nicotinic receptors

Summary

Summary: One of the two major classes of cholinergic receptors. Nicotinic receptors were originally distinguished by their preference for nicotine over muscarine. They are generally divided into muscle-type and neuronal-type (previously ganglionic) based on pharmacology, molecular biology, and biophysical properties of the channels.

Top Publications

  1. ncbi Nicotinic acetylcholine receptor alpha7 subunit is an essential regulator of inflammation
    Hong Wang
    Laboratory of Biomedical Science, North Shore Long Island Jewish Research Institute, 350 Community Drive, Manhasset, New York 11030, USA
    Nature 421:384-8. 2003
  2. pmc Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1
    Christopher I Amos
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Nat Genet 40:616-22. 2008
  3. ncbi A variant associated with nicotine dependence, lung cancer and peripheral arterial disease
    Thorgeir E Thorgeirsson
    deCODE Genetics, 101 Reykjavik, Iceland
    Nature 452:638-42. 2008
  4. ncbi A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25
    Rayjean J Hung
    International Agency for Research on Cancer IARC, Lyon 69008, France
    Nature 452:633-7. 2008
  5. pmc Mammalian nicotinic acetylcholine receptors: from structure to function
    Edson X Albuquerque
    Department of Pharmacology and Experimental Therapeutics, University of Maryland School of Medicine, Baltimore, MD, USA
    Physiol Rev 89:73-120. 2009
  6. ncbi Refined structure of the nicotinic acetylcholine receptor at 4A resolution
    Nigel Unwin
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    J Mol Biol 346:967-89. 2005
  7. pmc Variants in nicotinic receptors and risk for nicotine dependence
    Laura Jean Bierut
    Department of Psychiatry, Washington University School of Medicine, Box 8134, 660 South Euclid Ave, St Louis, MO 63110, USA
    Am J Psychiatry 165:1163-71. 2008
  8. pmc Cholinergic nicotinic receptor genes implicated in a nicotine dependence association study targeting 348 candidate genes with 3713 SNPs
    Scott F Saccone
    Department of Psychiatry, Box 8134, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Hum Mol Genet 16:36-49. 2007
  9. ncbi Nicotinic receptors: allosteric transitions and therapeutic targets in the nervous system
    Antoine Taly
    Laboratoire de Chimie Biophysique, Institut de Science et d Ingenierie Supramoleculaires, UMR 7006 CNRS Université de Strasbourg, 8 allee Gaspard Monge, 67000 Strasbourg, France
    Nat Rev Drug Discov 8:733-50. 2009
  10. ncbi Brain nicotinic acetylcholine receptors: native subtypes and their relevance
    Cecilia Gotti
    CNR, Institute of Neuroscience, Cellular and Molecular Pharmacology, Department of Medical Pharmacology and Center of Excellence on Neurodegenerative Diseases, University of Milan, 20129 Milan, Italy
    Trends Pharmacol Sci 27:482-91. 2006

Detail Information

Publications386 found, 100 shown here

  1. ncbi Nicotinic acetylcholine receptor alpha7 subunit is an essential regulator of inflammation
    Hong Wang
    Laboratory of Biomedical Science, North Shore Long Island Jewish Research Institute, 350 Community Drive, Manhasset, New York 11030, USA
    Nature 421:384-8. 2003
    ..Thus, the nicotinic acetylcholine receptor alpha7 subunit is essential for inhibiting cytokine synthesis by the cholinergic anti-inflammatory pathway...
  2. pmc Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1
    Christopher I Amos
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Nat Genet 40:616-22. 2008
    ..Haplotype analysis was consistent with there being a single risk variant in this region. We conclude that variation in a region of 15q25.1 containing nicotinic acetylcholine receptors genes contributes to lung cancer risk...
  3. ncbi A variant associated with nicotine dependence, lung cancer and peripheral arterial disease
    Thorgeir E Thorgeirsson
    deCODE Genetics, 101 Reykjavik, Iceland
    Nature 452:638-42. 2008
    ..The findings provide a case study of a gene-environment interaction, highlighting the role of nicotine addiction in the pathology of other serious diseases...
  4. ncbi A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25
    Rayjean J Hung
    International Agency for Research on Cancer IARC, Lyon 69008, France
    Nature 452:633-7. 2008
    ..Our results provide compelling evidence of a locus at 15q25 predisposing to lung cancer, and reinforce interest in nicotinic acetylcholine receptors as potential disease candidates and chemopreventative targets...
  5. pmc Mammalian nicotinic acetylcholine receptors: from structure to function
    Edson X Albuquerque
    Department of Pharmacology and Experimental Therapeutics, University of Maryland School of Medicine, Baltimore, MD, USA
    Physiol Rev 89:73-120. 2009
    ..Subsequent studies aided by the Torpedo electric organ, a rich source of muscle-type nicotinic receptors (nAChRs), and the discovery of alpha-bungarotoxin, a snake toxin that binds pseudo-irreversibly to the ..
  6. ncbi Refined structure of the nicotinic acetylcholine receptor at 4A resolution
    Nigel Unwin
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    J Mol Biol 346:967-89. 2005
    ..Access to the pore on the intracellular side is further influenced by narrow lateral windows, which would be expected to screen out electrostatically ions of the wrong charge and size...
  7. pmc Variants in nicotinic receptors and risk for nicotine dependence
    Laura Jean Bierut
    Department of Psychiatry, Washington University School of Medicine, Box 8134, 660 South Euclid Ave, St Louis, MO 63110, USA
    Am J Psychiatry 165:1163-71. 2008
    ..this study was to replicate these findings in an independent data set and more thoroughly investigate the role of genetic variation in the cluster of physically linked nicotinic receptors, CHRNA5-CHRNA3-CHRNB4, and the risk of smoking.
  8. pmc Cholinergic nicotinic receptor genes implicated in a nicotine dependence association study targeting 348 candidate genes with 3713 SNPs
    Scott F Saccone
    Department of Psychiatry, Box 8134, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Hum Mol Genet 16:36-49. 2007
    ..Other genes among the top signals were KCNJ6 and GABRA4. This study represents one of the most powerful and extensive studies of nicotine dependence to date and has found novel risk loci that require confirmation by replication studies...
  9. ncbi Nicotinic receptors: allosteric transitions and therapeutic targets in the nervous system
    Antoine Taly
    Laboratoire de Chimie Biophysique, Institut de Science et d Ingenierie Supramoleculaires, UMR 7006 CNRS Université de Strasbourg, 8 allee Gaspard Monge, 67000 Strasbourg, France
    Nat Rev Drug Discov 8:733-50. 2009
    b>Nicotinic receptors - a family of ligand-gated ion channels that mediate the effects of the neurotransmitter acetylcholine - are among the most well understood allosteric membrane proteins from a structural and functional perspective...
  10. ncbi Brain nicotinic acetylcholine receptors: native subtypes and their relevance
    Cecilia Gotti
    CNR, Institute of Neuroscience, Cellular and Molecular Pharmacology, Department of Medical Pharmacology and Center of Excellence on Neurodegenerative Diseases, University of Milan, 20129 Milan, Italy
    Trends Pharmacol Sci 27:482-91. 2006
    ....
  11. ncbi alpha 5 Subunit alters desensitization, pharmacology, Ca++ permeability and Ca++ modulation of human neuronal alpha 3 nicotinic receptors
    V Gerzanich
    Department of Neuroscience, University of Pennsylvania Medical School, Philadelphia, USA
    J Pharmacol Exp Ther 286:311-20. 1998
    ..In brain, by contrast, alpha 4 beta 2 AChRs were shown to predominate over alpha 3 AChRs. Some of the brain alpha 4 beta 2 AChRs were found to contain alpha 5 subunits...
  12. pmc Cholinergic stimulation blocks endothelial cell activation and leukocyte recruitment during inflammation
    Rubina W Saeed
    Laboratory of Medicinal Biochemistry, Institute for Medical Research at North Shore LIJ, Manhasset, NY 11030, USA
    J Exp Med 201:1113-23. 2005
    ..These findings identify the endothelium, a key regulator of leukocyte trafficking during inflammation, as a target of anti-inflammatory cholinergic mediators...
  13. ncbi Nicotine reinforcement and cognition restored by targeted expression of nicotinic receptors
    U Maskos
    Unité Récepteurs et Cognition, CNRS URA 2182, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
    Nature 436:103-7. 2005
    ..We thus demonstrate the sufficient role of the VTA in both nicotine reinforcement and endogenous cholinergic regulation of cognitive functions...
  14. pmc Crucial role of alpha4 and alpha6 nicotinic acetylcholine receptor subunits from ventral tegmental area in systemic nicotine self-administration
    S Pons
    Unité Neurobiologie Intégrative des Systèmes Cholinergiques, Institut Pasteur, 75724 Paris Cedex 15, France
    J Neurosci 28:12318-27. 2008
    ..We thus define the necessary and sufficient role of alpha4beta2- and alpha6beta2-subunit containing nicotinic receptors (alpha4beta2*- and alpha6beta2*-nAChRs), but not alpha7*-nAChRs, present in cell bodies of the VTA, and ..
  15. ncbi Nicotine activation of alpha4* receptors: sufficient for reward, tolerance, and sensitization
    Andrew R Tapper
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Science 306:1029-32. 2004
    ..These data indicate that activation of a4* receptors is sufficient for nicotine-induced reward, tolerance, and sensitization...
  16. pmc Structures of Aplysia AChBP complexes with nicotinic agonists and antagonists reveal distinctive binding interfaces and conformations
    Scott B Hansen
    Department of Pharmacology, University of California at San Diego, La Jolla, CA 92093 0636, USA
    EMBO J 24:3635-46. 2005
    ..This comprehensive set of structures reflects a dynamic template for delineating further conformational changes of the LBD of the nicotinic receptor...
  17. ncbi Synaptic mechanisms underlie nicotine-induced excitability of brain reward areas
    Huibert D Mansvelder
    Department of Anesthesia, University of Chicago, Chicago, IL 60637, USA
    Neuron 33:905-19. 2002
    ..These results suggest that spatial and temporal differences in nicotinic receptor activity on both excitatory and inhibitory neurons in reward areas coordinate to reinforce nicotine self-administration...
  18. pmc alpha10: a determinant of nicotinic cholinergic receptor function in mammalian vestibular and cochlear mechanosensory hair cells
    A B Elgoyhen
    Instituto de Investigaciones en Ingenieria, Genetica y Biologia Molecular, Consejo Nacional de Investigaciones Cientificas y Tecnicas, Universidad de Buenos Aires, Buenos Aires 1428, Argentina
    Proc Natl Acad Sci U S A 98:3501-6. 2001
    ..Our data suggest that efferent modulation of hair cell function occurs, at least in part, through heteromeric nAChRs assembled from both alpha9 and alpha10 subunits...
  19. ncbi The vagus nerve and nicotinic receptors modulate experimental pancreatitis severity in mice
    David J van Westerloo
    Laboratory of Experimental Internal Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Gastroenterology 130:1822-30. 2006
    ..This anti-inflammatory effect is mediated by an interaction of acetylcholine, the principal neurotransmitter of the vagus nerve, with macrophage cholinergic nicotinic receptors expressing the alpha7 subunit.
  20. ncbi Identification of sequence motifs that target neuronal nicotinic receptors to dendrites and axons
    Jian Xu
    Molecular Neurobiology Laboratory, The Salk Institute, La Jolla, California 92037, USA
    J Neurosci 26:9780-93. 2006
    ..These results provide valuable information in understanding diverse roles of neuronal nAChRs in mediating and modulating synaptic transmission, synaptic plasticity, and nicotine addiction...
  21. ncbi beta-Amyloid(1-42) peptide directly modulates nicotinic receptors in the rat hippocampal slice
    D L Pettit
    National Institute of Environmental Health Sciences, National Institutes of Health, Laboratory of Signal Transduction, Research Triangle Park, North Carolina 27709, USA
    J Neurosci 21:RC120. 2001
    ..Thus, chronic inhibition of cholinergic signaling by Abeta(1-42) could contribute to the cognitive deficits associated with AD...
  22. ncbi Nicotinic acetylcholine receptors and nicotinic cholinergic mechanisms of the central nervous system
    John A Dani
    Department of Neuroscience, Program of Structural and Computational Biology and Molecular Biophysics, Baylor College of Medicine, Houston, TX 77030, USA
    Annu Rev Pharmacol Toxicol 47:699-729. 2007
    ..Presynaptic and preterminal nicotinic receptors enhance neurotransmitter release, postsynaptic nAChRs contribute a small minority of fast excitatory ..
  23. ncbi Cholinergic modulation of microglial activation by alpha 7 nicotinic receptors
    R Douglas Shytle
    Child Development Center, Neuroimmunology Laboratory, Department of Psychiatry and Behavioral Medicine, University of South Florida College of Medciine, Tampa, Florida, USA
    J Neurochem 89:337-43. 2004
    ..suggest the existence of a brain cholinergic pathway that regulates microglial activation through alpha 7 nicotinic receptors. Negative regulation of microglia activation may also represent additional mechanism underlying nicotine's ..
  24. ncbi Beta-amyloid regulation of presynaptic nicotinic receptors in rat hippocampus and neocortex
    John J Dougherty
    Department of Pharmacology and Physiology, Drexel University College of Medicine, Philadelphia, Pennsylvania 19102, USA
    J Neurosci 23:6740-7. 2003
    ..Together, these results suggest that the sustained increases in presynaptic Ca2+ evoked by Abeta may underlie disruptions in neuronal signaling via nAChRs in the early stages of Alzheimer's disease...
  25. ncbi Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors
    K Brejc
    Division of Molecular Carcinogenesis, Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    Nature 411:269-76. 2001
    ..This AChBP structure is relevant for the development of drugs against, for example, Alzheimer's disease and nicotine addiction...
  26. ncbi Neonicotinoid insecticide toxicology: mechanisms of selective action
    Motohiro Tomizawa
    Environmental Chemistry and Toxicology Laboratory, Department of Environmental Science, Policy and Management, University of California, Berkeley, California 94720 3112, USA
    Annu Rev Pharmacol Toxicol 45:247-68. 2005
    ..The low affinity of neonicotinoids for vertebrate relative to insect nicotinic receptors is a major factor in their favorable toxicological profile.
  27. pmc The C. elegans ric-3 gene is required for maturation of nicotinic acetylcholine receptors
    Sarah Halevi
    Department of Physiology, Hebrew University Hadassah Medical School, Jerusalem 91120, Israel
    EMBO J 21:1012-20. 2002
    ..elegans DEG-3/DES-2 and of the rat alpha-7 acetylcholine receptors. Together, these data suggest that RIC-3 is specifically required for the maturation of acetylcholine receptors...
  28. ncbi Diversity of vertebrate nicotinic acetylcholine receptors
    Neil S Millar
    Department of Neuroscience, Physiology and Pharmacology, University College London, London WC1E 6BT, UK
    Neuropharmacology 56:237-46. 2009
    ..b>Nicotinic receptors are expressed in both the nervous system and at the neuromuscular junction and have been implicated in ..
  29. pmc Alpha7 nicotinic receptor subunits are not necessary for hippocampal-dependent learning or sensorimotor gating: a behavioral characterization of Acra7-deficient mice
    R Paylor
    Section on Behavioral Neuropharmacology, Experimental Therapeutics Branch, National Institute of Mental Health, Bethesda, Maryland 20892, USA
    Learn Mem 5:302-16. 1998
    ..Future studies will examine the contribution of alpha7 nAChR to the enhancement of learning and sensorimotor gating following nicotine treatments...
  30. pmc Nicotine inhibits the production of proinflammatory mediators in human monocytes by suppression of I-kappaB phosphorylation and nuclear factor-kappaB transcriptional activity through nicotinic acetylcholine receptor alpha7
    H Yoshikawa
    Department of Immunology and Medicine, Institute of Advanced Medical Science, St Marianna Graduate School of Medicine, Kawasaki, Japan
    Clin Exp Immunol 146:116-23. 2006
    ..Nicotine suppressed the phosphorylation of I-kappaB, and then inhibited the transcriptional activity of nuclear factor-kappaB. These immunosuppressive effects of nicotine may contribute to the regulation of some immune diseases...
  31. ncbi Emerging structure of the nicotinic acetylcholine receptors
    Arthur Karlin
    Center for Molecular Recognition, Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York 10032, USA
    Nat Rev Neurosci 3:102-14. 2002
    ..The location and structure of the gates, and the coupling between binding sites and gates, remain to be established...
  32. ncbi Ca2+ permeability of nicotinic acetylcholine receptors
    Sergio Fucile
    Dipartimento di Fisiologia Umana e Farmacologia, Universita di Roma La Sapienza, P le Aldo Moro 5, I 00185 Rome, Italy
    Cell Calcium 35:1-8. 2004
    ..Different experimental approaches are compared, and the structural determinants of Ca(2+) permeability are discussed...
  33. ncbi Nicotinic receptors in the rat prefrontal cortex: increase in glutamate release and facilitation of mediodorsal thalamo-cortical transmission
    Y Gioanni
    INSERM U114, College de France, Paris, France
    Eur J Neurosci 11:18-30. 1999
    ..Such a mechanism may be relevant to the cognitive effects of nicotine and nicotinic antagonists...
  34. pmc Prostate stem cell antigen is an endogenous lynx1-like prototoxin that antagonizes alpha7-containing nicotinic receptors and prevents programmed cell death of parasympathetic neurons
    Martin Hruska
    Department of Anatomy, University of Vermont College of Medicine, Burlington, Vermont 05405, USA
    J Neurosci 29:14847-54. 2009
    ....
  35. ncbi Nicotinic receptors mediate tumorigenic action of tobacco-derived nitrosamines on immortalized oral epithelial cells
    Juan Arredondo
    Department of Dermatology, University of California at Davis, Davis, California, USA
    Cancer Biol Ther 5:511-7. 2006
    ..The obtained results establish the role of specific nAChR subtypes in tobacco-related carcinogenesis and open a novel avenue for oral cancer chemoprevention...
  36. pmc Nicotine inhibits apoptosis induced by chemotherapeutic drugs by up-regulating XIAP and survivin
    Piyali Dasgupta
    Department of Interdisciplinary Oncology, H Lee Moffitt Cancer Center and Research Institute, University of South Florida, 12902 Magnolia Drive, Tampa, FL 33647, USA
    Proc Natl Acad Sci U S A 103:6332-7. 2006
    ..These studies suggest that exposure to nicotine might negatively impact the apoptotic potential of chemotherapeutic drugs and that survivin and XIAP play a key role in the antiapoptotic activity of nicotine...
  37. ncbi Roles of accessory subunits in alpha4beta2(*) nicotinic receptors
    Alexandre Kuryatov
    Department of Neuroscience, University of Pennsylvania Medical School, 217 Stemmler Hall, 36th and Hamilton Walk, Philadelphia, PA 19104, USA
    Mol Pharmacol 74:132-43. 2008
    Accessory subunits in heteromeric nicotinic receptors (AChRs) do not take part in forming ACh binding sites. alpha5 and beta3 subunits can function only as accessory subunits...
  38. pmc AChBP-targeted alpha-conotoxin correlates distinct binding orientations with nAChR subtype selectivity
    Sebastien Dutertre
    Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia
    EMBO J 26:3858-67. 2007
    ..Together, these results establish a new pharmacophore for the design of novel subtype-selective ligands with therapeutic potential in nAChR-related diseases...
  39. ncbi Structural and functional diversity of native brain neuronal nicotinic receptors
    Cecilia Gotti
    Department of Medical Pharmacology, CNR, Institute of Neuroscience, Cellular and Molecular Pharmacology, University of Milan, Milan, Italy
    Biochem Pharmacol 78:703-11. 2009
    ..We also discuss recent findings concerning the effect of chronic nicotine on the expression of native subtypes...
  40. ncbi Nicotinic effects on cognitive function: behavioral characterization, pharmacological specification, and anatomic localization
    Edward D Levin
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Box 3412, Durham, NC 27710, USA
    Psychopharmacology (Berl) 184:523-39. 2006
    ..Nicotine has been shown in a variety of studies in humans and experimental animals to improve cognitive function. Nicotinic treatments are being developed as therapeutic treatments for cognitive dysfunction...
  41. ncbi Desensitization of nicotinic ACh receptors: shaping cholinergic signaling
    Rashid Giniatullin
    Neurobiology Sector and INFM Unit, International School for Advanced Studies SISSA, Via Beirut 4, 34014, Trieste, Italy
    Trends Neurosci 28:371-8. 2005
    ....
  42. ncbi A neuronal nicotinic acetylcholine receptor subunit (alpha 7) is developmentally regulated and forms a homo-oligomeric channel blocked by alpha-BTX
    S Couturier
    Department of Biochemistry, University of Geneva, Switzerland
    Neuron 5:847-56. 1990
    ..A bacterial fusion protein encompassing residues 124-239 of alpha 7 binds labeled alpha-bungarotoxin. We conclude that alpha-bungarotoxin binding proteins in the vertebrate nervous system can function as nAChRs...
  43. pmc Nicotinic receptors in the habenulo-interpeduncular system are necessary for nicotine withdrawal in mice
    Ramiro Salas
    Department of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosci 29:3014-8. 2009
    ..Our data suggest that the efforts to develop new smoking cessation therapies should concentrate on these areas and receptor types...
  44. ncbi Two types of nicotinic receptors mediate an excitation of neocortical layer I interneurons
    Elodie Christophe
    Laboratoire de Neurophysiologie, Institut National de la Santé et de la Recherche Médicale EPI 0002, ESPCI, 75231 Paris Cedex 5, France
    J Neurophysiol 88:1318-27. 2002
    ..addition of Cd(2+) or tetrodotoxin, indicating that they were mediated by direct activation of postsynaptic nicotinic receptors. The kinetics of the currents and their sensitivity to nicotinic receptor antagonists, methyllycaconitine (..
  45. ncbi Human bronchial epithelial and endothelial cells express alpha7 nicotinic acetylcholine receptors
    Y Wang
    Department of Pharmacology, University of Minnesota, Minneapolis, Minnesota, USA
    Mol Pharmacol 60:1201-9. 2001
    ..The presence of alpha7 nAChRs in BEC and AEC suggests that some toxic effects of tobacco smoke could be mediated through these nicotine-sensitive receptors...
  46. ncbi A Dalpha6 knockout strain of Drosophila melanogaster confers a high level of resistance to spinosad
    Trent Perry
    Department of Genetics, Centre for Environmental Stress and Adaptation Research, Bio21 Institute, University of Melbourne, Parkville, Victoria, Australia
    Insect Biochem Mol Biol 37:184-8. 2007
    ..This, combined with the high degree of evolutionary conservation of nAChR subunits, suggests that mutations in Dalpha6 orthologues may underpin the spinosad resistance identified in several economically important field pests...
  47. pmc Peroxisome proliferator-activated receptors-alpha modulate dopamine cell activity through nicotinic receptors
    Miriam Melis
    B B Brodie Department of Neuroscience, University of Cagliari, Monserrato, Italy
    Biol Psychiatry 68:256-64. 2010
    ..Among these, endogenous ligands to the nuclear receptor-transcription factor peroxisome proliferator-activated receptors type-alpha (PPARalpha) have been recently found to suppress nicotine-induced responses of dopamine neurons...
  48. ncbi Cholinergic synaptic inhibition of inner hair cells in the neonatal mammalian cochlea
    E Glowatzki
    The Center for Hearing Sciences, Department of Otolaryngology Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Science 288:2366-8. 2000
    ..The synaptic currents, as well as the inner hair cell's response to acetylcholine, are mediated by a nicotinic (alpha9-containing) receptor and result in the activation of small-conductance calcium-dependent potassium channels...
  49. ncbi Nicotine addiction and nicotinic receptors: lessons from genetically modified mice
    Jean Pierre Changeux
    Collge de France and the Institut Pasteur CNRS URA 2182, 25 rue du Dr Roux, 75015 Paris, France
    Nat Rev Neurosci 11:389-401. 2010
    ....
  50. ncbi Alternate stoichiometries of alpha4beta2 nicotinic acetylcholine receptors
    Mark E Nelson
    Department of Neuroscience, University of Pennsylvania Medical School, Philadelphia, Pennsylvania 19104, USA
    Mol Pharmacol 63:332-41. 2003
    ..Alternate alpha4beta2 nAChR stoichiometries with distinct functional properties raise the possibility for an interesting mode of synaptic regulation for nicotinic signaling in the mammalian brain...
  51. ncbi Molecular cloning, functional properties, and distribution of rat brain alpha 7: a nicotinic cation channel highly permeable to calcium
    P Seguela
    Division of Neuroscience, Baylor College of Medicine, Houston, Texas 77030
    J Neurosci 13:596-604. 1993
    ..These results imply that alpha 7-containing receptors may play a role in activating calcium-dependent mechanisms in specific neuronal populations of the adult rat limbic system...
  52. pmc Novel human alpha9 acetylcholine receptor regulating keratinocyte adhesion is targeted by Pemphigus vulgaris autoimmunity
    V T Nguyen
    Department of Dermatology, University of California at Davis, Sacramento, California, USA
    Am J Pathol 157:1377-91. 2000
    ..We conclude that alpha9 is coupled to physiological regulation of keratinocyte adhesion, and its interaction with PV IgG may lead to blister development...
  53. pmc Functional characterization of alpha9-containing cholinergic nicotinic receptors in the rat adrenal medulla: implication in stress-induced functional plasticity
    Claude Colomer
    Institute of Functional Genomics, Centre National de la Recherche Scientifique, Unite Mixte de Recherche 5203, Institut National de la Sante et de la Recherche Medicale U661, University of Montpellier, 34094 Montpellier, France
    J Neurosci 30:6732-42. 2010
    ..Since synaptic transmission is mainly supported by activation of postsynaptic neuronal acetylcholine nicotinic receptors (nAChRs), we focused our study on the role of alpha9-containing nAChRs, which have been recently described ..
  54. ncbi Increased severity of experimental colitis in alpha 5 nicotinic acetylcholine receptor subunit-deficient mice
    Avi Orr-Urtreger
    The Genetics Institute, Tel Aviv Sourasky Medical Center, Tel Aviv University, Tel Aviv, Israel
    Neuroreport 16:1123-7. 2005
    ..These findings suggest that alpha5-containing nicotinic acetylcholine receptors participate in the modulation of colitis in mice, but other nicotinic acetylcholine receptor subunits also mediate the antiinflammatory effects of nicotine...
  55. ncbi Neuronal nicotinic receptor alpha 6 subunit mRNA is selectively concentrated in catecholaminergic nuclei of the rat brain
    N Le Novère
    CNRS URA 1284, Pasteur Institute, Paris, France
    Eur J Neurosci 8:2428-39. 1996
    ..This suggests the involvement of the alpha 6 subunit in some of the major functions of central nicotinic circuits, including the modulation of locomotor behaviour and reward...
  56. ncbi Broad-spectrum efficacy across cognitive domains by alpha7 nicotinic acetylcholine receptor agonism correlates with activation of ERK1/2 and CREB phosphorylation pathways
    Robert S Bitner
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, Illinois 60064, USA
    J Neurosci 27:10578-87. 2007
    ....
  57. ncbi Nicotinic acetylcholine receptors containing alpha 7 subunits on rat cortical neurons do not undergo long-lasting inactivation even when up-regulated by chronic nicotine exposure
    H Kawai
    Neurobiology Section, Division of Biology, University of California, San Diego, La Jolla, California 92093-0357, USA
    J Neurochem 78:1367-78. 2001
    ..b>Nicotinic receptors containing alpha 7 subunits are among the most abundant in brain and influence diverse cellular events...
  58. ncbi Differential coupling of M1 muscarinic and alpha7 nicotinic receptors to inhibition of pemphigus acantholysis
    Alex I Chernyavsky
    Department of Dermatology, University of California, Irvine, California 92697, USA
    J Biol Chem 283:3401-8. 2008
    ..These findings identified novel paradigm of regulation of signaling kinases associated with cholinergic receptors and provided mechanistic explanation of therapeutic activity of cholinomimetics in PV patients...
  59. pmc Molecular mechanism for analgesia involving specific antagonism of alpha9alpha10 nicotinic acetylcholine receptors
    Michelle Vincler
    Department of Anesthesiology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Proc Natl Acad Sci U S A 103:17880-4. 2006
    ..Our findings not only suggest a molecular mechanism for the treatment of neuropathic pain but also demonstrate the involvement of alpha9alpha10 nAChRs in the pathophysiology of peripheral nerve injury...
  60. ncbi Adaptive evolution in mammalian proteins involved in cochlear outer hair cell electromotility
    Lucia F Franchini
    Instituto de Investigaciones en Ingenieria Genetica y Biologia Molecular, Consejo Nacional de Investigaciones Cientificas y Tecnicas, Buenos Aires, Argentina
    Mol Phylogenet Evol 41:622-35. 2006
    ..This finding is most likely related with the roles these proteins play in somatic electromotility and/or its fine tuning...
  61. ncbi Nicotinic receptor subtypes in human brain ageing, Alzheimer and Lewy body diseases
    E Perry
    Department of Neuropathology, MRC Neurochemical Pathology Unit, Newcastle General Hospital, Westgate Road, Newcastle, UK
    Eur J Pharmacol 393:215-22. 2000
    Human brain ageing is associated with reductions in a variety of nicotinic receptors subtypes, whereas changes in age-related disorders including Alzheimer's disease or Parkinson's disease are more selective...
  62. ncbi Genetic variants on chromosome 15q25 associated with lung cancer risk in Chinese populations
    Chen Wu
    Department of Etiology and Carcinogenesis and State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
    Cancer Res 69:5065-72. 2009
    ..These results support 15q25 as a susceptibility region for lung cancer in Chinese but underscore the difference in genetic markers among different ethnic populations...
  63. pmc Identification and characterization of novel nicotinic receptor-associated proteins in Caenorhabditis elegans
    Alexander Gottschalk
    Institute for Biochemistry, Goethe University, Frankfurt, Germany
    EMBO J 24:2566-78. 2005
    ..Thus, tandem affinity purification is a viable approach to identify novel proteins regulating neurotransmitter receptor activity or expression in model systems like C. elegans...
  64. ncbi Molecular cloning and mapping of the human nicotinic acetylcholine receptor alpha10 (CHRNA10)
    L R Lustig
    The Center for Hearing Sciences, Johns Hopkins University, Baltimore, Maryland 21205, USA
    Genomics 73:272-83. 2001
    ..We also detected the expression of the human nAChR alpha9 (CHRNA9) mRNA in these same tissues using RT-PCR and Northern blot hybridization...
  65. ncbi Immunohistochemical localisation of nicotinic acetylcholine receptor subunits in human cerebellum
    A Graham
    Joint MRC University of Newcastle upon Tyne, Centre Development in Clinical Brain Ageing, MRC Building, Newcastle General Hospital, Westgate Road, NE4 6BE, Newcastle upon Tyne, UK
    Neuroscience 113:493-507. 2002
    ..Further investigations are warranted to evaluate the participation of nicotinic acetylcholine receptors in cerebellar pathology associated with both developmental and age-related disorders...
  66. ncbi Neonicotinoid insecticides display partial and super agonist actions on native insect nicotinic acetylcholine receptors
    Laurence A Brown
    Department of Physiology, Anatomy and Genetics, MRC Functional Genetics Unit, Le Gros Clark Building, University of Oxford, South Parks Road, Oxford, UK
    J Neurochem 99:608-15. 2006
    ..Cell-attached recordings indicate that super agonism results from more frequent openings at the largest (63.5 pS) conductance state observed...
  67. ncbi Selective toxicity of neonicotinoids attributable to specificity of insect and mammalian nicotinic receptors
    Motohiro Tomizawa
    Environmental Chemistry and Toxicology Laboratory, Department of Environmental Science, Policy and Management, University of California, Berkeley, California 94720 3112, USA
    Annu Rev Entomol 48:339-64. 2003
    ....
  68. ncbi Alpha7-nicotinic acetylcholine receptors mediate an Abeta(1-42)-induced increase in the level of acetylcholinesterase in primary cortical neurones
    L R Fodero
    Department of Pathology, University of Melbourne, Parkville, Australia
    J Neurochem 88:1186-93. 2004
    ..The results demonstrate that the effect of Abeta1-42 on AChE is due to an agonist effect of Abeta1-42 on the alpha7 nAChR...
  69. pmc Association between a 15q25 gene variant, smoking quantity and tobacco-related cancers among 17 000 individuals
    Esther H Lips
    International Agency for Research on Cancer IARC, Lyon, France
    Int J Epidemiol 39:563-77. 2010
    ....
  70. ncbi "Orphan" alpha6 nicotinic AChR subunit can form a functional heteromeric acetylcholine receptor
    V Gerzanich
    Department of Neuroscience, University of Pennsylvania Medical School, Philadelphia 19104 6074, USA
    Mol Pharmacol 51:320-7. 1997
    ..Therefore, alpha6 can function as part of AChRs with unusual pharmacological properties...
  71. pmc Association of serum cotinine level with a cluster of three nicotinic acetylcholine receptor genes (CHRNA3/CHRNA5/CHRNB4) on chromosome 15
    Kaisu Keskitalo
    Department of Public Health, University of Helsinki, Finland
    Hum Mol Genet 18:4007-12. 2009
    ..13 for CPD. Variation at CHRNA5/CHRNA3/CHRNB4 cluster influences nicotine level, measured as cotinine, more strongly than smoking quantity, measured by CPD, and appears thus to be involved in regulation of nicotine levels among smokers...
  72. pmc Central cholinergic regulation of respiration: nicotinic receptors
    Xuesi M Shao
    Department of Neurobiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1763, USA
    Acta Pharmacol Sin 30:761-70. 2009
    ....
  73. pmc Nicotine binding to brain receptors requires a strong cation-pi interaction
    Xinan Xiu
    Division of Chemistry and Chemical Engineering, California Institute of Technology, 1200 East California Boulevard, Pasadena, California 91125, USA
    Nature 458:534-7. 2009
    ..Along with solving a chemical mystery in nicotine addiction, our results provide guidance for efforts to develop drugs that target specific types of nicotinic receptors.
  74. pmc The CHRNA5/A3/B4 gene cluster variability as an important determinant of early alcohol and tobacco initiation in young adults
    Isabel R Schlaepfer
    Institute for Behavioral Genetics, Department of Integrative Physiology, University of Colorado, Boulder, CO 80309, USA
    Biol Psychiatry 63:1039-46. 2008
    ..Significant results were then replicated in a separate adult population-representative sample...
  75. ncbi Involvement of nicotinic acetylcholine receptors in suppression of antimicrobial activity and cytokine responses of alveolar macrophages to Legionella pneumophila infection by nicotine
    K Matsunaga
    Department of Medical Microbiology and Immunology, University of South Florida College of Medicine, Tampa, FL 33612, USA
    J Immunol 167:6518-24. 2001
    ....
  76. pmc Nicotinic receptor gene variants influence susceptibility to heavy smoking
    Victoria L Stevens
    Department of Epidemiology and Surveillance Research, American Cancer Society, 250 Williams Street Northwest, Atlanta, GA 30303 1002, USA
    Cancer Epidemiol Biomarkers Prev 17:3517-25. 2008
    ..Our findings identify two loci in the CHRNA5-CHRNA3-CHRNB4 gene cluster that predict smoking behavior and provide strong evidence for the involvement of the alpha5 nicotinic receptor in heavy smoking...
  77. ncbi Nicotinic receptors, amyloid-beta, and synaptic failure in Alzheimer's disease
    Sofia Jürgensen
    Institute of Medical Biochemistry, Federal University of Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, 21944 590, Brazil
    J Mol Neurosci 40:221-9. 2010
    ..This review examines recent progress in our understanding of the roles of nicotinic receptors in mechanisms of synaptic plasticity, molecular interactions of Abeta with nAChRs, and how Abeta-induced ..
  78. ncbi Effects of imidacloprid metabolites on habituation in honeybees suggest the existence of two subtypes of nicotinic receptors differentially expressed during adult development
    D Guez
    Visual Sciences, Research School of Biological Sciences, Australian National University, Canberra, ACT 0200, Australia
    Pharmacol Biochem Behav 75:217-22. 2003
    ..The implications of this finding for the honeybee biology are discussed...
  79. ncbi Insect nicotinic acetylcholine receptor gene families: from genetic model organism to vector, pest and beneficial species
    Andrew K Jones
    MRC Functional Genetics Unit, Department of Physiology, Anatomy and Genetics, University of Oxford, Le Gros Clark Building, South Parks Road, Oxford, OX1 3QX, UK
    Invert Neurosci 7:67-73. 2007
    ..Unitary conductance measurements on native nAChRs indicate that more frequent openings of the largest conductance state may offer an explanation for the superagonist actions of clothianidin...
  80. pmc Crystal structure of a Cbtx-AChBP complex reveals essential interactions between snake alpha-neurotoxins and nicotinic receptors
    Yves Bourne
    Architecture et Fonction des Macromolecules Biologiques, CNRS UMR 6098, Marseille, France
    EMBO J 24:1512-22. 2005
    ....
  81. pmc Behavioral sequence analysis reveals a novel role for beta2* nicotinic receptors in exploration
    Nicolas Maubourguet
    Unité Neurobiologie Intégrative des Systèmes Cholinergiques, Institut Pasteur, Paris, France
    PLoS Comput Biol 4:e1000229. 2008
    ....
  82. pmc Defining pre-synaptic nicotinic receptors regulated by beta amyloid in mouse cortex and hippocampus with receptor null mutants
    Tejal K Mehta
    Department of Pharmacology and Physiology, Drexel University College of Medicine, Philadelphia, PA, USA
    J Neurochem 109:1452-8. 2009
    ..to nM) on isolated pre-synaptic terminals to increase [Ca(2+)]i, with apparent involvement of pre-synaptic nicotinic receptors. To directly establish the role of nicotinic receptors in pre-synaptic Ca(2+) regulation, we investigated ..
  83. ncbi Nicotinic receptor-mediated activation by the tobacco-specific nitrosamine NNK of a Raf-1/MAP kinase pathway, resulting in phosphorylation of c-myc in human small cell lung carcinoma cells and pulmonary neuroendocrine cells
    B A Jull
    Experimental Oncology Laboratory, College of Veterinary Medicine, University of Tennessee, Knoxville 37901-1071, USA
    J Cancer Res Clin Oncol 127:707-17. 2001
    ..Furthermore, our data suggest that serotonin uptake inhibitors may protect against the development or be useful in the clinical management of SCLC...
  84. ncbi Chronic exposure to estrogen and the tobacco carcinogen NNK cooperatively modulates nicotinic receptors in small airway epithelial cells
    Hussein A N Al-Wadei
    Experimental Oncology Laboratory, University of Tennessee, Knoxville, TN 37996, USA
    Lung Cancer 69:33-9. 2010
    ..This selective imbalance in stimulatory and inhibitory signaling may contribute to the development and progression of small airway-derived adenocarcinoma in women who smoke...
  85. ncbi Selective alpha7-nicotinic acetylcholine receptor agonist GTS-21 improves survival in murine endotoxemia and severe sepsis
    Valentin A Pavlov
    Laboratory of Biomedical Science, The Feinstein Institute for Medical Research, Manhasset, NY, USA
    Crit Care Med 35:1139-44. 2007
    ..Here we studied whether GTS-21, a selective alpha7-nicotinic acetylcholine receptor agonist, inhibits proinflammatory cytokines in vitro and in vivo and improves survival in murine endotoxemia and severe sepsis...
  86. pmc A novel angiogenic pathway mediated by non-neuronal nicotinic acetylcholine receptors
    Christopher Heeschen
    Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, California 94305, USA
    J Clin Invest 110:527-36. 2002
    ..To our knowledge, this is the first description of a cholinergic angiogenic pathway, and it suggests a novel avenue for therapeutic modulation of angiogenesis...
  87. ncbi Neonicotinoids: insecticides acting on insect nicotinic acetylcholine receptors
    K Matsuda
    Laboratory of Pesticide Chemistry, Dept of Agricultural Chemistry, Faculty of Agriculture, Kinki University, 3327-204 Nakamachi, 631-8505, Nara, Japan
    Trends Pharmacol Sci 22:573-80. 2001
    ..Chemical calculation of atomic charges of the insecticide molecule and a site-directed mutagenesis study support this hypothesis...
  88. ncbi Nicotinic acetylcholine receptors: targets for commercially important insecticides
    Neil S Millar
    Department of Pharmacology, University College London, Gower Street, London, WC1E 6BT, UK
    Invert Neurosci 7:53-66. 2007
    ..As with other classes of insecticides, there is growing evidence for the evolution of resistance to insecticides that act on nAChRs...
  89. ncbi Association of the neuronal nicotinic receptor beta2 subunit gene (CHRNB2) with subjective responses to alcohol and nicotine
    Marissa A Ehringer
    Institute for Behavioral Genetics, University of Colorado, Boulder, Colorado 80309, USA
    Am J Med Genet B Neuropsychiatr Genet 144:596-604. 2007
    ..This study provides the first evidence for association between the CHRNB2 gene and nicotine- and alcohol-related phenotypes, and suggests that polymorphisms in CHRNB2 may be important in mediating early responses to nicotine and alcohol...
  90. pmc Rodent habenulo-interpeduncular pathway expresses a large variety of uncommon nAChR subtypes, but only the alpha3beta4* and alpha3beta3beta4* subtypes mediate acetylcholine release
    Sharon R Grady
    Institute for Behavioral Genetics, University of Colorado, Boulder, Colorado 80301, USA
    J Neurosci 29:2272-82. 2009
    Recent studies suggest that the neuronal nicotinic receptors (nAChRs) present in the habenulo-interpeduncular (Hb-IPn) system can modulate the reinforcing effect of addictive drugs and the anxiolytic effect of nicotine...
  91. pmc beta -Amyloid peptide blocks the response of alpha 7-containing nicotinic receptors on hippocampal neurons
    Q Liu
    Neurobiology Section, Division of Biology, University of California at San Diego, La Jolla, CA 92093-0357, USA
    Proc Natl Acad Sci U S A 98:4734-9. 2001
    ....
  92. ncbi Nicotinic receptor stimulation protects nigral dopaminergic neurons in rotenone-induced Parkinson's disease models
    Hiroki Takeuchi
    Department of Neurology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    J Neurosci Res 87:576-85. 2009
    ..These results suggest that the rotenone mouse model may be useful for assessing candidate antiparkinson agents, and that nAChR (nicotinic acetylcholine receptor) stimulation can protect DA neurons against degeneration...
  93. ncbi Desensitizing and non-desensitizing subtypes of alpha-bungarotoxin-sensitive nicotinic acetylcholine receptors in cockroach neurons
    Vincent L Salgado
    Bayer CropScience AG, Global Biology Insecticides, Alfred Nobel Strasse 50, D 40789 Monheim am Rhein, Germany
    J Insect Physiol 50:867-79. 2004
    ..Spinosyn A weakly antagonizes nAChD receptors -23% at 10 microM. The roles of the two nAChR subtypes in insecticide poisoning are discussed...
  94. pmc Nicotine-induced upregulation of nicotinic receptors: underlying mechanisms and relevance to nicotine addiction
    Anitha P Govind
    Department of Neurobiology, University of Chicago, Abbot Hall 402 MC0926, Chicago, IL 60637, USA
    Biochem Pharmacol 78:756-65. 2009
    ..its receptors in the mesolimbic dopamine system, particularly ventral tegmental area (VTA) neurons, where nicotinic receptors act to modulate the release of dopamine...
  95. pmc Cigarette smoking saturates brain alpha 4 beta 2 nicotinic acetylcholine receptors
    Arthur L Brody
    Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA 90095, USA
    Arch Gen Psychiatry 63:907-15. 2006
    ....
  96. pmc The nicotinic acetylcholine receptor gene family of the honey bee, Apis mellifera
    Andrew K Jones
    MRC Functional Genetics Unit, Department of Physiology Anatomy and Genetics, University of Oxford, Oxford OX1 3QX, United Kingdom
    Genome Res 16:1422-30. 2006
    ..These findings on Apis mellifera enhance our understanding of nAChR functional genomics and provide a useful basis for the development of improved insecticides that spare a major beneficial insect species...
  97. ncbi The Ror receptor tyrosine kinase CAM-1 is required for ACR-16-mediated synaptic transmission at the C. elegans neuromuscular junction
    Michael M Francis
    Department of Biology, University of Utah, Salt Lake City 84112, USA
    Neuron 46:581-94. 2005
    ..We hypothesize that CAM-1 contributes to the localization or stabilization of postsynaptic ACR-16 receptors and presynaptic release sites...
  98. ncbi Differential desensitization and distribution of nicotinic acetylcholine receptor subtypes in midbrain dopamine areas
    Julian R A Wooltorton
    Division of Neuroscience, Baylor College of Medicine, Houston, Texas 77030 3498, USA
    J Neurosci 23:3176-85. 2003
    ....
  99. ncbi Contribution of nicotine acetylcholine receptor polymorphisms to lung cancer risk in a smoking-independent manner in the Japanese
    Kouya Shiraishi
    Biology Division, National Cancer Center Research Institute, National Cancer Center Hospital, Tokyo, Japan
    Carcinogenesis 30:65-70. 2009
    ..These results strongly indicate that CHRNA SNPs confer lung cancer susceptibility in a small subset of Japanese in a smoking-independent manner...
  100. ncbi Nicotinic receptor abnormalities of Alzheimer's disease: therapeutic implications
    A Nordberg
    Department of Neurotec, Division of Molecular Neuropharmacology, Karolinska Institute, Huddinge University Hospital, Huddinge, Sweden
    Biol Psychiatry 49:200-10. 2001
    ..Treatment with cholinergic drugs in AD patients indicate improvement of the nAChRs in the brain, as visualized by PET. Further studies on neuroprotective mechanisms mediated via nAChR subtypes are exciting new avenues...
  101. ncbi Nicotinic receptors in aging and dementia
    Marina R Picciotto
    Department of Psychiatry, Yale University School of Medicine, 34 Park Street, New Haven, Connecticut 06508, USA
    J Neurobiol 53:641-55. 2002
    ..We will also present hypotheses that might address the mechanisms underlying the ability of nAChR function to protect against neurodegeneration or improve cognition, two potentially distinct actions of nicotine...

Research Grants74

  1. Multi-targeted Countermeasures against Acute and Delayed Effects of OP Exposure
    John A Butera; Fiscal Year: 2013
    ..in the synapse;resulting in excitotoxic levels of acetylcholine and hypersensitization of muscarinic and nicotinic receptors. This overload of excitotoxic chemicals incapacitates the victim via cholinergic toxidrome, resulting in ..
  2. The Habenulo-Interpeduncular Pathway and Nicotine
    Christie D Fowler; Fiscal Year: 2013
    ..abstract_text> ..
  3. Nicotinic Acetylcholine Receptor Density and Veteran Cigarette Smokers
    Arthur Brody; Fiscal Year: 2013
    ....
  4. KINETICS OF DRUG MACROMOLECULE COMPLEX FORMATION
    PALMER WILLIAM TAYLOR; Fiscal Year: 2013
    ....
  5. Modulation of cancer prevention by social stress
    Hildegard M Schuller; Fiscal Year: 2010
    ....
  6. Resolving the role of nicotine-mediated phosphorylation on pancreatic fibrosis
    Joao A Paulo; Fiscal Year: 2013
    ..The proposed work is reflective of the progression from my graduate school work on nicotinic receptors, to my current postdoctoral research searching for pancreatic biomarkers using mass spectrometry, and now ..
  7. Role of Id1 in NSCLC Progression and Metastasis
    Srikumar P Chellappan; Fiscal Year: 2013
    ..We believe that an in-depth mechanistic analysis as proposed in this application will lead to the development of novel therapeutic agents for non-small cell lungs cancer based on targeting the Id1 protein. ..
  8. Brain Nicotine Receptor Density &Response to Nicotine Patch
    Arthur Brody; Fiscal Year: 2013
    ..Additionally, we will explore whether the combination of information from the PET images and rating scales can be used to identify even more robustly who will quit smoking with nicotine patch treatment. ..
  9. ULTRASTRUCTURE OF MESOLIMBIC TRANSMITTER INTERACTIONS
    Virginia M Pickel; Fiscal Year: 2012
    ..abstract_text> ..
  10. Neural Actions of Toluene
    John J Woodward; Fiscal Year: 2013
    ..Research to be carried out in this proposal will provide a detailed analysis of the effects of abused inhalants on neurons within brain areas involved in addiction. ..
  11. Polymorphism and mutation spectrum in minorities with non-small cell lung cancer
    David P Carbone; Fiscal Year: 2010
    ..The results should provide tremendous insight into the genomic factors which influence susceptibility, pathogenesis, drug sensitivity, and survival in African-Americans with non-small cell lung cancer. ..
  12. Biobehavioral Role of Brain Kynurenine Metabolism in Mental Illness
    JASON C O'CONNOR; Fiscal Year: 2013
    ..Successfully unraveling these molecular networks will enable the development of novel therapeutic strategies to treat inflammation-induced depression. ..
  13. Nicotinic receptor stimulation and epigenetic regulation of GABAergic function.
    Alessandro Guidotti; Fiscal Year: 2013
    ....
  14. Genetic Determinants of Drug Effects
    Tamara J Phillips; Fiscal Year: 2012
    ..Further, our investigations are likely to render mechanisms that can be translationally studied in VA and other clinical populations. ..
  15. Targeting of alpha7 nAChR for therapeutic effects
    Roger L Papke; Fiscal Year: 2013
    ..We will use our new discoveries about how these drugs work to help make alpha7-stimulating drugs optimally designed to treat specific diseases. ..
  16. Adhesion Mechanisms Mediating Sickle Cell Vasooclusion In Vivo
    Paul S Frenette; Fiscal Year: 2013
    ..These studies will provide new insight on the mechanisms regulating sickle cell VOC and lead to novel ways to target inflammation. ..
  17. Novel lead molecule optimization targeting nicotinic receptor subtypes
    DENNIS BRIAN contact MCKAY; Fiscal Year: 2010
    ..b>Nicotinic receptors and their many subtypes are linked to a number of neurological diseases such as schizophrenia, attention ..
  18. Signal transduction in TRPM5-expressing olfactory sensory neurons
    Diego Restrepo; Fiscal Year: 2010
    ..Thus, the FIRCA application would contribute to the link between basic science and clinically oriented research in the US and Chile. ..
  19. Models for?functional evaluation of?CHRN polymorphisms
    Beverly H Koller; Fiscal Year: 2012
    ....
  20. Hybrid atomic force-optical imaging system to investigate prenatal nicotine
    Jeffrey Potts; Fiscal Year: 2009
    ..b>Nicotinic receptors are expressed on peripheral (carotid body) and central (brainstem neurons) structures that are involved in ..
  21. MiR-223 Regulation of Blood-Brain Barrier Function After Traumatic Brain Injury
    John B Redell; Fiscal Year: 2013
    ....
  22. The Role of the Nicotinic Cholinergic Pathway in Retinopathy of Prematurity
    John P Cooke; Fiscal Year: 2013
    ..abstract_text> ..
  23. Ethanol modulation of nicotinic receptors
    John McDaid; Fiscal Year: 2013
    ..These receptors and this brain region may therefore represent a target for future drug therapies to curb smoking and drinking behaviors while at the same time reducing fatalities caused by alcohol impairment. ..
  24. Alpha4 Nicotinic Receptor in Addiction: Mouse Models
    Henry A Lester; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: Roughly 400,000 Americans and roughly 4,000,000 people worldwide die annually of the sequelae to nicotine dependence. This project attempts to explain nicotine dependence. ..
  25. Gender Effects on Amphetamine-Induced Dopamine Release and Subjective Responses
    Mary E McCaul; Fiscal Year: 2013
    ..These differences have been attributed to acute and chronic effects of ovarian steroid hormones on nicotinic receptors, although findings have not been conclusive...
  26. Nicotine, nicotinic receptors and lung cancer
    Eliot R Spindel; Fiscal Year: 2013
    ..The nicotinic receptors are ligand-gated ion channels composed of 5 subunits, either a mixture of a and [unreadable] subunits or 5 ..
  27. Effects of Artemin on Nociceptors
    KATHRYN MARIE ALBERS; Fiscal Year: 2013
    ..We propose a mechanism by which Artn produces its effect that, if correct, may allow development of analgesic compounds that are effective in treating pain associated with chronic inflammatory disease. ..
  28. Pharmacological Diversity of nAChRs in Clade III Nematodes: Levamisole receptors
    RICHARD JOHN MARTIN; Fiscal Year: 2013
    ..The pharmacology of nematode nicotinic receptors (nAChRs) is more complex than has been appreciated...
  29. Mice with Functional Fluorescent Nicotinic Receptor Subunits
    Henry A Lester; Fiscal Year: 2010
    ..Other studies have linked one or both clusters with alcohol and cocaine dependence. Smoking is also clearly associated with chronic obstructive pulmonary disease. ..
  30. STUDIES USING PURIFIED ACETYLCHOLINE RECEPTORS
    JON MARTIN LINDSTROM; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVANCE: Nicotine acts through nicotinic receptors to cause addiction to tobacco, which results in more than 400,000 deaths/year in the United States...
  31. A lipid-based approach towards a high-resolution structure of a functional nAChR
    Jose Lasalde-Dominicci; Fiscal Year: 2013
    ..Thus, the proposed research is relevant to NIH's mission in that it will increase current knowledge about an important ligand-gated ion channel which could help extend healthy life and reduce the burdens of illness. ..
  32. Structural Mechanism of the Acetylcholine Receptor in Tubular Membrane Crystals
    PETER NIGEL UNWIN; Fiscal Year: 2013
    ..By understanding better the biological mechanisms of these receptors, we contribute basic insight into the nature of the disorders themselves. ..
  33. Nicotinic receptor genes & substance abuse: Functional studies of associated SNPs
    Jerry A Stitzel; Fiscal Year: 2010
    ..Finally, we will assess function of nicotinic receptors whose subunit constituents were generated using our in vitro system containing different alleles for ..
  34. Effects of nicotine and varenicline on ethanol behaviors
    Noah R Gubner; Fiscal Year: 2013
    ..This will provide a better understanding of how to use this drug in a clinical setting for the treatment of alcohol dependence. ..
  35. Nicotinic acetylcholine receptors and neuroblastoma
    Rae Nishi; Fiscal Year: 2012
    ..Based upon our expression data, we hypothesize that nicotinic receptors containing a5 contribute to the malignant phenotype of neuroblastoma and therefore may be a new target for ..
  36. Sex/Gender and Nicotine Addiction: Hormones, Behavior and Neuroimaging
    PERRY FRANKLIN RENSHAW; Fiscal Year: 2013
    ..The effects of IV nicotine and placebo nicotine on neuronal activity in brain areas with a high density of nicotinic receptors, and also in regions that may be important drug reward pathways will be measured over time, and correlated ..
  37. microRNA Regulation of the Nicotine Dependence Susceptibility Locus CHRNA5/A3/B4
    Paul D Gardner; Fiscal Year: 2013
    ..the order CHRNA5/A3/B4 relative to the centromere) and their products assemble to form a major subtype of nicotinic receptors expressed in the nervous system...
  38. Nicotine and the roles of nicotinic receptors in a rodent model of schizophrenia
    Russell W Brown; Fiscal Year: 2013
    ..four major findings: 1) Neonatal quinpirole treatment results in a significant increase in [unreadable]7 nicotinic receptors (nAChRs) in the striatum, a brain area important in drug reward;2) neonatal quinpirole treatment results in ..
  39. Alpha5 Subunits in Alpha4beta2 Nicotinic Receptors: Assembly and Function
    CRYSTAL N DILWORTH; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVANCE: Roughly 400,000 Americans and roughly 4,000,000 people worldwide die annually of the sequelae to nicotine dependence. This project attempts to explain nicotine dependence. ..
  40. Ethanol Regulation of Neuronal Nicotinic Receptor Expression in Reward Circuitry
    Andrew R Tapper; Fiscal Year: 2010
    ..The insights gained from this project should help elucidate the molecular mechanism underlying alcoholism, as well as identify molecular targets for alcohol cessation therapeutics. ..
  41. Role of alpha3-containing nicotinic receptors in mediating central nicotine effec
    Edward Hawrot; Fiscal Year: 2009
    ..Nicotine also significantly enhances cognitive performance, and some inherited forms of epilepsy involve nicotinic receptors. In addition, a loss of cholinergic neurons is implicated in Alzheimer's disease, a disorder currently ..
  42. Genetics of Nicotine Dependence
    Wade H Berrettini; Fiscal Year: 2013
    ..These binding proteins are involved in the development of nicotine addiction. Understanding the function consequences of these DNA variations will provide direction in developing new medications for nicotine addiction. ..
  43. Brain Imaging of Sex Differences in Tobacco Smokers
    Kelly P Cosgrove; Fiscal Year: 2010
    ..This will aid in the development of medications that are specifically designed to help both women and men quit smoking. ..
  44. Genetic Moderation of Attentional Deficits Resulting from Nicotine Withdrawal
    David E Evans; Fiscal Year: 2010
    ..This research may lead to practical applications, such as matching of individual genetic profiles and cognitive characteristics with appropriate behavioral and pharmacotherapy smoking cessation treatments. ..
  45. The rodent continuous performance task: Filling the vigilance translational gap
    JARED WILLIAM YOUNG; Fiscal Year: 2010
    ..This project will validate the novel rodent continuous performance test of vigilance, providing a means by which positive results for compounds observed in rodents will likely succeed in man. ..
  46. Novel, subtype selective potentiators of nicotinic acetycholine receptors
    MARVIN KENNETH SCHULTE; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Nicotinic receptors have been implicated in a broad range of neurological disorders including Alzheimer's disease (AD), Schizophrenia, Autism, Frontal Lobe Epilepsy, Parkinson's disease, ..
  47. Can drug targets from parasitic nematodes be usefully expressed in C. elegans?
    ADRIAN JOHN WOLSTENHOLME; Fiscal Year: 2013
    ..the anthelmintic sensitivity of transgenic worm strains;3) To directly record the properties of the muscle nicotinic receptors from transgenic strains expressing parasite nicotinic subunits...
  48. Nicotinic Acetylcholine Receptors and Inhibitory Behavior
    David J Bucci; Fiscal Year: 2013
    ..Together, these results of the proposed studies will provide new insight into how nicotine affects inhibitory behavior and promote the development of enhanced smoking cessation and treatment regimens. ..
  49. Dissecting the Cytoplasmic Interactome of the Alpha7 nACHR Subtype
    WILLIAM J BRUCKER; Fiscal Year: 2013
    ..The interactome data gathered from the nicotine exposed mice will be compared to the unexposed mice to determine if any difference exists. ..
  50. Cholinergic receptors on the nematode pharynx: an unexploited drug target
    Alan P Robertson; Fiscal Year: 2012
    ..The longer term goal of this research is provide ion- channel drug targets from a range of important parasite species in a platform (Xenopus oocytes) suitable for drug discovery screening. ..
  51. In-Utero Smoke, Vitamin C and Newborn Lung Function
    CYNTHIA T MCEVOY; Fiscal Year: 2010
    ..We hypothesize that nicotine interacts with nicotinic receptors in the developing lung, causing altered growth and pulmonary function...
  52. Analysis of nicotinic acetylcholine receptor function in C. elegans
    Michael M Francis; Fiscal Year: 2013
    ..Moreover, nicotine binding to nicotinic receptors in the nervous system initiates the cellular and molecular cascade that results in nicotine addiction...
  53. Anesthetic Sites in Transmembrance Peptides by NMR
    Pei Tang; Fiscal Year: 2012
    ..The research will eventually lead to better design of safer and more effective new anesthetic drugs. ..
  54. Expression and Function of the Alpha 7 Nicotinic Receptor in Schizophrenia
    Sherry Leonard; Fiscal Year: 2013
    ..b>Nicotinic receptors are involved in both schizophrenia and smoking...
  55. Alpha 5 Nicotinic Receptor Subunit Gene Polymorphisms and Smoking Addiction
    Alexey G Mukhin; Fiscal Year: 2013
    ..g., mandated reductions in tobacco nicotine content, currently being considered by FDA. The results can also provide justification for developing new treatments targeting nicotinic receptors containing the a5 subunit.
  56. Interventions to Test the alpha 7 Nicotinic Receptor Model in Schizophrenia
    Stephen Deutsch; Fiscal Year: 2009
    ..If the results of this pilot trial are positive, the next steps will be a definitive trial and efforts to develop medications that combine the allosteric modulatory and agonist properties of the combination in a single molecule. ..
  57. Modulation of levamisole receptors: Pharmacological Diversity of Clade III nAChRs
    RICHARD JOHN MARTIN; Fiscal Year: 2011
    ..The pharmacology of nematode nicotinic receptors (nAChRs) is more complex than has been appreciated...
  58. Varenicline Treatment for Active Alcholic Smokers
    Richard D Hurt; Fiscal Year: 2012
    ..If successful, this will be an important step forward in treating alcoholic smokers and will result in lives saved by reducing tobacco-caused deaths in this high risk population. ..
  59. Maternal smoking and hippocampal circuits
    Katumi Sumikawa; Fiscal Year: 2010
    ....
  60. Nicotinic Acetylcholine Receptor Mediated Bitter Taste Transduction
    Vijay Lyall; Fiscal Year: 2013
    ..The effects of cigarette smoking on food consumption and taste preferences may occur from peripheral taste modulation due to chronic exposure to nicotine acting on nAChRs in taste buds among other factors. ..
  61. Role of Habenula in Tobacco Addiction
    Ramiro Salas; Fiscal Year: 2013
    ..I had a postdoctoral experience in which I worked on mice with mutations on nicotinic receptors (nAChR), using behavior, in vivo pharmacology, microdialysis, etc...
  62. High Throughput Screening for nAChRs: Cell Lines and Assay Development
    Yingxian Xiao; Fiscal Year: 2011
    ..Selective ligands of nicotinic receptors can be used in studying nicotine addiction and for developing new smoking cessation therapeutics...
  63. NEUROPEPTIDE Y MODULATION OF ADRENOMEDULLARY SECRETION
    TERRY HEXUM; Fiscal Year: 1993
    ..the presence of various nicotinic agonists, it's action on agents stimulating secretion through other than nicotinic receptors and the effect of truncated forms of NPY and peptides possessing sequence homologies with NPY...
  64. The Cholinergic Anti-Inflammatory Pathway in Human Obesity and Insulin Resistance
    Karen Teff; Fiscal Year: 2009
    ..Positive findings would support future investigations for the development of a new therapeutic target to lower cytokine levels in obese individuals. ..
  65. In vivo and in vitro tools to target CHRNA5 for smoking cessation.
    Andreas Walz; Fiscal Year: 2011
    ..in eliciting the reward signal in the brain, or by interfering with receptors, such as dopaminergic or nicotinic receptors expressed in the dopaminergic pathway...
  66. Diversity of Nicotinic Synapses in Sympathetic Ganglia
    John Horn; Fiscal Year: 2004
    The long-term goal of this project is to determine how diversity in the cellular expression of neuronal nicotinic receptors contributes to synaptic function in mammalian sympathetic ganglia...
  67. PRE & POSTSYNAPTIC NICOTINIC ACHRS--STRUCTURE & FUNCTION
    Peter Sargent; Fiscal Year: 1999
    ..We will pay particular attention to presynaptic nicotinic receptors, which, although virtually uncharacterized to date, may represent the predominant form of nAChR in the ..
  68. GENETIC LINKAGE OF AUDITORY GATING
    Karen Stevens; Fiscal Year: 2001
    ..Such information could be important in understanding of the etiology of the disorder and in determining future therapeutic interventions. ..
  69. Nicotine Addiction: ACh Receptors and Secretion
    Aaron Fox; Fiscal Year: 2002
    ..is not understood there is a growing body of evidence pointing to the involvement of high-affinity neuronal nicotinic receptors (nAChR) in addiction. Our project will explore possible mechanisms that underlie nicotine addiction...
  70. NICOTINIC RECEPTOR SITES FOR ALCOHOL ACTIONS
    Stuart Forman; Fiscal Year: 2000
    ..While there is both pharmacologic and physiologic data to implicate neuronal nicotinic receptors in ethanol-induced intoxication and addictive behavior, far more is known about the actions of alcohols at ..
  71. Beta Amyloid and Presynaptic Nicotinic Receptors
    Robert Nichols; Fiscal Year: 2007
    ..Indeed, beta amyloid has recently been shown to interact directly with nicotinic receptors on neuronal cell bodies...
  72. FUNCTIONAL ACTIVITY OF MESOLIMBIC NICOTINIC RECEPTORS
    PETER ROWELL; Fiscal Year: 2001
    ..Studies of nicotinic receptors in other brain areas or in peripheral nerves have shown that, while brief exposure to nicotine produces ..
  73. Pharmacology and Regulation of Nicotinic Receptor Subtypes
    Kenneth Kellar; Fiscal Year: 2007
    ..b>Nicotinic receptors are also crucial for normal functioning of the autonomic nervous system, and thus they influence virtually ..
  74. Nicotinic Receptors in Cochlear Hair Cell Physiology
    Paul Fuchs; Fiscal Year: 2005
    ..This research will be done primarily in Argentina at INGEBI (National Research Council) in collaboration with Ana Belen Elgoyhen as an extension of NIH grant #R01 DC01508. ..