neurokinin 1 receptors

Summary

Summary: A class of cell surface receptors for tachykinins with a preference for substance P. Neurokinin-1 (NK-1) receptors have been cloned and are members of the G protein coupled receptor superfamily. They are found on many cell types including central and peripheral neurons, smooth muscle cells, acinar cells, endothelial cells, fibroblasts, and immune cells.

Top Publications

  1. ncbi A key role of neurokinin 1 receptors in acute pancreatitis and associated lung injury
    Hon Yen Lau
    Department of Pharmacology, National University of Singapore, Singapore
    Biochem Biophys Res Commun 327:509-15. 2005
  2. ncbi Disinhibition opens the gate to pathological pain signaling in superficial neurokinin 1 receptor-expressing neurons in rat spinal cord
    Carole Torsney
    Department of Physiology and Cellular Biophysics, Center for Neurobiology and Behavior, Columbia University, New York, New York 10032, USA
    J Neurosci 26:1833-43. 2006
  3. ncbi Persistent pain produces stress-like alterations in hippocampal neurogenesis and gene expression
    Vanja Duric
    Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, KS 66160, USA
    J Pain 7:544-55. 2006
  4. ncbi Substance P: a pioneer amongst neuropeptides
    T Hokfelt
    Department of Neuroscience, and Department of Clinical Physiology, Karolinska Institutet, S 17177 Stockholm, Sweden
    J Intern Med 249:27-40. 2001
  5. ncbi Projection neurons in lamina I of rat spinal cord with the neurokinin 1 receptor are selectively innervated by substance p-containing afferents and respond to noxious stimulation
    Andrew J Todd
    Spinal Cord Group, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ, United Kingdom
    J Neurosci 22:4103-13. 2002
  6. ncbi Spinal neurons that possess the substance P receptor are required for the development of central sensitization
    Sergey G Khasabov
    Department of Preventive Sciences, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Neurosci 22:9086-98. 2002
  7. ncbi The role of substance P in stress and anxiety responses
    K Ebner
    Department of Pharmacology and Toxicology, Institute of Pharmacy, Center for Molecular Biosciences Innsbruck, University of Innsbruck, Innsbruck, Austria
    Amino Acids 31:251-72. 2006
  8. ncbi Aprepitant: a review of its use in the prevention of chemotherapy-induced nausea and vomiting
    Toni M Dando
    Adis International Limited, 41 Centorian Drive, PB 65901, Mairangi Bay, Auckland, New Zealand
    Drugs 64:777-94. 2004
  9. ncbi Tachykinins regulate the function of platelets
    Gwenda J Graham
    School of Animal and Microbial Sciences, The University of Reading, Whiteknights, Reading, Berkshire, RG6 6AJ, UK
    Blood 104:1058-65. 2004
  10. ncbi Human monocytes and macrophages express substance P and neurokinin-1 receptor
    W Z Ho
    Division of Immunologic and Infectious Diseases, Joseph Stokes Jr Research Institute at The Children s Hospital of Philadelphia, PA 19104, USA
    J Immunol 159:5654-60. 1997

Detail Information

Publications284 found, 100 shown here

  1. ncbi A key role of neurokinin 1 receptors in acute pancreatitis and associated lung injury
    Hon Yen Lau
    Department of Pharmacology, National University of Singapore, Singapore
    Biochem Biophys Res Commun 327:509-15. 2005
    ..Pulmonary microvascular permeability was also reduced as a result of CP-96345 treatment. These results point to a key role of NK1 receptors in acute pancreatitis and associated lung injury...
  2. ncbi Disinhibition opens the gate to pathological pain signaling in superficial neurokinin 1 receptor-expressing neurons in rat spinal cord
    Carole Torsney
    Department of Physiology and Cellular Biophysics, Center for Neurobiology and Behavior, Columbia University, New York, New York 10032, USA
    J Neurosci 26:1833-43. 2006
    ..These disinhibition-induced changes, in particular the novel polysynaptic low-threshold input onto lamina I NK1R+ neurons, may be an underlying component of the hypersensitivity present in chronic pain states...
  3. ncbi Persistent pain produces stress-like alterations in hippocampal neurogenesis and gene expression
    Vanja Duric
    Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, KS 66160, USA
    J Pain 7:544-55. 2006
    ....
  4. ncbi Substance P: a pioneer amongst neuropeptides
    T Hokfelt
    Department of Neuroscience, and Department of Clinical Physiology, Karolinska Institutet, S 17177 Stockholm, Sweden
    J Intern Med 249:27-40. 2001
    ....
  5. ncbi Projection neurons in lamina I of rat spinal cord with the neurokinin 1 receptor are selectively innervated by substance p-containing afferents and respond to noxious stimulation
    Andrew J Todd
    Spinal Cord Group, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ, United Kingdom
    J Neurosci 22:4103-13. 2002
    ..We conclude that presence or absence of the NK1 receptor is a better indicator of function than morphology for lamina I projection neurons in the rat...
  6. ncbi Spinal neurons that possess the substance P receptor are required for the development of central sensitization
    Sergey G Khasabov
    Department of Preventive Sciences, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Neurosci 22:9086-98. 2002
    ..It appears that this relatively small population of neurons can regulate the physiological properties of other nociceptive neurons and drive central sensitization...
  7. ncbi The role of substance P in stress and anxiety responses
    K Ebner
    Department of Pharmacology and Toxicology, Institute of Pharmacy, Center for Molecular Biosciences Innsbruck, University of Innsbruck, Innsbruck, Austria
    Amino Acids 31:251-72. 2006
    ..Preclinical and clinical studies have found evidence in favour of such an assumption. The status of this research is reviewed here...
  8. ncbi Aprepitant: a review of its use in the prevention of chemotherapy-induced nausea and vomiting
    Toni M Dando
    Adis International Limited, 41 Centorian Drive, PB 65901, Mairangi Bay, Auckland, New Zealand
    Drugs 64:777-94. 2004
    ..Despite marked advances in the prevention of CINV, standard therapy does not protect all patients. The addition of aprepitant to standard therapy provides an advance in the prevention of both acute and delayed CINV in adults with cancer...
  9. ncbi Tachykinins regulate the function of platelets
    Gwenda J Graham
    School of Animal and Microbial Sciences, The University of Reading, Whiteknights, Reading, Berkshire, RG6 6AJ, UK
    Blood 104:1058-65. 2004
    ..Together our data implicate tachykinins, specifically SP and EKA/B, in the regulation of platelet function...
  10. ncbi Human monocytes and macrophages express substance P and neurokinin-1 receptor
    W Z Ho
    Division of Immunologic and Infectious Diseases, Joseph Stokes Jr Research Institute at The Children s Hospital of Philadelphia, PA 19104, USA
    J Immunol 159:5654-60. 1997
    ..The demonstration that human monocytes and macrophages express substance P and its receptor support the notion that substance P is biologically involved in regulating the functions of these cells in an autocrine fashion...
  11. pmc Substance P stimulates cyclooxygenase-2 and prostaglandin E2 expression through JAK-STAT activation in human colonic epithelial cells
    Hon Wai Koon
    Gastrointestinal Neuropeptide Center, Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    J Immunol 176:5050-9. 2006
    ..Our results demonstrate that SP stimulates COX-2 expression and PGE2 production in human colonocytes via activation of the JAK2-STAT3/5 pathway...
  12. ncbi Postsynaptic dorsal column neurons express NK1 receptors following colon inflammation
    J Palecek
    Department of Anatomy and Neuroscience, Marine Biomedical Institute, The University of Texas Medical Branch, Galveston, TX 77555 1069, USA
    Neuroscience 116:565-72. 2003
    ..The presence of immunoreactivity for neurokinin 1 receptors on these postsynaptic dorsal column neurons was examined under control conditions and after colon ..
  13. pmc Phosphorylation of ERK in neurokinin 1 receptor-expressing neurons in laminae III and IV of the rat spinal dorsal horn following noxious stimulation
    Erika Polgár
    Spinal Cord Group, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK
    Mol Pain 3:4. 2007
    ..The stimuli were mechanical (repeated pinching), thermal (immersion in water at 52 degrees C) or chemical (injection of 2% formaldehyde)...
  14. pmc Neurokinin 1 receptors regulate morphine-induced endocytosis and desensitization of mu-opioid receptors in CNS neurons
    Y Joy Yu
    Program in Neuroscience, University of California at San Francisco, San Francisco, California 94158 2140, USA
    J Neurosci 29:222-33. 2009
    ..MORs are coexpressed with neurokinin 1 receptors (NK1Rs) in several regions of the CNS that control opioid dependence and reward...
  15. ncbi Molecular evidence that granuloma T lymphocytes in murine schistosomiasis mansoni express an authentic substance P (NK-1) receptor
    G A Cook
    Department of Animal Health and Biomedical Sciences, University of Wisconsin, Madison 53706
    J Immunol 152:1830-5. 1994
    ..CD4+ granuloma T lymphocytes, purified by FACS, express NK-1 receptor mRNA. Normal liver devoid of granulomas exhibited none of the three tachykinin receptor subclasses...
  16. ncbi Altered nociception, analgesia and aggression in mice lacking the receptor for substance P
    C De Felipe
    Instituto de Neurociencias, Universidad Miguel Hernandez, Alicante, Spain
    Nature 392:394-7. 1998
    ....
  17. ncbi Synaptic plasticity in spinal lamina I projection neurons that mediate hyperalgesia
    Hiroshi Ikeda
    Institute of Physiology and Pathophysiology, Heidelberg University, D 69120 Heidelberg, Germany
    Science 299:1237-40. 2003
    ..Thereby, memory traces of painful events are retained...
  18. ncbi Neurokinin-1 receptor enhances TRPV1 activity in primary sensory neurons via PKCepsilon: a novel pathway for heat hyperalgesia
    Hua Zhang
    Institute of Neurobiology, Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai 200032, China
    J Neurosci 27:12067-77. 2007
    ..These results reveal a novel mechanism of NK-1 in primary sensory neurons via a possible autocrine and paracrine action of SP. Activation of NK-1 in these neurons induces heat hyperalgesia via PKCepsilon-mediated potentiation of TRPV1...
  19. ncbi Involvement of spinal tachykinin NK1 and NK2 receptors in detrusor hyperreflexia during chemical cystitis in anaesthetized rats
    A Lecci
    Pharmacology Research Department Menarini Pharmaceuticals, Florence, Italy
    Eur J Pharmacol 259:129-35. 1994
    ..abstract truncated at 250 words)..
  20. ncbi Identification, localization and receptor characterization of novel mammalian substance P-like peptides
    Marc M Kurtz
    Department of Immunology Rheumatology, Merck Research Laboratories, Rahway, NJ 07065, USA
    Gene 296:205-12. 2002
    ..The results indicate that PPT-C encodes another high affinity ligand of the NK1 receptor which may play an important role in mediating some of the physiological roles previously assigned to the NK1 receptor...
  21. ncbi Prevention of cisplatin-induced acute and delayed emesis by the selective neurokinin-1 antagonists, L-758,298 and MK-869
    Simon Van Belle
    Oncologisch Centrum, Universitair Ziekenhuis, Gent, Belgium
    Cancer 94:3032-41. 2002
    ....
  22. ncbi 5-hydroxytryptamine (5-HT)1A autoreceptor adaptive changes in substance P (neurokinin 1) receptor knock-out mice mimic antidepressant-induced desensitization
    N Froger
    Institut National de la Sante et de la Recherche Medicale U288, NeuroPsychoPharmacologie Moléculaire, Cellulaire et Fonctionnelle, Faculté de Médecine Pitié Salpêtrière, 75013 Paris, France
    J Neurosci 21:8188-97. 2001
    ..Double immunocytochemical labeling experiments suggest that such a heteroregulation of 5-HT(1A) autoreceptors in NK1-/- mutants does not reflect the existence of direct NK1-5-HT(1A) receptor interactions in normal mice...
  23. ncbi A quantitative and morphological study of projection neurons in lamina I of the rat lumbar spinal cord
    R C Spike
    Spinal Cord Group, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ, United Kingdom
    Eur J Neurosci 18:2433-48. 2003
    ..These results suggest that many lamina I cells project to more than one site in the brain and that those projecting to PAG may represent a distinct subclass of lamina I projection neuron...
  24. ncbi Contribution of neurokinin 1 receptors in the cutaneous orofacial inflammatory pain
    Philippe Luccarini
    INSERM E 0216, Neurobiologie de la douleur trigeminale, Faculte de Chirurgie Dentaire, 11 Boulevard Charles de Gaulle, 63000, Clermont Ferrand, France
    Naunyn Schmiedebergs Arch Pharmacol 368:320-3. 2003
    This study investigated the role of neurokinin 1 receptors (NK1R) in inflammatory cutaneous orofacial pain...
  25. ncbi PET evaluation of the uptake of N-[11C]methyl CP-643,051, an NK1 receptor antagonist, in the living porcine brain
    D Bender
    PET Centre, Aarhus University Hospitals, Aarhus, Denmark
    Nucl Med Biol 31:699-704. 2004
    ..We conclude that of N-[11C]methyl CP-643,051 may serve as a lead structure for the development of PET NK-1 ligands of higher specific binding in vivo...
  26. ncbi Primary afferent tachykinins are required to experience moderate to intense pain
    Y Q Cao
    Department of Anatomy, W M Keck Foundation Center for Integrative Neuroscience, University of California San Francisco, 94143 0452, USA
    Nature 392:390-4. 1998
    ..We conclude that the release of tachykinins from primary afferent pain-sensing receptors (nociceptors) is required to produce moderate to intense pain...
  27. ncbi Hippocampal neurokinin-1 receptor and brain-derived neurotrophic factor gene expression is decreased in rat models of pain and stress
    V Duric
    Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, 3901 Rainbow Boulevard, Mail Stop 1018, Kansas City, KS 66160, USA
    Neuroscience 133:999-1006. 2005
    ..These data may provide useful markers of hippocampal activation during chronic pain, and suggest similarities in the mechanisms underlying chronic pain and depression...
  28. ncbi Time-course of the internalization and recycling of neurokinin 1 receptors in rat dorsal horn neurons
    Xueren Wang
    Neuroenteric Disease Program, CURE Digestive Diseases Research Center, Department of Medicine, University of California at Los Angeles, 90095, USA
    Brain Res 944:239-47. 2002
    ..These results show that NK1R internalization and recycling are considerably faster in dorsal horn neurons than in cultured cells, and that most NK1Rs in dorsal horn neurons are internalized when NK1R-mediated hyperalgesia is more severe...
  29. pmc Impact of substance P receptor antagonism on the serotonin and norepinephrine systems: relevance to the antidepressant/anxiolytic response
    Pierre Blier
    University of Ottawa Institute of Mental Health Research, Ottawa, ON
    J Psychiatry Neurosci 29:208-18. 2004
    ..Taken together, these observations strongly suggest that NK1 antagonists could become a new class of antidepressant and anxiolytic agents...
  30. ncbi Synthesis and characterization of a potent, selective, radiolabeled substance-P antagonist for NK1 receptor quantitation: ([18F]SPA-RQ)
    Olof Solin
    Turku PET Centre, Turku, Finland
    Mol Imaging Biol 6:373-84. 2004
    ..To develop and characterize a radiolabelled Substance-P antagonist useful for quantitation of neurokinin-1 receptors in the brain via PET imaging...
  31. ncbi Partial sciatic nerve injury in the mouse as a model of neuropathic pain: behavioral and neuroanatomical correlates
    A B Malmberg
    Department of Anatomy, W M Keck Foundation Center for Integrative Neuroscience, University of California, San Francisco 94143 0452, USA
    Pain 76:215-22. 1998
    ..These results establish a valuable model for future studies of the biochemical basis of neuropathic pain in mice with specific gene modifications...
  32. pmc Neuropeptides activate human mast cell degranulation and chemokine production
    Marianna Kulka
    National Research Council Canada, Room 432, 550 University Avenue, Charlottetown, PE, Canada
    Immunology 123:398-410. 2008
    ..These results are likely to have direct relevance to neuronally induced inflammatory diseases...
  33. ncbi Inhibition of hyperalgesia by ablation of lamina I spinal neurons expressing the substance P receptor
    P W Mantyh
    Molecular Neurobiology Laboratory 151, Veterans Administration Medical Center, Minneapolis, MN 55417, USA
    Science 278:275-9. 1997
    ..Thus, lamina I spinal cord neurons that express the substance P receptor play a pivotal role in the transmission of highly noxious stimuli and the maintenance of hyperalgesia...
  34. ncbi Neurogenic amplification of immune complex inflammation
    C R Bozic
    Perlmutter Laboratory, Children s Hospital, 300 Longwood Avenue, Boston, MA 02115, USA
    Science 273:1722-5. 1996
    ..Immunoreactive substance P was measurable in fluids lining the lung at time points before neutrophil influx and may thus be involved in an early step in the inflammatory response to immune complexes in the lung...
  35. ncbi Superficial NK1-expressing neurons control spinal excitability through activation of descending pathways
    Rie Suzuki
    Department of Pharmacology, University College London, Gower Street, London WC1E 6BT, UK
    Nat Neurosci 5:1319-26. 2002
    ....
  36. ncbi Neurokinin-1 receptor-expressing neurons in the amygdala modulate morphine reward and anxiety behaviors in the mouse
    Christopher A Gadd
    Department of Anatomy and Developmental Biology, University College London, London, WC1E 6BT, United Kingdom
    J Neurosci 23:8271-80. 2003
    ....
  37. pmc Expression of functional NK1 receptors in human alveolar macrophages: superoxide anion production, cytokine release and involvement of NF-kappaB pathway
    Claudio Bardelli
    Department of Medical Sciences, School of Medicine, University of Piemonte Orientale A Avogadro, Via Solaroli, 17, 28100 Novara, Italy
    Br J Pharmacol 145:385-96. 2005
    ..5 These results clearly indicate that human AMs possess functional NK-1R on their surface, which are upregulated in healthy smokers, providing new insights on the mechanisms involved in tobacco smoke toxicity...
  38. ncbi Substance P and neurokinin A mediate sensory synaptic transmission in young rat dorsal horn neurons
    P Li
    Department of Anesthesiology, Washington University Pain Center, Washington University School of Medicine, St. Louis, MO 63110, USA
    Brain Res Bull 55:521-31. 2001
    ..The present study provides electrophysiological evidence that suggests the possible contribution of SP and NKA to sensory synaptic transmission between primary afferent fibers and dorsal horn neurons...
  39. ncbi Disruption of noradrenergic transmission and the behavioural response to a novel environment in NK1R-/- mice
    Amy S Fisher
    Department of Anatomy and Development Biology, University College London, Gower Street, London WC1E 6BT, UK
    Eur J Neurosci 25:1195-204. 2007
    ..These changes could contribute to the difference in the behavioural phenotypes...
  40. ncbi Nerve growth factor and nerve growth factor receptors in respiratory syncytial virus-infected lungs
    Chengping Hu
    Department of Pediatrics, University of Miami School of Medicine, Miami, Florida 33136, USA
    Am J Physiol Lung Cell Mol Physiol 283:L494-502. 2002
    ..These data indicate that expression of NGF and its receptors in the lungs declines physiologically with age but is upregulated by RSV and is a major determinant of neurogenic inflammation...
  41. ncbi The role of the tachykinin NK1 receptor in airway changes in a mouse model of allergic asthma
    Katelijne O De Swert
    Department of Respiratory Diseases, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium
    J Allergy Clin Immunol 113:1093-9. 2004
    ..Human data suggest a role for these peptides in asthma, but the exact role of tachykinins and their receptors in allergic airway inflammation is still a matter of debate...
  42. ncbi The oral neurokinin-1 antagonist aprepitant for the prevention of chemotherapy-induced nausea and vomiting: a multinational, randomized, double-blind, placebo-controlled trial in patients receiving high-dose cisplatin--the Aprepitant Protocol 052 Study Gr
    Paul J Hesketh
    Caritas St Elizabeth s Medical Center, Brighton, MA 02135 2997, USA
    J Clin Oncol 21:4112-9. 2003
    ....
  43. ncbi The molecular dynamics of pain control
    S P Hunt
    Department of Anatomy and Developmental Biology, Medawar Building, University College London, Gower Street, London WC1E 6BT, UK
    Nat Rev Neurosci 2:83-91. 2001
    ..These new insights into pain processing will significantly alter our approach to pain control and the development of new analgesics...
  44. pmc Soma size distinguishes projection neurons from neurokinin 1 receptor-expressing interneurons in lamina I of the rat lumbar spinal dorsal horn
    K S Al Ghamdi
    Neuroscience and Molecular Pharmacology, Faculty of Biomedical and Life Sciences, West Medical Building, University Avenue, University of Glasgow, Glasgow G12 8QQ, UK
    Neuroscience 164:1794-804. 2009
    ..Since almost all of the NK1r-immunoreactive cells with soma size >200 microm(2) were retrogradely labelled, cells of this type can be identified as projection cells in anatomical studies...
  45. ncbi Distinct mechanism for antidepressant activity by blockade of central substance P receptors
    M S Kramer
    Merck Research Laboratories, West Point, PA 19456, USA
    Science 281:1640-5. 1998
    ..These findings suggest that substance P may play an important role in psychiatric disorders...
  46. ncbi Contribution of neuroimmune mechanisms to airway inflammation and remodeling during and after respiratory syncytial virus infection
    Giovanni Piedimonte
    Department of Pediatrics, Batchelor Children s Research Institute, University of Miami School of Medicine, 1580 NW Tenth Avenue, Miami, FL 33136, USA
    Pediatr Infect Dis J 22:S66-74; discussion S74-5. 2003
    ..On the basis of these observations, we postulate that changes of neurotrophin expression in the respiratory tract may represent an important link between early life viral infections and childhood asthma...
  47. pmc Large projection neurons in lamina I of the rat spinal cord that lack the neurokinin 1 receptor are densely innervated by VGLUT2-containing axons and possess GluR4-containing AMPA receptors
    Erika Polgár
    Faculty of Biomedical and Life Sciences, University of Glasgow, Glasgow, United Kingdom
    J Neurosci 28:13150-60. 2008
    ..Our results also provide the first evidence that postsynaptic GluR4-containing AMPA receptors are involved in spinal nociceptive transmission...
  48. ncbi The neurokinin 1 receptor: a potential new target for anti-platelet therapy?
    Sarah Jones
    School of Biological Sciences, University of Reading, Whiteknights, Reading, Berkshire RG6 6AJ, UK
    Curr Opin Pharmacol 8:114-9. 2008
    ..The pro-thrombotic effects of tachykinins on platelets are mediated through the neurokinin 1 receptor, which may therefore offer a novel therapeutic drug target in the prevention and the treatment of arterial thrombosis...
  49. pmc Detection of full-length and truncated neurokinin-1 receptor mRNA expression in human brain regions
    Jian Ping Lai
    Division of Allergy and Immunology, Joseph Stokes Jr Research Institute at The Children s Hospital of Philadelphia, Department of Pediatrics, University of Pennsylvania Medical School, Philadelphia, PA 19104, USA
    J Neurosci Methods 168:127-33. 2008
    ....
  50. ncbi Morphology and neurokinin 1 receptor expression of spinothalamic lamina I neurons in the rat spinal cord
    Xiao Hong Yu
    Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec H3G 1Y6, Canada
    J Comp Neurol 491:56-68. 2005
    ..As in the monkey, most pyramidal STT neurons did not express NK-1r. These results provide further evidence that distinct morphological types of neurons differ in phenotype but not in their projection pattern...
  51. ncbi Neurokinin 1 receptors trigger overlapping stimulation and inhibition of CaV2.3 (R-type) calcium channels
    Ulises Meza
    Department of Biology, Utah State University, 5305 Old Main Hill, Logan, UT 84322, USA
    Mol Pharmacol 71:284-93. 2007
    ..This new information concerning R-type calcium channels and NK1 receptors may help in understanding nociception, synaptic plasticity, and other physiological processes...
  52. ncbi The role of neurokinin 1 receptors in the maintenance of visceral hyperalgesia induced by repeated stress in rats
    Sylvie Bradesi
    Center for Neurovisceral Sciences and Women s Health, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA
    Gastroenterology 130:1729-42. 2006
    The neurokinin 1 receptors (NK(1)Rs) and substance P (SP) have been implicated in the stress and/or pain pathways involved in chronic pain conditions...
  53. ncbi The NK1 receptor is essential for the full expression of noxious inhibitory controls in the mouse
    H Bester
    Department of Anatomy and Developmental Biology, University College London, London WC1E 6BT, United Kingdom
    J Neurosci 21:1039-46. 2001
    ..The present study demonstrates that the NK1 receptor is essential for the full development of noxiously evoked descending inhibition...
  54. ncbi Clinical experience with substance P receptor (NK1) antagonists in depression
    K Ranga
    Department of Psychiatry, Duke University Medical Center, Durham, NC 27715, USA
    J Clin Psychiatry 63:25-9. 2002
    ..Future trials with SPAs will focus on the identification of appropriate patients and drug regimens and will also define the role of these agents in the treatment of depression...
  55. ncbi Cutting edge: hemokinin has substance P-like function and expression in inflammation
    Ahmed Metwali
    Department of Internal Medicine, Division of Gastroenterology Hepatology, University of Iowa, Iowa City, IA 52242, USA
    J Immunol 172:6528-32. 2004
    ..Two distinct but functionally overlapping tachykinins govern inflammation through NK-1R at sites of chronic inflammation...
  56. ncbi Efficient synthesis of novel NK1 receptor antagonists: selective 1,4-addition of grignard reagents to 6-chloronicotinic acid derivatives
    Fabienne Hoffmann-Emery
    F Hoffmann La Roche Ltd, Pharmaceuticals Division, Safety and Technical Sciences, Synthesis and Process Research, Grenzacherstrasse 124, CH 4070 Basel, Switzerland
    J Org Chem 71:2000-8. 2006
    ....
  57. ncbi Involvement of the second extracellular loop (E2) of the neurokinin-1 receptor in the binding of substance P. Photoaffinity labeling and modeling studies
    Olivier Lequin
    Unité Mixte de Recherches 7613 CNRS, Université Paul et Marie Curie, 4 place Jussieu, 75252 Paris Cedex 05, France
    J Biol Chem 277:22386-94. 2002
    ....
  58. ncbi Identification of single-nucleotide polymorphisms of the human neurokinin 1 receptor gene and pharmacological characterization of a Y192H variant
    G P Randolph
    CV CNS Biological Research and Discovery Technologies, Schering Plough Research Institute, Kenilworth, NJ 07033, USA
    Pharmacogenomics J 4:394-402. 2004
    ..In all cases the Y192H variant was found to display properties similar to those of the wild-type receptor...
  59. ncbi Neurokinin 1 receptor antagonism as a possible therapy for alcoholism
    David T George
    Laboratory of Clinical and Translational Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA
    Science 319:1536-9. 2008
    ..Thus, as assessed by these surrogate markers of efficacy, NK1R antagonism warrants further investigation as a treatment in alcoholism...
  60. ncbi The triple neurokinin-receptor antagonist CS-003 inhibits neurokinin A-induced bronchoconstriction in patients with asthma
    V Schelfhout
    Department of Respiratory Diseases, Ghent University Hospital, De Pintelaan 185, Ghent, Belgium
    Pulm Pharmacol Ther 19:413-8. 2006
    ..This did not occur under placebo treatment. A single dose of 200 mg CS-003 protected significantly against NKA-induced bronchoconstriction at 1 and 8h post-dose in mild asthmatics...
  61. pmc Genetic and pharmacological disruption of neurokinin 1 receptor function decreases anxiety-related behaviors and increases serotonergic function
    L Santarelli
    Center for Neurobiology and Behavior, Columbia University, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 98:1912-7. 2001
    ..Together these results indicate that the SP system powerfully modulates anxiety and suggest that this effect is at least in part mediated by changes in the 5-HT system...
  62. ncbi Neurokinin receptor 1-expressing spinal cord neurons in lamina I and III/IV of postnatal rats receive inputs from capsaicin sensitive fibers
    Charalampos Labrakakis
    Department of Physiology and Cellular Biophysics and the Center of Neurobiology and Behavior, Columbia University, New York, NY, USA
    Neurosci Lett 352:121-4. 2003
    ....
  63. ncbi Targeting neurokinin-1 receptor-expressing neurons with [Sar9,Met(O2)11 substance P-saporin
    R G Wiley
    Neurology Service 127, VAMC, Nashville, TN 37212 2637, USA
    Neurosci Lett 277:1-4. 1999
    ..SSP-saporin will be useful in larger species and for intraparenchymal injections...
  64. ncbi Neurokinin-1 receptor blockade and murine lung tumorigenesis
    Monica Lucattelli
    Department of Physiopathology, Experimental Medicine, and Public Health, University of Siena, Siena, Italy
    Am J Respir Crit Care Med 174:674-83. 2006
    ..However, the data supporting this sequence are largely circumstantial and the almost impossible task of identifying these lesions before resection rules out any longitudinal study in humans...
  65. ncbi Visualization and quantification of neurokinin-1 (NK1) receptors in the human brain
    Jarmo Hietala
    Neuropsychiatric Imaging, Turku PET Centre, Turku University Central Hospital, Finland
    Mol Imaging Biol 7:262-72. 2005
    ....
  66. ncbi Imaging substance P receptors (NK1) in the living human brain using positron emission tomography
    Richard Hargreaves
    Merck Research Laboratories, West Point, PA 19486, USA
    J Clin Psychiatry 63:18-24. 2002
    ..Future PET imaging studies will focus on quantification of NK1 receptor expression in depressed patients, both before and after successful treatment with antidepressants...
  67. ncbi Neurokinin-1 receptor antagonists CP-96,345 and L-733,060 protect mice from cytokine-mediated liver injury
    Renate Bang
    Institute of Experimental and Clinical Pharmacology and Toxicology, University of Erlangen Nuremberg, Erlangen, Germany
    J Pharmacol Exp Ther 305:31-9. 2003
    ..NK-1 receptor antagonists might be potent drugs for treatment of inflammatory liver disease, most likely by inhibiting SP effects...
  68. pmc Neurokinin-1 (NK-1) receptor is required in antigen-induced cystitis
    R Saban
    Department of Internal Medicine, Division of Gastroenterology and Hepatology, University of Texas Medical Branch, Galveston, Texas, 77555 0632, USA
    Am J Pathol 156:775-80. 2000
    ..This work presents the first evidence of participation of NK-1 receptors in cystitis and a mandatory participation of these receptors on the chain of events linking mast cell degranulation and inflammation...
  69. ncbi Substance P dependence of endosomal fusion during bladder inflammation
    T G Hammond
    Departments of Medicine and Surgery, Tulane University Medical Center, Tulane Environmental Astrobiology Center, Center for Bioenvironmental Research, and Veterans Affairs Medical Center, New Orleans, LA 70112
    Am J Physiol Renal Physiol 278:F440-51. 2000
    ..This suggests that NK1R can change the fusion properties of membranes in which it resides...
  70. pmc Neurokinin 1 receptor-expressing projection neurons in laminae III and IV of the rat spinal cord have synaptic AMPA receptors that contain GluR2, GluR3 and GluR4 subunits
    Andrew J Todd
    Neuroscience and Molecular Pharmacology, Faculty of Biomedical and Life Sciences, University of Glasgow, Glasgow, UK
    Eur J Neurosci 29:718-26. 2009
    ..These results show that synaptic AMPArs on the dendrites of the lamina III/IV NK1r projection neurons contain GluR2, GluR3 and GluR4, but not GluR1 subunits...
  71. ncbi Blockade of substance P (neurokinin 1) receptors enhances extracellular serotonin when combined with a selective serotonin reuptake inhibitor: an in vivo microdialysis study in mice
    Bruno P Guiard
    Laboratoire de Neuropharmacologie EA 3544 MJENR, Faculté de Pharmacie IFR75 Institut de Signalisation et d Innovation Thérapeutique, Universite Paris Sud, Chatenay Malabry, France
    J Neurochem 89:54-63. 2004
    ..p.) reversed this effect. The present findings suggest that NK1 receptor antagonists, when combined with a SSRI, augment 5-HT release by modulating substance P/5-HT interactions in the dorsal raphe nucleus...
  72. ncbi Neurokinin 1 receptors and neprilysin modulation of mouse bladder gene regulation
    Igor Dozmorov
    Oklahoma Medical Research Foundation, Microarray Research Facility, Oklahoma City, USA
    Physiol Genomics 12:239-50. 2003
    ....
  73. ncbi In vivo pain-inhibitory role of nociceptin/orphanin FQ in spinal cord
    Makoto Inoue
    Division of Molecular Pharmacology and Neuroscience, Nagasaki University Graduate School of Biomedical Sciences, 1 14 Bunkyo machi, Nagasaki 852 8521, Japan
    J Pharmacol Exp Ther 305:495-501. 2003
    ..All these findings suggest that the N/OFQ-ergic neuron may play an in vivo inhibitory role on the second-order neurons for primary polymodal substance P-ergic fibers in the spinal cord...
  74. ncbi Human positron emission tomography studies of brain neurokinin 1 receptor occupancy by aprepitant
    Mats Bergstrom
    Uppsala Positron Emission Tomography Centre, Uppsala, Sweden
    Biol Psychiatry 55:1007-12. 2004
    ....
  75. ncbi The substance P receptor is necessary for a normal granulomatous response in murine schistosomiasis mansoni
    A M Blum
    Division of Gastroenterology Hepatology, Department of Internal Medicine, University of Iowa, Iowa City, IA 52242, USA
    J Immunol 162:6080-5. 1999
    ..These results provide further evidence that in murine schistosomiasis SPr is displayed commonly on granuloma inflammatory cells and is important for granuloma development and expression of IFN-gamma circuitry in this natural infection...
  76. ncbi Expression of tachykinin NK1 receptor mRNA in dorsal root ganglia of the mouse
    T Andoh
    Department of Applied Pharmacology, Toyama Medical and Pharmaceutical University, Japan
    Brain Res Mol Brain Res 35:329-32. 1996
    ..The present results suggest that NK1 receptor mRNA is expressed in the mouse DRG, although the level is relatively low...
  77. pmc Collateral projections of neurons in laminae I, III, and IV of rat spinal cord to thalamus, periaqueductal gray matter, and lateral parabrachial area
    Khulood M Al-Khater
    Neuroscience and Molecular Pharmacology, Faculty of Biomedical and Life Sciences, University of Glasgow, Glasgow, UK
    J Comp Neurol 515:629-46. 2009
    ..These results confirm that neurons in these laminae have extensive collateral projections and suggest that different neuronal subpopulations in lamina I have characteristic patterns of supraspinal projection...
  78. ncbi Morphological characterization of spinal cord dorsal horn lamina I neurons projecting to the parabrachial nucleus in the rat
    L Almarestani
    Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec H3G 1Y6, Canada
    J Comp Neurol 504:287-97. 2007
    ..In addition, our study provides further evidence that these distinct morphological types of neurons differ in their phenotypic properties, but not in their projection patterns...
  79. pmc [3H]GR205171 displays similar NK1 receptor binding profile in gerbil and human brain
    Cristiana Griffante
    Psychiatry Centre of Excellence for Drug Discovery, GlaxoSmithKline Group, Medicines Research Centre, 37135 Verona, Italy
    Br J Pharmacol 148:39-45. 2006
    ....
  80. ncbi The murine neurokinin NK1 receptor gene contributes to the adult hypoxic facilitation of ventilation
    Krzysztof Ptak
    Physiologie Neurovégétative, UMR 6153 CNRS INRA, Faculté des Sciences de St Jérôme, 13397 Marseille Cedex 20, France
    Eur J Neurosci 16:2245-52. 2002
    ..However, NK1 receptors are not obligatory for the prenatal development of the respiratory network, for the production of the rhythm, or for the regulation of breathing by short-lasting hypoxia in neonates...
  81. ncbi Functional expression of neurokinin 1 receptors on mast cells induced by IL-4 and stem cell factor
    Hanneke P M van der Kleij
    Department of Pharmacology and Pathophysiology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands
    J Immunol 171:2074-9. 2003
    ..In conclusion, BMMC were shown to express NK(1) receptors upon IL-4/SCF coculture. This expression of NK(1) receptors has been demonstrated to be of functional relevance and leads to an increase in the sensitivity of BMMC to substance P...
  82. ncbi Brain uptake and receptor binding of two [11C]labelled selective high affinity NK1-antagonists, GR203040 and GR205171--PET studies in rhesus monkey
    M Bergstrom
    Uppsala University PET Centre, University Hospital, Sweden
    Neuropharmacology 39:664-70. 2000
    ..The pre-treatment dose of cold GR205171 needed for 50% inhibition of binding was less than 0.04 mg/kg. The studies indicated that [11C]GR205171 could be used for the in vivo characterisation of NK1-receptor binding...
  83. ncbi Neurogenic inflammation in acute pancreatitis
    Akhil Hegde
    JOP 6:417-21. 2005
    ..This editorial focuses on the role of substance P and its receptors in the development of acute pancreatitis...
  84. ncbi Noradrenaline is necessary for the hedonic properties of addictive drugs
    Luc Jasmin
    Department of Neurological Surgery and W M Keck Foundation Center for Integrative Neuroscience, University of California San Francisco, San Francisco, CA 94143, USA
    Vascul Pharmacol 45:243-50. 2006
    ..The reversibility of this phenomenon, by restoring NA, indicates that even when this behavioral deficit is genetically determined it can be reversed...
  85. ncbi A population of large lamina I projection neurons with selective inhibitory input in rat spinal cord
    Z Puskar
    Spinal Cord Group, IBLS, University of Glasgow, G12 8QQ, Glasgow, UK
    Neuroscience 102:167-76. 2001
    ..These cells are under powerful inhibitory control, and the study provides further evidence that inhibitory circuits in the dorsal horn are organized in a specific manner...
  86. ncbi The neuropeptide substance P is a critical mediator of burn-induced acute lung injury
    Selena Wei Shan Sio
    Department of Pharmacology, National University of Singapore, Singapore
    J Immunol 180:8333-41. 2008
    ..The present findings show for the first time the role of SP in contributing to exaggerated pulmonary inflammatory damage after burn injury via activation of NK1R signaling...
  87. ncbi P-Glycoprotein efflux reduces the brain concentration of the substance P (NK1 receptor) antagonists SR140333 and GR205171: a comparative study using mdr1a-/- and mdr1a+/+ mice
    N M J Rupniak
    Department of Pharmacology, Merck Sharp and Dohme Research Laboratories, Neuroscience Research Centre, Harlow, Essex, UK
    Behav Pharmacol 14:457-63. 2003
    ..These findings suggest that P-gp deficient mice may have useful applications in behavioural pharmacology studies, especially when highly brain-penetrant compounds are not yet available...
  88. doi Substance P receptor-expressing dorsal horn neurons: lessons from the targeted cytotoxin, substance P-saporin
    Ronald G Wiley
    Laboratory of Experimental Neurology, Neurology Service, VA TVHS, 1310 24th Avenue, South Nashville, TN 37212 2637, USA
    Pain 136:7-10. 2008
  89. ncbi Cyclopentane-based human NK1 antagonists. Part 2: development of potent, orally active, water-soluble derivatives
    Laura C Meurer
    Department of Medicinal Chemistry, Merck Research Laboratories, Rahway, NJ 07065, USA
    Bioorg Med Chem Lett 16:4504-11. 2006
    ..Sub-nanomolar hNK1 binding was achieved and oral activity comparable to Aprepitant in two in vivo models will be described...
  90. ncbi De novo expression of the neurokinin 1 receptor in spinal lamina I pyramidal neurons in polyarthritis
    L Almarestani
    Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada
    J Comp Neurol 514:284-95. 2009
    ....
  91. ncbi Lack of efficacy of the substance p (neurokinin1 receptor) antagonist aprepitant in the treatment of major depressive disorder
    Martin Keller
    Department of Psychiatry and Human Behavior, Brown University, Providence, Rhode Island, USA
    Biol Psychiatry 59:216-23. 2006
    ..An early clinical trial suggested that the substance P (neurokinin(1) receptor) antagonist, aprepitant, might provide a unique mechanism of antidepressant activity. Phase III trials were conducted to confirm these findings...
  92. ncbi Substance P acts via the neurokinin receptor 1 to elicit bronchoconstriction, oxidative stress, and upregulated ICAM-1 expression after oil smoke exposure
    Ping Chia Li
    Dept of Occupational Therapy, I Shou Univ, No 8 E Da Road, Jiau Shu Tsuen, Yan Chau Shiang, Kaohsiung County 824, Tainan City, Republic of China Taiwan
    Am J Physiol Lung Cell Mol Physiol 294:L912-20. 2008
    ..These findings suggest that SP acts via the NK-1 receptor to provoke neurogenic inflammation, oxidative stress, and ICAM-1 expression after OSE in rats...
  93. ncbi The role of neural inflammation in asthma and chronic obstructive pulmonary disease
    Guy F Joos
    Department of Respiratory Diseases, Ghent University Hospital, De Pintelaan 185, B 9000 Ghent, Belgium
    Ann N Y Acad Sci 992:218-30. 2003
    ..It is suggested that dual NK(1)/NK(2) and triple NK(1)/NK(2)/NK(3) tachykinin receptor antagonists have potential in the treatment of obstructive airway diseases...
  94. ncbi Inflammation-induced up-regulation of neurokinin 1 receptors in rat glabrous skin
    Susan M Carlton
    Department of Anatomy and Neurosciences, Marine Biomedical Institute, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555 1069, USA
    Neurosci Lett 326:29-32. 2002
    ....
  95. ncbi Elucidating the antidepressant actions of substance P (NK1 receptor) antagonists
    Nadia M J Rupniak
    Merck Sharp and Dohme Research Laboratories, Neuroscience Research Centre, Harlow, Essex, UK
    Curr Opin Investig Drugs 3:257-61. 2002
    ..Additional studies are needed to explore these hypothesesfurther...
  96. pmc Metalloelastase in lungs and alveolar macrophages is modulated by extracellular substance P in mice
    J Xu
    Pathophysiology Program, Lovelace Respiratory Research Institute, Albuquerque, New Mexico 87108, USA
    Am J Physiol Lung Cell Mol Physiol 295:L162-70. 2008
    ..These findings suggest that SP has a modulatory effect on pulmonary MMP-12 by acting on NK1R to trigger MMP-12 syntheses in the AMs...
  97. ncbi Selective innervation of lamina I projection neurones that possess the neurokinin 1 receptor by serotonin-containing axons in the rat spinal cord
    E Polgar
    Spinal Cord Group, IBLS, University of Glasgow, UK
    Neuroscience 109:799-809. 2002
    ..innervation of lamina I projection neurones in the rat spinal cord is related to expression of neurokinin 1 receptors, but not to morphology, and that (at least on heavily innervated neurones) most serotonin-containing ..
  98. ncbi Anti-nociceptive effects of selectively destroying substance P receptor-expressing dorsal horn neurons using [Sar9,Met(O2)11]-substance P-saporin: behavioral and anatomical analyses
    R G Wiley
    Laboratory of Experimental Neurology, VA TVHS, Nashville, TN 37212 2637, USA
    Neuroscience 146:1333-45. 2007
    ..SSP-sap is an attractive agent for possible treatment of chronic pain...
  99. ncbi Destruction of neurokinin-1 receptor expressing cells in vitro and in vivo using substance P-saporin in rats
    R G Wiley
    Neurology Service, VAMC, Nashville, TN 37212 2637, USA
    Neurosci Lett 230:97-100. 1997
    ..Injection of SP-SAP into the striatum selectively destroyed NK-1 receptor expressing interneurons. These results show that SP-SAP will be useful for studying the function of NK-1 receptor expressing neurons...
  100. ncbi Tachykinins: role in detrusor overactivity?
    Karl Erik Andersson
    Eur Urol 49:423-5. 2006
  101. ncbi Effects of analgesic or antidepressant drugs on pain- or stress-evoked hippocampal and spinal neurokinin-1 receptor and brain-derived neurotrophic factor gene expression in the rat
    Vanja Duric
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, 3901 Rainbow Blvd, MSN 1018, Kansas City, KS 66160, USA
    J Pharmacol Exp Ther 319:1235-43. 2006
    ....

Research Grants63

  1. Role of the neurogenic inflammatory pathway in the genital tract immune response
    Roger G Rank; Fiscal Year: 2010
    ....
  2. Surgical Wound Repair: Role of A Neuroendothelial Axis
    NICOLE SIMONE GIBRAN; Fiscal Year: 2010
    ..We will employ siRNA to deplete neuropeptide receptors on endothelial cells to further define neural modulation of endothelial cell inflammatory responses, migration and proliferation. ..
  3. Presynaptic NMDAR Regulation of Substance P Release in the RVM After Injury
    UCHECHUKWU PATRICK MADUKA; Fiscal Year: 2013
    ....
  4. REGULATION OF CELLULAR RESPONSES TO NEUROPEPTIDES
    Nigel W Bunnett; Fiscal Year: 2010
    ..For type specifications, see Specific Instructions onpage 10.) RESEARCH GRANT TABLE OF CONTENTS PAGE NUMBERS Face page 1 Description, ..
  5. GENETIC ORGANIZATION OF RESPIRATORY CIRCUITS IN MOUSE BRAINSTEM
    Paul Gray; Fiscal Year: 2013
    ..Understanding the genetic organization of the brainstem neurons that generate breathing is essential for the diagnosis and treatment of breathing disorders. ..
  6. Effect of Prenatal Nicotinic Exposure on Control of Hypoxic Ventilatory Response
    Fadi Xu; Fiscal Year: 2013
    ....
  7. Use of Substance P antagonists to regulate the skin immune function
    Adriana T Larregina; Fiscal Year: 2013
    ..Specific Aim 3: To analyze, the possibility of using local administration of specific NK1R antagonists to suppress CHS by down-regulating the T cell-stimulatory function of sDCs and their precursors. ..
  8. NMDA Receptors in Primary Afferents
    James A McRoberts; Fiscal Year: 2013
    ..Using rodent models, we will test the predictions that neuropathic and visceral pain increase NMDA-induced SP release, and decrease after selective knockdown of NMDARs in primary afferents. ..
  9. Ponce School of Medicine - Moffitt Cancer Center Partnership
    WARREN JACKSON PLEDGER; Fiscal Year: 2011
    ..Appleyard in the Minority-Serving Institute (MSI) to successfully compete for a R01 grant from the National Cancer Institute (NCI) and will increase the quality of graduate education at the MSI. ..
  10. Sigma 1 receptor as a master regulator of pronociceptive protein trafficking in t
    Jay Yang; Fiscal Year: 2013
    ....
  11. Anti-HIV Neuroimmunomodulatory Therapy with Neurokinin-1 (NK1-R) Antagonists
    STEVEN DANIEL DOUGLAS; Fiscal Year: 2013
    ..This NK1RA has activity as an antiviral HIV agent that improves innate immunity (Natural Killer cells) and has positive neurobehavioral effects. NK1RA are a potential novel therapy for neuroAIDS...
  12. Neural Mechanisms of Itch
    Earl E Carstens; Fiscal Year: 2013
    ..These hypotheses will be addressed using two murine models of chronic itch, the NC "itchy" mouse strain, and experimental dry skin. ..
  13. Interdependence among neuromodulators of ventilatory control
    Hubert V Forster; Fiscal Year: 2013
    ....
  14. Functional dissection of the Tac2-Nk3R pathway to prevent fear consolidation
    Kerry J Ressler; Fiscal Year: 2013
    ..These findings will energize and support a new research program aimed at translating the modulation of the Tac2/Nk3 pathway to provide novel approaches to intervention following fear and trauma exposure for the prevention of the PTSD. ..
  15. Lethal H5N1 Virus Infection and Respiratory Disorders
    Fadi Xu; Fiscal Year: 2013
    ....
  16. New Neural Targets for Opioid Use Disorders: Human Studies
    Sharon L Walsh; Fiscal Year: 2010
    ..Thus, these studies, conducted in healthy humans, will provide fundamental information regarding the potential for this system as a target for development of new treatment agents for opioid use disorders. ..
  17. Truncated NK1R in GBM: Pharmacology and Relationship with Patient Survival
    Madan M Kwatra; Fiscal Year: 2013
    ..The unique combination of the PI's expertise in NK1R biology and the resources available at Duke's Preston Robert Tisch Brain Tumor Center ensures successful completion of these studies. ..
  18. Role of Substance P in Intestinal Inflammation
    Charalabos Pothoulakis; Fiscal Year: 2013
    ..Part of this project will also examine whether SP-mediated responses in human preadipocytes influence pathways that link colitis with the metabolic syndrome and insulin resistance. ..
  19. Substance P exacerbation of CNS inflammation
    MARIO TOMAS PHILIPP; Fiscal Year: 2013
    ....
  20. Development of Topical Neuroinflammatory Inhibitors
    MANDIP SACHDEVA; Fiscal Year: 2005
    ..The results of these studies are intended to provide the basic information required for the development of novel skin disorders. ..
  21. CD163 in HIV Immunopathogenesis
    STEVEN DANIEL DOUGLAS; Fiscal Year: 2013
    ..This R21 focuses on the mechanisms of HIV infection in macrophages and has direct implications for development of novel HIV therapies. ..
  22. Neuronal Plasticity Related to TMD and Fibromyalgia
    Dean Dessem; Fiscal Year: 2006
    ..Because a gender difference is reported for TMD and FM, both hypotheses will be tested in males, estrous females and diestrous females. ..
  23. NEUROGENIC MECHANISMS OF INTESTINAL INFLAMMATION
    Eileen Grady; Fiscal Year: 2006
    ..Together, the results of these experiments will provide new insights into peptide signaling, generate novel information about mechanisms of intestinal inflammation, and suggest new strategies for therapy. ..
  24. Nanoparticle mediated in vivo cell-type specific drug delivery for pain relief
    Zhigang David Luo; Fiscal Year: 2013
    ..Promising data derived from this project will be used for the application of a larger scale NIH R01 project related to application of siRNA/nanoparticles in targeted gene silencing and pain relief. ..
  25. NOCICEPTIVE SENSORY REGULATION OF NEUROKININ RECEPTORS
    KENNETH MC CARSON; Fiscal Year: 2004
    ..abstract_text> ..
  26. Substance P & the Regulation of Intestinal Inflammation
    Joel Weinstock; Fiscal Year: 2009
    ..Strategies aimed at modulating NK-1 R function in the gut could prove therapeutically beneficial for IBD. ..
  27. DORSAL SPINAL CORD STIMULATION--VASODILATOR MECHANISMS
    Robert Foreman; Fiscal Year: 2001
    ....
  28. NEUROTRANSMITTER FUNCTION IN SPINAL SENSORY TRANSMISSION
    Thomas Jessell; Fiscal Year: 1993
    ..the mechanisms of signalling evoked by substance P in these two classes of neurons will be examined in detail...
  29. NORADRENERGIC DYSFUNCTION--A MODEL OF FIBROMYALGIA PAIN
    Luc Jasmin; Fiscal Year: 2001
    ..abstract_text> ..
  30. Magnesium Deficiency: Effect on Bone and Mineral
    Robert Rude; Fiscal Year: 2004
    ..These studies should substantiate our hypothesis that Mg depletion contributes to osteoporosis and provide mechanistic explanations. ..
  31. MECHANISMS OF SYNAPTIC MODULATION IN SYMPATHETIC NEURONS
    Mark Simmons; Fiscal Year: 2000
    ..internalization of the substance P receptor in single neurons? 2) What are the requirements for resensitization of the substance P receptor? 3) What is the mechanism for desensitization of responses to gonadotrophin-releasing hormone? ..
  32. EFFECT OF DENERVATION ON THE FUNCTION OF THE AIRWAYS
    J PEREZ FONTAN; Fiscal Year: 2004
    ..abstract_text> ..
  33. The Roles of Heme Oxygenase in Pain
    David Clark; Fiscal Year: 2005
    ....
  34. MECHANISMS OF G PROTEIN COUPLED RECEPTOR REGULATION
    LAWRENCE BARAK; Fiscal Year: 2002
    ..Insight gained from them should provide a foundation for the development of new treatment regiments that target diseases such as hypertension, heart failure, and chronic pain syndromes. ..
  35. NEUROCHEMISTRY OF NOCICEPTION
    Patrick Mantyh; Fiscal Year: 2002
    ....
  36. MOLECULAR PATHOGENESIS OF RADIATION ENTEROPATHY
    Martin Hauer Jensen; Fiscal Year: 2005
    ..This project may facilitate development of specific strategies to minimize intestinal radiation toxicity, thereby making radiation therapy safer and more effective. ..
  37. THERMAL HYPERALGESIA IN AGED
    WILLIAM CRUCE; Fiscal Year: 1999
    ..The long term goals of the investigators are to study neuropathic pain in aged animals so that we have a better basis on which to design treatments for this condition. ..
  38. CENTRAL INTERACTION OF BARORECEPTOR & SOMATIC AFFERENTS
    Jeffrey Potts; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  39. MACROPHAGE ACTIVATION & SUBSTANCE P RECEPTOR EXPRESSION
    KENNETH BOST; Fiscal Year: 2006
    ..Taken together, these studies will demonstrate that substance P is an integral part of the host immune response against pathogens. ..
  40. Targeting Neurons Involved in Chronic Pain Transmission
    DOUGLAS LAPPI; Fiscal Year: 2001
    ..Additionally, an expression system that can diminish rather than destroy a cell's function would have great possibility in the treatment of disease. ..
  41. Lateral Pontine Neurons in the Control of Breathing
    DONALD MC CRIMMON; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
  42. GASTROINTESTINAL MOTOR EFFECTS OF IONIZING RADIATION
    Mary Otterson; Fiscal Year: 2000
    ..The primary objectives of this research proposal are 1) to explore the role of central and peripheral neurokinin 1 receptors in the contractile changes produced by irradiation, 2) to understand the mechanisms of the coordination ..
  43. STIMULUS-SPECIFIC SI CORTICOCORTICAL INTERACTIONS
    Barry Whitsel; Fiscal Year: 2007
    ..abstract_text> ..
  44. Vaccine hurdle to anthrax and the emerging immune system
    Pranela Rameshwar; Fiscal Year: 2006
    ..This study will also form the basis to develop in vivo model with human hematopoietic system to study anthrax infection and also to improve responses to anthrax vaccines. ..
  45. BREAST CANCER/BONE MARROW STROMAL INTERACTIONS
    Pranela Rameshwar; Fiscal Year: 2003
    ..Since BC metastasis involves two major cell subsets, mesenchymal (stroma) and epithelial (BC), aim 4 will determine if regulation of PPT-I, NK-1 and NK-2 is tissue specific by studying their promoters in these cell subsets. ..
  46. CSF AND THE CENTRAL CHEMICAL CONTROL OF BREATHING
    Eugene Nattie; Fiscal Year: 2008
    ..abstract_text> ..
  47. PHILADELPHIA PEDIATRIC AIDS CLINICAL TRIALS UNIT
    Steven Douglas; Fiscal Year: 2006
    ..abstract_text> ..
  48. MECHANISMS OF CANNABINOID'S ANTIEMETIC ACTIONS
    NISSAR DARMANI; Fiscal Year: 2007
    ..The results will have important implications for the therapeutic utility of these "agonist antiemetics". [unreadable] [unreadable]..
  49. Spinal Opioid Release in Nociception
    Juan Carlos Marvizon; Fiscal Year: 2008
    ..Internalization of neurokinin 1 receptors and mu-opioid receptors will be used to measure neurokinin and opioid release, respectively...
  50. Neurokinin-1R (SP Receptor) Antagonists for HIV Therapy
    Steven Douglas; Fiscal Year: 2008
    ....
  51. Interaction of Human Immune Cells Alcohol & HIV
    Steven Douglas; Fiscal Year: 2005
    ..These studies may provide new mechanistic insights related to the role of alcohol in the pathogenesis of HIV disease and AIDS and toward design of new therapeutic approaches. ..
  52. MECHANISMS OF CANNABINOIDS ANTIEMETIC ACTIONS
    NISSAR DARMANI; Fiscal Year: 2001
    ..The results will define an important role for the cannabinoid receptors in the vomiting circuits and may implicate an antiemetic role for the endogenous cannabinoids. ..
  53. ORGANIZATION OF CENTRAL SYMPATHETIC PATHWAYS
    PATRICE GUYENET; Fiscal Year: 2008
    ..The research will contribute to the basic physiological knowledge needed to understand how syrr pathetic tone is regulated in health and in diseases such as arrhythmias, hypertension and dysautonomias. ..
  54. REGULATION OF GUT SUBSTANCE P RECEPTORS
    STEVEN VIGNA; Fiscal Year: 2006
    ..These studies will lead to insight into the normal mechanisms of SP NK-1R regulation and will suggest possible mechanisms of abnormal NK-1R regulation in intestinal inflammatory diseases. ..
  55. Injury Induced Facilitated Neurogenic Inflammation
    Wade Kingery; Fiscal Year: 2006
    ..abstract_text> ..
  56. NEURAL REGULATION OF BONE REMODELING
    Wade Kingery; Fiscal Year: 2008
    ..These investigations will help to identify the sensory transmitters that modulate bone remodeling and characterize their roles in osteoporotic processes. ..
  57. LPS-PEPTIDE INTERACTION IN BLADDER INFLAMMATION
    Ricardo Saban; Fiscal Year: 2007
    ..Information generated by this study should elucidate whether bladder inflammatory responses, regardless of etiology, occur via a common mechanism or whether the endpoints are specific for each stimulus. ..
  58. Neuropeptides in the pathogenesis of neurocysticercosis
    Prema Robinson; Fiscal Year: 2007
    ..abstract_text> ..
  59. Particulate Matter Exposure: Cardiovascular Mechanisms
    Chao Yin Chen; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  60. CENTRAL NEURONAL MECHANISMS--DECOMPENSATED HEMORRHAGE
    PATRICE GUYENET; Fiscal Year: 2003
    ..Understanding the neurophysiological mechanisms triggered by hypotensive hemorrhage should lead to improved ability to manage this all too frequent clinical problem. ..
  61. Urothelial Cell Physiology in Normal and Disease States
    Ricardo Saban; Fiscal Year: 2005
    ..Scott-Hultgren (Washington U) will discuss the molecular basis of persistent bladder infections. The bladder cancer discussion will be chaired by Drs. Robert Hurst (Oklahoma U) and Jenny Southgate (U. York). ..
  62. HIPPOCAMPAL NETWORK STRUCTURE AND FUNCTION IN EPILEPSY
    ROBERT SLOVITER; Fiscal Year: 2006
    ..abstract_text> ..