receptor protein tyrosine kinases

Summary

Summary: A class of cellular receptors that have an intrinsic PROTEIN-TYROSINE KINASE activity.

Top Publications

  1. ncbi Defects in the kidney and enteric nervous system of mice lacking the tyrosine kinase receptor Ret
    A Schuchardt
    Department of Genetics, College of Physicians and Surgeons, Columbia University, New York, New York 10032
    Nature 367:380-3. 1994
  2. ncbi An evolutionarily conserved function of the Drosophila insulin receptor and insulin-like peptides in growth control
    W Brogiolo
    Zoologisches Institut, Universitat Zurich, Winterthurerstrasse 190, CH 8057, Zurich, Switzerland
    Curr Biol 11:213-21. 2001
  3. ncbi Oncogenic kinase signalling
    P Blume-Jensen
    The Salk Institute, Molecular and Cell Biology Laboratory, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
    Nature 411:355-65. 2001
  4. ncbi Receptor specificity of the fibroblast growth factor family
    D M Ornitz
    Department of Molecular Biology and Pharmacology, Washington University Medical School, St Louis, Missouri 63110, USA
    J Biol Chem 271:15292-7. 1996
  5. ncbi A nutrient sensor mechanism controls Drosophila growth
    Julien Colombani
    Institute for Signaling, Developmental Biology and Cancer Research, UMR6543 CNRS Parc Valrose, 06108, Cedex 2, Nice, France
    Cell 114:739-49. 2003
  6. ncbi Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis
    P C Maisonpierre
    Regeneron Pharmaceuticals Inc, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA
    Science 277:55-60. 1997
  7. ncbi Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice
    F Shalaby
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    Nature 376:62-6. 1995
  8. pmc Targeted disruption of fibroblast growth factor (FGF) receptor 2 suggests a role for FGF signaling in pregastrulation mammalian development
    E Arman
    Department of Molecular Genetics, The Weizmann Institute of Science, Rehovot, Israel 76100, USA
    Proc Natl Acad Sci U S A 95:5082-7. 1998
  9. ncbi Essential role for the c-met receptor in the migration of myogenic precursor cells into the limb bud
    F Bladt
    Max Delbruck Centrum fur Molekulare Medizin, Berlin, Germany
    Nature 376:768-71. 1995
  10. ncbi Mammalian Ryk is a Wnt coreceptor required for stimulation of neurite outgrowth
    Wange Lu
    California Institute of Technology, Division of Biology, Pasadena, CA 91125, USA
    Cell 119:97-108. 2004

Detail Information

Publications335 found, 100 shown here

  1. ncbi Defects in the kidney and enteric nervous system of mice lacking the tyrosine kinase receptor Ret
    A Schuchardt
    Department of Genetics, College of Physicians and Surgeons, Columbia University, New York, New York 10032
    Nature 367:380-3. 1994
    ..Ret is thus an essential component of a signalling pathway required for renal organogenesis and enteric neurogenesis...
  2. ncbi An evolutionarily conserved function of the Drosophila insulin receptor and insulin-like peptides in growth control
    W Brogiolo
    Zoologisches Institut, Universitat Zurich, Winterthurerstrasse 190, CH 8057, Zurich, Switzerland
    Curr Biol 11:213-21. 2001
    ....
  3. ncbi Oncogenic kinase signalling
    P Blume-Jensen
    The Salk Institute, Molecular and Cell Biology Laboratory, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
    Nature 411:355-65. 2001
    ....
  4. ncbi Receptor specificity of the fibroblast growth factor family
    D M Ornitz
    Department of Molecular Biology and Pharmacology, Washington University Medical School, St Louis, Missouri 63110, USA
    J Biol Chem 271:15292-7. 1996
    ..These data should serve as a biochemical foundation for determining developmental, physiological, and pathophysiological processes that involve FGF signaling pathways...
  5. ncbi A nutrient sensor mechanism controls Drosophila growth
    Julien Colombani
    Institute for Signaling, Developmental Biology and Cancer Research, UMR6543 CNRS Parc Valrose, 06108, Cedex 2, Nice, France
    Cell 114:739-49. 2003
    ..Our results demonstrate that the fat body functions as a nutrient sensor that restricts global growth through a humoral mechanism...
  6. ncbi Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis
    P C Maisonpierre
    Regeneron Pharmaceuticals Inc, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA
    Science 277:55-60. 1997
    ..Natural antagonists for vertebrate receptor tyrosine kinases are atypical; thus, the discovery of a negative regulator acting on Tie2 emphasizes the need for exquisite regulation of this angiogenic receptor system...
  7. ncbi Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice
    F Shalaby
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    Nature 376:62-6. 1995
    ..These results indicate that Flk-1 is essential for yolk-sac blood-island formation and vasculogenesis in the mouse embryo...
  8. pmc Targeted disruption of fibroblast growth factor (FGF) receptor 2 suggests a role for FGF signaling in pregastrulation mammalian development
    E Arman
    Department of Molecular Genetics, The Weizmann Institute of Science, Rehovot, Israel 76100, USA
    Proc Natl Acad Sci U S A 95:5082-7. 1998
    ..The role of early FGF signaling in pregastrulation development as a possible adaptation to mammalian (amniote) embryogenesis is discussed...
  9. ncbi Essential role for the c-met receptor in the migration of myogenic precursor cells into the limb bud
    F Bladt
    Max Delbruck Centrum fur Molekulare Medizin, Berlin, Germany
    Nature 376:768-71. 1995
    ..We have therefore identified a paracrine signalling system that regulates migration of myogenic precursor cells...
  10. ncbi Mammalian Ryk is a Wnt coreceptor required for stimulation of neurite outgrowth
    Wange Lu
    California Institute of Technology, Division of Biology, Pasadena, CA 91125, USA
    Cell 119:97-108. 2004
    ..Thus, Ryk appears to play a crucial role in Wnt-mediated signaling...
  11. ncbi Mutation of the receptor tyrosine kinase gene Mertk in the retinal dystrophic RCS rat
    P M D'Cruz
    Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305 5120, USA
    Hum Mol Genet 9:645-51. 2000
    ..Our results provide genetic evidence for an essential role of a receptor tyrosine kinase in a specialized form of phagocytosis and suggest a molecular model for ingestion of outer segments by RPE cells...
  12. ncbi Renal agenesis and the absence of enteric neurons in mice lacking GDNF
    M P Sanchez
    Department of Molecular Oncology, Bristol Myers Squibb Pharmaceutical Research Institute, Princeton, New Jersey 08543, USA
    Nature 382:70-3. 1996
    ..However, ablation of the GDNF gene does not affect the differentiation and survival of dopaminergic neurons, at least during embryonic development...
  13. pmc Lrp4 is a receptor for Agrin and forms a complex with MuSK
    Natalie Kim
    Molecular Neurobiology Program, Skirball Institute of Biomolecular Medicine, Helen and Martin Kimmel Center for Biology and Medicine, NYU Medical School, New York, NY 10016, USA
    Cell 135:334-42. 2008
    ..Here, we report that Lrp4, a member of the LDLR family, is a receptor for Agrin, forms a complex with MuSK, and mediates MuSK activation by Agrin...
  14. pmc LRP4 serves as a coreceptor of agrin
    Bin Zhang
    Program of Developmental Neurobiology, Institute of Molecular Medicine and Genetics, Department of Neurology, Medical College of Georgia, Augusta, GA 30912, USA
    Neuron 60:285-97. 2008
    ..These observations indicate that LRP4 is a coreceptor of agrin that is necessary for MuSK signaling and AChR clustering and identify a potential target protein whose mutation and/or autoimmunization may cause muscular dystrophies...
  15. ncbi The discoidin domain receptor tyrosine kinases are activated by collagen
    W Vogel
    Programme in Molecular Biology and Cancer, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    Mol Cell 1:13-23. 1997
    ..These results suggest that the discoidin-related DDR tyrosine kinases are novel collagen receptors with the potential to control cellular responses to the extracellular matrix...
  16. ncbi Mutations in the RET proto-oncogene are associated with MEN 2A and FMTC
    H Donis-Keller
    Division of Human Molecular Genetics, Washington University School of Medicine, St Louis, MO 63110
    Hum Mol Genet 2:851-6. 1993
    ..However, its apparent involvement in the development of these inherited forms of neoplasia as well as in papillary thyroid carcinoma suggest an important developmental or cell regulatory role for the protein...
  17. ncbi A mutation in the RET proto-oncogene associated with multiple endocrine neoplasia type 2B and sporadic medullary thyroid carcinoma
    R M Hofstra
    Department of Medical Genetics, University of Groningen, The Netherlands
    Nature 367:375-6. 1994
    ..The same mutation was found in six out of 18 sporadic tumours...
  18. ncbi Coactivation of receptor tyrosine kinases affects the response of tumor cells to targeted therapies
    Jayne M Stommel
    Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, MA 02115, USA
    Science 318:287-90. 2007
    ..Thus, effective GBM therapy may require combined regimens targeting multiple RTKs...
  19. ncbi PTK7/CCK-4 is a novel regulator of planar cell polarity in vertebrates
    Xiaowei Lu
    Department of Biological Sciences, Howard Hughes Medical Institute, Stanford, California 94305, USA
    Nature 430:93-8. 2004
    ..These results identify PTK7 as a novel regulator of PCP in vertebrates...
  20. pmc Isolated lymphatic endothelial cells transduce growth, survival and migratory signals via the VEGF-C/D receptor VEGFR-3
    T Makinen
    Molecular Cancer Biology Laboratory and Ludwig Institute for Cancer Research, and Helsinki University Hospital, Biomedicum Helsinki, University of Helsinki, FIN 00014 Helsinki, Finland
    EMBO J 20:4762-73. 2001
    ..The culture of isolated lymphatic endothelial cells should now allow further studies of the molecular properties of these cells...
  21. pmc A model for gene therapy of human hereditary lymphedema
    M J Karkkainen
    Molecular Cancer Biology Laboratory and Ludwig Institute for Cancer Research, Haartman Institute and Helsinki University Hospital, Biomedicum Helsinki, University of Helsinki, P O B 63 Haartmaninkatu 8, 00014 Helsinki, Finland
    Proc Natl Acad Sci U S A 98:12677-82. 2001
    ..Our results suggest that growth factor gene therapy is applicable to human lymphedema and provide a paradigm for other diseases associated with mutant receptors...
  22. ncbi The anticoagulation factor protein S and its relative, Gas6, are ligands for the Tyro 3/Axl family of receptor tyrosine kinases
    T N Stitt
    Regeneron Pharmaceuticals, Incorporated, Tarrytown, New York 10591
    Cell 80:661-70. 1995
    ....
  23. ncbi Protein tyrosine kinase structure and function
    S R Hubbard
    Skirball Institute of Biomolecular Medicine and Department of Pharmacology, New York University School of Medicine, New York, New York 10016, USA
    Annu Rev Biochem 69:373-98. 2000
    ..This review will highlight the important results that have emerged from these structural studies...
  24. ncbi The PDGF/VEGF receptor controls blood cell survival in Drosophila
    Katja Brückner
    Department of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Dev Cell 7:73-84. 2004
    ..This function of PVR shows striking conservation with mammalian hematopoiesis and establishes Drosophila as a model to study hematopoietic cell survival in development and disease...
  25. ncbi Craniosynostosis: genes and mechanisms
    A O Wilkie
    Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, UK
    Hum Mol Genet 6:1647-56. 1997
    ....
  26. ncbi Patterning of muscle acetylcholine receptor gene expression in the absence of motor innervation
    X Yang
    Molecular Neurobiology Program, Skirball Institute, New York University Medical School, New York, NY 10011, USA
    Neuron 30:399-410. 2001
    ..Our results demonstrate that AChR expression is patterned in the absence of innervation, raising the possibility that similarly prepatterned muscle-derived cues restrict axon growth and initiate synapse formation...
  27. ncbi Germ-line mutations of the RET proto-oncogene in multiple endocrine neoplasia type 2A
    L M Mulligan
    Department of Pathology, University of Cambridge, UK
    Nature 363:458-60. 1993
    ..Further, 19 of these 20 mutations affect the same conserved cysteine residue at the boundary of the RET extracellular and transmembrane domains...
  28. ncbi Tie2 receptor ligands, angiopoietin-1 and angiopoietin-2, modulate VEGF-induced postnatal neovascularization
    T Asahara
    Department of Medicine Cardiology, St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, Mass 02135, USA
    Circ Res 83:233-40. 1998
    ..Moreover, these findings provide in vivo evidence that Ang1 promotes vascular network maturation, whereas Ang2 works to initiate neovascularization...
  29. ncbi Suppression of tumor lymphangiogenesis and lymph node metastasis by blocking vascular endothelial growth factor receptor 3 signaling
    Yulong He
    Molecular Cancer Biology Laboratory and Ludwig Institute for Cancer Research, Haartman Institute and Helsinki University Central Hospital, Biomedicum Helsinki, University of Helsinki, Finland
    J Natl Cancer Inst 94:819-25. 2002
    ..We sought to determine whether inhibiting VEGFR-3 signaling, and thus tumor lymphangiogenesis, would inhibit tumor metastasis...
  30. ncbi Gas6 and protein S. Vitamin K-dependent ligands for the Axl receptor tyrosine kinase subfamily
    Sassan Hafizi
    Lund University, Department of Laboratory Medicine, Section for Clinical Chemistry, Wallenberg Laboratory, University Hospital Malmo, Sweden
    FEBS J 273:5231-44. 2006
    ..Further knowledge of this exquisite ligand-receptor system and the circumstances of its activation should provide the basis for development of novel therapies for the above diseases...
  31. ncbi A requirement for Flk1 in primitive and definitive hematopoiesis and vasculogenesis
    F Shalaby
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    Cell 89:981-90. 1997
    ....
  32. ncbi Signalling and functional diversity within the Axl subfamily of receptor tyrosine kinases
    Sassan Hafizi
    Department of Clinical Chemistry, Lund University, Wallenberg Laboratory, University Hospital Malmo, SE 205 02 Malmo, Sweden
    Cytokine Growth Factor Rev 17:295-304. 2006
    ..In this way, we hope to gain a greater understanding of the mechanisms that set each of them apart, and that relay their associated functions...
  33. ncbi Cardiovascular failure in mouse embryos deficient in VEGF receptor-3
    D J Dumont
    Ontario Cancer Institute and Amgen Institute, Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada M5G 2C1
    Science 282:946-9. 1998
    ..5. Thus, VEGFR-3 has an essential role in the development of the embryonic cardiovascular system before the emergence of the lymphatic vessels...
  34. ncbi Inhibition of lymphangiogenesis with resulting lymphedema in transgenic mice expressing soluble VEGF receptor-3
    T Makinen
    Molecular Cancer Biology Laboratory and Ludwig Institute for Cancer Research, Haartman Institute, University of Helsinki, Helsinki, Finland
    Nat Med 7:199-205. 2001
    ....
  35. ncbi The receptor tyrosine kinase MuSK is required for neuromuscular junction formation in vivo
    T M DeChiara
    Regeneron Pharmaceuticals, Inc, Tarrytown, New York 10591, USA
    Cell 85:501-12. 1996
    ....
  36. pmc Purified Wnt5a protein activates or inhibits beta-catenin-TCF signaling depending on receptor context
    Amanda J Mikels
    Department of Developmental Biology, Stanford University School of Medicine, Stanford, California, United States of America
    PLoS Biol 4:e115. 2006
    ..In this model, signaling by different Wnt family members is not intrinsically regulated by the Wnt proteins themselves but by receptor availability...
  37. ncbi Cloning and mRNA expression analysis of a novel human protooncogene, c-mer
    D K Graham
    Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill 27599 7295
    Cell Growth Differ 5:647-57. 1994
    ....
  38. ncbi Sensing extracellular matrix: an update on discoidin domain receptor function
    Wolfgang F Vogel
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario Canada, M5S 1A8
    Cell Signal 18:1108-16. 2006
    ..By highlighting current questions about these unusual collagen receptors, we hope to attract new research on DDRs from a variety of different fields...
  39. ncbi AXL is a potential target for therapeutic intervention in breast cancer progression
    Yi Xiang Zhang
    Max Planck Institute of Biochemistry, Martinsried, Germany
    Cancer Res 68:1905-15. 2008
    ....
  40. pmc Focal adhesion kinase signaling promotes phagocytosis of integrin-bound photoreceptors
    Silvia C Finnemann
    Dyson Vision Research Institute, Department of Ophthalmology, Weill Medical College of Cornell University, New York, NY 10021, USA
    EMBO J 22:4143-54. 2003
    ..In contrast, inhibition of FAK signaling diminishes MerTK phosphorylation. These results demonstrate that FAK provides an essential link between binding and engulfment mechanisms of integrin-mediated phagocytosis...
  41. pmc axl, a transforming gene isolated from primary human myeloid leukemia cells, encodes a novel receptor tyrosine kinase
    J P O'Bryan
    Curriculum in Genetics, Lineberger Cancer Research Center, University of North Carolina, Chapel Hill 27599
    Mol Cell Biol 11:5016-31. 1991
    ....
  42. ncbi Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium
    G H Fong
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    Nature 376:66-70. 1995
    ..We suggest that the Flt-1 signalling pathway may regulate normal endothelial cell-cell or cell-matrix interactions during vascular development...
  43. ncbi Distinct monoubiquitin signals in receptor endocytosis
    Kaisa Haglund
    Institute of Biochemistry II, Goethe University Medical School, Theodor Stern Kai 7, D 60590 Frankfurt, Germany
    Trends Biochem Sci 28:598-603. 2003
    ....
  44. ncbi Expression of the receptor tyrosine kinase Axl promotes ocular melanoma cell survival
    Paul R Van Ginkel
    Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, Madison, Wisconsin 53792, USA
    Cancer Res 64:128-34. 2004
    ..These data show that the Axl pathway mediates increased survival of uveal melanoma cells, potentially advantageous during cancer dormancy, and that Axl may function in part through regulation of Cyr61...
  45. pmc MuSK controls where motor axons grow and form synapses
    Natalie Kim
    Molecular Neurobiology Program, The Helen L and Martin S Kimmel Center for Biology and Medicine at the Skirball Institute of Biomolecular Medicine, New York University Medical School, New York, NY 10016, USA
    Nat Neurosci 11:19-27. 2008
    ....
  46. ncbi Multiple roles for the receptor tyrosine kinase axl in tumor formation
    Sacha J Holland
    Rigel, Inc, South San Francisco, California and University of Michigan School of Dentistry, Ann Arbor, MI, USA
    Cancer Res 65:9294-303. 2005
    ..Disruption of Axl signaling using a small-molecule inhibitor will hence simultaneously affect both the tumor and stromal cell compartments and thus represents a unique approach for cancer therapeutic development...
  47. ncbi PTK7 recruits dsh to regulate neural crest migration
    Iryna Shnitsar
    Department of Developmental Biochemistry, Center for Molecular Physiology of the Brain CMPB 37077 Goettingen, Germany
    Development 135:4015-24. 2008
    ..Thus, PTK7 regulates neural crest migration by recruiting dsh, providing molecular evidence of how PTK7 intersects with the PCP signaling pathway to regulate vertebrate cell movements...
  48. ncbi Molecular analysis of collagen binding by the human discoidin domain receptors, DDR1 and DDR2. Identification of collagen binding sites in DDR2
    Birgit Leitinger
    Sackler Institute for Muscular Skeletal Research, Department of Medicine, University College London, 5 University St, London WC1E 6JJ, United Kingdom
    J Biol Chem 278:16761-9. 2003
    ..In addition, the same loops were required for collagen-dependent receptor activation. It is concluded that the loop region opposite to the polypeptide chain termini of the DDR2 discoidin domain constitutes the collagen recognition site...
  49. pmc The features of myasthenia gravis with autoantibodies to MuSK
    D Lavrnic
    The Institute of Neurology, Clinical Centre of Serbia, 11000 Belgrade, 6 Dr Subotica Street, Serbia and Montenegro
    J Neurol Neurosurg Psychiatry 76:1099-102. 2005
    ..To determine if myasthenia gravis (MG) with antibodies to MuSK is a distinct subgroup of seronegative MG...
  50. pmc The collagen receptor DDR2 regulates proliferation and its elimination leads to dwarfism
    J P Labrador
    European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    EMBO Rep 2:446-52. 2001
    ..Together our results suggest that DDR2 acts as an extracellular matrix sensor to modulate cell proliferation...
  51. ncbi Axl receptor tyrosine kinase expression in human lung cancer cell lines correlates with cellular adhesion
    A Wimmel
    , , , Baldinger Str, D-35033 Marburg, Germany
    Eur J Cancer 37:2264-74. 2001
    ..We conclude from these data that loss of Axl expression is a feature of SCLC tumour cells. Axl expression appears to be a consequence of cellular adhesion and possibly influences differentiation in human lung cancers...
  52. pmc The Caenorhabditis elegans Ror RTK CAM-1 inhibits EGL-20/Wnt signaling in cell migration
    Wayne C Forrester
    Department of Biology, Indiana University, Bloomington, Indiana 47405, USA
    Genetics 168:1951-62. 2004
    ..The reversal in the migration of the left Q neuroblast and its descendants resulted from a failure to express mab-5, an egl-20 mutant phenotype. Our data suggest that CAM-1 negatively regulates EGL-20...
  53. pmc Crystallographic insight into collagen recognition by discoidin domain receptor 2
    Federico Carafoli
    Department of Life Sciences, Imperial College London, London SW7 2AZ, UK
    Structure 17:1573-81. 2009
    ..A comparison of the GVMGFO-binding sites of DDR2 and SPARC reveals a striking case of convergent evolution in collagen recognition...
  54. pmc Role of discoidin domain receptors 1 and 2 in human smooth muscle cell-mediated collagen remodeling: potential implications in atherosclerosis and lymphangioleiomyomatosis
    Nicola Ferri
    Department of Pathology, University of Washington School of Medicine, Seattle, Washington, USA
    Am J Pathol 164:1575-85. 2004
    ..Taken together, these data provide evidence for the potential roles of DDR1 and DDR2 in the regulation of collagen turnover mediated by SMCs in obstructive diseases of blood vessels and the lung...
  55. pmc Inhibition of synapse assembly in mammalian muscle in vivo by RNA interference
    Xian Chu Kong
    Biozentrum, University of Basel, Basel, Switzerland
    EMBO Rep 5:183-8. 2004
    ..Moreover, they show that MuSK is also required for the maintenance of the NMJ, offering a mechanistic explanation for the myasthenia gravis caused by auto-antibodies to MuSK...
  56. ncbi Revascularization of ischemic tissues by PlGF treatment, and inhibition of tumor angiogenesis, arthritis and atherosclerosis by anti-Flt1
    Aernout Luttun
    Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, University of Leuven, Leuven, Belgium
    Nat Med 8:831-40. 2002
    ..Thus, PlGF and Flt1 constitute potential candidates for therapeutic modulation of angiogenesis and inflammation...
  57. ncbi Signalling pathways initiated by receptor protein tyrosine kinases in Drosophila
    N Perrimon
    Howard Hughes Medical Institute, Department of Genetics, Harvard Medical School, Boston, MA 02115
    Curr Opin Cell Biol 6:260-6. 1994
    The isolation and characterization of Drosophila mutations in receptor protein tyrosine kinases (RPTKs) have allowed a detailed analysis of the cellular processes regulated by these proteins...
  58. ncbi Overexpression of the cell adhesion molecules DDR1, Claudin 3, and Ep-CAM in metaplastic ovarian epithelium and ovarian cancer
    Viola A Heinzelmann-Schwarz
    Cancer Research Program, Garvan Institute of Medical Research, Darlinghurst, Australia
    Clin Cancer Res 10:4427-36. 2004
    ..The aims of this study were to integrate the results from 14 transcript profiling studies of EOC to identify novel biomarkers and to examine their expression in early and late stages of the disease...
  59. ncbi The synaptic muscle-specific kinase (MuSK) complex: new partners, new functions
    Laure Strochlic
    Biologie Cellulaire des Membranes, Institut Jacques Monod, Paris, France
    Bioessays 27:1129-35. 2005
    ..This minireview will focus on the multiple MuSK effectors so far identified that place MuSK at the center of a multifunctional signaling complex involved in the organization of the NMJ and associated disorders...
  60. ncbi Phagocytosis and clearance of apoptotic cells is mediated by MER
    R S Scott
    UNC Neuroscience Center, USA
    Nature 411:207-11. 2001
    ..Thus, the Mer receptor tyrosine kinase seems to be critical for the engulfment and efficient clearance of apoptotic cells. This has implications for inflammation and autoimmune diseases such as systemic lupus erythematosus...
  61. ncbi Macrophages and dendritic cells use different Axl/Mertk/Tyro3 receptors in clearance of apoptotic cells
    Heather M Seitz
    Department of Microbiology and Immunology, University of North Carolina Chapel Hill, Chapel Hill, NC 27599, USA
    J Immunol 178:5635-42. 2007
    ....
  62. ncbi Impaired recruitment of bone-marrow-derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth
    D Lyden
    Department of Pediatrics, Memorial Sloan-Kettering Cancer Center, New York, New York, USA
    Nat Med 7:1194-201. 2001
    ..These data demonstrate that recruitment of VEGF-responsive BM-derived precursors is necessary and sufficient for tumor angiogenesis and suggest new clinical strategies to block tumor growth...
  63. ncbi VEGF165 mediates formation of complexes containing VEGFR-2 and neuropilin-1 that enhance VEGF165-receptor binding
    Shay Soker
    Department of Urology, Children s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Cell Biochem 85:357-68. 2002
    ..These complexes are formed on the surface of EC and in a juxtacrine manner via association of tumor cell NRP1 and EC KDR...
  64. ncbi ERBB receptors and cancer: the complexity of targeted inhibitors
    Nancy E Hynes
    Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH 4058 Basel, Switzerland
    Nat Rev Cancer 5:341-54. 2005
    ..We will discuss the significance of these receptors as clinical targets, in particular the molecular mechanisms underlying response...
  65. ncbi An orphan receptor tyrosine kinase family whose members serve as nonintegrin collagen receptors
    A Shrivastava
    Begeneron Pharmaceuticals, Inc, Tarrytown, New York 10591, USA
    Mol Cell 1:25-34. 1997
    ....
  66. ncbi A mutant Drosophila insulin receptor homolog that extends life-span and impairs neuroendocrine function
    M Tatar
    Brown University, Providence, RI 02912, USA, University of Massachusetts, Amherst, MA 01003, USA
    Science 292:107-10. 2001
    ....
  67. ncbi Mammalian collagen receptors
    Birgit Leitinger
    National Heart and Lung Institute, Imperial College London, London SW7 2AZ, UK
    Matrix Biol 26:146-55. 2007
    ..In this review, we discuss the structure and function of these receptors, focussing on the principles involved in collagen recognition...
  68. pmc Biologic significance of angiopoietin-2 expression in human hepatocellular carcinoma
    S Tanaka
    Department of Surgery, Medical Institute of Bioregulation, Kyushu University, Beppu 874 0838, Japan
    J Clin Invest 103:341-5. 1999
    ..These results suggest a role for Ang2 in the neovascularization of HCC. This enhanced gene expression may contribute to the clinical hypervascular phenotype, as well as tumor formation and progression...
  69. ncbi Colon carcinoma kinase-4 defines a new subclass of the receptor tyrosine kinase family
    K Mossie
    SUGEN, Inc, Redwood City, California 94063, USA
    Oncogene 11:2179-84. 1995
    ....
  70. pmc Vascular endothelial growth factor B (VEGF-B) binds to VEGF receptor-1 and regulates plasminogen activator activity in endothelial cells
    B Olofsson
    Ludwig Institute for Cancer Research, Stockholm Branch, Box 240, S 171 77 Stockholm, Sweden
    Proc Natl Acad Sci U S A 95:11709-14. 1998
    ....
  71. ncbi Molecular mechanisms of lymphangiogenesis in health and disease
    Kari Alitalo
    Molecular Cancer Biology Laboratory, Biomedicum Helsinki, Haartman Institute and Helsinki University Central Hospital, POB 63 Haartmaninkatu 8, 00014 University of Helsinki, Finland
    Cancer Cell 1:219-27. 2002
    ..In addition, these studies have opened novel diagnostic and therapeutic avenues for the treatment of lymphedema and metastasis. This overview highlights the recent insights and developments in the field of lymphatic vascular research...
  72. ncbi Deregulated inflammatory response in mice lacking the STK/RON receptor tyrosine kinase
    P H Correll
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    Genes Funct 1:69-83. 1997
    ..These data suggest that the STK receptor suppresses NO production, therefore ameliorating the potentially tissue-damaging effects of a cell-mediated immune response, through negative regulation of the IFN-gamma signalling pathway...
  73. ncbi Coordinated induction of VEGF receptors in mesenchymal cell types during rat hepatic wound healing
    V Ankoma-Sey
    UCSF Liver Center and Department of Medicine, University of California, San Francisco, USA
    Oncogene 17:115-21. 1998
    ..These findings suggest that the cellular targets of VEGF in liver may not be confined to sinusoidal endothelial cells, and that VEGF responses reflect combined effects on both hepatic stellate cells and sinusoidal endothelium...
  74. ncbi The GDNF family ligands and receptors - implications for neural development
    R H Baloh
    Departments of Pathology and Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Curr Opin Neurobiol 10:103-10. 2000
    ..The results of such analyses reveal numerous similarities and potential overlaps in the way the GDNF and the nerve growth factor (NGF) families regulate development of the peripheral nervous system...
  75. ncbi Receptor tyrosine kinases expressed in metastatic colon cancer
    R J Craven
    Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill School of Medicine 27599
    Int J Cancer 60:791-7. 1995
    ..This indicates that over-expression and possibly a differential processing event of tyrosine kinase receptors may be involved in colon cancer, and that they are potential markers for the progression of this disease...
  76. ncbi Generation of murine dendritic cells from flt3-ligand-supplemented bone marrow cultures
    K Brasel
    Departments of Immunobiology and Discovery Research, Immunex Corporation, Seattle, WA 98101, USA
    Blood 96:3029-39. 2000
    ..Stem cell factor, which exhibits some of the same bioactivities as FL, was unable to replace FL to promote DC development in vitro. This culture system will facilitate detailed analysis of murine DC development...
  77. pmc Biological effects of c-Mer receptor tyrosine kinase in hematopoietic cells depend on the Grb2 binding site in the receptor and activation of NF-kappaB
    M M Georgescu
    Laboratory of Molecular Oncology, The Rockefeller University, New York, New York 10021, USA
    Mol Cell Biol 19:1171-81. 1999
    ..Consistent with this notion, apoptosis induced by IL-3 withdrawal was strongly prevented by CDMer but not by the F867 mutant receptor...
  78. ncbi A C. elegans Ror receptor tyrosine kinase regulates cell motility and asymmetric cell division
    W C Forrester
    Department of Molecular and Cell Biology, University of California, Berkeley 94720, USA
    Nature 400:881-5. 1999
    ..Our results raise the possibility that Ror kinases regulate cell motility and asymmetric cell division in organisms as diverse as nematodes and mammals...
  79. pmc Inhibition of vascular endothelial cell growth factor activity by an endogenously encoded soluble receptor
    R L Kendall
    Department of Biochemistry, Merck Research Laboratories, Rahway, NJ 07065
    Proc Natl Acad Sci U S A 90:10705-9. 1993
    ....
  80. ncbi A novel family of cell surface receptors with tyrosine kinase-like domain
    P Masiakowski
    Regeneron Pharmaceuticals, Tarrytown, New York 10591 6707
    J Biol Chem 267:26181-90. 1992
    ..Based on these data, Ror1 and Ror2 appear to define a new developmentally regulated family of cell surface receptors for unidentified ligands...
  81. pmc Fgfr2 is required for limb outgrowth and lung-branching morphogenesis
    E Arman
    Department of Molecular Genetics, The Weizmann Institute of Science, Rehovot 76100, Israel
    Proc Natl Acad Sci U S A 96:11895-9. 1999
    ..Possible epithelial-mesenchymal interactions between the splicing alternatives of Fgfr2 and their specific ligands will be discussed...
  82. ncbi Expression of vascular endothelial growth factor receptors 1, 2 and 3 in placentas from normal and complicated pregnancies
    S Helske
    Department of Obstetrics and Gynaecology, Helsinki University Central Hospital, PL 140, 00290 Helsinki, Finland
    Mol Hum Reprod 7:205-10. 2001
    ..These results suggest that low maternal serum PlGF and increased placental expression of its receptor VEGFR-1 are associated with pre-eclampsia and FGR...
  83. ncbi A novel point mutation in the tyrosine kinase domain of the RET proto-oncogene in sporadic medullary thyroid carcinoma and in a family with FMTC
    C Eng
    Department of Pathology, University of Cambridge, UK
    Oncogene 10:509-13. 1995
    ..The same mutation was also detected in sporadic MTC but not in corresponding constitutional DNA, confirming that it is likely to be of pathological significance rather than a rare polymorphism...
  84. ncbi Vasculogenesis and angiogenesis as mechanisms of vascular network formation, growth and remodeling
    S Patan
    Division of Cardiology, Albert Einstein College of Medicine, Yeshiva University, Bronx, New York 10461, USA
    J Neurooncol 50:1-15. 2000
    ..The cellular mechanisms and the molecular regulation of angiogenesis in the pathological state are summarized and the differences of physiological and pathological angiogenesis elaborated...
  85. ncbi RET alternate splicing influences the interaction of activated RET with the SH2 and PTB domains of Shc, and the SH2 domain of Grb2
    M J Lorenzo
    CRC Human Cancer Genetics Research Group, University of Cambridge, Department of Pathology, Cambridge, UK
    Oncogene 14:763-71. 1997
    ..In addition, a splice isoform-specific HSCR missense mutation, which does not inactivate the RET kinase activity, decreases the strength of the PTB domain interaction and the level of RET-dependent Shc phosphorylation...
  86. ncbi Crystal structure of the kinase domain of human vascular endothelial growth factor receptor 2: a key enzyme in angiogenesis
    M A McTigue
    Agouron Pharmaceuticals, 3565 General Atomics Court, San Diego, CA 92121, USA
    Structure 7:319-30. 1999
    ..VEGFRs are receptor tyrosine kinases that, like the platelet-derived growth factor receptors (PDGFRs), contain a large insert within the kinase domain...
  87. pmc CLAVATA1 dominant-negative alleles reveal functional overlap between multiple receptor kinases that regulate meristem and organ development
    Anne Dievart
    Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor 48109 1048, USA
    Plant Cell 15:1198-211. 2003
    ..We propose the presence of multiple receptors that regulate meristem development in a functionally related manner whose interactions are driven by the extracellular domains and whose activation requires the kinase domain...
  88. ncbi Structural basis for FGF receptor dimerization and activation
    A N Plotnikov
    Department of Pharmacology, New York University School of Medicine, New York 10016, USA
    Cell 98:641-50. 1999
    ..A general model for FGF- and heparin-induced FGFR dimerization is inferred from the crystal structure, unifying a wealth of biochemical data...
  89. ncbi Development of the neuromuscular junction
    Veit Witzemann
    Max Planck Institut fur medizinische Forschung, Jahnstrasse 29, 69120 Heidelberg, Germany
    Cell Tissue Res 326:263-71. 2006
    ....
  90. pmc Expression of axl in lung adenocarcinoma and correlation with tumor progression
    Yi Shing Shieh
    School of Dentistry, National Defense Medical Center, Taipei, Taiwan, ROC
    Neoplasia 7:1058-64. 2005
    ..0001) and the patient's clinical stage (P < .0001). Our results demonstrate that Axl protein kinase seems to play an important role in the invasion and progression of lung cancer...
  91. ncbi Fibroblast growth factor receptor 2 (FGFR2)-mediated reciprocal regulation loop between FGF8 and FGF10 is essential for limb induction
    X Xu
    Laboratory of Biochemistry and Metabolism, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Development 125:753-65. 1998
    ....
  92. ncbi The selective tyrosine kinase inhibitor STI571 inhibits small cell lung cancer growth
    G W Krystal
    Department of Medicine, Virginia Commonwealth University, McGuire Veterans Affairs Medical Center, Richmond 23249, USA
    Clin Cancer Res 6:3319-26. 2000
    ....
  93. pmc Flk-2 is a marker in hematopoietic stem cell differentiation: a simple method to isolate long-term stem cells
    J L Christensen
    Departments of Pathology and Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305 5324, USA
    Proc Natl Acad Sci U S A 98:14541-6. 2001
    ..Fetal liver HSCs are contained within Flk-2(-) and Flk-2(+) KTLS cells...
  94. ncbi Mertk triggers uptake of photoreceptor outer segments during phagocytosis by cultured retinal pigment epithelial cells
    Wei Feng
    Department of Genetics, Stanford University School of Medicine, Stanford, California 94305 5120, USA
    J Biol Chem 277:17016-22. 2002
    ..We conclude that Mertk likely functions directly in the RPE phagocytic process as a signaling molecule triggering outer segment ingestion...
  95. ncbi Expression of neurturin, GDNF, and GDNF family-receptor mRNA in the developing and mature mouse
    J P Golden
    Department of Neurology, Washington University School of Medicine, St Louis, Missouri, 63110, USA
    Exp Neurol 158:504-28. 1999
    ..In the mature animal, receptor expression was more limited than in the embryo. In the adult mouse, NRTN was most prominently expressed in the gut, prostate testicle, and oviduct; GDNF was most prominently expressed in the ovary...
  96. ncbi Point mutation within the tyrosine kinase domain of the RET proto-oncogene in multiple endocrine neoplasia type 2B and related sporadic tumours
    C Eng
    Department of Pathology, University of Cambridge, UK
    Hum Mol Genet 3:237-41. 1994
    ..DNA from five of 13 apparently sporadic MTC and one of 12 apparently sporadic phaeochromocytomas harboured a similar mutation, but the corresponding germline DNA was wildtype in each case...
  97. ncbi DOS, a novel pleckstrin homology domain-containing protein required for signal transduction between sevenless and Ras1 in Drosophila
    T Raabe
    Theodor Boveri Institut für Biowissenschaften, Lehstuhl für Genetik, Universitat Wurzburg, Federal Republic of Germany
    Cell 85:911-20. 1996
    ..Our genetic analysis demonstrates that DOS functions upstream of Ras1 and defines a signaling pathway that is independent of direct binding of the DRK SH2/SH3 adaptor protein to the SEV receptor tyrosine kinase...
  98. ncbi Ror receptor tyrosine kinases: orphans no more
    Jennifer L Green
    Department of Developmental Biology, Stanford University School of Medicine, Beckman Center, B269, 279 Campus Drive, Stanford, CA 94305 5323, USA
    Trends Cell Biol 18:536-44. 2008
    ..New evidence implicates Ror proteins in planar cell polarity, an alternative Wnt pathway. Here, we review the progress made in understanding these mysterious proteins and, in particular, we focus on their function as Wnt receptors...
  99. ncbi The relationship between specific RET proto-oncogene mutations and disease phenotype in multiple endocrine neoplasia type 2. International RET mutation consortium analysis
    C Eng
    Division of Cancer Epidemiology and Control, Dana Farber Cancer Institute, Department of Medicine, Harvard Medical School, Boston, MA 02115 6084, USA
    JAMA 276:1575-9. 1996
    ..The purpose of this study was to establish the relationship between specific mutations and the presence of certain disease features in MEN 2 which could help in clinical decision making...
  100. ncbi Murine FGFR-1 is required for early postimplantation growth and axial organization
    C X Deng
    Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts 02115
    Genes Dev 8:3045-57. 1994
    ..Such abnormalities are unlikely to be caused by intrinsic blocks in mesodermal differentiation, as FGFR-1-deficient ES cell lines form teratomas consisting of many mesodermal cell types...
  101. ncbi Expression of the c-ret proto-oncogene during mouse embryogenesis
    V Pachnis
    Department of Genetics and Development, Columbia University, New York, NY 10032
    Development 119:1005-17. 1993
    ....

Research Grants63

  1. Mechanisms of Overexpressed TrkB in Inducing Pancreatic Cancer Metastasis
    Paul J Chiao; Fiscal Year: 2013
    ..Targeting specific mutations and signaling pathways in pancreatic cancer may be one of the novel therapeutic interventions to treat cancer metastasis. ..
  2. Role of CD148 Tyrosine Phosphatase in Angiogenesis
    Takamune Takahashi; Fiscal Year: 2013
    ..Given the fact that endothelial receptor protein tyrosine kinases (RPTKs) play a major role in transduction of angiogenic signals, we hypothesized that endothelial ..
  3. Role of CD148 Tyrosine Phosphatase in Diabetic Nephropathy
    Takamune Takahashi; Fiscal Year: 2013
    ..Given the fact that endothelial receptor protein tyrosine kinases (RPTKs) play a major role in transduction of angiogenic signals, we have advanced the hypothesis ..
  4. Structural Studies of the Pseudokinase Domain of Jak2.
    Stevan R Hubbard; Fiscal Year: 2013
    ..To achieve this goal, x-ray crystallography will be employed to determine the three-dimensional structures of the pseudokinase domain and the tandem pseudokinase and tyrosine kinase domains. ..
  5. Functions of EPH Receptors and Ephrins in Neuroblastoma
    Naohiko Ikegaki; Fiscal Year: 2005
    ..Results of this study would reveal novel mechanisms by which EPHB6 and ephrin-B ligands restrict growth, angiogenesis and metastasis of NB. Such knowledge may help develop an innovative and effective treatment for unfavorable NB. ..
  6. EXPRESSION AND REGULATION OF ATRIAL NATRIURETIC FACTOR
    David Gardner; Fiscal Year: 2002
    ..A number of signaling pathways (e.g. ERK, JNK, p38 MAPK, PKC, non receptor protein tyrosine kinases, etc...
  7. Desensitization of Vascular Receptor Tyrosine Kinases
    Neil Freedman; Fiscal Year: 2009
    ..death in the industrialized world, atherosclerosis fundamentally involves cellular signaling through receptor protein tyrosine kinases (RPTKs)...
  8. ALTERED EGF RECEPTORS IN HUMAN GLIAL TUMORS
    Albert Wong; Fiscal Year: 2001
    DESCRIPTION: (Applicant's Abstract) Receptor protein tyrosine kinases (RPTKs) are essential to the pathogenesis of human glial tumors...
  9. Early Detection of Premalignant Lesions in Oral Cancer
    Keiko Watanabe; Fiscal Year: 2010
    ..The long-term goal is the development of a non-invasive screening test to detect premalignant lesions and thus potential malignancy in oral SCC. ..
  10. ROLE OF CD44 IN PERIPHERAL NERVE DEVELOPMENT AND INJURY
    Larry Sherman; Fiscal Year: 2004
    ..One key signal is glial growth factor (GGF), which activates heterodimers of the receptor protein tyrosine kinases erbB2 and erbB3 in Schwann cells...
  11. CYTOSKELETAL REGULATION BY SRC64/TEC29 KINASES
    Michael Simon; Fiscal Year: 2004
    Members of the SRC family of non-receptor protein tyrosine kinases (SFKs) play crucial roles in the regulation of cellular growth, differentiation, and morphology...
  12. MOLECULAR MECHANISMS OF RPE PHAGOCYTOSIS--ROLE OF CD36
    Roy Silverstein; Fiscal Year: 2002
    ..Similarly the role of CD36 interactions with cytoskeletal elements and non-receptor protein tyrosine kinases in internalization will be studied...
  13. DEVELOPMENT OF PATTERNED VISUAL CONNECTIONS IN THE BRAIN
    STEVEN MCLOON; Fiscal Year: 1999
    ..The fourth specific aim is to study the effect of altering expression of other Eph receptor protein tyrosine kinases on the pattern of retinotectal connections using approaches similar to those described for Cek4...
  14. PDGF-RECEPTOR KINASE INHIBITORS FOR ATHEROSCLEROSIS
    Alexandria Stewart; Fiscal Year: 1991
    ..The potential importance of finding a drug which inhibits PDGF action is underlined by the fact that in the USE alone about 765,000 people die of heart disease, and 154,000 of cerebrovascular diseases annually...
  15. PTK GENE MUTATIONS IN GENETIC DISORDERS AND CANCER
    Naohiko Ikegaki; Fiscal Year: 2002
    ..4) they will examine if DRT is mutated in NB cell lines and tumors. Results of this study should provide important insights into the biology and genetics of neuroblastoma and ultimately may lead to a therapeutic approach. ..
  16. PI3-KINASE IN SYNAPTIC PLASTICITY
    Pietro Sanna; Fiscal Year: 2001
    ..In particular we will explore the role of receptor protein tyrosine kinases and GPCR such as the glutamatergic metabotropic receptors, both of which can recruit PI3-kinases...
  17. TRANSCRIPTIONAL REGULATION OF CELL GROWTH
    Inder Verma; Fiscal Year: 2005
    ..There is an extensive synergy and interdependence among various projects and cores to allow fruitful collaboration to delineate the complex molecular events leading to uncontrolled growth of a cell. ..
  18. Regulation of Synaptic Morphology by Growth Factors
    Randall Walikonis; Fiscal Year: 2007
    ..These studies will provide the basis for further studies on the mechanisms by which Met regulates synaptic structure. [unreadable] [unreadable]..
  19. Regulation and Function of ECK in Apoptosis
    Yuxin Yin; Fiscal Year: 2005
    ..Characterization of ECK as a cell death receptor may reveal a new target for gene therapy or lead to the development of effective chemotherapeutical strategies in cancer treatment. ..
  20. SIGNAL TRANSDUCTION BY THE ECK RECEPTOR TYROSINE KINASE
    Claudius Vincenz; Fiscal Year: 1999
    DESCRIPTION (Adapted from Investigator's Abstract): Receptor protein tyrosine kinases (RPTKs) are of fundamental importance in processes such as cell proliferation, survival, and differentiation...
  21. Brk interaction with ErbB receptors alters cell fate
    Julie Ostrander; Fiscal Year: 2006
    ..A better understanding of Brk's biochemical properties and role in breast cancer may provide clues to effective targeting of Brk or Brk-dependent signaling pathways. [unreadable] [unreadable] [unreadable] [unreadable]..
  22. B61 FUNCTION DURING VASCULAR DEVELOPMENT
    Joseph Ruiz; Fiscal Year: 2001
    ..It is anticipated that these data will provide insight into the function of the B61/ECK signaling pathway in vascular development during embryogenesis and tumorigenesis. ..
  23. Selective Inhibitors of SRC Family Kinases in Neoplasia
    THOMAS SMITHGALL; Fiscal Year: 2002
    ..Combined with the in vitro assays, we hope to identify novel inhibitory activities that target specific Src kinase isoforms and oncogenic signaling pathways. ..
  24. C KIT SIGNALLING REQUIREMENTS IN TCR LINEAGE COMMITMENT
    Lynn Puddington; Fiscal Year: 1999
    ....
  25. SYNTHESIS OF ANTITUMOR ANSAMYCINS
    JAMES KALLMERTEN; Fiscal Year: 1999
    ..activity of the benzoquinoid ansamycins stems from their inhibitory action against receptor and non-receptor protein tyrosine kinases (PTKs), an observation with significant implications for efforts to develop antitumor and antiviral ..
  26. CELL AUTONOMOUS MARKING SYSTEM
    SIMON MICHAEL; Fiscal Year: 1999
    ..IV) To cross the two lines generated in II and III to generate embryos carrying both the recombinase and reporter loci and analyze them at successive stages of development to map the fate of cells expressing eck. ..
  27. SKAP55 Negatively Regulates T Cell Receptor Signaling
    Karena Kosco; Fiscal Year: 2005
    ..Non-receptor protein tyrosine kinases (PTKs) link the TCR with proximal signaling events through tyrosine phosphorylation of multiple ..
  28. FUNCTIONAL DISSECTION OF THE EGF RECEPTOR BY MUTAGENESIS
    CHERYL GUYER; Fiscal Year: 2000
    ..3) To investigate the participation of Src family kinases in the stimulation of DNA synthesis by kinase-negative EGF receptors. ..
  29. IMMUNOMETRIC ASSAY FOR ACTIVATED KINASES
    CRAIG SORENSEN; Fiscal Year: 1993
    ..The ultimate goal of these studies will be to provide a tool to allow earlier diagnosis and better management of the cancer patient...
  30. CA TRANSPORTER EXPRESSION IN HYPERTROPHY & HEART FAILURE
    Allen Samarel; Fiscal Year: 2003
    ..abstract_text> ..
  31. HISTOCHEMICAL ASSAY FOR ACTIVATED PROTEIN KINASES
    CRAIG SORENSEN; Fiscal Year: 1993
    ..The ultimate goal of these studies will be to provide a tool to allow earlier diagnosis and better management of the cancer patient...
  32. ROLE IN SHC IN NORMAL AND MALIGNANT SIGNAL TRANSDUCTION
    Peter van der Geer; Fiscal Year: 2002
    ..In addition, they will determine the differences in signaling between Shc and Grb2 following growth factor receptor activation and they propose to purify a Shc-binding protein from Src-transformed fibroblasts. ..
  33. Novel Single, Dual and Multitargeted Inhibitors of RTKs
    Aleem Gangjee; Fiscal Year: 2007
    ..abstract_text> ..
  34. Alpha Folate Receptor Mediated GARFTase Inhibitors as Selective Antitumor Agents
    Aleem Gangjee; Fiscal Year: 2010
    ....
  35. Novel, P. jirovecii Specific Antipneumocystis Agents
    Aleem Gangjee; Fiscal Year: 2009
    ..These agents could be used alone or in combination to treat PCP thus providing novel agents against a new target. ..
  36. Single Agents with Designed Combination Chemotherapy Potential
    Aleem Gangjee; Fiscal Year: 2010
    ..abstract_text> ..
  37. Antitumor Antimitotics That Reverse Tumor Resistance
    Aleem Gangjee; Fiscal Year: 2010
    ..The study will also further define the mechanism of action of the novel series and could afford agents for clinical use. ..
  38. NOVEL NONINDUCIBLE THYMIDYLATE SYNTHASE INHIBITORS
    Aleem Gangjee; Fiscal Year: 2004
    ....
  39. STRUCTURE BASED ANALOGS AS ANTIOPPORTUNISTIC AGENTS
    Aleem Gangjee; Fiscal Year: 2001
    ..The analogues synthesized will also be submitted for screening against tuberculosis (NIAID) parasitic diseases (WHO) and tumor cells in culture (NCI). ..
  40. Third Generation Antiopportunistic Agents
    Aleem Gangjee; Fiscal Year: 2003
    ..Screening against tuberculosis (NIAID) and tumor cells in culture (NCI) is also proposed. ..
  41. Examination of FLT3 Mutations in Acute Myeloid Leukemia
    Derek Stirewalt; Fiscal Year: 2006
    ..Together, the research proposal and educational program provide Dc Stirewalt with the skills to become an independent clinical investigator. ..
  42. Gas6/Mertk mediated phagocytosis of OS by RPE cells
    Michael Hall; Fiscal Year: 2005
    ..abstract_text> ..
  43. Targeting GRP78/BIP As An Adjunct Therapy For EGFR-positive Breast Cancer
    Marina Backer; Fiscal Year: 2008
    ..We expect that this data establish feasibility of clinical development for EGF-SLiP. [unreadable] [unreadable] [unreadable]..
  44. FUNCTIONAL STUDIES OF TYRO 3 FAMILY RECEPTORS
    Greg Lemke; Fiscal Year: 2004
    ..Together, these studies will reveal the basics of cell-to-cell signaling through Tyro 3, Axl, and Mer -- three receptors of genuine biological importance. ..
  45. Genetic Analysis of Intracellular Signaling Crosstalk
    WILLIS LI; Fiscal Year: 2006
    ..Results from this work should shed light on the mechanisms of signaling crosstalk that may be important for human pathogenesis as well as tumorigenesis. ..
  46. TAM Receptor Regulation of Innate Immunity
    GREG E LEMKE; Fiscal Year: 2011
    ..Together, these studies will provide basic insights into a new signaling system of critical importance to the regulation of immune responses and the development of autoimmunity. ..
  47. Network Interaction between EGFR and TGFbeta Pathways
    WILLIS LI; Fiscal Year: 2009
    ..abstract_text> ..
  48. REGULATION OF MACROPHAGE INOS EXPRESSION
    Ming hai Wang; Fiscal Year: 2001
    ..Second it will facilitate understanding of the role of MSP in regulating macrophage activities in inflammation. Further, this work may lead to novel approaches for decreasing tissue destruction in inflammation. ..
  49. Targeted Delivery of Anthrax Inhibitors
    Marina Backer; Fiscal Year: 2007
    ..In Phase II we will develop LFn-liposomes with combination of LF and EF inhibitors, validate these liposomes in animal models of anthrax infection, and pre-clinical steps required for IND filing. [unreadable] [unreadable] [unreadable]..
  50. Glial-Neuron Interactions: Genetic Studies
    Greg Lemke; Fiscal Year: 2005
    ..Together, these studies will yield fundamental new insights into the transcriptional regulation of glial-neuron interactions in the developing central and peripheral nervous systems. ..
  51. Mechanisms of Central Autonomic Orchestration of Blood Pressure
    Rajanikanth Vadigepalli; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
  52. MURINE STK RECEPTOR AND MACROPHAGE ACTIVATION
    PAMELA CORRELL; Fiscal Year: 2002
    ..By understanding, in more detail, the regulation of macrophage activation, the PI hopes to begin to identify targets for suppression of the tissue-damaging effects of inflammation without compromising the host immune response. ..
  53. MEDIATORS OF BLOOD-RETINAL BARRIER BREAKDOWN
    STANLEY VINORES; Fiscal Year: 2002
    ....
  54. Accurate Prediction of Acute Myeloid Leukemia Relapse
    Soheil Meshinchi; Fiscal Year: 2005
    ..With these enhancements and modifications, we believe we will be able to accurately predict relapse in more than 80% of children with AML who achieve remission. ..
  55. CAM-1 RTK FUNCTION IN CELL MIGRATION AND CELL POLARITY
    WAYNE FORRESTER; Fiscal Year: 2003
    ....
  56. Role of the STK Receptor in Erythropoiesis
    Pamela Hankey; Fiscal Year: 2009
    ....
  57. Targeting FLT3 as a Novel Specific Therapy for Leukemia
    Mark Levis; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  58. Prognostic implications of Flt3 mutations in AML
    Soheil Meshinchi; Fiscal Year: 2004
    ..This grant project will undertake an extensive evaluation of Flt3 mutations in the largest patient population tested to date and will correlate the data with other biologic markers. ..
  59. DDR1 controls tumor homing in breast to bone metastasis
    Celso Gomez Sanchez; Fiscal Year: 2004
    ..A survey of the CRISP database showed that the NIH currently funds no other research on DDR1. ..
  60. Docking protein FRS2 in FGF signaling
    Joseph Schlessinger; Fiscal Year: 2008
    ..abstract_text> ..
  61. Sensitivity of various FLT3 mutations to FLT3 inhibitors
    Jennifer Clark; Fiscal Year: 2004
    ..This proposal aims to characterize FLT3 mutations in AML, to identify mutations that confer resistance to the available FLT3 inhibitors, and to identify novel mutations in AML as potential targets for therapy. ..
  62. FGF RECEPTOR SIGNALING IN BONE DEVELOPMENT
    Joseph Schlessinger; Fiscal Year: 2009
    ....
  63. Role of ErbB/Stat3 in the establishment and progression of pancreatic cancer
    James Freeman; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..