glutamate receptors

Summary

Summary: Cell-surface proteins that bind glutamate and trigger changes which influence the behavior of cells. Glutamate receptors include ionotropic receptors (AMPA, kainate, and N-methyl-D-aspartate receptors), which directly control ion channels, and metabotropic receptors which act through second messenger systems. Glutamate receptors are the most common mediators of fast excitatory synaptic transmission in the central nervous system. They have also been implicated in the mechanisms of memory and of many diseases.

Top Publications

  1. ncbi The number of glutamate receptors opened by synaptic stimulation in single hippocampal spines
    Esther A Nimchinsky
    Howard Hughes Medical Institute, The Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
    J Neurosci 24:2054-64. 2004
  2. pmc Variant ionotropic glutamate receptors as chemosensory receptors in Drosophila
    Richard Benton
    Laboratory of Neurogenetics and Behavior, The Rockefeller University, 1230 York Avenue, Box 63, New York, NY 10065, USA
    Cell 136:149-62. 2009
  3. ncbi Glutamate receptors, neurotoxicity and neurodegeneration
    Anthony Lau
    Division of Applied and Interventional Research, Toronto Western Research Institute, 399 Bathurst Street, Toronto, ON, Canada, M5T 2S8
    Pflugers Arch 460:525-42. 2010
  4. ncbi Synaptic development: insights from Drosophila
    Catherine A Collins
    Department of Molecular Biology and Pharmacology, Campus Box 8103, 660 South Euclid, Washington University School of Medicine, St Louis, MO 63110, USA
    Curr Opin Neurobiol 17:35-42. 2007
  5. pmc Diabetes changes the levels of ionotropic glutamate receptors in the rat retina
    Ana R Santiago
    Department of Zoology, University of Coimbra, Center for Neuroscience and Cell Biology, Coimbra, Portugal
    Mol Vis 15:1620-30. 2009
  6. ncbi Presynaptic glutamate receptors: physiological functions and mechanisms of action
    Paulo S Pinheiro
    Laboratoire Physiologie Cellulaire de la Synapse, Centre National de la Recherche Scientifique Unite mixte de recherche 5091, Bordeaux Neuroscience Institute, University of Bordeaux, 33077 Bordeaux, France
    Nat Rev Neurosci 9:423-36. 2008
  7. ncbi Control of dorsal raphe serotonergic neurons by the medial prefrontal cortex: Involvement of serotonin-1A, GABA(A), and glutamate receptors
    P Celada
    Department of Neurochemistry, , , 08036 Barcelona, Spain
    J Neurosci 21:9917-29. 2001
  8. ncbi Amyloid beta oligomers induce Ca2+ dysregulation and neuronal death through activation of ionotropic glutamate receptors
    Elena Alberdi
    Centro de Investigación Biomédica en Red en Enfermedades Neurodegenerativas CIBERNED, Departamento de Neurociencias, Universidad del Pais Vasco, E 48940 Leioa, Spain
    Cell Calcium 47:264-72. 2010
  9. ncbi Expression of glutamate receptors and calcium-binding proteins in the retina of streptozotocin-induced diabetic rats
    Yee Kong Ng
    Department of Anatomy, Faculty of Medicine, National University of Singapore, MD10, 4 Medical Drive, Singapore 117597, Singapore
    Brain Res 1018:66-72. 2004
  10. ncbi Brain-derived neurotrophic factor but not forced arm use improves long-term outcome after photothrombotic stroke and transiently upregulates binding densities of excitatory glutamate receptors in the rat brain
    Harald D Müller
    Department of Neuropathology, Johannes Gutenberg University of Mainz, Mainz, Germany
    Stroke 39:1012-21. 2008

Research Grants

Detail Information

Publications323 found, 100 shown here

  1. ncbi The number of glutamate receptors opened by synaptic stimulation in single hippocampal spines
    Esther A Nimchinsky
    Howard Hughes Medical Institute, The Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
    J Neurosci 24:2054-64. 2004
    ..Our measurements further demonstrate that optical recordings can be used to study single receptors in intact systems...
  2. pmc Variant ionotropic glutamate receptors as chemosensory receptors in Drosophila
    Richard Benton
    Laboratory of Neurogenetics and Behavior, The Rockefeller University, 1230 York Avenue, Box 63, New York, NY 10065, USA
    Cell 136:149-62. 2009
    Ionotropic glutamate receptors (iGluRs) mediate neuronal communication at synapses throughout vertebrate and invertebrate nervous systems...
  3. ncbi Glutamate receptors, neurotoxicity and neurodegeneration
    Anthony Lau
    Division of Applied and Interventional Research, Toronto Western Research Institute, 399 Bathurst Street, Toronto, ON, Canada, M5T 2S8
    Pflugers Arch 460:525-42. 2010
    ..review addresses the current state of excitotoxic research, focusing on the structure and physiology of glutamate receptors; molecular mechanisms underlying excitotoxic cell death pathways and their interactions with each other; ..
  4. ncbi Synaptic development: insights from Drosophila
    Catherine A Collins
    Department of Molecular Biology and Pharmacology, Campus Box 8103, 660 South Euclid, Washington University School of Medicine, St Louis, MO 63110, USA
    Curr Opin Neurobiol 17:35-42. 2007
    ....
  5. pmc Diabetes changes the levels of ionotropic glutamate receptors in the rat retina
    Ana R Santiago
    Department of Zoology, University of Coimbra, Center for Neuroscience and Cell Biology, Coimbra, Portugal
    Mol Vis 15:1620-30. 2009
    ..The purpose of this study was to investigate whether diabetes leads to changes in ionotropic glutamate receptor subunit expression at the protein and mRNA level in the rat retina...
  6. ncbi Presynaptic glutamate receptors: physiological functions and mechanisms of action
    Paulo S Pinheiro
    Laboratoire Physiologie Cellulaire de la Synapse, Centre National de la Recherche Scientifique Unite mixte de recherche 5091, Bordeaux Neuroscience Institute, University of Bordeaux, 33077 Bordeaux, France
    Nat Rev Neurosci 9:423-36. 2008
    Glutamate acts on postsynaptic glutamate receptors to mediate excitatory communication between neurons...
  7. ncbi Control of dorsal raphe serotonergic neurons by the medial prefrontal cortex: Involvement of serotonin-1A, GABA(A), and glutamate receptors
    P Celada
    Department of Neurochemistry, , , 08036 Barcelona, Spain
    J Neurosci 21:9917-29. 2001
    ..Afferents from the mPFC also inhibit 5-HT neurons through the activation of GABAergic interneurons. Ascending serotonergic pathways may control the activity of this descending pathway by acting on postsynaptic 5-HT(1A) receptors...
  8. ncbi Amyloid beta oligomers induce Ca2+ dysregulation and neuronal death through activation of ionotropic glutamate receptors
    Elena Alberdi
    Centro de Investigación Biomédica en Red en Enfermedades Neurodegenerativas CIBERNED, Departamento de Neurociencias, Universidad del Pais Vasco, E 48940 Leioa, Spain
    Cell Calcium 47:264-72. 2010
    ..In this study, we investigated the role of ionotropic glutamate receptors on the intracellular Ca2+ overload caused by Abeta...
  9. ncbi Expression of glutamate receptors and calcium-binding proteins in the retina of streptozotocin-induced diabetic rats
    Yee Kong Ng
    Department of Anatomy, Faculty of Medicine, National University of Singapore, MD10, 4 Medical Drive, Singapore 117597, Singapore
    Brain Res 1018:66-72. 2004
    This study was aimed to investigate the expression of glutamate receptors and calcium-binding proteins in 1- and 4-month/s (mo) streptozotocin (STZ)-induced diabetic rats...
  10. ncbi Brain-derived neurotrophic factor but not forced arm use improves long-term outcome after photothrombotic stroke and transiently upregulates binding densities of excitatory glutamate receptors in the rat brain
    Harald D Müller
    Department of Neuropathology, Johannes Gutenberg University of Mainz, Mainz, Germany
    Stroke 39:1012-21. 2008
    ..The aim of the present study was to check whether postischemic long-term outcome correlates to specific modifications in the abundance of various neurotransmitter receptors...
  11. ncbi Glutamate receptors in perirhinal cortex mediate encoding, retrieval, and consolidation of object recognition memory
    Boyer D Winters
    Department of Experimental Psychology, University of Cambridge, Cambridge CB2 3EB, United Kingdom
    J Neurosci 25:4243-51. 2005
    ....
  12. ncbi A family of metabotropic glutamate receptors
    Y Tanabe
    Institute for Immunology, Kyoto University Faculty of Medicine, Japan
    Neuron 8:169-79. 1992
    ..The mGluRs thus form a novel family of G protein-coupled receptors that differ in their signal transduction and expression patterns...
  13. ncbi Impairment of motor coordination, Purkinje cell synapse formation, and cerebellar long-term depression in GluR delta 2 mutant mice
    N Kashiwabuchi
    Department of Neuropharmacology, Niigata University, Japan
    Cell 81:245-52. 1995
    ..These results suggest a close relationship between synaptic plasticity and synapse formation in the cerebellum...
  14. ncbi Synaptic trafficking of glutamate receptors by MAGUK scaffolding proteins
    Guillermo M Elias
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94143, USA
    Trends Cell Biol 17:343-52. 2007
    ..The trafficking of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA)-type glutamate receptors to and from these synapses controls the strength of excitatory synaptic transmission...
  15. pmc CPG2: a brain- and synapse-specific protein that regulates the endocytosis of glutamate receptors
    Jeffrey R Cottrell
    The Picower Center for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Neuron 44:677-90. 2004
    ..b>Glutamate receptors are constitutively and acutely internalized, presumptively through clathrin-mediated receptor endocytosis...
  16. ncbi Glutamate receptors on dopamine neurons control the persistence of cocaine seeking
    David Engblom
    Division of Molecular Biology of the Cell I, German Cancer Research Center, 69120 Heidelberg, Germany
    Neuron 59:497-508. 2008
    ..In conclusion, cocaine-evoked synaptic plasticity does not mediate concurrent short-term behavioral effects of the drug but may initiate adaptive changes eventually leading to the persistence of drug-seeking behavior...
  17. ncbi Targeting of PKA to glutamate receptors through a MAGUK-AKAP complex
    M Colledge
    Howard Hughes Medical Institute, Vollum Institute, Oregon Health Sciences University, Portland 97201, USA
    Neuron 27:107-19. 2000
    Compartmentalization of glutamate receptors with the signaling enzymes that regulate their activity supports synaptic transmission...
  18. ncbi Glutamate receptors on human melanocytes regulate the expression of MiTF
    M J Hoogduijn
    Biomedical Tissue Research Group, Department of Biology, University of York, York YO10 5YW, UK
    Pigment Cell Res 19:58-67. 2006
    ..The present study examined the expression and functionality of metabotropic and ionotropic glutamate receptors on normal human melanocytes...
  19. ncbi Preferential localization of glutamate receptors opposite sites of high presynaptic release
    Scott B Marrus
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, MO 63110 USA
    Curr Biol 14:924-31. 2004
    The localization of glutamate receptors is essential for the formation and plasticity of excitatory synapses...
  20. ncbi Molecular and immunochemical characterization of the ionotropic glutamate receptors in the rat heart
    S S Gill
    Toxicology Research Division, Bureau Chemical Safety, Health Protection Branch, Ottawa, Ontario, Canada
    Brain Res Bull 46:429-34. 1998
    Excitatory amino acids (EAA) and glutamate receptors (GluRs) play a fundamental role in the central nervous system (CNS)...
  21. ncbi The extreme C-terminus of GluRdelta2 is essential for induction of long-term depression in cerebellar slices
    Kazuhisa Kohda
    Department of Physiology, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Eur J Neurosci 25:1357-62. 2007
    ..Together, these results indicate that PDZ proteins that bind to the C-terminus of GluRdelta2 are not essential for localizing GluRdelta2 at synapses but are crucial for conveying signals necessary for the induction of LTD...
  22. ncbi Structure-stability-function relationships of dendritic spines
    Haruo Kasai
    Department of Cell Physiology, National Institute for Physiological Sciences and The Graduate University for Advanced Studies SOKENDAI, Okazaki 444 8585, Japan
    Trends Neurosci 26:360-8. 2003
    ..Spines with large heads are stable, express large numbers of AMPA-type glutamate receptors, and contribute to strong synaptic connections...
  23. ncbi Glutamate receptors in pediatric tumors of the central nervous system
    Katja S Brocke
    Department of Pediatric Neurology, University Hospital Carl Gustav Carus, Children s Hospital, University of Technology Dresden, Dresden, Germany
    Cancer Biol Ther 9:455-68. 2010
    ....
  24. ncbi Neurodegeneration in Lurcher mice caused by mutation in delta2 glutamate receptor gene
    J Zuo
    Laboratory of Molecular Biology, Howard Hughes Medical Institute, The Rockefeller University, New York, New York 10021, USA
    Nature 388:769-73. 1997
    ..Thus the activation of apoptotic neuronal death in Lurcher mice may provide a physiologically relevant model for excitotoxic cell death...
  25. ncbi The effects of copper ions on glutamate receptors in cultured rat cortical neurons
    T Weiser
    Department of Biological Research, Boehringer Ingelheim KG, Germany
    Brain Res 742:211-8. 1996
    ..In this study, we used the patch-clamp technique to investigate the effect of copper ions on glutamate receptors in cultured rat cortical neurons...
  26. ncbi Glutamate signalling in non-neuronal tissues
    T M Skerry
    Dept of Biology, University of York, PO Box 373, YO10 5YW, UK
    Trends Pharmacol Sci 22:174-81. 2001
    ..Agents developed for use in neuroscience applications might be beneficial in the modulation of pathology peripherally, impacting on conditions such as osteoporosis, diabetes and wound healing...
  27. ncbi Functional remodeling of glutamate receptors by inner retinal neurons occurs from an early stage of retinal degeneration
    Jacqueline Chua
    Department of Optometry and Vision Science, University of Auckland, Private Bag 92010, Auckland, New Zealand
    J Comp Neurol 514:473-91. 2009
    ..modified glutamate receptor disposition and altered responses secondary to functional activation of glutamate receptors. We investigated the neurochemical remodeling of retinal neurons in the rd/rd (rd1) mouse retina by ..
  28. ncbi Roles of glutamate receptors and the mammalian target of rapamycin (mTOR) signaling pathway in activity-dependent dendritic protein synthesis in hippocampal neurons
    Ruomu Gong
    Department of Neurobiology and Behavior, Center for Neurobiology of Learning and Memory, University of California, Irvine, California 92697 3800, USA
    J Biol Chem 281:18802-15. 2006
    ..The purpose of this study is to determine the role of glutamate receptors and the mammalian target of rapamycin (mTOR) signaling in regulating dendritic protein synthesis in live ..
  29. ncbi Functional compartmentalization of endosomal trafficking for the synaptic delivery of AMPA receptors during long-term potentiation
    Tyler C Brown
    Neuroscience Program and Department of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    J Neurosci 27:13311-5. 2007
    ..Here we report that the transport of AMPA-type glutamate receptors into synapses occurs in two discrete steps, and we identify the specific endosomal functions that control ..
  30. ncbi Glutamate receptor exocytosis and spine enlargement during chemically induced long-term potentiation
    Charles D Kopec
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
    J Neurosci 26:2000-9. 2006
    ..Here, we use a pH-sensitive green fluorescent protein to tag recombinant glutamate receptors and monitor their dynamics onto dendritic spine surfaces...
  31. ncbi Reversibly caged glutamate: a photochromic agonist of ionotropic glutamate receptors
    Matthew Volgraf
    Department of Chemistry, University of California, Berkeley, California 94720, USA
    J Am Chem Soc 129:260-1. 2007
  32. ncbi Impaired parallel fiber-->Purkinje cell synapse stabilization during cerebellar development of mutant mice lacking the glutamate receptor delta2 subunit
    H Kurihara
    Department of Anatomy, Hokkaido University School of Medicine, Sapporo 060, Japan
    J Neurosci 17:9613-23. 1997
    ....
  33. pmc Allosteric control of an ionotropic glutamate receptor with an optical switch
    Matthew Volgraf
    Department of Chemistry, University of California, Berkeley, California 94720, USA
    Nat Chem Biol 2:47-52. 2006
    ..Our device has potential uses not only in biology but also in bioelectronics and nanotechnology...
  34. ncbi Neurological dysfunctions in mice expressing different levels of the Q/R site-unedited AMPAR subunit GluR-B
    D Feldmeyer
    Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Heidelberg, Germany
    Nat Neurosci 2:57-64. 1999
    ..Thus, changes in GluR-B gene expression and Q/R site editing can affect critical architectural and functional aspects of excitatory principal neurons...
  35. pmc Unc-51 controls active zone density and protein composition by downregulating ERK signaling
    Yogesh P Wairkar
    Department of Developmental Biology, Washington University, St Louis, Missouri 63110, USA
    J Neurosci 29:517-28. 2009
    ..the presynaptic motoneuron to regulate the localization of the active zone protein Bruchpilot opposite to glutamate receptors at each synapse...
  36. ncbi The role of amygdala glutamate receptors in fear learning, fear-potentiated startle, and extinction
    David L Walker
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Woodruff Memorial Building, 1639 Pierce Drive, Suite 4000, Atlanta, GA 30322, USA
    Pharmacol Biochem Behav 71:379-92. 2002
    ..A fuller understanding of the role of amygdala glutamate systems in fear and fear learning may suggest novel pharmacological approaches to the treatment of clinical anxiety disorders...
  37. ncbi Independent regulation of synaptic size and activity by the anaphase-promoting complex
    Peter van Roessel
    Wellcome Trust Cancer Research UK Gurdon Institute and Department of Anatomy, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, United Kingdom
    Cell 119:707-18. 2004
    ..In neurons, the APC/C controls synaptic size via a downstream effector Liprin-alpha; in muscles, the APC/C regulates synaptic transmission, controlling the concentration of a postsynaptic glutamate receptor...
  38. doi Beta-amyloid and glutamate receptors
    Laura Gasparini
    Department of Neuroscience and Brain Technologies, The Italian Institute of Technology, 16163 Genova, Italy
    Exp Neurol 212:1-4. 2008
  39. ncbi Selective expression of the glutamate receptor channel delta 2 subunit in cerebellar Purkinje cells
    K Araki
    Department of Neuropharmacology, Niigata University, Japan
    Biochem Biophys Res Commun 197:1267-76. 1993
    ..The selective localization of the delta 2 subunit in Purkinje cells may imply a role of the delta 2 subunit in Purkinje cell-specific function such as the cerebellar LTD...
  40. ncbi Mice with genetically altered glutamate receptors as models of schizophrenia: a comprehensive review
    Dragos Inta
    Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, J5, 68159 Mannheim, Germany
    Neurosci Biobehav Rev 34:285-94. 2010
    Recent clinical evidence for the effectiveness of new antipsychotic drugs that specifically target glutamate receptors has rekindled interest in the glutamatergic system regarding pathophysiology and treatment of schizophrenia...
  41. pmc Glutamate receptors in neuroinflammatory demyelinating disease
    Christopher Bolton
    Centre for Biochemical Pharmacology and Experimental Pathology, John Vane Science Centre, St Bartholomew s Hospital Medical School, Charterhouse Square, London EC1M 6BQ, UK
    Mediators Inflamm 2006:93684. 2006
    ..N-methyl-D-aspartate (NMDA) and alpha-amino-3-hydroxy-5-isoxazolepropionic acid (AMPA)/kainate family of glutamate receptors reported to control neurovascular permeability, inflammatory mediator synthesis, and resident glial cell ..
  42. ncbi Spontaneous synchronized calcium oscillations in neocortical neurons in the presence of physiological [Mg(2+)]: involvement of AMPA/kainate and metabotropic glutamate receptors
    Shashank M Dravid
    Department of Physiology and Pharmacology, College of Veterinary Medicine, The University of Georgia, Athens, GA 30602, USA
    Brain Res 1006:8-17. 2004
    ....
  43. pmc Dynamics of learning in cultured neuronal networks with antagonists of glutamate receptors
    Yanling Li
    The Key Laboratory of Biomedical Photonics, Huazhong University of Science and Technology, Wuhan, People s Republic of China
    Biophys J 93:4151-8. 2007
    Cognitive dysfunction may result from abnormality of ionotropic glutamate receptors. Although various forms of synaptic plasticity in learning that rely on altering of glutamate receptors have been considered, the evidence is ..
  44. ncbi Emerging evidence for a similar role of glutamate receptors in the nervous and immune systems
    Alexander A Boldyrev
    Center for Molecular Medicine and International Biotechnological Center Department of Biochemistry, M V Lomonosov Moscow State University, Moscow, Russia
    J Neurochem 95:913-8. 2005
    The role of glutamate receptors in synaptic transmission and excitotoxicity in the nervous system is well established. Recent evidence has emerged that glutamatergic mechanisms also exist in a wide variety of non-neuronal cells...
  45. ncbi ERKs regulate PKC-dependent synaptic depression and declustering of glutamate receptors in cerebellar Purkinje cells
    Shogo Endo
    Neuronal Circuit Mechanisms Research Group, RIKEN Brain Science Institute, Wako 351 0198, Japan
    Neuropharmacology 45:863-72. 2003
    ..These results suggest that ERK1/2 plays an essential role in TPA-induced depression via regulation of GluR2/3 declustering at the synapse...
  46. ncbi Aberrant formation of glutamate receptor complexes in hippocampal neurons of mice lacking the GluR2 AMPA receptor subunit
    Nathalie Sans
    Laboratory of Neurochemistry, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, Maryland 20892 8027, USA
    J Neurosci 23:9367-73. 2003
    ..Therefore, GluR1 may have a greater preference for GluR2 than it does for GluR3...
  47. ncbi Flip and flop: a cell-specific functional switch in glutamate-operated channels of the CNS
    B Sommer
    Laboratory of Molecular Neuroendocrinology, Center for Molecular Biology, University of Heidelberg, F R G
    Science 249:1580-5. 1990
    ..These results identify a switch in the molecular and functional properties of glutamate receptors operated by alternative splicing.
  48. ncbi Neural activity affects distribution of glutamate receptors during neuromuscular junction formation in Drosophila embryos
    M Saitoe
    Institute for Behavioral Sciences, Gunma University School of Medicine, Showa machi, Maebashi, Japan
    Dev Biol 184:48-60. 1997
    ..We raised antibodies against Drosophila glutamate receptors (DGluR-II) and visualized the distribution of receptors during neuromuscular junction formation in embryos...
  49. pmc Glutamate receptors in plants
    Romola Davenport
    Department of Plant Science, Downing Street, Cambridge CB2 3EA, UK
    Ann Bot 90:549-57. 2002
    Ionotropic glutamate receptors function in animals as glutamate-gated non-selective cation channels...
  50. ncbi Kanamycin reveals the role played by glutamate receptors in shaping plant resource allocation
    Christian Dubos
    Department of Plant Sciences, University of Oxford, South Parks Road, Oxford OX1 3RB, UK
    Plant J 43:348-55. 2005
    Ionotropic glutamate receptors (iGluRs) play important roles in neurotransmission in animals. There is growing evidence that iGluRs also play important roles in plants...
  51. ncbi Analysis of synaptic ultrastructure without fixative using high-pressure freezing and tomography
    Philippe Rostaing
    INSERM U789, Ecole Normale Superieure, 46 rue d Ulm, 75005 Paris, France
    Eur J Neurosci 24:3463-74. 2006
    ..Particularly, filamentous projections were observed linking the PSD to the actin cytoskeleton. Thus, synaptic ultrastructure can be analysed under more realistic conditions following HPF...
  52. ncbi Chronic blockade of glutamate receptors enhances presynaptic release and downregulates the interaction between synaptophysin-synaptobrevin-vesicle-associated membrane protein 2
    A Bacci
    Consiglio Nazionale delle Ricerche, Cellular and Molecular Pharmacology and B. Ceccarelli Centers, Department of Medical Pharmacology, University of Milan, 20129 Milan, Italy
    J Neurosci 21:6588-96. 2001
    ..We have investigated whether activation of glutamate receptors affects presynaptic function during synapse formation, when constitutive synaptic vesicle recycling is ..
  53. ncbi Functional interactions between somatodendritic dopamine release, glutamate receptors and brain-derived neurotrophic factor expression in mesencephalic structures of the brain
    Gonzalo Bustos
    Laboratory of Biochemical Pharmacology, Department of Cell and Molecular Biology, Catholic University of Chile, Alameda 340, Santiago 114 D, Chile
    Brain Res Brain Res Rev 47:126-44. 2004
    ..DA release via activation of NMDA-receptors (NMDA-Rs) and to a lesser extent through group II metabotropic glutamate receptors (mGluRs)...
  54. ncbi Glutamate receptors at bipolar synapses in the inner plexiform layer of primate retina: light microscopic analysis
    Ulrike Grünert
    Department of Physiology F13 and Institute for Biomedical Research, The University of Sydney, NSW 2006, Australia
    J Comp Neurol 466:136-47. 2003
    ..we investigated whether different types of bipolar cells are associated with different types of ionotropic glutamate receptors in the inner retina of a New World primate, the common marmoset Callithrix jacchus...
  55. pmc Glutamate receptors as therapeutic targets for Parkinson's disease
    Kari A Johnson
    Department of Pharmacology, Vanderbilt University, Nashville, TN, USA
    CNS Neurol Disord Drug Targets 8:475-91. 2009
    ..The ability of ionotropic and metabotropic glutamate receptors to modulate neurotransmission throughout the basal ganglia suggests that these receptors may be targets for ..
  56. ncbi Dissociation between rewarding and psychomotor effects of opiates: differential roles for glutamate receptors within anterior and posterior portions of the ventral tegmental area
    Maytal Shabat-Simon
    Department of Neurobiology, The Weizmann Institute of Science, Rehovot 76100, Israel
    J Neurosci 28:8406-16. 2008
    ..We explored whether blockade of glutamate receptors in subregions of the VTA modulate the rewarding properties and/or the development of psychomotor changes ..
  57. ncbi Stretch-induced injury in organotypic hippocampal slice cultures reproduces in vivo post-traumatic neurodegeneration: role of glutamate receptors and voltage-dependent calcium channels
    Heather L Cater
    Division of Clinical Neurosciences, University of Southampton, Southampton, UK
    J Neurochem 101:434-47. 2007
    ....
  58. ncbi Glutamate receptors in the rod pathway of the mammalian retina
    K K Ghosh
    , Neuroanatomie, D-60528 Frankfurt, Germany
    J Neurosci 21:8636-47. 2001
    ..We examined the glutamate receptors (GluRs) that are expressed by AI and AII cells using immunocytochemistry with specific antibodies against ..
  59. pmc Left-right asymmetry of the hippocampal synapses with differential subunit allocation of glutamate receptors
    Yoshiaki Shinohara
    Division of Cerebral Structure, National Institute for Physiological Sciences, Okazaki 444 8787, Japan
    Proc Natl Acad Sci U S A 105:19498-503. 2008
    ..Our study demonstrates universal left-right asymmetry of hippocampal synapses with a fundamental relationship between synaptic area and the expression of glutamate receptor subunits...
  60. ncbi The influence of various glutamate receptors antagonists on anxiety-like effect of ethanol withdrawal in a plus-maze test in rats
    Jolanta Kotlinska
    Department of Pharmacology and Pharmacodynamics, Medical University School, Lublin, Poland
    Eur J Pharmacol 598:57-63. 2008
    ....
  61. ncbi Ionotropic glutamate receptors in spinal nociceptive processing
    Max Larsson
    Department of Anatomy and Centre for Molecular Biology and Neuroscience, University of Oslo, Norway
    Mol Neurobiol 40:260-88. 2009
    ..Accordingly, ionotropic glutamate receptors mediate basal spinal transmission of sensory, including nociceptive, information that is relayed to ..
  62. ncbi Calcium-permeable glutamate receptors in horizontal cells of the mammalian retina
    L Rivera
    , Facultad de Farmacia, Universidad de Complutense, Madrid, Spain
    Vis Neurosci 18:995-1002. 2001
    ..AMPA-preferring glutamate receptors were shown to permeate Ca2+ in mammalian HCs by ionic substitution experiments...
  63. ncbi Prolonged blockade of NMDA or mGluR5 glutamate receptors reduces nigrostriatal degeneration while inducing selective metabolic changes in the basal ganglia circuitry in a rodent model of Parkinson's disease
    Marie Therese Armentero
    Laboratory of Functional Neurochemistry, IRCCS Neurological Institute C Mondino, Via Mondino, 2, 27100 Pavia, Italy
    Neurobiol Dis 22:1-9. 2006
    ..Specific modulation of STN hyperactivity obtained with mGluR5 blockade may, therefore, open interesting perspectives for the use of this class of compounds in the treatment of Parkinson's disease...
  64. pmc Control of assembly and function of glutamate receptors by the amino-terminal domain
    Kasper B Hansen
    Department of Pharmacology, Emory University School of Medicine, Rollins Research Center, 1510 Clifton Road, Atlanta, GA 30322 3090, USA
    Mol Pharmacol 78:535-49. 2010
    ..domains (ATDs) of the ionotropic glutamate receptor subunits form a semiautonomous component of all glutamate receptors that resides distal to the membrane and controls a surprisingly diverse set of receptor functions...
  65. ncbi Glutamate receptors: brain function and signal transduction
    S Nakanishi
    Department of Biological Sciences, Kyoto University Faculty of Medicine, Yoshida, Sakyo ku, Kyoto 606, Japan
    Brain Res Brain Res Rev 26:230-5. 1998
    b>Glutamate receptors are important in neural plasticity, neural development and neurodegeneration...
  66. ncbi Mature myelin basic protein-expressing oligodendrocytes are insensitive to kainate toxicity
    Paul A Rosenberg
    Department of Neurology and Program in Neuroscience, Children s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci Res 71:237-45. 2003
    ..subunits (GluR) -2, -4, -6, -7, and KA2 using immunoblot analysis and found that expression of all of these glutamate receptors was significantly down-regulated in mature oligodendrocytes...
  67. pmc Nanosculpting reversed wavelength sensitivity into a photoswitchable iGluR
    Rika Numano
    Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 106:6814-9. 2009
    ..The ability to generate opposite responses with a single PTL and 2 versions of a target channel, which can be expressed in different cell types, paves the way for engineering opponency in neurons that mediate opposing functions...
  68. ncbi Combined blockade of AMPA and NMDA glutamate receptors reduces levodopa-induced motor complications in animal models of PD
    F Bibbiani
    ETB, NINDS, National Institutes of Health, Bethesda, MD 20892, USA
    Exp Neurol 196:422-9. 2005
    ..The results suggest that mechanisms mediated by both ionotropic glutamate receptors make an independent contribution to the pathogenesis of these motor response changes and further that a ..
  69. ncbi Pedunculopontine tegmental stimulation evokes striatal dopamine efflux by activation of acetylcholine and glutamate receptors in the midbrain and pons of the rat
    Gina L Forster
    Department of Psychology, Macquarie University, Sydney, NSW 2109, Australia
    Eur J Neurosci 17:751-62. 2003
    ..These results suggest that the pedunculopontine tegmental nucleus utilizes nicotinic and ionotropic glutamate receptors in the substantia nigra to mediate rapid activation, M2-like muscarinic autoreceptors in the ..
  70. ncbi Glutamate receptors in peripheral tissues: current knowledge, future research, and implications for toxicology
    S S Gill
    Health Canada, Ottawa, Ontario
    Toxicol Pathol 29:208-23. 2001
    We illustrate the specific cellular distribution of different subtypes of glutamate receptors (GluRs) in peripheral neural and non-neural tissues...
  71. pmc Altered hippocampal expression of glutamate receptors and transporters in GRM2 and GRM3 knockout mice
    Louisa Lyon
    Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, United Kingdom
    Synapse 62:842-50. 2008
    Group II metabotropic glutamate receptors (mGluR2 and mGluR3, also called mGlu2 and mGlu3, encoded by GRM2 and GRM3, respectively) are therapeutic targets for several psychiatric disorders...
  72. ncbi Glucocorticoid attenuates brain-derived neurotrophic factor-dependent upregulation of glutamate receptors via the suppression of microRNA-132 expression
    H Kawashima
    Administrative Section of Radiation Protection, National Institute of Neuroscience, National Center of Neurology and Psychiatry NCNP, Tokyo, Japan
    Neuroscience 165:1301-11. 2010
    ..Transfection of exogenous ds-miR-132 induced marked upregulation of glutamate receptors (NR2A, NR2B, and GluR1), suggesting that miR-132 has a positive effect on the increase in postsynaptic ..
  73. ncbi Histone methylation at gene promoters is associated with developmental regulation and region-specific expression of ionotropic and metabotropic glutamate receptors in human brain
    Florian Stadler
    Brudnick Neuropsychiatric Research Institute, Department of Psychiatry, University of Massachusetts Medical School, Worcester, Massachusetts 01604, USA
    J Neurochem 94:324-36. 2005
    ..regulation and maintenance of region-specific expression patterns of ionotropic and metabotropic glutamate receptors. The association of a specific epigenetic mark, H3-(methyl)-lysine 4, with the molecular architecture of ..
  74. ncbi Positive associations of polymorphisms in the metabotropic glutamate receptor type 3 gene (GRM3) with schizophrenia
    Yo Fujii
    Division of Disease Genes, Research Center for Genetic Information, Medical Institute of Bioregulation, Kyushu University, Japan
    Psychiatr Genet 13:71-6. 2003
    ..We have been conducting systematic studies on the association between glutamate receptors and schizophrenia...
  75. pmc Neuronal protein trafficking associated with Alzheimer disease: from APP and BACE1 to glutamate receptors
    Bor Luen Tang
    Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
    Cell Adh Migr 3:118-28. 2009
    ..Detail understanding of factors that influence these neuronal trafficking processes will open up novel therapeutic avenues for preventing or delaying the onset of symptomatic AD...
  76. ncbi Actin dynamics in dendritic spines: a form of regulated plasticity at excitatory synapses
    A Matus
    Friedrich Miescher Institute, Basel, Switzerland
    Hippocampus 10:555-60. 2000
    ....
  77. ncbi A novel postsynaptic density protein: the monocarboxylate transporter MCT2 is co-localized with delta-glutamate receptors in postsynaptic densities of parallel fiber-Purkinje cell synapses
    L Bergersen
    Department of Anatomy, Institute of Basic Medical Sciences, University of Oslo, Norway
    Exp Brain Res 136:523-34. 2001
    ..The expression of MCT2 in synaptic membranes may allow energy supply to be tuned to the excitatory drive...
  78. pmc Synaptic ionotropic glutamate receptors and plasticity are developmentally altered in the CA1 field of Fmr1 knockout mice
    Yair Pilpel
    Max Planck Institute for Medical Research, Department of Molecular Neurobiology, Heidelberg, Germany
    J Physiol 587:787-804. 2009
    ..We propose that ionotropic glutamate receptors, as well as potentiation, are altered at a critical time point for hippocampal network development, causing ..
  79. ncbi The postsynaptic architecture of excitatory synapses: a more quantitative view
    Morgan Sheng
    The Picower Institute for Learning and Memory, Howard Hughes Medical Institute, Departments of Brain and Cognitive Sciences, and Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Annu Rev Biochem 76:823-47. 2007
    ..The postsynaptic membrane contains a high concentration of glutamate receptors, associated signaling proteins, and cytoskeletal elements, all assembled by a variety of scaffold proteins ..
  80. pmc Glutamate receptor dynamics in dendritic microdomains
    Thomas M Newpher
    Department of Neurobiology, Duke University Medical Center, Durham, NC 27710, USA
    Neuron 58:472-97. 2008
    Among diverse factors regulating excitatory synaptic transmission, the abundance of postsynaptic glutamate receptors figures prominently in molecular memory and learning-related synaptic plasticity...
  81. ncbi Relative and absolute quantification of postsynaptic density proteome isolated from rat forebrain and cerebellum
    Dongmei Cheng
    Department of Human Genetics, Center for Neurodegenerative Disease, Emory University, Atlanta, Georgia 30322, USA
    Mol Cell Proteomics 5:1158-70. 2006
    ..protein kinase II and PSD-95 and reveal unexpected stoichiometric ratios between glutamate receptors, scaffold proteins, and signaling molecules in the PSD...
  82. ncbi Distal extension of climbing fiber territory and multiple innervation caused by aberrant wiring to adjacent spiny branchlets in cerebellar Purkinje cells lacking glutamate receptor delta 2
    Ryoichi Ichikawa
    Department of Anatomy, Hokkaido University School of Medicine, Sapporo 060 8638, Japan
    J Neurosci 22:8487-503. 2002
    ....
  83. ncbi Glutamate receptors and nociception: implications for the drug treatment of pain
    M E Fundytus
    Department of Oncology, McGill University, Montreal, Quebec, Canada
    CNS Drugs 15:29-58. 2001
    ..Glutamate and glutamate receptors are located in areas of the brain, spinal cord and periphery that are involved in pain sensation and ..
  84. pmc Hypoxic injury of isolated axons is independent of ionotropic glutamate receptors
    Suzanne M Underhill
    Hope Center for Neurological Disorders and Department of Neurology, 660 S Euclid Avenue, Campus Box 8111, Washington University School of Medicine, St Louis, MO 63110, USA
    Neurobiol Dis 25:284-90. 2007
    ..These results suggest that isolated, unmyelinated axons are vulnerable to hypoxic injury which is mediated by influx of sodium and calcium but is independent of glutamate receptor activation...
  85. pmc Molecular aspects of glutamate dysregulation: implications for schizophrenia and its treatment
    Christine Konradi
    Department of Psychiatry, Harvard Medical School, Boston, MA 02115, USA
    Pharmacol Ther 97:153-79. 2003
    ..Here we discuss how the molecular aspects of glutamate malfunction can explain some of the neuropathology observed in schizophrenia, and how the available treatment intervenes through the glutamate system...
  86. ncbi AMPA glutamate receptor-mediated calcium signaling is transiently enhanced during development of oligodendrocytes
    Takayuki Itoh
    The Children s Hospital of Philadelphia, Pennsylvania, USA
    J Neurochem 81:390-402. 2002
    ..lineage express Ca2+-permeable alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate-preferring glutamate receptors (AMPA-GluR) during development...
  87. ncbi The identity of plant glutamate receptors
    B Lacombe
    Science 292:1486-7. 2001
  88. ncbi Glutamate receptor function in learning and memory
    Gernot Riedel
    Department of Biomedical Sciences, University of Aberdeen, Foresterhill, UK
    Behav Brain Res 140:1-47. 2003
    ..Metabotropic glutamate receptors (mGluRs) may contribute very little to the actual acquisition of new information...
  89. ncbi Depressor and bradycardic responses to microinjections of endomorphin-2 into the NTS are mediated via ionotropic glutamate receptors
    Ken Kasamatsu
    Dept of Neurological Surgery, MSB H 586, UMDNJ New Jersey Medical School, 185 South Orange Ave, Newark, NJ 07103, USA
    Am J Physiol Regul Integr Comp Physiol 287:R715-28. 2004
    ..to microinjections of E-2 into the mNTS are mediated via micro(1)-opioid receptors as well as ionotropic glutamate receptors, 2) GABAergic neurons in the mNTS, which may inhibit the release of glutamate from nerve terminals, are ..
  90. ncbi Glutamate receptors at atomic resolution
    Mark L Mayer
    Building 35, Room 3B1002, Porter Neuroscience Research Center, 35 Lincoln Drive, Bethesda, Maryland 20892, USA
    Nature 440:456-62. 2006
    ....
  91. pmc Regulation of ionotropic glutamate receptors by their auxiliary subunits
    Susumu Tomita
    Program in Cellular Neuroscience, Neurodegeneration and Repair, Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut, USA
    Physiology (Bethesda) 25:41-9. 2010
    b>Glutamate receptors are major excitatory receptors in the brain. Recent findings have established auxiliary subunits of glutamate receptors as critical modulators of synaptic transmission, synaptic plasticity, and neurological disorder...
  92. pmc Dscam mediates remodeling of glutamate receptors in Aplysia during de novo and learning-related synapse formation
    Hsiu Ling Li
    Howard Hughes Medical Institute, Department of Neuroscience, College of Physicians and Surgeons of Columbia University, 1051 Riverside Drive, New York, NY 10032, USA
    Neuron 61:527-40. 2009
    ..Taken together, these findings suggest that learning-induced synapse formation recapitulates, at least in part, aspects of the mechanisms that govern de novo synaptogenesis...
  93. ncbi Chronic phencyclidine administration reduces the expression and editing of specific glutamate receptors in rat prefrontal cortex
    Alessandro Barbon
    Division of Biology and Genetics, Department of Biomedical Sciences and Biotechnologies, University of Brescia, Viale Europa 11, 25123 Brescia, Italy
    Exp Neurol 208:54-62. 2007
    ..Combining all the data, it can be inferred that the PCP treatment induced a specific and site-selective reduction of glutamatergic neurotransmission in the prefrontal cortex but not in the hippocampus...
  94. ncbi Glutamate receptors are expressed by bone cells and are involved in bone resorption
    C Chenu
    INSERM, Unit 403, Hopital E Herriot, Lyon, France
    Bone 22:295-9. 1998
    ..Glu) is a potent neurotransmitter in the central nervous system and exerts its action via a variety of glutamate receptors (GluRs)...
  95. ncbi Molecular mechanisms of glutamate-dependent neurodegeneration in ischemia and traumatic brain injury
    M Arundine
    Toronto Western Hospital Research Institute, Ontario, Canada
    Cell Mol Life Sci 61:657-68. 2004
    ....
  96. ncbi RNA editing in brain controls a determinant of ion flow in glutamate-gated channels
    B Sommer
    Laboratory for Molecular Neuroendocrinology, University of Heidelberg, Federal Republic of Germany
    Cell 67:11-9. 1991
    ..This process apparently edits subunit transcripts of the two glutamate receptor classes with different efficiency and selectivity...
  97. ncbi A single packet of transmitter does not saturate postsynaptic glutamate receptors
    Taro Ishikawa
    Department of Neurophysiology, University of Tokyo Graduate School of Medicine, 113 0033, Japan
    Neuron 34:613-21. 2002
    ..These results directly demonstrate that neither AMPA nor NMDA receptors are saturated by a single packet of transmitter, and indicate that vesicular transmitter content is an important determinant of synaptic efficacy...
  98. ncbi Interactions between ionotropic and metabotropic glutamate receptors regulate cAMP response element-binding protein phosphorylation in cultured striatal neurons
    L Mao
    Department of Pharmacology, School of Pharmacy, University of Missouri Kansas City, 2411 Holmes Street, Room M3 C225, 64108, USA
    Neuroscience 115:395-402. 2002
    ..regulates a variety of striatal neuronal activities via selective activation of ionotropic and metabotropic glutamate receptors (mGluRs)...
  99. ncbi Novel treatment of excitotoxicity: targeted disruption of intracellular signalling from glutamate receptors
    Michelle M Aarts
    Toronto Western Research Institute, McPav 11 416, 399 Bathurst Street, Toronto, Ont, Canada M5T 2S8
    Biochem Pharmacol 66:877-86. 2003
    ..Key molecules in these pathways are physically linked to the cytoplasmic face of glutamate receptors by scaffolding proteins that exhibit binding specificity for some receptors over others...
  100. ncbi Association study of polymorphisms in the group III metabotropic glutamate receptor genes, GRM4 and GRM7, with schizophrenia
    Hiroki Shibata
    Division of Human Molecular Genetics, Research Center for Genetic Information, Medical Institute of Bioregulation, Kyushu University, and Fukuoka Prefectural Dazaifu Hospital Psychiatric Center, Fukuoka, Japan
    Psychiatry Res 167:88-96. 2009
    ..We conclude that at least one susceptibility locus for schizophrenia is located within or nearby GRM7, whereas GRM4 is unlikely to be a major susceptibility gene for schizophrenia in the Japanese population...
  101. pmc Inspiratory bursts in the preBötzinger complex depend on a calcium-activated non-specific cation current linked to glutamate receptors in neonatal mice
    Ryland W Pace
    Department of Applied Science, McGlothlin Street Hall, Room 303, The College of William and Mary, Williamsburg, VA 23187 8795, USA
    J Physiol 582:113-25. 2007
    ..We found that NMDA receptors, group I metabotropic glutamate receptors (mGluRs), but not group II mGluRs, contributed to inspiratory drive potentials...

Research Grants75

  1. NIH Director's Pioneer Award
    ERICH JARVIS; Fiscal Year: 2009
    ..Repairing the pathway in vocal learners, when damaged, would have profound impact for correcting neurological disorders of speech. ..
  2. Physiology of Hypothalamic Neurosteroidal Progesterone
    Paul E Micevych; Fiscal Year: 2013
    ..This type of infertility exhibits excess estrogen production without ovulation that can lead to polycystic ovary syndrome, irregular vaginal bleeding, metabolic abnormalities as well as endometrial polyps, hyperplasia, and even cancer. ..
  3. Remodeling Neuronal Chromatin in Mouse Models for Depression
    Schahram Akbarian; Fiscal Year: 2013
    ..Then, indirectly, the chromatin changes brought about by Setdb1 result in certain adaptations in the communication between nerve cells, ultimately resulting in an antidepressant-like effect. ..
  4. Regulation of AKAP79 Postsynaptic Membrane Targeting
    MARK L DELL'ACQUA; Fiscal Year: 2012
    ..At the postsynaptic density (PSD) of neuronal excitatory synapses, AMPA (AMPAR) and NMDA (NMDAR) glutamate receptors are linked to signaling proteins and the actin cytoskeleton in dendritic spines through a network of ..
  5. Arcuate nucleus glutamatergic neurons modulate energy homeostasis
    Anthony N van den Pol; Fiscal Year: 2013
    ..abstract_text> ..
  6. Glutamate receptor recruitment to new synapses in vivo
    PHILIP ERIC WASHBOURNE; Fiscal Year: 2013
    ..SynCAM family members 1 and 2 can recruit both synaptic vesicles (SVs) to the presynaptic terminal and glutamate receptors to the postsynaptic specialization...
  7. Protection of Brain Injury from Cyanide Poisoning by Carnosic Acid
    Stuart A Lipton; Fiscal Year: 2013
    ..and ionic pump failure, contributing to excitotoxic neuronal cell death by overstimulation of NMDA-type glutamate receptors (NMDARs)...
  8. Interaction between RNA interference and RNA editing pathways
    Kazuko Nishikura; Fiscal Year: 2013
    ..Our research focuses also on apoptosis, which is highly relevant to many human diseases including cancer. ..
  9. Parvalbumin-Containing Neurons in Schizophrenia
    Tsung Ung W Woo; Fiscal Year: 2013
    ..Findings of the proposed studies are expected to shed light on the conceptualization of treatment and prevention strategies that aim at fundamentally correcting the underlying neural circuit deficits. ..
  10. Chromatin Modifications and Vulnerability to Glutamate Toxicity
    ALEXEI D KONDRATYEV; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Excessive activation of ionotropic glutamate receptors increases oxidative stress, which contributes to the neurodegeneration observed following neurological insults such as ischemia and seizures, as ..
  11. GLUTAMATE TRANSPORTERS IN THE CNS
    MICHAEL BYRNE ROBINSON; Fiscal Year: 2011
    ..and to prevent excessive activation of receptors that can kill neurons (or other cells that express glutamate receptors)...
  12. Microvascular Dysfunction in Hyperhomocysteinemia
    Shawn E Bearden; Fiscal Year: 2012
    ..We develop the novel hypothesis that homocysteine activates metabotropic glutamate receptors on endothelial cells, mediating a G-protein cascade through phosphokinase C (PKC) and serine ..
  13. Control of Cardiogenesis by microRNA Editing
    Kazuko Nishikura; Fiscal Year: 2010
    ....
  14. Autoimmunity Against Novel Antigens in Neuropsychiatric Dysfunction
    Josep O Dalmau; Fiscal Year: 2013
    ....
  15. Plasticity of nTS output neurons in acute and chronic hypoxia
    DAVID DOUGLAS KLINE; Fiscal Year: 2013
    ..fibers to the caudal nucleus tractus solitarius (nTS) where glutamate is released and binds to ionotropic glutamate receptors. The afferent signal is then integrated within the nTS to produce the final output within the nTS- ..
  16. Synaptic autoimmunity in disorders of memory, behavior, cognition and psychosis
    Josep Dalmau; Fiscal Year: 2010
    ....
  17. Kynurenic Acid Synthesis in Mouse Brain
    Jianyong Li; Fiscal Year: 2010
    ..The research described in this proposal investigates physiology and biochemistry of enzymes responsible for the production of brain KYNA using mice as model species. ..
  18. Neuroprotective strategies in seizure-induced damage
    JANA VELISKOVA; Fiscal Year: 2011
    ..As this finding suggests participation of slow, G-protein linked neurotransmitter systems, metabotropic glutamate receptors (mGluR) and neuropeptide Y (NPY) were investigated...
  19. SK channels: Roles and mechanisms for dendritic excitability and plasticity
    James G Maylie; Fiscal Year: 2012
    ....
  20. Biobehavioral Role of Brain Kynurenine Metabolism in Mental Illness
    JASON C O'CONNOR; Fiscal Year: 2013
    ..Successfully unraveling these molecular networks will enable the development of novel therapeutic strategies to treat inflammation-induced depression. ..
  21. Role of Gprotein and SNAP-25 in NMDA vs mGluR presynaptic long-term plasticity
    KATISHA ROSE GOPAUL; Fiscal Year: 2013
    ..At the cellular level, induction of LTP/LTD involve activation of multiple subtypes of glutamate receptors that mediate or regulate local neuronal influx/release of calcium and other second messengers...
  22. 2012 Fragile X and Autism-Related Disorders: From Basic Neuroscience to Improved
    ELIZABETH MARA BERRY-KRAVIS; Fiscal Year: 2012
    ..synapse, via a specific set of Gq-linked neurotransmitter receptors, including group I mGluRs (metabotropic glutamate receptors)...
  23. Cell Communication of the Vertebrate Retina
    ROBERT FRANCIS MILLER; Fiscal Year: 2012
    ..First the NMDA receptors are unique among glutamate receptors because of their relationship to excitotoxicity, created by their permeability to calcium and induced by ..
  24. The Role of Intracellular Metabotropic Glutamate Receptor 5 at the Synapse
    CAROLYN ANN PURGERT; Fiscal Year: 2012
    ..For Fragile X Syndrome and possibly autism, understanding the role of intracellular mGluR5 will be crucial in developing suitable mGluR5 antagonists for therapeutic treatments. ..
  25. Sex Hormones and Visceral Hypersensitivity
    Elie D Al-Chaer; Fiscal Year: 2012
    ..iii) via direct action on estrogen receptors located on PSDC neurons or iv) via regulation of glutamate receptors located on these neurons...
  26. SK2 Channels as Novel Neuroprotective Targets Against Cerebral Ischemia
    Paco S Herson; Fiscal Year: 2012
    ..from increased glutamate neurotransmission, and the consequent excessive Ca2+ influx through NMDA-type glutamate receptors (NMDAr)...
  27. CaMKII in global cerebral ischemia
    Paco S Herson; Fiscal Year: 2013
    ..in large part due to glutamate excitotoxicity triggered by a pathological flood calcium through NMDA-type glutamate receptors (NMDAr), ultimately resulting in neuronal cell death...
  28. Mechanisms of regulation of ethanol intake by lateral habenula
    Jiang Hong Ye; Fiscal Year: 2013
    ..CIESA on the activity of neurons in the LHb and RMTg by means of Fos immunoreactivity, on protein levels of glutamate receptors using Western blotting, and extracellular levels of glutamate in the LHb and RMTg using microdialysis ..
  29. Astrocyte Function and Temporal Lobe Epilepsy
    JAY ROBERT VARGAS; Fiscal Year: 2010
    ..It is anticipated that this work will reveal new potential therapeutic targets for the treatment of epilepsy. ..
  30. Regulation of AKAP79 Postsynaptic Targeting and Signaling
    MARK L DELL'ACQUA; Fiscal Year: 2013
    ..LTP and LTD are induced by Ca2+ influx through NMDA glutamate receptors (NMDAR) and expressed by long-lasting increases or decreases, respectively, in AMPA glutamate receptor (..
  31. Control of AMPA receptor function by phosphorylation
    Stephen F Traynelis; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The AMPA-type glutamate receptors are ligand-gated cation channels that mediate fast excitatory neurotransmission in the brain, and thus are critically involved in all aspects of brain function ..
  32. NEUROCHEMICAL PHARMACOLOGY OF PHENCYCLIDINE
    Kenneth Johnson; Fiscal Year: 2009
    ..and 3) to determine the role of altering neuronal glutamate release by activation of metabotropic glutamate receptors in PCP-mediated neurotoxicity...
  33. Mechanisms of Stress-Enhanced Aversive Conditioning
    Jelena Radulovic; Fiscal Year: 2013
    ..The glutamatergic and oxytocinergic systems, acting via metabotropic glutamate receptors 5 (mGluR5) and oxytocin receptors (Oxtr), respectively, are potently activated during social interactions ..
  34. mGluR5 antagonists for methamphetamine addiction
    M Foster Olive; Fiscal Year: 2012
    ....
  35. Mechanism of action of novel GluN2C NMDA receptor potentiators
    Alpa Khatri; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The ionotropic glutamate receptors family includes the N-methyl D-aspartate (NMDA), alpha-amino-3- hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA), kainate, and delta receptors, mediate the ..
  36. Neuronal-Astrocytic Communication In Vivo
    KEN DOUGLAS MCCARTHY; Fiscal Year: 2013
    ..increases in astrocytic Ca2+ in situ lead to the release of glutamate that can activate both metabotropic glutamate receptors (mGluRs) and ionotropic glutamate receptors (iGluRs) on pre- and postsynaptic neuronal membranes...
  37. NORADRENERGIC SYSTEM IN DEPRESSION
    GREGORY ALLEN ORDWAY; Fiscal Year: 2012
    ..One source of this abnormality may be glia, since glia express glutamate receptors and transporters and contribute substantially to glutamate uptake...
  38. Role of MEF2 and neural activity in cortical synaptic weakening and elimination
    Kimberly M Huber; Fiscal Year: 2013
    ..transcription which primes CA1 neurons for long-term synaptic depression upon activation of metabotropic glutamate receptors (mGluR-LTD)...
  39. Assessing the effects of Synj1 haploinsufficiency in Alzheimer's disease models
    Gilbert Di Paolo; Fiscal Year: 2010
    ..The goal of this proposal is to assess whether genetically decreasing the catabolism of PtdIns(4,5)P2 in the brain of AD mouse models can ameliorate learning and memory deficits in various behavioral tasks. ..
  40. Kainate receptor signaling in striatal synaptic function and plasticity
    John Marshall; Fiscal Year: 2012
    ..While currently 30% of OCD cases are intractable, understanding these biochemical and synaptic abnormalities will lead to treatments that are more effective, specific, and give rise to fewer complications. ..
  41. PDZ DOMAINS AND AMPA RECEPTOR FUNCTION
    Richard L Huganir; Fiscal Year: 2013
    ..This research may therefore reveal novel targets for the development of therapeutic treatments for several brain disorders including pain, drug addiction, schizophrenia, autism, and Alzheimer's and Parkinson's disease. ..
  42. THE ROLE OF METABOTROPIC GLUTAMATE RECEPTOR 5 (MGLUR5) IN BLADDER PAIN
    HING HUNG HENRY LAI; Fiscal Year: 2013
    ..The approach also provides an optimal training platform for Dr. Lai to learn new expertise in molecular/behavioral pain research and neuroscience to become an independent researcher. ..
  43. NG2 cell dynamics in the normal and injured adult central nervous system
    Ethan Hughes; Fiscal Year: 2012
    ..NG2 cells express ionotropic glutamate receptors, and are unique among glial cells in that they form direct synapses with neurons, providing a means by ..
  44. Structure and Finction of AMPA subtype ionotropic glutamate receptors
    ALEXANDER SOBOLEVSKY; Fiscal Year: 2013
    PROJECT SUMMARY AMPA ([unreadable]-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) subtype ionotropic glutamate receptors mediate the majority of excitatory neurotransmission in the central nervous system...
  45. Glutamate, aging and enriched environment after dopamine loss
    CHARLES KENNETH MESHUL; Fiscal Year: 2013
    ..We will further determine if blockade of SN glutamate receptors or increasing striatal glutamate following MPTP will both mimic the affect of exposure to an EE...
  46. PRESYNAPTIC LONG-TERM SYNAPTIC DEPRESSION
    Patric K Stanton; Fiscal Year: 2012
    ..on activation of N-methyl-D-aspartate receptors (NMDAR), or on co-activation of group I and II metabotropic glutamate receptors. Using two-photon laser scanning microscopy of FM1-43 release from hippocampal synaptic terminals, we have ..
  47. Human Umami Taste: Genetics of Psychophysical Traits
    Paul A S Breslin; Fiscal Year: 2012
    ..Three classes of glutamate receptors found within taste receptor cells have been associated with cell signaling in response to amino acids and ..
  48. REGULATION OF SYNAPSE ELIMINATION BY FMRP
    JULIA RIVES WILKERSON; Fiscal Year: 2011
    ..regulate synaptic function;FMRP regulates Arc translation in response to activation of group I metabotropic glutamate receptors (Waung et al. 2008)...
  49. HORMONE-NEUROTRANSMITTER INTERACTIONS IN THE BRAIN
    Elaine M Hull; Fiscal Year: 2011
    ..GABA or glutamate release and whether subtypes of DA receptors are located on neurons that contain NMDA glutamate receptors or GABA...
  50. Mechanisms of Altered Gastrointestinal Dysfunction
    QiQi Zhou; Fiscal Year: 2013
    ..should identify critical contributions of aberrantly expressed miRNAs that target downstream opioid and glutamate receptors in intestinal tissues of IBS patients with visceral hypersensitivity This will bridge an important gap in ..
  51. The Functional Significance of Conformational States in Glutamatergic Signaling
    CATHERINE LOURDES SALUSSOLIA; Fiscal Year: 2013
    ..Thus, understanding gating mechanisms are critical to developing novel therapeutic agents. Glutamate receptors (GluRs) are tetramers being composed of identical or similar subunits...
  52. RAPID NEURAL DIFFERENTIATION OF HUMAN STEM CELLS: A NOVEL DRUG DISCOVERY PLATFORM
    MARIA INES MORANO; Fiscal Year: 2010
    ..of such a platform for cell-based assays will be demonstrated by examining the response of metabotropic glutamate receptors in differentiated human neurons...
  53. Steroid Catecholamine Interactions and Behavior
    Gregory F Ball; Fiscal Year: 2013
    ..We will assess how behavioral situations that modulate motivation might also modulate aromatase that in turn will affect how much estradiol is available in specific brain areas related to behavioral activation. ..
  54. Sp4 Pathway in the Modulation of Sensorimotor Gating and Memory
    XIANJIN ZHOU; Fiscal Year: 2013
    ..CA1, impaired spatial learning, and markedly decreased the expression of NMDAR1, the core subunit for NMDA glutamate receptors. Impaired NMDA function plays a central role in the pathophysiology of schizophrenia...
  55. NEUROBIOLOGY OF NICOTINE REWARD AND WITHDRAWAL
    Athina Markou; Fiscal Year: 2011
    ..that: a) decreasing glutamate transmission at postsynaptic metabotropic (mGluR) and ionotropic (iGluR) glutamate receptors decreases the reinforcing effects of nicotine;and b) during the development of nicotine dependence there ..
  56. Ph 2 Study of Dextromethorphan in the Treatment of Rett Syndrome
    SAKKUBAI R NAIDU; Fiscal Year: 2013
    ..girls less than 8 years of age with RTT showed a significant increase in NMDA-type (N-methyl-D-aspartate) glutamate receptors despite a 50% reduction in the number of synapses...
  57. Pharmacokinetic and pharmacodynamic optimization of soluble Abeta oligomer recept
    Susan M Catalano; Fiscal Year: 2012
    ..Such an optimized IND Abeta oligomer receptor antagonist candidate would be among the first small molecule drugs to reverse AD and MCI symptoms and block disease progression. ..
  58. A role for ephrins-A2, -A3, &-A5 in excitatory synaptic development and function
    Rachel Wurzman; Fiscal Year: 2013
    ..These studies will thus evaluate genetic factors that could contribute at multiple levels to the etiology of developmental neuropsychiatric disorders. ..
  59. The role of Kainate receptors in oligodendrocyte toxicity and EAE
    Geoffrey T Swanson; Fiscal Year: 2010
    ..we will test the hypothesis that pharmacological targeting of kainate receptors, a family of ionotropic glutamate receptors, represents a viable therapeutic strategy in an animal model of multiple sclerosis (MS)...
  60. The ability of the transcription factor CREB in the Nac to regulate mood
    Ronald S Duman; Fiscal Year: 2011
    ..g., MCH in Project 3), and by characterizing their role in mediating CREB's complex behavioral phenotype related to depression and its treatment. ..
  61. Modulation of GABAB receptor signaling
    Stephen J Moss; Fiscal Year: 2010
    ..Given the established role of glutamate receptors in ischemia-induced excitotoxicity we have begun to explore the link between their activation and the ..
  62. DAPK1 regulation of NMDA receptors in ischemic neuronal death
    NICOLAS GUILLERMO BAZAN; Fiscal Year: 2012
    N-methyl-D-aspartate (NMDA) receptors constitute the major subtype of glutamate receptors and normally participate in rapid excitatory synaptic transmission throughout the CNS...
  63. Prodrugs of NAAG Peptidase Inhibitors for the Treatment of Schizophrenia
    Jia Zhou; Fiscal Year: 2009
    ....
  64. Neuroprotective Drugs for Spinal Cord Injury
    JEAN WRATHALL; Fiscal Year: 2001
    ..It is presumed that a single volume will be used and the concentration of drug varied, but this is not spelled out. ..
  65. Balanced, polyvalent antiglutamatergic action as a novel approach to efficacious
    Anatoly Martynyuk; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Excessively activated ionotropic glutamate receptors of both the N-methyl-D-aspartate (NMDA) and (RS)-amino-3-hydroxy-5-methyl-4-isoxazolepropioinic acid (AMPA)/kainate subtypes initiate numerous ..
  66. METABOTROPIC GLUTAMATE RECEPTORS IN NEURODEGENERATION
    Anne Young; Fiscal Year: 2009
    ..Specifically, one class of glutamate receptors, the metabotropic glutamate receptors (mGluRs), may be specifically abnormal in many of the ..
  67. Role of AMPA receptors in the nucleus accumbens shell in morphine depedence
    Elena Chartoff; Fiscal Year: 2009
    ..provided by applicant): The purpose of this R03 proposal is to investigate how synaptic plasticity of AMPA glutamate receptors in the nucleus accumbens shell (NASh) mediates morphine dependence...
  68. Canonical Transient Receptor Potential Channels and Excitotoxicity
    Fang Zheng; Fiscal Year: 2010
    ..Overactivation of glutamate receptors leads to calcium overloading, triggering neuronal cell death...
  69. Allosteric Modulators of Glutamate Receptors
    Robert E Oswald; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Ionotropic glutamate receptors control a wide variety of normal neuronal processes including learning and memory...
  70. Potential use of a decoy peptide for hypoxia/ischemia treatment
    Michel Baudry; Fiscal Year: 2010
    ..not completely understood, it has repeatedly been proposed that excitotoxicity due to over-excitation of glutamate receptors plays a critical role...
  71. Identification of ligands that bind to the orphan delta2 receptor
    Stephen Traynelis; Fiscal Year: 2009
    ..the possibility that incorporation of the delta2 subunit into heteromeric receptor assemblies may endow glutamate receptors with a regulatory site for D-serine...
  72. INTEGRIN REGULATION AND FUNCTIONS IN ADULT BRAIN
    Christine Gall; Fiscal Year: 2007
    ..to the further discovery that GRGDSP treatment increases synaptic currents mediated by AMPA- and NMDA-class glutamate receptors and phosphorylation of the glutamate receptor themselves...
  73. ETHANOL INHIBITION OF NMDA RECETOR MEDIATED RESPONSES
    David Lovinger; Fiscal Year: 2000
    ..Ethanol potently inhibits the function of N- methyl-D-aspartate type glutamate receptors (NMDARs)...
  74. ETHANOL INHIBITION OF NMDA RECEPTOR MEDIATED RESPONSES
    Danny Winder; Fiscal Year: 2004
    ..Ethanol potently inhibits the function of N- methyl-D-aspartate type glutamate receptors (NMDARs)...
  75. Extracellular Modulation of Metabotropic GluRs
    Julie Saugstad; Fiscal Year: 2005
    ..amino acid neurotransmitter in the central nervous system (CNS) and activates two distinct families of glutamate receptors (GluRs)...