth factor-like repeats
    Ulrike Fiedler
    Department of Vascular Biology and Angiogenesis Research, Tumor Biology Center, 79106 Freiburg, Germany
    J Biol Chem 278:1721-7. 2003
    ....
  23. ncbi Angiopoietins assemble distinct Tie2 signalling complexes in endothelial cell-cell and cell-matrix contacts
    Pipsa Saharinen
    Molecular Cancer Biology Laboratory and Ludwig Institute for Cancer Research, Biomedicum Helsinki, University of Helsinki, Haartmaninkatu 8, P O B 63, 00014 Helsinki, Finland
    Nat Cell Biol 10:527-37. 2008
    ..This novel type of cellular microenvironment-dependent receptor tyrosine kinase activation may explain some of the effects of angiopoietins in angiogenesis and vessel stabilization...
  24. pmc The regulation and localization of angiopoietin-1, -2, and their receptor Tie2 in normal and pathologic human placentae
    E G Zhang
    Department of Obstetrics and Gynaecology, University of Cambridge, The Rosie Hospital, England
    Mol Med 7:624-35. 2001
    ..CONCLUSIONS: These data show that the relative levels of Ang-1 and Ang-2 mRNA are regulated by local oxygen tension by different mechanisms and that this may be important during normal human placentation...
  25. ncbi Functional interaction of vascular endothelial-protein-tyrosine phosphatase with the angiopoietin receptor Tie-2
    G Fachinger
    Max Planck Institute for Physiological and Clinical Research, W G Kerckhoff Institute, Department of Molecular Cell Biology, Parkstrasse 1, D 61231 Bad Nauheim, Germany
    Oncogene 18:5948-53. 1999
    ..Based on its potential role as a regulator of blood vessel morphogenesis and maintainance, VE-PTP is a candidate gene for inherited vascular malformations similar to the Tie-2 gene...
  26. ncbi Long-term and sustained COMP-Ang1 induces long-lasting vascular enlargement and enhanced blood flow
    Chung Hyun Cho
    Biomedical Research Center and Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, Korea
    Circ Res 97:86-94. 2005
    ..Sustained overexpression of Tie2 could participate in the maintenance of vascular changes. Together, our findings indicate that sustained treatment with COMP-Ang1 can produce long-lasting vascular enlargement and increased blood flow...
  27. ncbi Vascular endothelial growth factor activates the Tie family of receptor tyrosine kinases
    Harprit Singh
    University of Leicester, Department of Cardiovascular Sciences, RKCSB, PO Box 65, Leicester LE27LX, UK
    Cell Signal 21:1346-50. 2009
    ..This novel mechanism of receptor tyrosine kinase activation is likely to be important in integrating signalling between two of the key receptor groups regulating angiogenesis...
  28. ncbi Plasma angiopoietin-1, angiopoietin-2, and angiopoietin receptor tie-2 levels in congestive heart failure
    Aun Yeong Chong
    Haemostasis Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham B18 7QH, England, UK
    J Am Coll Cardiol 43:423-8. 2004
    ....
  29. ncbi Vasculogenesis and angiogenesis as mechanisms of vascular network formation, growth and remodeling
    S Patan
    Division of Cardiology, Albert Einstein College of Medicine, Yeshiva University, Bronx, New York 10461, USA
    J Neurooncol 50:1-15. 2000
    ..The cellular mechanisms and the molecular regulation of angiogenesis in the pathological state are summarized and the differences of physiological and pathological angiogenesis elaborated...
  30. ncbi Dominant-negative and targeted null mutations in the endothelial receptor tyrosine kinase, tek, reveal a critical role in vasculogenesis of the embryo
    D J Dumont
    Division of Molecular and Developmental Biology, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    Genes Dev 8:1897-909. 1994
    ....
  31. pmc Excess circulating angiopoietin-2 may contribute to pulmonary vascular leak in sepsis in humans
    Samir M Parikh
    Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS Med 3:e46. 2006
    ..We hypothesized that Ang-2 contributes to endothelial barrier disruption in sepsis-associated lung injury, a condition involving the mature vasculature...
  32. ncbi Angiogenesis in embryonic development--a review
    G Breier
    Max Planck Institut for Physiological and Clinical Research, Laboratory of Molecular and Cellular Biology, Bad Nauheim, Germany
    Placenta 21:S11-5. 2000
    ..The complex interactions between these and other endothelial signalling systems are beginning to emerge. Placenta (2000), 21, Supplement A, Trophoblast Research, 14, S11-S15...
  33. ncbi Early effects of hypoxia/reoxygenation on VEGF, ang-1, ang-2 and their receptors in the rat myocardium: implications for myocardial angiogenesis
    P S Ray
    Department of Surgery, University of Connecticut Health Center, Farmington, USA
    Mol Cell Biochem 213:145-53. 2000
    ..The stimulation of myocardial angiogenesis by H/R may constitute a potential basis for a possible more long-lived adaptive response to stress afforded by preconditioning stimuli...
  34. ncbi Expression of the angopoietin-1, angopoietin-2, Tie2, and vascular endothelial growth factor gene in epithelial ovarian cancer
    Kohkichi Hata
    Department of Obstetrics and Gynecology, University School of Medicine, Izumo 693 8501, Japan
    Gynecol Oncol 93:215-22. 2004
    ..The aim was to evaluate whether angiopoietin/Tie2 system with VEFG affects prognosis in patients of epithelial ovarian cancer...
  35. ncbi Soluble Tie2 and Flt1 extracellular domains in serum of patients with renal cancer and response to antiangiogenic therapy
    A L Harris
    Imperial Cancer Research Fund, Molecular Oncology Laboratories, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DS, United Kingdom
    Clin Cancer Res 7:1992-7. 2001
    ..05) and improved survival (P = 0.04). The soluble receptors measured weeks before response were assessed and correlated with response and survival, showing they may be useful to monitor and develop antiangiogenic therapy...
  36. ncbi Angiopoietin 2 stimulates migration and tube-like structure formation of murine brain capillary endothelial cells through c-Fes and c-Fyn
    Yasushi Mochizuki
    Department of Urology, Nagasaki University Graduate School of Medicine, 1 7 1, Sakamoto, Nagasaki 852 8501, Japan
    J Cell Sci 115:175-83. 2002
    ..Collecting these data, Ang2 activates c-Fes and c-Fyn, leading to migration and tube formation by murine capillary endothelial cells...
  37. ncbi Angiopoietin-1 is inversely related to thymidine phosphorylase expression in human breast cancer, indicating a role in vascular remodeling
    M J Currie
    Anatomical Pathology, Canterbury Health, Christchurch Hospital, Christchurch, New Zealand
    Clin Cancer Res 7:918-27. 2001
    ..CONCLUSIONS: These findings suggest that the Ang/Tie2 pathway plays a significant role in human breast tumor angiogenesis but provide no initial evidence for direct regulation of the pathway by estrogen...
  38. ncbi Identification of proangiogenic TIE2-expressing monocytes (TEMs) in human peripheral blood and cancer
    Mary Anna Venneri
    San Raffaele Telethon Institute for Gene Therapy, Milan, Italy
    Blood 109:5276-85. 2007
    ..Human TEMs may provide a novel, biologically relevant marker of angiogenesis and represent a previously unrecognized target of cancer therapy...
  39. ncbi Klf2 is an essential regulator of vascular hemodynamic forces in vivo
    John S Lee
    Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Dev Cell 11:845-57. 2006
    ..These findings identify Klf2 as an essential hemodynamic regulator in vivo and suggest that hemodynamic regulation in response to fluid shear stress is required for cardiovascular development and function...
  40. ncbi The angiopoietin-tie2 system in coronary artery endothelium prevents oxidized low-density lipoprotein-induced apoptosis
    I Kim
    National Creative Research Initiatives Center for Cardiac Regeneration and Institute of Cardiovascular Research, Chonbuk University School of Medicine, Chonju, South Korea
    Cardiovasc Res 49:872-81. 2001
    ..In this study, we explored the biological significance of the angiopoietin-Tie2 system in porcine coronary artery...
  41. ncbi The Tie-2 ligand angiopoietin-2 destabilizes quiescent endothelium through an internal autocrine loop mechanism
    Marion Scharpfenecker
    Department of Vascular Biology and Angiogenesis Research, Tumor Biology Center, 79106 Freiburg, Germany
    J Cell Sci 118:771-80. 2005
    ....
  42. pmc Angiopoietin 2 is a partial agonist/antagonist of Tie2 signaling in the endothelium
    Hai Tao Yuan
    Molecular and Vascular Medicine, Division of Nephrology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Mol Cell Biol 29:2011-22. 2009
    ....
  43. ncbi tie2, a putative protein tyrosine kinase from a new class of cell surface receptor
    A S Runting
    Ludwig Institute for Cancer Research, Post Office Royal Melbourne Hospital, Parkville, Victoria, Australia
    Growth Factors 9:99-105. 1993
    ..The tie2 protein exhibits a high degree of similarity to the cell surface receptor tie, (Partanen, J. et al., (1992) Mol. Cell. Biol., 12, 1698-1707), and together with this protein defines a new class of cell surface receptor...
  44. ncbi Angiopoietin/Tek interactions regulate mmp-9 expression and retinal neovascularization
    Arup Das
    Department of Surgery, University of New Mexico School of Medicine, Albuquerque, New Mexico
    Lab Invest 83:1637-45. 2003
    ..Inhibition of the binding activity of the angiopoietins in vivo suppressed retinal neovascularization concomitant with a reduction in the expression of MMP-9...
  45. ncbi Vascular endothelial cell-specific phosphotyrosine phosphatase (VE-PTP) activity is required for blood vessel development
    Sebastian Baumer
    Max Planck Institute of Molecular Biomedicine, D 48149 Munster, Germany
    Blood 107:4754-62. 2006
    ..No signs for enhanced endothelial apoptosis or proliferation were observed. Thus, the activity of VE-PTP is not required for the initial formation of blood vessels, yet it is essential for their maintenance and remodeling...
  46. pmc Requirement for the TIE family of receptor tyrosine kinases in adult but not fetal hematopoiesis
    Mira C Puri
    Samuel Lunenfeld Research Institute, Program in Molecular Biology and Cancer, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario, Canada M5G 1X5
    Proc Natl Acad Sci U S A 100:12753-8. 2003
    ....
  47. pmc Angiopoietin-2 functions as an autocrine protective factor in stressed endothelial cells
    Christopher Daly
    Regeneron Pharmaceuticals, Inc, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA
    Proc Natl Acad Sci U S A 103:15491-6. 2006
    ..Our data suggests a model in which Ang-2 expression is induced in stressed endothelial cells, where it acts as an autocrine Tie2 agonist and protective factor...
  48. ncbi Differential function of Tie2 at cell-cell contacts and cell-substratum contacts regulated by angiopoietin-1
    Shigetomo Fukuhara
    Department of Structural Analysis, National Cardiovascular Center Research Institute, 5 7 1 Fujishirodai, Suita, Osaka 565 8565, Japan
    Nat Cell Biol 10:513-26. 2008
    ....
  49. pmc Regulated proteolytic processing of Tie1 modulates ligand responsiveness of the receptor-tyrosine kinase Tie2
    Marie B Marron
    Department of Cardiovascular Sciences, University of Leicester, Robert Kilpatrick Clinical Sciences Bld, P O Box 65, Leicester, LE2 7LX United Kingdom
    J Biol Chem 282:30509-17. 2007
    ..Furthermore the data suggest that regulated processing of Tie1 may be an important mechanism for controlling signaling by Tie2...
  50. pmc COMP-Ang1: a designed angiopoietin-1 variant with nonleaky angiogenic activity
    Chung Hyun Cho
    Biomedical Research Center and Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 305 701, Korea
    Proc Natl Acad Sci U S A 101:5547-52. 2004
    ..Thus, COMP-Ang1 is an effective alternative to native Ang1 for therapeutic angiogenesis in vivo...
  51. ncbi Enhanced expression of Tie2, its ligand angiopoietin-1, vascular endothelial growth factor, and CD31 in human non-small cell lung carcinomas
    M Takahama
    Department of Oncological Pathology, Cancer Center, Nara Medical University, Kashihara, Japan
    Clin Cancer Res 5:2506-10. 1999
    ..These findings suggest that Ang-1 and VEGF are important angiogenic factors in human non-small cell lung carcinomas...
  52. ncbi Effects of protein and gene transfer of the angiopoietin-1 fibrinogen-like receptor-binding domain on endothelial and vessel organization
    Cornelia C Weber
    Department of Materials Science, and Institute of Biomedical Engineering, Swiss Federal Institute of Technology Zurich and University of Zurich, Zurich 8044, Switzerland
    J Biol Chem 280:22445-53. 2005
    ..Furthermore, we show that the isolated receptor-binding domain of Ang1 is capable of mediating some effects of full-length Ang1 independently of Tie2 phosphorylation, possibly through integrin ligation...
  53. ncbi Functional significance of Tie2 signaling in the adult vasculature
    Kevin G Peters
    Procter and Gamble Pharmaceuticals, Health Care Research Center, Mason, Ohio 45140, USA
    Recent Prog Horm Res 59:51-71. 2004
    ....
  54. pmc A mutant receptor tyrosine phosphatase, CD148, causes defects in vascular development
    Takamune Takahashi
    Nephrology Division and Center for Vascular Biology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Mol Cell Biol 23:1817-31. 2003
    ..These findings implicate a member of the receptor tyrosine phosphatase family, CD148, in developmental vascular organization and provide evidence that it regulates endothelial proliferation and endothelium-pericyte interactions...
  55. ncbi The angiopoietins and Tie2/Tek: adding to the complexity of cardiovascular development
    Nicole L Ward
    Division of Molecular and Cellular Biology Research, Sunnybrook and Women s College Research Institute, Toronto, Ontario, Canada M4N 3M5
    Semin Cell Dev Biol 13:19-27. 2002
    ..However, what is emerging from genetic, xenograft transplant, histochemical and cell culture experiments are that the response of endothelial cells to angiopoietins appears to be context and endothelial cell type specific...
  56. ncbi Critical role of the TIE2 endothelial cell receptor in the development of definitive hematopoiesis
    N Takakura
    Department of Cell Differentiation, Institute of Molecular Embryology and Genetics, Kumamoto University School of Medicine, Japan
    Immunity 9:677-86. 1998
    ..5 d.p.c. P-Sp. Adhesion of TIE2+ cells induced by Angiopoietin-1 enhanced the proliferation of hematopoietic progenitor cells...
  57. ncbi Regulation of hematopoietic stem cells by the niche
    Fumio Arai
    Department of Cell Differentiation, The Sakaguchi Laboratory of Developmental Biology, School of Medicine, Keio University, Tokyo 160 8582, Japan
    Trends Cardiovasc Med 15:75-9. 2005
    ..Ang-1 produced by OBs activates Tie2 on HSCs and promotes tight adhesion of HSCs to the niche, resulting in quiescence and enhanced survival of HSCs...
  58. ncbi Two independent mechanisms essential for tumor angiogenesis: inhibition of human melanoma xenograft growth by interfering with either the vascular endothelial growth factor receptor pathway or the Tie-2 pathway
    G Siemeister
    Institute of Molecular Medicine, Tumor Biology Center, Frieburg, Germany
    Cancer Res 59:3185-91. 1999
    ..These findings suggest that the VEGF receptor pathway and the Tie-2 pathway have to be considered as two independent mediators essential for the process of in vivo angiogenesis...
  59. ncbi Spatial and temporal distribution of Tie-1 and Tie-2 during very early development of the human placenta
    U A Kayisli
    Department of Histology and Embryology, Faculty of Medicine, Akdeniz University, Antalya, Turkey
    Placenta 27:648-59. 2006
    ..Due to their spatial distribution we speculate on an additional role in regulation of villous and extravillous trophoblastic behavior...
  60. ncbi Disruption of Ang-1/Tie-2 signaling contributes to the impaired myocardial vascular maturation and angiogenesis in type II diabetic mice
    Jian xiong Chen
    Department of Pediatrics, Division of Neonatology, Vanderbilt University Medical Center, MRB IV 1125, Nashville, TN 37232 2650, USA
    Arterioscler Thromb Vasc Biol 28:1606-13. 2008
    ....
  61. ncbi Human podocytes express angiopoietin 1, a potential regulator of glomerular vascular endothelial growth factor
    Simon C Satchell
    Academic Renal Unit, University of Bristol, Southmead Hospital, Bristol, United Kingdom
    J Am Soc Nephrol 13:544-50. 2002
    ....
  62. pmc Circulating angiopoietin 2 correlates with mortality in a surgical population with acute lung injury/adult respiratory distress syndrome
    Diana C Gallagher
    Division of Pulmonary, Critical Care, and Sleep Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Shock 29:656-61. 2008
    ..These data, coupled with our cell culture experiments, suggest that antagonism of Ang2 may provide a future novel therapeutic target for ARDS...
  63. ncbi Vascular dysmorphogenesis caused by an activating mutation in the receptor tyrosine kinase TIE2
    M Vikkula
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cell 87:1181-90. 1996
    ..We conclude that an activating mutation in TIE2 causes inherited VMs in the two families and that the TIE2 signaling pathway is critical for endothelial cell-smooth muscle cell communication in venous morphogenesis...
  64. ncbi Tie2 receptor expression and phosphorylation in cultured cells and mouse tissues
    T I Koblizek
    Department of Molecular Cell Biology, Max Planck Institute for Physiological and Clinical Research, Bad Nauheim, Germany
    Eur J Biochem 244:774-9. 1997
    ..5 post coitum...
  65. ncbi TIE2 gain-of-function mutation in a patient with pancreatic lymphangioma associated with blue rubber-bleb nevus syndrome: report of a case
    Yasuyuki Nobuhara
    Department of Surgical Oncology, Osaka City University Graduate School of Medicine, 1 4 3 Asahi machi, Abeno Ku, Osaka, 545 8585, Japan
    Surg Today 36:283-6. 2006
    ..We describe the clinical features of this case and discuss a possible correlation between these two uncommon conditions...
  66. ncbi VEGF-A, VEGFR-1, VEGFR-2 and Tie2 levels in plasma of premature infants: relationship to retinopathy of prematurity
    C Pieh
    Department of Ophthalmology, University Hospital Freiburg, Freiburg, Germany
    Br J Ophthalmol 92:689-93. 2008
    ..To identify their changes related to the onset of retinopathy of prematurity (ROP)...
  67. ncbi Mechanistic effects of autophosphorylation on receptor tyrosine kinase catalysis: enzymatic characterization of Tie2 and phospho-Tie2
    B W Murray
    Pfizer Global Research and Development La Jolla Laboratories, 4215 Sorrento Valley Boulevard, La Jolla, California 92121, USA
    Biochemistry 40:10243-53. 2001
    ..Tie2 activation perturbs catalytic residue ionizations, shifts the rate-limiting step to almost exclusive diffusion-control, and transforms the kinase into a more perfect catalyst...
  68. ncbi Structure of the Tie2 RTK domain: self-inhibition by the nucleotide binding loop, activation loop, and C-terminal tail
    L M Shewchuk
    Glaxo Wellcome, Research Triangle Park, NC 27709, USA
    Structure 8:1105-13. 2000
    ..Tie2 (also known as Tek) is an endothelium-specific receptor tyrosine kinase involved in both angiogenesis and vasculature maintenance...
  69. ncbi Placental defects in ARNT-knockout conceptus correlate with localized decreases in VEGF-R2, Ang-1, and Tie-2
    B D Abbott
    Reproductive Toxicology Division, National Health and Environmental Effects Research Laboratory, Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Dev Dyn 219:526-38. 2000
    ..5. Published 2000 Wiley-Liss, Inc...
  70. ncbi Disrupted pulmonary vasculature and decreased vascular endothelial growth factor, Flt-1, and TIE-2 in human infants dying with bronchopulmonary dysplasia
    A J Bhatt
    Strong Children's Research Center, Division of Neonatology, Children's Hospital at Strong, Rochester, New York, USA
    Am J Respir Crit Care Med 164:1971-80. 2001
    ..We conclude that infants dying with BPD have abnormal alveolar microvessels and that disordered expression of angiogenic growth factors and their receptors may contribute to these abnormalities...
  71. pmc Expression of Tie2/Tek in breast tumour vasculature provides a new marker for evaluation of tumour angiogenesis
    K G Peters
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Br J Cancer 77:51-6. 1998
    ..004 and 0.0001 respectively). These data are consistent with a role for Tie2 in tumour angiogenesis and demonstrate the potential use of Tie2 expression as a novel marker of the tumour vasculature...
  72. ncbi Expression and function of murine receptor tyrosine kinases, TIE and TEK, in hematopoietic stem cells
    M Yano
    Department of Cell Differentiation, Institute of Molecular Embryology and Genetics IMEG, Kumamoto University School of Medicine, Japan
    Blood 89:4317-26. 1997
    ....
  73. ncbi Tie2: a journey from normal angiogenesis to cancer and beyond
    V Martin
    Department of Neuro Oncology, Brain Tumor Center, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Histol Histopathol 23:773-80. 2008
    ....
  74. ncbi TIE1 and TIE2 receptor tyrosine kinases inversely regulate embryonic angiogenesis by the mechanism of intussusceptive microvascular growth
    S Patan
    Department of Radiation Oncology, Beth Israel Hospital, Boston, Massachusetts, 02114, USA
    Microvasc Res 56:1-21. 1998
    ..Angiopoietin-1, a ligand that activates the TIE2 receptor, is expressed in mesenchymal cells surrounding the endothelium. This local relationship is indicative of a paracrine regulation...
  75. pmc Activation of the tie2 receptor by angiopoietin-1 enhances tumor vessel maturation and impairs squamous cell carcinoma growth
    Thomas Hawighorst
    Cutaneous Biology Research Center, Department of Dermatology, Massachusetts General Hospital and Harvard Medical School, Charlestown 02129, USA
    Am J Pathol 160:1381-92. 2002
    ....
  76. ncbi Angiopoietin-1 promotes lymphatic sprouting and hyperplasia
    Tuomas Tammela
    Molecular Cancer Biology Laboratory, Ludwig Institute for Cancer Research, Biomedicum Helsinki, Finland
    Blood 105:4642-8. 2005
    ..Furthermore, a soluble form of VEGFR-3 inhibited the observed lymphatic sprouting. Our results reinforce the concept that Ang1 therapy may be useful in settings of tissue edema...
  77. ncbi Alterations in expression of angiopoietins and the Tie-2 receptor in the retina of streptozotocin induced diabetic rats
    Hirokazu Ohashi
    Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Mol Vis 10:608-17. 2004
    ..The angiopoietin (Ang)/Tie-2 system may play a role in vascular integrity and angiogenesis. In this study, we investigated alterations of the gene expression of Ang-1 and Ang-2 in the retinas of streptozotocin (STZ) induced diabetic rats...
  78. ncbi Colocalization of Tie2, angiopoietin 2 and vascular endothelial growth factor in fibrovascular membrane from patients with retinopathy of prematurity
    Naoyasu Umeda
    Department of Ophthalmology, Fukuoka University, School of Medicine, Fukuoka, Japan
    Ophthalmic Res 35:217-23. 2003
    ..To elucidate the potential role of Angs and the Tie2 system in retinopathy of prematurity (ROP), we have investigated the expression of Angs, Tie2 and VEGF within fibroproliferative membranes in ROP...
  79. ncbi Overexpression of angiopoietin-1 and angiopoietin-2 in hepatocellular carcinoma
    Takuji Torimura
    Second Department of Medicine, Kurume University School of Medicine, Liver Cancer Division, Research Center for Innovative Cancer Therapy, and Center of the 21st Century COE Program for Medical Science, Kurume University, Fukuoka 830 0011, Japan
    J Hepatol 40:799-807. 2004
    ..Hepatocellular carcinoma (HCC) is a highly vascular tumor. Angiopoietin-1 and Angiopoietin-2 have been shown to be involved in tumor angiogenesis. We investigated the expression of Angiopoietin-1 and Angiopoietin-2 in HCC...
  80. ncbi Structure of the angiopoietin-2 receptor binding domain and identification of surfaces involved in Tie2 recognition
    William A Barton
    Structural Biology Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, New York 10021, USA
    Structure 13:825-32. 2005
    ..The structure reveals a fibrinogen fold with a unique C-terminal P domain. Conservation analysis and structure-based mutagenesis identify a groove on the Ang2 molecular surface that mediates receptor recognition...
  81. ncbi Angiopoietin-2 causes inflammation in vivo by promoting vascular leakage
    Fiorentina Roviezzo
    Laboratory of Molecular Pharmacology, Department of Pharmacy, University of Patras, Patras, Greece 26504
    J Pharmacol Exp Ther 314:738-44. 2005
    ..We conclude that Ang-2 by itself stimulates the extravasation of cell-poor fluid, but in the presence of ongoing inflammation it reduces cellular infiltration in tissues...
  82. pmc Stable interaction between alpha5beta1 integrin and Tie2 tyrosine kinase receptor regulates endothelial cell response to Ang-1
    Ilaria Cascone
    Department of Oncological Sciences and Institute for Cancer Research and Treatment, University of Turin, 10060 Candiolo, Italy
    J Cell Biol 170:993-1004. 2005
    ..By using blocking antibodies, we consistently found that alpha5beta1, but not alphavbeta3 activation, is essential to Ang-1-dependent angiogenesis in vivo...
  83. pmc Multiple angiopoietin recombinant proteins activate the Tie1 receptor tyrosine kinase and promote its interaction with Tie2
    Pipsa Saharinen
    Molecular Cancer Biology Laboratory and Ludwig Institute for Cancer Research, University of Helsinki, Finland
    J Cell Biol 169:239-43. 2005
    ..These results should be important in dissecting the signal transduction pathways and biological functions of Tie1...
  84. ncbi Chemotactic properties of angiopoietin-1 and -2, ligands for the endothelial-specific receptor tyrosine kinase Tie2
    B Witzenbichler
    Department of Cardiovascular Research, St Elizabeth s Medical Center of Boston, Tufts University School of Medicine, Boston, MA 02135, USA
    J Biol Chem 273:18514-21. 1998
    ....
  85. ncbi Hematopoietic stem cells and endothelial cell precursors express Tie-2, CD31 and CD45
    J P Shaw
    Department of Surgery, S A Localio Laboratory for Surgical Research, New York University School of Medicine, New York, NY 10016, USA
    Blood Cells Mol Dis 32:168-75. 2004
    ..Selection of Tie-2+Sca-1+ BMC enriches for marrow-derived EPCs that participate in tumor angiogenesis and cells that can provide hematopoietic reconstitution of marrow-ablated mice...
  86. ncbi The Tek/Tie2 receptor signals through a novel Dok-related docking protein, Dok-R
    N Jones
    Ontario Cancer Institutes and Department of Medical Biophysics, University of Toronto, Canada
    Oncogene 17:1097-108. 1998
    ..The cloning of Dok-R represents the first downstream substrate of the activated Tek receptor, and suggests that Tek can signal through a multitude of pathways...
  87. ncbi Expression of Tie-1 and 2 receptors, and angiopoietin-1, 2 and 4 in gastric carcinoma; immunohistochemical analyses and correlation with clinicopathological factors
    T Nakayama
    Department of Molecular Pathology, Nagasaki University Graduate School of Biomedical Sciences, Sakamoto, Nagasaki, Japan
    Histopathology 44:232-9. 2004
    ..Angiopoietin (Ang)-1 is known as a ligand of the Tie-2 tyrosine kinase receptor. The aim of this study was to determine the expression profile of Tie-1 and 2 and Ang-1, 2 and 4 in gastric adenocarcinoma...
  88. pmc HIF1alpha induces the recruitment of bone marrow-derived vascular modulatory cells to regulate tumor angiogenesis and invasion
    Rose Du
    Department of Neurological Surgery, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA
    Cancer Cell 13:206-20. 2008
    ..VEGF also directly regulates tumor cell invasiveness. When VEGF activity is impaired, tumor cells invade deep into the brain in the perivascular compartment...
  89. ncbi Regulation of angiopoietin expression by bacterial lipopolysaccharide
    Mahroo Mofarrahi
    Critical Care Division, Royal Victoria Hospital, 687 Pine Ave West, Montreal, Quebec, Canada H3A 1A1
    Am J Physiol Lung Cell Mol Physiol 294:L955-63. 2008
    ....
  90. ncbi Interaction of the TEK and TIE receptor tyrosine kinases during cardiovascular development
    M C Puri
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Ontario, Canada M5G 1X5
    Development 126:4569-80. 1999
    ..This analysis demonstrates essential functions for TEK and TIE in maintaining the integrity of the mature vasculature...
  91. pmc Angiopoietin1/Tie2 and VEGF/Flk1 induced by MSC treatment amplifies angiogenesis and vascular stabilization after stroke
    Alex Zacharek
    Department of Neurology, Henry Ford Health Sciences Center, Detroit, Michigan, USA
    J Cereb Blood Flow Metab 27:1684-91. 2007
    ..Our data indicate MSC treatment of stroke promotes angiogenesis and vascular stabilization, which is at least partially mediated by VEGF/Flk1 and Ang1/Tie2...
  92. ncbi Angiopoietin-1 and -2 coiled coil domains mediate distinct homo-oligomerization patterns, but fibrinogen-like domains mediate ligand activity
    W N Procopio
    Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6142, USA
    J Biol Chem 274:30196-201. 1999
    ....
  93. ncbi Activation of the orphan endothelial receptor Tie1 modifies Tie2-mediated intracellular signaling and cell survival
    Hai Tao Yuan
    Division of Molecular and Vascular Medicine, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Ave, RW663, Boston, MA 02215, USA
    FASEB J 21:3171-83. 2007
    ..The experiments also constitute a paradigm for how endothelial integrity is fine-tuned by the interplay between closely related receptors by a single growth factor...
  94. ncbi Expression of Tie-2 by human monocytes and their responses to angiopoietin-2
    Craig Murdoch
    Tumor Targeting Group, Academic Unit of Pathology, Division of Genomic Medicine, The Sir Henry Wellcome Laboratories for Medical Research, University of Sheffield Medical School, Sheffield, United Kingdom
    J Immunol 178:7405-11. 2007
    ..In sum, our data indicate that Ang-2 may recruit Tie-2(+) monocytes to tumors and sites of inflammation, modulate their release of important cytokines and stimulate them to express a proangiogenic phenotype...
  95. ncbi Evidence for heterotypic interaction between the receptor tyrosine kinases TIE-1 and TIE-2
    M B Marron
    Department of Surgery, University of Leicester, RKCSB, P O Box 65, Leicester LE2 7LX, United Kingdom
    J Biol Chem 275:39741-6. 2000
    ..The data suggest Tie-1 does not signal via ligand-induced kinase activation involving homo-oligomerization. The physical association between Tie-1 and Tie-2 is consistent with Tie-1 having a role in modulating Tie-2 signaling...
  96. ncbi Angiopoietin-mediated endothelial P-selectin translocation: cell signaling mechanisms
    Ricardo Maliba
    Montreal Heart Institute and Department of Pharmacology, Universite de Montreal, Montreal, Quebec, Canada, H1T 1C8
    J Leukoc Biol 83:352-60. 2008
    ..In addition, we demonstrate for the first time that angiopoietin-mediated endothelial P-selectin translocation is calcium-dependent and regulated through phospholipase C-gamma activation...
  97. ncbi Crystal structures of the Tie2 receptor ectodomain and the angiopoietin-2-Tie2 complex
    William A Barton
    Structural Biology Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, New York 10021, USA
    Nat Struct Mol Biol 13:524-32. 2006
    ..Analysis of the structures and structure-based mutagenesis provide insight into the mechanism of receptor activation and support the hypothesis that all angiopoietins interact with Tie2 in a structurally similar manner...
  98. ncbi Vasculogenesis in the day 6.5 to 9.5 mouse embryo
    C J Drake
    Medical University of South Carolina, Department of Cell Biology and the Cardiovascular Developmental Biology Center, Charleston, SC 29425, USA
    Blood 95:1671-9. 2000
    ..Blood. 2000;95:1671-1679)..
  99. pmc Angiogenic actions of angiopoietin-1 require endothelium-derived nitric oxide
    Saeid Babaei
    Terrence Donnelly Heart Center and Division of Cardiology, St Michael s Hospital, Toronto, Ontario, Canada
    Am J Pathol 162:1927-36. 2003
    ..In summary, our results demonstrate for the first time that endothelial-derived NO is required for Ang1-induced angiogenesis, and that the PI3-kinase signaling mediates the activation of eNOS and NO release in response to Ang1...
  100. ncbi Endothelial/pericyte interactions
    Annika Armulik
    Division of Matrix Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
    Circ Res 97:512-23. 2005
    ..We finally highlight recent important data contributing to the understanding of the role of pericytes in tumor angiogenesis, diabetic retinopathy, and hereditary lymphedema...
  101. ncbi Tie2 identifies a hematopoietic lineage of proangiogenic monocytes required for tumor vessel formation and a mesenchymal population of pericyte progenitors
    Michele De Palma
    Angiogenesis and Tumor Targeting Research Unit, San Raffaele Institute, Milano, Italy
    Cancer Cell 8:211-26. 2005
    ..Therefore, Tie2 expression characterizes three distinct cell types required for tumor neovascularization: ECs, proangiogenic cells of hematopoietic origin, and pericyte precursors of mesenchymal origin...

Research Grants31

  1. Venous Malformations (VM): A Murine Model to Identify Therapies to Target Aberran
    Elisa Boscolo; Fiscal Year: 2013
    ....
  2. Nitric Oxide in Tumor Angiogenesis, Microcirculation and Radiation Therapy
    Dai Fukumura; Fiscal Year: 2012
    ..This project will advance the basic understanding of NO-mediated vessel maturation and help develop novel strategies to improve the delivery of drugs and oxygen to tumors. ..
  3. Biology of Tie2 in sepsis
    Samir M Parikh; Fiscal Year: 2013
    ..We have assembled a team of experts in sepsis research, rodent physiology, mouse genetic models, and Tie-2 signaling to assist us. ..
  4. Role of Angiogenesis Following Stroke
    Patrick Lyden; Fiscal Year: 2006
    ..abstract_text> ..
  5. Intravascular Thrombosis in Glioblastoma
    Daniel Brat; Fiscal Year: 2005
    ..Our emerging model represents a paradigm shift in the understanding of GBM and should lead directly to more effective therapies. ..
  6. Angiopoietins in Angiogenesis
    Qin Yu; Fiscal Year: 2006
    ..abstract_text> ..
  7. TIE2-Associated Molecular Targets in Tumor Vasculature
    DANIEL KENAN; Fiscal Year: 2003
    ..Validated ligands have strong potential for development as biomarker-specific probes with applications in basic science, therapeutics, diagnostics, and imaging of early events in tumor angiogenesis. ..
  8. TIE2 RECEPTOR BASED INHIBITORS OF TUMOR ANGIOGENESIS
    P Lin; Fiscal Year: 2002
    ..This multi-faceted approach to the design and development of endothelium-specific inhibitors will allow the selection of the most effective and specific inhibitors of tumor angiogenesis. ..
  9. Vaso-occlusive Mechanisms that Induce Hypoxia and Cause Glioma Progression.
    Daniel J Brat; Fiscal Year: 2010
    ..This proposal introduces entirely novel concepts that may explain the highly aggressive properties of GBM and suggests therapeutic approaches that could potentially stabilize its progression. ..
  10. Regulation of Angiogenesis During Wound Healing
    Eric Howard; Fiscal Year: 2005
    ....
  11. Novel Small-Molecule Inhibitors of the Tie2/Angiopoietin Interactions and Signali
    Dimitar Nikolov; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  12. Structure Study of Angiopoietins and the Tie2 Receptor
    Dimitar Nikolov; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  13. Extracellular Proteinases in Ocular Neovascularization
    Arup Das; Fiscal Year: 2010
    ..Such an approach will provide a rational basis for the development of potentially powerful and effective therapeutics for ocular neovascularization. ..
  14. Tumor metastasis: Biobehavioral mechanisms
    Anil K Sood; Fiscal Year: 2009
    ....
  15. Mechanism of Myocardial Angiogenesis in Transgenic/Knockout Animals
    Nilanjana Maulik; Fiscal Year: 2010
    ..This proposal will provide and will identify important new insights into the cellular and molecular mechanisms of the cardioprotection provided by VEGF signaling through important candidate genes. ..
  16. Efficacy and toxicity of TRAIL against gliomas
    Vinay K Puduvalli; Fiscal Year: 2010
    ..The results of this study could also potentially provide a basis for clinical trials using TRAIL or analogues against gliomas and allow rational selection of agents to modulate the tumor resistance to TRAIL. ..
  17. Function of VEGF Receptor-1 on Colorectal Cancer Cells
    Lee Ellis; Fiscal Year: 2009
    ..In addition, it is possible that VEGFR-1 expression on CRC cells may serve as a "predictive factor" for anti-VEGF/receptor containing anti-neoplastic regimens. ..
  18. Therapeutic Modulation of COX-2-induced Immunosuppression in Metastatic RCC
    Brian Rini; Fiscal Year: 2008
    ..This project will have broad implications for the immunoregulation of cancer and how expression and modulation of COX-2 expression influences the immune response to cancer. [unreadable] [unreadable] [unreadable]..
  19. Regulation of Coronary Vessel Assembly and Growth
    Robert Tomanek; Fiscal Year: 2007
    ..Since cardiac development depends on timely and adequate vascularization, an understanding of coronary vasculogenesis and angiogenesis will provide an important foundation for our understanding of cardiac defects. ..
  20. Regulation of Angiogenesis via EphB4 Signaling
    JENA STEINLE; Fiscal Year: 2002
    ..These results from both mesenteric and retinal endothelial cells will greatly increase our understanding of Eph B4 receptor regulation of the various stages of angiogenesis. ..
  21. Age, VEGF, and skeletal muscle capillarization in humans
    TIMOTHY GAVIN; Fiscal Year: 2003
    ..Data obtained from these studies will provide necessary information for future R01 funding. Findings will be important as little is known concerning the effects of aging on neovascularization potential in humans. ..
  22. ANGIOGENIC THERAPY FOR INFARCTED AND ISCHEMIC HEART
    Robert Tomanek; Fiscal Year: 2003
    ..Such interventions have a number of advantages over more invasive interventions, e.g., the delivery of oxogenous growth factors or gene therapy. ..
  23. Correlative trial of fenretinide against Glioblastomas
    VINAY PUDUVALLI; Fiscal Year: 2003
    ..Such data could be relevant not only to future trials of retinoids in gliomas but also for ongoing trials of fenretinide in other malignancies. ..
  24. CYTOKINE REGULATION OF EARLY EVENTS IN BLOOD VESSEL FORM
    Christopher Drake; Fiscal Year: 2006
    ..abstract_text> ..
  25. Regulation of Microvascular Development in BPD
    William Maniscalco; Fiscal Year: 2006
    ..New data from this proposal will be essential for developing novel therapies for BPD. ..
  26. Mechanisms of myometrial healing and regeneration
    Catalin Buhimschi; Fiscal Year: 2006
    ....
  27. Neurorestorative Therapy of Stroke with Statins
    Jieli Chen; Fiscal Year: 2007
    ..This study provides a new and highly effective way to treat stroke and may permit translation our finding of restorative therapeutic benefit of statin in experimental stroke to the patient. ..
  28. Functional role of Angiopoietin-2 in diabetic heart
    Jian xiong Chen; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  29. ESTROGEN EFFECT ON COLLATERAL GROWTH AND FUNCTION
    Kathryn Lamping; Fiscal Year: 2001
    ....