Genomes and Genes
Summary: Receptors such as INTEGRIN ALPHAVBETA3 that bind VITRONECTIN with high affinity and play a role in cell migration. They also bind FIBRINOGEN; VON WILLEBRAND FACTOR; osteopontin; and THROMBOSPONDINS.
Publications189 found, 100 shown here
- Vitronectin and its receptorsB Felding Habermann
Department of Molecular and Experimental Medicine, Scripps Research Institute, La Jolla, California 92037
Curr Opin Cell Biol 5:864-8. 1993..protein vitronectin is recognized as an adhesive substrate by cells expressing at least one of four known vitronectin receptors: integrins alpha v beta 1, alpha v beta 3, alpha v beta 5 or alpha IIb beta 3...
- Solution structures and integrin binding activities of an RGD peptide with two isomersN Assa-Munt
Cancer Research Center, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA
Biochemistry 40:2373-8. 2001..Solution structure analysis by nuclear magnetic resonance reveals an entirely different presentation of the RGD motif in the two isomers of RGD-4C. These results provide new insight into the ligand recognition specificity of integrins...
- Adhesion and migration of extracellular matrix-stimulated breast cancerJohn E Bartsch
Department of Surgery, Medical College of Ohio, 3065 Arlington Avenue, Ohio 43614 5807, Toledo, USA
J Surg Res 110:287-94. 2003..We hypothesized that ECM binding to integrin receptors on breast cancer cells influenced cellular adhesion and migration...
- Biological and molecular properties of a new alpha(v)beta3/alpha(v)beta5 integrin antagonistLaura Belvisi
Organic and Industrial Chemistry Department, Centre for Biomolecular Interdisciplinary Studies and Industrial Applications, University of Milan, Italy
Mol Cancer Ther 4:1670-80. 2005..Taken together, these observations indicate that ST1646 represents a dual alpha(v)beta3/alpha(v)beta5 integrin antagonist with interesting biochemical and biological features to be tested in cancer therapy...
- Requirement of vascular integrin alpha v beta 3 for angiogenesisP C Brooks
Department of Immunology, Scripps Research Institute, La Jolla, CA 92037
Science 264:569-71. 1994..These findings suggest that alpha v beta 3 may be a useful therapeutic target for diseases characterized by neovascularization...
- Endothelial cell attachment and spreading on human tenascin is mediated by alpha 2 beta 1 and alpha v beta 3 integrinsP Sriramarao
La Jolla Institute for Experimental Medicine, CA 92037
J Cell Sci 105:1001-12. 1993....
- A signaling pathway from the alpha5beta1 and alpha(v)beta3 integrins that elevates bcl-2 transcriptionM L Matter
Cancer Research Center, The Burnham Institute, La Jolla, California 92037, USA
J Biol Chem 276:27757-63. 2001..Mitogen-activated protein kinase did not appear to be necessary for the activation of bcl-2 transcription. Therefore, our work characterizes the pathway that mediates the effect of integrins on bcl-2 transcription and cell survival...
- Src-mediated coupling of focal adhesion kinase to integrin alpha(v)beta5 in vascular endothelial growth factor signalingBrian P Eliceiri
Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
J Cell Biol 157:149-60. 2002..Our findings indicate that Src can coordinate specific growth factor and extracellular matrix inputs by recruiting integrin alpha(v)beta5 into a FAK-containing signaling complex during growth factor-mediated biological responses...
- Thrombospondin cooperates with CD36 and the vitronectin receptor in macrophage recognition of neutrophils undergoing apoptosisJ Savill
Department of Medicine, Royal Postgraduate Medical School, Hammersmith Hospital, London, United Kingdom
J Clin Invest 90:1513-22. 1992..Our findings indicate newly defined roles for TSP and CD36 in phagocytic clearance of senescent neutrophils, which may limit inflammatory tissue injury and promote resolution...
- Integrin alpha v beta 3 differentially regulates adhesive and phagocytic functions of the fibronectin receptor alpha 5 beta 1S D Blystone
Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110
J Cell Biol 127:1129-37. 1994..In addition to its significance for phagocytosis, alpha v beta 3 regulation of alpha 5 beta 1 function may be significant for its roles in cell migration, metastasis, and angiogenesis...
- Eta-1 (osteopontin): an early component of type-1 (cell-mediated) immunityS Ashkar
Laboratory for Skeletal Disorders and Rehabilitation, Department of Orthopedic Surgery, Children s Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA
Science 287:860-4. 2000..These findings identify Eta-1 as a key cytokine that sets the stage for efficient type-1 immune responses through differential regulation of macrophage IL-12 and IL-10 cytokine expression...
- Integrin-associated protein immunoglobulin domain is necessary for efficient vitronectin bead bindingF P Lindberg
Department of Infectious Diseases, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Cell Biol 134:1313-22. 1996..These data demonstrate that some alpha v integrin ligand-binding functions are IAP independent, whereas others require IAP, presumably through direct physical interaction between its Ig domain and the integrin...
- Integrin beta 3 cytoplasmic tail is necessary and sufficient for regulation of alpha 5 beta 1 phagocytosis by alpha v beta 3 and integrin-associated proteinS D Blystone
Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Cell Biol 130:745-54. 1995....
- Focal adhesion kinase signaling promotes phagocytosis of integrin-bound photoreceptorsSilvia C Finnemann
Dyson Vision Research Institute, Department of Ophthalmology, Weill Medical College of Cornell University, New York, NY 10021, USA
EMBO J 22:4143-54. 2003..In contrast, inhibition of FAK signaling diminishes MerTK phosphorylation. These results demonstrate that FAK provides an essential link between binding and engulfment mechanisms of integrin-mediated phagocytosis...
- Integrin alpha v beta 3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vesselsP C Brooks
Department of Immunology, Scripps Research Institute, La Jolla, California 92037
Cell 79:1157-64. 1994..We demonstrate therefore that ligation of integrin alpha v beta 3 is required for the survival and maturation of newly forming blood vessels, an event essential for the proliferation of tumors...
- CD36 is required for phagocytosis of apoptotic cells by human macrophages that use either a phosphatidylserine receptor or the vitronectin receptor (alpha v beta 3)V A Fadok
Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
J Immunol 161:6250-7. 1998..A maximum of 70% inhibition was achieved by combining anti-CD36 with either anti-a(v) or PS liposomes...
- NF-kappaB mediates alphavbeta3 integrin-induced endothelial cell survivalM Scatena
Department of Pathology, University of Washington, Seattle, Washington 98195, USA
J Cell Biol 141:1083-93. 1998..In contrast, inhibition of MEK and PI3-kinase did not affect osteopontin-induced NF-kappaB activation. These studies identify NF-kappaB as an important signaling molecule in alphavbeta3 integrin-mediated endothelial cell survival...
- Integrin activation controls metastasis in human breast cancerB Felding-Habermann
Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
Proc Natl Acad Sci U S A 98:1853-8. 2001..Consequently, alterations within tumors that lead to the aberrant control of integrin activation are expected to adversely affect the course of human breast cancer...
- PYK2 in osteoclasts is an adhesion kinase, localized in the sealing zone, activated by ligation of alpha(v)beta3 integrin, and phosphorylated by src kinaseL T Duong
Department of Bone Biology and Osteoporosis, Merck Research Laboratories, West Point, Pennsylvania 19486, USA
J Clin Invest 102:881-92. 1998..Taken together, these findings suggest that Src-dependent tyrosine phosphorylation of PYK2 is involved in the adhesion-induced formation of the sealing zone, required for osteoclastic bone resorption...
- Urokinase receptor interacts with alpha(v)beta5 vitronectin receptor, promoting urokinase-dependent cell migration in breast cancerM V Carriero
National Cancer Institute, Naples, Italy
Cancer Res 59:5307-14. 1999..These data show that uPAR association with alpha(v)beta5 leads to a functional interaction of these receptors and suggest that uPAR directs cytoskeletal rearrangements and cell migration by altering alpha(v)beta5 signaling specificity...
- Peptide ligands for integrin alpha v beta 3 selected from random phage display librariesJ M Healy
Protein Engineering Research Institute, Osaka, Japan
Biochemistry 34:3948-55. 1995....
- Requirement of the NPXY motif in the integrin beta 3 subunit cytoplasmic tail for melanoma cell migration in vitro and in vivoE J Filardo
Department of Immunology, Scripps Research Institute, La Jolla, California 92037, USA
J Cell Biol 130:441-50. 1995..These findings demonstrate that the NPXY motif within the integrin beta 3 cytoplasmic tail is essential for alpha v beta 3-dependent post-ligand binding events involved in cell migration and the metastatic phenotype of melanoma cells...
- Disease-modifying activity of SB 273005, an orally active, nonpeptide alphavbeta3 (vitronectin receptor) antagonist, in rat adjuvant-induced arthritisA M Badger
SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania 19406, USA
Arthritis Rheum 44:128-37. 2001..Measurements of paw inflammation and of bone, cartilage, and soft tissue structure indicated that this compound exerts a protective effect on joint integrity and thus appears to have disease-modifying properties...
- The vitronectin receptor (alpha v beta 3) is implicated, in cooperation with P-selectin and platelet-activating factor, in the adhesion of monocytes to activated endothelial cellsJ F Murphy
INSERM U331 Institut Pasteur de Lyon, , France
Biochem J 304:537-42. 1994..This study shows for the first time that alpha v beta 3 is implicated, in addition to P-selectin and PAF, in the adhesion of monocytes to activated endothelial cells...
- Phosphatidylinositol 3-kinase association with the osteoclast cytoskeleton, and its involvement in osteoclast attachment and spreadingP T Lakkakorpi
Department of Bone Biology and Osteoporosis Research, Merck Research Laboratory, West Point, Pennsylvania 19486, USA
Exp Cell Res 237:296-306. 1997..Finally, PI3-kinase coimmunoprecipitated with alpha v beta 3 integrin from osteoclasts...
- Emergence of alpha 5 beta 1 fibronectin- and alpha v beta 3 vitronectin-receptor expression in melanocytic tumour progressionE H Danen
Department of Pathology, University Hospital Nijmegen, The Netherlands
Histopathology 24:249-56. 1994..Our findings indicate that during melanoma progression alterations in integrin expression occur, the most striking being emergence of alpha 5 beta 1 fibronectin and alpha v beta 3 vitonectin receptor...
- Differential alphav integrin-mediated Ras-ERK signaling during two pathways of angiogenesisJohn D Hood
Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
J Cell Biol 162:933-43. 2003..Thus, integrins alphavbeta3 and alphavbeta5 differentially regulate the Ras-ERK pathway, accounting for distinct vascular responses during two pathways of angiogenesis...
- A monoclonal antibody inhibits adhesion to fibronectin and vitronectin of a colon carcinoma cell line and recognizes the integrins alpha v beta 3, alpha v beta 5, and alpha v beta 6M Lehmann
Institut de Chimie Biologique, ER CNRS 079, , France
Cancer Res 54:2102-7. 1994....
- Blocking monoclonal antibodies to alpha V beta 3 integrin: a unique epitope of alpha V beta 3 integrin is present on human osteoclastsA Chuntharapai
Genentech Inc, South San Francisco, California 94080
Exp Cell Res 205:345-52. 1993..1.3 bound only weakly or not at all to tissues expressing alpha V beta 3 with the exception of osteoclasts. Thus, mAb 10C4.1.3 showed a very narrow tissue specificity being restricted to high-level expression on human osteoclasts...
- An angiogenic laminin site and its antagonist bind through the alpha(v)beta3 and alpha5beta1 integrinsM L Ponce
Craniofacial Developmental Biology and Regeneration Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892, USA
FASEB J 15:1389-97. 2001..Because the laminin gamma1 chain is ubiquitous in most tissues, C16 is likely an important functional site. Since the biological activity of C16 is blocked by a scrambled peptide, C16S may serve as an anti-angiogenic therapeutic agent...
- Molecular cloning of integrin-associated protein: an immunoglobulin family member with multiple membrane-spanning domains implicated in alpha v beta 3-dependent ligand bindingF P Lindberg
Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110
J Cell Biol 123:485-96. 1993..When CHO cells are transfected with human IAP, monoclonal anti-human antibody completely inhibits vitronectin bead binding. These data suggest a model in which ligand binding by alpha v beta 3 is regulated by IAP...
- Vitronectin receptors, alpha v integrins, are recognized by several non-RGD-containing echoviruses in a continuous laboratory cell line and also in primary human Langerhans' islets and endothelial cellsPetri Ylipaasto
National Institute for Health and Welfare, Helsinki, Finland
J Gen Virol 91:155-65. 2010..receptor is also capable of binding the ligands by a non-RGD-dependent mechanism, we investigated whether vitronectin receptors, alpha v integrins, might act as receptors for other echoviruses that do not have the RGD motif...
- Apoptosis of adherent cells by recruitment of caspase-8 to unligated integrinsD G Stupack
Department of Immunology and Department of Vascular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
J Cell Biol 155:459-70. 2001..Integrin ligation disrupts this integrin-caspase containing complex and increases survival, revealing an unexpected role for integrins in the regulation of apoptosis and tissue remodeling...
- Functional overlap and cooperativity among alphav and beta1 integrin subfamilies during skin angiogenesisCarole A Perruzzi
Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
J Invest Dermatol 120:1100-9. 2003....
- A reevaluation of integrins as regulators of angiogenesisRichard O Hynes
Howard Hughes Medical Institute and Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
Nat Med 8:918-21. 2002..This apparent paradox suggests the hypotheses that these integrins are negative regulators of angiogenesis and that the drugs targeting them may be acting as agonists rather than antagonists...
- Enhanced pathological angiogenesis in mice lacking beta3 integrin or beta3 and beta5 integrinsLouise E Reynolds
Cell Adhesion and Disease Laboratory, Richard Dimbleby Department, Imperial Cancer Research Fund, St Thomas Hospital, London, UK
Nat Med 8:27-34. 2002....
- Specific roles of the alpha V beta 1, alpha V beta 3 and alpha V beta 5 integrins in avian neural crest cell adhesion and migration on vitronectinM Delannet
, Institut Jacques Monod, , France
Development 120:2687-702. 1994..cells expressed primarily the alpha V beta 1, alpha V beta 3 and alpha V beta 5 integrins as possible vitronectin receptors. Inhibition assays of cellular adhesion and migration with function-perturbing antibodies demonstrated ..
- Differential roles of CD36 and alphavbeta5 integrin in photoreceptor phagocytosis by the retinal pigment epitheliumS C Finnemann
Margaret M Dyson Vision Research Institute, Department of Ophthalmology and Department of Cell Biology, Weill Medical College of Cornell University, New York, NY 10021, USA
J Exp Med 194:1289-98. 2001..They suggest that CD36 acts as a signaling molecule in postbinding steps of RPE phagocytosis independently of the OS binding receptor alphavbeta5 integrin...
- Activation of alpha(v)beta3-vitronectin binding is a multistage process in which increases in bond strength are dependent on Y747 and Y759 in the cytoplasmic domain of beta3D Boettiger
Department of Microbiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Mol Biol Cell 12:1227-37. 2001..The Y747F mutant blocked the transition from stage 1 to stage 2, and the Y759F blocked the transition from stage 2 to stage 3. The data suggest a model for tension-induced activation of alpha(v)beta3 integrin...
- Multiple roles for platelet GPIIb/IIIa and alphavbeta3 integrins in tumor growth, angiogenesis, and metastasisMohit Trikha
Department of Biology Research, Centocor, Inc, 200 Great Valley Parkway, Malvern, PA 19355, USA
Cancer Res 62:2824-33. 2002..Collectively, these results indicate that combined blockade of GPIIb/IIIa and alphavbeta3 affords significant antiangiogenic and antitumor benefit...
- alpha v-Integrin antagonist EMD 121974 induces apoptosis in brain tumor cells growing on vitronectin and tenascinTakashi Taga
Division of Hematology Oncology, Department of Pediatrics, Childrens Center for Cancer and Blood Diseases, Childrens Hospital Los Angeles, Los Angeles, CA 90027, USA
Int J Cancer 98:690-7. 2002..The dual action of this peptide explains its potent growth suppression of orthotopically transplanted brain tumors...
- Integrin-mediated mechanotransduction requires its dynamic interaction with specific extracellular matrix (ECM) ligandsS Jalali
Department of Bioengineering and The Whitaker Institute of Biomedical Engineering, University of California, San Diego, La Jolla, CA 92093-0427, USA
Proc Natl Acad Sci U S A 98:1042-6. 2001..Our results indicate that the dynamic formation of new connections between integrins and their specific ECM ligands is critical in relaying the signals induced by shear stress to intracellular pathways...
- Macrophage and retinal pigment epithelium phagocytosis: apoptotic cells and photoreceptors compete for alphavbeta3 and alphavbeta5 integrins, and protein kinase C regulates alphavbeta5 binding and cytoskeletal linkageS C Finnemann
Department of Ophthalmology, Margaret M Dyson Vision Institute, New York, New York 10021, USA
J Exp Med 190:861-74. 1999..These data constitute the first evidence that noninflammatory phagocytes actively regulate the earliest phase of phagocytic clearance, particle binding, by controlling receptor activity...
- A mechanism for modulation of cellular responses to VEGF: activation of the integrinsT V Byzova
Joseph J Jacobs Center for Thrombosis and Vascular Biology, Department of Molecular Cardiology, Cleveland Clinic Foundation, Ohio 44195, USA
Mol Cell 6:851-60. 2000..Thus, integrin activation provides a mechanism for VEGF to induce a broad spectrum of cellular responses...
- Rac recruits high-affinity integrin alphavbeta3 to lamellipodia in endothelial cell migrationW B Kiosses
Department of Vascular Biology, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
Nat Cell Biol 3:316-20. 2001..By using WOW-1, we have identified the selective recruitment of high-affinity integrins as a mechanism by which lamellipodia promote formation of new adhesions at the leading edge in cell migration...
- Targeted antiangiogenic therapy for cancer using Vitaxin: a humanized monoclonal antibody to the integrin alphavbeta3J C Gutheil
Department of Clinical Oncology Research, Sidney Kimmel Cancer Center, San Diego, California 92121, USA
Clin Cancer Res 6:3056-61. 2000..At the doses and schedule studied, Vitaxin appears safe and potentially active, suggesting that vascular integrin alphavbeta3 represents a clinically relevant antiangiogenic target for prolonged cancer therapy...
- Plasmin-sensitive dibasic sequences in the third fibronectin-like domain of L1-cell adhesion molecule (CAM) facilitate homomultimerization and concomitant integrin recruitmentS Silletti
Department of Pediatrics, University of California at San Diego, La Jolla, California 92037, USA
J Cell Biol 149:1485-502. 2000....
- Tumstatin, an endothelial cell-specific inhibitor of protein synthesisYohei Maeshima
Program in Matrix Biology, Department of Medicine and the Cancer Center, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
Science 295:140-3. 2002..These results establish a role for integrins in mediating cell-specific inhibition of cap-dependent protein synthesis and suggest a potential mechanism for tumstatin's selective effects on endothelial cells...
- Normal development, wound healing, and adenovirus susceptibility in beta5-deficient miceX Huang
Lung Biology Center, University of California, San Francisco, San Francisco, California 94143 0854, USA
Mol Cell Biol 20:755-9. 2000..These data suggest that alphavbeta5 is not essential for normal development, reproduction, adenovirus infection, or the healing of cutaneous wounds...
- Integrin alpha(v)beta1 is an adenovirus coreceptorE Li
Department of Immunology, The Scripps Research Institute, La Jolla, California 92037, USA
J Virol 75:5405-9. 2001....
- Canstatin acts on endothelial and tumor cells via mitochondrial damage initiated through interaction with alphavbeta3 and alphavbeta5 integrinsClaire Magnon
UMR 8121 Laboratoire de vectorologie et transfert de gènes, Institut Gustave Roussy, Villejuif Cedex, France
Cancer Res 65:4353-61. 2005..Taken together, these results provide insights into how canstatin might exert its strong anticancer effect...
- Superactivation of integrin alphavbeta3 by low antagonist concentrationsD F Legler
Institute of Biochemistry, University of Lausanne, CH-1066 Epalinges, Switzerland
J Cell Sci 114:1545-53. 2001..Our results indicate that low concentrations of the ligand mimetic cyclo-RGD can result in superactivation of the extracellular domain of integrin alphavbeta3 to a comparable level as activation by manganese...
- Role of alphavbeta3 integrin in the activation of vascular endothelial growth factor receptor-2R Soldi
Institute for Cancer Research and Treatment IRCC, Biology and Biochemistry, School of Medicine, University of Torino, 10100 Torino, Italy
EMBO J 18:882-92. 1999....
- Focally regulated endothelial proliferation and cell death in human synoviumD A Walsh
Inflammation Group, Queen Mary and Westfield College, London, United Kingdom
Am J Pathol 152:691-702. 1998..Increased endothelial cell turnover may contribute to microvascular dysfunction and thereby facilitate persistent synovitis...
- Spatial organization of microfilaments and vitronectin receptor, alpha v beta 3, in osteoclasts. A study using confocal laser scanning microscopyP T Lakkakorpi
Department of Anatomy, University of Oulu, Finland
J Cell Sci 104:663-70. 1993..abstract truncated at 250 words)..
- Involvement of tumor cell integrin alpha v beta 3 in hematogenous metastasis of human melanoma cellsBrunhilde Felding-Habermann
Department of Molecular and Experimental Medicine, Scripps Research Institute, Mail MEM 175, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
Clin Exp Metastasis 19:427-36. 2002....
- Proinflammatory cytokines potentiate thrombospondin-mediated phagocytosis of neutrophils undergoing apoptosisY Ren
Department of Medicine, University Hospital, Nottingham, UK
J Immunol 154:2366-74. 1995..Thus, M phi phagocytosis of apoptotic neutrophils can be potentiated by proinflammatory cytokines, suggesting a mechanism for negative feedback control of neutrophil number at inflamed sites...
- Molecular pathway for cancer metastasis to boneSarmishtha De
Departments of Molecular Cardiology and Cardiology, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
J Biol Chem 278:39044-50. 2003..Supporting this model, activated integrins were found to colocalize with VEGFR-2 in tissue samples of metastatic prostate tumors from patients...
- Purification and functional characterization of integrin alpha v beta 5. An adhesion receptor for vitronectinJ W Smith
Department of Immunology IMM13, Research Institute of Scripps Clinic, La Jolla, California 92037
J Biol Chem 265:11008-13. 1990..Secondly, polyclonal antibodies raised against alpha v beta 5 immunoprecipitate both beta 5 and beta x, and finally, the amino-terminal amino acid sequences of beta x and beta 5 are identical...
- Insulin-like growth factor receptor cooperates with integrin alpha v beta 5 to promote tumor cell dissemination in vivoP C Brooks
Department of Immunology, Scripps Research Institute, La Jolla, California 92037, USA
J Clin Invest 99:1390-8. 1997..These findings provide evidence that integrin ligation, in conjunction with cytokine activation, plays an important role in the dissemination of malignant tumor cells...
- Integrin alpha v beta 3 rescues melanoma cells from apoptosis in three-dimensional dermal collagenA M Montgomery
Department of Immunology, Scripps Research Institute, La Jolla, CA 92037
Proc Natl Acad Sci U S A 91:8856-60. 1994..These findings provide evidence that the survival and growth of transformed cells may be regulated by collagen degradation and integrin-dependent anchorage to this proteolysed matrix...
- The cell adhesion domain in plasma vitronectin is crypticD Seiffert
Department of Vascular Biology, The Scripps Research Institute, La Jolla, California 92037, USA
J Biol Chem 272:13705-10. 1997..The data presented here indicate that such conformational changes in Vn are likely to occur in areas of tissue injury and thrombosis...
- Alpha v integrins as receptors for tumor targeting by circulating ligandsR Pasqualini
La Jolla Cancer Research Center, Burnham Institute, La Jolla, CA, USA RP ER
Nat Biotechnol 15:542-6. 1997....
- The alphavbeta3 integrin regulates alpha5beta1-mediated cell migration toward fibronectinK O Simon
Department of Bone Biology and Osteoporosis, Merck Research Laboratories, West Point, Pennsylvania 19486, USA
J Biol Chem 272:29380-9. 1997..These findings demonstrate alphavbeta3 regulation of alpha5beta1-mediated cell migration and suggest that the beta3 transmembrane domain is essential for this function...
- The thrombospondin receptor integrin-associated protein (CD47) functionally couples to heterotrimeric GiW A Frazier
Departments of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Biol Chem 274:8554-60. 1999..This functional coupling of CD47 to heterotrimeric G proteins provides a mechanistic explanation for the biological effects of CD47 in a wide variety of systems...
- Tumor regression by targeted gene delivery to the neovasculatureJohn D Hood
Department of Immunology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
Science 296:2404-7. 2002..Systemic injection of the NP into mice resulted in apoptosis of the tumor-associated endothelium, ultimately leading to tumor cell apoptosis and sustained regression of established primary and metastatic tumors...
- The osteoclast functional antigen, implicated in the regulation of bone resorption, is biochemically related to the vitronectin receptorJ Davies
Imperial Cancer Research Fund, St Bartholomew s Hospital, London, UK
J Cell Biol 109:1817-26. 1989..These, and other, data provide the first indication of a function for the VNR and suggest that cell-cell and cell-extracellular matrix interactions involving integrins may play an important role in bone physiology...
- Syndecan-1 regulates alphavbeta5 integrin activity in B82L fibroblastsKyle J McQuade
Graduate Programs in Cellular and Molecular Biology, University of Wisconsin Madison, Madison, WI 53706, USA
J Cell Sci 119:2445-56. 2006..These results suggest that the ectodomain of the syndecan-1 core protein contains an active site that assembles into a complex with the alphavbeta5 integrin and regulates alphavbeta5 integrin activity...
- Different populations of macrophages use either the vitronectin receptor or the phosphatidylserine receptor to recognize and remove apoptotic cellsV A Fadok
National Jewish Center for Immunology and Respiratory Medicine, Denver, CO 80206
J Immunol 149:4029-35. 1992..These results suggest that the mechanism by which apoptotic cells are recognized and phagocytosed by macrophages is determined by the subpopulation of macrophages studied...
- The adhesive and migratory effects of osteopontin are mediated via distinct cell surface integrins. Role of alpha v beta 3 in smooth muscle cell migration to osteopontin in vitroL Liaw
Department of Pathology, University of Washington, Seattle 98195
J Clin Invest 95:713-24. 1995..Thus, interaction with distinct receptors is one mechanism by which osteopontin may initiate multiple functions...
- Inhibition of FGF-2-mediated chemotaxis of murine brain capillary endothelial cells by cyclic RGDfV peptide through blocking the redistribution of c-Src into focal adhesionsT Shono
Department of Urology, Nagasaki University School of Medicine, Sakamoto, Nagasaki, Japan
Exp Cell Res 268:169-78. 2001..Our results indicated that cRGDfV peptide inhibited redistribution of c-Src into focal adhesions, leading to impaired MAPK activation within focal adhesions and motility in FGF-2-treated endothelial cells...
- Stimulation of migration of human aortic smooth muscle cells by vitronectin: implications for atherosclerosisS L Brown
Cardiovascular Division, Washington University School of Medicine, St Louis, MO 63110
Cardiovasc Res 28:1815-20. 1994....
- 99mTc-NC100692--a tracer for imaging vitronectin receptors associated with angiogenesis: a preclinical investigationDavid Edwards
Research and Development, GE Healthcare, Medical Diagnostics, The Grove Centre, HP7 9LL Amersham, UK
Nucl Med Biol 35:365-75. 2008....
- The muscle-specific laminin receptor alpha7 beta1 integrin negatively regulates alpha5 beta1 fibronectin receptor functionD Tomatis
Dipartimento di Genetica, Biologia e Biochimica, Universita di Torino, Turin, 10126, Italy
Exp Cell Res 246:421-32. 1999..In conclusion, the data reported establish the existence of a negative cooperativity between alpha7 and alpha5 integrins that may be important in determining functional regulation of integrins during myogenic differentiation...
- The selective regulation of alpha Vbeta 1 integrin expression is based on the hierarchical formation of alpha V-containing heterodimersPekka Koistinen
MediCity Research Laboratory and the Department of Medical Biochemistry, Turku Graduate School of Biomedical Sciences, University of Turku, FIN 20520 Turku, Finland
J Biol Chem 277:24835-41. 2002..These observations explain how alphaVbeta1 can be specifically regulated without concomitant changes in the expression of other alphaV or beta1 integrins...
- Vitronectin receptors are expressed by macaque trophoblast cells and play a role in migration and adhesion to endotheliumG C Douglas
Department of Cell Biology and Human Anatomy, School of Medicine, University of California, Davis, CA 95616 8643, USA
Biochim Biophys Acta 1452:36-45. 1999..We sought to determine whether trophoblast cells isolated from early gestation macaque placentas expressed vitronectin receptors and tested the idea that these receptors play a role in trophoblast migration and adhesion...
- Localisation of vitronectin receptor immunoreactivity and tartrate resistant acid phosphatase activity in synovium from patients with inflammatory or degenerative arthritisB A Ashton
Department of Rheumatology, Robert Jones and Agnes Hunt Orthopaedic Hospital, Oswestry, United Kingdom
Ann Rheum Dis 52:133-7. 1993..The results show that fully differentiated osteoclasts are uncommon in synovium from patients with either degenerative or inflammatory arthropathies...
- A mechanism for divalent cation regulation of beta 3-integrinsJ W Smith
Committee on Vascular Biology CVB 1, Scripps Research Institute, La Jolla, California 92037
J Biol Chem 269:960-7. 1994..Consequently, the data presented here suggest a mechanism in which two separate cation-binding sites regulate ligand binding to beta 3-integrins...
- Requirement of integrin beta3 tyrosine 747 for beta3 tyrosine phosphorylation and regulation of alphavbeta3 avidityS D Blystone
Department of Medicine, Infectious Diseases Division, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Biol Chem 272:28757-61. 1997..Because the motif in beta3 required for tyrosine phosphorylation is shared by several integrin beta-chains, this may be a conserved mechanism for regulation of integrin-dependent adhesion...
- Regulation of integrin-mediated adhesion at focal contacts by cyclic AMPW F Glass
Department of Pathology, University of Texas Health Science Center at San Antonio
J Cell Physiol 157:296-306. 1993..Although other types of extracellular matrix receptors may also be involved, our observations suggest that cAMP regulates adhesion at focal contacts but not at fibronexus-type extracellular matrix contacts...
- RGD-mutants of B-lymphotropic polyomavirus capsids specifically bind to alpha(v)beta3 integrinJ Langner
Research Program Infection and Cancer, Deutsches Krebsforschungszentrum, Heidelberg, Germany
Arch Virol 149:1877-96. 2004..This selective binding of the mutant capsids could be inhibited by synthetic peptides that specifically bind to alpha(v)beta3 integrin with IC50 values between 10 and 40 nM...
- CAR is a cell-cell adhesion protein in human cancer cells and is expressionally modulated by dexamethasone, TNFalpha, and TGFbetaA Bruning
Department of Obstetrics and Gynecology, Molecular Biology Laboratory, University of Freiburg, Hugstetter Strasse 55, D 79106 Freiburg, Germany
Gene Ther 10:198-205. 2003..In clinical cancer gene therapy, efficiency of adenoviral gene delivery could be altered by cell adhesion, TNFalpha, TGFbeta, and dexamethasone...
- Chemical adaptor immunotherapy: design, synthesis, and evaluation of novel integrin-targeting devicesLian Sheng Li
The Skaggs Institute for Chemical Biology and Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
J Med Chem 47:5630-40. 2004....
- Expression of the coxsackie and adenovirus receptor in human astrocytic tumors and xenograftsJonas Fuxe
Ludwig Institute for Cancer Research, Stockholm Branch, Stockholm, Sweden
Int J Cancer 103:723-9. 2003..01). Two xenografts with low hCAR expression grew considerably faster than the hCAR-expressing cells. Our results have relevance for the use of adenoviruses in gene therapy against astrocytomas...
- On the mode of action of thrombin-induced angiogenesis: thrombin peptide, TP508, mediates effects in endothelial cells via alphavbeta3 integrinNikos E Tsopanoglou
Department of Pharmacology, Medical School, University of Patras, Rio Patras, Greece
Thromb Haemost 92:846-57. 2004..These results point to the importance of RGD sequence of thrombin in mediating effects on endothelial cells and angiogenesis...
- The pattern of enhancement of Src kinase activity on platelet-derived growth factor stimulation of glioblastoma cells is affected by the integrin engagedQiang Ding
Department of Pathology, Division of Neuropathology, The University of Alabama at Birmingham, 35294, USA
J Biol Chem 278:39882-91. 2003..Notably, the data indicate that engagement of different integrins alters the identity of the Src family members that are activated on stimulation with PDGF...
- Design, synthesis, and evaluation of radiolabeled integrin alpha v beta 3 receptor antagonists for tumor imaging and radiotherapyThomas D Harris
Discovery Research, Bristol Myers Squibb Medical Imaging, North Billerica, MA 01862, USA
Cancer Biother Radiopharm 18:627-41. 2003..Tumors are visible as early as 0.5 hours PI. Radiotherapy studies in the c-neu Oncomouse model demonstrated a slowing of tumor growth at a dose of 15 mCi/m(2), and a regression of tumors at a dose of 90 mCi/m(2)...
- Rac2 specificity in macrophage integrin signaling: potential role for Syk kinaseDe Pradip
Section of Hematology Oncology, Department of Pediatrics, Biochemistry and Molecular Biology, Herman B Wells Center for Pediatric Research, School of Medicine of Indiana University, 1044 W Walnut Street, Indianapolis, IN 46202, USA
J Biol Chem 278:41661-9. 2003....
- Alphav-integrin utilization in human beta-cell adhesion, spreading, and motilityThomas Kaido
Islet Research Laboratory at The Whittier Institute for Diabetes, Department of Pediatrics, The University of California at San Diego, La Jolla, California 92037, USA
J Biol Chem 279:17731-7. 2004..By supporting fetal beta-cell migration, alpha(v)beta(1) could play an important role in early motile processes required for islet neogenesis...
- The endoproteolytic processing of alphavbeta5 integrin is involved in cytoskeleton remodelling and cell migrationVirginie Berthet
CNRS UMR6032, Faculte de Pharmacie, 27 Bd J Moulin, 13385 Marseille Cedex 5, France
FEBS Lett 557:159-63. 2004..The alphav subunit cleavage is thus essential for integrin function and has a considerable impact on integrin-dependent events, especially those leading to cell migration...
- Alpha(v)beta3 and alpha(v)beta5 integrins bind both the proximal RGD site and non-RGD motifs within noncollagenous (NC1) domain of the alpha3 chain of type IV collagen: implication for the mechanism of endothelia cell adhesionVadim Pedchenko
Division of Nephrology, Veterans Affairs Hospital, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
J Biol Chem 279:2772-80. 2004..Therefore, the RGD site, in addition to non-RGD motifs, may contribute to the mechanisms of endothelial cell adhesion in the human vasculature and the anti-angiogenic activity of the RGD-alpha3NC1 domain...
- alphav beta 3 and alphav beta 5 integrin antagonists inhibit angiogenesis in vitroRiccardo E Nisato
Department of Morphology, University Medical Center, Geneva, Switzerland
Angiogenesis 6:105-19. 2003....
- Conditionally replicative adenovirus with tropism expanded towards integrins inhibits osteosarcoma tumor growth in vitro and in vivoAdhiambo M Witlox
Department of Orthopedic Surgery, VU University Medical Center, Amsterdam, The Netherlands
Clin Cancer Res 10:61-7. 2004..The oncolytic capacity of the CRAd Ad5-Delta24RGD was tested on primary OS cells in vitro and in vivo...
- Transglutaminase-mediated oligomerization of the fibrin(ogen) alphaC domains promotes integrin-dependent cell adhesion and signalingAlexey M Belkin
University of Maryland School of Medicine, 15601 Crabbs Branch Way, Rockville, MD 20855, USA
Blood 105:3561-8. 2005..They also suggest a new role for transglutaminases in regulation of integrin-mediated adhesion and signaling via covalent modification of integrin ligands...
- Alphavbeta integrins play an essential role in BMP-2 induction of osteoblast differentiationChung Fang Lai
Division of Bone and Mineral Diseases, Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
J Bone Miner Res 20:330-40. 2005..BMP-2 stimulates alphavbeta expression. BMP-2 receptors co-localize/overlap with alphavbeta integrins, and the intact function of alphavbeta is essential in BMP-2 activity...
- Blockade of alpha v beta3 and alpha v beta5 integrins by RGD mimetics induces anoikis and not integrin-mediated death in human endothelial cellsSylvie Maubant
Centre National de Recherche Scientifique, Unité Mixte de Recherche CNRS UMR 6543, Centre Antoine Lacassagne, Nice, France
Blood 108:3035-44. 2006..Altogether, these findings have important implications for the development of this class of antiangiogenics...
- Cell surface overexpression of alphavbeta5 integrin impedes alphavbeta3-mediated migration of the human ovarian adenocarcinoma cell line IGROV1Sylvie Maubant
GRECAN, Université de Caen Basse Normandie and Centre de Lutte Contre le Cancer François Baclesse, Avenue du General Harris, 14076 Caen Cedex 05, France
Cell Biol Int 31:109-18. 2007..Finally, the response to cisplatin was not significantly modified in beta5 transfectants when compared to IGROV1 parental cells...
- Synthesis and biological evaluation of new conformationally biased integrin ligands based on a tetrahydroazoninone scaffoldLuca Banfi
Department of Chemistry and Industrial Chemistry, Via Dodecaneso 31, 16146 Genova, Italy
Bioorg Med Chem Lett 17:1341-5. 2007..They exhibit interesting activity towards integrin alphaVbeta3 and a remarkable selectivity in comparison with integrin alphaVbeta5...
- The lipoxygenase inhibitor, baicalein, modulates cell adhesion and migration by up-regulation of integrins and vinculin in rat heart endothelial cellsY C S Hsieh
Graduate Institute of Chinese Pharmaceutical Sciences, China Medical University, Taichung, Taiwan, ROC
Br J Pharmacol 151:1235-45. 2007..We reported previously that baicalein strongly inhibited proliferation of rat heart endothelial cells and here we assess effects on migration and adhesion of these cells...
- Integrin alphavbeta6 mediates HT29-D4 cell adhesion to MMP-processed fibrinogen in the presence of Mn2+Francis Fouchier
Laboratoire de Génie Génétique et Biotechnologie, INSERM 476, INRA 1260, Faculte de Pharmacie, 27 Bd Jean Moulin, F 13385 Marseille Cedex 5, France
Eur J Cell Biol 86:143-60. 2007..Finally, we found that Mn(2+) and activators of the ERK pathway cooperated in HT29-D4 cell adhesion to Fb. Such a process may be involved in bone metastasis of some cancer cells...
- Distinctive role of integrin-mediated adhesion in TNF-induced PKB/Akt and NF-kappaB activation and endothelial cell survivalG Bieler
Division of Experimental Oncology, Lausanne Cancer Centre, Epalinges, Switzerland
Oncogene 26:5722-32. 2007..The sensitizing effect of EMD121974 on TNF cytotoxicity may open new perspectives to the therapeutic use of TNF as anticancer agent...
- PROTECTIVE ROLE OF APOPTOSIS IN ASBESTOS PLEURAL INJURYV Broaddus; Fiscal Year: 2001..Then, she will determine the mechanisms by which certain signals, namely those initiated by vitronectin receptors, inhibit asbestos-induced apoptosis...
- SECRETED PHOSPHOPROTEINS ASSOCIATED WITH TUMORIGENICITYDONALD SENGER; Fiscal Year: 1993..Sppl mediate their different effects via the same or different receptors and if they bind to vitronectin receptors. Finally, detailed immunohistochemical studies on the distribution of Sppl in human benign and malignant ..
- DISTRIBUTION AND FUNCTION OF THE INTEGRIN ANDYB8Stephen Nishimura; Fiscal Year: 1999..How does the unique structure of beta8 relate to its function? Why does the melanoma cell express multiple vitronectin receptors and how does their expression correlate to the invasive phenotype? To answer these questions I will ..
- Alpha v beta 5 integrin in retinal pigment epitheliumSILVIA FINNEMANN; Fiscal Year: 2004..The mechanisms of these interactions and the unique localization of v5 integrin in RPE are conserved among species. Exploring the 5 null mouse is thus important to understand human disease. ..
- The Integrin Ligand MFG-E8 and Photoreceptor Outer Segment Renewal.SILVIA FINNEMANN; Fiscal Year: 2007....
- Integrin Activation in Breast Cancer MetastasisBrunhilde Felding Habermann; Fiscal Year: 2006....
- MODULATION OF ALPHA 5 BETA 1 INTEGRINDavid Boettiger; Fiscal Year: 2007..abstract_text> ..
- Targeting Metastatic Breast Cancer with Human AntibodiesBrunhilde Felding Habermann; Fiscal Year: 2009..Novel immunoconjugates containing small, highly toxic compounds will be tested for their effects on metastatic breast cancer. If successful, this work will contribute to an improvement of current anti-cancer treatment. ..
- IVIS 200 Imaging SystemBrunhilde Felding Habermann; Fiscal Year: 2005..abstract_text> ..
- Nanoparticle targeting of cathepsin-L inhibitor and doxorubicin in breast cancerShaker Mousa; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- GENETIC ANALYSIS OF RNA TUMOR VIRUSESDavid Boettiger; Fiscal Year: 2003..This will be applied to analysis of the role of src in regulation of cytoskeletal structure and the linkage of cytoskeleton to integrin. ..
- Integrins and bone matrix in prostate cancerTatiana Byzova; Fiscal Year: 2006..abstract_text> ..
- 2006 Gordon Research Conference on Signal Transduction By Engineered ECMMichael Sheetz; Fiscal Year: 2006..A special effort will be made to use the financial support requested to facilitate the attendance and participation of women and minorities in this meeting. [unreadable] [unreadable] [unreadable]..
- Genetic.Engin.Cells/Scaffolds for Bone Tissue Engineeri.Andres Garcia; Fiscal Year: 2006..abstract_text> ..
- Cell type gene delivery and alcoholic liver diseaseMichael Wheeler; Fiscal Year: 2006..In addition, through didactic training, and interactions with his mentor and key faculty, the applicant will acquire new skills that will allow him to become a successful member of the alcohol research community. ..
- Ceramide in angiogenic integrin signalingAnat Erdreich Epstein; Fiscal Year: 2006....
- CD47/IAP Modulation of Immune Cell FunctionsWilliam Frazier; Fiscal Year: 2006..3. Use CD47 null mice to define the role of CD47 in development of immune cells, in class switching during an immune response and in autoimmunity. ..
- A MULTI-USE GLIOMA BIOREPOSITORYTom Mikkelsen; Fiscal Year: 2006..We seek support to expand this multi-use glioma biorepository into an ongoing resource of the best characterized glioma material with clinical correlative and genomic data available. ..
- Does FAK mediate implant microtopographyGalen Schneider; Fiscal Year: 2006..This would allow for a controlled, localized, site specific tissue engineering approach in association with Dental implant therapy. ..
- SYNOVIAL DYSFUNCTION DUE TO P53 ABNORMALITIES IN RAGary Firestein; Fiscal Year: 2006..abstract_text> ..
- Biophysical Properties of Membranes: Lipid-Protein BondsMichael Sheetz; Fiscal Year: 2006..abstract_text> ..
- Nanostructure Devices for Measuring Cell MechanicsMichael Sheetz; Fiscal Year: 2009..These studies have many practical applications in tissue engineering and in designing potential therapies for wound healing, cancer and a variety of disorders. ..
- HIV-1 gp120-mediated injury in brain endotheliumShalom Avraham; Fiscal Year: 2009..These studies should provide insights into preventive and/or therapeutic strategies to sustain BBB integrity in HIV-infected patients, and thereby contribute to limiting CNS pathology. ..
- STRUCTURE AND ASSEMBLY OF CYTOSKELETAL FILAMENTSMichael Sheetz; Fiscal Year: 2009....
- FLOW EFFECTS ON ENDOTHELIAL/TROPHOBLAST INTERACTIONGORDON DOUGLAS; Fiscal Year: 2008..FSSinduced trophoblast migration will be quantified in cells in which MUC1 internalization has been blocked. ..
- FGF RECEPTOR SIGNALING IN BONE DEVELOPMENTJoseph Schlessinger; Fiscal Year: 2009....
- Glucocorticoids and Programming of the Hypertensive Vascular PhenotypeOmid Khorram; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- Resolution of Gouty InflammationSTEPHEN MALAWISTA; Fiscal Year: 2008..We suggest further that this reprogramming of lipid mediators may explain in part the action of therapeutic agents such as colchicine, and could lead to better treatment for this condition. [unreadable] [unreadable] [unreadable]..
- Brain tumor angiogenesis: Integrin ceramide signalingAnat Erdreich Epstein; Fiscal Year: 2008..abstract_text> ..
- Integrin-specific implant surfaces for bone repairAndres Garcia; Fiscal Year: 2008..Collectively, these studies will validate this biomolecular surface engineering approach for developing biologically active implants for enhanced bone repair. ..
- NEW APPLICATIONS IN BRAIN TUMOR THERAPYTom Mikkelsen; Fiscal Year: 2008..These efforts speak to the ultimate goal of our group and NABTT Consortium: improving the outcome of brain tumor patients. ..
- Gas6/Mertk mediated phagocytosis of OS by RPE cellsMichael Hall; Fiscal Year: 2005..abstract_text> ..
- TAP20, NOVEL INTEGRIN MODULATING PROTEINShaoqing Tang; Fiscal Year: 2001..We anticipate that these studies should provide data that will be useful in designing new strategic for pharmacologic intervention in ischemic vascular disease and cancer. ..
- PHOSPHATIDYLSERINE-SPECIFIC RECEPTOR FOR APOPTOTIC CELLSValerie Fadok; Fiscal Year: 2004..The investigators hypothesize that PS recognition has been preserved throughout phylogeny as an effective mechanism mediating the removal of apoantibodies. ..
- LEUKOCYTE INTEGRIN ALPHA M BETA 2Edward Plow; Fiscal Year: 2004....
- THE STRUCTURE AND FUNCTION OF PLATELET GPIIB-IIIAEdward Plow; Fiscal Year: 2003..At the same time, these studies may have direct bearing on the use and future development of the GPIIb-IIIa blockers as antithrombotic agents. ..
- LYME DISEASE--HOST PARASITE INTERACTIONSSTEPHEN MALAWISTA; Fiscal Year: 2003..These studies may provide the technical and conceptual basis for improvements in diagnostic and prognostic aspects of inflammatory diseases. ..
- INTEGRIN ANTAGONISTS IN GLIOMA BIOLOGY, IMAGING, THERAPYTom Mikkelsen; Fiscal Year: 2003..abstract_text> ..
- MOLECULAR BASIS OF ORGANELLE MOVEMENT IN AXONSMichael Sheetz; Fiscal Year: 2002....
- ROLE OF THE NUCLEAR MATRIX PROTEIN NRB/B IN BRAINShalom Avraham; Fiscal Year: 2002..These studies should provide novel insights into the role of this nuclear matrix protein in neuronal differentiation. ..
- INTERACTION OF OSTEOPONTIN WITH ADHESION RECEPTORSJOEL BENNETT; Fiscal Year: 2002..Our results suggest that it may be possible to inhibit the formation of platelet thrombi in arteries involved by atherosclerosis by preventing the interaction of platelet alphavbeta3 with osteopontin. ..
- REGULATION OF PERIPHERAL INFLAMMATION BY THE CNSGary Firestein; Fiscal Year: 2002..These studies will provide a basis for understanding the central nervous system-immune system connection as well as explore novel therapeutic targets. ..
- REGULATION OF ANGIOGENESIS BY THROMBOSPONDINWilliam Frazier; Fiscal Year: 2004..The TSP/CD36 system provides a normally functioning entre into the control of angiogenesis in which the ligand and receptor are well defined and whose mechanism will be elucidated as indicated above. ..
- MACAQUE IN VITRO IMPLANTATION MODELGORDON DOUGLAS; Fiscal Year: 2004..Specific Aim 3 will use neutralizing antibodies and immobilized recombinant chemokines to characterize the role of chemokines in regulating expression of trophoblast migratory phenotypic markers and blastocyst development. ..
- IKKi expression and regulation in rheumatoid arthritisGary Firestein; Fiscal Year: 2005..We propose to test the hypothesis that IKKi is an important signal transduction pathway that regulates inflammation in chronic arthritis and is a novel target for development of anti-rheumatic agents. ..
- CELL SURFACE STRUCTURE AND TRANSFORMATIONSRichard Hynes; Fiscal Year: 2005..Evaluation of the functions of cell adhesion proteins and the consequences of their misexpression in metastatic cells will lead to new leads for therapeutic interventions against metastasis. ..
- 2004 Hemostasis Gordon Research ConferenceEdward Plow; Fiscal Year: 2004..The Hemostasis Gordon Conference has been a highly successful and enjoyable meeting, frequently identified as the best meeting attended by participants; and we believe that the current program has the potential to extend this tradition. ..
- ENDOTHELIAL SIGNALING MECHANISMS IN LUNG INJURYSunita Bhattacharya; Fiscal Year: 2005..These mechanisms are highly relevant to the general understanding of the lung inflammatory response. No previous understanding of these mechanisms exists for lung endothelium in vivo. The proposed studies will be novel. ..
- MOLECULAR GLIOMA THERAPIES AND DIAGNOSTICSTom Mikkelsen; Fiscal Year: 2004..abstract_text> ..
- Thrombospondins and AtherothrombosisEdward Plow; Fiscal Year: 2004..Together, these studies should provide a rigorous test of the hypothesis and extend our knowledge of the roles of the TSPs in cardiovascular biology. ..
- Molecular Mechanisms That Regulate CD11d ExpressionJOHN NOTI; Fiscal Year: 2004..Transgenic analysis of the CD11d cis elements will be done to complement these studies. These studies will expand our understanding of normal myeloid development and leukemogenesis. ..
- Single Fiber Forces from Cardiac FibroblastsMichael Sheetz; Fiscal Year: 2004..abstract_text> ..
- Anthrax Vaccine Formulations Combining PA/Spore EpitopesAAIYAPPA PALECANDA; Fiscal Year: 2005..Significance: This research is relevant to the potential to develop novel vaccine formulations and therapeutics to counter inhalation anthrax. ..
- Docking protein FRS2 in FGF signalingJoseph Schlessinger; Fiscal Year: 2008..abstract_text> ..
- Integrins and Orthodontic Tooth MovementCalogero Dolce; Fiscal Year: 2002..Aim 2 experiments will assess the rate and extent of alveolar bone turnover using histomorphometric means. These data may demonstrate the usefulness of the RGD peptide in modulating both bone formation and resorption during OTM. ..
- AUTOIMMUNE THROMBOCYTOPENIARobert McMillan; Fiscal Year: 2002..Results of these studies will be correlated with the patients' clinical course and thrombopoietin levels. In addition, the effect of immune thrombocytopenia on the patients' quality of life will be studied. ..
- Human Endometrial Nitric Oxide: Regulation and FunctionOmid Khorram; Fiscal Year: 2003..This pilot study should shed light on regulation and function of human endometrial NO pathway, an uninvestigated area of research with profound clinical significance. ..
- Mineralization: Integrins and Focal Adhesion KinaseGalen Schneider; Fiscal Year: 2003..This will allow for development of new therapeutic approaches that in turn could lead to novel treatments and tissue-engineered biological applications to increase the quality of life for many patients. ..
- Fragments of TrpRS to Treat Neovascular Eye DiseasesMartin Friedlander; Fiscal Year: 2006..abstract_text> ..
- CORE GRANT FOR VISION RESEARCHMartin Friedlander; Fiscal Year: 2005..abstract_text> ..