gaba receptors

Summary

Summary: Cell-surface proteins that bind GAMMA-AMINOBUTYRIC ACID with high affinity and trigger changes that influence the behavior of cells. GABA-A receptors control chloride channels formed by the receptor complex itself. They are blocked by bicuculline and usually have modulatory sites sensitive to benzodiazepines and barbiturates. GABA-B receptors act through G-proteins on several effector systems, are insensitive to bicuculline, and have a high affinity for L-baclofen.

Top Publications

  1. ncbi Insect GABA receptors: splicing, editing, and targeting by antiparasitics and insecticides
    Steven David Buckingham
    Medical Research Council Functional Genetics Unit, Department of Human Anatomy and Genetics, University of Oxford, UK
    Mol Pharmacol 68:942-51. 2005
  2. ncbi Evidence for a diverse Cys-loop ligand-gated ion channel superfamily in early bilateria
    Joseph A Dent
    Department of Biology, McGill University, 1205 Dr Penfield Avenue, Montreal, Quebec H3A 1B1, Canada
    J Mol Evol 62:523-35. 2006
  3. ncbi Activation of spinal GABA receptors attenuates chronic central neuropathic pain after spinal cord injury
    Young Seob Gwak
    Department of Physiology, Brain Research Institute, and Brain Korea 21 Project for Medical Sciences, Yonsei University College of Medicine, Seoul, South Korea
    J Neurotrauma 23:1111-24. 2006
  4. ncbi Spinal GABA receptors mediate the suppressive effect of electroacupuncture on cold allodynia in rats
    Jung Hyun Park
    Department of East West Medicine, Graduate School, Kyung Hee University, Seoul 130 701, South Korea
    Brain Res 1322:24-9. 2010
  5. pmc Evidence that GABA rho subunits contribute to functional ionotropic GABA receptors in mouse cerebellar Purkinje cells
    Victoria L Harvey
    School of Pharmacy, University of Reading, Whiteknights, PO Box 228, Reading RG6 6AJ, UK
    J Physiol 577:127-39. 2006
  6. ncbi VDAC activation by the 18 kDa translocator protein (TSPO), implications for apoptosis
    Leo Veenman
    Department of Molecular Pharmacology, Rappaport Family Institute for Research in the Medical Sciences, Technion Israel Institute of Technology, Ephron Street, Bat Galim, Haifa, Israel
    J Bioenerg Biomembr 40:199-205. 2008
  7. ncbi Potential roles of GABA receptors in morphine self-administration in rats
    Seong Shoon Yoon
    College of Pharmacy, Yeungnam University, Gyeongsan, South Korea
    Neurosci Lett 428:33-7. 2007
  8. ncbi Synaptic strength between motoneurons and terminals of the dorsolateral funiculus is regulated by GABA receptors in the turtle spinal cord
    Rodolfo Delgado-Lezama
    Departamento de Fisiologia, Biofisica y Neurociencias, del Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, 07000 Mexico D F, Mexico
    J Neurophysiol 91:40-7. 2004
  9. ncbi GABA receptors containing Rdl subunits mediate fast inhibitory synaptic transmission in Drosophila neurons
    Daewoo Lee
    Departments of Anatomy and Neurobiology, Developmental and Cell Biology, University of California, Irvine, California 92697 1280
    J Neurosci 23:4625-34. 2003
  10. ncbi Wild-type and insecticide-resistant homo-oligomeric GABA receptors of Drosophila melanogaster stably expressed in a Drosophila cell line
    S D Buckingham
    Babraham Institute Laboratory of Molecular Signalling, Department of Zoology, University of Cambridge, UK
    Neuropharmacology 35:1393-401. 1996

Detail Information

Publications226 found, 100 shown here

  1. ncbi Insect GABA receptors: splicing, editing, and targeting by antiparasitics and insecticides
    Steven David Buckingham
    Medical Research Council Functional Genetics Unit, Department of Human Anatomy and Genetics, University of Oxford, UK
    Mol Pharmacol 68:942-51. 2005
    Ionotropic GABA receptors are abundant in both vertebrate and invertebrate nervous systems, where they mediate rapid, mostly inhibitory synaptic transmission...
  2. ncbi Evidence for a diverse Cys-loop ligand-gated ion channel superfamily in early bilateria
    Joseph A Dent
    Department of Biology, McGill University, 1205 Dr Penfield Avenue, Montreal, Quebec H3A 1B1, Canada
    J Mol Evol 62:523-35. 2006
    ..Many of these disappeared from the chordates. Subsequently, selected subunit genes expanded to form large subfamilies...
  3. ncbi Activation of spinal GABA receptors attenuates chronic central neuropathic pain after spinal cord injury
    Young Seob Gwak
    Department of Physiology, Brain Research Institute, and Brain Korea 21 Project for Medical Sciences, Yonsei University College of Medicine, Seoul, South Korea
    J Neurotrauma 23:1111-24. 2006
    ....
  4. ncbi Spinal GABA receptors mediate the suppressive effect of electroacupuncture on cold allodynia in rats
    Jung Hyun Park
    Department of East West Medicine, Graduate School, Kyung Hee University, Seoul 130 701, South Korea
    Brain Res 1322:24-9. 2010
    ..These results suggest that spinal GABA(A) and GABA(B) receptors mediate the suppressive effect of low frequency EA on cold allodynia in the tail neuropathic rats...
  5. pmc Evidence that GABA rho subunits contribute to functional ionotropic GABA receptors in mouse cerebellar Purkinje cells
    Victoria L Harvey
    School of Pharmacy, University of Reading, Whiteknights, PO Box 228, Reading RG6 6AJ, UK
    J Physiol 577:127-39. 2006
    ..cells (PCs) using agents reported to have increased affinity for rho subunit-containing GABA(C) over other GABA receptors. Exogenous application of the GABA(C)-preferring agonist cis-4-aminocrotonic acid (CACA) evoked whole-cell ..
  6. ncbi VDAC activation by the 18 kDa translocator protein (TSPO), implications for apoptosis
    Leo Veenman
    Department of Molecular Pharmacology, Rappaport Family Institute for Research in the Medical Sciences, Technion Israel Institute of Technology, Ephron Street, Bat Galim, Haifa, Israel
    J Bioenerg Biomembr 40:199-205. 2008
    ..These data provide an understanding regarding the mechanisms whereby VDAC and TSPO may serve as targets to modulate apoptotic rates. This has implications for drug design to treat diseases such as neurodegeneration and cancer...
  7. ncbi Potential roles of GABA receptors in morphine self-administration in rats
    Seong Shoon Yoon
    College of Pharmacy, Yeungnam University, Gyeongsan, South Korea
    Neurosci Lett 428:33-7. 2007
    ..These data suggest that activation of both GABA(A) and GABA(B) receptors may be effective in suppressing the reinforcing effects of morphine...
  8. ncbi Synaptic strength between motoneurons and terminals of the dorsolateral funiculus is regulated by GABA receptors in the turtle spinal cord
    Rodolfo Delgado-Lezama
    Departamento de Fisiologia, Biofisica y Neurociencias, del Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, 07000 Mexico D F, Mexico
    J Neurophysiol 91:40-7. 2004
    ..This suggests that baclofen decreased the synaptic strength by inhibition of neurotransmitter release from the DLF terminals via activation of presynaptic GABAB receptors...
  9. ncbi GABA receptors containing Rdl subunits mediate fast inhibitory synaptic transmission in Drosophila neurons
    Daewoo Lee
    Departments of Anatomy and Neurobiology, Developmental and Cell Biology, University of California, Irvine, California 92697 1280
    J Neurosci 23:4625-34. 2003
    ..However, the functional properties of synaptic GABA receptors in Drosophila have not been described...
  10. ncbi Wild-type and insecticide-resistant homo-oligomeric GABA receptors of Drosophila melanogaster stably expressed in a Drosophila cell line
    S D Buckingham
    Babraham Institute Laboratory of Molecular Signalling, Department of Zoology, University of Cambridge, UK
    Neuropharmacology 35:1393-401. 1996
    ..Stable cell lines are now available expressing susceptible and resistant forms of an ionotropic receptor by GABAergic insecticides...
  11. ncbi Molecular modeling of the GABA(C) receptor ligand-binding domain
    Neil J Harrison
    Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QW, UK
    J Mol Model 12:317-24. 2006
    ..Figure: see text]...
  12. pmc Agonist pharmacology of two Drosophila GABA receptor splice variants
    A M Hosie
    Department of Zoology, University of Cambridge
    Br J Pharmacol 119:1577-85. 1996
    ..the two homo-oligomers and their agonists pharmacology compared with that of insect and vertebrate iontropic GABA receptors. 2...
  13. ncbi Contribution of GABA receptors to extinction of memory traces in normal conditions and in a depression-like state
    N I Dubrovina
    State Science Research Institute of Physiology, Siberian Branch, Russian Academy of Medical Sciences, 4 Timakov Street, 630117, Novosibirsk, Russia
    Neurosci Behav Physiol 38:775-9. 2008
    A relationship between the effects of activation and blockade of GABA receptors on extinction of a conditioned passive avoidance reaction on the one hand and the type of receptor and initial psychoemotional state on the other was found in ..
  14. ncbi Changes of GABA receptors and dopamine turnover in the postmortem brains of parkinsonians with levodopa-induced motor complications
    Frederic Calon
    Molecular Endocrinology and Oncology Research Center, Laval University Medical Center CHUL, Laval University, 2705 Laurier Boulevard, Quebec, PQ G1V 4G2, Canada
    Mov Disord 18:241-53. 2003
    ..The present results also suggest that an up-regulation of GABA(A) receptors in the internal globus pallidus is linked to the pathogenesis of levodopa-induced dyskinesias...
  15. pmc Alcohol-sensitive GABA receptors and alcohol antagonists
    Steven M Paul
    Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, USA
    Proc Natl Acad Sci U S A 103:8307-8. 2006
  16. ncbi BDNF regulates the maturation of inhibition and the critical period of plasticity in mouse visual cortex
    Z J Huang
    Center for Learning and Memory, Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
    Cell 98:739-55. 1999
    ..We propose that BDNF promotes the maturation of cortical inhibition during early postnatal life, thereby regulating the critical period for visual cortical plasticity...
  17. pmc A unique amino acid of the Drosophila GABA receptor with influence on drug sensitivity by two mechanisms
    H G Zhang
    Department of Physiology, Medical School, College of Agricultural and Life Sciences, University of Wisconsin, Madison 53706
    J Physiol 479:65-75. 1994
    ..Patch clamp analysis of GABA receptors in cultured neurons from wild type and mutant Drosophila was undertaken to investigate the biophysical basis ..
  18. pmc GABA receptors modulate trigeminovascular nociceptive neurotransmission in the trigeminocervical complex
    R J Storer
    Headache Group, Institute of Neurology, The National Hospital for Neurology and Neurosurgery, Queen Square, London
    Br J Pharmacol 134:896-904. 2001
    ..GABA(A) receptors may therefore provide a target for the development of new therapeutic agents for primary headache disorders...
  19. ncbi Astrocytic GABA receptors
    D D Fraser
    Neuroscience Research Group, University of Calgary, Alberta, Canada
    Glia 11:83-93. 1994
    b>GABA receptors are distributed widely throughout the central nervous system on a variety of cell types. It has become increasingly clear that astrocytes, both in cell culture and tissue slices, express abundant GABAA receptors...
  20. ncbi Enhanced activity of GABA receptors inhibits glutamate release induced by focal cerebral ischemia in rat striatum
    Changhan Ouyang
    Department of Pharmacology, Tongji Medical College of Huazhong University of Science and Technology, Wuhan 430030, PR China
    Neurosci Lett 420:174-8. 2007
    ..receptor, triggered by cerebral ischemia, can be down-regulated by exogenous GABA or by increased activity of GABA receptors, especially the presynaptic GABA(B) receptors, which might be one of the important mechanisms to protect ..
  21. pmc Actions of the insecticide fipronil, on dieldrin-sensitive and- resistant GABA receptors of Drosophila melanogaster
    A M Hosie
    Babraham Institute Laboratory of Molecular Signalling, Department of Zoology, Cambridge
    Br J Pharmacol 115:909-12. 1995
    ..As the mutation A302-->S reduces the potency of both fipronil and picrotoxinin, homooligomeric RDL receptors should facilitate detailed studies of the molecular basis of convulsant/insecticide antagonist actions on GABA receptors.
  22. ncbi The evolution of GABAA receptor-like genes
    Shui Ying Tsang
    Department of Biochemistry and Applied Genomics Laboratory, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong
    Mol Biol Evol 24:599-610. 2007
    ....
  23. pmc Joint manipulation reduces hyperalgesia by activation of monoamine receptors but not opioid or GABA receptors in the spinal cord
    D A Skyba
    Neuroscience Graduate Program, University of Iowa, Iowa City, IA, USA
    Pain 106:159-68. 2003
    ..Thus, the antihyperalgesia produced by joint manipulation appears to involve descending inhibitory mechanisms that utilize serotonin and noradrenaline...
  24. ncbi Evidence for a GABAergic system in rodent and human testis: local GABA production and GABA receptors
    Christof Geigerseder
    Anatomisches Institut der Universität München, Munchen, Deutschland
    Neuroendocrinology 77:314-23. 2003
    ..GABA and GABA receptors are, however, also present in several non-neural tissues, including the endocrine organs pituitary, pancreas ..
  25. ncbi Molecular cloning, genomic structure, and genetic mapping of two Rdl-orthologous genes of GABA receptors in the diamondback moth, Plutella xylostella
    Guorui Yuan
    College of Plant Protection, Nanjing Agricultural University, Key Laboratory of Monitoring and Management of Crop Diseases and Pest Insects Ministry of Agriculture of China, Nanjing, China
    Arch Insect Biochem Physiol 74:81-90. 2010
    ..Two Rdl-orthologous genes of GABA receptors (PxGABARalpha1 and PxGABARalpha2) were cloned and sequenced from a susceptible strain (Roth) of Plutella ..
  26. ncbi Modeling of evoked field potentials in hippocampal CA1 area describes their dependence on NMDA and GABA receptors
    A R Sargsyan
    Department of Physiology, Medical School, University of Patras, 26500 Patras, Greece
    J Neurosci Methods 104:143-53. 2001
    ..The modeled interaction of NMDA and GABA components could explain the enhancement of the field potential late phase, which was observed experimentally during paired-pulse stimulation...
  27. ncbi The 'ABC' of GABA receptors: a brief review
    M Chebib
    Adrien Albert Laboratory of Medicinal Chemistry, Department of Pharmacology, University of Sydney, New South Wales, Australia
    Clin Exp Pharmacol Physiol 26:937-40. 1999
    ..Conformationally restricted analogues of GABA have been used to help identify three major GABA receptors, termed GABAA, GABAB and GABAC receptors. 2...
  28. ncbi Modulation of the components of the rat dark-adapted electroretinogram by the three subtypes of GABA receptors
    Anna Möller
    Department of Physiology, University of Iceland IS 101 Reykjavik, Iceland
    Vis Neurosci 20:535-42. 2003
    ..purpose of this study was to examine whether selective blockage or stimulation of the different subtypes of GABA receptors might help further elucidate the cellular origin of the components of the dark-adapted ERG...
  29. ncbi Presynaptic ionotropic GABA receptors
    Andreas Draguhn
    Institut fur Physiologie und Pathophysiologie, Universitat Heidelberg, Im Neuenheimer Feld 326, 69120 Heidelberg, Germany
    Results Probl Cell Differ 44:69-85. 2008
    ..in the spinal cord, recent work has revealed an astonishing abundance and diversity of presynaptic ionotropic GABA receptors. While modern techniques allow for detailed studies at the cellular and molecular level in almost all regions ..
  30. pmc The cholinergic antagonist alpha-bungarotoxin also binds and blocks a subset of GABA receptors
    Corey M McCann
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Proc Natl Acad Sci U S A 103:5149-54. 2006
    ..These results introduce a previously unrecognized tool for analysis of GABA(A)Rs but may complicate interpretation of some studies on neuronal nAChRs...
  31. ncbi Molecular biology of insect neuronal GABA receptors
    A M Hosie
    Babraham Institute, Dept of Zoology, Cambridge, UK
    Trends Neurosci 20:578-83. 1997
    ..Although insect and vertebrate GABA receptors share a number of structural and functional similarities, their pharmacology differs in several aspects...
  32. ncbi Taurine prevents the neurotoxicity of beta-amyloid and glutamate receptor agonists: activation of GABA receptors and possible implications for Alzheimer's disease and other neurological disorders
    Paulo Roberto Louzada
    Departamento de Bioquimica Medica, Instituto de Ciencias Biomedicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ 21941 590, Brasil
    FASEB J 18:511-8. 2004
    ..These results suggest that activation of GABA receptors decreases neuronal vulnerability to excitotoxic damage and that pharmacological manipulation of the excitatory ..
  33. pmc A novel insertion pathway of mitochondrial outer membrane proteins with multiple transmembrane segments
    Hidenori Otera
    Department of Molecular Biology, Graduate School of Medical Science, Kyushu University, Fukuoka 812 8582, Japan
    J Cell Biol 179:1355-63. 2007
    ..These findings reveal a previously unidentified pathway of the membrane integration of MOM proteins with multiple TMSs...
  34. pmc One GABA and two acetylcholine receptors function at the C. elegans neuromuscular junction
    J E Richmond
    Department of Biology, University of Utah, 257 South 1400 East, Salt Lake City, Utah 84112 0840, USA
    Nat Neurosci 2:791-7. 1999
    ..By recording spontaneous endogenous currents and selectively eliminating each of these receptors, we demonstrated that all three receptor types function at neuromuscular synapses...
  35. pmc Early evolution of ionotropic GABA receptors and selective regimes acting on the mammalian-specific theta and epsilon subunits
    Christopher J Martyniuk
    Department of Biology and Centre for Advanced Research in Environmental Genomics, University of Ottawa, Ottawa, Ontario, Canada
    PLoS ONE 2:e894. 2007
    ..Here, we investigate the phylogenetic relationships of GABA receptor subunits across the chordates and detail their mode of evolution among mammals...
  36. ncbi Replacement of asparagine with arginine at the extracellular end of the second transmembrane (M2) region of insect GABA receptors increases sensitivity to penicillin G
    Alastair M Hosie
    Department of Pharmacology, University College, Gower St, London WC1E 6BT, UK
    Invert Neurosci 6:75-9. 2006
    ..The A301S mutation that confers resistance to dieldrin did not significantly affect the antagonism by PCG...
  37. pmc Glutamate and GABA receptors and transporters in the basal ganglia: what does their subsynaptic localization reveal about their function?
    A Galvan
    Yerkes National Primate Research Center, Emory University, Atlanta, GA 30322, USA
    Neuroscience 143:351-75. 2006
    ....
  38. pmc Differential engagements of glutamate and GABA receptors in cardiovascular actions of endogenous nNOS or iNOS at rostral ventrolateral medulla of rats
    Samuel H H Chan
    Center for Neuroscience, National Sun Yat Sen University, Kaohsiung 80424, Taiwan, Republic of China
    Br J Pharmacol 138:584-93. 2003
    ..In addition, whereas NO derived from nNOS induced sympathoexcitation via both NMDA and non-NMDA receptors in the RVLM, NO generated by iNOS elicited sympathoinhibition via GABA(A) receptors...
  39. ncbi Roles of glutamate and GABA receptors in setting the developmental timing of spontaneous synchronized activity in the developing mouse cortex
    Annette K McCabe
    Department of Biology, University of Washington, Seattle, Washington 98195, USA
    Dev Neurobiol 67:1574-88. 2007
    ..GABA(A) inhibitors restore SSA in control slices, indicating that the emergence of GABA(A)-mediated inhibition is another major factor that helps terminate SSA...
  40. ncbi Neuroprotection against Abeta and glutamate toxicity by melatonin: are GABA receptors involved?
    Andrea C Paula-Lima
    Departamento de Bioquimica Medica, Instituto de Ciencias Biomedicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ 21941 590, Brazil
    Neurotox Res 5:323-7. 2003
    ..could be at least in part related to a decrease in the excitatory tonus, mediated by activation of GABA receptors and the resulting hyper-polarization of the neurons...
  41. pmc Long-term sensory deprivation selectively rearranges functional inhibitory circuits in mouse barrel cortex
    Peijun Li
    Department of Pharmacology, Georgetown University Medical Center, Washington, DC 20057, USA
    Proc Natl Acad Sci U S A 106:12156-61. 2009
    ....
  42. ncbi GABAergic modulation of the activity of globus pallidus neurons in primates: in vivo analysis of the functions of GABA receptors and GABA transporters
    Adriana Galvan
    Department of Neurology, Emory University, Atlanta, GA 30322, USA
    J Neurophysiol 94:990-1000. 2005
    ..The effects of GABA on pallidal activity depend on the synaptic localization of GABA receptors and the distribution and activity of GABA transporters (GATs)...
  43. ncbi Co-activation of GABA receptors inhibits the JNK3 apoptotic pathway via the disassembly of the GluR6-PSD95-MLK3 signaling module in cerebral ischemic-reperfusion
    Dong Han
    Research Center for Biochemistry and Molecular Biology, Xuzhou Medical College, Xuzhou, Jiangsu 221002, People s Republic of China
    FEBS Lett 582:1298-306. 2008
    ..Our results suggest that stimulation of the inhibitory GABA receptors can attenuate the excitatory JNK3 apoptotic signaling pathway via inhibiting the increased assembly of the ..
  44. ncbi The protein MAP-1B links GABA(C) receptors to the cytoskeleton at retinal synapses
    J G Hanley
    Department of Pharmacology, University College, London, UK
    Nature 397:66-9. 1999
    ..Our observations suggest a novel mechanism for localizing ionotropic GABA receptors to synaptic sites...
  45. ncbi Mapping the rho1 GABA(C) receptor agonist binding pocket. Constructing a complete model
    Anna Sedelnikova
    Departments of Neurobiology and Physiology and Biophysics, The Center for Biophysical Sciences and Engineering, University of Alabama at Birmingham, 35294, USA
    J Biol Chem 280:1535-42. 2005
    ..Combined with previous findings, a complete model of the GABA(C) receptor binding pocket was proposed and discussed in comparison with the GABA(A) receptor binding pocket...
  46. ncbi Bidirectional plasticity in fast-spiking GABA circuits by visual experience
    Yoko Yazaki-Sugiyama
    CREST, JST, Toyonaka, Osaka 560 0082, Japan
    Nature 462:218-21. 2009
    ..Together these results suggest that the bidirectional recruitment of an initially binocular GABA circuit may contribute to experience-dependent plasticity in the developing visual cortex...
  47. ncbi Fast synaptic currents in Drosophila mushroom body Kenyon cells are mediated by alpha-bungarotoxin-sensitive nicotinic acetylcholine receptors and picrotoxin-sensitive GABA receptors
    Hailing Su
    Department of Anatomy and Neurobiology, University of California Irvine, Irvine, California 92697 1280, USA
    J Neurosci 23:9246-53. 2003
    ..Fast IPSCs are mediated by picrotoxin-sensitive chloride conducting GABA receptors. The miniature IPSCs also have a rapid rate of rise and decay and a broad amplitude distribution...
  48. ncbi Modulation of ionotropic GABA receptors by natural products of plant origin
    Graham A R Johnston
    Department of Pharmacology, The University of Sydney, NSW, 2006, Australia
    Adv Pharmacol 54:285-316. 2006
  49. ncbi GABA(C) receptors: a molecular view
    R Enz
    Emil-Fischer Zentrum, , , Erlangen, Germany
    Biol Chem 382:1111-22. 2001
    ..Three types of GABA receptors have been identified on the basis of their pharmacological and electrophysiological properties...
  50. ncbi Allopregnanolone analogs that positively modulate GABA receptors protect against partial seizures induced by 6-Hz electrical stimulation in mice
    Rafal M Kaminski
    Epilepsy Research Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 4457, U S A
    Epilepsia 45:864-7. 2004
    ....
  51. ncbi Homomeric RDL and heteromeric RDL/LCCH3 GABA receptors in the honeybee antennal lobes: two candidates for inhibitory transmission in olfactory processing
    Julien Pierre Dupuis
    Centre de Recherches sur la Cognition Animale, Universite Paul Sabatier Toulouse III, CNRS UMR 5169, 118 route de Narbonne, Toulouse Cedex 9, France
    J Neurophysiol 103:458-68. 2010
    ..calcium concentration potentiated GABA-elicited currents, suggesting a modulating effect of calcium on GABA receptors possibly through phosphorylation processes that remain to be determined...
  52. ncbi St John's wort (Hypericum perforatum) modulates evoked potentials in guinea pig hippocampal slices via AMPA and GABA receptors
    Jens M Langosch
    Department of Psychiatry, University of Freiburg, Hauptstrasse 5, D 79104 Freiburg, Germany
    Eur Neuropsychopharmacol 12:209-16. 2002
    ..Hypericin and hyperforin, two components of H. perforatum, were found not to be responsible for the excitatory effects of the extract...
  53. ncbi Stress and GABA receptors
    Kelly J Skilbeck
    Department of Pharmacology, University of Sydney, Sydney, New South Wales, Australia
    J Neurochem 112:1115-30. 2010
    ..The short- and long-term stress sensitivity of the GABAergic system implicates GABA(A) receptors in the non-genetic etiology of psychiatric illnesses such as depression and schizophrenia in which stress may be an important factor...
  54. ncbi Prolonged reciprocal signaling via NMDA and GABA receptors at a retinal ribbon synapse
    Jozsef Vigh
    The Vollum Institute, Oregon Health and Science University, Portland, Oregon 97239, USA
    J Neurosci 25:11412-23. 2005
    ....
  55. ncbi Coactivation of GABA receptors inhibits the JNK3 apoptotic pathway via disassembly of GluR6-PSD-95-MLK3 signaling module in KA-induced seizure
    Chong Li
    Research Center of Biochemistry and Molecular Biology, Provincial Key Laboratory of Brain Disease Bioinformation, Xuzhou Medical College, Xuzhou, Jiangsu, China
    Epilepsia 51:391-403. 2010
    ....
  56. ncbi Disinhibition of spinal responses to primary afferent input by antagonism at GABA receptors in urethane-anaesthetised rats is dependent on NMDA and metabotropic glutamate receptors
    Itsaso Buesa
    Department of Neurosciences, School of Medicine and Dentistry, Basque Country University, Barrio Sarriena s n, 48940 Leioa, Spain
    Neuropharmacology 50:585-94. 2006
    ....
  57. ncbi GABA receptors, progesterone and premenstrual dysphoric disorder
    I Sundstrom Poromaa
    Department of Clinical Sciences, Obstetrics and Gynecology, Umea University, Umea, Sweden
    Arch Womens Ment Health 6:23-41. 2003
    ..These data are reviewed in the light of human clinical studies and specific animal models of PMDD...
  58. pmc Role of GABA receptors in nitric oxide inhibition of dorsolateral periaqueductal gray neurons
    Jihong Xing
    Heart and Vascular Institute and Department of Medicine, The Pennsylvania State University College of Medicine, Milton S Hershey Medical Center, Hershey, PA 17033, USA
    Neuropharmacology 54:734-44. 2008
    ..The purpose of this report was to investigate the role of GABA receptors in NO modulation of neuronal activity through inhibitory and excitatory synaptic inputs within the ..
  59. ncbi General anaesthesia: from molecular targets to neuronal pathways of sleep and arousal
    Nicholas P Franks
    Blackett Laboratory Biophysics Section, Imperial College, South Kensington, London, SW7 2AZ, UK
    Nat Rev Neurosci 9:370-86. 2008
    ..Recent work suggests that the thalamus and the neuronal networks that regulate its activity are the key to understanding how anaesthetics cause loss of consciousness...
  60. ncbi A cation-pi binding interaction with a tyrosine in the binding site of the GABAC receptor
    Sarah C R Lummis
    Department of Biochemistry, University of Cambridge, UK
    Chem Biol 12:993-7. 2005
    ..Comparisons among four homologous receptors show variations in cation-pi binding energies that reflect the nature of the cationic center of the agonist...
  61. pmc Drosophila melanogaster GRD and LCCH3 subunits form heteromultimeric GABA-gated cation channels
    Gunter Gisselmann
    Lehrstuhl fur Zellphysiologie, Ruhr Universitat Bochum, Universitatsstrasse 150, 44780 Bochum, Germany
    Br J Pharmacol 142:409-13. 2004
    ..The benzodiazepines flunitrazepam and diazepam did not potentiate the GABA-evoked current. Our data suggest that heteromultimeric channels composed of GRD and LCCH3 subunits form GABA-gated cation channels in insects...
  62. ncbi Desensitization mechanism of GABA receptors revealed by single oocyte binding and receptor function
    Yongchang Chang
    Department of Neurobiology and Physiology, University of Alabama at Birmingham, Birmingham, Alabama 35294 0021, USA
    J Neurosci 22:7982-90. 2002
    ..oocyte 3H-ligand binding and two-electrode voltage clamp to oocytes expressing recombinant alpha1beta2gamma2 GABA receptors. Using this approach, we report several observations fundamental to the mechanism of desensitization...
  63. ncbi Locating the carboxylate group of GABA in the homomeric rho GABA(A) receptor ligand-binding pocket
    Neil J Harrison
    Department of Biochemistry, University of Cambridge, Cambridge CB2 1QW, United Kingdom
    J Biol Chem 281:24455-61. 2006
    ....
  64. ncbi GABA and glutamate receptors are involved in modulating pacemaker activity in hydra
    G Kass-Simon
    Department of Biological Sciences, University of Rhode Island, Kingston, RI 02881, USA
    Comp Biochem Physiol A Mol Integr Physiol 136:329-42. 2003
    ..On the whole GABA decreased the outputs of both ectodermal and endodermal impulse generating systems, while glutamate increased them...
  65. ncbi Pentobarbital depressant effects are independent of GABA receptors in auditory thalamic neurons
    Xiang Wan
    Department of Pharmacology and Therapeutics and Department of Anesthesia, The University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada
    J Neurophysiol 88:3067-77. 2002
    ..The depressant effects of pentobarbital did not involve known types of GABA receptor interactions...
  66. ncbi Modulation by brain natriuretic peptide of GABA receptors on rat retinal ON-type bipolar cells
    Yong Chun Yu
    Institute of Neurobiology, Fudan University, Shanghai 200433, China
    J Neurosci 26:696-707. 2006
    ..We therefore conclude that the increased calcium release from ryanodine-sensitive calcium stores by BNP may be responsible for the BNP-caused GABAA response suppression in ON-type BCs through stimulating calmodulin...
  67. ncbi Functional evidence for a role of GABA receptors in modulating nerve activities of circular smooth muscle from rat colon in vitro
    Sophie Bayer
    INSERM Unit 338 Groupe de Neurogastroentérologie Pavillon Poincaré Hôpital Civil, 67000, Strasbourg, France
    Life Sci 72:1481-93. 2003
    ..Finally, it is shown for the first time the presence of the GABA vesicular transporter (VIAAT) around myenteric ganglia of rat colon...
  68. ncbi Evidence for a functional role of GABA receptors in the rat mature hippocampus
    Anniina Alakuijala
    Institute of Biotechnology, PO Box 56, FI 00014 University of Helsinki, Finland
    Eur J Neurosci 23:514-20. 2006
    ..The lack of GABA(C) receptor activation by less intensive stimulation under control conditions suggests that these receptors are extrasynaptic and activated via spillover of synaptically released GABA...
  69. ncbi Acetylcholine binding protein (AChBP): a secreted glial protein that provides a high-resolution model for the extracellular domain of pentameric ligand-gated ion channels
    Titia K Sixma
    Division of Molecular Carcinogenesis, Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    Annu Rev Biophys Biomol Struct 32:311-34. 2003
    ..7 A AChBP structure. The structural template provides critical details of the binding site and helps create models for toxin binding, mutational effects, and molecular gating...
  70. ncbi Ionotropic GABA receptors with mixed pharmacological properties of GABAA and GABAC receptors
    Kristin Hartmann
    Johannes Müller Institut für Physiologie, Universitatsklinikum Charite, Humboldt Universitat Berlin, Tucholskystrasse 2, 10117 Berlin, Germany
    Eur J Pharmacol 497:139-46. 2004
    ..We have characterized a distinct new type of GABA receptors in CA1 pyramidal cells in rat hippocampal slices...
  71. ncbi Medicinal chemistry and molecular pharmacology of GABA(C) receptors
    Graham A R Johnston
    Adrien Albert Laboratory of Medicinal Chemistry, Department of Pharmacology, The University of Sydney, Sydney, NSW, 2006, Australia
    Curr Top Med Chem 2:903-13. 2002
    ..The most useful currently available ligands that show some GABA(C) receptor subtype selectivity are TPMPA, P4PMA, imidazole-4-acetic acid, 2-methyl-TACA and (+/-)-TAMP...
  72. ncbi Density and distribution of hippocampal neurotransmitter receptors in autism: an autoradiographic study
    G J Blatt
    Neurobiology of Developmental Disorders Laboratory, Department of Anatomy and Neurobiology, Boston University School of Medicine, MA 02118, USA
    J Autism Dev Disord 31:537-43. 2001
    ....
  73. ncbi Functional and molecular analysis of GABA receptors in human midbrain-derived neural progenitor cells
    Florian Wegner
    Department of Neurology, University of Leipzig, Leipzig, Germany
    J Neurochem 107:1056-69. 2008
    ..These data indicate that NPCs derived from human fetal midbrain tissue acquire essential GABA(A) receptor properties during neuronal maturation in vitro...
  74. ncbi High-resolution quantitative visualization of glutamate and GABA receptors at central synapses
    Miwako Masugi-Tokita
    Division of Cerebral Structure, National Institute for Physiological Sciences, Myodaiji, Okazaki 444 8787, Japan
    Curr Opin Neurobiol 17:387-93. 2007
    ..The two-dimensional view and high sensitivity of SDS-FRL have revealed small, irregularly shaped AMPA receptor clusters within cerebellar synapses...
  75. ncbi Identification of major phylogenetic branches of inhibitory ligand-gated channel receptors
    H Xue
    Department of Biochemistry, Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong
    J Mol Evol 47:323-33. 1998
    ....
  76. ncbi Ligands of the mitochondrial 18 kDa translocator protein attenuate apoptosis of human glioblastoma cells exposed to erucylphosphohomocholine
    Wilfried Kugler
    Abteilung Pädiatrie I, Zentrum Kinderheilkunde und Jugendmedizin, Universitätsklinikum Göttingen, D 37075 Gottingen, Germany
    Cell Oncol 30:435-50. 2008
    ....
  77. ncbi CoCl(2) induces apoptosis via the 18 kDa translocator protein in U118MG human glioblastoma cells
    Sivan Zeno
    Rappaport Family Institute for Research in the Medical Sciences, Technion Israel Institute of Technology, Department of Molecular Pharmacology, Ephron Street, P O Box 9649, Bat Galim, Haifa 31096, Israel
    Biochemistry 48:4652-61. 2009
    ..In conclusion, our studies show that activation of TSPO by CoCl(2) application is required for ROS generation, leading to cardiolipin oxidation, and collapse of the Deltapsi(m), as induced by CoCl(2)...
  78. ncbi Channel-like functions of the 18-kDa translocator protein (TSPO): regulation of apoptosis and steroidogenesis as part of the host-defense response
    Leo Veenman
    Department of Pharmacology, Rappaport Family Institute for Research in the Medical Sciences, Technion Israel Institute of Technology, Haifa, Israel
    Curr Pharm Des 13:2385-405. 2007
    ....
  79. ncbi Serotonin transporter (5-HTT) and gamma-aminobutyric acid receptor subunit beta3 (GABRB3) gene polymorphisms are not associated with autism in the IMGSA families. The International Molecular Genetic Study of Autism Consortium
    E Maestrini
    The Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    Am J Med Genet 88:492-6. 1999
    ..No significant evidence of association or linkage was found at any of the markers tested, indicating that the 5-HTT and the GABRB3 genes are unlikely to play a major role in the aetiology of autism in our family data set...
  80. pmc Chloride channels of glycine and GABA receptors with blockers: Monte Carlo minimization and structure-activity relationships
    B S Zhorov
    INSERM U 261 Neurobiologie Cellulaire, Institut Pasteur, Paris, France
    Biophys J 78:1786-803. 2000
    ..This analysis provides explanations for structure-activity relationships of noncompetitive agonists and predicts a narrow pore of LGICs in agreement with experimental data on the permeation of organic cations...
  81. ncbi Activation of GABA receptors attenuates neuronal apoptosis through inhibiting the tyrosine phosphorylation of NR2A by Src after cerebral ischemia and reperfusion
    F Zhang
    Research Center for Biochemistry and Molecular Biology and Provincial Key Laboratory of Brain Disease Bioinformation, Xuzhou Medical College, 84 West Huai hai Road, Xuzhou 221002, Jiangsu, China
    Neuroscience 150:938-49. 2007
    ..immunoprecipitation and histology analysis to evaluate the neuroprotective effects by stimulating GABA receptors in rat four-vessel occlusion (4-VO) ischemic model, and to investigate the potential mechanism...
  82. pmc Functional role of GABAergic innervation of the cochlea: phenotypic analysis of mice lacking GABA(A) receptor subunits alpha 1, alpha 2, alpha 5, alpha 6, beta 2, beta 3, or delta
    Stephane F Maison
    Department of Otology and Laryngology, Harvard Medical School and Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA
    J Neurosci 26:10315-26. 2006
    ..Results suggest that the GABAergic component of the olivocochlear system contributes to the long-term maintenance of hair cells and neurons in the inner ear...
  83. ncbi Subplate neurons regulate maturation of cortical inhibition and outcome of ocular dominance plasticity
    Patrick O Kanold
    Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA
    Neuron 51:627-38. 2006
    ..Thus, subplate neurons regulate molecular machinery required to establish an adult balance of excitation and inhibition in layer 4, and thereby influence the outcome of OD plasticity...
  84. ncbi The 18-kDa translocator protein, formerly known as the peripheral-type benzodiazepine receptor, confers proapoptotic and antineoplastic effects in a human colorectal cancer cell line
    Rami Shoukrun
    Rappaport Family Institute for Research in the Medical Sciences, Technion Israel Institute of Technology, Haifa, Israel
    Pharmacogenet Genomics 18:977-88. 2008
    ..In-vivo TSPO involvement in tumor growth of HT29 cells xenografted into SCID mice was studied...
  85. ncbi Identification of a putative gamma-aminobutyric acid (GABA) receptor subunit rho2 cDNA and colocalization of the genes encoding rho2 (GABRR2) and rho1 (GABRR1) to human chromosome 6q14-q21 and mouse chromosome 4
    G R Cutting
    Center for Medical Genetics, Johns Hopkins University School of Medicine, Baltimore, Maryland
    Genomics 12:801-6. 1992
    ..This close physical association and high degree of sequence similarity raises the possibility that one rho gene arose from the other by duplication...
  86. pmc Modeling neuronal nicotinic and GABA receptors: important interface salt-links and protein dynamics
    Richard J Law
    Biosciences and Biotechnology Division, Physical and Life Sciences Directorate, Lawrence Livermore National Laboratory, Livermore, California, USA
    Biophys J 97:1586-94. 2009
    ..Homology models of the alpha4beta2 nicotinic acetylcholine (nACh) and beta2alpha1gamma2 GABA receptors were constructed based on the torpedo neuromuscular-like nicotinic receptor structure...
  87. ncbi Stable expression of a functional homo-oligomeric Drosophila GABA receptor in a Drosophila cell line
    N S Millar
    Wellcome Laboratory of Molecular Pharmacology, Department of Pharmacology, University College London, U K
    Proc Biol Sci 258:307-14. 1994
    ..The suitability of this Drosophila stable expression system for the characterization of receptors and ion channels is discussed...
  88. ncbi GABA receptors inhibited by benzodiazepines mediate fast inhibitory transmission in the central amygdala
    A J Delaney
    Division of Neuroscience, John Curtin School of Medical Research, Australian National University, Canberra ACT 2601, Australia
    J Neurosci 19:9698-704. 1999
    ..We conclude that a new type of ionotropic GABA receptor mediates fast inhibitory transmission in the central amygdala. This receptor may be a potential target for the development of new therapeutic strategies for anxiety disorders...
  89. ncbi Glycine and GABA receptors in the mammalian retina
    H Wassle
    Max Planck Institut für Hirnforschung, Frankfurt, Germany
    Vision Res 38:1411-30. 1998
    ..In conclusion we find a great diversity of glycine and GABA receptors in the mammalian retina, which might match the plethora of morphological types of amacrine cells...
  90. ncbi H(2)O(2) opens mitochondrial K(ATP) channels and inhibits GABA receptors via protein kinase C-epsilon in cardiomyocytes
    Hong Yan Zhang
    Department of Anesthesiology, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Am J Physiol Heart Circ Physiol 282:H1395-403. 2002
    ..In addition, PKC, mitochondrial ATP-sensitive K(+) (K(ATP)) channels, and GABA receptors had no effects on H(2)O(2) generated by ischemic preconditioning before prolonged hypoxia and reoxygenation...
  91. pmc Allosteric modulation of an expressed homo-oligomeric GABA-gated chloride channel of Drosophila melanogaster
    A M Hosie
    Department of Zoology, University of Cambridge
    Br J Pharmacol 117:1229-37. 1996
    ..of barbiturates and steroids on RDL homo-oligomers resemble those observed for several in situ insect GABA receptors, whereas those of benzodiazepine binding-site ligands are considerably reduced...
  92. ncbi Secondary and tertiary structures of the transmembrane domains of the translocator protein TSPO determined by NMR. Stabilization of the TSPO tertiary fold upon ligand binding
    Samuel Murail
    Commissariat a l Energie Atomique, Centre de Saclay, Institut de Biologie et Technologies de Saclay and URA CNRS 2096, Service de Bioénergétique Biologie Structurale et Mécanismes, Gif sur Yvette Cedex, France
    Biochim Biophys Acta 1778:1375-81. 2008
    ..They reveal that the binding of a drug ligand that stimulates cholesterol translocation is able to stabilize the mTSPO tertiary structure...
  93. ncbi Adenosine A1 receptors inhibit GABAergic transmission in rat tuberomammillary nucleus neurons
    Do Seop Yum
    Department of Pharmacology, School of Dentistry, Kyungpook National University, Daegu, Republic of Korea
    J Neurochem 106:361-71. 2008
    ....
  94. ncbi Pharmacology of GABAC receptors: responses to agonists and antagonists distinguish A- and B-subtypes of homomeric rho receptors expressed in Xenopus oocytes
    Yi Pan
    Department of Ophthalmology and Visual Sciences, University of Illinois College of Medicine, 1855 West Taylor Street, Chicago, IL 60612, USA
    Neurosci Lett 376:60-5. 2005
    ..These results indicate that, in addition to the characteristic response properties identified previously, there is a pattern of pharmacological reactions that further distinguishes the A- and B-subtypes of GABA rho receptor...
  95. ncbi Dendritic morphology, local circuitry, and intrinsic electrophysiology of neurons in the rat medial and lateral habenular nuclei of the epithalamus
    Uhnoh Kim
    Department of Biomedical Sciences and Interdepartmental Neuroscience Program, College of Veterinary Medicine, Iowa State University, IA 50011 1250, USA
    J Comp Neurol 483:236-50. 2005
    ....
  96. ncbi Electrophysiological evidence of GABAA and GABAC receptors on zebrafish retinal bipolar cells
    Victoria P Connaughton
    Department of Biology, American University, Washington, DC 20016, USA
    Vis Neurosci 25:139-53. 2008
    ..In summary, axon terminals contain bicuculline-sensitive GABAA receptors and both picrotoxin-sensitive and insensitive GABAC receptors. Dendritic processes express zinc- and picrotoxin-sensitive GABAC receptors...
  97. ncbi Characterization of inhibitory postsynaptic currents in rod bipolar cells of the mouse retina
    Moritz J Frech
    Max Planck Institut für Hirnforschung, Neuroanatomical Department, Frankfurt am Main, Germany
    Vis Neurosci 21:645-52. 2004
    ....
  98. ncbi Periodic oscillatory activity in parahippocampal slices maintained in vitro
    T Kano
    Montreal Neurological Institute and Department of Neurology and Neurosurgery, McGill University, 3801 University Street, Room 794, Montreal, Quebec, H3A 2B4 Canada
    Neuroscience 130:1041-53. 2005
    ....
  99. ncbi Pontine GABAergic pathways: role and plasticity in the hypoxic ventilatory response
    Yee Hsee Hsieh
    Department of Pharmacology, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106 4965, USA
    Respir Physiol Neurobiol 143:141-53. 2004
    ..These physiological and molecular results illustrate the importance of pontine GABAergic pathways in shaping the response to hypoxia...
  100. pmc Peripheral GABAB agonists stimulate gastric acid secretion in mice
    Laura Piqueras
    Department of Physiology, Pharmacology and Toxicology, Cardenal Herrera CEU University, Valencia, Spain
    Br J Pharmacol 142:1038-48. 2004
    ..Somatostatin implication might be secondary to the release of gastrin and the increase in gastric luminal acidity...
  101. pmc Ethanol dually modulates GABAergic synaptic transmission onto dopaminergic neurons in ventral tegmental area: role of mu-opioid receptors
    C Xiao
    Department of Anesthesiology, Physiology and Pharmacology, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, 185 South Orange Avenue, Newark, NJ 07103, USA
    Neuroscience 153:240-8. 2008
    ..This dual modulation of GABAergic transmission by ethanol may be an important mechanism underlying alcohol addiction...

Research Grants68

  1. Attenuating the retinal and CNS adverse effects of vigabatrin with NKCC1 inhibito
    Frances E Jensen; Fiscal Year: 2010
    ..Importantly, when NKCC1 is overexpressed relative to KCC2, Cl- will be high intracellularly and thus when GABA receptors are activated. Cl- will flow out of the cell, causing depolarization and excitation...
  2. GABA chaperoning of epilepsy-associated GABAA receptor mutants.
    Nancy J Leidenheimer; Fiscal Year: 2012
    ..The proposed research investigates a possible mechanism for aiding the correct synthesis of these mutant receptors. Thus, these studies have relevance to the treatment of epilepsy. ..
  3. GABA channels and dopamine in striatum
    Stefano Vicini; Fiscal Year: 2013
    ..Previous reports have suggested that dopamine depletion induces changes in GABA receptors which exacerbate this imbalance of striatal output...
  4. Quantitative Comparisons between genotypes and model species
    Lauren M McIntyre; Fiscal Year: 2013
    ..In addition, we will determine how robust these predictions are to gene by environment effects by exposing both populations to ethanol. ..
  5. ADOLESCENT ANABOLIC STEROIDS, VASOPRESSIN AND AGGRESSION
    Richard H Melloni; Fiscal Year: 2013
    ..will ask three questions: (1) does adolescent anabolic steroid exposure affect the activity of select DA and GABA receptors in the LAH and does DA and GABA signaling through these receptors modulate LAH AVP release/activity and ..
  6. Presynaptic GABA-A receptor activation in auditory brainstem axon terminals
    CATHERINE JEANNE CHALENSKI WEISZ; Fiscal Year: 2013
    ..to investigate the subcellular structures at the synapses between MNTB and LSO neurons in order to measure how GABA receptors are involved in the proper formation of synapses between the MNTB and LSO...
  7. The role of GABAB signaling during axon guidance in the developing zebrafish
    ALEMJI TAKU; Fiscal Year: 2011
    ..By investigating the role the GABAB receptor plays in axon guidance, we may elucidate normal developmental processes and provide valuable insight into the pathogenesis and treatment of neurodevelopmental and neurodegenerative diseases. ..
  8. Reversal of T1D in NOD mice using a safe combination therapy
    Daniel Kaufman; Fiscal Year: 2013
    ..We also expect to identify new pharmacological approaches to help expand Tregs and modulate effector T cells and APCs in ways that will be beneficial for inhibiting T1D as well as other T-cell mediated autoimmune diseases. ..
  9. Vasopressin in the regulation of serotonin and anxiety
    BENJAMIN DAVID ROOD; Fiscal Year: 2013
    ..abstract_text> ..
  10. The Role of Genome-Coded ME2 in Epilepsy
    David A Greenberg; Fiscal Year: 2010
    ..Anti-epilepsy drug mechanisms also modulate the GABA neurotransmitter system, and mutations in GABA receptors have been shown to play a role in susceptibility to some forms of epilepsy...
  11. ROLE OF INHIBITION WITHIN THE CEREBELLAR NODULUS/UVULA IN VESTIBULAR PROCESSING
    TATYANA ALEKSANDROVNA YAKUSHEVA; Fiscal Year: 2012
    ..on studying the effect of blocking GABA-A and GABA-B receptors because they are the most common forms of GABA receptors in the cerebellar cortex...
  12. X-linked Genes, Histone Modifications, and Behavior
    Jun Xu; Fiscal Year: 2013
    ..In mice, aggression is influenced by both steroid hormones and sex chromosomes. We propose to test the possible connection between aggression and an X-linked gene whose mutations in human cause the clinical feature of aggression. ..
  13. GABA-B Receptor Modulation of Calcium Currents
    Michelle Mynlieff; Fiscal Year: 2010
    ..Pharmaceutical compounds that interact with GABA receptors are routinely prescribed for anxiety, epilepsy, insomnia, etc...
  14. The Role of Mpdz in Ethanol Withdrawal and Genetically Correlated Behaviors
    Kari J Buck; Fiscal Year: 2012
    ..Given that Mpdz encodes a protein that regulates the function of serotonin and GABA receptors in the brain, and dysregulation of serotonin and GABA function contributes to alcoholism, we expect that the ..
  15. Novel, subtype selective potentiators of nicotinic acetycholine receptors
    MARVIN KENNETH SCHULTE; Fiscal Year: 2010
    ..data indicates a putative binding site at a subunit interface equivalent to the benzodiazepine binding site of GABA receptors and we have identified an improved dFBr analog in our preliminary synthetic studies that retains the ability ..
  16. GABA Receptors and Hilar Neuron Survival in Epilepsy
    Carolyn R Houser; Fiscal Year: 2013
    ..By allowing selective manipulation of hilar neurons in the intact brain, these studies will provide unique views of their function within normal and altered neuronal circuits. ..
  17. Continuous OC Treatment in PMDD: Steroid Hormone Mechanisms
    David R Rubinow; Fiscal Year: 2012
    ..abstract_text> ..
  18. The NKCC1 inhibitor bumetanide as a novel therapy in TSC
    Frances E Jensen; Fiscal Year: 2013
    ..Develop new animal models to study epileptogenesis. Area II. Develop new treatment strategies and improve current approaches in order to cure epilepsy C. Improve current treatments and develop new technologies ..
  19. Molecular Determinants of GABAA Receptor Gene Regulation
    SHELLEY JUNE RUSSEK; Fiscal Year: 2010
    ..Using viral-mediated delivery of RNAi to target both endogenous Egr3 and GABRA4 gene expression, we will test whether increased alpha-4 subunits are required for development of spontaneous seizures in TLE rats. ..
  20. PEDIATRIC PHARMACOLOGY RESEARCH UNIT
    Mary Lieh Lai; Fiscal Year: 2009
    ..2) To determine the ontogeny of GABA receptors and to develop innovative pharmacotherapies of neonatal and childhood diseases such as neonatal apnea, ..
  21. GABAergic and Reelin Deficits in Schizophrenia
    SEYYED HOSSEIN FATEMI; Fiscal Year: 2013
    ..major depression, and matched controls;2) Determine the mRNA and protein levels of GAD65, GAD67, and selected GABA receptors in frontal cortex, anterior hippocampus, and lateral cerebellum of subjects with schizophrenia vs...
  22. Sex dependent astrocyte activation and alcohol-induced neurotoxicity
    Kristine M Wiren; Fiscal Year: 2010
    ..b>GABA receptors are also a target of neuroadaptation to chronic EtOH abuse, and have been implicated in astrocyte function...
  23. Mechanisms Underlying Activity-Dependent Interneuron Development
    NATALIA VANESA DE MARCO GARCIA; Fiscal Year: 2013
    ..To assess the role of GABA in radial migration, GABA receptors will be blocked pharmacologically (Subaim 1b)...
  24. Structural investigation of a GABA receptor subtype
    DEREK CLAXTON; Fiscal Year: 2013
    ..The results of this work will substantially contribute to the understanding of GABAA receptor structure and the allosteric effects of ligand binding on channel behavior. ..
  25. Effects of Advanced EA on Hypertension: Role of nNOS-NO in the Dorsal Medulla
    Sheng Xing Ma; Fiscal Year: 2010
    ..NO donors on the hypotensive responses to EA ST36 are inhibited by microinjection of either an antagonist of GABA receptors or an ihhibitor of guanylyl cyclase into gracile nucleus...
  26. Mechanisms of Intercelllar Communication
    VYTAUTAS K VERSELIS; Fiscal Year: 2013
    ..Trainees are encouraged to take full advantage of the multiplicity of scientific opportunities in the College as a whole. RELEVANCE (See instructions): ..
  27. Perisomatic Inhibitory Network Dysfunction in Neurological Disease
    Vijayalakshmi Santhakumar; Fiscal Year: 2013
    ..regulated during seizures will help evaluate whether pharmacological manipulation of gap junctions and GABA receptors would be effective in treating epilepsy...
  28. Anesthetic actions on GABA(A) fast, slow, tonic and GABA(B) receptors
    M Bruce MacIver; Fiscal Year: 2013
    ..aims is essential for designing safer and more effective anesthetics that selectively target the most relevant GABA receptors. In the immediate-term, we will contribute quantitative assessments to resolve current controversies, and ..
  29. New Methods for the Expedited Synthesis of C11 and F18 PET Tracers
    Salvatore D Lepore; Fiscal Year: 2013
    ..radio synthesis of [11C] baclofen (and related analogs for better brain permeation) is expected to facilitate future PET studies of GABA receptors and ultimately lead to improved therapies for diseases related to these receptors.
  30. Role of zinc in regulating axo-dendritic chloride following status epilepticus
    Daniel L Jones; Fiscal Year: 2011
    ..low concentrations of chloride inside neurons, allowing for hyperpolarization when chloride- permeable GABA receptors are activated...
  31. GABA Channel Activation Domains and Mechanisms
    David S Weiss; Fiscal Year: 2013
    ..Furthermore, GABA receptors are targets for a host of therapeutic and endogenous modulators such as benzodiazepines, barbiturates, and ..
  32. GABA(A) Receptor Complex In Alcohol Dependence
    Richard W Olsen; Fiscal Year: 2012
    ..The amounts, locations, and functions of the GABA receptors are related to the behavioral changes seen in alcohol dependence such as hyperexcitability, increased anxiety, ..
  33. Anatomical and Physiological Characterization of the Thalamostriatal System
    KALYNDA GONZALES; Fiscal Year: 2012
    ..The results will also be relevant for our understanding of the mechanisms underlying the therapeutic effects of CM/PF DBS in movement disorders. ..
  34. Unique pharmacology of ligand sites on delta subunit-containing GABA-A receptors
    Martin Wallner; Fiscal Year: 2013
    ..photoaffinity will allow the identification of amino acid residues in the EtOH/Ro15-4513 binding site on delta GABA receptors. Based on a detailed structural model hypothesis, the exact amino acid residues that form the alcohol site on ..
  35. Genetic modifiers of tobacco dependence treatment response in zebrafish
    Margot Cousin; Fiscal Year: 2013
    ....
  36. Behavioral Neurobiology of Aggression, Alcohol, GABA, and 5-HT
    Klaus A Miczek; Fiscal Year: 2013
    ..The anticipated outcome will identify targets for therapeutic interventions. ..
  37. Structural dynamics underlying rho1 GABAC receptor activation and antagonism
    Yongchang Chang; Fiscal Year: 2013
    ..findings also will provide a structural basis for development of new therapeutics or research tools targeting GABA receptors. PUBLIC HEALTH RELEVANCE: This project seeks to provide new insights into structural basis for the mechanism ..
  38. Endogenous GABAergic Activity
    Istvan Mody; Fiscal Year: 2013
    ..g., striatal medium spiny neurons, MSNs). The receptors for GABA are also diverse and specific. Ligand-gated GABA receptors (GABAARs), members of the Cys-loop receptor family, are present on virtually every neuron in the brain and ..
  39. Neural synchronydysfunction of gamma oscillations in autism
    Donald C Rojas; Fiscal Year: 2013
    ..Gamma band oscillatory activity has been associated with intrinsic GABAergic activity in animal and computational models of the neocortex and is thought to play an important role in binding and central coherence ..
  40. A novel developmental mouse model of major depressive disorder
    Bernhard Luscher; Fiscal Year: 2013
    ..most pronounced in the melancholic subtype of MDD, and alterations in the subunit composition of the principal GABA receptors (GABAARs)...
  41. Simulation of learning: models and biological validation
    Michel Baudry; Fiscal Year: 2012
    ..Finally, integrating various GABA receptors will provide a unique tool to better understand the effects of a large number of drugs currently used to treat ..
  42. Neuroprotection by Allopregnanolone through Modulation of GABAA Receptors
    MELISSA HERNANDEZ KELLEY; Fiscal Year: 2010
    ....
  43. The amino-terminal domain guides subfamily-specific assembly of ionotropic glutam
    Rongsheng Jin; Fiscal Year: 2013
    ..such as potassium channels, cyclic nucleotide-gated channels, nicotinic acetylcholine receptors, GABA receptors and others...
  44. GABAergic Involvement in Caenorhabditis elegans Social Behavior
    JOSHUA SOLOMON GREENE; Fiscal Year: 2013
    ..The successful completion of these aims will provide a foundation to understand how social cues produce and maintain an altered behavioral state. ..
  45. GABA Deficits and Vulnerability to Cannabinoid-Induced Psychosis
    DEEPAK CYRIL D apos SOUZA; Fiscal Year: 2010
    ....
  46. Elucidation of the developmental role of Jakmip1, and autism-susceptibility gene
    JAMEE MAE BOMAR; Fiscal Year: 2012
    ..Secondly, JAKMIP1 regulates the expression and possible transport of GABA receptors and GABAergic systems are known to be abnormal in the autisms...
  47. Defining Alcohol Binding Sites in Ligand-Gated Ion Channels
    JAMES ROBERT TRUDELL; Fiscal Year: 2013
    ..In Aim 1, Trudell and Bertaccini will build computational models of alcohol-binding sites in GABA receptors and design site-directed mutations to test the models...
  48. The roles and mechanisms of GABA receptor activation in regulating neurogenesis i
    SHAOYU NONE GE; Fiscal Year: 2013
    ..acid (GABA), one of the major inhibitory neurotransmitter in the adult central nervous system, activates GABA receptors in the tonic/phasic mechanisms...
  49. Genetic network analysis of cancer targets
    William A Weiss; Fiscal Year: 2013
    ..We present preliminary data utilizing this methodology to identify GABA receptors as novel targets in medulloblasotma...
  50. ANESTHETIC MECHANISMS AND GABA-A RECEPTOR STRUCTURE
    MYLES AKABAS; Fiscal Year: 2001
    ..The extracellular domain of the GABA receptors contains residues that form the GABA and benzodiazepine binding sites...
  51. GABAERGIC INSECTICIDE TOXICOLOGY
    JOHN CASIDA; Fiscal Year: 2002
    ..Emphasis will be placed on the discovery of differences between the GABA receptors of mammals and insects that confer preferential sensitivity to insecticides and safety to mammals...
  52. Eszopiclone for the Treatment of PTSD
    Mark H Pollack; Fiscal Year: 2013
    ..Addressing these aims will help inform the treatment of PTSD and have important public health significance. ..
  53. FUNCTIONAL ANALYSIS OF NOVEL GABA RECEPTOR IN DROSOPHILA
    Richard ffrench Constant; Fiscal Year: 1999
    ..b>GABA receptors have been implicated in a number of human disorders and bursting responses from picrotoxinin (PTX) have been ..
  54. GABA-A Receptor Gene Transfer to Prevent Epileptogenesis
    SHELLEY RUSSEK; Fiscal Year: 2004
    ..abstract_text> ..
  55. REGULATION OF THE GABA RECEPTOR-CHLORIDE ION CHANNEL
    ROCHELLE SCHWARTZ BLOOM; Fiscal Year: 1991
    ..This research should reveal the importance of these mechanisms in the actions of convulsant and anticonvulsant drugs and in the physiology of seizure activity itself...
  56. ANXIETY--GABA RECEPTOR AND OPIOID GENE TRANSFER
    MARLENE WILSON; Fiscal Year: 2000
    ..It will thus help to elucidate the role(s) of specific, localized neurotransmitter functions in complex behaviors such as anxiety. ..
  57. GABAA RECEPTOR CHANNEL ALTERATION BY PROLONGED SEIZURES
    Robert MacDonald; Fiscal Year: 2003
    ....
  58. Genetic and neuronal regulation of sleep by adenosine in zebrafish
    DAVID AARON PROBER; Fiscal Year: 2013
    ..Furthermore, most drugs used to treat insomnia, the most common sleep disorder, act by inhibiting GABA receptors, which are relatively non-specific targets for sleep...
  59. Structural Studies of Metabotropic GABA Receptors
    Qing R Fan; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: Malfunction of metabotropic GABA receptors leads to neurological disorders in human...
  60. Effects of acupuncture on chemotherapy-induced pain
    Ruixin Zhang; Fiscal Year: 2009
    ..This study will evaluate the effects and mechanisms of electroacupuncture (EA) on such pain in a rat model. The success of the proposed study will greatly advance the management of CIP. ..
  61. CELLULAR MECHANISMS IN EPILEPTOGENESIS
    John R Huguenard; Fiscal Year: 2013
    ..contrast, multiple lines of evidence suggest that endogenous ligands for the benzodiazepine site of inhibitory GABA receptors, endozepines, are constitutively expressed in the thalamus to augment synaptic inhibition specifically in the ..
  62. Investigation of a Putative Alcohol Inhibitory Site on the GABAA Receptor
    W DAVID JOHNSON II; Fiscal Year: 2010
    ..Although there is strong evidence for molecular sites of alcohol action on GABA receptors that have been correlated with behavioral studies, alcohol effects on synaptic receptors often require supra- ..
  63. ROLE OF GABAERGIC NEURONS IN AUTONOMIC NUCLEI
    BANG HWANG; Fiscal Year: 1991
    ..LCV), and NTS; 2) to characterize GAD activities, GABA synaptogenesis, GABA contents, GABA turnover and GABA receptors in the PVN, LCV, and NTS of SHR rats; 3) to evaluate the relationship between GABA parameters and VP ..
  64. Endogenous GABAergic Activity
    Istvan Mody; Fiscal Year: 2007
    ..Moreover, the study will use genetically altered mice that over- or under-express certain GABA receptors in specific neuronal populations...
  65. CHEMICAL REACTIONS IN TRANSMISSION OF NERVE IMPULSES
    George Hess; Fiscal Year: 2004
    ..The ligands are isolated by a technique developed by the principal investigator's laboratory. ..
  66. A NOVEL CLASS OF MAMMALIAN GABA RECEPTOR
    Ricardo Miledi; Fiscal Year: 1993
    ..In mammals there are two well characterized families of GABA receptors. GABA-A receptors are ligand-gated Cl- channels, which are specifically antagonized by the convulsive alkaloid ..
  67. OPIOID GABA INTERACTIONS AND ANTINOCICEPTION
    Alexander Kalyuzhny; Fiscal Year: 2002
    ..Results of this study will contribute to our understanding of the mechanisms of opioid anti-nociception, and will suggest strategies for developing alterative, non-opioid, approaches for pain-treatment. ..
  68. REGION SPECIFIC PHOSPHOPROTEINS IN THE BASAL GANGLIA
    Paul Greengard; Fiscal Year: 2004
    ..gene knockout mice to evaluate the roles of PP1 isoforms, and neurabin in the phosphorylation of glutamate and GABA receptors. Project (Physiological and Cell Biological Studies of Phosphoproteins in the Basal Ganglia) will include: ..