presynaptic receptors

Summary

Summary: Neurotransmitter receptors located on or near presynaptic terminals or varicosities. Presynaptic receptors which bind transmitter molecules released by the terminal itself are termed AUTORECEPTORS.

Top Publications

  1. ncbi Presynaptic receptors
    R J Miller
    Department of Pharmacological and Physiological Sciences, University of Chicago, Illinois 60637, USA
    Annu Rev Pharmacol Toxicol 38:201-27. 1998
  2. ncbi Activity-dependent synaptic plasticity in the central nucleus of the amygdala
    Rachel D Samson
    Center for Molecular and Behavioral Neuroscience, Rutgers, The State University of New Jersey, Newark, New Jersey 07102, USA
    J Neurosci 25:1847-55. 2005
  3. pmc GABA and glutamate release affected by GABAB receptor antagonists with similar potency: no evidence for pharmacologically different presynaptic receptors
    P C Waldmeier
    Research Department, Ciba Geigy Ltd, Basel, Switzerland
    Br J Pharmacol 113:1515-21. 1994
  4. ncbi Presynaptic NMDA autoreceptors facilitate axon excitability: a new molecular target for the anticonvulsant gabapentin
    Luz M Suárez
    Servicio de Neurobiologia, Dpto de Investigación, Hospital Ramon y Cajal, Ctra de Colmenar Km 9, Madrid 28034, Spain
    Eur J Neurosci 21:197-209. 2005
  5. ncbi Molecular mechanisms underlying the modulation of exocytotic noradrenaline release via presynaptic receptors
    Helmut Kubista
    Institute of Pharmacology, Centre of Biomolecular Medicine and Pharmacology, Medical University of Vienna, Waehringer Strasse 13a, A 1090 Vienna, Austria
    Pharmacol Ther 112:213-42. 2006
  6. ncbi Inhibition of dopamine release via presynaptic D2 receptors: time course and functional characteristics in vivo
    M Benoit-Marand
    Centre National de la Recherche Scientifique Unite Mixte de Recherche 5541, Universite Victor Segalen, 33076 Bordeaux, France
    J Neurosci 21:9134-41. 2001
  7. ncbi Neocortical LTD via coincident activation of presynaptic NMDA and cannabinoid receptors
    Per Jesper Sjöström
    Department of Biology, Volen Center for Complex Systems, Brandeis University, Mailstop 008, 415 South Street, Waltham, MA 02454, USA
    Neuron 39:641-54. 2003
  8. ncbi Fine tuning of sympathetic transmitter release via ionotropic and metabotropic presynaptic receptors
    Stefan Boehm
    Institute of Pharmacology, University of Vienna, Vienna, Austria
    Pharmacol Rev 54:43-99. 2002
  9. pmc Background synaptic activity in rat entorhinal cortical neurones: differential control of transmitter release by presynaptic receptors
    Roland S G Jones
    Department of Pharmacology, University of Bath, Claverton Down, Bath BA2 7AY, UK
    J Physiol 562:107-20. 2005
  10. ncbi Modeling of twitch fade based on slow interaction of nondepolarizing muscle relaxants with the presynaptic receptors
    Shashi B Bhatt
    Department of Anesthesiology, Medical University of Ohio, Toledo, USA
    J Pharmacokinet Pharmacodyn 33:461-83. 2006

Detail Information

Publications218 found, 100 shown here

  1. ncbi Presynaptic receptors
    R J Miller
    Department of Pharmacological and Physiological Sciences, University of Chicago, Illinois 60637, USA
    Annu Rev Pharmacol Toxicol 38:201-27. 1998
    Activation of different types of G-protein-linked and ionotropic presynaptic receptors has been shown to regulate neurotransmitter release throughout the central and peripheral nervous systems...
  2. ncbi Activity-dependent synaptic plasticity in the central nucleus of the amygdala
    Rachel D Samson
    Center for Molecular and Behavioral Neuroscience, Rutgers, The State University of New Jersey, Newark, New Jersey 07102, USA
    J Neurosci 25:1847-55. 2005
    ..These results are consistent with the idea that the CEm plays an active role in fear conditioning...
  3. pmc GABA and glutamate release affected by GABAB receptor antagonists with similar potency: no evidence for pharmacologically different presynaptic receptors
    P C Waldmeier
    Research Department, Ciba Geigy Ltd, Basel, Switzerland
    Br J Pharmacol 113:1515-21. 1994
    ..5. In particular, our results with CGP 35348 and CGP 52432 do not support the hypothesis that GABAB autoreceptors and GABAB heteroreceptors on glutamatergic nerve endings represent subtypes with different pharmacology...
  4. ncbi Presynaptic NMDA autoreceptors facilitate axon excitability: a new molecular target for the anticonvulsant gabapentin
    Luz M Suárez
    Servicio de Neurobiologia, Dpto de Investigación, Hospital Ramon y Cajal, Ctra de Colmenar Km 9, Madrid 28034, Spain
    Eur J Neurosci 21:197-209. 2005
    ..These findings suggest that sodium entry through presynaptic NMDA-R channels facilitates axon excitability. The interaction of gabapentin with this newly described mechanism might contribute to its therapeutic benefits...
  5. ncbi Molecular mechanisms underlying the modulation of exocytotic noradrenaline release via presynaptic receptors
    Helmut Kubista
    Institute of Pharmacology, Centre of Biomolecular Medicine and Pharmacology, Medical University of Vienna, Waehringer Strasse 13a, A 1090 Vienna, Austria
    Pharmacol Ther 112:213-42. 2006
    The release of noradrenaline from nerve terminals is modulated by a variety of presynaptic receptors. These receptors belong to one of the following three receptor superfamilies: transmitter-gated ion channels, G protein-coupled ..
  6. ncbi Inhibition of dopamine release via presynaptic D2 receptors: time course and functional characteristics in vivo
    M Benoit-Marand
    Centre National de la Recherche Scientifique Unite Mixte de Recherche 5541, Universite Victor Segalen, 33076 Bordeaux, France
    J Neurosci 21:9134-41. 2001
    ..First, it contributes to the attenuation of extracellular dopamine during bursts. Second, autoinhibition elicited by one burst transiently attenuates further dopamine release elicited by tonic activity...
  7. ncbi Neocortical LTD via coincident activation of presynaptic NMDA and cannabinoid receptors
    Per Jesper Sjöström
    Department of Biology, Volen Center for Complex Systems, Brandeis University, Mailstop 008, 415 South Street, Waltham, MA 02454, USA
    Neuron 39:641-54. 2003
    ..This novel form of coincidence detection may explain the temporal window of tLTD and may also impart synapse specificity to cannabinoid retrograde signaling...
  8. ncbi Fine tuning of sympathetic transmitter release via ionotropic and metabotropic presynaptic receptors
    Stefan Boehm
    Institute of Pharmacology, University of Vienna, Vienna, Austria
    Pharmacol Rev 54:43-99. 2002
    ..In this respect, presynaptic receptors located on the sympathetic axon terminals are of utmost importance, because they are activated by ..
  9. pmc Background synaptic activity in rat entorhinal cortical neurones: differential control of transmitter release by presynaptic receptors
    Roland S G Jones
    Department of Pharmacology, University of Bath, Claverton Down, Bath BA2 7AY, UK
    J Physiol 562:107-20. 2005
    ....
  10. ncbi Modeling of twitch fade based on slow interaction of nondepolarizing muscle relaxants with the presynaptic receptors
    Shashi B Bhatt
    Department of Anesthesiology, Medical University of Ohio, Toledo, USA
    J Pharmacokinet Pharmacodyn 33:461-83. 2006
    ..The rates of interaction with the presynaptic receptors were characterized in terms of the arbitrarily assigned equilibrium dissociation constant and the half-..
  11. pmc Functional roles of presynaptic GABA(A) receptors on glycinergic nerve terminals in the rat spinal cord
    Il Sung Jang
    Cellular and System Physiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    J Physiol 541:423-34. 2002
    ....
  12. ncbi Effects of treadmill running on short-term pre-synaptic plasticity at dentate gyrus of streptozotocin-induced diabetic rats
    Parham Reisi
    Laboratory of Physiology, Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
    Brain Res 1211:30-6. 2008
    ....
  13. ncbi Mu-opioid-mediated inhibition of glutamate synaptic transmission in rat central amygdala neurons
    W Zhu
    Department of Anesthesiology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Neuroscience 133:97-103. 2005
    ..This study provides evidence for the presynaptic regulation of glutamate synaptic transmission by mu-opioid receptors in CeA neurons...
  14. ncbi Release-independent short-term facilitation at GABAergic synapses in the olfactory bulb
    Z Nusser
    Laboratory of Cellular Neurophysiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, Szigony Street 43, 1083 Budapest, Hungary
    Neuropharmacology 43:573-83. 2002
    ..These results reveal a heterogeneity in the short-term plasticity of evoked IPSCs in juxtaglomerular cells and demonstrate that the short-term facilitation at some GABAergic synapses is independent of release...
  15. ncbi Long-term potentiation alters the modulator pharmacology of AMPA-type glutamate receptors
    Bin Lin
    Department of Psychiatry, University of California, Irvine, California 92697, USA
    J Neurophysiol 87:2790-800. 2002
    ..Candidates for the changes responsible for the observed effects of LTP were evaluated using a model of AMPA receptor kinetics; a simple increase in the channel opening rate provided the most satisfactory match with the LTP data...
  16. pmc Presynaptic modulation of synaptic transmission by opioid receptor in rat subthalamic nucleus in vitro
    Ke Zhong Shen
    Department of Physiology and Pharmacology, Oregon Health Sciences University, Portland, OR 97201, USA
    J Physiol 541:219-30. 2002
    ..In contrast, inhibition of excitatory synaptic inputs to the STN occurs through the activation of only mu-receptors. Both inhibitions may be mediated by blockade of voltage-dependent potassium conductance...
  17. ncbi 4-Chloro-m-cresol, an activator of ryanodine receptors, inhibits voltage-gated K(+) channels at the rat calyx of Held
    Daisuke Suzuki
    Department of Neurophysiology, University of Tokyo Graduate School of Medicine, Tokyo, Japan
    Eur J Neurosci 26:1530-6. 2007
    ..02 mm) had no effect on the 4-CmC-induced TIFC potentiation. We conclude that the facilitatory effect of 4-CmC on nerve-evoked transmitter release is mediated by its inhibitory effect on I(pK)...
  18. ncbi Acetylcholine attenuates synaptic GABA release to supraoptic neurons through presynaptic nicotinic receptors
    D P Li
    Department of Anesthesiology, H187, Penn State University College of Medicine, 500 University Drive, Hershey, PA 17033-0850, USA
    Brain Res 920:151-8. 2001
    ..Activation of presynaptic nicotinic receptors located in the GABAergic terminals plays a major role in the cholinergic regulation of the inhibitory GABAergic input to SON neurons...
  19. ncbi Dopamine presynaptically depresses fast inhibitory synaptic transmission via D4 receptor-protein kinase A pathway in the rat dorsolateral septal nucleus
    Yasuo Asaumi
    Department of Physiology, Kurume University School of Medicine, Japan
    J Neurophysiol 96:591-601. 2006
    ..These results suggest that DA inhibits spontaneous and evoked release of GABA via the D4 receptor-G(i)-protein-PKA system in DLSN neurons...
  20. ncbi Presynaptic GABAA receptors facilitate spontaneous glutamate release from presynaptic terminals on mechanically dissociated rat CA3 pyramidal neurons
    I S Jang
    Department of Pharmacology, School of Dentistry, Kyungpook National University, 188 1, Samduk 2 Ga dong, Daegu 700 412, Republic of Korea
    Neuroscience 138:25-35. 2006
    ....
  21. ncbi Presynaptic alpha1 adrenergic receptors differentially regulate synaptic glutamate and GABA release to hypothalamic presympathetic neurons
    Qian Chen
    Department of Anesthesiology, Pennsylvania State University College of Medicine, Hershey, 17033, USA
    J Pharmacol Exp Ther 316:733-42. 2006
    ..Thus, these data suggest that activation of alpha (1)adrenergic receptors increases the excitability of PVN presympathetic neurons primarily through augmentation of glutamatergic tone and attenuation of GABAergic inputs...
  22. ncbi Feed-forward facilitation of glutamate release by presynaptic GABA(A) receptors
    I S Jang
    Department of Pharmacology, Graduate School of Medical Sciences, Kyushu University, Maidashi 3 1 1, Fukuoka 812 8582, Japan
    Neuroscience 135:737-48. 2005
    ..The present results provide a novel form of presynaptic modulation (feed-forward facilitation) of glutamatergic transmission by presynaptic GABA(A) receptors within the intrinsic hippocampal neural circuits...
  23. ncbi Contribution of presynaptic Na(+) channel inactivation to paired-pulse synaptic depression in cultured hippocampal neurons
    Yejun He
    Department of Psychiatry, Washington University School of Medicine, 660 South Euclid Ave, St Louis, Missouri 63110, USA
    J Neurophysiol 87:925-36. 2002
    ..The results suggest that NaCh inactivation is poised to modulate EPSC amplitude with small tonic depolarizations that likely occur with physiological or pathophysiological activity...
  24. ncbi Adaptation to synaptic inactivity in hippocampal neurons
    Tara C Thiagarajan
    Department of Molecular and Cellular Physiology, Beckman Center, Stanford University School of Medicine, Stanford, California 94305, USA
    Neuron 47:725-37. 2005
    ..These results extend beyond "synaptic homeostasis" to involve more profound changes that can be better described as "metaplasticity"...
  25. ncbi Cannabinoids modulate synaptic activity in the rat supraoptic nucleus
    A Soya
    Deparment of Physiology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
    J Neuroendocrinol 17:609-15. 2005
    ..The results indicate that cannabinoids modulate the activity of magnocellular neurosecretory neurones by presynaptic inhibition of both excitatory and inhibitory synaptic transmission...
  26. ncbi Excitatory connections made by presynaptic cortico-cortical pyramidal cells in layer 6 of the neocortex
    Audrey Mercer
    Department of Pharmacology, The School of Pharmacy, University of London, 29 39 Brunswick Square, London WC1N 1AX, UK
    Cereb Cortex 15:1485-96. 2005
    ....
  27. ncbi Pre- and postsynaptic modulation of glycinergic and gabaergic transmission by muscarinic receptors on rat hypoglossal motoneurons in vitro
    S E Pagnotta
    Neurobiology Sector and INFM Unit, International School for Advanced Studies SISSA, Via Beirut 4, 34014 Trieste, Italy
    Neuroscience 130:783-95. 2005
    ....
  28. ncbi Endogenous and exogenous dopamine presynaptically inhibits glutamatergic reticulospinal transmission via an action of D2-receptors on N-type Ca2+ channels
    Erik Svensson
    The Nobel Institute for Neurophysiology, Department of Neuroscience, Karolinska Institutet, S 171 77 Stockholm, Sweden
    Eur J Neurosci 17:447-54. 2003
    ..DA did not affect the response to extracellularly ejected d-glutamate, the postsynaptic membrane potential, or the electrical component of the EPSPs. DA thus acts at the presynaptic level to modulate reticulospinal transmission...
  29. ncbi Presynaptic inhibition of Schaffer collateral synapses by stimulation of hippocampal cholinergic afferent fibres
    David Fernandez de Sevilla
    Instituto Cajal, CSIC, Avenida Doctor Arce 37, 28002 Madrid, Spain
    Eur J Neurosci 17:555-8. 2003
    ....
  30. pmc Presynaptic group I metabotropic glutamate receptors modulate synaptic transmission in the rat superior colliculus via 4-AP sensitive K(+) channels
    Anne Marie White
    Department of Biomedical Sciences, Institute of Medical Sciences, Foresterhill, University of Aberdeen, Aberdeen AB25 2ZD, Scotland
    Br J Pharmacol 140:1421-33. 2003
    ..6. Our data indicate that group I agonists regulate transmitter release, presumably via an autoreceptor in the SC. This receptor may be involved in adaptation to repetitive stimulation via a non-PLC mediated pathway...
  31. ncbi Mutation and activation of Galpha s similarly alters pre- and postsynaptic mechanisms modulating neurotransmission
    Robert B Renden
    Interdepartmental Program in Neuroscience, University of Utah, Salt Lake City 84112 0840, USA
    J Neurophysiol 89:2620-38. 2003
    ....
  32. ncbi Activation of group III metabotropic glutamate receptors presynaptically reduces both GABAergic and glutamatergic transmission in the rat globus pallidus
    T Matsui
    Department of Anatomy and Neurobiology, College of Medicine, The University of Tennessee Memphis, 855 Monroe Avenue, Memphis, TN 38163, USA
    Neuroscience 122:727-37. 2003
    ..L-AP4 failed to change iontophoretic glutamate induced responses. These results suggest that the subthalamo-pallidal glutamatergic input might homo- and hetero-synaptically control GABAergic and glutamatergic transmission in the GP...
  33. pmc Unmyelinated axons in the rat hippocampus hyperpolarize and activate an H current when spike frequency exceeds 1 Hz
    A F Soleng
    Institute of Basic Medical Sciences, University of Oslo, Norway
    J Physiol 552:459-70. 2003
    ..We interpret these results as an activity-induced hyperpolarization that is partly counteracted by Ih. Such a hyperpolarization may influence transmitter release and the conduction reliability of these axons...
  34. pmc GABA mediates autoreceptor feedback inhibition in the rat carotid body via presynaptic GABAB receptors and TASK-1
    Ian M Fearon
    Department of Biology, McMaster University, 1280 Main Street West, Hamilton, Ontario L8S 4K1, Canada
    J Physiol 553:83-94. 2003
    ..Thus GABAB receptor-mediated activation of TASK-1 or a related channel provides a presynaptic autoregulatory feedback mechanism that modulates fast synaptic transmission in the rat carotid body...
  35. ncbi Pre- and postsynaptic contribution of GABAC receptors to GABAergic synaptic transmission in rat collicular slices and cultures
    Sergei Kirischuk
    Developmental Physiology, Johannes Muller Institute of Physiology, Humboldt University Medical School Charité, Tucholskystrasse 2, 10117 Berlin, Germany
    Eur J Neurosci 18:752-8. 2003
    ..Thus, in GABAergic synapses of the SC GABACRs are involved in pre- and postsynaptic functions and may therefore contribute to the activity-dependent adjustment of GABAergic inhibition...
  36. ncbi Kindling alters entorhinal cortex-hippocampal interaction by increased efficacy of presynaptic GABA(B) autoreceptors in layer III of the entorhinal cortex
    Tengis Gloveli
    Johannes Müller Institute of Physiology at the Charité, Humboldt University Berlin, Tucholskystr 2, 10117, Berlin, Germany
    Neurobiol Dis 13:203-12. 2003
    ..Thus, in kindled animals activation of the layer III-CA1 pathway is facilitated by an increased GABA(B) receptor-mediated autoinhibition leading to an enhanced activation of the monosynaptic EC-CA1 pathway...
  37. ncbi Presynaptic alpha-7 nicotinic acetylcholine receptors modulate excitatory synaptic transmission in hippocampal neurons
    Zhen Wei Liu
    Beijing Institute of Pharmacology and Toxicology, Beijing 100850
    Sheng Li Xue Bao 55:731-5. 2003
    ....
  38. pmc The contribution of intracellular calcium stores to mEPSCs recorded in layer II neurones of rat barrel cortex
    Christopher R L Simkus
    Institute of Neuroinformatics, University of Zürich and Federal Institute of Technology ETH, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    J Physiol 545:521-35. 2002
    ..Statistical evidence is presented for Ca(2+)-induced Ca(2+) release (CICR) from ryanodine stores after the spontaneous opening of IP(3) stores...
  39. pmc Dual and opposing roles of presynaptic Ca2+ influx for spontaneous GABA release from rat medial preoptic nerve terminals
    Michael Druzin
    Department of Integrative Medical Biology, Section for Physiology, Umea University, S 901 87 Umea, Sweden
    J Physiol 542:131-46. 2002
    ..The results are explained by a model with parallel Ca2+ influx through channels coupled to the exocytotic machinery and through channels coupled to Ca2+-activated K+ channels at a distance from the release site...
  40. ncbi The linoleic acid derivative FR236924 facilitates hippocampal synaptic transmission by enhancing activity of presynaptic alpha7 acetylcholine receptors on the glutamatergic terminals
    S Yamamoto
    Department of Physiology, Hyogo College of Medicine, 1 1 Mukogawa cho, Nishinomiya 663 8501, Japan
    Neuroscience 130:207-13. 2005
    ..This may provide evidence for a link between cis-unsaturated free fatty acids and presynaptic alpha7 ACh receptors in hippocampal synaptic plasticity...
  41. ncbi Gabapentin inhibits presynaptic Ca(2+) influx and synaptic transmission in rat hippocampus and neocortex
    Johannes A van Hooft
    Swammerdam Institute for Life Sciences, Neurobiology Section, University of Amsterdam, P O Box 94084, NL 1090 GB, Amsterdam, The Netherlands
    Eur J Pharmacol 449:221-28. 2002
    ..Taken together, the results suggest that Gabapentin selectively inhibits Ca(2+) influx by inhibiting VOCCs in a subset of excitatory and inhibitory presynaptic terminals, thereby attenuating synaptic transmission...
  42. ncbi Presynaptic group III mGluR modulation of short-term plasticity in the lateral perforant path of the dentate gyrus in vitro
    Anthony M Rush
    Department of Physiology, Trinity College, Dublin 2, Ireland
    Brain Res 952:38-43. 2002
    ..Short-term facilitation became prominent at high stimulation frequencies as short-term depression was inhibited by activation of group III mGluR. Activation of group III mGluR also shifted the limiting frequency to higher values...
  43. pmc Glutamate suppresses GABA release via presynaptic metabotropic glutamate receptors at baroreceptor neurones in rats
    Chao Yin Chen
    Department of Medical Pharmacology and Toxicology, Tupper Hall Room 1311, University of California Davis, One Shields Avenue, Davis, CA 95616, USA
    J Physiol 562:535-51. 2005
    ....
  44. ncbi Acute desensitization of presynaptic GABAB-mediated inhibition and induction of epileptiform discharges in the neonatal rat hippocampus
    P Tosetti
    INMED, INSERM U29, Parc Scientifique de Luminy, BP13, 13273 Marseille, France
    Eur J Neurosci 19:3227-34. 2004
    ..Conditions that induce desensitization of the GABA(B)-mediated responses also trigger persistent epileptiform discharges in the neonatal rat hippocampus...
  45. ncbi Multi-unit spike-triggered averaging: a method for probing the physiology of central synapses
    Chris M Hempel
    Department of Biology, Brandeis University, Waltham, MA 02454, USA
    J Neurosci Methods 120:121-9. 2002
    ..Since it requires only a single intracellular recording, multi-unit STA might be a suitable method for probing unitary synaptic connections in the intact brain, where obtaining multiple intracellular recordings is not feasible...
  46. ncbi Bidirectional modification of presynaptic neuronal excitability accompanying spike timing-dependent synaptic plasticity
    Cheng Yu Li
    Institute of Neuroscience, Chinese Academy of Sciences, Shanghai Institute of Biological Sciences
    Neuron 41:257-68. 2004
    ....
  47. ncbi Presynaptic mechanism for anti-analgesic and anti-hyperalgesic actions of kappa-opioid receptors
    Bihua Bie
    Department of Symptom Research, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    J Neurosci 23:7262-8. 2003
    ....
  48. ncbi Acute and chronic ethanol exposure differentially affect induction of hippocampal LTP
    Satoshi Fujii
    Department of Physiology, Yamagata University School of Medicine, Yamagata 990 9585, Japan
    Brain Res 1211:13-21. 2008
    ....
  49. ncbi The pool of fast releasing vesicles is augmented by myosin light chain kinase inhibition at the calyx of Held synapse
    Geetha Srinivasan
    The Vollum Institute, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA
    J Neurophysiol 99:1810-24. 2008
    ..Overall, our data suggest that MLCK plays a crucial role in determining the size of the pool of synaptic vesicles that undergo fast release at a CNS synapse...
  50. ncbi 5-HT excites globus pallidus neurons by multiple receptor mechanisms
    L Chen
    Department of Physiology, The Chinese University of Hong Kong, Shatin, Hong Kong, China
    Neuroscience 151:439-51. 2008
    ..In view of the extensive innervation by globus pallidus neurons on other basal ganglia nuclei, this action of 5-HT originated from the raphe may have a profound effect on the operation of the entire basal ganglia network...
  51. ncbi Presynaptic kainate receptors modulating glutamatergic transmission in the rat hippocampus are inhibited by arachidonic acid
    Rodrigo A Cunha
    Center for Neuroscience of Coimbra, Institute of Biochemistry, Faculty of Medicine, University of Coimbra, 3004 504 Coimbra, Portugal
    Neurochem Int 44:371-9. 2004
    ..These results indicate that AA directly inhibits presynaptic kainate receptor controlling glutamate release in the CA1 area of the rat hippocampus...
  52. pmc Cajal Retzius cells in the mouse neocortex receive two types of pre- and postsynaptically distinct GABAergic inputs
    Knut Kirmse
    Institute of Neurophysiology, Johannes Mueller Center of Physiology, Charite University Medicine Berlin, Tucholskystrasse 2, 10117 Berlin, Germany
    J Physiol 585:881-95. 2007
    ..Thus, CR cells receive two GABAergic inputs, which differ in the quantal amplitude, the probability of GABA release and the frequency dependence of signal transfer...
  53. pmc Activation of presynaptic kainate receptors suppresses GABAergic synaptic transmission in the rat globus pallidus
    X T Jin
    Division of Neuroscience, Yerkes National Primate Research Center, Atlanta, GA 30322, USA
    Neuroscience 149:338-49. 2007
    ..These findings open up the possibility for the development of KA-mediated pharmacotherapies aimed at decreasing the excessive and abnormally regulated inhibition of GP neurons in Parkinson's disease...
  54. pmc Presynaptic regulation of dendrodendritic dopamine transmission
    Michael J Beckstead
    Vollum Institute, L474, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR, USA
    Eur J Neurosci 26:1479-88. 2007
    ..With increased activity, the release probability decreased and a burst of activity caused a relative facilitation of dopamine release. This form of regulation would be expected to limit activity within the cell body region...
  55. ncbi Prolonged exposure to levetiracetam reveals a presynaptic effect on neurotransmission
    Xiao Feng Yang
    Department of Neurology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Epilepsia 48:1861-9. 2007
    ..Using a combination of electrophysiological and cellular imaging techniques, we carefully tested the hypothesis that LEV directly interferes with neurotransmitter release...
  56. ncbi Codeine presynaptically inhibits the glutamatergic synaptic transmission in the nucleus tractus solitarius of the guinea pig
    Y Ohi
    Department of Molecular and Medical Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
    Neuroscience 146:1425-33. 2007
    ....
  57. ncbi Dopamine D2 receptor mediated presynaptic inhibition of striatopallidal GABA(A) IPSCs in vitro
    A J Cooper
    Department of Pharmacology, Division of Neuroscience, The Medical School, The University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    Neuropharmacology 41:62-71. 2001
    ..Attenuation of this mechanism following the depletion of dopamine may contribute to the changes in GP neuronal activity observed in animal models of Parkinson's disease...
  58. ncbi Serotonin activates presynaptic and postsynaptic receptors in rat globus pallidus
    Kenji Hashimoto
    Department of Anatomy and Neurobiology, College of Medicine, The University of Tennessee, Memphis, TN 38163, USA
    J Neurophysiol 99:1723-32. 2008
    ..The present results provided evidence that 5-HT exerts significant control over the synaptic inputs and the autonomous activity of pallidal neurons...
  59. pmc Modulation of GABAergic inhibition in the rat superior colliculus by a presynaptic group II metabotropic glutamate receptor
    S A Neale
    Department of Visual Science, Institute of Ophthalmology, University College London, 11 43 Bath Street, London EC1V 9EL, UK
    J Physiol 577:659-69. 2006
    ..Thus mGluR2 receptors could have a function in activity-dependent modulation of inhibitory processing during visual responses...
  60. ncbi Presynaptic efficacy directs normalization of synaptic strength in layer 2/3 rat neocortex after paired activity
    Neil R Hardingham
    The University Laboratory of Physiology, Oxford University, Oxford, UK
    J Neurophysiol 97:2965-75. 2007
    ..This may represent a means by which distal synapses preferentially increase their efficacy to achieve equal weighting at the soma. Paired activity thus acts to normalize synaptic strength, by both pre- and postsynaptic mechanisms...
  61. ncbi Activation of group III mGluRs inhibits GABAergic and glutamatergic transmission in the substantia nigra pars reticulata
    M Wittmann
    Department of Pharmacology, Emory University, Atlanta, Georgia 30322, USA
    J Neurophysiol 85:1960-8. 2001
    ....
  62. pmc Role of histamine in rodent antinociception
    P Malmberg Aiello
    Department of Preclinical and Clinical Pharmacology, University of Florence, Italy
    Br J Pharmacol 111:1269-79. 1994
    ..Involvement of the histaminergic system in the modulation of nociceptive stimuli is thus proposed...
  63. pmc Formoterol and salbutamol inhibit bradykinin- and histamine-induced airway microvascular leakage in guinea-pig
    C Advenier
    Laboratoire de Pharmacologie, , France
    Br J Pharmacol 105:792-8. 1992
    ..the higher efficacy of beta2-adrenoceptor agonists versus bradykinin may occur through activation of presynaptic receptors of the non-adrenergic non-cholinergic (NANC) nerves preventing release of inflammatory neuropeptides such ..
  64. pmc Subtype classification of the presynaptic alpha-adrenoceptors which regulate [3H]-noradrenaline secretion in guinea-pig isolated urethra
    P Alberts
    Department of Receptor Pharmacology, Urology and Gynaecology, Kabi Pharmacia Therapeutics, Stockholm, Sweden
    Br J Pharmacol 105:142-6. 1992
    1. The following experiments were carried out to investigate the presence and type of functional presynaptic receptors in adrenergic nerves of the guinea-pig urethra. 2...
  65. ncbi Presynaptic inhibition produced by histamine at nicotinic synapses in enteric ganglia
    K Tamura
    Department of Physiology, College of Medicine, Ohio State University, Columbus 43210
    Neuroscience 25:171-9. 1988
    ..Based on these results, the presynaptic receptors involved in this inhibitory mechanism appeared to be of a pharmacologically atypical histamine receptor ..
  66. pmc Peripheral sympatho-inhibitory cardiovascular effects of opioid peptides in anaesthetized rabbits
    B Szabo
    Pharmakologisches Institut der Universität, Freiburg i Br, Federal Republic of Germany
    Br J Pharmacol 94:781-8. 1988
    ..cardiovascular tissues from rabbits, as well as the cardiovascular system of pithed rabbits, through presynaptic receptors on postganglionic sympathetic nerve fibres...
  67. pmc Involvement of pertussis toxin-sensitive and -insensitive mechanisms in alpha-adrenoceptor modulation of noradrenaline release from rat sympathetic neurones in tissue culture
    C E Hill
    Division of Neuroscience, John Curtin School of Medical Research, Australian National University, Canberra
    Br J Pharmacol 110:281-8. 1993
    ..and maintained in tissue culture were used to investigate the modulation of neurotransmitter release by presynaptic receptors. Three week old cultures of neurones were loaded with [3H]-noradrenaline to label endogenous ..
  68. ncbi Mechanistic insights on spider neurotoxins
    Andreas Luch
    Department of Product Safety, Center for Alternatives to Animal Experiments, German Federal Institute for Risk Assessment, Berlin, Germany
    EXS 100:293-315. 2010
    ..Upon binding to one of its specific presynaptic receptors, alpha-LTX has been shown to tetramerize under physiological conditions to form Ca2+-permeable pores in ..
  69. ncbi Pharmacodynamic analysis of contractile potentiation by cholinesterase inhibitors in rats
    K Yamamoto
    Department of Pharmacy, University of Tokyo Hospital, Faculty of Medicine, Japan
    J Pharmacokinet Biopharm 24:327-48. 1996
    ..Other process such as desensitisization induced by endogenous ACh diffusion rate of drugs into the synaptic cleft, action of presynaptic receptors, etc., might contribute to the dose-effect relationship of ChE inhibitors.
  70. ncbi Effects of chronic paroxetine treatment on dialysate serotonin in 5-HT1B receptor knockout mice
    A M Gardier
    Laboratoire de Neuropharmacologie EA3544 MENRT, Faculté de Pharmacie IFR75 ISIT Institut de Signalisation et d Innovation Thérapeutique, Universite Paris Sud, Chatenay Malabry, France
    J Neurochem 86:13-24. 2003
    ..These presynaptic receptors retain their capacity to limit 5-HT release mainly in the ventral hippocampus following chronic paroxetine ..
  71. ncbi Physiological regulation of penile arteries and veins
    D Prieto
    Departamento de Fisiologia, Facultad de Farmacia, Universidad Complutense de Madrid, Madrid, Spain
    Int J Impot Res 20:17-29. 2008
    ..receptors and downregulates its own release and that of nitric oxide (NO) through alpha(2)-presynaptic receptors. The sympathetic cotransmitter neuropeptide Y (NPY) modulates noradrenergic vasoconstriction in penile ..
  72. ncbi Only activated but not non-activated presynaptic alpha 2-autoreceptors interfere with neighbouring presynaptic receptor mechanisms
    N Limberger
    Pharmakologisches Institut der Universität, Freiburg i Br, Federal Republic of Germany
    Naunyn Schmiedebergs Arch Pharmacol 338:62-7. 1988
    ..Under these conditions, the non-activated presynaptic alpha 2-adrenoceptor does not interfere with presynaptic opioid kappa- and adenosine A1-receptor mechanisms.(ABSTRACT TRUNCATED AT 250 WORDS)..
  73. pmc Effects of L-histidine depletion and L-tyrosine/L-phenylalanine depletion on sensory and motor processes in healthy volunteers
    P van Ruitenbeek
    Department of Neuropsychology and Psychopharmacology, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, The Netherlands
    Br J Pharmacol 157:92-103. 2009
    ..functioning and that histamine H3-receptor antagonists, which increase histaminergic function through presynaptic receptors, improve cognitive performance in models of clinical cognitive deficits...
  74. ncbi GABA(B) presynaptic receptors modulate glycine exocytosis from mouse spinal cord and hippocampus glycinergic nerve endings
    Cristina Romei
    Department of Experimental Medicine, Section of Pharmacology and Toxicology, University of Genoa, Genoa, Italy
    Pharmacol Res 59:154-9. 2009
    Glycine release and modulation of glycine exocytosis by presynaptic receptors have been rarely studied...
  75. ncbi Subtypes Y1 and Y2 of the neuropeptide Y receptor are respectively expressed in pro-opiomelanocortin- and neuropeptide-Y-containing neurons of the rat hypothalamic arcuate nucleus
    C Broberger
    Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    Neuroendocrinology 66:393-408. 1997
    ..Release of NPY, and possible coexisting messengers, may be controlled by presynaptic Y2-R expressed in NPY neurons. Taken together, the findings support the division of Y1-Rs and Y2-Rs into post- and presynaptic receptors, respectively.
  76. ncbi Ultrastructural localization of neuropeptide Y Y1 receptors in the rat medial nucleus tractus solitarius: relationships with neuropeptide Y or catecholamine neurons
    Michael J Glass
    Department of Neurology and Neuroscience, Division of Neurobiology, Weill Medical College of Cornell University, New York, New York 10021, USA
    J Neurosci Res 67:753-65. 2002
    ..Agonists of Y1-R in the mNTS may thus affect cardiovascular regulation by modulating NPY, catecholamine, and excitatory amino acid transmission...
  77. pmc The anti-migraine 5-HT(1B/1D) agonist rizatriptan inhibits neurogenic dural vasodilation in anaesthetized guinea-pigs
    D J Williamson
    Department of Pharmacology, Merck Sharp and Dohme Research Laboratories, Neuroscience Research Centre, Terlings Park, Harlow, Essex, CM20 2QR, UK
    Br J Pharmacol 133:1029-34. 2001
    ..Rizatriptan did not reverse the dural dilation evoked by CGRP indicating an action on presynaptic receptors located on trigeminal sensory fibres innervating dural blood vessels...
  78. ncbi Neuropeptide Y in the dentate gyrus
    Gunther Sperk
    Department of Pharmacology, Medical University Innsbruck, Peter Mayr Str 1a, 6020 Innsbruck, Austria
    Prog Brain Res 163:285-97. 2007
    ..located on granule cell dendrites in the molecular layer and some interneurons, while Y2 receptors are presynaptic receptors mediating inhibition of glutamate release, and potentially that of NPY and GABA depending on their ..
  79. ncbi Cloning and functional expression of the human histamine H3 receptor
    T W Lovenberg
    R W Johnson Pharmaceutical Research Institute, San Diego, California, USA
    Mol Pharmacol 55:1101-7. 1999
    Histamine regulates neurotransmitter release in the central and peripheral nervous systems through H3 presynaptic receptors. The existence of the histamine H3 receptor was demonstrated pharmacologically 15 years ago, yet despite ..
  80. ncbi Impaired drinking response in histamine H3 receptor knockout mice following dehydration or angiotensin-II challenge
    Ryo Yoshimoto
    Tsukuba Research Institute, Banyu Pharmaceutical Co Ltd, Tsukuba, Ibaraki 300 2611, Japan
    Pharmacol Biochem Behav 84:504-10. 2006
    Histamine H3 receptors (H3Rs) are presynaptic receptors that negatively regulate the release of histamine. The present study examined the physiological role of H3Rs in drinking behavior. In water-replete rats, intracerebroventricular (i...
  81. ncbi Hypothermic effect of GABA in conscious stressed rats: its modification by cholinergic agonists and antagonists
    F J Minano
    Departamento de Farmacologia y Terapeutica, Facultad de Medicina, Universidad de Sevilla, Spain
    J Pharm Pharmacol 39:721-6. 1987
    ..Muscarinic receptors may play an important role in the effect of GABA. The results support the hypothesis of nicotinic presynaptic receptors modulating noradrenergic nerve endings that play a part in the hypothermic response of GABA.
  82. ncbi Hallucinogens
    David E Nichols
    Department of Medicinal Chemistry and Molecular Pharmacology, School of Pharmacy and Pharmacal Sciences, Purdue University, West Lafayette, IN 47907 2091, USA
    Pharmacol Ther 101:131-81. 2004
    ..In addition, it appears entirely possible that utility may still emerge for the use of hallucinogens in treating alcoholism, substance abuse, and certain psychiatric disorders...
  83. ncbi Differential sensitivity to blockade by 4-aminopyridine of presynaptic receptors regulating [3H]acetylcholine release from rat hippocampus
    B B Fredholm
    Department of Pharmacology, Karolinska Institutet, Stockholm, Sweden
    J Neurochem 54:1386-90. 1990
    ..Furthermore, the results indicate that presynaptic A1 receptors on hippocampal cholinergic neurons do not primarily regulate 4-AP-dependent potassium channels, but that they might act directly on a Ca2+ conductance...
  84. ncbi Histamine H(3)-receptors: a new frontier in myocardial ischemia
    R Levi
    Department of Pharmacology, Cornell University, Weill Medical College, New York, New York, USA
    J Pharmacol Exp Ther 292:825-30. 2000
    ..Although other presynaptic receptors also modulate NE release from sympathetic nerve endings, H(3)R stimulation reduces both exocytotic and ..
  85. pmc Muscarinic inhibition of [3H]-noradrenaline release on rabbit iris in vitro: effects of stimulation conditions on intrinsic activity of methacholine and pilocarpine
    I T Bognar
    Pharmakologisches Institut der Universität, Mainz, Federal Republic of Germany
    Br J Pharmacol 94:890-900. 1988
    ..The activation by pilocarpine of the presynaptic receptors provides an alternative explanation for the miosis induced in the rabbit in vivo, which might be the ..
  86. ncbi Neuroactive steroid regulation of neurotransmitter release in the CNS: action, mechanism and possible significance
    Ping Zheng
    State Key Laboratory of Medical Neurobiology, Institutes of Brain Science, Shanghai Medical College, Fudan University, Shanghai 200032, People s Republic of China
    Prog Neurobiol 89:134-52. 2009
    ..The mechanisms are also complicated. Many of them involve rapid non-genomic effects on presynaptic receptors and ion channels like sigma-1 receptor, alpha(1) receptor, nicotine receptor, D1 receptor, NMDA receptor, ..
  87. ncbi Receptor-mediated interaction between the sympathetic nervous system and immune system in inflammation
    G Hasko
    Department of Surgery, UMD New Jersey Medical School, Newark 07103, USA
    Neurochem Res 26:1039-44. 2001
    ..Once these transmitters are released, they stimulate both presynaptic receptors on nerve terminals and post-synaptic receptors on immune cells...
  88. pmc Neuritogenic actions of botulinum neurotoxin A on cultured motor neurons
    Julie A Coffield
    Department of Physiology and Pharmacology, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA
    J Pharmacol Exp Ther 330:352-8. 2009
    ..Collectively, these results suggest that binding of BoNT/A to the motor neuronal membrane activates neuritogenesis through as yet undetermined intracellular pathway(s), independent of its known action on vesicular release...
  89. ncbi Functional role of mGluR1 and mGluR4 in pilocarpine-induced temporal lobe epilepsy
    J Pitsch
    Department of Neuropathology, University of Bonn Medical Center, Sigmund Freud Str 25, D 53105 Bonn, Germany
    Neurobiol Dis 26:623-33. 2007
    ..Therefore, our data strongly recommend both mGluRs as potential drug targets to interfere with the development of hippocampal damage and seizure activity in TLE...
  90. ncbi Anatomy of adenosine A2A receptors in brain: morphological substrates for integration of striatal function
    Diane L Rosin
    Department of Pharmacology, University of Virginia Health Sciences Center, Charlottesville, VA 22908 0735, USA
    Neurology 61:S12-8. 2003
    ..In the striatum, terminals expressing A(2A)Rs accounted for 25% of the labeled elements. These presynaptic receptors may facilitate excitatory glutamatergic, inhibitory GABAergic, and possibly cholinergic striatal ..
  91. ncbi Neurexin I alpha is a major alpha-latrotoxin receptor that cooperates in alpha-latrotoxin action
    M Geppert
    Max Planck Institut fur experimentelle Medizin, Gottingen, Germany
    J Biol Chem 273:1705-10. 1998
    alpha-Latrotoxin is a potent neurotoxin from black widow spider venom that binds to presynaptic receptors and causes massive neurotransmitter release...
  92. ncbi Adenosine modulation of amino acid release in rat hippocampus during ischemia and veratridine depolarization
    A Heron
    Laboratoire de Recherches Cerebrovasculaires, UA 641 CNRS, Universite Paris VII, France
    Brain Res 608:27-32. 1993
    ..to determine whether endogenous adenosine modulates 'in vivo' neurotransmitter amino acid release via its presynaptic receptors. Two conditions were compared: neuronal depolarization by local infusion of veratridine (600 microM), and ..
  93. ncbi Effects of VPAC2 receptor activation on membrane excitability and GABAergic transmission in subparaventricular zone neurons targeted by suprachiasmatic nucleus
    M L H J Hermes
    Neurosciences, Ottawa Hospital Research Institute and University of Ottawa, 725 Parkdale Avenue, Ottawa, Ontario, Canada K1Y 4E9
    J Neurophysiol 102:1834-42. 2009
    ..This, together with an increase in frequency of spontaneous and miniature IPSCs, implies the presence of presynaptic receptors that facilitate GABA release from SCN and possibly other synaptic terminals...
  94. ncbi Hemicholinium-3 facilitates the release of acetylcholine by acting on presynaptic nicotinic receptors at a central synapse in Aplysia
    B Poulain
    Laboratoire de Neurobiologie Cellulaire et Moleculaire, C N R S, Gif sur Yvette, France
    Brain Res 435:63-70. 1987
    ..was prevented by tubocurarine or hexamethonium, pointing to an agonistic action of HC-3 on nicotinic presynaptic receptors implicated in a positive feedback on ACh release...
  95. ncbi Possible mechanisms of the effect of physostigmine on the facilitation of acetylcholine release in the guinea pig myenteric plexus
    A Mike
    Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest
    Brain Res Bull 34:441-5. 1994
    ..We made an effort to clear up the mechanism of this facilitation by blocking possible nicotinic presynaptic receptors, by excluding the alpha 2-adrenoceptor-mediated masking effect of noradrenergic heteromodulation, by ..
  96. ncbi Distribution of D1 and D5 dopamine receptors in the primate nucleus accumbens
    E C Muly
    Atlanta Department of Veterans Affairs Medical Center, Decatur, GA, USA
    Neuroscience 169:1557-66. 2010
    ..This suggests differences in how receptor is translated and distributed in D(1) mRNA expressing medium spiny neurons in the NAc and caudate...
  97. pmc Catecholamine outflow from mouse and rat brain slice preparations evoked by nicotinic acetylcholine receptor activation and electrical field stimulation
    P Scholze
    Center for Brain Research, Medical University of Vienna, Vienna, Austria
    Br J Pharmacol 151:414-22. 2007
    ..We have now used brain slices to investigate nicotine-induced catecholamine outflow in wild type (WT) and nAChR (beta2 and alpha5) knockout mice for a comparison with rat brain slice preparations...
  98. ncbi Modulation by group I mGLU receptor activation and group III mGLU receptor blockade of locomotor responses induced by D1-like and D2-like receptor agonists in the nucleus accumbens
    Christophe Rouillon
    UMR CI NAPS 6232, Universite de Caen, CNRS, CEA, Centre Cyceron, BP 5229 Boulevard Becquerel, 14074 Caen Cedex, France
    Brain Res 1198:44-54. 2008
    ..mediated by D1-like receptors and by D2-like postsynaptic receptors and inhibited that induced by D2-like presynaptic receptors. These results compiled with previous data demonstrate that group I mGlu receptors and group III mGlu ..
  99. ncbi Effects of alpha-erabutoxin, alpha-bungarotoxin, alpha-cobratoxin and fasciculin on the nicotine-evoked release of dopamine in the rat striatum in vivo
    F Dajas-Bailador
    Neurochemistry Division, Instituto de Investigaciones Biologicas Clemente Estable, Montevideo, Uruguay
    Neurochem Int 33:307-12. 1998
    ..This interaction of short neurotoxin polypeptides and presynaptic receptors may permit the further elucidation of the particular nicotinic receptor populations responsible for the ..
  100. ncbi [Central presynaptic receptors]
    E A Singer
    Pharmakologisches Institut, Universitat Wien
    Wien Klin Wochenschr 102:609-15. 1990
    ..but, in addition, easily measurable, which makes this method of stimulation very suitable for analyses at presynaptic receptors. By using this approach it became possible, for the first time, to determine dissociation constants of ..
  101. ncbi Chronic and acute regulation of Na+/Cl- -dependent neurotransmitter transporters: drugs, substrates, presynaptic receptors, and signaling systems
    N R Zahniser
    Department of Pharmacology, C 236, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Denver, CO 80262, USA
    Pharmacol Ther 92:21-55. 2001
    ....

Research Grants62

  1. NEURONAL CONTROL OF CGRP GENE EXPRESSION
    ANDREW RUSSO; Fiscal Year: 2009
    ..We propose to test the hypothesis that cytokines create a positive feedback loop onto presynaptic receptors to stimulate CGRP gene expression in the trigeminal ganglion...
  2. G PROTEIN STRUCTURE AND FUNCTION
    Heidi E Hamm; Fiscal Year: 2010
    ..b>Presynaptic receptors (auto- or hetero-receptors for 5HT, dopamine, acetylcholine, glutamate, etc...
  3. Effects of mGluR2/3 Activation on Cue-Induced Cocaine Relapse in Squirrel Monkeys
    Daniel F Manvich; Fiscal Year: 2010
    ..Group II mGluRs include the mGluR2 and mGluRS subtypes and are Gi/o-coupled presynaptic receptors whose activation results in decreased synaptic release of glutamate, dopamine, and other neurotransmitters...
  4. Presynaptic receptors and analog signaling in the CNS
    Craig E Jahr; Fiscal Year: 2013
    ..sites is regulated by several factors including the frequency of action potentials and the activity of presynaptic receptors. In addition to these mechanisms, subthreshold depolarizations of the somatodendritic compartment recently ..
  5. Synapse Remodeling and Neuronal MHC Class I
    Carla J Shatz; Fiscal Year: 2013
    ..model for neuronal MHCI suggests that MHCI protein located postsynaptically binds across the synapse to presynaptic receptors such as PirB. Immunostaining with MHCI antibodies will be used to examine synaptic distribution...
  6. Mechanisms of Presynaptic Plasticity in Visual Cortex
    Benjamin D Philpot; Fiscal Year: 2011
    ..These presynaptic receptors are involved in regulating neurotransmitter release and long-term depression (LTD) of synaptic strength...
  7. Characterization and Use of Fluorescent Endocannabinoid Transporter Substrates
    Michael Kavanaugh; Fiscal Year: 2009
    Endocannabinoids are released in the brain in response to synaptic activity and they interact with presynaptic receptors in a retrograde fashion to inhibit release of transmitter...
  8. Regulation of release probability by tonic presynaptic inhibition
    MONICA SHISHIR THANAWALA; Fiscal Year: 2013
    ..important for setting initial p? This project will test the hypothesis that tonic inhibition by multiple presynaptic receptors produces a large reduction in initial p...
  9. CHOLINERGIC PHARMACOLOGY OF BASAL FOREBRAIN NEURONS
    Susan Robinson; Fiscal Year: 1990
    ..so that cholinergic neurotransmission can be effectively enhanced by cholinergic antagonists which block presynaptic receptors but not postsynaptic receptors...
  10. G protein-mediated modulation of synaptic vesicle fusion
    Simon T Alford; Fiscal Year: 2010
    ..Finally, we will investigate the affect of presynaptic G proteins on the properties of individual synaptic contacts using high-speed imaging techniques. ..
  11. PSYCHOMOTOR STIMULANTS AND ADRENERGIC NERVE FUNCTION
    Charles Smith; Fiscal Year: 1991
    b>Presynaptic receptors are thought to be important in the regulation of transmitter release from a variety of neurons...
  12. MECHANISM OF ACTION OF DRUGS OF ABUSE--AMPHETAMINE
    Ronald Kuczenski; Fiscal Year: 2004
    ..The possibility of nonsynaptic release sites on nigrostriatal DA afferents will be assessed by labeling components of the release mechanism and then correlating them with the locations of dopamine receptors. ..
  13. PRE & POSTSYNAPTIC NICOTINIC ACHRS--STRUCTURE & FUNCTION
    Peter Sargent; Fiscal Year: 1999
    ..Should presynaptic receptors be found in the ciliary ganglion, we will attempt to characterize these receptors functionally by patch ..
  14. NEURONAL CALCIUM CURRENT ALTERATIONS IN HYPERTENSION
    STEPHEN IKEDA; Fiscal Year: 1993
    ..It is hoped that the proposed study will help fill this void in our understanding of the pathobiology of hypertension and provide a basis for the development of improved antihypertensive agents...
  15. NMDA RECEPTOR IN LEAD INDUCED COGNITIVE DEFICIT
    EDSON ALBUQUERQUE; Fiscal Year: 1999
    ..neurotransmitters, it is critical to determine whether Pb2+ alters transmitter release by acting at these presynaptic receptors. Therefore, the effects of Pb2+ on spontaneous and evoked transmitter release will be investigated at the ..
  16. NOVEL MODES OF ACTION OF ABUSED DRUGS
    PHILIP GROVES; Fiscal Year: 2001
    ....
  17. VASCULAR SYMPATHETIC NERVE FUNCTION IN HEART FAILURE
    Robert Zelis; Fiscal Year: 1990
    ..Since high NE levels may cause CHF to progress, knowledge of how and why NE levels are high may suggest ways to interrupt the process...
  18. REGULATION OF TRANSMITTER RELEASE IN THE DORSAL HORN
    AMY MACDERMOTT; Fiscal Year: 2001
    ..Activation of presynaptic receptors on the DRG nerve terminal has been postulated to account for one critical level of control of synaptic ..
  19. ETHNIC DIFFERENCES IN AUTONOMIC CARDIOVASCULAR CONTROL
    Alastair Wood; Fiscal Year: 2000
    ..By defining the factors contributing to the altered cardiovascular response in African-Americans, physicians will be better able to tailor therapy to this group and reduce their present excessive burden of cardiovascular disease. ..
  20. CONFERENCE ON PRESYNAPTIC RECEPTORS
    Stanley Kalsner; Fiscal Year: 1990
    ..The identification of presynaptic receptors has led to a spate of hypotheses relevant to disease processes and to conditions as diverse as psychosis, ..
  21. REGULATION OF TRANSMISSION BY PRESYNAPTIC RECEPTORS
    DANIEL MCGEHEE; Fiscal Year: 1999
    ....
  22. DRUGS OF ABUSE--DOPAMINE RELEASE AND REUPTAKE
    JAMES SCHENK; Fiscal Year: 1999
    ..Furthermore, a strong correlation between the binding of drugs of abuse to the rat dopaminergic transporter and the induction of self-administration behaviors has been made. ..
  23. VASCULAR ACTIONS OF PTH IN HEALTH AND DISEASE
    GEORGE NICKOLS; Fiscal Year: 1990
    ..The results of these studies will provide basic information concerning the involvement of PTH in the biochemical processes which control blood vessel tone in physiological and pathological conditions...
  24. PRESYNAPTIC RECEPTORS ON EMBRYONIC SENSORY NEURONS
    Kathleen Dunlap; Fiscal Year: 2007
    ..g., allodynia and hypersensitivity- identifying mechanisms that control Ca2+ influx in sensory neurons may allow development of new therapeutic strategies to treat chronic pain. ..
  25. Development of Imaging Technique to Study Regulation
    VLADISLAV VERKHUSHA; Fiscal Year: 2006
    ..PAFPs to analyze regulation of the DAT trafficking by physical or signal mediated interactions with D2 presynaptic receptors (Aim 3)...
  26. AGE, AXON INJURY AND MOTOR NEURON SYNAPTOLOGY
    DEBORAH VAUGHAN; Fiscal Year: 1993
    ..Receptor dynamics will be correlated with binding to serotonin and noradrenalin uptake sites and presynaptic receptors. These studies will establish a bridge between the results of anatomical, immunocytochemical and ..
  27. MOLECULAR ANALYSIS OF OLFACTORY PRESYNAPIC RECEPTORS
    Bettye Hollins; Fiscal Year: 2004
    ..The results of this study will establish the molecular identity of the presynaptic receptors inhibiting the output of ORNs in the olfactory system of the lobster and will provide the preliminary data ..
  28. Brainstem Gustatory Nuclei- Circuits & Neurotransmitters
    Thomas Finger; Fiscal Year: 2007
    ..The second aim relies on functional imaging and immunocytochemistry to determine whether GABA acts via presynaptic receptors to modulate primary gustatory inputs...
  29. Presynaptic Receptor Complexes
    THOMAS SUDHOF; Fiscal Year: 2007
    ..This research will be performed primarily in Russia at the Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry in collaboration with Alexander Petrenko as an extension of NIH grant R37 MH5280. [unreadable] [unreadable]..
  30. A Proteomic Analysis of the Norepinephrine Transporter
    Uhna Sung; Fiscal Year: 2007
    ..Stimulation of presynaptic receptors linked to pathways involving second messengers, kinases and phosphatases regulate the activity of NET by ..
  31. AMINE TRANSPORTERS--TRAFFICKING AND REGULATION
    MICHAEL QUICK; Fiscal Year: 2000
    ..g., Ca2+) or that signal extracellular transmitter levels (e.g., presynaptic receptors). The mechanism of action (e.g., protein synthesis, translocation) will be assessed for each modulator...
  32. Presynaptic Ionotropic Glutamate Receptors in Somethesis
    Aldo Rustioni; Fiscal Year: 2007
    ..the AMPA, kainate and NMDA, we will answer specific questions addressing the possible functional role of presynaptic receptors. These questions and the strategies to answer them are now specifically listed throughout the text and ..
  33. Interaction of Botulinum neurotoxins with presynaptic receptor complexes
    Michael Baldwin; Fiscal Year: 2008
    ..Similarly, receptor identification will expand the impact of these studies beyond biodefense, by contributing to improved clinical therapeutic protocols that utilize the BoNTs. [unreadable] [unreadable] [unreadable]..
  34. Dynamic imaging of synaptic inhibition in the brain
    George Augustine; Fiscal Year: 2009
    ..abstract_text> ..
  35. INTRACELLULAR SIGNALS FOR LONG TERM SYNAPTIC DEPRESSION
    George Augustine; Fiscal Year: 2002
    ....
  36. Dynamic Imaging of Synaptic Inhibition
    George Augustine; Fiscal Year: 2002
    ..abstract_text> ..
  37. CALCIUM IONS AND PRESYNAPTIC FUNCTION
    George Augustine; Fiscal Year: 2009
    ....
  38. Transmission at Synapsin-deficient Synapses
    George Augustine; Fiscal Year: 2006
    ..abstract_text> ..
  39. BIOLOGY OF SEROTONIN IN BRAIN
    Irwin Lucki; Fiscal Year: 2006
    ..The results of the proposed work should have important implications for our understanding of synaptic transmission in the brain and of the effect of psychotherapeutic drugs...
  40. Dopamine Mechanisms and Receptors in Raphe 5-HT Neurons
    Samir Haj Dahmane; Fiscal Year: 2004
    ....
  41. CENTRAL BAROREFLEX MECHANISMS OF ANESTHETIC ACTION
    MICHAEL ANDRESEN; Fiscal Year: 2006
    ..By examining different anesthetics, we may also better understand whether potentially new anesthetics might be designed to spare these cardioregulatory sites. [unreadable] [unreadable]..
  42. DOPAMINE NEUROTRANSMISSION IN EXPERIMENTAL PARKINSONISM
    PAUL GARRIS; Fiscal Year: 2005
    ..Moreover, L-DOPA is associated with adverse side effects after extended use, apparently due to non-physiological dopamine replacement. However, how L-DOPA acts on dopaminergic signaling is not completely established. ..
  43. Transgenic Mouse Model to Address Heterogeneity in Autism Spectrum Disorders
    RANDY DEAN BLAKELY; Fiscal Year: 2010
    ..Based on exciting preliminary evidence that mice expressing Ala56 SERT exhibit multiple behavioral and biochemical phenotypes, we propose a two-year project to extend our studies and dissect the impact of SERT hyperfunction in vivo. ..
  44. REGULATION OF SEROTONIN TRANSPORTERS
    Randy D Blakely; Fiscal Year: 2010
    ....
  45. Changes/SNARE Proteins/Neural Transmission/FRET
    Robert Zucker; Fiscal Year: 2005
    ..Success will open wide possibilities for the study of dynamic changes in protein structure during a variety of cell activities, and pave the way for the study of protein structural alterations in diseased tissue. ..
  46. Identification of a novel bioactive peptide
    Hans Peter Nothacker; Fiscal Year: 2004
    ..The BRS-3 ligands will prove as an invaluable tool to answer the functional significance and understand the physiological role of the BRS-3 system in the regulation of energy balance. ..
  47. Developmental Affects of Ritalin on Brain
    TERESA MILNER; Fiscal Year: 2004
    ..Determining how therapeutic dosage regimens effect these transmitter systems is critical in understanding the safety of long-term therapeutic doses of MPH administered to children and adolescents with ADHD and other related disorders. ..
  48. PLASTICITY AT A CRAYFISH NEUROMUSCULAR SYNAPSE
    Jen Wei Lin; Fiscal Year: 2003
    ....
  49. CENTRAL NEURONAL MECHANISMS--DECOMPENSATED HEMORRHAGE
    PATRICE GUYENET; Fiscal Year: 2003
    ..Understanding the neurophysiological mechanisms triggered by hypotensive hemorrhage should lead to improved ability to manage this all too frequent clinical problem. ..
  50. Mechanisms of Amphetamine Action on Dopaminergic Signaling
    PAUL GARRIS; Fiscal Year: 2007
    ..New microsensor technology will be employed in laboratory animals to characterize amphetamine's effect on brain chemistry related to learning and motivaton. [unreadable] [unreadable] [unreadable]..
  51. Dynamic fMRI to measure neuronal activity
    PAUL MACIEJEWSKI; Fiscal Year: 2006
    ..The outcomes of this basic research are expected to be relevant to diagnostic evaluation in neurology and psychiatry. ..
  52. MOP Receptor Effects on the Hippocampal CA1 Network
    ADAM MCQUISTON; Fiscal Year: 2008
    ..The results from these studies will provide important information regarding MOP receptor-induced changes in network activity and may possibly lead to the development of treatments for opioid addiction. ..
  53. High-Throughput Assay for G-Protein Coupled Receptors in Pain Research
    Olivier Civelli; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  54. SEROTONIN RECEPTOR REGULATION AND BEHAVIOR
    Irwin Lucki; Fiscal Year: 2003
    ..The results of the proposed work should have important implications for our understanding of the mechanisms involved in the behavioral effects of SSRIs in the clinical treatment of depression. ..
  55. Presynaptic Mechanisms of Neurotransmission in NTS
    MICHAEL ANDRESEN; Fiscal Year: 2009
    ..The different sub classes of afferent nerve terminal will be also be compared in terms of their control of glutamate release and modulation by peptides. ..
  56. Kainate Receptors on Hippocampal Interneurons
    Matthew Frerking; Fiscal Year: 2007
    ..abstract_text> ..
  57. PRESYNAPTIC LONG-TERM SYNAPTIC DEPRESSION
    PATRIC STANTON; Fiscal Year: 2008
    ..The long-term regulation of transmitter release has far-reaching importance to normal synaptic processing dynamics, and controlling pathologic glutamate release during injury or disease. ..
  58. Excellence in Cardiovascular Sciences Summer Research
    Debra Diz; Fiscal Year: 2007
    ..Moreover, all students regarded the experience as a positive influence on their career and 76% of those who responded said they plan to pursue some aspect of biomedical research as a career. ..