atrial natriuretic factor receptors

Summary

Summary: Cell surface proteins that bind ATRIAL NATRIURETIC FACTOR with high affinity and trigger intracellular changes influencing the behavior of cells. They contain intrinsic guanylyl cyclase activity.

Top Publications

  1. pmc Pressure-independent enhancement of cardiac hypertrophy in natriuretic peptide receptor A-deficient mice
    J W Knowles
    Department of Pathology and Laboratory Medicine and Curriculum in Genetics and Molecular Biology, University of North Carolina, Chapel Hill, NC 27599 7525, USA
    J Clin Invest 107:975-84. 2001
  2. pmc Mutations in the transmembrane natriuretic peptide receptor NPR-B impair skeletal growth and cause acromesomelic dysplasia, type Maroteaux
    Cynthia F Bartels
    Department of Genetics, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
    Am J Hum Genet 75:27-34. 2004
  3. pmc The natriuretic peptide clearance receptor locally modulates the physiological effects of the natriuretic peptide system
    N Matsukawa
    Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC 27599 7525, USA
    Proc Natl Acad Sci U S A 96:7403-8. 1999
  4. ncbi Atrial natriuretic peptide gene polymorphisms and risk of ischemic stroke in humans
    Speranza Rubattu
    IRCCS Neuromed, Localita Camerelle, 86077 Pozzilli, Italy
    Stroke 35:814-8. 2004
  5. pmc Three new allelic mouse mutations that cause skeletal overgrowth involve the natriuretic peptide receptor C gene (Npr3)
    J Jaubert
    Unite de Genetique des Mammiferes, Institut Pasteur, 25 rue du Docteur Roux, 75724 Paris Cedex 15, France
    Proc Natl Acad Sci U S A 96:10278-83. 1999
  6. ncbi A loss-of-function mutation in natriuretic peptide receptor 2 (Npr2) gene is responsible for disproportionate dwarfism in cn/cn mouse
    Takehito Tsuji
    Graduate School of Natural Science and Technology, Okayama University, 1 1 1, Tsushima Naka, Okayama 700 8530, Japan
    J Biol Chem 280:14288-92. 2005
  7. pmc Critical roles of the guanylyl cyclase B receptor in endochondral ossification and development of female reproductive organs
    Naohisa Tamura
    Cecil H and Ida Green Center for Reproductive Biology Sciences, Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 101:17300-5. 2004
  8. pmc Phosphorylation of the kinase homology domain is essential for activation of the A-type natriuretic peptide receptor
    L R Potter
    Molecular Biology and Virology Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Mol Cell Biol 18:2164-72. 1998
  9. ncbi Homologous and lysophosphatidic acid-induced desensitization of the atrial natriuretic peptide receptor, guanylyl cyclase-A, in MA-10 leydig cells
    Dieter Muller
    Institute of Anatomy and Cell Biology, Justus Liebig University, Giessen, Germany
    Endocrinology 147:2974-85. 2006
  10. ncbi Down-regulation does not mediate natriuretic peptide-dependent desensitization of natriuretic peptide receptor (NPR)-A or NPR-B: guanylyl cyclase-linked natriuretic peptide receptors do not internalize
    Danhua Fan
    Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, 6 155 Jackson, 321 Church Street S E, Minneapolis, MN 55455, USA
    Mol Pharmacol 67:174-83. 2005

Research Grants

  1. ATRIAL PEPTIDE REGULATION OF SODIUM TRANSPORT
    Mark Zeidel; Fiscal Year: 1990
  2. ANP RECEPTOR-MEDIATED OF FUNCTIONS IN GLOMERULAR CELLS
    BARBARA BALLERMANN; Fiscal Year: 1992
  3. Role of Natriuretic Peptides in the Cochlea
    George Trachte; Fiscal Year: 2004
  4. NEW APPROACH TO ENDOTHELIAL CLEFT STRUCTURE
    Fitz Roy E Curry; Fiscal Year: 2010
  5. IMPROVEMENT OF MEMBRANE BIOLOGY FACILITY
    FITZ ROY CURRY; Fiscal Year: 2002
  6. REGULATION OF ANP RECEPTOR ACTIVITY IN VASCULAR CELLS
    David G Gardner; Fiscal Year: 2011
  7. cAMP Phosphodiesterase and Lung Endothelial Cell Permeability
    Thomas C Rich; Fiscal Year: 2010
  8. Intestinal Peptides Involved in Volume Homeostasis
    MICHAEL GOY; Fiscal Year: 2009
  9. Cyclic AMP signaling in cardiac myocytes
    THOMAS RICH; Fiscal Year: 2007
  10. GENETICS OF HEART AND KIDNEY DAMAGE IN HYPERTENSION
    Christian Deschepper; Fiscal Year: 2004

Detail Information

Publications174 found, 100 shown here

  1. pmc Pressure-independent enhancement of cardiac hypertrophy in natriuretic peptide receptor A-deficient mice
    J W Knowles
    Department of Pathology and Laboratory Medicine and Curriculum in Genetics and Molecular Biology, University of North Carolina, Chapel Hill, NC 27599 7525, USA
    J Clin Invest 107:975-84. 2001
    ..Taken together, these results suggest that the NPRA system has direct antihypertrophic actions in the heart, independent of its role in BP control...
  2. pmc Mutations in the transmembrane natriuretic peptide receptor NPR-B impair skeletal growth and cause acromesomelic dysplasia, type Maroteaux
    Cynthia F Bartels
    Department of Genetics, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
    Am J Hum Genet 75:27-34. 2004
    ..We conclude that, although NPR-B is expressed in a number of tissues, its major role is in the regulation of skeletal growth...
  3. pmc The natriuretic peptide clearance receptor locally modulates the physiological effects of the natriuretic peptide system
    N Matsukawa
    Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC 27599 7525, USA
    Proc Natl Acad Sci U S A 96:7403-8. 1999
    ..We conclude that NPRC modulates the availability of the natriuretic peptides at their target organs, thereby allowing the activity of the natriuretic peptide system to be tailored to specific local needs...
  4. ncbi Atrial natriuretic peptide gene polymorphisms and risk of ischemic stroke in humans
    Speranza Rubattu
    IRCCS Neuromed, Localita Camerelle, 86077 Pozzilli, Italy
    Stroke 35:814-8. 2004
    ..The purpose of the present study was to investigate the contributory role of the genes encoding atrial natriuretic peptide (ANP) and type A natriuretic peptide receptor (NPRA) in humans' susceptibility to develop ischemic stroke...
  5. pmc Three new allelic mouse mutations that cause skeletal overgrowth involve the natriuretic peptide receptor C gene (Npr3)
    J Jaubert
    Unite de Genetique des Mammiferes, Institut Pasteur, 25 rue du Docteur Roux, 75724 Paris Cedex 15, France
    Proc Natl Acad Sci U S A 96:10278-83. 1999
    ....
  6. ncbi A loss-of-function mutation in natriuretic peptide receptor 2 (Npr2) gene is responsible for disproportionate dwarfism in cn/cn mouse
    Takehito Tsuji
    Graduate School of Natural Science and Technology, Okayama University, 1 1 1, Tsushima Naka, Okayama 700 8530, Japan
    J Biol Chem 280:14288-92. 2005
    ....
  7. pmc Critical roles of the guanylyl cyclase B receptor in endochondral ossification and development of female reproductive organs
    Naohisa Tamura
    Cecil H and Ida Green Center for Reproductive Biology Sciences, Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 101:17300-5. 2004
    ..This result was due to the failure of the female reproductive tract to develop. Thus, the guanylyl cyclase B receptor is critical for the development of both bone and female reproductive organs...
  8. pmc Phosphorylation of the kinase homology domain is essential for activation of the A-type natriuretic peptide receptor
    L R Potter
    Molecular Biology and Virology Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Mol Cell Biol 18:2164-72. 1998
    ..We conclude that phosphorylation of the KHD is absolutely required for hormone-dependent activation of NPR-A...
  9. ncbi Homologous and lysophosphatidic acid-induced desensitization of the atrial natriuretic peptide receptor, guanylyl cyclase-A, in MA-10 leydig cells
    Dieter Muller
    Institute of Anatomy and Cell Biology, Justus Liebig University, Giessen, Germany
    Endocrinology 147:2974-85. 2006
    ..The morphoregulatory activities exerted by LPA suggest a crucial role for Leydig cell physiology...
  10. ncbi Down-regulation does not mediate natriuretic peptide-dependent desensitization of natriuretic peptide receptor (NPR)-A or NPR-B: guanylyl cyclase-linked natriuretic peptide receptors do not internalize
    Danhua Fan
    Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, 6 155 Jackson, 321 Church Street S E, Minneapolis, MN 55455, USA
    Mol Pharmacol 67:174-83. 2005
    ..We suggest that mechanisms other than receptor down-regulation account for the desensitization of NPR-A and NPR-B that occurs in response to various physiological and pathological stimuli...
  11. pmc Hypertension, cardiac hypertrophy, and sudden death in mice lacking natriuretic peptide receptor A
    P M Oliver
    Department of Pathology, University of North Carolina, 710 Brinkhous Bullitt Building, Chapel Hill, NC 27599 7525, USA
    Proc Natl Acad Sci U S A 94:14730-5. 1997
    ..Thus complete absence of NPRA causes hypertension in mice and leads to cardiac hypertrophy and, particularly in males, lethal vascular events similar to those seen in untreated human hypertensive patients...
  12. ncbi The atrial natriuretic peptide receptor (NPR-A/GC-A) is dephosphorylated by distinct microcystin-sensitive and magnesium-dependent protein phosphatases
    Paula M Bryan
    Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, St Paul, Minnesota 55108, USA
    J Biol Chem 277:16041-7. 2002
    ..Finally, we observed that the desensitization of NPR-A in membranes from mouse kidneys and NIH3T3 cells was increased by prior exposure to atrial natriuretic peptide, suggesting that hormone binding enhances receptor dephosphorylation...
  13. pmc Vascular natriuretic peptide receptor-linked particulate guanylate cyclases are modulated by nitric oxide-cyclic GMP signalling
    Melanie Madhani
    Wolfson Institute for Biomedical Research, University College London, Cruciform Building, Gower Street, London WC1E 6AE
    Br J Pharmacol 139:1289-96. 2003
    ....
  14. ncbi Guanylyl cyclase-A inhibits angiotensin II type 1A receptor-mediated cardiac remodeling, an endogenous protective mechanism in the heart
    Yuhao Li
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Circulation 106:1722-8. 2002
    ..We investigated whether GC-A interacts with AT1A signaling in the heart by target deletion and pharmacological blockade or stimulation of AT1A in mice...
  15. pmc Pressure-independent cardiac hypertrophy in mice with cardiomyocyte-restricted inactivation of the atrial natriuretic peptide receptor guanylyl cyclase-A
    Rita Holtwick
    Institut fur Pharmakologie und Toxikologie, Universitatsklinikum Munster, Munster, Germany
    J Clin Invest 111:1399-407. 2003
    ..This phenotype is consistent with a local function of the ANP/GC-A system to moderate the molecular program of cardiac hypertrophy...
  16. ncbi Crystal structure of hormone-bound atrial natriuretic peptide receptor extracellular domain: rotation mechanism for transmembrane signal transduction
    Haruo Ogawa
    Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    J Biol Chem 279:28625-31. 2004
    ..These results suggest that transmembrane signaling by the ANP receptor is initiated via a hormone-induced rotation mechanism...
  17. ncbi Atrial natriuretic peptide polarizes human dendritic cells toward a Th2-promoting phenotype through its receptor guanylyl cyclase-coupled receptor A
    Rimpei Morita
    Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    J Immunol 170:5869-75. 2003
    ..These results indicate that ANP polarizes human DCs toward a Th2-promoting phenotype through GC-A and thus can regulate immune responses...
  18. ncbi Enhanced activity of the myocardial Na+/H+ exchanger NHE-1 contributes to cardiac remodeling in atrial natriuretic peptide receptor-deficient mice
    Ana Kilic
    Institute of Physiology, University of Wurzburg, Wurzburg, Germany
    Circulation 112:2307-17. 2005
    ..The mechanisms underlying the antihypertrophic effects of ANP remain largely uncharacterized. We examined the contribution of the Na+/H+ exchanger NHE-1 to cardiac remodeling in GC-A-deficient (GC-A(-/-)) mice...
  19. ncbi Identification and characterization of the phosphorylation sites of the guanylyl cyclase-linked natriuretic peptide receptors A and B
    L R Potter
    Molecular Biology and Virology Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California, 92037, USA
    Methods 19:506-20. 1999
    ..In this review, we give a detailed description of the phosphopeptide mapping techniques that were used to identify and characterize these sites and discuss the potential pitfalls that are associated with them...
  20. ncbi Structure, regulation, and function of mammalian membrane guanylyl cyclase receptors, with a focus on guanylyl cyclase-A
    Michaela Kuhn
    Institute of Pharmacology and Toxicology, Universitatsklinikum Munster, Domagkstrasse 12, D 48149 Munster, Germany
    Circ Res 93:700-9. 2003
    ....
  21. ncbi Natriuretic peptide signalling: molecular and cellular pathways to growth regulation
    M Silberbach
    Division of Pediatric Cardiology, Department of Pediatrics, Doernbecher Children s Hospital, UHN 60, 3181 SW Sam Jackson Park Road, 97201, Portland, OR, USA
    Cell Signal 13:221-31. 2001
    ..The inhibition of cardiac growth and hypertrophy may be an important but underappreciated action of the NP signalling system...
  22. ncbi Receptor selectivity of natriuretic peptide family, atrial natriuretic peptide, brain natriuretic peptide, and C-type natriuretic peptide
    S Suga
    Department of Medicine, Kyoto University School of Medicine, Japan
    Endocrinology 130:229-39. 1992
    ..These findings on the receptor selectivity of the natriuretic peptide family provide a new insight into the understanding of the physiological and clinical implications of the natriuretic peptide system...
  23. pmc Alternative splicing of the guanylyl cyclase-A receptor modulates atrial natriuretic peptide signaling
    Michael Hartmann
    Institute of Physiology, University of Wurzburg, D 97070 Wurzburg, Germany
    J Biol Chem 283:28313-20. 2008
    ..We conclude that alternative splicing can regulate endogenous ANP/GC-A signaling. Angiotensin II-induced alternative splicing of GC-A may represent a novel mechanism for reducing the sensitivity to ANP...
  24. ncbi Natriuretic peptide receptor a as a novel anticancer target
    Xiaoyuan Kong
    Joy McCann Culverhouse Airway Disease and Nanomedicine Research Center, Allergy and Immunology Division, Department of Internal Medicine, University of South Florida College of Medicine, Tampa, FL 33612, USA
    Cancer Res 68:249-56. 2008
    ..These results suggest that NPRA is involved in tumor angiogenesis and represents a new target for cancer therapy...
  25. ncbi A membrane form of guanylate cyclase is an atrial natriuretic peptide receptor
    M Chinkers
    Howard Hughes Medical Institute, Vanderbilt University School of Medicine, Nashville, Tennessee 37232
    Nature 338:78-83. 1989
    ..The ANP receptor/guanylate cyclase represents a new class of mammalian cell-surface receptors which contain an extracellular ligand-binding domain and an intracellular guanylate cyclase catalytic domain...
  26. pmc Regulation of natriuretic peptide receptor-A gene expression and stimulation of its guanylate cyclase activity by transcription factor Ets-1
    Prerna Kumar
    Department of Physiology, Tulane University Health Sciences Center, School of Medicine, New Orleans, LA 70112, U S A
    Biosci Rep 29:57-70. 2009
    ..Collectively, the present study demonstrates that Npr1 gene transcription and GC activity of the receptor are critically controlled by Ets-1 in target cells...
  27. ncbi Natriuretic peptides suppress vascular endothelial cell growth factor signaling to angiogenesis
    A Pedram
    Division of Endocrinology, Veterans Affairs Medical Center, Long Beach, California 90822, USA
    Endocrinology 142:1578-86. 2001
    ..The actions are significantly prevented by NP, which act through both the NPRC and GC receptors to block growth factor signaling. Thus, NP are candidate antiangiogenesis factors that inhibit both the synthesis and function of VEGF...
  28. ncbi The primary structure of a plasma membrane guanylate cyclase demonstrates diversity within this new receptor family
    S Schulz
    Howard Hughes Medical Institute, Vanderbilt University Medical Center, Nashville, Tennessee 37232
    Cell 58:1155-62. 1989
    ....
  29. ncbi Modulation by brain natriuretic peptide of GABA receptors on rat retinal ON-type bipolar cells
    Yong Chun Yu
    Institute of Neurobiology, Fudan University, Shanghai 200433, China
    J Neurosci 26:696-707. 2006
    ..We therefore conclude that the increased calcium release from ryanodine-sensitive calcium stores by BNP may be responsible for the BNP-caused GABAA response suppression in ON-type BCs through stimulating calmodulin...
  30. ncbi Natriuretic peptide system in the human retina
    Raquel Rollin
    Unidad de Investigacion, Departamento de Medicina Interna III, Hospital Clinico San Carlos, Madrid, Spain
    Mol Vis 10:15-22. 2004
    ..The expression pattern of the genes encoding the different NP receptor subtypes was also examined...
  31. ncbi CNP-induced changes in pHi, cGMP/cAMP and mRNA expression of natriuretic peptide receptors in human trabecular meshwork cells
    Lichun Zhong
    Morehouse School of Medicine, Atlanta, GA 30310, USA
    J Ocul Pharmacol Ther 19:425-36. 2003
    ..CNP activates NPR-B receptors preferentially to increase cGMP accumulation and acts through the PTX-sensitive cAMP-signaling pathway leading to a decrease in pH(i)...
  32. ncbi Increased sensitivity to endothelial nitric oxide (NO) contributes to arterial normotension in mice with vascular smooth muscle-selective deletion of the atrial natriuretic peptide (ANP) receptor
    Karim Sabrane
    Institute of Pharmacology and Toxicology, Universitatsklinikum Munster, D 48149 Munster, Germany
    J Biol Chem 278:17963-8. 2003
    ..Increased vasodilating responsiveness to endothelial NO contributes to compensate for the missing vasodilating effect of ANP in SMC GC-A KO mice...
  33. ncbi Structure of the atrial natriuretic peptide receptor extracellular domain in the unbound and hormone-bound states by single-particle electron microscopy
    Haruo Ogawa
    Department of Biochemistry, University of Nevada, Reno, NV 89557, USA
    FEBS J 276:1347-55. 2009
    ..The results also support the proposed rotation mechanism for transmembrane signaling by the ANP receptor...
  34. ncbi Natriuretic peptides as regulatory mediators of secretory activity in the digestive system
    Maria Eugenia Sabbatini
    Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109 5622, United States
    Regul Pept 154:5-15. 2009
    ..Overall, these findings indicate that ANP and CNP are members of the large group of regulatory peptides affecting digestive secretions...
  35. pmc Expression, purification, and characterization of the intra-cellular domain of the ANP receptor
    Priyaranjan Pattanaik
    Department of Biochemistry RT500, Case Western Reserve University, 10900 Euclid Av, Cleveland, OH 44106, USA
    Biochimie 91:888-93. 2009
    ..These receptor insights could aid in the development of novel therapeutics as the GCA receptor is a key drug target for cardiovascular diseases...
  36. pmc Reciprocal regulation of human soluble and particulate guanylate cyclases in vivo
    M Madhani
    Wolfson Institute for Biomedical Research, University College London, London, UK
    Br J Pharmacol 149:797-801. 2006
    ..Herein, we investigated whether such an interaction contributes to vascular homeostasis in mice and humans in vivo...
  37. ncbi The receptor attributable to C-type natriuretic peptide-induced differentiation of osteoblasts is switched from type B- to type C-natriuretic peptide receptor with aging
    Hiroyuki Kaneki
    Faculty of Pharmaceutical Sciences, Toho University, Miyama 2 2 1, Funabashi, Chiba 274 8510, Japan
    J Cell Biochem 103:753-64. 2008
    ..From these results, we concluded that CNP acts as a positive regulator of bone formation by osteoblasts and that the signaling pathway for CNP is switched from NPR-B/cGMP/PKG to NPR-C/G(i) protein/PLC with aging...
  38. ncbi Role of extracellular domain dimerization in agonist-induced activation of natriuretic peptide receptor A
    Marie Parat
    Department of Pharmacology, Faculty of Medicine, Universite de Montreal, 2900 boulevardEdouard Montpetit, Pavillon Principal, V437 1, Montreal, QC, Canada
    Mol Pharmacol 73:431-40. 2008
    ..Furthermore, the highly sensitive fluorescence assay designed to assess dimerization could serve as a powerful tool for further detailing the kinetic steps involved in natriuretic peptide receptor binding and activation...
  39. ncbi Allosteric activation of a spring-loaded natriuretic peptide receptor dimer by hormone
    - He Xl
    Departments of Microbiology and Immunology and Structural Biology, Stanford University School of Medicine, Fairchild D319, 299 Campus Drive, Stanford, CA 93405 5124, USA
    Science 293:1657-62. 2001
    ..In each monomer, the opening of an interdomain cleft, which is tethered together by a linker peptide acting as a molecular spring, is likely a conserved allosteric trigger for intracellular signaling by the natriuretic receptor family...
  40. ncbi Role of atrial natriuretic peptide in pulmonary permeability and vasoregulation in ovine sepsis
    Henning D Stubbe
    Klinik und Poliklinik für Anästhesiologie und operative Intensivmedizin, Universitatsklinikum Munster, Germany
    Crit Care Med 32:2491-5. 2004
    ..Atrial natriuretic peptide is regarded as an important regulator of pulmonary vasomotor tone and permeability. This study investigated the role of atrial natriuretic peptide in sepsis-associated pulmonary pathophysiology...
  41. ncbi C-type natriuretic peptide and guanylyl cyclase B receptor
    Stephanie Schulz
    Division of Clinical Pharmacology, Department of Medicine and Biochemistry, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Peptides 26:1024-34. 2005
    ..This review will examine the structure and function of GC-B, and summarize the physiological processes in which this receptor is thought to participate...
  42. ncbi Autocrine and paracrine actions of natriuretic peptides in the heart
    Savio P D'Souza
    The Heart Hospital, London, UK
    Pharmacol Ther 101:113-29. 2004
    ..Ultimately, insights from the autocrine/paracrine actions of natriuretic peptides may provide routes to therapeutic application in cardiac diseases of natriuretic peptides and drugs that modify their availability...
  43. ncbi Missense mutation of exon 3 in the type A human natriuretic peptide receptor gene is associated with myocardial infarction
    Tomohiro Nakayama
    2nd Department of Internal Medicine, Nihon Medical University, Itabashi ku, Tokyo, Japan
    Med Sci Monit 9:CR505-10. 2003
    ..This mutation is associated with increased risk for essential hypertension (EH). The purpose of this study was to investigate association between MI and the M341I mutation in the hNPRA gene...
  44. ncbi Natriuretic peptides inhibit rat astroglial proliferation: mediation by C receptor
    E R Levin
    Department of Medicine, University of California, Irvine 92717
    Am J Physiol 261:R453-7. 1991
    ..The inhibitory effects are not the result of inhibiting the proliferative effects of an endogenous growth factor and are cAMP independent...
  45. ncbi A novel missense mutation of exon 3 in the type A human natriuretic peptide receptor gene: possible association with essential hypertension
    Tomohiro Nakayama
    Division of Receptor Biology, Advanced Medical Research Center, Tokyo, Japan
    Hypertens Res 25:395-401. 2002
    ..We conclude that the significance of homozygous M3411 mutation in exon 3 is worth investigating for its possible association with EH...
  46. ncbi Molecular physiology of natriuretic peptide signalling
    Michaela Kuhn
    Institute of Pharmacology and Toxicology, Universitatsklinikum Munster, Domagkstrasse 12, Munster 48149, Germany
    Basic Res Cardiol 99:76-82. 2004
    ....
  47. ncbi Embryonic expression and multifunctional actions of the natriuretic peptides and receptors in the developing nervous system
    E Dicicco-Bloom
    Department of Neuroscience and Cell Biology, University of Medicine, Piscataway, NJ 08854, USA
    Dev Biol 271:161-75. 2004
    ....
  48. ncbi Salt-resistant hypertension in mice lacking the guanylyl cyclase-A receptor for atrial natriuretic peptide
    M J Lopez
    Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas 75235 9050, USA
    Nature 378:65-8. 1995
    ....
  49. ncbi Atrial natriuretic peptide contributes to physiological control of lipid mobilization in humans
    Cedric Moro
    Unité de Recherches sur les Obésités, Institut National de la Santé et de la Recherche Médicale U586, Toulouse, France
    FASEB J 18:908-10. 2004
    ..Oral beta-adrenergic receptor blockade, which potentiates exercise-induced ANP release by the heart, may contribute to lipid mobilization in SCAT. The potential relevance of an ANP-related lipid-mobilizing pathway is discussed...
  50. ncbi Role of cyclic GMP and calcineurin in homologous and heterologous desensitization of natriuretic peptide receptor-A
    Yann Fortin
    Departement de Pharmacologie, Faculte de Medecine, Universite de Montreal, 2900 boul Edouard Montpetit, Pavillon Principal, V 437 1, Montreal, QC H3T 1J4, Canada
    Can J Physiol Pharmacol 84:539-46. 2006
    ..Our results also indicate for the first time a role for calcineurin in NPR-A heterologous desensitization...
  51. ncbi C-type natriuretic Peptide down-regulates expression of its cognate receptor in rat aortic smooth muscle cells
    Dolkun Rahmutula
    Department of Medicine and Diabetes Center, 1109 HSW, University of California at San Francisco, San Francisco, California 94143 0540, USA
    Endocrinology 146:4968-74. 2005
    ..This report provides the first documentation that CNP is capable of autoregulating the expression of its cognate receptor...
  52. ncbi Four peptide hormones decrease the number of human breast adenocarcinoma cells
    B A Vesely
    Department of Biochemistry and Molecular Biology, University of South Florida Cardiac Hormone Center and James A Haley Veteran s Administration Medical Center, Tampa, FL, USA
    Eur J Clin Invest 35:60-9. 2005
    ....
  53. ncbi Characterization of a cGMP-response element in the guanylyl cyclase/natriuretic peptide receptor A gene promoter
    David Hum
    Centre de Recherche, Centre Hospitalier de l Universite de Montreal Hotel Dieu, Montreal, Quebec, Canada
    Hypertension 43:1270-8. 2004
    ....
  54. ncbi Natriuretic peptide receptor A mediates renal sodium excretory responses to blood volume expansion
    Shang Jin Shi
    Department of Physiology, Tulane University Health Sciences Center School of Medicine, New Orleans, LA 70112, USA
    Am J Physiol Renal Physiol 285:F694-702. 2003
    ..01) and RPF (P < 0.01) compared with 2-copy wild-type mice. These results establish that NPRA activation is the predominant mechanism mediating the natriuretic, diuretic, and renal hemodynamic responses to acute blood volume expansion...
  55. ncbi Postnatal ontogeny of natriuretic peptide systems in the rat hypothalamus
    Marek Jankowski
    Centre de Recherche, Centre Hospitalier de l Universite de Montreal Hotel Dieu, Pavillon de Bullion, 3850 Rue Saint Urbain, Montreal, Quebec H2W 1T7, Canada
    Brain Res Dev Brain Res 152:39-46. 2004
    ..In conclusion, we have shown that hypothalamic ANP undergoes a dramatic rise after birth, and progresses further until the 3rd postnatal week. ANP and CNP changes in the developing hypothalamus can influence brain maturation...
  56. ncbi Atrial natriuretic peptide induces mitogen-activated protein kinase phosphatase-1 in human endothelial cells via Rac1 and NAD(P)H oxidase/Nox2-activation
    Robert Fürst
    Department of Pharmacy, University of Munich, Germany
    Circ Res 96:43-53. 2005
    ..In summary, our work provides insights into the mechanisms by which ANP induces MKP-1 and shows that ANP is a novel endogenous activator of endothelial Rac1 and Nox/Nox2...
  57. ncbi [Vasonatrin peptide attenuates the enhancement of electrically-induced intracellular calcium transient by isoproterenol in rat cardiac myocytes]
    Hai Tao Guo
    Department of Physioloy, Fourth Military Medical University, Xi an 710032 China
    Sheng Li Xue Bao 56:335-40. 2004
    ..These results suggest that VNP attenuates [Ca(2+)](i) transient induced by Iso. This effect is possibly achieved by binding VNP with the natriuretic peptide GC receptors in the myocytes, leading to an increase in intracellular cGMP...
  58. ncbi Cyclic adenosine monophosphate (cAMP) increases natriuretic peptide receptor C (NPR-C) expression in human aortic smooth muscle cells
    E Puggina
    Department of Medicine, Division of Endocrinology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, A3060 Bethesda, MD 20814 4799, USA
    Mol Cell Endocrinol 219:161-9. 2004
    ..125 mM dbcAMP. The present data suggest that elevation of cAMP in human vascular smooth muscle may potentiate the vasoactive effects of natriuretic peptides acting through the NPR-B and NPR-C receptors...
  59. ncbi Kupffer-cell specific induction of heme oxygenase 1 (hsp32) by the atrial natriuretic peptide--role of cGMP
    Alexandra K Kiemer
    Department of Pharmacy, Center of Drug Research, University of Munich, Munich, Germany
    J Hepatol 38:490-8. 2003
    ..Heme oxygenase-1 (HO-1) is known as a protective mediator in ischemia-reperfusion injury. The aim of this study was to investigate whether ANP affects the expression of HO-1...
  60. ncbi Cyclic GMP-specific phosphodiesterase 5 regulates growth and apoptosis in pulmonary endothelial cells
    Bing Zhu
    Dept of Pharmacology, Center for Lung Biology, Univ of So Alabama College of Medicine, CSAB 345, 301 N Univ Blvd, Mobile, AL 36688, USA
    Am J Physiol Lung Cell Mol Physiol 289:L196-206. 2005
    ..Collectively, these data suggest that PDE5-regulated [cGMP]i controls endothelial cell growth and apoptosis, representing a mechanism of heterogeneity between two endothelial phenotypes...
  61. ncbi Cardiac-specific attenuation of natriuretic peptide A receptor activity accentuates adverse cardiac remodeling and mortality in response to pressure overload
    Jeetendra B Patel
    Cardiorenal Research Laboratory, Guggenheim 9, Mayo Clinic, 200 First St, Southwest, Rochester, MN 55905, USA
    Am J Physiol Heart Circ Physiol 289:H777-84. 2005
    ....
  62. ncbi Ouabain-insensitive Na+-ATPase of proximal tubules is an effector for urodilatin and atrial natriuretic peptide
    C Caruso-Neves
    Instituto de Biofisica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, CCS Bloco G, 21949 900 Rio de Janeiro, RJ, Brazil
    Biochim Biophys Acta 1660:93-8. 2004
    ..The data obtained indicate that this effect is mediated by the activation of the NPR-A/guanylate cyclase/cGMP pathway...
  63. ncbi Dendroaspis natriuretic peptide and its functions in pig ovarian granulosa cells
    Feng Lian Piao
    Department of Physiology, Medical School, Institute for Medical Sciences, Chonbuk National University, 2 20 Keum Am Dong San, Jeonju 560 181, South Korea
    Regul Pept 118:193-8. 2004
    ..Increases in production of cGMP in granulosa cells were observed by DNP or CNP. Therefore, these results show the existence of DNP system and the cross-talk between natriuretic peptides in pig ovarian granulosa cells...
  64. ncbi Spatiotemporal regulation of the two atrial natriuretic peptide receptors in testis
    Dieter Muller
    Institute for Hormone and Fertility Research, University of Hamburg, 22529 Hamburg, Germany
    Endocrinology 145:1392-401. 2004
    ....
  65. ncbi NPR-C receptors are involved in C-type natriuretic peptide response on bile secretion
    Maria E Sabbatini
    Cátedra de Fisiopatologi a, Facultad de Farmacia y Bioqui mica, Universidad de Buenos Aires, Juni n 956, 5 piso 1113, Buenos Aires, Argentina
    Regul Pept 116:13-20. 2003
    ..The present study shows that CNP modulates bile secretion in the rat, suggesting that CNP may be part of the large family of peptides involved in the regulation of gastrointestinal physiology...
  66. ncbi Left ventricular assist device support reverses altered cardiac expression and function of natriuretic peptides and receptors in end-stage heart failure
    Michaela Kuhn
    Institute of Pharmacology and Toxicology and Interdisciplinary Center for Clinical Research, Universitatsklinikum Munster, Domagkstrasse 12, D 48129 Munster, Germany
    Cardiovasc Res 64:308-14. 2004
    ....
  67. ncbi Down-regulation of C-type natriuretic peptide receptor by vasonatrin peptide in cardiac myocytes and fibroblasts
    Shun Yan Lu
    Department of Physiology, Fourth Military Medical University, Xi an 710032, China
    Acta Pharmacol Sin 25:424-30. 2004
    ..To investigate the regulatory effects of vasonatrin peptide (VNP) on the expression of C-type natriuretic peptide receptor (NPR-C) in cultured neonatal rat cardiac myocytes and fibroblasts...
  68. ncbi Diverging vasorelaxing effects of C-type natriuretic peptide in renal resistance arteries and aortas of GC-A-deficient mice
    Martin Steinmetz
    Medizinische Klinik und Poliklinik D, Universitatsklinikum Munster, Albert Schweitzer Strasse 33, 48129 Munster, Germany
    Regul Pept 119:31-7. 2004
    ..Changes at the GC-B receptor level are likely to explain the diminished responsiveness of GC-A-deficient RRA to CNP...
  69. ncbi Increased susceptibility to heart failure in response to volume overload in mice lacking natriuretic peptide receptor-A gene
    Toshio Nishikimi
    Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7525, USA
    Cardiovasc Res 66:94-103. 2005
    ..Contribution of the natriuretic peptide system to the development of heart failure (HF) in vivo was examined using mice lacking or having decreased natriuretic peptide receptor-A (NPRA), a guanylyl cyclase-linked receptor...
  70. ncbi C-type natriuretic peptide as a podocyte hormone and modulation of its cGMP production by glucose and mechanical stress
    Barbara Lewko
    Department of Immunopathology, Medical University of Gdansk, Gdansk, Poland
    Kidney Int 66:1001-8. 2004
    ..We investigated whether mechanical stress and high ambient glucose influence cGMP generation in podocytes stimulated with NPs. Additionally, the C-type natriuretic peptide (CNP) system has been characterized in these cells...
  71. ncbi Natriuretic peptides inhibit adenylyl cyclase activity in dispersed eel gill cells
    W Callahan
    School of Biological and Chemical Sciences, Deakin University, VIC 3217, 3217, Geelong, Vic, Australia
    J Comp Physiol B 174:275-80. 2004
    ..BBXXB (B = basic, X = nonbasic residues). These data suggest that branchially-expressed NPR-C may play a physiological role additional to that of ligand clearance...
  72. ncbi Antihypertrophic actions of the natriuretic peptides in adult rat cardiomyocytes: importance of cyclic GMP
    Anke C Rosenkranz
    Howard Florey Institute, C The University of Melbourne, Parkville, VIC 3010, Australia
    Cardiovasc Res 57:515-22. 2003
    ..However, whether this effect is retained in the adult phenotype or if other members of the natriuretic peptide family exhibit similar antihypertrophic properties, has not been elucidated...
  73. ncbi Calcineurin-nuclear factor of activated T cells pathway-dependent cardiac remodeling in mice deficient in guanylyl cyclase A, a receptor for atrial and brain natriuretic peptides
    Takeshi Tokudome
    Department of Biochemistry, Research Institute, National Cardiovascular Center, Suita, Osaka, Japan
    Circulation 111:3095-104. 2005
    ..In this study, we examined the role of calcineurin, a calcium-dependent phosphatase, in cardiac remodeling in GCA-knockout (GCA-KO) mice...
  74. ncbi Heart specific up-regulation of genes for B-type and C-type natriuretic peptide receptors in diabetic mice
    C Christoffersen
    Department of Biochemistry, Rigshospitalet, University of Copenhagen, Denmark
    Eur J Clin Invest 36:69-75. 2006
    ..The role of NP type-C (CNP) and NPR type-B (NPR-B) in the heart is less well established. In this study we examined if diabetes alters heart expression of the genes encoding the NP and its receptors...
  75. pmc Evidence for a novel natriuretic peptide receptor that prefers brain natriuretic peptide over atrial natriuretic peptide
    M F Goy
    Departments of Cell and Molecular Physiology, University of North Carolina, Box 7545, Chapel Hill, NC 27599, USA
    Biochem J 358:379-87. 2001
    ..This residual response to BNP cannot be accounted for by natriuretic peptide receptor B, or any other known mammalian rGC, suggesting the presence of a novel receptor in these tissues that prefers BNP over ANP...
  76. ncbi Regulation of ANP clearance receptors by EGF in mesangial cells from NOD mice
    S Placier
    , , 75020 Paris, France
    Am J Physiol Renal Physiol 281:F244-54. 2001
    ..These studies suggest that EGF potentiates the ANP glomerular effects in diabetes by inhibition of its degradation by mesangial NPR-C via a mechanism involving AP-1...
  77. pmc Differential gene expression of the three natriuretic peptides and natriuretic peptide receptor subtypes in human liver
    A M Vollmar
    Institute of Pharmacology, Toxicology and Pharmacy, Ludwigs Maximilians University of Munich, Germany
    Gut 40:145-50. 1997
    ..Various effects of atrial natriuretic peptide (ANP) on the liver have been observed. However, there is limited information about the types of receptors for natriuretic peptides expressed by the human liver...
  78. ncbi Differential expression and synthesis of natriuretic peptides determines natriuretic peptide receptor expression in primary cultures of human proximal tubular cells
    S K Mistry
    Department of Medicine and Therapeutics, Aberdeen University Medical School, Foresterhill, UK
    J Hypertens 19:255-62. 2001
    ....
  79. pmc Natriuretic peptides and nitric oxide stimulate cGMP synthesis in different cellular compartments
    Leslie A Piggott
    Program in Cell and Regulatory Biology, The University of Texas Graduate School of Biomedical Sciences at Houston, 77225, USA
    J Gen Physiol 128:3-14. 2006
    ..These results suggest that cGMP signals are spatially segregated within cells, and that the functional compartmentalization of cGMP signals may underlie the unique actions of ANP and nitric oxide...
  80. ncbi Mesangial cells from diabetic NOD mice constitutively express increased density of atrial natriuretic peptide C receptors
    N Ardaillou
    Hopital Tenon, Paris, France
    Kidney Int 55:1293-302. 1999
    ..Experimental evidence shows that natriuretic peptides (NPs) play a pathophysiological role in the glomerular hemodynamic abnormalities that occur in diabetes mellitus...
  81. ncbi Signaling pathways involved in atrial natriuretic factor and dopamine regulation of renal Na+, K+ -ATPase activity
    Alicia H Correa
    Cátedras de Fisiopatología, Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires, IQUIFIB CONICET, Junín 956 piso 5, 1113 Buenos Aires, Argentina
    Regul Pept 138:26-31. 2007
    ..This mechanism demonstrates a DA-ANF relationship involved in the modulation of both decreased sodium reabsorption and increased natriuresis...
  82. ncbi Differential regulation of membrane guanylyl cyclases in congestive heart failure: natriuretic peptide receptor (NPR)-B, Not NPR-A, is the predominant natriuretic peptide receptor in the failing heart
    Deborah M Dickey
    University of Minnesota, Department of Biochemistry, Molecular Biology, and Biophysics, 6 155 Jackson Hall, 321 Church Street Southeast, Minneapolis, Minnesota 55455, USA
    Endocrinology 148:3518-22. 2007
    ..Based on these findings, we suggest that drugs that target both NPRs may be more beneficial than drugs like nesiritide (Natrecor) that target NPR-A alone...
  83. ncbi The guanylyl cyclase-deficient mouse defines differential pathways of natriuretic peptide signaling
    M J Lopez
    Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas 75235 9050, USA
    J Biol Chem 272:23064-8. 1997
    ..Thus, two natriuretic peptides (ANP, BNP) act through GC-A whereas another (CNP) acts through another receptor to regulate blood pressure...
  84. ncbi Vitamin D activates type A natriuretic peptide receptor gene transcription in inner medullary collecting duct cells
    S Chen
    Diabetes Center, University of California at San Francisco, San Francisco, California 94143 0540, USA
    Kidney Int 72:300-6. 2007
    ..The increase in this receptor expression may account for some of the reported beneficial effect of 1,25(OH)(2)D3 on the cardiovascular system and kidney...
  85. ncbi Characterization of C-type natriuretic peptide receptors in human mesangial cells
    J Zhao
    INSERM 64, Hopital Tenon, Paris, France
    Kidney Int 46:717-25. 1994
    ..ANPR-A, ANPR-B and ANPR-C mRNA were present in epithelial cells whereas only ANPR-B and ANPR-C mRNA were detected in mesangial cells.(ABSTRACT TRUNCATED AT 250 WORDS)..
  86. ncbi Ontogeny of atrial natriuretic peptide and its receptor in the lung: effects on perinatal surfactant release
    Christopher A D'Angelis
    Department of Pathology and Anatomical Sciences, State University of New York at Buffalo School of Medicine and Biomedical Sciences, Buffalo, New York 14214, USA
    Pediatr Res 63:239-44. 2008
    ..We speculate that increased activity of the ANP/NPR-A pathway in late gestation may prime the surfactant system, preparing the lung for air breathing...
  87. ncbi Molecular cloning of natriuretic peptide receptor A from bullfrog (Rana catesbeiana) brain and its functional expression
    T Sekiguchi
    Department of Biochemistry, Fukui Medical University, Shimoaizuki, Matsuoka, 910-1193, Fukui, Japan
    Gene 273:251-7. 2001
    ..This clearly indicates that the bullfrog receptor is a counterpart of mammalian NPR-A, and is specific for ANP or BNP but not for CNP...
  88. ncbi Natriuretic peptides like NO facilitate cardiac vagal neurotransmission and bradycardia via a cGMP pathway
    N Herring
    University Laboratory of Physiology, Oxford, United Kingdom
    Am J Physiol Heart Circ Physiol 281:H2318-27. 2001
    ..Like NO, BNP and CNP facilitate vagal neurotransmission and bradycardia. This may occur via a cGMP-PDE3-dependent pathway increasing cAMP-PKA-dependent phosphorylation of presynaptic N-type calcium channels...
  89. ncbi Activity and expression of soluble and particulate guanylate cyclases in myometrium from nonpregnant and pregnant women: down-regulation of soluble guanylate cyclase at term
    J F Telfer
    Department of Obstetrics and Gynecology, University of Glasgow, Glasgow, Scotland G31 2ER
    J Clin Endocrinol Metab 86:5934-43. 2001
    ..A reduction in cGMP availability may contribute to the switch to contractile activity at term...
  90. ncbi Local renal and vascular natriuretic peptide system in obstructive uropathic rats
    Soo Wan Kim
    Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Korea
    Urol Res 30:97-101. 2002
    ..Our results suggest that the local synthesis of natriuretic peptides is increased in the kidney and in the vasculature in obstructive uropathy...
  91. ncbi Vasopressin-dependent inhibition of the C-type natriuretic peptide receptor, NPR-B/GC-B, requires elevated intracellular calcium concentrations
    Sarah E Abbey
    Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Biol Chem 277:42423-30. 2002
    ..Together, these data reveal a dominant role for intracellular calcium in the reciprocal regulation of these two important vasoactive signaling systems...
  92. ncbi Role of natriuretic peptide receptor guanylyl cyclase-A in myocardial infarction evaluated using genetically engineered mice
    Michio Nakanishi
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Japan
    Hypertension 46:441-7. 2005
    ..These beneficial effects are mediated partly through inhibition of the renin-angiotensin system (RAS), although RAS-independent protective actions of guanylyl cyclase-A are also suggested...
  93. ncbi Postnatal changes in inhibitory effect of C-type natriuretic peptide on secretion of ANP
    Suhn Hee Kim
    Department of Physiology, Medical School, Institute for Medical Sciences, Jeonbug National University, JeonJu 561 180, Korea
    Am J Physiol Regul Integr Comp Physiol 282:R1672-9. 2002
    ..Therefore, we conclude that the inhibitory effect of CNP on atrial ANP secretion is developmentally regulated, being absent during normal cardiac development in young animals and intact in adult animals...
  94. ncbi Four peptide hormones' specific decrease (up to 97%) of human prostate carcinoma cells
    B A Vesely
    University of South Florida Cardiac Hormone Center and James A Haley Veterans Medical Center, Tampa, FL 33612, USA
    Eur J Clin Invest 35:700-10. 2005
    ..Whether these effects are specific and whether they have anticancer effects in prostate adenocarcinoma cells has not been determined...
  95. ncbi Lysophosphatidic acid inhibits C-type natriuretic peptide activation of guanylyl cyclase-B
    Sarah E Abbey
    Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Endocrinology 144:240-6. 2003
    ..We hypothesize that cross-talk between the LPA and CNP signaling pathway maximizes the response of fibroblasts in the wound-healing process...
  96. ncbi The atrial natriuretic peptide as a regulator of Kupffer cell functions
    Alexandra K Kiemer
    Department of Pharmacy, Center of Drug Research, Munich, Germany
    Shock 17:365-71. 2002
    ..In addition, we demonstrated that ANP enhances phagocytosis in KCs. These effects may contribute to the hepatoprotective actions of ANP...
  97. ncbi Atrial natriuretic factor and C-type natriuretic peptide induce retraction of human thyrocytes in monolayer culture via guanylyl cyclase receptors
    D F Sellitti
    Department of Medicine, Divisions of Endocrinology and Nephrology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road A3060, Bethesda, MD 20814 4799, USA
    J Endocrinol 173:169-76. 2002
    ..These results suggest that the actions of NPR-A and NPR-B, functional receptors in the human thyroid cell, may in part be mediated by cGMP-induced alterations in the cytoskeleton...
  98. ncbi Increased effects of C-type natriuretic peptide on cardiac ventricular contractility and relaxation in guanylyl cyclase A-deficient mice
    Melanie Pierkes
    Institute of Pharmacology and Toxicology, University of Munster, Domagkstrasse 12, D 48129 Munster, Germany
    Cardiovasc Res 53:852-61. 2002
    ..In the present study we evaluated the effects of ANP and CNP on cardiac function of wild-type (GC-A +/+) and GC-A-deficient (GC-A -/-) mice...
  99. ncbi Four cardiac hormones cause cell death of melanoma cells and inhibit their DNA synthesis
    Brian A Vesely
    Departments of Internal Medicine, University of South Florida Cardiac Hormone Center, Tampa, Florida 33612, USA
    Am J Med Sci 334:342-9. 2007
    ..Four cardiac hormones ie, atrial natriuretic peptide, vessel dilator, long-acting natriuretic peptide, and kaliuretic peptide, have significant anticancer effects in adenocarcinomas...
  100. ncbi Beneficial effects of phosphodiesterase 5 inhibition in pulmonary hypertension are influenced by natriuretic Peptide activity
    Lan Zhao
    Section on Clinical Pharmacology, Imperial College School of Science, Technology and Medicine, Hammersmith Hospital, London, England
    Circulation 107:234-7. 2003
    ..The role of natriuretic peptides in the response to sildenafil was examined in mice lacking NPR-A, a guanylyl cyclase-linked natriuretic peptide receptor, in which pulmonary hypertension was induced by hypoxia...
  101. ncbi Dietary salt supplementation selectively downregulates NPR-C receptor expression in kidney independently of ANP
    Ju Zhong Sun
    Vascular Biology and Hypertension Program, Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham, 35294, USA
    Am J Physiol Renal Physiol 282:F220-7. 2002
    ....

Research Grants21

  1. ATRIAL PEPTIDE REGULATION OF SODIUM TRANSPORT
    Mark Zeidel; Fiscal Year: 1990
    ..The studies will define the role of ANP in the regulation of sodium transport in the inner medullary collecting duct, the final arbiter of urinary sodium excretion...
  2. ANP RECEPTOR-MEDIATED OF FUNCTIONS IN GLOMERULAR CELLS
    BARBARA BALLERMANN; Fiscal Year: 1992
    ..It is anticipated that the proposed studies will enhance our understanding of the cellular mechanisms underlying essential hypertension...
  3. Role of Natriuretic Peptides in the Cochlea
    George Trachte; Fiscal Year: 2004
    ..abstract_text> ..
  4. NEW APPROACH TO ENDOTHELIAL CLEFT STRUCTURE
    Fitz Roy E Curry; Fiscal Year: 2010
    ..Our experiments evaluate the common mechanical properties of the endothelial glycocalyx that modulate water, solute, leukocyte, and red cell fluxes at the endothelial cell surface. ..
  5. IMPROVEMENT OF MEMBRANE BIOLOGY FACILITY
    FITZ ROY CURRY; Fiscal Year: 2002
    ..That project addressed other laboratory and basic infrastructure deficiencies in the same building that contains the subject laboratories in the current application. ..
  6. REGULATION OF ANP RECEPTOR ACTIVITY IN VASCULAR CELLS
    David G Gardner; Fiscal Year: 2011
    ..Collectively, this proposal should provide us with a detailed understanding of how the NPR-A gene is regulated and the role that this regulation plays in the control of cardiovascular homeostasis. ..
  7. cAMP Phosphodiesterase and Lung Endothelial Cell Permeability
    Thomas C Rich; Fiscal Year: 2010
    ..Here we propose to determine whether pharmacological and molecular inhibitors of a specific protein, phosphodiesterase type 7, prevent increases in endothelial permeability in these arteries, and hence, make breathing easier. ..
  8. Intestinal Peptides Involved in Volume Homeostasis
    MICHAEL GOY; Fiscal Year: 2009
    ..Experiments described in our application will test and extend this hypothesis, and may suggest uses for proUGn in the diagnosis or treatment of diseases in which salt and/or fluid homeostasis is deranged. ..
  9. Cyclic AMP signaling in cardiac myocytes
    THOMAS RICH; Fiscal Year: 2007
    ..g., protenoid, beta1-,or beta2-adrenergic receptors) or inhibit phosphodiesterase (PDE) will shed new light on the physiologic functions of these enzymes and their relation to cardiac function. ..
  10. GENETICS OF HEART AND KIDNEY DAMAGE IN HYPERTENSION
    Christian Deschepper; Fiscal Year: 2004
    ..abstract_text> ..
  11. MOLECULAR BIOLOGY OF DIABETIC CATARACT FORMATION
    PATRICK CAMMARATA; Fiscal Year: 2004
    ..This study proposes to test the potential usefulness of enhancing myo-inositol efflux through chloride channels as a means for drug therapy to relieve intrafiber osmotic stress. ..
  12. EXPRESSION AND REGULATION OF ATRIAL NATRIURETIC FACTOR
    David Gardner; Fiscal Year: 2002
    ..abstract_text> ..
  13. REGULATORY MECHANISMS OF GROWTH-PLATE CHONDROCYTES
    Robert Olney; Fiscal Year: 2002
    ..Conversely, by identifying the important regulators of the human growth-plate, we will provide clues to direct the search for the genes responsible for some of the osteochondrodysplasias. ..
  14. PEPTIDE REGULATION OF THE CHOROID PLEXUS-CSF SYSTEM
    Conrad Johanson; Fiscal Year: 2002
    ..Our long-term goal is to delineate the multifunctional roles of CP in brain fluid homeostasis. ..
  15. PERINATAL HYPOXIA PROGRAMS THE ADULT HEART
    A Hohimer; Fiscal Year: 2002
    ..Each organism's genetic program undoubtably interacts with early environmental stresses to influence adult morphology and function as well as susceptibility to disease and aging. ..
  16. Age-Related Decrease in A-Beta Peptide Clearance Pathways: CSF and BBB
    Conrad Earl Johanson; Fiscal Year: 2010
    ..Translation: Ap is an expedient marker to analyze aging effects on ISF-CSF relationships, and the compromised solute clearance by malfunctioning barrier systems. This sheds light on neurodegeneration. ..