corticotropin receptors

Summary

Summary: Cell surface receptors that bind CORTICOTROPIN; (ACTH, adrenocorticotropic hormone) with high affinity and trigger intracellular changes. Pharmacology suggests there may be multiple ACTH receptors. An ACTH receptor has been cloned and belongs to a subfamily of G-protein-coupled receptors. In addition to the adrenal cortex, ACTH receptors are found in the brain and immune systems.

Top Publications

  1. ncbi The cloning of a family of genes that encode the melanocortin receptors
    K G Mountjoy
    Vollum Institute for Advanced Biomedical Research, Oregon Health Sciences University, Portland 97201
    Science 257:1248-51. 1992
  2. ncbi Interactions between the melanocortin system and leptin in control of sympathetic nerve traffic
    W G Haynes
    Hypertension Genetics Specialized Center of Research, Department of Internal Medicine, University of Iowa College of Medicine, Iowa City 52242, USA
    Hypertension 33:542-7. 1999
  3. ncbi Familial glucocorticoid deficiency associated with point mutation in the adrenocorticotropin receptor
    A J Clark
    Department of Endocrinology, St Bartholomew s Hospital, London, UK
    Lancet 341:461-2. 1993
  4. ncbi The melanocortin-1 receptor is a key regulator of human cutaneous pigmentation
    Z Abdel-Malek
    University of Cincinnati, Ohio, 45267 592, USA
    Pigment Cell Res 13:156-62. 2000
  5. pmc Central melanocortin receptors regulate insulin action
    S Obici
    Diabetes Research and Training Center, Albert Einstein College of Medicine, Bronx, New York, USA 10461
    J Clin Invest 108:1079-85. 2001
  6. ncbi Clinical, genetic, and functional characterization of adrenocorticotropin receptor mutations using a novel receptor assay
    Christa E Flück
    Department of Pediatrics and Metabolic Research Unit, University of California, San Francisco, California 94143 0978, USA
    J Clin Endocrinol Metab 87:4318-23. 2002
  7. pmc Hereditary isolated glucocorticoid deficiency is associated with abnormalities of the adrenocorticotropin receptor gene
    C Tsigos
    Developmental Endocrinology Branch, National Institute of Child Health and Human Development, Bethesda, Maryland 20892
    J Clin Invest 92:2458-61. 1993
  8. ncbi Role of melanocortin-4 receptors in mediating renal sympathoactivation to leptin and insulin
    Kamal Rahmouni
    Hypertension Genetics Specialized Center of Research, and Department of Internal Medicine, University of Iowa and the Veterans Administration Medical Center, Iowa City, Iowa 52242, USA
    J Neurosci 23:5998-6004. 2003
  9. ncbi Hypothalamic, metabolic, and behavioral responses to pharmacological inhibition of CNS melanocortin signaling in rats
    T Adage
    Department of Animal Physiology, University of Groningen, 9750 AA Haren, The Netherlands
    J Neurosci 21:3639-45. 2001
  10. ncbi Hypothalamic melanocortin receptors and chronic regulation of arterial pressure and renal function
    Jay J Kuo
    Department of Physiology and Biophysics, Center of Excellence in Cardiovascular Renal Research, University of Mississippi Medical Center, Jackson 39216 4505, USA
    Hypertension 41:768-74. 2003

Research Grants

  1. Primate Fetal Adrenal Development: Impact on Physiological Processes After Birth
    Eugene D Albrecht; Fiscal Year: 2013
  2. AVIDIN-BIOTIN TECHNOLOGY FOR HORMONE RECEPTOR ISOLATION
    Klaus Hofmann; Fiscal Year: 1990
  3. IDENTIFICATION OF GENE FOR ACTH-RECEPTOR BY CLONING
    JANAKIRAMAN RAMACHANDRAN; Fiscal Year: 1990
  4. MORPHINE: CNS SITES OF ANALGESIA AND ADDICTION
    YASUKO JACQUET; Fiscal Year: 1980
  5. Human Melanocortin-4 Receptor Polymorphisms
    Carrie Haskell Luevano; Fiscal Year: 2007
  6. STRUCTURAL DETERMINANTS OF NEUROENDOCRINE RECEPTORS
    Carrie Haskell Luevano; Fiscal Year: 2008
  7. 19th International Pigment Cell Conference - 2005
    Zalfa Abdel Malek; Fiscal Year: 2005
  8. Peptide Hormone Structure Function
    Victor J Hruby; Fiscal Year: 2010
  9. Molecular determinants of ACTH receptor for ligand binding
    Yingkui Yang; Fiscal Year: 2006
  10. Melanocortin-3 receptor regulation of insulin action
    Andrew Butler; Fiscal Year: 2005

Detail Information

Publications219 found, 100 shown here

  1. ncbi The cloning of a family of genes that encode the melanocortin receptors
    K G Mountjoy
    Vollum Institute for Advanced Biomedical Research, Oregon Health Sciences University, Portland 97201
    Science 257:1248-51. 1992
    ..The murine and human MSH receptors (MSH-Rs) and a human ACTH receptor (ACTH-R) were cloned. These receptors define a subfamily of receptors coupled to guanine nucleotide-binding proteins that may include the cannabinoid receptor...
  2. ncbi Interactions between the melanocortin system and leptin in control of sympathetic nerve traffic
    W G Haynes
    Hypertension Genetics Specialized Center of Research, Department of Internal Medicine, University of Iowa College of Medicine, Iowa City 52242, USA
    Hypertension 33:542-7. 1999
    ..Our data also suggest that leptin increases renal SNA through activation of hypothalamic melanocortin receptors. In contrast, sympathoactivation to thermogenic BAT by leptin appears to be independent of the melanocortin system...
  3. ncbi Familial glucocorticoid deficiency associated with point mutation in the adrenocorticotropin receptor
    A J Clark
    Department of Endocrinology, St Bartholomew s Hospital, London, UK
    Lancet 341:461-2. 1993
    ..This is only the second clinical disorder associated with a GTP-binding-protein-linked hormone-receptor mutation...
  4. ncbi The melanocortin-1 receptor is a key regulator of human cutaneous pigmentation
    Z Abdel-Malek
    University of Cincinnati, Ohio, 45267 592, USA
    Pigment Cell Res 13:156-62. 2000
    ..These results begin to elucidate the significance of MC1R variants in the function of the receptor. Our data emphasize the significance of a normally functioning MC1R in the response of melanocytes to melanocortins, ASP, and UVR...
  5. pmc Central melanocortin receptors regulate insulin action
    S Obici
    Diabetes Research and Training Center, Albert Einstein College of Medicine, Bronx, New York, USA 10461
    J Clin Invest 108:1079-85. 2001
    ..Our findings elucidate a neuroendocrine network that is likely to play a central role in the coupling of energy intake and insulin action...
  6. ncbi Clinical, genetic, and functional characterization of adrenocorticotropin receptor mutations using a novel receptor assay
    Christa E Flück
    Department of Pediatrics and Metabolic Research Unit, University of California, San Francisco, California 94143 0978, USA
    J Clin Endocrinol Metab 87:4318-23. 2002
    ..This assay provides excellent sensitivity in an easily assayed transient transfection system, providing a more rapid and efficient measurement of ACTH receptor activity...
  7. pmc Hereditary isolated glucocorticoid deficiency is associated with abnormalities of the adrenocorticotropin receptor gene
    C Tsigos
    Developmental Endocrinology Branch, National Institute of Child Health and Human Development, Bethesda, Maryland 20892
    J Clin Invest 92:2458-61. 1993
    ..We conclude that IGD in this family appears to be due to defects of the ACTH receptor gene. The oCRH test appears to be useful in ascertaining heterozygosity in this syndrome...
  8. ncbi Role of melanocortin-4 receptors in mediating renal sympathoactivation to leptin and insulin
    Kamal Rahmouni
    Hypertension Genetics Specialized Center of Research, and Department of Internal Medicine, University of Iowa and the Veterans Administration Medical Center, Iowa City, Iowa 52242, USA
    J Neurosci 23:5998-6004. 2003
    ..In addition, the renal sympathoexcitatory responses to leptin and insulin are dependent on the MC-4R, demonstrating an important role for the MC-4R in the regulation of renal sympathetic nerve outflow by leptin and insulin...
  9. ncbi Hypothalamic, metabolic, and behavioral responses to pharmacological inhibition of CNS melanocortin signaling in rats
    T Adage
    Department of Animal Physiology, University of Groningen, 9750 AA Haren, The Netherlands
    J Neurosci 21:3639-45. 2001
    ..e., CART, POMC, and NPY) and paraventricular (i.e., CRH) hypothalamus. The results indicate that reduced activity of the CNS MC pathway promotes fat deposition via both food intake-dependent and -independent mechanisms...
  10. ncbi Hypothalamic melanocortin receptors and chronic regulation of arterial pressure and renal function
    Jay J Kuo
    Department of Physiology and Biophysics, Center of Excellence in Cardiovascular Renal Research, University of Mississippi Medical Center, Jackson 39216 4505, USA
    Hypertension 41:768-74. 2003
    ..These observations are consistent with the hypothesis that an intact hypothalamic MC3/4-R may be necessary for excess weight gain to raise arterial pressure...
  11. ncbi Demonstration by transfection studies that mutations in the adrenocorticotropin receptor gene are one cause of the hereditary syndrome of glucocorticoid deficiency
    D Naville
    INSERM INRA U 418, Hopital Debrousse, Lyon, France
    J Clin Endocrinol Metab 81:1442-8. 1996
    ..For the mutant receptors, no response to physiological ACTH concentrations was detected, suggesting an impaired binding of ACTH to the receptors and/or an altered coupling to the adenylate cyclase effector...
  12. ncbi Distribution of cDNA for melanocortin receptor subtypes in human tissues
    V Chhajlani
    Department of Pharmaceutical Pharmacology, Division of Pharmaceutical Bioscience, Uppsala, Sweden
    Biochem Mol Biol Int 38:73-80. 1996
    ....
  13. ncbi Human melanocortin 1 receptor variants, receptor function and melanocyte response to UV radiation
    M Cathy Scott
    Department of Dermatology, University of Cincinnati College of Medicine, PO Box 670592, Cincinnati, Ohio 45267 0592, USA
    J Cell Sci 115:2349-55. 2002
    ..We conclude that loss-of-function mutations in the MC1R gene sensitize human melanocytes to the DNA damaging effects of UV radiation, which may increase skin cancer risk...
  14. ncbi Central melanocortin receptor agonist reduces spontaneous and scheduled meal size but does not augment duodenal preload-induced feeding inhibition
    Anthony V Azzara
    Bourne Behavioral Research Laboratory, Department of Psychiatry, NY Hospital Weill Cornell Medical College, 21 Bloomingdale Road, White Plains, NY 10605, USA
    Physiol Behav 77:411-6. 2002
    ....
  15. ncbi Regulation of the human melanocortin 1 receptor expression in epidermal melanocytes by paracrine and endocrine factors and by ultraviolet radiation
    M Cathy Scott
    Department of Dermatology, University of Cincinnati, Cincinnati, Ohio 45267 592, USA
    Pigment Cell Res 15:433-9. 2002
    ..Differences in the responses of NHM to some of these factors suggest differential regulation of MC1R gene expression, which may contribute to the variation in constitutive and UV-induced cutaneous pigmentation in humans...
  16. ncbi Anti-inflammatory potential of melanocortin receptor-directed drugs
    A Skottner
    Melacure Therapeutics AB, Ulleråkersvägen 38, SE 756 43 Uppsala, Sweden
    Ann N Y Acad Sci 994:84-9. 2003
    ....
  17. ncbi Inhibition of tumor necrosis factor-alpha stimulated NFkappaB/p65 in human keratinocytes by alpha-melanocyte stimulating hormone and adrenocorticotropic hormone peptides
    Manar Moustafa
    University of Sheffield, Section of Medicine, Division of Clinical Sciences, Northern General Hospital, Sheffield, UK
    J Invest Dermatol 119:1244-53. 2002
    ....
  18. ncbi Molecular and behavioral interactions between central melanocortins and cocaine
    John D Alvaro
    Division of Molecular Psychiatry, Abraham Ribicoff Research Facilities, Department of Psychiatry, Yale University School of Medicine, Connecticut Mental Health Center, New Haven, Connecticut 06508, USA
    J Pharmacol Exp Ther 304:391-9. 2003
    ..These data further support a role for the melanocortin-MC4-R neuropeptide system in the biochemical and behavioral effects of cocaine...
  19. ncbi Effects of acute and chronic administration of the melanocortin agonist MTII in mice with diet-induced obesity
    Dominique D Pierroz
    Division of Endocrinology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
    Diabetes 51:1337-45. 2002
    ..In conclusion, treatment with a melanocortin agonist is a promising therapeutic approach to DIO and associated insulin resistance...
  20. ncbi Evidence for expression of melanocortin-1 receptor in human sebocytes in vitro and in situ
    Markus Bohm
    Department of Dermatology and Ludwig Boltzmann Institute for Cell Biology and Immunobiology of the Skin, University of Munster, Munster, Germany
    J Invest Dermatol 118:533-9. 2002
    ..By modulating interleukin-8 secretion, alpha-melanocyte-stimulating hormone may act as a modulator of inflammatory responses in the pilosebaceous unit...
  21. ncbi Alpha-melanocyte stimulating hormone potentiates p16/CDKN2A expression in human skin after ultraviolet irradiation
    Sandra Pavey
    Joint Oncology Program, Department of Pathology, University of Queensland, Brisbane, Queensland 4006, Australia
    Cancer Res 62:875-80. 2002
    ..This link between p16 and MC1R may provide a molecular basis for the increased skin cancer risk associated with MC1R polymorphisms...
  22. ncbi Cysteine residues are involved in structure and function of melanocortin 1 receptor: Substitution of a cysteine residue in transmembrane segment two converts an agonist to antagonist
    P A Frändberg
    Division of Biological Research on Drug Dependence, Biomedical Centre, Uppsala, S 751 24, Sweden
    Biochem Biophys Res Commun 281:851-7. 2001
    ....
  23. ncbi Effects of melanocortin peptides on lipopolysaccharide/interferon-gamma-induced NF-kappaB DNA binding and nitric oxide production in macrophage-like RAW 264.7 cells: evidence for dual mechanisms of action
    I Mandrika
    Department of Pharmaceutical Pharmacology, Uppsala University, Box 591, BMC, SE-75124, Uppsala, Sweden
    Biochem Pharmacol 61:613-21. 2001
    ..We suggest that melanocortin peptides act via dual mechanisms of action: one cAMP-independent and causing inhibition of NF-kappaB translocation and the other dependent on MC(1) receptor/cAMP activation...
  24. ncbi Melanocortin-1 receptor gene variants in four Chinese ethnic populations
    S Peng
    Laboratory of Cellular and Molecular Evolution, Kunming Institute of Zoology, The Chinese Academy of Sciences
    Cell Res 11:81-4. 2001
    ..The different environments, migration and admixture of various ethnic groups in China might have impact on the observed frequency of Arg163Gln...
  25. ncbi Design of new small cyclic melanocortin receptor-binding peptides using molecular modelling: Role of the His residue in the melanocortin peptide core
    P Prusis
    Department of Pharmaceutical Pharmacology, Uppsala University, SE-751 24, Uppsala, Sweden
    Eur J Med Chem 36:137-46. 2001
    ..The data indicate that the His residue of the small rigid cyclic MSH core peptides does not participate in binding with the melanocortin receptors...
  26. ncbi The gamma(2)-MSH peptide mediates a central analgesic effect via a GABA-ergic mechanism that is independent from activation of melanocortin receptors
    V Klusa
    1Department of Pharmacology, Faculty of Medicine, University of Latvia, Riga, Latvia
    Neuropeptides 35:50-7. 2001
    ..Moreover, the mechanism for gamma(2)-MSH's analgesic effect appears to be distinct from that causing moderate catalepsia by gamma-MSH's...
  27. ncbi Antagonist and agonist activities of the mouse agouti protein fragment (91-131) at the melanocortin-1 receptor
    A N Eberle
    Laboratory of Endocrinology, Department of Research, University Hospital and University Children s Hospital, CH 4031 Basel, Switzerland
    J Recept Signal Transduct Res 21:25-45. 2001
    ....
  28. ncbi Interaction of melanin-concentrating hormone (MCH), neuropeptide E-I (NEI), neuropeptide G-E (NGE), and alpha-MSH with melanocortin and MCH receptors on mouse B16 melanoma cells
    E Hintermann
    Laboratory of Endocrinology, Department of Research (ZLF, University Hospital and University Children's Hospital, CH-4031 Basel, Switzerland
    J Recept Signal Transduct Res 21:93-116. 2001
    ..This shows that mammalian MCH-precursor-derived peptides may mimic MSH signalling via MC1-R activation at relatively high, but physiologically still relevant concentrations, as e.g. found in autocrine/paracrine signalling mechanisms...
  29. ncbi Thr40 and Met122 are new partial loss-of-function natural mutations of the human melanocortin 1 receptor
    C Jimenez-Cervantes
    Department of Biochemistry and Molecular Biology, School of Medicine, University of Murcia, Apto 4021, 30100 Espinardo, Murcia, Spain
    FEBS Lett 508:44-8. 2001
    ..The Val122Met form failed to achieve maximal cAMP responses comparable to the wild-type or Ile40Thr receptors. Thus, the Ile40Thr and Val122Met variants are partial loss-of-function natural mutations of MC1R...
  30. ncbi Melanocortin receptor agonist transiently increases oxygen consumption in rats
    L Jonsson
    Department of Physiology, University of Iceland, Reykjavik
    Neuroreport 12:3703-8. 2001
    ..This is the first study that describes long term effects of MC receptor agonist and antagonist on metabolism and energy balance...
  31. ncbi Homologous regulation of melanocortin-1 receptor (MC1R) expression in melanoma tumor cells in vivo
    Sylvie Froidevaux
    Laboratory of Endocrinology, Department of Research, University Hospital and University Children s Hospital, CH 4031 Basel, Switzerland
    J Recept Signal Transduct Res 22:111-21. 2002
    ..These results demonstrate the importance of in vivo receptor regulation studies, in particular in view of the potential use of MC1R as a target for melanoma therapy...
  32. ncbi Use of fluorescence polarization detection for the measurement of fluopeptidetm binding to G protein-coupled receptors
    A Gagne
    PerkinElmer Life Sciences, 549 Albany Street, Boston, MA 02118, USA
    J Recept Signal Transduct Res 22:333-43. 2002
    ..We have compared the assays across the different fluorescence polarization (FP) readers available to determine the parameters for each instrument necessary to achieve the required precision...
  33. ncbi Melanocortin system and eating disorders
    Roger A H Adan
    Rudolf Magnus Institute of Neuroscience, Department of Pharmacology and Anatomy, University Medical Centre Utrecht, Utrecht, The Netherlands
    Ann N Y Acad Sci 994:267-74. 2003
    ..Furthermore, we found a polymorphism, Ala67Thr AgRP, that was observed more frequently in anorexia nervosa...
  34. ncbi Melanocortin signaling and anorexia in chronic disease states
    Brent E Wisse
    Division of Metabolism, Endocrinology and Nutrition, Harborview Medical Center, University of Washington, Seattle, Washington 98104, USA
    Ann N Y Acad Sci 994:275-81. 2003
    ..The data presented in this paper summarize findings that implicate neuronal melanocortin signaling in inflammatory anorexia...
  35. ncbi Sequence characterization of teleost fish melanocortin receptors
    Darren W Logan
    MRC Human Genetics Unit, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, United Kingdom
    Ann N Y Acad Sci 994:319-30. 2003
    ..We have confirmed the sequences of these 10 genes and show the comparison of the amino acid sequences of the encoded proteins with the orthologous receptor in other vertebrates...
  36. ncbi Tumor necrosis factor alpha increases and alpha-melanocyte-stimulating hormone reduces uveal melanoma invasion through fibronectin
    Irene Canton
    Section of Human Metabolism, Division of Clinical Sciences North, Northern General Hospital, Sheffield S5 7AU, UK
    J Invest Dermatol 121:557-63. 2003
    ..Thus, ocular microenvironments that differ in their immunosuppressive/anti-inflammatory properties may influence the invasiveness of developing tumors...
  37. ncbi Genetic association and cellular function of MC1R variant alleles in human pigmentation
    R A Sturm
    Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland 4072, Australia
    Ann N Y Acad Sci 994:348-58. 2003
    ..With this objective, we have established more than 300 melanocyte cell strains of defined MC1R genotype...
  38. ncbi Significance of the melanocortin 1 receptor in regulating human melanocyte pigmentation, proliferation, and survival
    Ana Luisa Kadekaro
    Department of Dermatology, University of Cincinnati, Cincinnati, Ohio 45267, USA
    Ann N Y Acad Sci 994:359-65. 2003
    ..This effect was absent in human melanocytes with loss of function MC1R mutations. We predict that the survival effect of alpha-MSH is caused by reduction of UV-induced DNA damage and contributes to the prevention of melanoma...
  39. ncbi Avian melanocortin system: alpha-MSH may act as an autocrine/paracrine hormone: a minireview
    Sakae Takeuchi
    Department of Biology, Faculty of Science, Okayama University, Okayama 700 8530, Japan
    Ann N Y Acad Sci 994:366-72. 2003
    ..Collectively, the data reviewed here indicate that alpha-MSH is produced locally and acts as an autocrine/paracrine hormone in birds...
  40. ncbi Biological and conformational study of beta-substituted prolines in MT-II template: steric effects leading to human MC5 receptor selectivity
    M Cai
    Department of Chemistry, University of Arizona, Tucson, AZ 85721, USA
    J Pept Res 63:116-31. 2004
    ....
  41. ncbi Melanocortinergic modulation of cholecystokinin-induced suppression of feeding through extracellular signal-regulated kinase signaling in rat solitary nucleus
    Gregory M Sutton
    Neurobiology of Nutrition Laboratory, Pennington Biomedical Research Center, Louisiana State University, 6400 Perkins Road, Baton Rouge, Louisiana 70808, USA
    Endocrinology 146:3739-47. 2005
    ..The cAMP-->ERK-->CREB cascade may thus constitute a molecular integrator for converging satiety signals from the gut and adiposity signals from the hypothalamus in the control of meal size and food intake...
  42. pmc Further structure-activity studies of lactam derivatives of MT-II and SHU-9119: their activity and selectivity at human melanocortin receptors 3, 4, and 5
    Paolo Grieco
    Department of Chemistry, University of Arizona, Tucson, AZ 85721, USA
    Peptides 28:1191-6. 2007
    ..PG-106 will be useful in further efforts to differentiate the substructural features responsible for selectivity at the hMC3R, hMC4R, and hMC5R...
  43. ncbi The central melanocortin system and fever
    Jeffrey B Tatro
    Department of Medicine and the Tupper Research Institute, Tufts University School of Medicine and Tufts New England Medical Center, Boston, Massachusetts 02111, USA
    Ann N Y Acad Sci 994:246-57. 2003
    ....
  44. ncbi New insights into the functions of alpha-MSH and related peptides in the immune system
    Thomas A Luger
    Department of Dermatology and Ludwig Boltzmann Institute for Cell Biology and Immunobiology of the Skin, University of Munster, 48149 Munster, Germany
    Ann N Y Acad Sci 994:133-40. 2003
    ..Therefore, therapeutic application of alpha-MSH or related peptides (KPVs) as well as alpha-MSH/KPV-pulsed DCs may be a useful approach for the treatment of inflammatory, autoimmune, and allergic diseases in the future...
  45. ncbi Obesity drug pipeline not so fat
    Trisha Gura
    Science 299:849-52. 2003
  46. ncbi Having it all
    Trisha Gura
    Science 299:850. 2003
  47. ncbi The potent melanocortin receptor agonist melanotan-II promotes peripheral nerve regeneration and has neuroprotective properties in the rat
    Mariël P ter Laak
    Department of Medical Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG, Utrecht, The Netherlands
    Eur J Pharmacol 462:179-83. 2003
    ..Thus, the present data for the first time demonstrate the effectiveness of the potent alpha-MSH analog melanotan-II in nerve regeneration and neuroprotection...
  48. ncbi Differential sensitivity to central leptin and insulin in male and female rats
    Deborah J Clegg
    Department of Psychiatry, University of Cincinnati Medical Center, Cincinnati, OH 45267 0559, USA
    Diabetes 52:682-7. 2003
    ..Because insulin and leptin reflect different fat beds and are differentially distributed in the male and female sexes, the implication is that the male and female sexes regulate adiposity-relevant parameters differently...
  49. ncbi Association of feather colour with constitutively active melanocortin 1 receptors in chicken
    Maria K Ling
    Department of Neuroscience, Uppsala University, Uppsala, Sweden
    Eur J Biochem 270:1441-9. 2003
    ....
  50. ncbi Ac-Nle-c[Asp-His-DPhe-Arg-Trp-Lys]-NH2 induces penile erection via brain and spinal melanocortin receptors
    H Wessells
    Department of Urology, University of Washington School of Medicine, Harborview Medical Center, 325 Ninth Avenue, Seattle, WA 98195, USA
    Neuroscience 118:755-62. 2003
    ..These results provide new insight into the central melanocortinergic pathways that mediate penile erection and may allow for more efficacious melanotropin-based therapy for erectile dysfunction...
  51. ncbi Design, synthesis, and biological evaluation of non-peptidic ligands at the Xenopus laevis skin-melanocortin receptor
    Ursula Tammler
    Pharmaceutical Institute, University of Bonn, An der Immenburg 4, 53121 Bonn, Germany
    Eur J Med Chem 38:481-93. 2003
    ..The specificity for MC receptors was tested at various G-protein coupled receptors. In conclusion, the synthesis of non-peptidic MC receptor antagonists is described which may serve as lead compounds for further studies...
  52. ncbi Melanocortin tetrapeptides modified at the N-terminus, His, Phe, Arg, and Trp positions
    Jerry Ryan Holder
    University of Florida, Department of Medicinal Chemistry, Gainesville, Florida 32610, USA
    Ann N Y Acad Sci 994:36-48. 2003
    ....
  53. ncbi alpha-MSH and desacetyl-alpha-MSH signaling through melanocortin receptors
    Kathleen G Mountjoy
    Departments of Physiology, Faculty of Medical and Health Sciences, University of Auckland, Auckland 1, New Zealand
    Ann N Y Acad Sci 994:58-65. 2003
    ....
  54. ncbi Syndecan-3 modulates food intake by interacting with the melanocortin/AgRP pathway
    Ofer Reizes
    Procter Gamble Pharmaceuticals, Inc, Health Care Research Center, Mason, Ohio 45040, USA
    Ann N Y Acad Sci 994:66-73. 2003
    ..Collectively, the data suggest that the modulation of melanocortin regulation of energy balance by syndecan-3 is modulated by the action of a TIMP-3-sensitive metalloprotease...
  55. ncbi [Detection of binding activity and biologic effect of a novel alpha-melanocyte-stimulating hormone analogue]
    Ying Ying
    Department of Laboratory Examination, Fuzhou General Hospital, Nanjing Military Command, Fuzhou 350025, China
    Yao Xue Xue Bao 42:269-73. 2007
    ..Its EC50 values for MC1, MC3, MC4, and MC5 receptors were (0.45 +/- 0.07), (7.80 +/- 0.65), (2.55 +/- 0.23) and (0.33 +/- 0.09) nmol L(-1), respectively. In these tests, the novel alpha-MSH analogue is a MC1R and MC5R selective agonist...
  56. ncbi The melanocortin-1 receptor and human pigmentation
    Z Abdel-Malek
    Department of Dermatology, University of Cincinnati, Ohio 45267, USA
    Ann N Y Acad Sci 885:117-33. 1999
    ....
  57. ncbi Three-dimensional molecular models of the hMC1R melanocortin receptor: complexes with melanotropin peptide agonists
    C Haskell-Luevano
    Department of Chemistry, University of Arizona, Tucson 85721, USA
    Drug Des Discov 14:197-211. 1996
    ..Finally, limited MC1R mutagenesis studies comparing alpha-MSH and NDP-MSH are interpreted within the context of the proposed hMC1R models...
  58. ncbi Characterization of Agouti-related protein binding to melanocortin receptors
    Y K Yang
    Department of Surgery, University of Michigan Medical Center, Ann Arbor 48109 0682, USA
    Mol Endocrinol 13:148-55. 1999
    ..Because [Nle4, D-Phe7] (NDP)-MSH displaces the binding of [125I]AGRP(87-132) to MCRs and AGRP(87-132) displaces the binding of [125I]NDP-MSH, we conclude that these molecules bind in a competitive fashion to melanocortin receptors...
  59. ncbi Obesity sheds its secrets
    T Gura
    Science 275:751-3. 1997
  60. ncbi Involvement of mi-transcription factor in expression of alpha-melanocyte-stimulating hormone receptor in cultured mast cells of mice
    S Adachi
    Department of Pathology, Osaka University Medical School, Suita, Japan
    J Immunol 164:855-60. 2000
    ..We found +-MITF bound two of five CANNTG motifs, and both motifs were essential for the transactivation of the MC1R gene by +-MITF. These results indicated that +-MITF directly transactivated the MC1R gene through these two motifs...
  61. ncbi Amino acid residues in third intracellular loop of melanocortin 1 receptor are involved in G-protein coupling
    P A Frändberg
    Division of Biological Research on Drug Dependence, Biomedical Centre, Uppsala, Sweden
    Biochem Mol Biol Int 46:913-22. 1998
    ....
  62. pmc Genetic studies of the mouse mutations mahogany and mahoganoid
    K A Miller
    Department of Pediatrics, Stanford University School of Medicine, California 94305 5428, USA
    Genetics 146:1407-15. 1997
    ..Plasma levels of alpha-MSH and of ACTH were unaffected by md or mg. These results suggest that md and mg interfere directly with Agouti signaling, possibly at the level of protein production or receptor regulation...
  63. ncbi Melanocortin receptor binding determinants in the agouti protein
    L L Kiefer
    Division of Biochemistry, Glaxo Wellcome Inc, Research Triangle Park, North Carolina 27709, USA
    Biochemistry 37:991-7. 1998
    ..These agouti variants with altered receptor selectivity may be useful in determining the role of melanocortin receptors in diabetes and obesity...
  64. pmc Interaction of Agouti protein with the melanocortin 1 receptor in vitro and in vivo
    M M Ollmann
    Department of Pediatrics, and the Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, California 94305 5428, USA
    Genes Dev 12:316-30. 1998
    ....
  65. ncbi The melanocortin system in Fugu: determination of POMC/AGRP/MCR gene repertoire and synteny, as well as pharmacology and anatomical distribution of the MCRs
    Janis Klovins
    Department of Neuroscience, Uppsala University, Uppsala, Sweden
    Mol Biol Evol 21:563-79. 2004
    ....
  66. ncbi Receptor biology of the melanocortins, a family of neuroimmunomodulatory peptides
    J B Tatro
    Division of Endocrinology, Diabetes, Metabolism and Molecular Medicine, New England Medical Center Hospitals, Boston, Mass, USA
    Neuroimmunomodulation 3:259-84. 1996
    ....
  67. ncbi Biphasic developmental expression of adrenocorticotropin receptor messenger ribonucleic acid levels in the baboon fetal adrenal gland
    E D Albrecht
    Department of Obstetrics Gynecology, Center for Studies in Reproduction, University of Maryland School of Medicine, Baltimore, 21201, USA
    Endocrinology 137:1292-8. 1996
    ..g. dehydroepiandrosterone, biosynthesis within the baboon fetal adrenal gland...
  68. ncbi Human adrenal corticocarcinoma NCI-H295R cells produce more androgens than NCI-H295A cells and differ in 3beta-hydroxysteroid dehydrogenase type 2 and 17,20 lyase activities
    Elika Samandari
    Pediatric Endocrinology and Diabetology, University Children s Hospital Bern, Freiburgstrasse 15, G3 812, 3010 Bern, Switzerland
    J Endocrinol 195:459-72. 2007
    ..Our data suggest that comparative studies between NCI-H295A and NCI-H295R cells may help find important regulators of mineralocorticoid or androgen biosynthesis...
  69. ncbi ACTH stimulates insulin secretion from MIN6 cells and primary mouse and human islets of Langerhans
    H T Al-Majed
    Centre for Reproduction, Endocrinology and Diabetes, GKT School of Biomedical Sciences, King s College London, Guy s Campus, London SE1 1UL, UK
    J Endocrinol 180:155-66. 2004
    ..Overall the results demonstrate that the MC2-R is expressed in beta-cells and suggest that activation of the receptor by ACTH initiates insulin secretion through the activation of PKA in association with Ca2+ influx into beta-cells...
  70. ncbi Characterization of melanocortin receptor subtype expression in murine adipose tissues and in the 3T3-L1 cell line
    B A Boston
    Department of Pediatrics, Oregon Health Sciences University, Portland 97201, USA
    Endocrinology 137:2043-50. 1996
    ..Although the agouti signaling peptide is a potent antagonist of NDP-MSH binding to the MC1 and MC4 melanocortin receptors, agouti was unable to block NDP-MSH binding in the 3T3-L1 adipocyte...
  71. ncbi Luteinizing hormone (LH)-responsive Cushing's syndrome: the demonstration of LH receptor messenger ribonucleic acid in hyperplastic adrenal cells, which respond to chorionic gonadotropin and serotonin agonists in vitro
    Richard A Feelders
    Department of Internal Medicine, Erasmus University Medical Center Rotterdam, 3015 GD Rotterdam, The Netherlands
    J Clin Endocrinol Metab 88:230-7. 2003
    ..Despite the regulatory potential of LH and 5-HT4 receptor agonists on cortisol production in our patients, their adrenals seemed to be still sensitive to ACTH, both in vivo and in vitro...
  72. ncbi Melanocortin receptor type 2 (MC2R, ACTH receptor) expression in patients with alopecia areata
    Hong Wei Guo
    Department of Dermatology, Southwest hospital affiliated to The Third Military Medical University, Chongqing, China
    Exp Dermatol 19:1020-2. 2010
    ..These findings demonstrate that MC2R expression is aberrant in AA and suggest a deficit in ACTH/MC2R activity may play an important role in the pathophysiology of AA...
  73. ncbi Mutations in adrenocortical tumors
    M Reincke
    Medical Department II, University of Freiburg, Germany
    Horm Metab Res 30:447-55. 1998
    ..This indicates that the signaling pathways responsible for adrenocortical tumor formation are different from that of other endocrine neoplasms like pituitary and thyroid adenomas...
  74. ncbi Allosteric antagonist binding sites in class B GPCRs: corticotropin receptor 1
    Supriyo Bhattacharya
    Department of Immunology, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA
    J Comput Aided Mol Des 24:659-74. 2010
    ..Thus, the conformational changes induced by NBI-27914 improved the ligand screening efficiency of the CRF(1)-R model and demonstrate a generalized application of the method in drug discovery...
  75. ncbi Targeted ablation of pituitary pre-proopiomelanocortin cells by herpes simplex virus-1 thymidine kinase differentially regulates mRNAs encoding the adrenocorticotropin receptor and aldosterone synthase in the mouse adrenal gland
    R G Allen
    Center for Research on Occupational and Environmental Toxicology, Vollum Institute, Oregon Health Sciences University, Portland 97201, USA
    Mol Endocrinol 9:1005-16. 1995
    ....
  76. ncbi Isolated glucocorticoid deficiency and ACTH receptor mutations
    C Tsigos
    Hellenic National Center for the Research, Prevention and Treatment of Diabetes Mellitus and Its Complications, Athens, Greece
    Arch Med Res 30:475-80. 1999
    ....
  77. ncbi Expression and spatio-temporal distribution of differentiation and proliferation markers during mouse adrenal development
    Dominik M Schulte
    Division of Endocrinology and Metabolism, Department of Internal Medicine II, Klinikum der Albert Ludwigs Universität, Freiburg, Germany
    Gene Expr Patterns 7:72-81. 2007
    ..Taken together, these findings are in accordance with the concept of distinct cell populations present during adrenocortical development with a highly proliferative phenotype or differentiated steroidogenic properties...
  78. ncbi Mapping of the ACTH, MSH, and neural (MC3 and MC4) melanocortin receptors in the mouse and human
    R E Magenis
    Department of Molecular and Medical Genetics, Oregon Health Sciences University, Portland 97201
    Mamm Genome 5:503-8. 1994
    ..The data reported here also show that the neural MC3 receptor maps close to a disease locus for benign neonatal epilepsy in human and near the E1-2 epilepsy susceptibility locus in the mouse...
  79. ncbi Expressional regulation of the angiopoietin-1 and -2 and the endothelial-specific receptor tyrosine kinase Tie2 in adrenal atrophy: a study of adrenocorticotropin-induced repair
    Olivier Feraud
    Equipe Mixte Institut National de la Santé et de la Recherche Médicale, EMI 02 19, Laboratoire de Développement et Vieillissement de l Endothélium, 38054 Grenoble Cedex 9, France
    Endocrinology 144:4607-15. 2003
    ..These results reinforce the role of ACTH in the regulation of angiogenic factors in adrenal gland and suggest that the Ang/Tie2 system might represent a key player for stabilization of adrenal endothelium...
  80. ncbi Expression of the ACTH receptor, steroidogenic acute regulatory protein, and steroidogenic enzymes in canine cortisol-secreting adrenocortical tumors
    S Galac
    Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands
    Domest Anim Endocrinol 39:259-67. 2010
    ..In conclusion, RT-PCR analysis revealed no overexpression of StAR and steroidogenic enzymes in canine cortisol-secreting ATs. Significant downregulation of ACTH-R in carcinomas might be associated with the malignant character of the AT...
  81. ncbi The mouse adrenocorticotropin receptor gene: cloning and characterization of its promoter and evidence for a role for the orphan nuclear receptor steroidogenic factor 1
    F M Cammas
    Department of Chemical Endocrinology, St Bartholomew s and the Royal London School of Medicine and Dentistry, United Kingdom
    Mol Endocrinol 11:867-76. 1997
    ..The other as yet unknown factor binding between position -1236 bp and -908 bp acts as a strong inhibitory factor in nonadrenal steroidogenic cells, resulting in the adrenal-specific expression of ACTH-R...
  82. ncbi Antagonism of CRF receptors prevents the deficit in brain reward function associated with precipitated nicotine withdrawal in rats
    Adrie W Bruijnzeel
    Department of Psychiatry, McKnight Brain Institute, University of Florida, Gainesville, FL 32610, USA
    Neuropsychopharmacology 32:955-63. 2007
    ..These data provide support for the hypothesis that a hyperactivity of brain CRF systems may at least partly mediate the initiation of the negative affective aspects of nicotine withdrawal...
  83. ncbi Unilateral testicular tumour associated to congenital adrenal hyperplasia: Failure of specific tumoral molecular markers to discriminate between adrenal rest and leydigioma
    P Fenichel
    Service d endocrinologie et médecine de la reproduction, Hopital de l Archet, CHU de Nice, BP 3079, 06202 Nice cedex 03, France
    Ann Endocrinol (Paris) 69:453-8. 2008
    ..However, lack of tumoral LH-R mRNA expression and a tumour-free 3-year follow-up led us to retain the diagnosis of adrenal rest tumour with loss of adrenal gene expression and progressive autonomous behaviour...
  84. ncbi Age-specific changes in sex steroid biosynthesis and sex development
    Nils Krone
    Division of Medical Sciences, Institute of Biomedical Research, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    Best Pract Res Clin Endocrinol Metab 21:393-401. 2007
    ....
  85. ncbi Cushing's syndrome due to a gastric inhibitory polypeptide-dependent adrenal adenoma: insights into hormonal control of adrenocortical tumorigenesis
    O Chabre
    Services d Endocrinologie, Centre Hospitalier Universitaire, Grenoble, France olivier
    J Clin Endocrinol Metab 83:3134-43. 1998
    ....
  86. ncbi Adrenocorticotropin receptor and adrenal disorders
    B Allolio
    Schwerpunkt Endokrinologie, Medizinische Universitatsklinik, Wurzburg, Deutschland
    Horm Res 47:273-8. 1997
    ..No correlation between ACTH receptor mRNA expression and circulating ACTH levels has been found in patients with adrenal disorders casting doubts on the physiological significance of ACTH receptor upregulation by its own ligand in vivo...
  87. ncbi Developmental programming of adult adrenal structure and steroidogenesis: effects of fetal glucocorticoid excess and postnatal dietary omega-3 fatty acids
    Brendan J Waddell
    School of Anatomy and Human Biology, The University of Western Australia, 35 Stirling Highway, Crawley, Perth, Western Australia 6009, Australia
    J Endocrinol 205:171-8. 2010
    ..In conclusion, this study shows that prenatal exposure to dexamethasone does not increase basal adrenocortical activity but does result in a more stress-responsive adrenal phenotype, possibly via increased Mc2r expression...
  88. ncbi Identification of domains responsible for specific membrane transport and ligand specificity of the ACTH receptor (MC2R)
    Davids Fridmanis
    Latvian Biomedical Research and Study Centre, Riga, Latvia
    Mol Cell Endocrinol 321:175-83. 2010
    ..We discuss the mechanisms involved in bypassing these arrest signals via an interaction with melanocortin 2 receptor accessory protein (MRAP) and the possible mechanisms that determine the high ligand-binding specificity of ACTHR...
  89. ncbi ACTH-receptor deficient mutants of the Y1 mouse adrenocortical tumor cell line
    B P Schimmer
    Banting and Best Department of Medical Research, University of Toronto, Ontario, Canada
    Endocr Res 21:139-56. 1995
    ..These results suggest that the adenylyl cyclase system in the mutants is otherwise intact and that the failure to express ACTH receptor transcripts limits the responsiveness of these clones to the hormone...
  90. ncbi Prevalence of melanocortin system transcripts in rat salt homeostasis endocrine tissues
    S J Wachira
    Department of Biology, Morgan State University, Baltimore, Maryland 21251, USA
    Cell Mol Biol (Noisy-le-grand) 53:8-14. 2007
    ..These results are therefore inconsistent with an endocrine pathway that involves pituitary derived gamma-MSH modulating adrenal function in response to high dietary salt intake...
  91. ncbi ACTH receptor (MC2R) promoter variants associated with infantile spasms modulate MC2R expression and responsiveness to ACTH
    Ying Xue Ding
    Department of Pediatrics, Chinese PLA General Hospital, Ministry of Health, Beijing, PR China
    Pharmacogenet Genomics 20:71-6. 2010
    ..In this study, we further elucidated functional significances of the TCCT haplotype...
  92. ncbi Human melanocortin receptor 2 expression and functionality: effects of protein kinase A and protein kinase C on desensitization and internalization
    Zuzana Kilianova
    Service d endocrinologie, Departement de Medecine, Faculte de Medecine et des Sciences de la Sante, Universite de Sherbrooke, Quebec, Canada
    Endocrinology 147:2325-37. 2006
    ....
  93. ncbi Differential regulation of the human adrenocorticotropin receptor [melanocortin-2 receptor (MC2R)] by human MC2R accessory protein isoforms alpha and beta in isogenic human embryonic kidney 293 cells
    Simon Roy
    Service d endocrinologie, Departement de Medecine, Faculte de Medecine et des Sciences de la Sante, Universite de Sherbrooke, Sherbrooke, Quebec, Canada J1H 5N4
    Mol Endocrinol 21:1656-69. 2007
    ....
  94. pmc Severe loss-of-function mutations in the adrenocorticotropin receptor (ACTHR, MC2R) can be found in patients diagnosed with salt-losing adrenal hypoplasia
    Lin Lin
    UCL Institute of Child Health and Department of Medicine, University College London, London, UK
    Clin Endocrinol (Oxf) 66:205-10. 2007
    ....
  95. ncbi ACTH 1-24 inhibits proliferation of adrenocortical tumors in vivo
    Oliver Zwermann
    Medizinische Klinik Innenstadt, Ludwig Maximilians University, Munich, Germany
    Eur J Endocrinol 153:435-44. 2005
    ..In vivo, potential effects of endogenous ACTH on adrenal tumori-genesis can not be separated from effects of other POMC derived peptides...
  96. pmc Functional consequence of a novel Y129C mutation in a patient with two contradictory melanocortin-2-receptor mutations
    Li F Chan
    Queen Mary University of London, Centre for Endocrinology, Barts and the London School of Medicine and Dentistry, London, UK
    Eur J Endocrinol 160:705-10. 2009
    ..Inactivating mutations in the ACTH receptor (melanocortin-2-receptor, MC2R) are well described and account for approximately 25% of cases. By contrast, activating MC2R mutations are extremely rare...
  97. ncbi Cushing's syndrome secondary to adrenocorticotropin-independent macronodular adrenocortical hyperplasia due to activating mutations of GNAS1 gene
    Maria Candida Barisson Villares Fragoso
    Unidade de Endocrinologia do Desenvolvimento, Laboratorio de Hormonios e Genetica Molecular LIM 42, Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, Brazil 01060 970
    J Clin Endocrinol Metab 88:2147-51. 2003
    ....
  98. ncbi Virilizing adrenocortical adenoma: in vitro steroidogenesis, immunohistochemical studies of steroidogenic enzymes, and gene expression of corticotropin receptor
    T Imai
    Department of Surgery II, Nagoya University School of Medicine, Japan
    Surgery 125:396-402. 1999
    ..CONCLUSIONS: The lack of response to ACTH is the result of a deficiency of ACTH receptor expression in the virilizing tumor cells. Androgens were autonomously produced in adrenal adenoma cells without ACTH regulation...
  99. ncbi Administration of ACTH to restrained, pregnant sows alters their pigs' hypothalamic-pituitary-adrenal (HPA) axis
    M F Haussmann
    Iowa State University, Ames 50011 3150, USA
    J Anim Sci 78:2399-411. 2000
    ..006) than ACTH pigs. Thus, exogenous ACTH and restraint during gestation alters the HPA axis of the sow's offspring, and during stressful situations later in life health, and therefore welfare, may be compromised...
  100. ncbi Interaction of the melanocortin 2 receptor with nucleoporin 50: evidence for a novel pathway between a G-protein-coupled receptor and the nucleus
    Marina Doufexis
    Centre for Endocrinology, William Harvey Research Institute, Barts and The London, Queen Mary, University of London, West Smithfield, London EC1A 7BE, UK
    FASEB J 21:4095-100. 2007
    ..This time course is most consistent with MC2R internalization dynamics and may suggest a novel role for Nup50...
  101. ncbi A novel adrenocorticotropin receptor mutation alters its structure and function, causing familial glucocorticoid deficiency
    Rocío A Artigas
    Departamento de Endocrinologia, Facultad de Medicina, Pontificia Universidad Catolica de Chile, Lira 85, 5 degrees piso, 8330074 Santiago, Chile
    J Clin Endocrinol Metab 93:3097-105. 2008
    ..Familial glucocorticoid deficiency (FGD) is an autosomal recessive disorder characterized by unresponsiveness to ACTH. In this study, two mutations of the ACTH receptor (MC2R) gene are reported in this FGD clinical case...

Research Grants45

  1. Primate Fetal Adrenal Development: Impact on Physiological Processes After Birth
    Eugene D Albrecht; Fiscal Year: 2013
    ....
  2. AVIDIN-BIOTIN TECHNOLOGY FOR HORMONE RECEPTOR ISOLATION
    Klaus Hofmann; Fiscal Year: 1990
    ..Noteworthy is the fact that we have been successful in solubilizing the AII receptor with retention of binding affinity for I251-labeled biotinylated AII probes...
  3. IDENTIFICATION OF GENE FOR ACTH-RECEPTOR BY CLONING
    JANAKIRAMAN RAMACHANDRAN; Fiscal Year: 1990
    ..Potent antagonists will be developed using cell lines over expressing ACTH- receptor gene...
  4. MORPHINE: CNS SITES OF ANALGESIA AND ADDICTION
    YASUKO JACQUET; Fiscal Year: 1980
    ....
  5. Human Melanocortin-4 Receptor Polymorphisms
    Carrie Haskell Luevano; Fiscal Year: 2007
    ..Understanding obesity related mechanisms may ultimately result in therapeutic agents to prevent or treat the diseases associated with over eating. ..
  6. STRUCTURAL DETERMINANTS OF NEUROENDOCRINE RECEPTORS
    Carrie Haskell Luevano; Fiscal Year: 2008
    ..abstract_text> ..
  7. 19th International Pigment Cell Conference - 2005
    Zalfa Abdel Malek; Fiscal Year: 2005
    ..abstract_text> ..
  8. Peptide Hormone Structure Function
    Victor J Hruby; Fiscal Year: 2010
    ....
  9. Molecular determinants of ACTH receptor for ligand binding
    Yingkui Yang; Fiscal Year: 2006
    ..The information will serve to establish a foundation on which to build a comprehensive understanding of the signaling events that regulate ACTH mediated adrenal function in physiologic and diseased states. ..
  10. Melanocortin-3 receptor regulation of insulin action
    Andrew Butler; Fiscal Year: 2005
    ..The results of these experiments will provide the first definitive evidence that manipulation of the MC3R might be a viable approach for treating insulin resistance. ..
  11. Genomic & Genetic Characterization of Amplicons in GBMs
    Lynda Chin; Fiscal Year: 2007
    ..The highest potential candidate glioma oncogene will be further validated by rigorous in vivo transgenesis study. ..
  12. UNDERGRADUATE STUDENT TRAINING IN ACADEMIC RESEARCH
    Benjamin Clarke; Fiscal Year: 2007
    ..Academic advisement is structured on three tiers: round table discussions, faculty consultations, and intervention through the AILRC. ..
  13. Mentored Clinical Research Scholar Program at Iowa
    ALLYN MARK; Fiscal Year: 2007
    ..These and other University research programs extend into the community--statewide and beyond--and include numerous disease registers and a broad network of collaborating institutions. [unreadable] [unreadable] [unreadable]..
  14. Syndecan & CNS Melanocortin Signaling in Energy Balance
    Stephen Benoit; Fiscal Year: 2007
    ..The results may provide important, basic insights into the control of body weight by the central melanocortin system and its recently identified co-receptor, syndecan-3. ..
  15. Role of CRF in the affective symptoms of acute and protracted ethanol withdrawal
    ADRIAAN BRUIJNZEEL; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  16. Attractin and Mahoganoid in Spongy Neurodegeneration
    Gregory Barsh; Fiscal Year: 2007
    ..Investigating the biochemical, cellular, and genetic relationships between Atrn, Mahoganoid, and PrP is likely to provide general insight into the pathogenesis of spongy degeneration. [unreadable] [unreadable]..
  17. Fifth International Melanocortin Meeting
    ROGER CONE; Fiscal Year: 2002
    ..To facilitate the gathering of a large international audience, funds are specifically requested to cover travel expenses for 17 speakers. ..
  18. Glucose-dependent Insulinotropic Peptide & Bone Turnover
    Carlos Isales; Fiscal Year: 2006
    ..This in turn may signal GIP as a potential hormone target for pharmacologic intervention in bone pathologies such as osteoporosis. [unreadable] [unreadable]..
  19. Role of Pro-opiomelanocortin mutations in human obesity
    Christian Vaisse; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  20. Altering Lymphocyte Trafficking Patterns Using Dexamethasone
    Benjamin Clarke; Fiscal Year: 2008
    ..This study will determine if glucocorticoids do alter in vivo T cell function. [unreadable] [unreadable] [unreadable]..
  21. VASCULAR EFFECTS OF HOMOCYSTEINE IN HUMANS
    WILLIAM HAYNES; Fiscal Year: 2005
    ..The results may also suggest novel potential therapeutic approaches to be tested in future outcome trials. ..
  22. Leptin resistance: 1 mechanism underlying age-related obesity
    PHILIP SCARPACE; Fiscal Year: 2008
    ..Such discoveries may lead to new treatments for obesity and the diabetes associated with obesity. ..
  23. Glucocorticoids and Programming of the Hypertensive Vascular Phenotype
    Omid Khorram; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  24. The Melanocortin-4 Receptor in Human Obesity
    Christian Vaisse; Fiscal Year: 2010
    ..These experiments could lead to new strategies to pharmacologically target MC4R for the treatment of obesity. ..
  25. IDENTIFYING NIDDM GENES USING ADMIXED POPULATIONS
    Mark Shriver; Fiscal Year: 2001
    ..They will verify any positive associations found using sib-pair linkage analysis and the transmission disequilibrium test. ..
  26. BRIDGES TO THE DOCTORATE
    George Trachte; Fiscal Year: 2006
    ..These students will be [unreadable] established in the principals of investigative work, the scientific method, and appreciate the [unreadable] importance of research in minority health disparities. [unreadable] [unreadable]..
  27. Genetics of Dark Skin in Mice
    Gregory Barsh; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  28. Human Endometrial Nitric Oxide: Regulation and Function
    Omid Khorram; Fiscal Year: 2003
    ..This pilot study should shed light on regulation and function of human endometrial NO pathway, an uninvestigated area of research with profound clinical significance. ..
  29. Role of CNS Insulin in Learning and Memory
    Stephen Benoit; Fiscal Year: 2003
    ..Ultimately, this line of investigation may offer novel therapeutic strategies for treating individuals with cognitive disorders such as Alzheimer' s disease. ..
  30. REGULATION OF ENERGY BALANCE BY MELANOCORTIN ANTAGONISTS
    Gregory Barsh; Fiscal Year: 2003
    ..abstract_text> ..
  31. HYPOTHALAMIC CONTROL OF FEEDING AND METABOLISM
    ROGER CONE; Fiscal Year: 2003
    ..Finally, the specific hypothesis that altered levels of POMC gene expression may be a risk factor for obesity will be directly tested by Dr. Boston and his collaborators (project II). ..
  32. ROLES OF ENDOGENOUS ALPHA MSH IN FEVER AND IMMUNITY
    JEFFREY TATRO; Fiscal Year: 2003
    ..abstract_text> ..
  33. GENE THERAPY OF DIABETIC PENILE ENDOTHELIAL DYSFUNCTION
    Hunter Wessells; Fiscal Year: 2004
    ..Such a strategy may ultimately be beneficial to men with ED due to diabetes as well as smoking, hypercholesterolemia, and aging. ..
  34. Neural Melanocortin Signaling and Erectile Function
    Hunter Wessells; Fiscal Year: 2005
    ..The findings may allow us to develop receptor-specific therapeutic strategies, which may ultimately be beneficial to men and women with sexual dysfunction. ..
  35. Immortalized Human Cavernosal Endothelial Cells
    Hunter Wessells; Fiscal Year: 2005
    ..abstract_text> ..
  36. IMPAIRED LEPTIN RESPONSIVENESS WITH AGE
    PHILIP SCARPACE; Fiscal Year: 2002
    ..The potential for vitamin A supplementation to reverse the age-related increase in serum leptin and restore leptin responsiveness is addressed in this proposal. ..
  37. The Role of Central Melanocortins in Cachexia
    Daniel Marks; Fiscal Year: 2006
    ..Ultimately, this work may lead to investigation of drug therapy for this widespread medical problem. ..
  38. MOLECULAR PATHOGENESIS OF MALIGNANT MELANOMA
    Lynda Chin; Fiscal Year: 2002
    ....
  39. Age-related Obesity: Interventions with Gene Delivery
    PHILIP SCARPACE; Fiscal Year: 2006
    ..Such discoveries may lead to new treatments for obesity and the diabetes associated with obesity. ..
  40. Neuropeptide-based therapies for nicotine dependence
    ADRIAAN BRUIJNZEEL; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  41. CONSTRUCTION AND APPLICATION OF A US ADMIXTURE MAP
    Mark Shriver; Fiscal Year: 2006
    ..From simulation studies, we estimate that about 1000 AIMs will be required for genome-wide mapping with two-way admixture, and about 1500 for admixture between three populations. [unreadable] [unreadable] [unreadable]..
  42. Behavioral Mechanisms of CNS Melanocortin Action
    Stephen Benoit; Fiscal Year: 2007
    ..These results will expand our understanding of this critical system for the regulation of food intake and body weight and, hopefully, provide insight into important structures and systems that are downstream of the melanocortins. ..