Genomes and Genes
purinergic p2 receptors
Summary: A class of cell surface receptors for purines that prefer ATP or ADP over adenosine. P2 purinergic receptors are widespread in the periphery and in the central and peripheral nervous system. Subtypes have been proposed, usually designated P2 x, y, z, and t. P2x receptors may mediate fast synaptic transmission by ATP. The ADP-preferring P2t receptors in platelets stimulate aggregation.
Publications278 found, 100 shown here
- Molecular physiology of P2X receptorsR Alan North
Institute of Molecular Physiology, University of Sheffield, Western Bank, Sheffield, United Kingdom
Physiol Rev 82:1013-67. 2002..In the last case, P2X7 receptor activation stimulates cytokine release by engaging intracellular signaling pathways...
- Receptors for purines and pyrimidinesV Ralevic
School of Biomedical Sciences, Queen s Medical Centre, University of Nottingham, Nottingham, England
Pharmacol Rev 50:413-92. 1998
- Pannexin-1 mediates large pore formation and interleukin-1beta release by the ATP-gated P2X7 receptorPablo Pelegrin
Department of Biomedical Science, University of Sheffield, Sheffield, UK
EMBO J 25:5071-82. 2006....
- Liaisons dangereuses: P2X(7) and the inflammasomeFrancesco Di Virgilio
Department of Experimental and Diagnostic Medicine, Section of General Pathology, University of Ferrara, Via Borsari, 46, Ferrara, Italy
Trends Pharmacol Sci 28:465-72. 2007....
- Crystal structure of the ATP-gated P2X(4) ion channel in the closed stateToshimitsu Kawate
Vollum Institute, Oregon Health and Science University, 3181 Southwest Sam Jackson Park Road, Oregon 97239, USA
Nature 460:592-8. 2009..We define the location of three non-canonical, intersubunit ATP-binding sites, and suggest that ATP binding promotes subunit rearrangement and ion channel opening...
- Pharmacological profiles of cloned mammalian P2Y-receptor subtypesIvar von Kügelgen
Department of Pharmacology, University of Bonn, Reuterstrasse 2b, D 53113 Bonn, Germany
Pharmacol Ther 110:415-32. 2006..Finally, UDP has been reported to act on receptors for cysteinyl leukotrienes as an additional agonist--indicating a dual agonist specificity of these receptors...
- Fluorescence-detection size-exclusion chromatography for precrystallization screening of integral membrane proteinsToshimitsu Kawate
Department of Biochemistry and Molecular Biophysics, Columbia University, 650 West 168 th Street, New York, New York 10032, USA
Structure 14:673-81. 2006..We show the application of this precrystallization screening to four membrane proteins derived from prokaryotic or eukaryotic organisms...
- ATP is released by monocytes stimulated with pathogen-sensing receptor ligands and induces IL-1beta and IL-18 secretion in an autocrine wayAlessandra Piccini
Cell Biology Unit, National Cancer Research Institute, Largo Rosanna Benzi 10, 16132 Genoa, Italy
Proc Natl Acad Sci U S A 105:8067-72. 2008..Thus, stimuli acting on different pathogen-sensing receptors converge on a common pathway where ATP externalization is the first step in the cascade of events leading to inflammasome activation and IL-1beta and IL-18 secretion...
- International Union of Pharmacology LVIII: update on the P2Y G protein-coupled nucleotide receptors: from molecular mechanisms and pathophysiology to therapyMaria P Abbracchio
Department of Pharmacological Sciences, University of Milan, Milan, Italy
Pharmacol Rev 58:281-341. 2006..These and other advances are discussed in the present review...
- Prasugrel versus clopidogrel in patients with acute coronary syndromesStephen D Wiviott
Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
N Engl J Med 357:2001-15. 2007..Dual-antiplatelet therapy with aspirin and a thienopyridine is a cornerstone of treatment to prevent thrombotic complications of acute coronary syndromes and percutaneous coronary intervention...
- Pannexin1 is part of the pore forming unit of the P2X(7) receptor death complexSilviu Locovei
Department of Physiology and Biophysics, University of Miami School of Medicine, 1600 NW 10th Ave, Miami, FL 33136, USA
FEBS Lett 581:483-8. 2007..Thus, pannexin1 appears to be the molecular substrate for the permeabilization pore (or death receptor channel) recruited into the P2X(7)R signaling complex...
- Nucleotide receptors: an emerging family of regulatory molecules in blood cellsF Di Virgilio
Department of Experimental and Diagnostic Medicine, Section of General Pathology and Medical Genetics, and Center of Biotechnology, University of Ferrara, Ferrara, Italy
Blood 97:587-600. 2001..These effects are mediated through a specific class of plasma membrane receptors called purinergic P2 receptors that, according to the molecular structure, are further subdivided into 2 subfamilies: P2Y and P2X...
- Purine and pyrimidine receptorsG Burnstock
Autonomic Neuroscience Centre, Royal Free and University College Medical School, London, UK
Cell Mol Life Sci 64:1471-83. 2007..P2Y receptors are G protein-coupled receptors, and eight subtypes have been cloned and characterised to date...
- Deletion of the P2X7 nucleotide receptor reveals its regulatory roles in bone formation and resorptionHua Zhu Ke
Pfizer Global Research and Development, Groton Laboratories, Connecticut 06340, USA
Mol Endocrinol 17:1356-67. 2003..Thus, the P2X7 receptor represents a novel therapeutic target for the management of skeletal disorders such as osteoporosis...
- Pathophysiology and therapeutic potential of purinergic signalingGeoffrey Burnstock
Autonomic Neuroscience Centre, Royal Free and University College Medical School, London NW3 2PF, UK
Pharmacol Rev 58:58-86. 2006..Recent advances in therapies using purinergic-related drugs in a wide range of pathological conditions will be addressed with speculation on future developments in the field...
- Central role of the P2Y12 receptor in platelet activationRobert T Dorsam
Department of Pharmacology, Temple University Medical School, Philadelphia, Pennsylvania 19140, USA
J Clin Invest 113:340-5. 2004..The P2Y(12) receptor, activated by ADP, plays a central role in platelet activation and is the target of P2Y(12) receptor antagonists that have proven therapeutic value...
- Identification of the platelet ADP receptor targeted by antithrombotic drugsG Hollopeter
Department of Cellular and Molecular Pharmacology, University of California, San Francisco 94143, USA
Nature 409:202-7. 2001..Cloning of the P2Y12 receptor should facilitate the development of better antiplatelet agents to treat cardiovascular diseases...
- Cellular distribution and functions of P2 receptor subtypes in different systemsGeoffrey Burnstock
Autonomic Neuroscience Institute, Royal Free and University College Medical School, London NW3 2PF, United Kingdom
Int Rev Cytol 240:31-304. 2004..Finally, there is some discussion of possible future developments in the purinergic signaling field...
- Peripheral inflammation sensitizes P2X receptor-mediated responses in rat dorsal root ganglion neuronsGuang Yin Xu
Marine Biomedical Institute and Department of Physiology and Biophysics, University of Texas Medical Branch, Galveston, Texas 77555 1069, USA
J Neurosci 22:93-102. 2002..These results suggest that P2X receptors are useful targets for inflammatory pain therapy...
- Adenosine diphosphate-induced platelet aggregation is associated with P2Y12 gene sequence variations in healthy subjectsPierre Fontana
Service d Hématologie Biologique A, Hôpital Européen Georges Pompidou and Inserm Unité 428, Faculte des Sciences Pharmaceutiques et Biologiques, Universite Paris V, Paris, France
Circulation 108:989-95. 2003..Some studies have shown interindividual differences in ADP-induced platelet aggregation responses ex vivo, but the mechanisms underlying this variability are unknown...
- P2X(7) receptor blockade prevents ATP excitotoxicity in oligodendrocytes and ameliorates experimental autoimmune encephalomyelitisCarlos Matute
Departamento de Neurociencias, Universidad del Pais Vasco, 48940 Leioa, Spain
J Neurosci 27:9525-33. 2007..Thus, P2X(7) receptor antagonists may be beneficial for the treatment of MS...
- P2X4 receptors induced in spinal microglia gate tactile allodynia after nerve injuryMakoto Tsuda
Division of Biosignaling, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagaya, Tokyo 158 8501, Japan
Nature 424:778-83. 2003..Thus, blocking P2X4Rs in microglia might be a new therapeutic strategy for pain induced by nerve injury...
- P2X4-receptor-mediated synthesis and release of brain-derived neurotrophic factor in microglia is dependent on calcium and p38-mitogen-activated protein kinase activationTuan Trang
Program in Neurosciences and Mental Health, Hospital for Sick Children, Toronto, Ontario, Canada M5G 1X8
J Neurosci 29:3518-28. 2009....
- P2X2 knockout mice and P2X2/P2X3 double knockout mice reveal a role for the P2X2 receptor subunit in mediating multiple sensory effects of ATPDebra A Cockayne
Roche Palo Alto, 3431 Hillview Avenue, Palo Alto, CA 94304, USA
J Physiol 567:621-39. 2005..Taken together, these data extend our findings for P2X3-/- mice, and reveal an important contribution of heteromeric P2X2/3 receptors to nociceptive responses and mechanosensory transduction within the urinary bladder...
- Priming of macrophages with lipopolysaccharide potentiates P2X7-mediated cell death via a caspase-1-dependent mechanism, independently of cytokine productionRosalind A Le Feuvre
School of Biological Sciences, University of Manchester, Oxford Road, Manchester M13 9PT, United Kingdom
J Biol Chem 277:3210-8. 2002....
- A Glu-496 to Ala polymorphism leads to loss of function of the human P2X7 receptorB J Gu
Departments of Medicine and Anatomy and Histology, University of Sydney, Sydney, New South Wales 2006
J Biol Chem 276:11135-42. 2001..P2X(7)-mediated apoptosis of lymphocytes was impaired in homozygous mutant P2X(7) compared with germline (8.6 versus 35.2%). The data suggest that the glutamic acid at position 496 is required for optimal assembly of the P2X(7) receptor...
- P2X7 mediates superoxide production in primary microglia and is up-regulated in a transgenic mouse model of Alzheimer's diseaseLav K Parvathenani
Neuroscience Drug Discovery, Pharmaceutical Research Institute, Bristol Myers Squibb Co, Wallingford, Connecticut 06492, USA
J Biol Chem 278:13309-17. 2003..Consistent with this hypothesis, P2X(7) receptor was specifically up-regulated around beta-amyloid plaques in a mouse model of Alzheimer's disease (Tg2576)...
- Mechanisms of release of nucleotides and integration of their action as P2X- and P2Y-receptor activating moleculesEduardo R Lazarowski
Department of Pharmacology, University of North Carolina School of Medicine, CB 7365, Chapel Hill, NC 27599, USA
Mol Pharmacol 64:785-95. 2003
- Functional and molecular diversity of purinergic ion channel receptorsA B MacKenzie
Institute of Molecular Physiology, University of Sheffield, England, UK
Ann N Y Acad Sci 868:716-29. 1999..Further phenotypes can be produced when two subunits are coexpressed, indicating hetero-multimerization. This chapter compares the properties of the native P2X receptors with those of the cloned and expressed subunits...
- Defective platelet aggregation and increased resistance to thrombosis in purinergic P2Y(1) receptor-null miceC Leon
Institut National de la Santé et de la Recherche Médicale INSERM U 311, Etablissement de Transfusion Sanguine, 10, rue Spielmann, B P 36, 67065 Strasbourg, France
J Clin Invest 104:1731-7. 1999..Hence, the P2Y(1) receptor plays an essential role in thrombotic states and represents a potential target for antithrombotic drugs...
- The P2X7 receptor: a key player in IL-1 processing and releaseDavide Ferrari
Department of Experimental and Diagnostic Medicine, Section of General Pathology, University of Ferrara, Italy
J Immunol 176:3877-83. 2006....
- Decreased platelet aggregation, increased bleeding time and resistance to thromboembolism in P2Y1-deficient miceJ E Fabre
Department of Medicine, University of North Carolina, CB 7248, Chapel Hill, Thurston Bowles Bld, Durham, North Carolina, USA
Nat Med 5:1199-202. 1999..These findings support the hypothesis that the ATP receptor P2Y1 is a principal receptor mediating both physiologic and pathological ADP-induced processes in platelets...
- Related adhesion focal tyrosine kinase and the epidermal growth factor receptor mediate the stimulation of mitogen-activated protein kinase by the G-protein-coupled P2Y2 receptor. Phorbol ester or [Ca2+]i elevation can substitute for receptor activationS P Soltoff
Division of Signal Transduction, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
J Biol Chem 273:23110-7. 1998..Although P2Y2 and EGF receptors may both activate a similar multiprotein signaling cascade immediately upstream of MAP kinase, the P2Y2 receptor appears to uniquely utilize [Ca2+]i, PKC, and, subsequently, RAFTK...
- Reduced expression of P2Y1 receptors in connexin43-null mice alters calcium signaling and migration of neural progenitor cellsEliana Scemes
Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York 10461, USA
J Neurosci 23:11444-52. 2003....
- The cytolytic P2Z receptor for extracellular ATP identified as a P2X receptor (P2X7)A Surprenant
Glaxo Institute for Molecular Biology, Geneva, Switzerland
Science 272:735-8. 1996..Thus, the P2X7 (or P2Z) receptor is a bifunctional molecule that could function in both fast synaptic transmission and the ATP-mediated lysis of antigen-presenting cells...
- P2X7 receptors in the nervous systemBeata Sperlagh
Department of Pharmacology, Institute of Experimental Medicine, Hungarian Academy of Sciences, H 1450 Budapest, Hungary
Prog Neurobiol 78:327-46. 2006....
- ATP-gated ion channel P2X(3) is increased in human inflammatory bowel diseaseY Yiangou
Peripheral Neuropathy Unit, Imperial College School of Medicine, Hammersmith Hospital, London, UK
Neurogastroenterol Motil 13:365-9. 2001..01). In humans, unlike rodents, P2X(3) is thus not restricted to sensory neurones. Increased P2X(3) in inflamed intestine suggests a potential role in dysmotility and pain, for which it represents a new therapeutic target...
- Adenosine diphosphate (ADP)-induced thromboxane A(2) generation in human platelets requires coordinated signaling through integrin alpha(IIb)beta(3) and ADP receptorsJianguo Jin
Department of Physiology, Temple University Medical School, Philadelphia, PA 19140, USA
Blood 99:193-8. 2002....
- Ticagrelor versus clopidogrel in patients with acute coronary syndromesLars Wallentin
Uppsala Clinical Research Center, Uppsala, Sweden
N Engl J Med 361:1045-57. 2009..Ticagrelor is an oral, reversible, direct-acting inhibitor of the adenosine diphosphate receptor P2Y12 that has a more rapid onset and more pronounced platelet inhibition than clopidogrel...
- The role of purinergic P2X7 receptors in the inflammation and fibrosis of unilateral ureteral obstruction in miceR G Gonçalves
Lab Multidisciplinar de Pesquisa, Servico de Nefrologia, Hospital Universitario Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, Brazil
Kidney Int 70:1599-606. 2006..These findings constitute the first evidence that P2X7 receptors are implicated in macrophage infiltration, collagen deposition and apoptosis in response to ureteral obstruction in mice...
- Activation of P2X7 receptors in glial satellite cells reduces pain through downregulation of P2X3 receptors in nociceptive neuronsYong Chen
Department of Neuroscience and Cell Biology, University of Texas Medical Branch, Galveston, TX 77555 1069, USA
Proc Natl Acad Sci U S A 105:16773-8. 2008..Thus, direct blocking P2X7Rs, as proposed before, may not be the best strategy for reducing pain or lessening neuronal degeneration because it also disrupts the protective function of P2X7Rs...
- P2X(2)- and P2X(3)-positive fibers in fungiform papillae originate from the chorda tympani but not the trigeminal nerve in rats and miceYusuke Ishida
Department of Neurobiology and Anatomy, Graduate School of Medical Sciences, Nagoya City University, Nagoya 467 8601, Japan
J Comp Neurol 514:131-44. 2009..Taken together, these findings suggest that most P2X(2) and P2X(3) receptors in fungiform papillae are used for gustation rather than somatosensation...
- Analysis of assembly and trafficking of native P2X4 and P2X7 receptor complexes in rodent immune cellsMiyyada Boumechache
Department of Pharmacology, University of Cambridge, Cambridge CB2 1PD
J Biol Chem 284:13446-54. 2009..2-fold increase in total expression. The redistribution of intracellular receptors is thus an efficient means of enhancing the functional expression of P2X4 at the plasma membrane of microglia...
- Amino acid residues involved in gating identified in the first membrane-spanning domain of the rat P2X(2) receptorL H Jiang
Institute of Molecular Physiology, University of Sheffield, Alfred Denny Building, Western Bank, Sheffield S10 2TN, United Kingdom
J Biol Chem 276:14902-8. 2001..The results suggest that Val(48) at the outer end of the first hydrophobic segment takes part in the gating movement of channel opening...
- Altered cytokine production in mice lacking P2X(7) receptorsM Solle
Department of Respiratory, Allergy, Immunology, Inflammation, and Infectious Diseases, Pfizer Inc, Groton, Connecticut 06340, USA
J Biol Chem 276:125-32. 2001..Together these results demonstrate that P2X(7)R activation can provide a signal that leads to maturation and release of IL-1 beta and initiation of a cytokine cascade...
- P2X7 receptor cell surface expression and cytolytic pore formation are regulated by a distal C-terminal regionMegan L Smart
Department of Physiology, The University of Melbourne, Victoria 3010, Australia
J Biol Chem 278:8853-60. 2003....
- Involvement of beta1 integrin in microglial chemotaxis and proliferation on fibronectin: different regulations by ADP through PKAKaoru Nasu-Tada
Division of Pharmacology, National Institute of Health Sciences, Setagaya, Tokyo, Japan
Glia 52:98-107. 2005..Together, these results indicate the involvement of beta1 integrin in microglial proliferation and chemotaxis, both of which have clinical importance. The data also suggest that PKA is inversely involved in these two cellular functions...
- An Ile-568 to Asn polymorphism prevents normal trafficking and function of the human P2X7 receptorJames S Wiley
Department of Medicine, University of Sydney at Nepean Hospital, Penrith, New South Wales 2750, Australia
J Biol Chem 278:17108-13. 2003..These data identify a second loss-of-function polymorphism within the P2X(7) receptor and show that Ile-568 is critical to the trafficking domain, which we have shown to lie between residues 551 and 581...
- Facilitation of P2X7 receptor currents and membrane blebbing via constitutive and dynamic calmodulin bindingSebastien Roger
Faculty of Life Science, University of Manchester, Manchester M13 9PT, United Kingdom
J Neurosci 28:6393-401. 2008..This is the first example of CaM deregulating, rather than tightly controlling, calcium entry through an ion channel...
- Immunohistochemical study of the P2X2 and P2X3 receptor subunits in rat and monkey sensory neurons and their central terminalsL Vulchanova
Graduate Program in Neuroscience, University of Minnesota, Minneapolis 55455, USA
Neuropharmacology 36:1229-42. 1997..These results suggest species differences, although a more extensive study of primate sensory systems is necessary...
- A Thr357 to Ser polymorphism in homozygous and compound heterozygous subjects causes absent or reduced P2X7 function and impairs ATP-induced mycobacterial killing by macrophagesAnne N Shemon
Department of Medicine, University of Sydney, Level 5, Spurrett Building, Nepean Hospital, Penrith, New South Wales 2750, Australia
J Biol Chem 281:2079-86. 2006..Lymphocytes, monocytes, and macrophages from subjects homozygous for T357S or compound heterozygous for T357S and a second loss-of-function allele have reduced or absent P2X(7) receptor function...
- Extracellular ATP causes ROCK I-dependent bleb formation in P2X7-transfected HEK293 cellsAnna Morelli
Department of Experimental and Diagnostic Medicine, Section of General Pathology, and Interdisciplinary Center for the Study of Inflammation, University of Ferrara, I 44100 Ferrara, Italy
Mol Biol Cell 14:2655-64. 2003..These observations suggest that P2X7-dependent plasma membrane blebbing depends on the activation of the serine/threonine kinase ROCK I...
- Regions of the amino terminus of the P2X receptor required for modification by phorbol ester and mGluR1alpha receptorsHairuo Wen
Department of Cell Physiology and Pharmacology, University of Leicester, Leicester, UK
J Neurochem 108:331-40. 2009..These results demonstrate that the conserved YXTXK/R sequence and a region with a conserved glycine residue close to the first transmembrane segment contribute to PMA and GPCR regulation of P2X(1) receptors...
- P2X7 receptor-stimulated secretion of MHC class II-containing exosomes requires the ASC/NLRP3 inflammasome but is independent of caspase-1Yan Qu
Department of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, OH 44120, USA
J Immunol 182:5052-62. 2009....
- N-methyl-D-glucamine and propidium dyes utilize different permeation pathways at rat P2X(7) receptorsLin Hua Jiang
Institute of Molecular Physiology, University of Sheffield, Western Bank, Sheffield S10 2TN, UK
Am J Physiol Cell Physiol 289:C1295-302. 2005..Together, the clear differential effects of extracellular sodium ions or of mutation of the receptor strongly suggest that N-methyl-d-glucamine and YO-PRO-1 do not enter the cell by the same permeation pathway...
- The nucleotide receptor P2Y13 is a key regulator of hepatic high-density lipoprotein (HDL) endocytosisS Jacquet
INSERM U563, Dpt Lipoprotéines et Médiateurs Lipidiques, Bat C, Hopital Purpan, 31024 Toulouse, France
Cell Mol Life Sci 62:2508-15. 2005..We also found a new important action of the antithrombotic agent AR-C69931MX as a strong activator of P2Y13-mediated HDL endocytosis...
- Involvement of P2X4 and P2Y12 receptors in ATP-induced microglial chemotaxisKeiko Ohsawa
Department of Neurochemistry, National Institute of Neuroscience, Kodaira, Tokyo 187 8502, Japan
Glia 55:604-16. 2007..These results indicate that P2X(4)R as well as P2Y(12)R is involved in ATP-induced microglial chemotaxis...
- A loss-of-function polymorphism in the human P2X7 receptor abolishes ATP-mediated killing of mycobacteriaBernadette M Saunders
Centenary Institute of Cancer Medicine and Cell Biology, Newtown, NSW Australia
J Immunol 171:5442-6. 2003..These data demonstrate that a single nucleotide polymorphism in the P2X7 gene can allow survival of mycobacteria within infected host cells...
- Contribution of individual subunits to the multimeric P2X(2) receptor: estimates based on methanethiosulfonate block at T336CR Stoop
Geneva Biomedical Research Institute, Glaxo Wellcome Research and Development, Geneva, Switzerland
Mol Pharmacol 56:973-81. 1999..The present results show that a "per-subunit" channel block causes the blocking effects of MTSET and they suggest that not four but maximally three subunits actively participate in the channel formation...
- Regulation of immune response by P2X7 receptorLanfen Chen
Department of Pathology, Albert Einstein College of Medicine, 1300 Morris Park Ave F 520, Bronx, NY 10461, USA
Crit Rev Immunol 26:499-513. 2006....
- The proinflammatory action of microglial P2 receptors is enhanced in SOD1 models for amyotrophic lateral sclerosisNadia D'Ambrosi
Santa Lucia Foundation, Rome, Italy
J Immunol 183:4648-56. 2009..Considering that extracellular ATP, through purinergic P2 receptors, constitutes a well recognized neuron-to-microglia alarm signal, the aim of this study was to investigate ..
- Adenosine triphosphate-induced shedding of CD23 and L-selectin (CD62L) from lymphocytes is mediated by the same receptor but different metalloproteasesB Gu
Sydney University Department of Medicine, Nepean Hospital, Penrith, Australia
Blood 92:946-51. 1998..However, different membrane metalloproteases seem to mediate the shedding of L-selectin and CD23...
- Common polymorphisms of CYP2C19 and CYP2C9 affect the pharmacokinetic and pharmacodynamic response to clopidogrel but not prasugrelJ T Brandt
Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA
J Thromb Haemost 5:2429-36. 2007..The pharmacodynamic response to clopidogrel is more variable than the response to prasugrel, but the reasons for variation in response to clopidogrel are not well characterized...
- Lipids regulate P2X7-receptor-dependent actin assembly by phagosomes via ADP translocation and ATP synthesis in the phagosome lumenMark P Kuehnel
EMBL, Meyerhofstr 1, 69117 Heidelberg, Germany
J Cell Sci 122:499-504. 2009..In the accompanying paper by Kuehnel et al. (doi:10.1242/jcs.034207), more evidence is provided in support of this model from the analysis of actin assembly at the plasma membrane of intact macrophages...
- The P2X7 receptor as a therapeutic targetRomeo Romagnoli
Universita di Ferrara, Dipartimento di Scienze Farmaceutiche, Via Fossato di Mortara 17 19, 44100 Ferrara, Italy
Expert Opin Ther Targets 12:647-61. 2008....
- Regulation of P2X2 receptors by the neuronal calcium sensor VILIP1Severine Chaumont
Department of Physiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA
Sci Signal 1:ra8. 2008..Our data thus reveal a previously unrecognized function for the neuronal calcium sensor protein VILIP1 and a mechanism for regulation of ATP-dependent P2X receptor signaling by neuronal calcium sensors...
- Cutting edge: a natural P451L mutation in the cytoplasmic domain impairs the function of the mouse P2X7 receptorSahil Adriouch
Universite Denis Diderot, Paris, France
J Immunol 169:4108-12. 2002..The effects of the P451L mutation resemble those of the E496A mutation in human P2X(7)R. These P2X(7)R mutants may provide useful tools to decipher the molecular mechanisms leading to pore formation...
- Identification of a trafficking motif involved in the stabilization and polarization of P2X receptorsSeverine Chaumont
Departement de Pharmacologie, Laboratoire de Génomique Fonctionnelle, CNRS UPR2580, 141 rue de la Cardonille, 34396 Montpellier, France
J Biol Chem 279:29628-38. 2004....
- Disordered purinergic signaling inhibits pathological angiogenesis in cd39/Entpd1-null miceShaun W Jackson
Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
Am J Pathol 171:1395-404. 2007..Our data indicate novel links between CD39/ENTPD1, extracellular nucleotide-mediated signaling, and vascular endothelial cell integrin function that impact on angiogenesis and tumor growth...
- ATP signaling is crucial for communication from taste buds to gustatory nervesThomas E Finger
Rocky Mountain Taste and Smell Center, Aurora CO 80045, USA
Science 310:1495-9. 2005..Finally, stimulation of taste buds in vitro evokes release of ATP. Thus, ATP fulfils the criteria for a neurotransmitter linking taste buds to the nervous system...
- Exacerbation of experimental autoimmune encephalomyelitis in P2X7R-/- mice: evidence for loss of apoptotic activity in lymphocytesLanfen Chen
Department of Pathology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
J Immunol 176:3115-26. 2006..From these data we conclude that enhanced susceptibility of P2X7R-/- mice to EAE reflects a loss of apoptotic activity in lymphocytes, supporting an important role for this receptor in lymphocyte homeostasis...
- Inhibition of platelet aggregation by AZD6140, a reversible oral P2Y12 receptor antagonist, compared with clopidogrel in patients with acute coronary syndromesRobert F Storey
Cardiovascular Research Unit, University of Sheffield, Sheffield, United Kingdom
J Am Coll Cardiol 50:1852-6. 2007..clopidogRel in non-ST-segment Elevation myocardial infarction)-2, we compared the antiplatelet effects of AZD6140 and clopidogrel and assessed the effects of AZD6140 in clopidogrel-pretreated patients...
- P2X7-like receptor activation in astrocytes increases chemokine monocyte chemoattractant protein-1 expression via mitogen-activated protein kinaseW Panenka
Neuroscience Research Group, University of Calgary, Calgary, Alberta, Canada T2N 4N1
J Neurosci 21:7135-42. 2001..The regulation of MCP-1 in astrocytes by ATP may be important in mediating communication with hematopoietic inflammatory cells...
- Involvement of P2X7 receptors in the regulation of neurotransmitter release in the rat hippocampusBeata Sperlagh
Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary
J Neurochem 81:1196-211. 2002..In conclusion, P2X7 Rs are localized to the excitatory terminals in the hippocampus, and their activation regulates the release of glutamate and GABA from themselves and from their target cells...
- Activation and desensitization of the recombinant P2X1 receptor at nanomolar ATP concentrationsJürgen Rettinger
Department of Molecular Pharmacology, Medical School, Technical University of Aachen, Germany
J Gen Physiol 121:451-61. 2003..Our results imply that nanomolar extracellular ATP concentrations can obscure P2X1 receptor responses by driving a significant fraction of the receptor pool into a long-lasting refractory closed state...
- Antinociceptive effect of a new P(2Z)/P2X7 antagonist, oxidized ATP, in arthritic ratsGiacomo Dell'antonio
Department of Pathology, IRCCS H S Raffaele, Via Olgettina 60, Milan, Italy
Neurosci Lett 327:87-90. 2002..The data indicate that the P2z/P2X7 receptor system exerts a role in nociception and that oATP, by inhibiting such a receptor, reduces the nociceptive signal in the course of peripheral inflammation...
- Upregulated expression of purinergic P2X(7) receptor in Alzheimer disease and amyloid-beta peptide-treated microglia and in peptide-injected rat hippocampusJames G McLarnon
Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver BC, Canada
J Neuropathol Exp Neurol 65:1090-7. 2006..The overall results suggest roles of P2X(7)R in mediating microglial purinergic inflammatory responses in AD brain...
- Desensitization, recovery and Ca(2+)-dependent modulation of ATP-gated P2X receptors in nociceptorsS P Cook
Vollum Institute L 474, Oregon Health Science University, Portland 97201 3098, USA
Neuropharmacology 36:1303-8. 1997..Mechanistic explanations for either the increase in transient current magnitude by elevated Ca2+ext, or persistent current overrecovery may reflect endogenous pathways for P2X receptor modulation...
- ATP and UTP at low concentrations strongly inhibit bone formation by osteoblasts: a novel role for the P2Y2 receptor in bone remodelingAstrid Hoebertz
Department of Anatomy and Developmental Biology, University College London, Gower Street, London WC1E 6BT, United Kingdom
J Cell Biochem 86:413-9. 2002..These findings suggest that extracellular nucleotides could function locally as important negative modulators of bone metabolism, perhaps contributing to bone loss in a number of pathological states...
- Interaction between cysteines introduced into each transmembrane domain of the rat P2X2 receptorValeria Spelta
Institute of Molecular Physiology, University of Sheffield, Western Bank, Sheffield S10 2TN, UK
Br J Pharmacol 138:131-6. 2003..It reversed the rapid current deactivation at F44C/L338C. 5 The results suggest that a methanethiosulfonate binding to L338C prevents binding to F44C; this might indicate proximity of these two residues...
- Patch-clamp coordinated spectroscopy shows P2X2 receptor permeability dynamics require cytosolic domain rearrangements but not Panx-1 channelsSeverine Chaumont
Departments of Physiology and Neurobiology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
Proc Natl Acad Sci U S A 105:12063-8. 2008..Finally, the data illustrate the utility of a new approach, using tetracysteine tags and biarsenical fluorophores to measure site-specific conformational changes in membrane proteins...
- Nucleotides induce IL-6 release from human airway epithelia via P2Y2 and p38 MAPK-dependent pathwaysChristelle D Douillet
Division of Trauma and Critical Care, Department of Surgery, University of North Carolina at Chapel Hill, 4008 Burnett Womack, Chapel Hill, NC 27599 7228, USA
Am J Physiol Lung Cell Mol Physiol 291:L734-46. 2006..This effect is dependent on transcription and translation. Our findings were confirmed in an in vivo model, thus demonstrating a novel mechanism of nucleotide-induced IL-6 secretion by airway epithelia...
- Diisothiocyanate derivatives as potent, insurmountable antagonists of P2Y6 nucleotide receptorsLiaman K Mamedova
Laboratory of Bioorganic Chemistry, Molecular Recognition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bldg 8A, Rm B1A 19, Bethesda, MD 20892 0810, USA
Biochem Pharmacol 67:1763-70. 2004..Thus, we have identified potent, insurmountable antagonists of P2Y(6) receptors that are selective within the family of PLC-coupled P2Y receptors...
- Cloning, pharmacological characterisation and distribution of the rat G-protein-coupled P2Y(13) receptorMarta Fumagalli
Department of Pharmacological Sciences, University of Milan, Via Balzaretti 9, Milan 20133, Italy
Biochem Pharmacol 68:113-24. 2004....
- Selective expression of Gi/o-coupled ATP receptor P2Y12 in microglia in rat brainYo Sasaki
Department of Neurochemistry, National Institute of Neuroscience, Kodaira, Tokyo, Japan
Glia 44:242-50. 2003..Hardly any P2Y12 mRNA was detected in macrophages obtained from the spleen and abdominal cavity, which share many surface molecules with microglia...
- Selective nucleotide-release from dense-core granules in insulin-secreting cellsStefanie Obermuller
Department of Experimental Medicinal Sciences, Lund University, BMC B11, SE 221 84 Lund, Sweden
J Cell Sci 118:4271-82. 2005..These observations suggest that insulin-secreting cells are able to use the same secretory vesicles to release small molecules either alone or together with the peptide hormone...
- Molecular characterization of the zebrafish P2X receptor subunit gene familyS Kucenas
Department of Pharmacological and Physiological Science, St Louis University School of Medicine, 1402 South Grand Boulevard, St Louis, MO 63104, USA
Neuroscience 121:935-45. 2003..These results suggest that P2X receptors might play a role in the early development and/or function of the sensory nervous system in vertebrates...
- P2X7 nucleotide receptor activation enhances IFN gamma-induced type II nitric oxide synthase activity in BV-2 microglial cellsFernand Pierre Gendron
Department of Biochemistry, University of Missouri Columbia, Columbia, Missouri 65212, USA
J Neurochem 87:344-52. 2003..These results suggest that activation of P2X7 receptors may contribute to inflammatory responses in microglial cells seen in neurodegenerative diseases...
- ATP-stimulated release of interleukin (IL)-1beta and IL-18 requires priming by lipopolysaccharide and is independent of caspase-1 cleavageV B Mehta
Dorothy M. Davis Heart and Lung Research Institute and Pulmonary and Critical Care Division, The Ohio State University, Columbus, Ohio 43210, USA
J Biol Chem 276:3820-6. 2001..Taken together, these results suggest that, although synthesis of IL-1beta and IL-18 differ, ATP-mediated release of both cytokines requires a priming step but not proteolytically functional caspase-1...
- P2 receptors activated by uracil nucleotides--an updateAndreas Brunschweiger
Pharmaceutical Institute, University of Bonn, Bonn, Germany
Curr Med Chem 13:289-312. 2006..They have also been proposed to play a role in neurodegenerative diseases. This article is an updated version of "P2-Pyrimidinergic Receptors and Their Ligands" by C. E. Müller published in Curr. Pharm. Des. 2002, 8, 2353-2369...
- Dynamic inhibition of excitatory synaptic transmission by astrocyte-derived ATP in hippocampal culturesSchuichi Koizumi
Division of Pharmacology, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagaya, Tokyo 158 8501, Japan
Proc Natl Acad Sci U S A 100:11023-8. 2003..We therefore conclude that ATP released from astrocytes exerts tonic and activity-dependent down-regulation of synaptic transmission via presynaptic mechanisms...
- Relief of inflammatory pain in rats by local use of the selective P2X7 ATP receptor inhibitor, oxidized ATPGiacomo Dell'antonio
IRCCS Hospital San Raffaele, Milan, Italy
Arthritis Rheum 46:3378-85. 2002..This study sought to determine the mechanism by which local administration of oATP is able to relieve inflammatory pain in arthritic rat paws...
- P2X(7) receptors: properties and relevance to CNS functionShumin Duan
Institute of Neuroscience and Key Laboratory of Neurobiology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
Glia 54:738-46. 2006....
- ATP stimulates mouse embryonic stem cell proliferation via protein kinase C, phosphatidylinositol 3-kinase/Akt, and mitogen-activated protein kinase signaling pathwaysJung Sun Heo
Department of Veterinary Physiology, Biotherapy Human Resources Center, College of Veterinary Medicine, Chonnam National University, Gwangju, Korea
Stem Cells 24:2637-48. 2006..In conclusion, ATP stimulates mouse ESC proliferation through PKC, PI3K/Akt, and MAPKs via the P2 purinoceptors...
- P2X7 receptor polymorphism impairs extracellular adenosine 5'-triphosphate-induced interleukin-18 release from human monocytesR Sluyter
Department of Medicine, University of Sydney at Nepean Hospital, Penrith NSW 2750, Australia
Genes Immun 5:588-91. 2004..ATP-induced ethidium(+) uptake in LPS-primed, monocytes of homozygous subjects was only 11% of that in wild-type monocytes, while P2X(7) surface expression on LPS-primed, homozygous monocytes was 44% of that on wild-type monocytes...
- An Arg307 to Gln polymorphism within the ATP-binding site causes loss of function of the human P2X7 receptorBen J Gu
Department of Medicine, University of Sydney at Nepean Hospital, Penrith, New South Wales 2750, Australia
J Biol Chem 279:31287-95. 2004....
- Coexpression of rat P2X2 and P2X6 subunits in Xenopus oocytesB F King
Autonomic Neuroscience Institute, Royal Free and University College Medical School, Royal Free Campus, Hampstead, London NW3 2PF, United Kingdom
J Neurosci 20:4871-7. 2000..Although homomeric P2X(6) receptors function poorly, the P2X(6) subunit can contribute to functional heteromeric P2X channels and may influence the phenotype of native P2X receptors in those cells in which it is expressed...
- Evidence that multiple P2X purinoceptors are functionally expressed in rat supraoptic neuronesI Shibuya
Department of Physiology, University of Occupational and Environmental Health, School of Medicine, Kitakyushu 807 8555, Japan
J Physiol 514:351-67. 1999..Such ionic and Ca2+-signalling mechanisms triggered by ATP may play an important role in the regulation of SON neurosecretory cells...
- A 5' intronic splice site polymorphism leads to a null allele of the P2X7 gene in 1-2% of the Caucasian populationKristen K Skarratt
Department of Medicine, University of Sydney at Nepean Hospital, Penrith, NSW, Australia
FEBS Lett 579:2675-8. 2005..The splice site mutation is an inherited polymorphism and gives rise to a P2X(7) null allele in 1-2% of the Caucasian population...
- Metabotropic P2 receptor activation regulates oligodendrocyte progenitor migration and developmentC Agresti
Department of Cell Biology and Neurosciences, Istituto Superiore di Sanita, Rome, Italy
Glia 50:132-44. 2005..These data indicate that ATP and ADP may regulate oligodendrocyte progenitor functions by a mechanism that involves mainly activation of P2Y(1) receptors...
- Morphine enhances microglial migration through modulation of P2X4 receptor signalingRyan J Horvath
Department of Pharmacology, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
J Neurosci 29:998-1005. 2009..These data provide the first necessary step in supporting microglial migration as an attractive target for the prevention or attenuation of morphine-induced side effects including tolerance and hyperalgesia...
- Novel Molecules in Calcium Signaling in PlateletsWolfgang Bergmeier; Fiscal Year: 2013..An in-depth analysis of how CD-GEFI regulates platelet function in vitro and in vivo will aid in its establishment as a target for antiplatelet therapy. ..
- Novel Antithrombotic Diadenosine Tetraphosphate AnalogsIVAN B YANACHKOV; Fiscal Year: 2010..The new drug will complement related drugs under development for arterial thrombosis. ..
- Role of Beta 3 Integrin in Skeletal MetastasisKatherine Weilbaecher; Fiscal Year: 2009..abstract_text> ..
- Regulation of Caspase-1 Signaling and Inflammation by the P2X7 ATP ReceptorGeorge R Dubyak; Fiscal Year: 2013..These studies will provide mechanistic insights that may facilitate development of adjuvant purinergic receptor-based therapies which increase the efficacy of immunogenic anti-tumor responses to primary cancer chemotherapeutic agents. ..
- Coronary PhysiologyEric O Feigl; Fiscal Year: 2010..This is a resubmission of RO1 HL 082781-01-A1 (This time as a modular grant.) ..
- Targeting Adiponectin Signaling: Novel Peptide Therapy for SclerodermaJohn Varga; Fiscal Year: 2013..The project is high impact since there are no approved treatments for scleroderma. Moreover, the results will have a strong impact on myriad fibrosing diseases that currently lack effective treatment. ..
- Antiplatelet Therapy: Platelet Inhibition, Polymorphisms, and Protein BiomarkersMarc S Sabatine; Fiscal Year: 2012....
- STUDY OF ACTIVITY-DEPENDENT SYMPATHETIC SPROUTINGJun Ming Zhang; Fiscal Year: 2013..We propose to continue the study of sympathetic component in neuropathic pain. Using a rat/mouse model, we will determine how abnormal activity, inflammation, ATP release affect sympathetic outgrowth and the neurons that sense pain. ..
- MOLECULAR BASIS FOR PLATELET FUNCTION IN HEMOSTASISRobert Colman; Fiscal Year: 2004..The knowledge gained from these studies will provide therapeutic approaches to enhancing hemostasis and preventing thrombosis. ..
- NPY AND ATP COTRANMISSION IN CHROMAFFIN CELLSTERRY HEXUM; Fiscal Year: 2003..Information will be provided which may lead to improved therapy of diseases particularly involving aberrations in transmission by catecholamines e.g., epilepsy, anorexia, alcoholism, and hypertension. ..
- Enhancing Thrombostatin's Oral DeliveryJohn Hilfinger; Fiscal Year: 2006..This project specifically involves the development of a new oral drug to treat heart attacks and cancer. [unreadable] [unreadable] [unreadable]..
- PURINOCEPTOR CONTROL OF SURFACTANT SECRETIONWard Rice; Fiscal Year: 1991....
- An ATP receptor-operated ionic conductance in ParameciumTodd Hennessey; Fiscal Year: 2002....
- CONTROL OF LUNG SURFACTANT SECRETION IN THE NEWBORNSEAMUS ROONEY; Fiscal Year: 1999..Such information is critical so that rational therapeutic interventions for prevention and/or control of the respiratory distress syndrome and other lung diseases may be developed. ..
- DEVELOPING SELECTIVE CALPAIN INHIBITORSISAAC DONKOR; Fiscal Year: 2000..The specific aims are: i) to identify the amino acid sequence at the active site of calpain to which inhibitors bind via affinity labeling; and ii) to synthesize compounds that will allow us to characterize the active site of calpain. ..
- ADENOSINE & KATP CHANNEL CONTROL OF CORONARY BLOOD FLOWERIC FEIGL; Fiscal Year: 2005..The proposed basic research is fundamental to understanding the normal coronary physiology that underlies coronary artery disease. ..
- MECHANISM OF CATION TRANSPORT REGULATIONLewis Cantley; Fiscal Year: 1993....
- INTERACTION OF PROGESTERONE RECEPTOR WITH ATPDavid Toft; Fiscal Year: 1980..The studies of this proposal are designed to firmly establish the existence and properties of the ATP-Receptor interaction and to clearly identify and describe activities of the receptor that involve nucleotide interactions. ..
- MAMMALIAN SPERM SURFACE ORGANIZATION AND FUNCTIONDiana Myles; Fiscal Year: 2002..Furthermore, the identified, functional gamete proteins are potential targets for novel contraceptive methods based on pharmacological and immunological approaches. ..
- Prolonged and Severe Thrombocytopenia in NeonatesPamela Conley; Fiscal Year: 2006..abstract_text> ..
- EPITHELIAL P2X PURINERGIC RECEPTOR CHANNELSErik Schwiebert; Fiscal Year: 2003..abstract_text> ..
- Nitric oxide in bladder neural-epithelial signalingLori Birder; Fiscal Year: 2005..Elucidation of mechanisms impacting on urothelial function may provide insights into the pathology of bladder dysfunction. ..
- Glial Signaling:Interplay of Connexins and P2 ReceptorsEliana Scemes; Fiscal Year: 2006....
- Regulation of Gliosis by Purinergic Receptor SignalingW Dalton Dietrich; Fiscal Year: 2006..Thus, important advances in the understanding of the mechanisms underlying gliosis may provide new approaches to restore deficits in motor skills and cognitive functions caused by brain injury. [unreadable] [unreadable]..
- NTPDase2 expression and function in the liverJONATHAN DRANOFF; Fiscal Year: 2005..The experiments proposed in these specific aims will provide the basis of several new lines of liver disease research and should provide novel therapeutic targets for treatment of cholestatic and fibrotic liver disease. ..
- EXTRACELLAR NUCLEOTIDE SIGNALING IN CYSTIC FIBROSISErik Schwiebert; Fiscal Year: 2004..We are confident that novel results will be found concerning the cellular and molecular mechanisms of autocrine ATP release, signaling, and regulation of cell volume. ..
- Regulation of Bile Ductular ProliferationJONATHAN DRANOFF; Fiscal Year: 2009..We anticipate that the results of these proposed experiments will lead to novel pharmacologic approaches for the regulation of bile ductular proliferation in biliary cirrhosis. ..
- Identification of a new protein that binds Src and PKCSTEPHEN SOLTOFF; Fiscal Year: 2004..Future efforts will determine if this new protein alters cell morphology, tight junction formation, or other functions in salivary cells. ..
- PARACRINE REGULATION OF BILE DUCT SECRETION BY ATPJONATHAN DRANOFF; Fiscal Year: 2004..The Yale School of Medicine Department of Internal Medicine has pledged that the candidate will have extensive protected research time and excellent resources for the duration of the award. ..
- The function of RhoBTB proteinsSTEPHEN PAUL SOLTOFF; Fiscal Year: 2010..The results of these studies may reveal a new pathway involved in the development of cancer and advance our understanding of the basic biology of transformation. ..
- HEART-LUNG PHYSIOLOGY: MOLECULAR-SYSTEMIC INTEGRATIONWilliam Schilling; Fiscal Year: 2008..Our proposed training program, which emphasizes crossing of departmental barriers and scientific disciplines, continues to develop well-rounded scientists trained in integrated aspects of cardio-respiratory physiology. ..
- PRESYNAPTIC MECHANISMS IN THE INTESTINEJames Galligan; Fiscal Year: 2008..It is also anticipated that these studies will identify new targets for drugs that can be used to treat GI motility disorders. ..
- Characterization of cardiovascular purinoceptorsTERRANCE EGAN; Fiscal Year: 2009..This is important because the receptors may present a new and potentially exciting means of increasing the rate of survival of patients affected by a number of cardiovascular diseases including hypertension and heart failure. ..
- Functional G Protein pathways in platelet activationSatya P Kunapuli; Fiscal Year: 2010..These studies will enhance our understanding of the signaling pathways and their role in platelet activation, and might identify potential newer targets for the treatment of thrombosis. ..
- Mechanisms of antibiotic action in Neisseria gonorrhoeae.Robert A Nicholas; Fiscal Year: 2010..Together, these projects utilize genetic, biochemical, biophysical, and proteomics approaches to generate new insights into the mechanisms of antibiotic action in N. gonorrhoeae. ..
- PURINERGIC AXIS OF CARDIAC BLOOD VESSELSIAIN BUXTON; Fiscal Year: 2001..We will approach these aims with biochemical, pharmacological, molecular, cell biological and microscopic methods employing intact blood vessels, cells in primary culture and subcellular fractions. ..
- Regulation of PMCA Pump-Channels by Oxidant StressWilliam P Schilling; Fiscal Year: 2010..abstract_text> ..
- Trafficking/signaling of P2Y receptors in polarized epithelial cellsRobert A Nicholas; Fiscal Year: 2011..Our studies will provide novel and important information on the cellular mechanisms of P2Y receptor targeting and the regulation of P2Y receptor signaling activity in epithelial cells. ..
- Platelet ADP receptorsSatya Kunapuli; Fiscal Year: 2008..We further propose to evaluate the relative contribution of the P2Y1 and the P2Y12 receptors to thrombus formation, using P2Y1 or P2Y12 deficient mice and treatment with antagonists and models of in vivo thrombosis and thromboembolism. ..
- REGULATION OF PHOSPHOLIPASE CT Harden; Fiscal Year: 2002..Completion of the work described in this proposal should considerably extend knowledge of the identify, specificity, and mechanism of interaction of the component proteins of the receptor-regulated inositol lipid signalling pathway. ..
- Genetic Predictors of Outcome in Acute MIMarc Sabatine; Fiscal Year: 2005..Genomic control will be employed to detect and control for population stratification. Interaction terms will be incorporated into regression models to explore gene-environment and pharmacogenomic interactions. ..
- Vascular tone and blood pressure control during exerciseJohn Buckwalter; Fiscal Year: 2005..This is an issue of fundamental importance that may have important implications for individuals with peripheral vascular disease. ..
- Pediatric Interstitial Lung Disease ConferenceRobin Deterding; Fiscal Year: 2004..Communication between clinical and basic scientists and an enhanced interest in PILD will certainly occur. Ultimately the care of children with these rare diseases will be improved and the field advanced. ..
- Role of Ion Channels in Cell DeathWilliam Schilling; Fiscal Year: 2005..abstract_text> ..
- NUCLEOTIDE-MEDIATED LEUKOCYTE STIMULATIONSatya Kunapuli; Fiscal Year: 2004..The studies proposed in this application will also help us understand the mechanisms of neutrophil activation and contribute to the knowledge of better treatments and to the design of therapeutics for inflammatory diseases. ..
- P2T PURINERGIC RECEPTORSJOSE BOYER; Fiscal Year: 2004..This information should prove useful in the development of new biochemical and pharmacological tools with potential use in the treatment of coagulation-related diseases. ..
- MOLECULAR BIOLOGY OF COLLAGEN RECEPTORSThomas Kunicki; Fiscal Year: 2004..The successful completion of the proposed studies will lead to a substantial increase in our understanding of the genetics and physiology of the platelet collagen receptor, GPVI. ..
- Ap4A as an Alarmone in Stress PhysiologyRICHARD HILDERMAN; Fiscal Year: 2003..The information obtained in this proposal will give us insight on how to develop future proposals, biochemical and molecular experiments to determine the mechanism(s)by which Ap4A acts as an alarmone. ..
- Mechanisms of Nucleotide Release by Airway EpitheliaEduardo Lazarowski; Fiscal Year: 2006..Delineation of nucleotide-releasing mechanisms will provide new possibilities to improve MCC function in chronic lung diseases characterized by mucin-obstructed and inflamed airways. [unreadable] [unreadable]..
- G protein signal integration by multifunctional proteinsT Harden; Fiscal Year: 2006..abstract_text> ..
- Ca2+ channels in non-excitable cellsWilliam Schilling; Fiscal Year: 2006..abstract_text> ..
- Experimental approaches to understanding the ENS and its disordersJames Galligan; Fiscal Year: 2006..This will help the attendees develop a network of professional contacts who can help the young investigator in the career development process. [unreadable] [unreadable]..
- Gating and conduction of ATP-gated ion channelsTERRANCE EGAN; Fiscal Year: 2007..In the second set of experiments, fluorescence resonance energy transfer (FRET) will be used to determine intra- and inter-molecular distances in the absence and presence of ATP. ..
- Molecular Genetics of Integrin Collagen ReceptorsThomas Kunicki; Fiscal Year: 2007..From a clinical standpoint, these studies will also reveal the impact of these gene differences on risk for adverse events in bleeding disorders such as Von Willebrand Disease. ..
- CLEVELAND TRAINING PROGRAM IN CARDIOVASCULAR RESEARCHGEORGE DUBYAK; Fiscal Year: 2008..The proposed renewal will continue to facilitate interaction among faculty and trainees and expand the culture and training excellence in cardiovascular research. ..
- CLASS B SCAVENGER RECEPTORS AND FOAM CELL FORMATIONDENEYS VAN DER WESTHUYZEN; Fiscal Year: 2003..The extent of atherosclerosis will be quantified by lesion size and cholesterol/cholesterol ester content. ..
- Alpha-Synuclein Conditional Knock-in Mice as Novel Models of Parkinson's DiseaseDarren Moore; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- Core Resources for Vision Research at MUSCCraig Crosson; Fiscal Year: 2007..abstract_text> ..
- Adolescents at High Risk for Familial Bipolar DisorderJohn Nurnberger; Fiscal Year: 2009..The ethical implications of this research will be studied by examining the effects of participation and the effect on self-esteem due to high- risk status. ..
- MULTI-PHOTON CONFOCAL MICROSCOPE SYSTEMJanos Peti Peterdi; Fiscal Year: 2008..This multi-photon core is also critically needed for the USC Diabetes Research Center and the Clinical and Translational Science Institute, both being established pending PHS grants. [unreadable] [unreadable] [unreadable]..