Genomes and Genes
neurokinin 1 receptors
Summary: A class of cell surface receptors for tachykinins with a preference for substance P. Neurokinin-1 (NK-1) receptors have been cloned and are members of the G protein coupled receptor superfamily. They are found on many cell types including central and peripheral neurons, smooth muscle cells, acinar cells, endothelial cells, fibroblasts, and immune cells.
Publications284 found, 100 shown here
- A key role of neurokinin 1 receptors in acute pancreatitis and associated lung injuryHon Yen Lau
Department of Pharmacology, National University of Singapore, Singapore
Biochem Biophys Res Commun 327:509-15. 2005..Pulmonary microvascular permeability was also reduced as a result of CP-96345 treatment. These results point to a key role of NK1 receptors in acute pancreatitis and associated lung injury...
- Disinhibition opens the gate to pathological pain signaling in superficial neurokinin 1 receptor-expressing neurons in rat spinal cordCarole Torsney
Department of Physiology and Cellular Biophysics, Center for Neurobiology and Behavior, Columbia University, New York, New York 10032, USA
J Neurosci 26:1833-43. 2006..These disinhibition-induced changes, in particular the novel polysynaptic low-threshold input onto lamina I NK1R+ neurons, may be an underlying component of the hypersensitivity present in chronic pain states...
- Persistent pain produces stress-like alterations in hippocampal neurogenesis and gene expressionVanja Duric
Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, KS 66160, USA
J Pain 7:544-55. 2006....
- Substance P: a pioneer amongst neuropeptidesT Hokfelt
Department of Neuroscience, and Department of Clinical Physiology, Karolinska Institutet, S 17177 Stockholm, Sweden
J Intern Med 249:27-40. 2001....
- Projection neurons in lamina I of rat spinal cord with the neurokinin 1 receptor are selectively innervated by substance p-containing afferents and respond to noxious stimulationAndrew J Todd
Spinal Cord Group, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ, United Kingdom
J Neurosci 22:4103-13. 2002..We conclude that presence or absence of the NK1 receptor is a better indicator of function than morphology for lamina I projection neurons in the rat...
- Spinal neurons that possess the substance P receptor are required for the development of central sensitizationSergey G Khasabov
Department of Preventive Sciences, University of Minnesota, Minneapolis, Minnesota 55455, USA
J Neurosci 22:9086-98. 2002..It appears that this relatively small population of neurons can regulate the physiological properties of other nociceptive neurons and drive central sensitization...
- The role of substance P in stress and anxiety responsesK Ebner
Department of Pharmacology and Toxicology, Institute of Pharmacy, Center for Molecular Biosciences Innsbruck, University of Innsbruck, Innsbruck, Austria
Amino Acids 31:251-72. 2006..Preclinical and clinical studies have found evidence in favour of such an assumption. The status of this research is reviewed here...
- Aprepitant: a review of its use in the prevention of chemotherapy-induced nausea and vomitingToni M Dando
Adis International Limited, 41 Centorian Drive, PB 65901, Mairangi Bay, Auckland, New Zealand
Drugs 64:777-94. 2004..Despite marked advances in the prevention of CINV, standard therapy does not protect all patients. The addition of aprepitant to standard therapy provides an advance in the prevention of both acute and delayed CINV in adults with cancer...
- Tachykinins regulate the function of plateletsGwenda J Graham
School of Animal and Microbial Sciences, The University of Reading, Whiteknights, Reading, Berkshire, RG6 6AJ, UK
Blood 104:1058-65. 2004..Together our data implicate tachykinins, specifically SP and EKA/B, in the regulation of platelet function...
- Human monocytes and macrophages express substance P and neurokinin-1 receptorW Z Ho
Division of Immunologic and Infectious Diseases, Joseph Stokes Jr Research Institute at The Children s Hospital of Philadelphia, PA 19104, USA
J Immunol 159:5654-60. 1997..The demonstration that human monocytes and macrophages express substance P and its receptor support the notion that substance P is biologically involved in regulating the functions of these cells in an autocrine fashion...
- Substance P stimulates cyclooxygenase-2 and prostaglandin E2 expression through JAK-STAT activation in human colonic epithelial cellsHon Wai Koon
Gastrointestinal Neuropeptide Center, Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
J Immunol 176:5050-9. 2006..Our results demonstrate that SP stimulates COX-2 expression and PGE2 production in human colonocytes via activation of the JAK2-STAT3/5 pathway...
- Postsynaptic dorsal column neurons express NK1 receptors following colon inflammationJ Palecek
Department of Anatomy and Neuroscience, Marine Biomedical Institute, The University of Texas Medical Branch, Galveston, TX 77555 1069, USA
Neuroscience 116:565-72. 2003..The presence of immunoreactivity for neurokinin 1 receptors on these postsynaptic dorsal column neurons was examined under control conditions and after colon ..
- Phosphorylation of ERK in neurokinin 1 receptor-expressing neurons in laminae III and IV of the rat spinal dorsal horn following noxious stimulationErika Polgár
Spinal Cord Group, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK
Mol Pain 3:4. 2007..The stimuli were mechanical (repeated pinching), thermal (immersion in water at 52 degrees C) or chemical (injection of 2% formaldehyde)...
- Neurokinin 1 receptors regulate morphine-induced endocytosis and desensitization of mu-opioid receptors in CNS neuronsY Joy Yu
Program in Neuroscience, University of California at San Francisco, San Francisco, California 94158 2140, USA
J Neurosci 29:222-33. 2009..MORs are coexpressed with neurokinin 1 receptors (NK1Rs) in several regions of the CNS that control opioid dependence and reward...
- Molecular evidence that granuloma T lymphocytes in murine schistosomiasis mansoni express an authentic substance P (NK-1) receptorG A Cook
Department of Animal Health and Biomedical Sciences, University of Wisconsin, Madison 53706
J Immunol 152:1830-5. 1994..CD4+ granuloma T lymphocytes, purified by FACS, express NK-1 receptor mRNA. Normal liver devoid of granulomas exhibited none of the three tachykinin receptor subclasses...
- Altered nociception, analgesia and aggression in mice lacking the receptor for substance PC De Felipe
Instituto de Neurociencias, Universidad Miguel Hernandez, Alicante, Spain
Nature 392:394-7. 1998....
- Synaptic plasticity in spinal lamina I projection neurons that mediate hyperalgesiaHiroshi Ikeda
Institute of Physiology and Pathophysiology, Heidelberg University, D 69120 Heidelberg, Germany
Science 299:1237-40. 2003..Thereby, memory traces of painful events are retained...
- Neurokinin-1 receptor enhances TRPV1 activity in primary sensory neurons via PKCepsilon: a novel pathway for heat hyperalgesiaHua Zhang
Institute of Neurobiology, Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai 200032, China
J Neurosci 27:12067-77. 2007..These results reveal a novel mechanism of NK-1 in primary sensory neurons via a possible autocrine and paracrine action of SP. Activation of NK-1 in these neurons induces heat hyperalgesia via PKCepsilon-mediated potentiation of TRPV1...
- Involvement of spinal tachykinin NK1 and NK2 receptors in detrusor hyperreflexia during chemical cystitis in anaesthetized ratsA Lecci
Pharmacology Research Department Menarini Pharmaceuticals, Florence, Italy
Eur J Pharmacol 259:129-35. 1994..abstract truncated at 250 words)..
- Identification, localization and receptor characterization of novel mammalian substance P-like peptidesMarc M Kurtz
Department of Immunology Rheumatology, Merck Research Laboratories, Rahway, NJ 07065, USA
Gene 296:205-12. 2002..The results indicate that PPT-C encodes another high affinity ligand of the NK1 receptor which may play an important role in mediating some of the physiological roles previously assigned to the NK1 receptor...
- Prevention of cisplatin-induced acute and delayed emesis by the selective neurokinin-1 antagonists, L-758,298 and MK-869Simon Van Belle
Oncologisch Centrum, Universitair Ziekenhuis, Gent, Belgium
Cancer 94:3032-41. 2002....
- 5-hydroxytryptamine (5-HT)1A autoreceptor adaptive changes in substance P (neurokinin 1) receptor knock-out mice mimic antidepressant-induced desensitizationN Froger
Institut National de la Sante et de la Recherche Medicale U288, NeuroPsychoPharmacologie Moléculaire, Cellulaire et Fonctionnelle, Faculté de Médecine Pitié Salpêtrière, 75013 Paris, France
J Neurosci 21:8188-97. 2001..Double immunocytochemical labeling experiments suggest that such a heteroregulation of 5-HT(1A) autoreceptors in NK1-/- mutants does not reflect the existence of direct NK1-5-HT(1A) receptor interactions in normal mice...
- A quantitative and morphological study of projection neurons in lamina I of the rat lumbar spinal cordR C Spike
Spinal Cord Group, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ, United Kingdom
Eur J Neurosci 18:2433-48. 2003..These results suggest that many lamina I cells project to more than one site in the brain and that those projecting to PAG may represent a distinct subclass of lamina I projection neuron...
- Contribution of neurokinin 1 receptors in the cutaneous orofacial inflammatory painPhilippe Luccarini
INSERM E 0216, Neurobiologie de la douleur trigeminale, Faculte de Chirurgie Dentaire, 11 Boulevard Charles de Gaulle, 63000, Clermont Ferrand, France
Naunyn Schmiedebergs Arch Pharmacol 368:320-3. 2003This study investigated the role of neurokinin 1 receptors (NK1R) in inflammatory cutaneous orofacial pain...
- PET evaluation of the uptake of N-[11C]methyl CP-643,051, an NK1 receptor antagonist, in the living porcine brainD Bender
PET Centre, Aarhus University Hospitals, Aarhus, Denmark
Nucl Med Biol 31:699-704. 2004..We conclude that of N-[11C]methyl CP-643,051 may serve as a lead structure for the development of PET NK-1 ligands of higher specific binding in vivo...
- Primary afferent tachykinins are required to experience moderate to intense painY Q Cao
Department of Anatomy, W M Keck Foundation Center for Integrative Neuroscience, University of California San Francisco, 94143 0452, USA
Nature 392:390-4. 1998..We conclude that the release of tachykinins from primary afferent pain-sensing receptors (nociceptors) is required to produce moderate to intense pain...
- Hippocampal neurokinin-1 receptor and brain-derived neurotrophic factor gene expression is decreased in rat models of pain and stressV Duric
Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, 3901 Rainbow Boulevard, Mail Stop 1018, Kansas City, KS 66160, USA
Neuroscience 133:999-1006. 2005..These data may provide useful markers of hippocampal activation during chronic pain, and suggest similarities in the mechanisms underlying chronic pain and depression...
- Time-course of the internalization and recycling of neurokinin 1 receptors in rat dorsal horn neuronsXueren Wang
Neuroenteric Disease Program, CURE Digestive Diseases Research Center, Department of Medicine, University of California at Los Angeles, 90095, USA
Brain Res 944:239-47. 2002..These results show that NK1R internalization and recycling are considerably faster in dorsal horn neurons than in cultured cells, and that most NK1Rs in dorsal horn neurons are internalized when NK1R-mediated hyperalgesia is more severe...
- Impact of substance P receptor antagonism on the serotonin and norepinephrine systems: relevance to the antidepressant/anxiolytic responsePierre Blier
University of Ottawa Institute of Mental Health Research, Ottawa, ON
J Psychiatry Neurosci 29:208-18. 2004..Taken together, these observations strongly suggest that NK1 antagonists could become a new class of antidepressant and anxiolytic agents...
- Synthesis and characterization of a potent, selective, radiolabeled substance-P antagonist for NK1 receptor quantitation: ([18F]SPA-RQ)Olof Solin
Turku PET Centre, Turku, Finland
Mol Imaging Biol 6:373-84. 2004..To develop and characterize a radiolabelled Substance-P antagonist useful for quantitation of neurokinin-1 receptors in the brain via PET imaging...
- Partial sciatic nerve injury in the mouse as a model of neuropathic pain: behavioral and neuroanatomical correlatesA B Malmberg
Department of Anatomy, W M Keck Foundation Center for Integrative Neuroscience, University of California, San Francisco 94143 0452, USA
Pain 76:215-22. 1998..These results establish a valuable model for future studies of the biochemical basis of neuropathic pain in mice with specific gene modifications...
- Neuropeptides activate human mast cell degranulation and chemokine productionMarianna Kulka
National Research Council Canada, Room 432, 550 University Avenue, Charlottetown, PE, Canada
Immunology 123:398-410. 2008..These results are likely to have direct relevance to neuronally induced inflammatory diseases...
- Inhibition of hyperalgesia by ablation of lamina I spinal neurons expressing the substance P receptorP W Mantyh
Molecular Neurobiology Laboratory 151, Veterans Administration Medical Center, Minneapolis, MN 55417, USA
Science 278:275-9. 1997..Thus, lamina I spinal cord neurons that express the substance P receptor play a pivotal role in the transmission of highly noxious stimuli and the maintenance of hyperalgesia...
- Neurogenic amplification of immune complex inflammationC R Bozic
Perlmutter Laboratory, Children s Hospital, 300 Longwood Avenue, Boston, MA 02115, USA
Science 273:1722-5. 1996..Immunoreactive substance P was measurable in fluids lining the lung at time points before neutrophil influx and may thus be involved in an early step in the inflammatory response to immune complexes in the lung...
- Superficial NK1-expressing neurons control spinal excitability through activation of descending pathwaysRie Suzuki
Department of Pharmacology, University College London, Gower Street, London WC1E 6BT, UK
Nat Neurosci 5:1319-26. 2002....
- Neurokinin-1 receptor-expressing neurons in the amygdala modulate morphine reward and anxiety behaviors in the mouseChristopher A Gadd
Department of Anatomy and Developmental Biology, University College London, London, WC1E 6BT, United Kingdom
J Neurosci 23:8271-80. 2003....
- Expression of functional NK1 receptors in human alveolar macrophages: superoxide anion production, cytokine release and involvement of NF-kappaB pathwayClaudio Bardelli
Department of Medical Sciences, School of Medicine, University of Piemonte Orientale A Avogadro, Via Solaroli, 17, 28100 Novara, Italy
Br J Pharmacol 145:385-96. 2005..5 These results clearly indicate that human AMs possess functional NK-1R on their surface, which are upregulated in healthy smokers, providing new insights on the mechanisms involved in tobacco smoke toxicity...
- Substance P and neurokinin A mediate sensory synaptic transmission in young rat dorsal horn neuronsP Li
Department of Anesthesiology, Washington University Pain Center, Washington University School of Medicine, St. Louis, MO 63110, USA
Brain Res Bull 55:521-31. 2001..The present study provides electrophysiological evidence that suggests the possible contribution of SP and NKA to sensory synaptic transmission between primary afferent fibers and dorsal horn neurons...
- Disruption of noradrenergic transmission and the behavioural response to a novel environment in NK1R-/- miceAmy S Fisher
Department of Anatomy and Development Biology, University College London, Gower Street, London WC1E 6BT, UK
Eur J Neurosci 25:1195-204. 2007..These changes could contribute to the difference in the behavioural phenotypes...
- Nerve growth factor and nerve growth factor receptors in respiratory syncytial virus-infected lungsChengping Hu
Department of Pediatrics, University of Miami School of Medicine, Miami, Florida 33136, USA
Am J Physiol Lung Cell Mol Physiol 283:L494-502. 2002..These data indicate that expression of NGF and its receptors in the lungs declines physiologically with age but is upregulated by RSV and is a major determinant of neurogenic inflammation...
- The role of the tachykinin NK1 receptor in airway changes in a mouse model of allergic asthmaKatelijne O De Swert
Department of Respiratory Diseases, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium
J Allergy Clin Immunol 113:1093-9. 2004..Human data suggest a role for these peptides in asthma, but the exact role of tachykinins and their receptors in allergic airway inflammation is still a matter of debate...
- The oral neurokinin-1 antagonist aprepitant for the prevention of chemotherapy-induced nausea and vomiting: a multinational, randomized, double-blind, placebo-controlled trial in patients receiving high-dose cisplatin--the Aprepitant Protocol 052 Study GrPaul J Hesketh
Caritas St Elizabeth s Medical Center, Brighton, MA 02135 2997, USA
J Clin Oncol 21:4112-9. 2003....
- The molecular dynamics of pain controlS P Hunt
Department of Anatomy and Developmental Biology, Medawar Building, University College London, Gower Street, London WC1E 6BT, UK
Nat Rev Neurosci 2:83-91. 2001..These new insights into pain processing will significantly alter our approach to pain control and the development of new analgesics...
- Soma size distinguishes projection neurons from neurokinin 1 receptor-expressing interneurons in lamina I of the rat lumbar spinal dorsal hornK S Al Ghamdi
Neuroscience and Molecular Pharmacology, Faculty of Biomedical and Life Sciences, West Medical Building, University Avenue, University of Glasgow, Glasgow G12 8QQ, UK
Neuroscience 164:1794-804. 2009..Since almost all of the NK1r-immunoreactive cells with soma size >200 microm(2) were retrogradely labelled, cells of this type can be identified as projection cells in anatomical studies...
- Distinct mechanism for antidepressant activity by blockade of central substance P receptorsM S Kramer
Merck Research Laboratories, West Point, PA 19456, USA
Science 281:1640-5. 1998..These findings suggest that substance P may play an important role in psychiatric disorders...
- Contribution of neuroimmune mechanisms to airway inflammation and remodeling during and after respiratory syncytial virus infectionGiovanni Piedimonte
Department of Pediatrics, Batchelor Children s Research Institute, University of Miami School of Medicine, 1580 NW Tenth Avenue, Miami, FL 33136, USA
Pediatr Infect Dis J 22:S66-74; discussion S74-5. 2003..On the basis of these observations, we postulate that changes of neurotrophin expression in the respiratory tract may represent an important link between early life viral infections and childhood asthma...
- Large projection neurons in lamina I of the rat spinal cord that lack the neurokinin 1 receptor are densely innervated by VGLUT2-containing axons and possess GluR4-containing AMPA receptorsErika Polgár
Faculty of Biomedical and Life Sciences, University of Glasgow, Glasgow, United Kingdom
J Neurosci 28:13150-60. 2008..Our results also provide the first evidence that postsynaptic GluR4-containing AMPA receptors are involved in spinal nociceptive transmission...
- The neurokinin 1 receptor: a potential new target for anti-platelet therapy?Sarah Jones
School of Biological Sciences, University of Reading, Whiteknights, Reading, Berkshire RG6 6AJ, UK
Curr Opin Pharmacol 8:114-9. 2008..The pro-thrombotic effects of tachykinins on platelets are mediated through the neurokinin 1 receptor, which may therefore offer a novel therapeutic drug target in the prevention and the treatment of arterial thrombosis...
- Detection of full-length and truncated neurokinin-1 receptor mRNA expression in human brain regionsJian Ping Lai
Division of Allergy and Immunology, Joseph Stokes Jr Research Institute at The Children s Hospital of Philadelphia, Department of Pediatrics, University of Pennsylvania Medical School, Philadelphia, PA 19104, USA
J Neurosci Methods 168:127-33. 2008....
- Morphology and neurokinin 1 receptor expression of spinothalamic lamina I neurons in the rat spinal cordXiao Hong Yu
Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec H3G 1Y6, Canada
J Comp Neurol 491:56-68. 2005..As in the monkey, most pyramidal STT neurons did not express NK-1r. These results provide further evidence that distinct morphological types of neurons differ in phenotype but not in their projection pattern...
- Neurokinin 1 receptors trigger overlapping stimulation and inhibition of CaV2.3 (R-type) calcium channelsUlises Meza
Department of Biology, Utah State University, 5305 Old Main Hill, Logan, UT 84322, USA
Mol Pharmacol 71:284-93. 2007..This new information concerning R-type calcium channels and NK1 receptors may help in understanding nociception, synaptic plasticity, and other physiological processes...
- The role of neurokinin 1 receptors in the maintenance of visceral hyperalgesia induced by repeated stress in ratsSylvie Bradesi
Center for Neurovisceral Sciences and Women s Health, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA
Gastroenterology 130:1729-42. 2006The neurokinin 1 receptors (NK(1)Rs) and substance P (SP) have been implicated in the stress and/or pain pathways involved in chronic pain conditions...
- The NK1 receptor is essential for the full expression of noxious inhibitory controls in the mouseH Bester
Department of Anatomy and Developmental Biology, University College London, London WC1E 6BT, United Kingdom
J Neurosci 21:1039-46. 2001..The present study demonstrates that the NK1 receptor is essential for the full development of noxiously evoked descending inhibition...
- Clinical experience with substance P receptor (NK1) antagonists in depressionK Ranga
Department of Psychiatry, Duke University Medical Center, Durham, NC 27715, USA
J Clin Psychiatry 63:25-9. 2002..Future trials with SPAs will focus on the identification of appropriate patients and drug regimens and will also define the role of these agents in the treatment of depression...
- Cutting edge: hemokinin has substance P-like function and expression in inflammationAhmed Metwali
Department of Internal Medicine, Division of Gastroenterology Hepatology, University of Iowa, Iowa City, IA 52242, USA
J Immunol 172:6528-32. 2004..Two distinct but functionally overlapping tachykinins govern inflammation through NK-1R at sites of chronic inflammation...
- Efficient synthesis of novel NK1 receptor antagonists: selective 1,4-addition of grignard reagents to 6-chloronicotinic acid derivativesFabienne Hoffmann-Emery
F Hoffmann La Roche Ltd, Pharmaceuticals Division, Safety and Technical Sciences, Synthesis and Process Research, Grenzacherstrasse 124, CH 4070 Basel, Switzerland
J Org Chem 71:2000-8. 2006....
- Involvement of the second extracellular loop (E2) of the neurokinin-1 receptor in the binding of substance P. Photoaffinity labeling and modeling studiesOlivier Lequin
Unité Mixte de Recherches 7613 CNRS, Université Paul et Marie Curie, 4 place Jussieu, 75252 Paris Cedex 05, France
J Biol Chem 277:22386-94. 2002....
- Identification of single-nucleotide polymorphisms of the human neurokinin 1 receptor gene and pharmacological characterization of a Y192H variantG P Randolph
CV CNS Biological Research and Discovery Technologies, Schering Plough Research Institute, Kenilworth, NJ 07033, USA
Pharmacogenomics J 4:394-402. 2004..In all cases the Y192H variant was found to display properties similar to those of the wild-type receptor...
- Neurokinin 1 receptor antagonism as a possible therapy for alcoholismDavid T George
Laboratory of Clinical and Translational Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA
Science 319:1536-9. 2008..Thus, as assessed by these surrogate markers of efficacy, NK1R antagonism warrants further investigation as a treatment in alcoholism...
- The triple neurokinin-receptor antagonist CS-003 inhibits neurokinin A-induced bronchoconstriction in patients with asthmaV Schelfhout
Department of Respiratory Diseases, Ghent University Hospital, De Pintelaan 185, Ghent, Belgium
Pulm Pharmacol Ther 19:413-8. 2006..This did not occur under placebo treatment. A single dose of 200 mg CS-003 protected significantly against NKA-induced bronchoconstriction at 1 and 8h post-dose in mild asthmatics...
- Genetic and pharmacological disruption of neurokinin 1 receptor function decreases anxiety-related behaviors and increases serotonergic functionL Santarelli
Center for Neurobiology and Behavior, Columbia University, New York, NY 10032, USA
Proc Natl Acad Sci U S A 98:1912-7. 2001..Together these results indicate that the SP system powerfully modulates anxiety and suggest that this effect is at least in part mediated by changes in the 5-HT system...
- Neurokinin receptor 1-expressing spinal cord neurons in lamina I and III/IV of postnatal rats receive inputs from capsaicin sensitive fibersCharalampos Labrakakis
Department of Physiology and Cellular Biophysics and the Center of Neurobiology and Behavior, Columbia University, New York, NY, USA
Neurosci Lett 352:121-4. 2003....
- Targeting neurokinin-1 receptor-expressing neurons with [Sar9,Met(O2)11 substance P-saporinR G Wiley
Neurology Service 127, VAMC, Nashville, TN 37212 2637, USA
Neurosci Lett 277:1-4. 1999..SSP-saporin will be useful in larger species and for intraparenchymal injections...
- Neurokinin-1 receptor blockade and murine lung tumorigenesisMonica Lucattelli
Department of Physiopathology, Experimental Medicine, and Public Health, University of Siena, Siena, Italy
Am J Respir Crit Care Med 174:674-83. 2006..However, the data supporting this sequence are largely circumstantial and the almost impossible task of identifying these lesions before resection rules out any longitudinal study in humans...
- Visualization and quantification of neurokinin-1 (NK1) receptors in the human brainJarmo Hietala
Neuropsychiatric Imaging, Turku PET Centre, Turku University Central Hospital, Finland
Mol Imaging Biol 7:262-72. 2005....
- Imaging substance P receptors (NK1) in the living human brain using positron emission tomographyRichard Hargreaves
Merck Research Laboratories, West Point, PA 19486, USA
J Clin Psychiatry 63:18-24. 2002..Future PET imaging studies will focus on quantification of NK1 receptor expression in depressed patients, both before and after successful treatment with antidepressants...
- Neurokinin-1 receptor antagonists CP-96,345 and L-733,060 protect mice from cytokine-mediated liver injuryRenate Bang
Institute of Experimental and Clinical Pharmacology and Toxicology, University of Erlangen Nuremberg, Erlangen, Germany
J Pharmacol Exp Ther 305:31-9. 2003..NK-1 receptor antagonists might be potent drugs for treatment of inflammatory liver disease, most likely by inhibiting SP effects...
- Neurokinin-1 (NK-1) receptor is required in antigen-induced cystitisR Saban
Department of Internal Medicine, Division of Gastroenterology and Hepatology, University of Texas Medical Branch, Galveston, Texas, 77555 0632, USA
Am J Pathol 156:775-80. 2000..This work presents the first evidence of participation of NK-1 receptors in cystitis and a mandatory participation of these receptors on the chain of events linking mast cell degranulation and inflammation...
- Substance P dependence of endosomal fusion during bladder inflammationT G Hammond
Departments of Medicine and Surgery, Tulane University Medical Center, Tulane Environmental Astrobiology Center, Center for Bioenvironmental Research, and Veterans Affairs Medical Center, New Orleans, LA 70112
Am J Physiol Renal Physiol 278:F440-51. 2000..This suggests that NK1R can change the fusion properties of membranes in which it resides...
- Neurokinin 1 receptor-expressing projection neurons in laminae III and IV of the rat spinal cord have synaptic AMPA receptors that contain GluR2, GluR3 and GluR4 subunitsAndrew J Todd
Neuroscience and Molecular Pharmacology, Faculty of Biomedical and Life Sciences, University of Glasgow, Glasgow, UK
Eur J Neurosci 29:718-26. 2009..These results show that synaptic AMPArs on the dendrites of the lamina III/IV NK1r projection neurons contain GluR2, GluR3 and GluR4, but not GluR1 subunits...
- Blockade of substance P (neurokinin 1) receptors enhances extracellular serotonin when combined with a selective serotonin reuptake inhibitor: an in vivo microdialysis study in miceBruno P Guiard
Laboratoire de Neuropharmacologie EA 3544 MJENR, Faculté de Pharmacie IFR75 Institut de Signalisation et d Innovation Thérapeutique, Universite Paris Sud, Chatenay Malabry, France
J Neurochem 89:54-63. 2004..p.) reversed this effect. The present findings suggest that NK1 receptor antagonists, when combined with a SSRI, augment 5-HT release by modulating substance P/5-HT interactions in the dorsal raphe nucleus...
- Neurokinin 1 receptors and neprilysin modulation of mouse bladder gene regulationIgor Dozmorov
Oklahoma Medical Research Foundation, Microarray Research Facility, Oklahoma City, USA
Physiol Genomics 12:239-50. 2003....
- In vivo pain-inhibitory role of nociceptin/orphanin FQ in spinal cordMakoto Inoue
Division of Molecular Pharmacology and Neuroscience, Nagasaki University Graduate School of Biomedical Sciences, 1 14 Bunkyo machi, Nagasaki 852 8521, Japan
J Pharmacol Exp Ther 305:495-501. 2003..All these findings suggest that the N/OFQ-ergic neuron may play an in vivo inhibitory role on the second-order neurons for primary polymodal substance P-ergic fibers in the spinal cord...
- Human positron emission tomography studies of brain neurokinin 1 receptor occupancy by aprepitantMats Bergstrom
Uppsala Positron Emission Tomography Centre, Uppsala, Sweden
Biol Psychiatry 55:1007-12. 2004....
- The substance P receptor is necessary for a normal granulomatous response in murine schistosomiasis mansoniA M Blum
Division of Gastroenterology Hepatology, Department of Internal Medicine, University of Iowa, Iowa City, IA 52242, USA
J Immunol 162:6080-5. 1999..These results provide further evidence that in murine schistosomiasis SPr is displayed commonly on granuloma inflammatory cells and is important for granuloma development and expression of IFN-gamma circuitry in this natural infection...
- Expression of tachykinin NK1 receptor mRNA in dorsal root ganglia of the mouseT Andoh
Department of Applied Pharmacology, Toyama Medical and Pharmaceutical University, Japan
Brain Res Mol Brain Res 35:329-32. 1996..The present results suggest that NK1 receptor mRNA is expressed in the mouse DRG, although the level is relatively low...
- Collateral projections of neurons in laminae I, III, and IV of rat spinal cord to thalamus, periaqueductal gray matter, and lateral parabrachial areaKhulood M Al-Khater
Neuroscience and Molecular Pharmacology, Faculty of Biomedical and Life Sciences, University of Glasgow, Glasgow, UK
J Comp Neurol 515:629-46. 2009..These results confirm that neurons in these laminae have extensive collateral projections and suggest that different neuronal subpopulations in lamina I have characteristic patterns of supraspinal projection...
- Morphological characterization of spinal cord dorsal horn lamina I neurons projecting to the parabrachial nucleus in the ratL Almarestani
Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec H3G 1Y6, Canada
J Comp Neurol 504:287-97. 2007..In addition, our study provides further evidence that these distinct morphological types of neurons differ in their phenotypic properties, but not in their projection patterns...
- [3H]GR205171 displays similar NK1 receptor binding profile in gerbil and human brainCristiana Griffante
Psychiatry Centre of Excellence for Drug Discovery, GlaxoSmithKline Group, Medicines Research Centre, 37135 Verona, Italy
Br J Pharmacol 148:39-45. 2006....
- The murine neurokinin NK1 receptor gene contributes to the adult hypoxic facilitation of ventilationKrzysztof Ptak
Physiologie Neurovégétative, UMR 6153 CNRS INRA, Faculté des Sciences de St Jérôme, 13397 Marseille Cedex 20, France
Eur J Neurosci 16:2245-52. 2002..However, NK1 receptors are not obligatory for the prenatal development of the respiratory network, for the production of the rhythm, or for the regulation of breathing by short-lasting hypoxia in neonates...
- Functional expression of neurokinin 1 receptors on mast cells induced by IL-4 and stem cell factorHanneke P M van der Kleij
Department of Pharmacology and Pathophysiology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands
J Immunol 171:2074-9. 2003..In conclusion, BMMC were shown to express NK(1) receptors upon IL-4/SCF coculture. This expression of NK(1) receptors has been demonstrated to be of functional relevance and leads to an increase in the sensitivity of BMMC to substance P...
- Brain uptake and receptor binding of two [11C]labelled selective high affinity NK1-antagonists, GR203040 and GR205171--PET studies in rhesus monkeyM Bergstrom
Uppsala University PET Centre, University Hospital, Sweden
Neuropharmacology 39:664-70. 2000..The pre-treatment dose of cold GR205171 needed for 50% inhibition of binding was less than 0.04 mg/kg. The studies indicated that [11C]GR205171 could be used for the in vivo characterisation of NK1-receptor binding...
- Neurogenic inflammation in acute pancreatitisAkhil Hegde
JOP 6:417-21. 2005..This editorial focuses on the role of substance P and its receptors in the development of acute pancreatitis...
- Noradrenaline is necessary for the hedonic properties of addictive drugsLuc Jasmin
Department of Neurological Surgery and W M Keck Foundation Center for Integrative Neuroscience, University of California San Francisco, San Francisco, CA 94143, USA
Vascul Pharmacol 45:243-50. 2006..The reversibility of this phenomenon, by restoring NA, indicates that even when this behavioral deficit is genetically determined it can be reversed...
- A population of large lamina I projection neurons with selective inhibitory input in rat spinal cordZ Puskar
Spinal Cord Group, IBLS, University of Glasgow, G12 8QQ, Glasgow, UK
Neuroscience 102:167-76. 2001..These cells are under powerful inhibitory control, and the study provides further evidence that inhibitory circuits in the dorsal horn are organized in a specific manner...
- The neuropeptide substance P is a critical mediator of burn-induced acute lung injurySelena Wei Shan Sio
Department of Pharmacology, National University of Singapore, Singapore
J Immunol 180:8333-41. 2008..The present findings show for the first time the role of SP in contributing to exaggerated pulmonary inflammatory damage after burn injury via activation of NK1R signaling...
- P-Glycoprotein efflux reduces the brain concentration of the substance P (NK1 receptor) antagonists SR140333 and GR205171: a comparative study using mdr1a-/- and mdr1a+/+ miceN M J Rupniak
Department of Pharmacology, Merck Sharp and Dohme Research Laboratories, Neuroscience Research Centre, Harlow, Essex, UK
Behav Pharmacol 14:457-63. 2003..These findings suggest that P-gp deficient mice may have useful applications in behavioural pharmacology studies, especially when highly brain-penetrant compounds are not yet available...
- Substance P receptor-expressing dorsal horn neurons: lessons from the targeted cytotoxin, substance P-saporinRonald G Wiley
Laboratory of Experimental Neurology, Neurology Service, VA TVHS, 1310 24th Avenue, South Nashville, TN 37212 2637, USA
Pain 136:7-10. 2008
- Cyclopentane-based human NK1 antagonists. Part 2: development of potent, orally active, water-soluble derivativesLaura C Meurer
Department of Medicinal Chemistry, Merck Research Laboratories, Rahway, NJ 07065, USA
Bioorg Med Chem Lett 16:4504-11. 2006..Sub-nanomolar hNK1 binding was achieved and oral activity comparable to Aprepitant in two in vivo models will be described...
- De novo expression of the neurokinin 1 receptor in spinal lamina I pyramidal neurons in polyarthritisL Almarestani
Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada
J Comp Neurol 514:284-95. 2009....
- Lack of efficacy of the substance p (neurokinin1 receptor) antagonist aprepitant in the treatment of major depressive disorderMartin Keller
Department of Psychiatry and Human Behavior, Brown University, Providence, Rhode Island, USA
Biol Psychiatry 59:216-23. 2006..An early clinical trial suggested that the substance P (neurokinin(1) receptor) antagonist, aprepitant, might provide a unique mechanism of antidepressant activity. Phase III trials were conducted to confirm these findings...
- Substance P acts via the neurokinin receptor 1 to elicit bronchoconstriction, oxidative stress, and upregulated ICAM-1 expression after oil smoke exposurePing Chia Li
Dept of Occupational Therapy, I Shou Univ, No 8 E Da Road, Jiau Shu Tsuen, Yan Chau Shiang, Kaohsiung County 824, Tainan City, Republic of China Taiwan
Am J Physiol Lung Cell Mol Physiol 294:L912-20. 2008..These findings suggest that SP acts via the NK-1 receptor to provoke neurogenic inflammation, oxidative stress, and ICAM-1 expression after OSE in rats...
- The role of neural inflammation in asthma and chronic obstructive pulmonary diseaseGuy F Joos
Department of Respiratory Diseases, Ghent University Hospital, De Pintelaan 185, B 9000 Ghent, Belgium
Ann N Y Acad Sci 992:218-30. 2003..It is suggested that dual NK(1)/NK(2) and triple NK(1)/NK(2)/NK(3) tachykinin receptor antagonists have potential in the treatment of obstructive airway diseases...
- Inflammation-induced up-regulation of neurokinin 1 receptors in rat glabrous skinSusan M Carlton
Department of Anatomy and Neurosciences, Marine Biomedical Institute, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555 1069, USA
Neurosci Lett 326:29-32. 2002....
- Elucidating the antidepressant actions of substance P (NK1 receptor) antagonistsNadia M J Rupniak
Merck Sharp and Dohme Research Laboratories, Neuroscience Research Centre, Harlow, Essex, UK
Curr Opin Investig Drugs 3:257-61. 2002..Additional studies are needed to explore these hypothesesfurther...
- Metalloelastase in lungs and alveolar macrophages is modulated by extracellular substance P in miceJ Xu
Pathophysiology Program, Lovelace Respiratory Research Institute, Albuquerque, New Mexico 87108, USA
Am J Physiol Lung Cell Mol Physiol 295:L162-70. 2008..These findings suggest that SP has a modulatory effect on pulmonary MMP-12 by acting on NK1R to trigger MMP-12 syntheses in the AMs...
- Selective innervation of lamina I projection neurones that possess the neurokinin 1 receptor by serotonin-containing axons in the rat spinal cordE Polgar
Spinal Cord Group, IBLS, University of Glasgow, UK
Neuroscience 109:799-809. 2002..innervation of lamina I projection neurones in the rat spinal cord is related to expression of neurokinin 1 receptors, but not to morphology, and that (at least on heavily innervated neurones) most serotonin-containing ..
- Anti-nociceptive effects of selectively destroying substance P receptor-expressing dorsal horn neurons using [Sar9,Met(O2)11]-substance P-saporin: behavioral and anatomical analysesR G Wiley
Laboratory of Experimental Neurology, VA TVHS, Nashville, TN 37212 2637, USA
Neuroscience 146:1333-45. 2007..SSP-sap is an attractive agent for possible treatment of chronic pain...
- Destruction of neurokinin-1 receptor expressing cells in vitro and in vivo using substance P-saporin in ratsR G Wiley
Neurology Service, VAMC, Nashville, TN 37212 2637, USA
Neurosci Lett 230:97-100. 1997..Injection of SP-SAP into the striatum selectively destroyed NK-1 receptor expressing interneurons. These results show that SP-SAP will be useful for studying the function of NK-1 receptor expressing neurons...
- Tachykinins: role in detrusor overactivity?Karl Erik Andersson
Eur Urol 49:423-5. 2006
- Effects of analgesic or antidepressant drugs on pain- or stress-evoked hippocampal and spinal neurokinin-1 receptor and brain-derived neurotrophic factor gene expression in the ratVanja Duric
Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, 3901 Rainbow Blvd, MSN 1018, Kansas City, KS 66160, USA
J Pharmacol Exp Ther 319:1235-43. 2006....
- Role of the neurogenic inflammatory pathway in the genital tract immune responseRoger G Rank; Fiscal Year: 2010....
- Surgical Wound Repair: Role of A Neuroendothelial AxisNICOLE SIMONE GIBRAN; Fiscal Year: 2010..We will employ siRNA to deplete neuropeptide receptors on endothelial cells to further define neural modulation of endothelial cell inflammatory responses, migration and proliferation. ..
- Presynaptic NMDAR Regulation of Substance P Release in the RVM After InjuryUCHECHUKWU PATRICK MADUKA; Fiscal Year: 2013....
- REGULATION OF CELLULAR RESPONSES TO NEUROPEPTIDESNigel W Bunnett; Fiscal Year: 2010..For type specifications, see Specific Instructions onpage 10.) RESEARCH GRANT TABLE OF CONTENTS PAGE NUMBERS Face page 1 Description, ..
- GENETIC ORGANIZATION OF RESPIRATORY CIRCUITS IN MOUSE BRAINSTEMPaul Gray; Fiscal Year: 2013..Understanding the genetic organization of the brainstem neurons that generate breathing is essential for the diagnosis and treatment of breathing disorders. ..
- Effect of Prenatal Nicotinic Exposure on Control of Hypoxic Ventilatory ResponseFadi Xu; Fiscal Year: 2013....
- Use of Substance P antagonists to regulate the skin immune functionAdriana T Larregina; Fiscal Year: 2013..Specific Aim 3: To analyze, the possibility of using local administration of specific NK1R antagonists to suppress CHS by down-regulating the T cell-stimulatory function of sDCs and their precursors. ..
- NMDA Receptors in Primary AfferentsJames A McRoberts; Fiscal Year: 2013..Using rodent models, we will test the predictions that neuropathic and visceral pain increase NMDA-induced SP release, and decrease after selective knockdown of NMDARs in primary afferents. ..
- Ponce School of Medicine - Moffitt Cancer Center PartnershipWARREN JACKSON PLEDGER; Fiscal Year: 2011..Appleyard in the Minority-Serving Institute (MSI) to successfully compete for a R01 grant from the National Cancer Institute (NCI) and will increase the quality of graduate education at the MSI. ..
- Sigma 1 receptor as a master regulator of pronociceptive protein trafficking in tJay Yang; Fiscal Year: 2013....
- Anti-HIV Neuroimmunomodulatory Therapy with Neurokinin-1 (NK1-R) AntagonistsSTEVEN DANIEL DOUGLAS; Fiscal Year: 2013..This NK1RA has activity as an antiviral HIV agent that improves innate immunity (Natural Killer cells) and has positive neurobehavioral effects. NK1RA are a potential novel therapy for neuroAIDS...
- Neural Mechanisms of ItchEarl E Carstens; Fiscal Year: 2013..These hypotheses will be addressed using two murine models of chronic itch, the NC "itchy" mouse strain, and experimental dry skin. ..
- Interdependence among neuromodulators of ventilatory controlHubert V Forster; Fiscal Year: 2013....
- Functional dissection of the Tac2-Nk3R pathway to prevent fear consolidationKerry J Ressler; Fiscal Year: 2013..These findings will energize and support a new research program aimed at translating the modulation of the Tac2/Nk3 pathway to provide novel approaches to intervention following fear and trauma exposure for the prevention of the PTSD. ..
- Lethal H5N1 Virus Infection and Respiratory DisordersFadi Xu; Fiscal Year: 2013....
- New Neural Targets for Opioid Use Disorders: Human StudiesSharon L Walsh; Fiscal Year: 2010..Thus, these studies, conducted in healthy humans, will provide fundamental information regarding the potential for this system as a target for development of new treatment agents for opioid use disorders. ..
- Truncated NK1R in GBM: Pharmacology and Relationship with Patient SurvivalMadan M Kwatra; Fiscal Year: 2013..The unique combination of the PI's expertise in NK1R biology and the resources available at Duke's Preston Robert Tisch Brain Tumor Center ensures successful completion of these studies. ..
- Role of Substance P in Intestinal InflammationCharalabos Pothoulakis; Fiscal Year: 2013..Part of this project will also examine whether SP-mediated responses in human preadipocytes influence pathways that link colitis with the metabolic syndrome and insulin resistance. ..
- Substance P exacerbation of CNS inflammationMARIO TOMAS PHILIPP; Fiscal Year: 2013....
- Development of Topical Neuroinflammatory InhibitorsMANDIP SACHDEVA; Fiscal Year: 2005..The results of these studies are intended to provide the basic information required for the development of novel skin disorders. ..
- CD163 in HIV ImmunopathogenesisSTEVEN DANIEL DOUGLAS; Fiscal Year: 2013..This R21 focuses on the mechanisms of HIV infection in macrophages and has direct implications for development of novel HIV therapies. ..
- Neuronal Plasticity Related to TMD and FibromyalgiaDean Dessem; Fiscal Year: 2006..Because a gender difference is reported for TMD and FM, both hypotheses will be tested in males, estrous females and diestrous females. ..
- NEUROGENIC MECHANISMS OF INTESTINAL INFLAMMATIONEileen Grady; Fiscal Year: 2006..Together, the results of these experiments will provide new insights into peptide signaling, generate novel information about mechanisms of intestinal inflammation, and suggest new strategies for therapy. ..
- Nanoparticle mediated in vivo cell-type specific drug delivery for pain reliefZhigang David Luo; Fiscal Year: 2013..Promising data derived from this project will be used for the application of a larger scale NIH R01 project related to application of siRNA/nanoparticles in targeted gene silencing and pain relief. ..
- NOCICEPTIVE SENSORY REGULATION OF NEUROKININ RECEPTORSKENNETH MC CARSON; Fiscal Year: 2004..abstract_text> ..
- Substance P & the Regulation of Intestinal InflammationJoel Weinstock; Fiscal Year: 2009..Strategies aimed at modulating NK-1 R function in the gut could prove therapeutically beneficial for IBD. ..
- DORSAL SPINAL CORD STIMULATION--VASODILATOR MECHANISMSRobert Foreman; Fiscal Year: 2001....
- NEUROTRANSMITTER FUNCTION IN SPINAL SENSORY TRANSMISSIONThomas Jessell; Fiscal Year: 1993..the mechanisms of signalling evoked by substance P in these two classes of neurons will be examined in detail...
- NORADRENERGIC DYSFUNCTION--A MODEL OF FIBROMYALGIA PAINLuc Jasmin; Fiscal Year: 2001..abstract_text> ..
- Magnesium Deficiency: Effect on Bone and MineralRobert Rude; Fiscal Year: 2004..These studies should substantiate our hypothesis that Mg depletion contributes to osteoporosis and provide mechanistic explanations. ..
- MECHANISMS OF SYNAPTIC MODULATION IN SYMPATHETIC NEURONSMark Simmons; Fiscal Year: 2000..internalization of the substance P receptor in single neurons? 2) What are the requirements for resensitization of the substance P receptor? 3) What is the mechanism for desensitization of responses to gonadotrophin-releasing hormone? ..
- EFFECT OF DENERVATION ON THE FUNCTION OF THE AIRWAYSJ PEREZ FONTAN; Fiscal Year: 2004..abstract_text> ..
- The Roles of Heme Oxygenase in PainDavid Clark; Fiscal Year: 2005....
- MECHANISMS OF G PROTEIN COUPLED RECEPTOR REGULATIONLAWRENCE BARAK; Fiscal Year: 2002..Insight gained from them should provide a foundation for the development of new treatment regiments that target diseases such as hypertension, heart failure, and chronic pain syndromes. ..
- NEUROCHEMISTRY OF NOCICEPTIONPatrick Mantyh; Fiscal Year: 2002....
- MOLECULAR PATHOGENESIS OF RADIATION ENTEROPATHYMartin Hauer Jensen; Fiscal Year: 2005..This project may facilitate development of specific strategies to minimize intestinal radiation toxicity, thereby making radiation therapy safer and more effective. ..
- THERMAL HYPERALGESIA IN AGEDWILLIAM CRUCE; Fiscal Year: 1999..The long term goals of the investigators are to study neuropathic pain in aged animals so that we have a better basis on which to design treatments for this condition. ..
- CENTRAL INTERACTION OF BARORECEPTOR & SOMATIC AFFERENTSJeffrey Potts; Fiscal Year: 2007..unreadable] [unreadable]..
- MACROPHAGE ACTIVATION & SUBSTANCE P RECEPTOR EXPRESSIONKENNETH BOST; Fiscal Year: 2006..Taken together, these studies will demonstrate that substance P is an integral part of the host immune response against pathogens. ..
- Targeting Neurons Involved in Chronic Pain TransmissionDOUGLAS LAPPI; Fiscal Year: 2001..Additionally, an expression system that can diminish rather than destroy a cell's function would have great possibility in the treatment of disease. ..
- Lateral Pontine Neurons in the Control of BreathingDONALD MC CRIMMON; Fiscal Year: 2007..unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
- GASTROINTESTINAL MOTOR EFFECTS OF IONIZING RADIATIONMary Otterson; Fiscal Year: 2000..The primary objectives of this research proposal are 1) to explore the role of central and peripheral neurokinin 1 receptors in the contractile changes produced by irradiation, 2) to understand the mechanisms of the coordination ..
- STIMULUS-SPECIFIC SI CORTICOCORTICAL INTERACTIONSBarry Whitsel; Fiscal Year: 2007..abstract_text> ..
- Vaccine hurdle to anthrax and the emerging immune systemPranela Rameshwar; Fiscal Year: 2006..This study will also form the basis to develop in vivo model with human hematopoietic system to study anthrax infection and also to improve responses to anthrax vaccines. ..
- BREAST CANCER/BONE MARROW STROMAL INTERACTIONSPranela Rameshwar; Fiscal Year: 2003..Since BC metastasis involves two major cell subsets, mesenchymal (stroma) and epithelial (BC), aim 4 will determine if regulation of PPT-I, NK-1 and NK-2 is tissue specific by studying their promoters in these cell subsets. ..
- CSF AND THE CENTRAL CHEMICAL CONTROL OF BREATHINGEugene Nattie; Fiscal Year: 2008..abstract_text> ..
- PHILADELPHIA PEDIATRIC AIDS CLINICAL TRIALS UNITSteven Douglas; Fiscal Year: 2006..abstract_text> ..
- MECHANISMS OF CANNABINOID'S ANTIEMETIC ACTIONSNISSAR DARMANI; Fiscal Year: 2007..The results will have important implications for the therapeutic utility of these "agonist antiemetics". [unreadable] [unreadable]..
- Spinal Opioid Release in NociceptionJuan Carlos Marvizon; Fiscal Year: 2008..Internalization of neurokinin 1 receptors and mu-opioid receptors will be used to measure neurokinin and opioid release, respectively...
- Neurokinin-1R (SP Receptor) Antagonists for HIV TherapySteven Douglas; Fiscal Year: 2008....
- Interaction of Human Immune Cells Alcohol & HIVSteven Douglas; Fiscal Year: 2005..These studies may provide new mechanistic insights related to the role of alcohol in the pathogenesis of HIV disease and AIDS and toward design of new therapeutic approaches. ..
- MECHANISMS OF CANNABINOIDS ANTIEMETIC ACTIONSNISSAR DARMANI; Fiscal Year: 2001..The results will define an important role for the cannabinoid receptors in the vomiting circuits and may implicate an antiemetic role for the endogenous cannabinoids. ..
- ORGANIZATION OF CENTRAL SYMPATHETIC PATHWAYSPATRICE GUYENET; Fiscal Year: 2008..The research will contribute to the basic physiological knowledge needed to understand how syrr pathetic tone is regulated in health and in diseases such as arrhythmias, hypertension and dysautonomias. ..
- REGULATION OF GUT SUBSTANCE P RECEPTORSSTEVEN VIGNA; Fiscal Year: 2006..These studies will lead to insight into the normal mechanisms of SP NK-1R regulation and will suggest possible mechanisms of abnormal NK-1R regulation in intestinal inflammatory diseases. ..
- Injury Induced Facilitated Neurogenic InflammationWade Kingery; Fiscal Year: 2006..abstract_text> ..
- NEURAL REGULATION OF BONE REMODELINGWade Kingery; Fiscal Year: 2008..These investigations will help to identify the sensory transmitters that modulate bone remodeling and characterize their roles in osteoporotic processes. ..
- LPS-PEPTIDE INTERACTION IN BLADDER INFLAMMATIONRicardo Saban; Fiscal Year: 2007..Information generated by this study should elucidate whether bladder inflammatory responses, regardless of etiology, occur via a common mechanism or whether the endpoints are specific for each stimulus. ..
- Neuropeptides in the pathogenesis of neurocysticercosisPrema Robinson; Fiscal Year: 2007..abstract_text> ..
- Particulate Matter Exposure: Cardiovascular MechanismsChao Yin Chen; Fiscal Year: 2008..unreadable] [unreadable]..
- CENTRAL NEURONAL MECHANISMS--DECOMPENSATED HEMORRHAGEPATRICE GUYENET; Fiscal Year: 2003..Understanding the neurophysiological mechanisms triggered by hypotensive hemorrhage should lead to improved ability to manage this all too frequent clinical problem. ..
- Urothelial Cell Physiology in Normal and Disease StatesRicardo Saban; Fiscal Year: 2005..Scott-Hultgren (Washington U) will discuss the molecular basis of persistent bladder infections. The bladder cancer discussion will be chaired by Drs. Robert Hurst (Oklahoma U) and Jenny Southgate (U. York). ..
- HIPPOCAMPAL NETWORK STRUCTURE AND FUNCTION IN EPILEPSYROBERT SLOVITER; Fiscal Year: 2006..abstract_text> ..