vitronectin receptors

Summary

Summary: Receptors such as INTEGRIN ALPHAVBETA3 that bind VITRONECTIN with high affinity and play a role in cell migration. They also bind FIBRINOGEN; VON WILLEBRAND FACTOR; osteopontin; and THROMBOSPONDINS.

Top Publications

  1. ncbi Vitronectin and its receptors
    B Felding Habermann
    Department of Molecular and Experimental Medicine, Scripps Research Institute, La Jolla, California 92037
    Curr Opin Cell Biol 5:864-8. 1993
  2. ncbi Solution structures and integrin binding activities of an RGD peptide with two isomers
    N Assa-Munt
    Cancer Research Center, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA
    Biochemistry 40:2373-8. 2001
  3. ncbi Adhesion and migration of extracellular matrix-stimulated breast cancer
    John E Bartsch
    Department of Surgery, Medical College of Ohio, 3065 Arlington Avenue, Ohio 43614 5807, Toledo, USA
    J Surg Res 110:287-94. 2003
  4. ncbi Biological and molecular properties of a new alpha(v)beta3/alpha(v)beta5 integrin antagonist
    Laura Belvisi
    Organic and Industrial Chemistry Department, Centre for Biomolecular Interdisciplinary Studies and Industrial Applications, University of Milan, Italy
    Mol Cancer Ther 4:1670-80. 2005
  5. ncbi Requirement of vascular integrin alpha v beta 3 for angiogenesis
    P C Brooks
    Department of Immunology, Scripps Research Institute, La Jolla, CA 92037
    Science 264:569-71. 1994
  6. ncbi Endothelial cell attachment and spreading on human tenascin is mediated by alpha 2 beta 1 and alpha v beta 3 integrins
    P Sriramarao
    La Jolla Institute for Experimental Medicine, CA 92037
    J Cell Sci 105:1001-12. 1993
  7. ncbi A signaling pathway from the alpha5beta1 and alpha(v)beta3 integrins that elevates bcl-2 transcription
    M L Matter
    Cancer Research Center, The Burnham Institute, La Jolla, California 92037, USA
    J Biol Chem 276:27757-63. 2001
  8. pmc Src-mediated coupling of focal adhesion kinase to integrin alpha(v)beta5 in vascular endothelial growth factor signaling
    Brian P Eliceiri
    Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Cell Biol 157:149-60. 2002
  9. pmc Thrombospondin cooperates with CD36 and the vitronectin receptor in macrophage recognition of neutrophils undergoing apoptosis
    J Savill
    Department of Medicine, Royal Postgraduate Medical School, Hammersmith Hospital, London, United Kingdom
    J Clin Invest 90:1513-22. 1992
  10. pmc Integrin alpha v beta 3 differentially regulates adhesive and phagocytic functions of the fibronectin receptor alpha 5 beta 1
    S D Blystone
    Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110
    J Cell Biol 127:1129-37. 1994

Research Grants

  1. PROTECTIVE ROLE OF APOPTOSIS IN ASBESTOS PLEURAL INJURY
    V Broaddus; Fiscal Year: 2001
  2. SECRETED PHOSPHOPROTEINS ASSOCIATED WITH TUMORIGENICITY
    DONALD SENGER; Fiscal Year: 1993
  3. DISTRIBUTION AND FUNCTION OF THE INTEGRIN ANDYB8
    Stephen Nishimura; Fiscal Year: 1999
  4. Alpha v beta 5 integrin in retinal pigment epithelium
    SILVIA FINNEMANN; Fiscal Year: 2004
  5. The Integrin Ligand MFG-E8 and Photoreceptor Outer Segment Renewal.
    SILVIA FINNEMANN; Fiscal Year: 2007
  6. Integrin Activation in Breast Cancer Metastasis
    Brunhilde Felding Habermann; Fiscal Year: 2006
  7. MODULATION OF ALPHA 5 BETA 1 INTEGRIN
    David Boettiger; Fiscal Year: 2007
  8. Targeting Metastatic Breast Cancer with Human Antibodies
    Brunhilde Felding Habermann; Fiscal Year: 2009
  9. IVIS 200 Imaging System
    Brunhilde Felding Habermann; Fiscal Year: 2005
  10. Nanoparticle targeting of cathepsin-L inhibitor and doxorubicin in breast cancer
    Shaker Mousa; Fiscal Year: 2007

Detail Information

Publications189 found, 100 shown here

  1. ncbi Vitronectin and its receptors
    B Felding Habermann
    Department of Molecular and Experimental Medicine, Scripps Research Institute, La Jolla, California 92037
    Curr Opin Cell Biol 5:864-8. 1993
    ..protein vitronectin is recognized as an adhesive substrate by cells expressing at least one of four known vitronectin receptors: integrins alpha v beta 1, alpha v beta 3, alpha v beta 5 or alpha IIb beta 3...
  2. ncbi Solution structures and integrin binding activities of an RGD peptide with two isomers
    N Assa-Munt
    Cancer Research Center, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA
    Biochemistry 40:2373-8. 2001
    ..Solution structure analysis by nuclear magnetic resonance reveals an entirely different presentation of the RGD motif in the two isomers of RGD-4C. These results provide new insight into the ligand recognition specificity of integrins...
  3. ncbi Adhesion and migration of extracellular matrix-stimulated breast cancer
    John E Bartsch
    Department of Surgery, Medical College of Ohio, 3065 Arlington Avenue, Ohio 43614 5807, Toledo, USA
    J Surg Res 110:287-94. 2003
    ..We hypothesized that ECM binding to integrin receptors on breast cancer cells influenced cellular adhesion and migration...
  4. ncbi Biological and molecular properties of a new alpha(v)beta3/alpha(v)beta5 integrin antagonist
    Laura Belvisi
    Organic and Industrial Chemistry Department, Centre for Biomolecular Interdisciplinary Studies and Industrial Applications, University of Milan, Italy
    Mol Cancer Ther 4:1670-80. 2005
    ..Taken together, these observations indicate that ST1646 represents a dual alpha(v)beta3/alpha(v)beta5 integrin antagonist with interesting biochemical and biological features to be tested in cancer therapy...
  5. ncbi Requirement of vascular integrin alpha v beta 3 for angiogenesis
    P C Brooks
    Department of Immunology, Scripps Research Institute, La Jolla, CA 92037
    Science 264:569-71. 1994
    ..These findings suggest that alpha v beta 3 may be a useful therapeutic target for diseases characterized by neovascularization...
  6. ncbi Endothelial cell attachment and spreading on human tenascin is mediated by alpha 2 beta 1 and alpha v beta 3 integrins
    P Sriramarao
    La Jolla Institute for Experimental Medicine, CA 92037
    J Cell Sci 105:1001-12. 1993
    ....
  7. ncbi A signaling pathway from the alpha5beta1 and alpha(v)beta3 integrins that elevates bcl-2 transcription
    M L Matter
    Cancer Research Center, The Burnham Institute, La Jolla, California 92037, USA
    J Biol Chem 276:27757-63. 2001
    ..Mitogen-activated protein kinase did not appear to be necessary for the activation of bcl-2 transcription. Therefore, our work characterizes the pathway that mediates the effect of integrins on bcl-2 transcription and cell survival...
  8. pmc Src-mediated coupling of focal adhesion kinase to integrin alpha(v)beta5 in vascular endothelial growth factor signaling
    Brian P Eliceiri
    Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Cell Biol 157:149-60. 2002
    ..Our findings indicate that Src can coordinate specific growth factor and extracellular matrix inputs by recruiting integrin alpha(v)beta5 into a FAK-containing signaling complex during growth factor-mediated biological responses...
  9. pmc Thrombospondin cooperates with CD36 and the vitronectin receptor in macrophage recognition of neutrophils undergoing apoptosis
    J Savill
    Department of Medicine, Royal Postgraduate Medical School, Hammersmith Hospital, London, United Kingdom
    J Clin Invest 90:1513-22. 1992
    ..Our findings indicate newly defined roles for TSP and CD36 in phagocytic clearance of senescent neutrophils, which may limit inflammatory tissue injury and promote resolution...
  10. pmc Integrin alpha v beta 3 differentially regulates adhesive and phagocytic functions of the fibronectin receptor alpha 5 beta 1
    S D Blystone
    Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110
    J Cell Biol 127:1129-37. 1994
    ..In addition to its significance for phagocytosis, alpha v beta 3 regulation of alpha 5 beta 1 function may be significant for its roles in cell migration, metastasis, and angiogenesis...
  11. ncbi Eta-1 (osteopontin): an early component of type-1 (cell-mediated) immunity
    S Ashkar
    Laboratory for Skeletal Disorders and Rehabilitation, Department of Orthopedic Surgery, Children s Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA
    Science 287:860-4. 2000
    ..These findings identify Eta-1 as a key cytokine that sets the stage for efficient type-1 immune responses through differential regulation of macrophage IL-12 and IL-10 cytokine expression...
  12. pmc Integrin-associated protein immunoglobulin domain is necessary for efficient vitronectin bead binding
    F P Lindberg
    Department of Infectious Diseases, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Cell Biol 134:1313-22. 1996
    ..These data demonstrate that some alpha v integrin ligand-binding functions are IAP independent, whereas others require IAP, presumably through direct physical interaction between its Ig domain and the integrin...
  13. pmc Integrin beta 3 cytoplasmic tail is necessary and sufficient for regulation of alpha 5 beta 1 phagocytosis by alpha v beta 3 and integrin-associated protein
    S D Blystone
    Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Cell Biol 130:745-54. 1995
    ....
  14. pmc Focal adhesion kinase signaling promotes phagocytosis of integrin-bound photoreceptors
    Silvia C Finnemann
    Dyson Vision Research Institute, Department of Ophthalmology, Weill Medical College of Cornell University, New York, NY 10021, USA
    EMBO J 22:4143-54. 2003
    ..In contrast, inhibition of FAK signaling diminishes MerTK phosphorylation. These results demonstrate that FAK provides an essential link between binding and engulfment mechanisms of integrin-mediated phagocytosis...
  15. ncbi Integrin alpha v beta 3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels
    P C Brooks
    Department of Immunology, Scripps Research Institute, La Jolla, California 92037
    Cell 79:1157-64. 1994
    ..We demonstrate therefore that ligation of integrin alpha v beta 3 is required for the survival and maturation of newly forming blood vessels, an event essential for the proliferation of tumors...
  16. ncbi CD36 is required for phagocytosis of apoptotic cells by human macrophages that use either a phosphatidylserine receptor or the vitronectin receptor (alpha v beta 3)
    V A Fadok
    Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Immunol 161:6250-7. 1998
    ..A maximum of 70% inhibition was achieved by combining anti-CD36 with either anti-a(v) or PS liposomes...
  17. pmc NF-kappaB mediates alphavbeta3 integrin-induced endothelial cell survival
    M Scatena
    Department of Pathology, University of Washington, Seattle, Washington 98195, USA
    J Cell Biol 141:1083-93. 1998
    ..In contrast, inhibition of MEK and PI3-kinase did not affect osteopontin-induced NF-kappaB activation. These studies identify NF-kappaB as an important signaling molecule in alphavbeta3 integrin-mediated endothelial cell survival...
  18. pmc Integrin activation controls metastasis in human breast cancer
    B Felding-Habermann
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 98:1853-8. 2001
    ..Consequently, alterations within tumors that lead to the aberrant control of integrin activation are expected to adversely affect the course of human breast cancer...
  19. pmc PYK2 in osteoclasts is an adhesion kinase, localized in the sealing zone, activated by ligation of alpha(v)beta3 integrin, and phosphorylated by src kinase
    L T Duong
    Department of Bone Biology and Osteoporosis, Merck Research Laboratories, West Point, Pennsylvania 19486, USA
    J Clin Invest 102:881-92. 1998
    ..Taken together, these findings suggest that Src-dependent tyrosine phosphorylation of PYK2 is involved in the adhesion-induced formation of the sealing zone, required for osteoclastic bone resorption...
  20. ncbi Urokinase receptor interacts with alpha(v)beta5 vitronectin receptor, promoting urokinase-dependent cell migration in breast cancer
    M V Carriero
    National Cancer Institute, Naples, Italy
    Cancer Res 59:5307-14. 1999
    ..These data show that uPAR association with alpha(v)beta5 leads to a functional interaction of these receptors and suggest that uPAR directs cytoskeletal rearrangements and cell migration by altering alpha(v)beta5 signaling specificity...
  21. ncbi Peptide ligands for integrin alpha v beta 3 selected from random phage display libraries
    J M Healy
    Protein Engineering Research Institute, Osaka, Japan
    Biochemistry 34:3948-55. 1995
    ....
  22. pmc Requirement of the NPXY motif in the integrin beta 3 subunit cytoplasmic tail for melanoma cell migration in vitro and in vivo
    E J Filardo
    Department of Immunology, Scripps Research Institute, La Jolla, California 92037, USA
    J Cell Biol 130:441-50. 1995
    ..These findings demonstrate that the NPXY motif within the integrin beta 3 cytoplasmic tail is essential for alpha v beta 3-dependent post-ligand binding events involved in cell migration and the metastatic phenotype of melanoma cells...
  23. ncbi Disease-modifying activity of SB 273005, an orally active, nonpeptide alphavbeta3 (vitronectin receptor) antagonist, in rat adjuvant-induced arthritis
    A M Badger
    SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania 19406, USA
    Arthritis Rheum 44:128-37. 2001
    ..Measurements of paw inflammation and of bone, cartilage, and soft tissue structure indicated that this compound exerts a protective effect on joint integrity and thus appears to have disease-modifying properties...
  24. pmc The vitronectin receptor (alpha v beta 3) is implicated, in cooperation with P-selectin and platelet-activating factor, in the adhesion of monocytes to activated endothelial cells
    J F Murphy
    INSERM U331 Institut Pasteur de Lyon, , France
    Biochem J 304:537-42. 1994
    ..This study shows for the first time that alpha v beta 3 is implicated, in addition to P-selectin and PAF, in the adhesion of monocytes to activated endothelial cells...
  25. ncbi Phosphatidylinositol 3-kinase association with the osteoclast cytoskeleton, and its involvement in osteoclast attachment and spreading
    P T Lakkakorpi
    Department of Bone Biology and Osteoporosis Research, Merck Research Laboratory, West Point, Pennsylvania 19486, USA
    Exp Cell Res 237:296-306. 1997
    ..Finally, PI3-kinase coimmunoprecipitated with alpha v beta 3 integrin from osteoclasts...
  26. ncbi Emergence of alpha 5 beta 1 fibronectin- and alpha v beta 3 vitronectin-receptor expression in melanocytic tumour progression
    E H Danen
    Department of Pathology, University Hospital Nijmegen, The Netherlands
    Histopathology 24:249-56. 1994
    ..Our findings indicate that during melanoma progression alterations in integrin expression occur, the most striking being emergence of alpha 5 beta 1 fibronectin and alpha v beta 3 vitonectin receptor...
  27. pmc Differential alphav integrin-mediated Ras-ERK signaling during two pathways of angiogenesis
    John D Hood
    Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Cell Biol 162:933-43. 2003
    ..Thus, integrins alphavbeta3 and alphavbeta5 differentially regulate the Ras-ERK pathway, accounting for distinct vascular responses during two pathways of angiogenesis...
  28. ncbi A monoclonal antibody inhibits adhesion to fibronectin and vitronectin of a colon carcinoma cell line and recognizes the integrins alpha v beta 3, alpha v beta 5, and alpha v beta 6
    M Lehmann
    Institut de Chimie Biologique, ER CNRS 079, , France
    Cancer Res 54:2102-7. 1994
    ....
  29. ncbi Blocking monoclonal antibodies to alpha V beta 3 integrin: a unique epitope of alpha V beta 3 integrin is present on human osteoclasts
    A Chuntharapai
    Genentech Inc, South San Francisco, California 94080
    Exp Cell Res 205:345-52. 1993
    ..1.3 bound only weakly or not at all to tissues expressing alpha V beta 3 with the exception of osteoclasts. Thus, mAb 10C4.1.3 showed a very narrow tissue specificity being restricted to high-level expression on human osteoclasts...
  30. ncbi An angiogenic laminin site and its antagonist bind through the alpha(v)beta3 and alpha5beta1 integrins
    M L Ponce
    Craniofacial Developmental Biology and Regeneration Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892, USA
    FASEB J 15:1389-97. 2001
    ..Because the laminin gamma1 chain is ubiquitous in most tissues, C16 is likely an important functional site. Since the biological activity of C16 is blocked by a scrambled peptide, C16S may serve as an anti-angiogenic therapeutic agent...
  31. pmc Molecular cloning of integrin-associated protein: an immunoglobulin family member with multiple membrane-spanning domains implicated in alpha v beta 3-dependent ligand binding
    F P Lindberg
    Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110
    J Cell Biol 123:485-96. 1993
    ..When CHO cells are transfected with human IAP, monoclonal anti-human antibody completely inhibits vitronectin bead binding. These data suggest a model in which ligand binding by alpha v beta 3 is regulated by IAP...
  32. ncbi Vitronectin receptors, alpha v integrins, are recognized by several non-RGD-containing echoviruses in a continuous laboratory cell line and also in primary human Langerhans' islets and endothelial cells
    Petri Ylipaasto
    National Institute for Health and Welfare, Helsinki, Finland
    J Gen Virol 91:155-65. 2010
    ..receptor is also capable of binding the ligands by a non-RGD-dependent mechanism, we investigated whether vitronectin receptors, alpha v integrins, might act as receptors for other echoviruses that do not have the RGD motif...
  33. pmc Apoptosis of adherent cells by recruitment of caspase-8 to unligated integrins
    D G Stupack
    Department of Immunology and Department of Vascular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Cell Biol 155:459-70. 2001
    ..Integrin ligation disrupts this integrin-caspase containing complex and increases survival, revealing an unexpected role for integrins in the regulation of apoptosis and tissue remodeling...
  34. ncbi Functional overlap and cooperativity among alphav and beta1 integrin subfamilies during skin angiogenesis
    Carole A Perruzzi
    Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Invest Dermatol 120:1100-9. 2003
    ....
  35. ncbi A reevaluation of integrins as regulators of angiogenesis
    Richard O Hynes
    Howard Hughes Medical Institute and Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    Nat Med 8:918-21. 2002
    ..This apparent paradox suggests the hypotheses that these integrins are negative regulators of angiogenesis and that the drugs targeting them may be acting as agonists rather than antagonists...
  36. ncbi Enhanced pathological angiogenesis in mice lacking beta3 integrin or beta3 and beta5 integrins
    Louise E Reynolds
    Cell Adhesion and Disease Laboratory, Richard Dimbleby Department, Imperial Cancer Research Fund, St Thomas Hospital, London, UK
    Nat Med 8:27-34. 2002
    ....
  37. pmc Specific roles of the alpha V beta 1, alpha V beta 3 and alpha V beta 5 integrins in avian neural crest cell adhesion and migration on vitronectin
    M Delannet
    , Institut Jacques Monod, , France
    Development 120:2687-702. 1994
    ..cells expressed primarily the alpha V beta 1, alpha V beta 3 and alpha V beta 5 integrins as possible vitronectin receptors. Inhibition assays of cellular adhesion and migration with function-perturbing antibodies demonstrated ..
  38. pmc Differential roles of CD36 and alphavbeta5 integrin in photoreceptor phagocytosis by the retinal pigment epithelium
    S C Finnemann
    Margaret M Dyson Vision Research Institute, Department of Ophthalmology and Department of Cell Biology, Weill Medical College of Cornell University, New York, NY 10021, USA
    J Exp Med 194:1289-98. 2001
    ..They suggest that CD36 acts as a signaling molecule in postbinding steps of RPE phagocytosis independently of the OS binding receptor alphavbeta5 integrin...
  39. pmc Activation of alpha(v)beta3-vitronectin binding is a multistage process in which increases in bond strength are dependent on Y747 and Y759 in the cytoplasmic domain of beta3
    D Boettiger
    Department of Microbiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Mol Biol Cell 12:1227-37. 2001
    ..The Y747F mutant blocked the transition from stage 1 to stage 2, and the Y759F blocked the transition from stage 2 to stage 3. The data suggest a model for tension-induced activation of alpha(v)beta3 integrin...
  40. ncbi Multiple roles for platelet GPIIb/IIIa and alphavbeta3 integrins in tumor growth, angiogenesis, and metastasis
    Mohit Trikha
    Department of Biology Research, Centocor, Inc, 200 Great Valley Parkway, Malvern, PA 19355, USA
    Cancer Res 62:2824-33. 2002
    ..Collectively, these results indicate that combined blockade of GPIIb/IIIa and alphavbeta3 affords significant antiangiogenic and antitumor benefit...
  41. ncbi alpha v-Integrin antagonist EMD 121974 induces apoptosis in brain tumor cells growing on vitronectin and tenascin
    Takashi Taga
    Division of Hematology Oncology, Department of Pediatrics, Childrens Center for Cancer and Blood Diseases, Childrens Hospital Los Angeles, Los Angeles, CA 90027, USA
    Int J Cancer 98:690-7. 2002
    ..The dual action of this peptide explains its potent growth suppression of orthotopically transplanted brain tumors...
  42. pmc Integrin-mediated mechanotransduction requires its dynamic interaction with specific extracellular matrix (ECM) ligands
    S Jalali
    Department of Bioengineering and The Whitaker Institute of Biomedical Engineering, University of California, San Diego, La Jolla, CA 92093-0427, USA
    Proc Natl Acad Sci U S A 98:1042-6. 2001
    ..Our results indicate that the dynamic formation of new connections between integrins and their specific ECM ligands is critical in relaying the signals induced by shear stress to intracellular pathways...
  43. pmc Macrophage and retinal pigment epithelium phagocytosis: apoptotic cells and photoreceptors compete for alphavbeta3 and alphavbeta5 integrins, and protein kinase C regulates alphavbeta5 binding and cytoskeletal linkage
    S C Finnemann
    Department of Ophthalmology, Margaret M Dyson Vision Institute, New York, New York 10021, USA
    J Exp Med 190:861-74. 1999
    ..These data constitute the first evidence that noninflammatory phagocytes actively regulate the earliest phase of phagocytic clearance, particle binding, by controlling receptor activity...
  44. ncbi A mechanism for modulation of cellular responses to VEGF: activation of the integrins
    T V Byzova
    Joseph J Jacobs Center for Thrombosis and Vascular Biology, Department of Molecular Cardiology, Cleveland Clinic Foundation, Ohio 44195, USA
    Mol Cell 6:851-60. 2000
    ..Thus, integrin activation provides a mechanism for VEGF to induce a broad spectrum of cellular responses...
  45. ncbi Rac recruits high-affinity integrin alphavbeta3 to lamellipodia in endothelial cell migration
    W B Kiosses
    Department of Vascular Biology, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Nat Cell Biol 3:316-20. 2001
    ..By using WOW-1, we have identified the selective recruitment of high-affinity integrins as a mechanism by which lamellipodia promote formation of new adhesions at the leading edge in cell migration...
  46. ncbi Targeted antiangiogenic therapy for cancer using Vitaxin: a humanized monoclonal antibody to the integrin alphavbeta3
    J C Gutheil
    Department of Clinical Oncology Research, Sidney Kimmel Cancer Center, San Diego, California 92121, USA
    Clin Cancer Res 6:3056-61. 2000
    ..At the doses and schedule studied, Vitaxin appears safe and potentially active, suggesting that vascular integrin alphavbeta3 represents a clinically relevant antiangiogenic target for prolonged cancer therapy...
  47. pmc Plasmin-sensitive dibasic sequences in the third fibronectin-like domain of L1-cell adhesion molecule (CAM) facilitate homomultimerization and concomitant integrin recruitment
    S Silletti
    Department of Pediatrics, University of California at San Diego, La Jolla, California 92037, USA
    J Cell Biol 149:1485-502. 2000
    ....
  48. ncbi Tumstatin, an endothelial cell-specific inhibitor of protein synthesis
    Yohei Maeshima
    Program in Matrix Biology, Department of Medicine and the Cancer Center, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Science 295:140-3. 2002
    ..These results establish a role for integrins in mediating cell-specific inhibition of cap-dependent protein synthesis and suggest a potential mechanism for tumstatin's selective effects on endothelial cells...
  49. pmc Normal development, wound healing, and adenovirus susceptibility in beta5-deficient mice
    X Huang
    Lung Biology Center, University of California, San Francisco, San Francisco, California 94143 0854, USA
    Mol Cell Biol 20:755-9. 2000
    ..These data suggest that alphavbeta5 is not essential for normal development, reproduction, adenovirus infection, or the healing of cutaneous wounds...
  50. pmc Integrin alpha(v)beta1 is an adenovirus coreceptor
    E Li
    Department of Immunology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Virol 75:5405-9. 2001
    ....
  51. ncbi Canstatin acts on endothelial and tumor cells via mitochondrial damage initiated through interaction with alphavbeta3 and alphavbeta5 integrins
    Claire Magnon
    UMR 8121 Laboratoire de vectorologie et transfert de gènes, Institut Gustave Roussy, Villejuif Cedex, France
    Cancer Res 65:4353-61. 2005
    ..Taken together, these results provide insights into how canstatin might exert its strong anticancer effect...
  52. ncbi Superactivation of integrin alphavbeta3 by low antagonist concentrations
    D F Legler
    Institute of Biochemistry, University of Lausanne, CH-1066 Epalinges, Switzerland
    J Cell Sci 114:1545-53. 2001
    ..Our results indicate that low concentrations of the ligand mimetic cyclo-RGD can result in superactivation of the extracellular domain of integrin alphavbeta3 to a comparable level as activation by manganese...
  53. pmc Role of alphavbeta3 integrin in the activation of vascular endothelial growth factor receptor-2
    R Soldi
    Institute for Cancer Research and Treatment IRCC, Biology and Biochemistry, School of Medicine, University of Torino, 10100 Torino, Italy
    EMBO J 18:882-92. 1999
    ....
  54. pmc Focally regulated endothelial proliferation and cell death in human synovium
    D A Walsh
    Inflammation Group, Queen Mary and Westfield College, London, United Kingdom
    Am J Pathol 152:691-702. 1998
    ..Increased endothelial cell turnover may contribute to microvascular dysfunction and thereby facilitate persistent synovitis...
  55. ncbi Spatial organization of microfilaments and vitronectin receptor, alpha v beta 3, in osteoclasts. A study using confocal laser scanning microscopy
    P T Lakkakorpi
    Department of Anatomy, University of Oulu, Finland
    J Cell Sci 104:663-70. 1993
    ..abstract truncated at 250 words)..
  56. ncbi Involvement of tumor cell integrin alpha v beta 3 in hematogenous metastasis of human melanoma cells
    Brunhilde Felding-Habermann
    Department of Molecular and Experimental Medicine, Scripps Research Institute, Mail MEM 175, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Clin Exp Metastasis 19:427-36. 2002
    ....
  57. ncbi Proinflammatory cytokines potentiate thrombospondin-mediated phagocytosis of neutrophils undergoing apoptosis
    Y Ren
    Department of Medicine, University Hospital, Nottingham, UK
    J Immunol 154:2366-74. 1995
    ..Thus, M phi phagocytosis of apoptotic neutrophils can be potentiated by proinflammatory cytokines, suggesting a mechanism for negative feedback control of neutrophil number at inflamed sites...
  58. pmc Molecular pathway for cancer metastasis to bone
    Sarmishtha De
    Departments of Molecular Cardiology and Cardiology, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Biol Chem 278:39044-50. 2003
    ..Supporting this model, activated integrins were found to colocalize with VEGFR-2 in tissue samples of metastatic prostate tumors from patients...
  59. ncbi Purification and functional characterization of integrin alpha v beta 5. An adhesion receptor for vitronectin
    J W Smith
    Department of Immunology IMM13, Research Institute of Scripps Clinic, La Jolla, California 92037
    J Biol Chem 265:11008-13. 1990
    ..Secondly, polyclonal antibodies raised against alpha v beta 5 immunoprecipitate both beta 5 and beta x, and finally, the amino-terminal amino acid sequences of beta x and beta 5 are identical...
  60. pmc Insulin-like growth factor receptor cooperates with integrin alpha v beta 5 to promote tumor cell dissemination in vivo
    P C Brooks
    Department of Immunology, Scripps Research Institute, La Jolla, California 92037, USA
    J Clin Invest 99:1390-8. 1997
    ..These findings provide evidence that integrin ligation, in conjunction with cytokine activation, plays an important role in the dissemination of malignant tumor cells...
  61. pmc Integrin alpha v beta 3 rescues melanoma cells from apoptosis in three-dimensional dermal collagen
    A M Montgomery
    Department of Immunology, Scripps Research Institute, La Jolla, CA 92037
    Proc Natl Acad Sci U S A 91:8856-60. 1994
    ..These findings provide evidence that the survival and growth of transformed cells may be regulated by collagen degradation and integrin-dependent anchorage to this proteolysed matrix...
  62. ncbi The cell adhesion domain in plasma vitronectin is cryptic
    D Seiffert
    Department of Vascular Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Biol Chem 272:13705-10. 1997
    ..The data presented here indicate that such conformational changes in Vn are likely to occur in areas of tissue injury and thrombosis...
  63. ncbi Alpha v integrins as receptors for tumor targeting by circulating ligands
    R Pasqualini
    La Jolla Cancer Research Center, Burnham Institute, La Jolla, CA, USA RP ER
    Nat Biotechnol 15:542-6. 1997
    ....
  64. ncbi The alphavbeta3 integrin regulates alpha5beta1-mediated cell migration toward fibronectin
    K O Simon
    Department of Bone Biology and Osteoporosis, Merck Research Laboratories, West Point, Pennsylvania 19486, USA
    J Biol Chem 272:29380-9. 1997
    ..These findings demonstrate alphavbeta3 regulation of alpha5beta1-mediated cell migration and suggest that the beta3 transmembrane domain is essential for this function...
  65. ncbi The thrombospondin receptor integrin-associated protein (CD47) functionally couples to heterotrimeric Gi
    W A Frazier
    Departments of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 274:8554-60. 1999
    ..This functional coupling of CD47 to heterotrimeric G proteins provides a mechanistic explanation for the biological effects of CD47 in a wide variety of systems...
  66. ncbi Tumor regression by targeted gene delivery to the neovasculature
    John D Hood
    Department of Immunology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Science 296:2404-7. 2002
    ..Systemic injection of the NP into mice resulted in apoptosis of the tumor-associated endothelium, ultimately leading to tumor cell apoptosis and sustained regression of established primary and metastatic tumors...
  67. pmc The osteoclast functional antigen, implicated in the regulation of bone resorption, is biochemically related to the vitronectin receptor
    J Davies
    Imperial Cancer Research Fund, St Bartholomew s Hospital, London, UK
    J Cell Biol 109:1817-26. 1989
    ..These, and other, data provide the first indication of a function for the VNR and suggest that cell-cell and cell-extracellular matrix interactions involving integrins may play an important role in bone physiology...
  68. ncbi Syndecan-1 regulates alphavbeta5 integrin activity in B82L fibroblasts
    Kyle J McQuade
    Graduate Programs in Cellular and Molecular Biology, University of Wisconsin Madison, Madison, WI 53706, USA
    J Cell Sci 119:2445-56. 2006
    ..These results suggest that the ectodomain of the syndecan-1 core protein contains an active site that assembles into a complex with the alphavbeta5 integrin and regulates alphavbeta5 integrin activity...
  69. ncbi Different populations of macrophages use either the vitronectin receptor or the phosphatidylserine receptor to recognize and remove apoptotic cells
    V A Fadok
    National Jewish Center for Immunology and Respiratory Medicine, Denver, CO 80206
    J Immunol 149:4029-35. 1992
    ..These results suggest that the mechanism by which apoptotic cells are recognized and phagocytosed by macrophages is determined by the subpopulation of macrophages studied...
  70. pmc The adhesive and migratory effects of osteopontin are mediated via distinct cell surface integrins. Role of alpha v beta 3 in smooth muscle cell migration to osteopontin in vitro
    L Liaw
    Department of Pathology, University of Washington, Seattle 98195
    J Clin Invest 95:713-24. 1995
    ..Thus, interaction with distinct receptors is one mechanism by which osteopontin may initiate multiple functions...
  71. ncbi Inhibition of FGF-2-mediated chemotaxis of murine brain capillary endothelial cells by cyclic RGDfV peptide through blocking the redistribution of c-Src into focal adhesions
    T Shono
    Department of Urology, Nagasaki University School of Medicine, Sakamoto, Nagasaki, Japan
    Exp Cell Res 268:169-78. 2001
    ..Our results indicated that cRGDfV peptide inhibited redistribution of c-Src into focal adhesions, leading to impaired MAPK activation within focal adhesions and motility in FGF-2-treated endothelial cells...
  72. ncbi Stimulation of migration of human aortic smooth muscle cells by vitronectin: implications for atherosclerosis
    S L Brown
    Cardiovascular Division, Washington University School of Medicine, St Louis, MO 63110
    Cardiovasc Res 28:1815-20. 1994
    ....
  73. ncbi 99mTc-NC100692--a tracer for imaging vitronectin receptors associated with angiogenesis: a preclinical investigation
    David Edwards
    Research and Development, GE Healthcare, Medical Diagnostics, The Grove Centre, HP7 9LL Amersham, UK
    Nucl Med Biol 35:365-75. 2008
    ....
  74. ncbi The muscle-specific laminin receptor alpha7 beta1 integrin negatively regulates alpha5 beta1 fibronectin receptor function
    D Tomatis
    Dipartimento di Genetica, Biologia e Biochimica, Universita di Torino, Turin, 10126, Italy
    Exp Cell Res 246:421-32. 1999
    ..In conclusion, the data reported establish the existence of a negative cooperativity between alpha7 and alpha5 integrins that may be important in determining functional regulation of integrins during myogenic differentiation...
  75. ncbi The selective regulation of alpha Vbeta 1 integrin expression is based on the hierarchical formation of alpha V-containing heterodimers
    Pekka Koistinen
    MediCity Research Laboratory and the Department of Medical Biochemistry, Turku Graduate School of Biomedical Sciences, University of Turku, FIN 20520 Turku, Finland
    J Biol Chem 277:24835-41. 2002
    ..These observations explain how alphaVbeta1 can be specifically regulated without concomitant changes in the expression of other alphaV or beta1 integrins...
  76. ncbi Vitronectin receptors are expressed by macaque trophoblast cells and play a role in migration and adhesion to endothelium
    G C Douglas
    Department of Cell Biology and Human Anatomy, School of Medicine, University of California, Davis, CA 95616 8643, USA
    Biochim Biophys Acta 1452:36-45. 1999
    ..We sought to determine whether trophoblast cells isolated from early gestation macaque placentas expressed vitronectin receptors and tested the idea that these receptors play a role in trophoblast migration and adhesion...
  77. pmc Localisation of vitronectin receptor immunoreactivity and tartrate resistant acid phosphatase activity in synovium from patients with inflammatory or degenerative arthritis
    B A Ashton
    Department of Rheumatology, Robert Jones and Agnes Hunt Orthopaedic Hospital, Oswestry, United Kingdom
    Ann Rheum Dis 52:133-7. 1993
    ..The results show that fully differentiated osteoclasts are uncommon in synovium from patients with either degenerative or inflammatory arthropathies...
  78. ncbi A mechanism for divalent cation regulation of beta 3-integrins
    J W Smith
    Committee on Vascular Biology CVB 1, Scripps Research Institute, La Jolla, California 92037
    J Biol Chem 269:960-7. 1994
    ..Consequently, the data presented here suggest a mechanism in which two separate cation-binding sites regulate ligand binding to beta 3-integrins...
  79. ncbi Requirement of integrin beta3 tyrosine 747 for beta3 tyrosine phosphorylation and regulation of alphavbeta3 avidity
    S D Blystone
    Department of Medicine, Infectious Diseases Division, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 272:28757-61. 1997
    ..Because the motif in beta3 required for tyrosine phosphorylation is shared by several integrin beta-chains, this may be a conserved mechanism for regulation of integrin-dependent adhesion...
  80. ncbi Regulation of integrin-mediated adhesion at focal contacts by cyclic AMP
    W F Glass
    Department of Pathology, University of Texas Health Science Center at San Antonio
    J Cell Physiol 157:296-306. 1993
    ..Although other types of extracellular matrix receptors may also be involved, our observations suggest that cAMP regulates adhesion at focal contacts but not at fibronexus-type extracellular matrix contacts...
  81. ncbi RGD-mutants of B-lymphotropic polyomavirus capsids specifically bind to alpha(v)beta3 integrin
    J Langner
    Research Program Infection and Cancer, Deutsches Krebsforschungszentrum, Heidelberg, Germany
    Arch Virol 149:1877-96. 2004
    ..This selective binding of the mutant capsids could be inhibited by synthetic peptides that specifically bind to alpha(v)beta3 integrin with IC50 values between 10 and 40 nM...
  82. ncbi CAR is a cell-cell adhesion protein in human cancer cells and is expressionally modulated by dexamethasone, TNFalpha, and TGFbeta
    A Bruning
    Department of Obstetrics and Gynecology, Molecular Biology Laboratory, University of Freiburg, Hugstetter Strasse 55, D 79106 Freiburg, Germany
    Gene Ther 10:198-205. 2003
    ..In clinical cancer gene therapy, efficiency of adenoviral gene delivery could be altered by cell adhesion, TNFalpha, TGFbeta, and dexamethasone...
  83. ncbi Chemical adaptor immunotherapy: design, synthesis, and evaluation of novel integrin-targeting devices
    Lian Sheng Li
    The Skaggs Institute for Chemical Biology and Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    J Med Chem 47:5630-40. 2004
    ....
  84. ncbi Expression of the coxsackie and adenovirus receptor in human astrocytic tumors and xenografts
    Jonas Fuxe
    Ludwig Institute for Cancer Research, Stockholm Branch, Stockholm, Sweden
    Int J Cancer 103:723-9. 2003
    ..01). Two xenografts with low hCAR expression grew considerably faster than the hCAR-expressing cells. Our results have relevance for the use of adenoviruses in gene therapy against astrocytomas...
  85. ncbi On the mode of action of thrombin-induced angiogenesis: thrombin peptide, TP508, mediates effects in endothelial cells via alphavbeta3 integrin
    Nikos E Tsopanoglou
    Department of Pharmacology, Medical School, University of Patras, Rio Patras, Greece
    Thromb Haemost 92:846-57. 2004
    ..These results point to the importance of RGD sequence of thrombin in mediating effects on endothelial cells and angiogenesis...
  86. ncbi The pattern of enhancement of Src kinase activity on platelet-derived growth factor stimulation of glioblastoma cells is affected by the integrin engaged
    Qiang Ding
    Department of Pathology, Division of Neuropathology, The University of Alabama at Birmingham, 35294, USA
    J Biol Chem 278:39882-91. 2003
    ..Notably, the data indicate that engagement of different integrins alters the identity of the Src family members that are activated on stimulation with PDGF...
  87. ncbi Design, synthesis, and evaluation of radiolabeled integrin alpha v beta 3 receptor antagonists for tumor imaging and radiotherapy
    Thomas D Harris
    Discovery Research, Bristol Myers Squibb Medical Imaging, North Billerica, MA 01862, USA
    Cancer Biother Radiopharm 18:627-41. 2003
    ..Tumors are visible as early as 0.5 hours PI. Radiotherapy studies in the c-neu Oncomouse model demonstrated a slowing of tumor growth at a dose of 15 mCi/m(2), and a regression of tumors at a dose of 90 mCi/m(2)...
  88. ncbi Rac2 specificity in macrophage integrin signaling: potential role for Syk kinase
    De Pradip
    Section of Hematology Oncology, Department of Pediatrics, Biochemistry and Molecular Biology, Herman B Wells Center for Pediatric Research, School of Medicine of Indiana University, 1044 W Walnut Street, Indianapolis, IN 46202, USA
    J Biol Chem 278:41661-9. 2003
    ....
  89. ncbi Alphav-integrin utilization in human beta-cell adhesion, spreading, and motility
    Thomas Kaido
    Islet Research Laboratory at The Whittier Institute for Diabetes, Department of Pediatrics, The University of California at San Diego, La Jolla, California 92037, USA
    J Biol Chem 279:17731-7. 2004
    ..By supporting fetal beta-cell migration, alpha(v)beta(1) could play an important role in early motile processes required for islet neogenesis...
  90. ncbi The endoproteolytic processing of alphavbeta5 integrin is involved in cytoskeleton remodelling and cell migration
    Virginie Berthet
    CNRS UMR6032, Faculte de Pharmacie, 27 Bd J Moulin, 13385 Marseille Cedex 5, France
    FEBS Lett 557:159-63. 2004
    ..The alphav subunit cleavage is thus essential for integrin function and has a considerable impact on integrin-dependent events, especially those leading to cell migration...
  91. ncbi Alpha(v)beta3 and alpha(v)beta5 integrins bind both the proximal RGD site and non-RGD motifs within noncollagenous (NC1) domain of the alpha3 chain of type IV collagen: implication for the mechanism of endothelia cell adhesion
    Vadim Pedchenko
    Division of Nephrology, Veterans Affairs Hospital, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    J Biol Chem 279:2772-80. 2004
    ..Therefore, the RGD site, in addition to non-RGD motifs, may contribute to the mechanisms of endothelial cell adhesion in the human vasculature and the anti-angiogenic activity of the RGD-alpha3NC1 domain...
  92. ncbi alphav beta 3 and alphav beta 5 integrin antagonists inhibit angiogenesis in vitro
    Riccardo E Nisato
    Department of Morphology, University Medical Center, Geneva, Switzerland
    Angiogenesis 6:105-19. 2003
    ....
  93. ncbi Conditionally replicative adenovirus with tropism expanded towards integrins inhibits osteosarcoma tumor growth in vitro and in vivo
    Adhiambo M Witlox
    Department of Orthopedic Surgery, VU University Medical Center, Amsterdam, The Netherlands
    Clin Cancer Res 10:61-7. 2004
    ..The oncolytic capacity of the CRAd Ad5-Delta24RGD was tested on primary OS cells in vitro and in vivo...
  94. pmc Transglutaminase-mediated oligomerization of the fibrin(ogen) alphaC domains promotes integrin-dependent cell adhesion and signaling
    Alexey M Belkin
    University of Maryland School of Medicine, 15601 Crabbs Branch Way, Rockville, MD 20855, USA
    Blood 105:3561-8. 2005
    ..They also suggest a new role for transglutaminases in regulation of integrin-mediated adhesion and signaling via covalent modification of integrin ligands...
  95. ncbi Alphavbeta integrins play an essential role in BMP-2 induction of osteoblast differentiation
    Chung Fang Lai
    Division of Bone and Mineral Diseases, Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    J Bone Miner Res 20:330-40. 2005
    ..BMP-2 stimulates alphavbeta expression. BMP-2 receptors co-localize/overlap with alphavbeta integrins, and the intact function of alphavbeta is essential in BMP-2 activity...
  96. ncbi Blockade of alpha v beta3 and alpha v beta5 integrins by RGD mimetics induces anoikis and not integrin-mediated death in human endothelial cells
    Sylvie Maubant
    Centre National de Recherche Scientifique, Unité Mixte de Recherche CNRS UMR 6543, Centre Antoine Lacassagne, Nice, France
    Blood 108:3035-44. 2006
    ..Altogether, these findings have important implications for the development of this class of antiangiogenics...
  97. ncbi Cell surface overexpression of alphavbeta5 integrin impedes alphavbeta3-mediated migration of the human ovarian adenocarcinoma cell line IGROV1
    Sylvie Maubant
    GRECAN, Université de Caen Basse Normandie and Centre de Lutte Contre le Cancer François Baclesse, Avenue du General Harris, 14076 Caen Cedex 05, France
    Cell Biol Int 31:109-18. 2007
    ..Finally, the response to cisplatin was not significantly modified in beta5 transfectants when compared to IGROV1 parental cells...
  98. ncbi Synthesis and biological evaluation of new conformationally biased integrin ligands based on a tetrahydroazoninone scaffold
    Luca Banfi
    Department of Chemistry and Industrial Chemistry, Via Dodecaneso 31, 16146 Genova, Italy
    Bioorg Med Chem Lett 17:1341-5. 2007
    ..They exhibit interesting activity towards integrin alphaVbeta3 and a remarkable selectivity in comparison with integrin alphaVbeta5...
  99. pmc The lipoxygenase inhibitor, baicalein, modulates cell adhesion and migration by up-regulation of integrins and vinculin in rat heart endothelial cells
    Y C S Hsieh
    Graduate Institute of Chinese Pharmaceutical Sciences, China Medical University, Taichung, Taiwan, ROC
    Br J Pharmacol 151:1235-45. 2007
    ..We reported previously that baicalein strongly inhibited proliferation of rat heart endothelial cells and here we assess effects on migration and adhesion of these cells...
  100. ncbi Integrin alphavbeta6 mediates HT29-D4 cell adhesion to MMP-processed fibrinogen in the presence of Mn2+
    Francis Fouchier
    Laboratoire de Génie Génétique et Biotechnologie, INSERM 476, INRA 1260, Faculte de Pharmacie, 27 Bd Jean Moulin, F 13385 Marseille Cedex 5, France
    Eur J Cell Biol 86:143-60. 2007
    ..Finally, we found that Mn(2+) and activators of the ERK pathway cooperated in HT29-D4 cell adhesion to Fb. Such a process may be involved in bone metastasis of some cancer cells...
  101. ncbi Distinctive role of integrin-mediated adhesion in TNF-induced PKB/Akt and NF-kappaB activation and endothelial cell survival
    G Bieler
    Division of Experimental Oncology, Lausanne Cancer Centre, Epalinges, Switzerland
    Oncogene 26:5722-32. 2007
    ..The sensitizing effect of EMD121974 on TNF cytotoxicity may open new perspectives to the therapeutic use of TNF as anticancer agent...

Research Grants62

  1. PROTECTIVE ROLE OF APOPTOSIS IN ASBESTOS PLEURAL INJURY
    V Broaddus; Fiscal Year: 2001
    ..Then, she will determine the mechanisms by which certain signals, namely those initiated by vitronectin receptors, inhibit asbestos-induced apoptosis...
  2. SECRETED PHOSPHOPROTEINS ASSOCIATED WITH TUMORIGENICITY
    DONALD SENGER; Fiscal Year: 1993
    ..Sppl mediate their different effects via the same or different receptors and if they bind to vitronectin receptors. Finally, detailed immunohistochemical studies on the distribution of Sppl in human benign and malignant ..
  3. DISTRIBUTION AND FUNCTION OF THE INTEGRIN ANDYB8
    Stephen Nishimura; Fiscal Year: 1999
    ..How does the unique structure of beta8 relate to its function? Why does the melanoma cell express multiple vitronectin receptors and how does their expression correlate to the invasive phenotype? To answer these questions I will ..
  4. Alpha v beta 5 integrin in retinal pigment epithelium
    SILVIA FINNEMANN; Fiscal Year: 2004
    ..The mechanisms of these interactions and the unique localization of v5 integrin in RPE are conserved among species. Exploring the 5 null mouse is thus important to understand human disease. ..
  5. The Integrin Ligand MFG-E8 and Photoreceptor Outer Segment Renewal.
    SILVIA FINNEMANN; Fiscal Year: 2007
    ....
  6. Integrin Activation in Breast Cancer Metastasis
    Brunhilde Felding Habermann; Fiscal Year: 2006
    ....
  7. MODULATION OF ALPHA 5 BETA 1 INTEGRIN
    David Boettiger; Fiscal Year: 2007
    ..abstract_text> ..
  8. Targeting Metastatic Breast Cancer with Human Antibodies
    Brunhilde Felding Habermann; Fiscal Year: 2009
    ..Novel immunoconjugates containing small, highly toxic compounds will be tested for their effects on metastatic breast cancer. If successful, this work will contribute to an improvement of current anti-cancer treatment. ..
  9. IVIS 200 Imaging System
    Brunhilde Felding Habermann; Fiscal Year: 2005
    ..abstract_text> ..
  10. Nanoparticle targeting of cathepsin-L inhibitor and doxorubicin in breast cancer
    Shaker Mousa; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  11. GENETIC ANALYSIS OF RNA TUMOR VIRUSES
    David Boettiger; Fiscal Year: 2003
    ..This will be applied to analysis of the role of src in regulation of cytoskeletal structure and the linkage of cytoskeleton to integrin. ..
  12. Integrins and bone matrix in prostate cancer
    Tatiana Byzova; Fiscal Year: 2006
    ..abstract_text> ..
  13. 2006 Gordon Research Conference on Signal Transduction By Engineered ECM
    Michael Sheetz; Fiscal Year: 2006
    ..A special effort will be made to use the financial support requested to facilitate the attendance and participation of women and minorities in this meeting. [unreadable] [unreadable] [unreadable]..
  14. Genetic.Engin.Cells/Scaffolds for Bone Tissue Engineeri.
    Andres Garcia; Fiscal Year: 2006
    ..abstract_text> ..
  15. Cell type gene delivery and alcoholic liver disease
    Michael Wheeler; Fiscal Year: 2006
    ..In addition, through didactic training, and interactions with his mentor and key faculty, the applicant will acquire new skills that will allow him to become a successful member of the alcohol research community. ..
  16. Ceramide in angiogenic integrin signaling
    Anat Erdreich Epstein; Fiscal Year: 2006
    ....
  17. CD47/IAP Modulation of Immune Cell Functions
    William Frazier; Fiscal Year: 2006
    ..3. Use CD47 null mice to define the role of CD47 in development of immune cells, in class switching during an immune response and in autoimmunity. ..
  18. A MULTI-USE GLIOMA BIOREPOSITORY
    Tom Mikkelsen; Fiscal Year: 2006
    ..We seek support to expand this multi-use glioma biorepository into an ongoing resource of the best characterized glioma material with clinical correlative and genomic data available. ..
  19. Does FAK mediate implant microtopography
    Galen Schneider; Fiscal Year: 2006
    ..This would allow for a controlled, localized, site specific tissue engineering approach in association with Dental implant therapy. ..
  20. SYNOVIAL DYSFUNCTION DUE TO P53 ABNORMALITIES IN RA
    Gary Firestein; Fiscal Year: 2006
    ..abstract_text> ..
  21. Biophysical Properties of Membranes: Lipid-Protein Bonds
    Michael Sheetz; Fiscal Year: 2006
    ..abstract_text> ..
  22. Nanostructure Devices for Measuring Cell Mechanics
    Michael Sheetz; Fiscal Year: 2009
    ..These studies have many practical applications in tissue engineering and in designing potential therapies for wound healing, cancer and a variety of disorders. ..
  23. HIV-1 gp120-mediated injury in brain endothelium
    Shalom Avraham; Fiscal Year: 2009
    ..These studies should provide insights into preventive and/or therapeutic strategies to sustain BBB integrity in HIV-infected patients, and thereby contribute to limiting CNS pathology. ..
  24. STRUCTURE AND ASSEMBLY OF CYTOSKELETAL FILAMENTS
    Michael Sheetz; Fiscal Year: 2009
    ....
  25. FLOW EFFECTS ON ENDOTHELIAL/TROPHOBLAST INTERACTION
    GORDON DOUGLAS; Fiscal Year: 2008
    ..FSSinduced trophoblast migration will be quantified in cells in which MUC1 internalization has been blocked. ..
  26. FGF RECEPTOR SIGNALING IN BONE DEVELOPMENT
    Joseph Schlessinger; Fiscal Year: 2009
    ....
  27. Glucocorticoids and Programming of the Hypertensive Vascular Phenotype
    Omid Khorram; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  28. Resolution of Gouty Inflammation
    STEPHEN MALAWISTA; Fiscal Year: 2008
    ..We suggest further that this reprogramming of lipid mediators may explain in part the action of therapeutic agents such as colchicine, and could lead to better treatment for this condition. [unreadable] [unreadable] [unreadable]..
  29. Brain tumor angiogenesis: Integrin ceramide signaling
    Anat Erdreich Epstein; Fiscal Year: 2008
    ..abstract_text> ..
  30. Integrin-specific implant surfaces for bone repair
    Andres Garcia; Fiscal Year: 2008
    ..Collectively, these studies will validate this biomolecular surface engineering approach for developing biologically active implants for enhanced bone repair. ..
  31. NEW APPLICATIONS IN BRAIN TUMOR THERAPY
    Tom Mikkelsen; Fiscal Year: 2008
    ..These efforts speak to the ultimate goal of our group and NABTT Consortium: improving the outcome of brain tumor patients. ..
  32. Gas6/Mertk mediated phagocytosis of OS by RPE cells
    Michael Hall; Fiscal Year: 2005
    ..abstract_text> ..
  33. TAP20, NOVEL INTEGRIN MODULATING PROTEIN
    Shaoqing Tang; Fiscal Year: 2001
    ..We anticipate that these studies should provide data that will be useful in designing new strategic for pharmacologic intervention in ischemic vascular disease and cancer. ..
  34. PHOSPHATIDYLSERINE-SPECIFIC RECEPTOR FOR APOPTOTIC CELLS
    Valerie Fadok; Fiscal Year: 2004
    ..The investigators hypothesize that PS recognition has been preserved throughout phylogeny as an effective mechanism mediating the removal of apoantibodies. ..
  35. LEUKOCYTE INTEGRIN ALPHA M BETA 2
    Edward Plow; Fiscal Year: 2004
    ....
  36. THE STRUCTURE AND FUNCTION OF PLATELET GPIIB-IIIA
    Edward Plow; Fiscal Year: 2003
    ..At the same time, these studies may have direct bearing on the use and future development of the GPIIb-IIIa blockers as antithrombotic agents. ..
  37. LYME DISEASE--HOST PARASITE INTERACTIONS
    STEPHEN MALAWISTA; Fiscal Year: 2003
    ..These studies may provide the technical and conceptual basis for improvements in diagnostic and prognostic aspects of inflammatory diseases. ..
  38. INTEGRIN ANTAGONISTS IN GLIOMA BIOLOGY, IMAGING, THERAPY
    Tom Mikkelsen; Fiscal Year: 2003
    ..abstract_text> ..
  39. MOLECULAR BASIS OF ORGANELLE MOVEMENT IN AXONS
    Michael Sheetz; Fiscal Year: 2002
    ....
  40. ROLE OF THE NUCLEAR MATRIX PROTEIN NRB/B IN BRAIN
    Shalom Avraham; Fiscal Year: 2002
    ..These studies should provide novel insights into the role of this nuclear matrix protein in neuronal differentiation. ..
  41. INTERACTION OF OSTEOPONTIN WITH ADHESION RECEPTORS
    JOEL BENNETT; Fiscal Year: 2002
    ..Our results suggest that it may be possible to inhibit the formation of platelet thrombi in arteries involved by atherosclerosis by preventing the interaction of platelet alphavbeta3 with osteopontin. ..
  42. REGULATION OF PERIPHERAL INFLAMMATION BY THE CNS
    Gary Firestein; Fiscal Year: 2002
    ..These studies will provide a basis for understanding the central nervous system-immune system connection as well as explore novel therapeutic targets. ..
  43. REGULATION OF ANGIOGENESIS BY THROMBOSPONDIN
    William Frazier; Fiscal Year: 2004
    ..The TSP/CD36 system provides a normally functioning entre into the control of angiogenesis in which the ligand and receptor are well defined and whose mechanism will be elucidated as indicated above. ..
  44. MACAQUE IN VITRO IMPLANTATION MODEL
    GORDON DOUGLAS; Fiscal Year: 2004
    ..Specific Aim 3 will use neutralizing antibodies and immobilized recombinant chemokines to characterize the role of chemokines in regulating expression of trophoblast migratory phenotypic markers and blastocyst development. ..
  45. IKKi expression and regulation in rheumatoid arthritis
    Gary Firestein; Fiscal Year: 2005
    ..We propose to test the hypothesis that IKKi is an important signal transduction pathway that regulates inflammation in chronic arthritis and is a novel target for development of anti-rheumatic agents. ..
  46. CELL SURFACE STRUCTURE AND TRANSFORMATIONS
    Richard Hynes; Fiscal Year: 2005
    ..Evaluation of the functions of cell adhesion proteins and the consequences of their misexpression in metastatic cells will lead to new leads for therapeutic interventions against metastasis. ..
  47. 2004 Hemostasis Gordon Research Conference
    Edward Plow; Fiscal Year: 2004
    ..The Hemostasis Gordon Conference has been a highly successful and enjoyable meeting, frequently identified as the best meeting attended by participants; and we believe that the current program has the potential to extend this tradition. ..
  48. ENDOTHELIAL SIGNALING MECHANISMS IN LUNG INJURY
    Sunita Bhattacharya; Fiscal Year: 2005
    ..These mechanisms are highly relevant to the general understanding of the lung inflammatory response. No previous understanding of these mechanisms exists for lung endothelium in vivo. The proposed studies will be novel. ..
  49. MOLECULAR GLIOMA THERAPIES AND DIAGNOSTICS
    Tom Mikkelsen; Fiscal Year: 2004
    ..abstract_text> ..
  50. Thrombospondins and Atherothrombosis
    Edward Plow; Fiscal Year: 2004
    ..Together, these studies should provide a rigorous test of the hypothesis and extend our knowledge of the roles of the TSPs in cardiovascular biology. ..
  51. Molecular Mechanisms That Regulate CD11d Expression
    JOHN NOTI; Fiscal Year: 2004
    ..Transgenic analysis of the CD11d cis elements will be done to complement these studies. These studies will expand our understanding of normal myeloid development and leukemogenesis. ..
  52. Single Fiber Forces from Cardiac Fibroblasts
    Michael Sheetz; Fiscal Year: 2004
    ..abstract_text> ..
  53. Anthrax Vaccine Formulations Combining PA/Spore Epitopes
    AAIYAPPA PALECANDA; Fiscal Year: 2005
    ..Significance: This research is relevant to the potential to develop novel vaccine formulations and therapeutics to counter inhalation anthrax. ..
  54. Docking protein FRS2 in FGF signaling
    Joseph Schlessinger; Fiscal Year: 2008
    ..abstract_text> ..
  55. Integrins and Orthodontic Tooth Movement
    Calogero Dolce; Fiscal Year: 2002
    ..Aim 2 experiments will assess the rate and extent of alveolar bone turnover using histomorphometric means. These data may demonstrate the usefulness of the RGD peptide in modulating both bone formation and resorption during OTM. ..
  56. AUTOIMMUNE THROMBOCYTOPENIA
    Robert McMillan; Fiscal Year: 2002
    ..Results of these studies will be correlated with the patients' clinical course and thrombopoietin levels. In addition, the effect of immune thrombocytopenia on the patients' quality of life will be studied. ..
  57. Human Endometrial Nitric Oxide: Regulation and Function
    Omid Khorram; Fiscal Year: 2003
    ..This pilot study should shed light on regulation and function of human endometrial NO pathway, an uninvestigated area of research with profound clinical significance. ..
  58. Mineralization: Integrins and Focal Adhesion Kinase
    Galen Schneider; Fiscal Year: 2003
    ..This will allow for development of new therapeutic approaches that in turn could lead to novel treatments and tissue-engineered biological applications to increase the quality of life for many patients. ..
  59. Fragments of TrpRS to Treat Neovascular Eye Diseases
    Martin Friedlander; Fiscal Year: 2006
    ..abstract_text> ..
  60. CORE GRANT FOR VISION RESEARCH
    Martin Friedlander; Fiscal Year: 2005
    ..abstract_text> ..