integrin beta chains

Summary

Summary: Integrin beta chains combine with integrin alpha chains to form heterodimeric cell surface receptors. Integrins have traditionally been classified into functional groups based on the identity of one of three beta chains present in the heterodimer. The beta chain is necessary and sufficient for integrin-dependent signaling. Its short cytoplasmic tail contains sequences critical for inside-out signaling.

Top Publications

  1. ncbi Fas activation induces renal tubular epithelial cell beta 8 integrin expression and function in the absence of apoptosis
    George Jarad
    Department of Medicine, Rammelkamp Center for Education and Research, MetroHealth Medical Center Campus, Case Western Reserve University School of Medicine, Cleveland, Ohio 44109 1998, USA
    J Biol Chem 277:47826-33. 2002
  2. ncbi Alpha 4 beta 7 integrin mediates lymphocyte binding to the mucosal vascular addressin MAdCAM-1
    C Berlin
    Department of Pathology, Stanford University, California 94305
    Cell 74:185-95. 1993
  3. pmc The Structure of the talin head reveals a novel extended conformation of the FERM domain
    Paul R Elliott
    School of Biological Sciences, University of Liverpool, Crown Street, Liverpool, L69 7ZB, UK
    Structure 18:1289-99. 2010
  4. ncbi Beta7 integrin-deficient mice: delayed leukocyte recruitment and attenuated protective immunity in the small intestine during enteric helminth infection
    D Artis
    Immunology Group, School of Biological Sciences, University of Manchester, GB
    Eur J Immunol 30:1656-64. 2000
  5. ncbi Talin binding to integrin beta tails: a final common step in integrin activation
    Seiji Tadokoro
    Department of Cell Biology, The Scripps Research Institute, The Burnham Institute, La Jolla, CA 92037, USA
    Science 302:103-6. 2003
  6. ncbi Role of β5-integrin in epithelial-mesenchymal transition in response to TGF-β
    Anna Bianchi
    Department of Cancer Genetics, Roswell Park Cancer Institute, Buffalo, NY, USA
    Cell Cycle 9:1647-59. 2010
  7. ncbi Role of the beta1-integrin subunit in the adhesion, extravasation and migration of T24 human bladder carcinoma cells
    Christoph Heyder
    Institute of Immunology, Witten Herdecke University, 58448 Witten, Germany
    Clin Exp Metastasis 22:99-106. 2005
  8. pmc Distribution and evolution of von Willebrand/integrin A domains: widely dispersed domains with roles in cell adhesion and elsewhere
    Charles A Whittaker
    Howard Hughes Medical Institute, Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Mol Biol Cell 13:3369-87. 2002
  9. pmc Tailored integrin-extracellular matrix interactions to direct human mesenchymal stem cell differentiation
    Jessica Ellen Frith
    Tissue Engineering and Microfluidics Laboratory, Australian Institute for Bioengineering and Nanotechnology, University of Queensland, St Lucia, Queensland, Australia
    Stem Cells Dev 21:2442-56. 2012
  10. ncbi Mechanisms that regulate adaptor binding to beta-integrin cytoplasmic tails
    Kyle R Legate
    Department of Molecular Medicine, Max Planck Institute of Biochemistry, Martinsried, Germany
    J Cell Sci 122:187-98. 2009

Detail Information

Publications206 found, 100 shown here

  1. ncbi Fas activation induces renal tubular epithelial cell beta 8 integrin expression and function in the absence of apoptosis
    George Jarad
    Department of Medicine, Rammelkamp Center for Education and Research, MetroHealth Medical Center Campus, Case Western Reserve University School of Medicine, Cleveland, Ohio 44109 1998, USA
    J Biol Chem 277:47826-33. 2002
    ..We conclude that alpha(v)beta(8) integrin induction defines an unexpected role for Fas in cell migration, rather than as a cell death receptor...
  2. ncbi Alpha 4 beta 7 integrin mediates lymphocyte binding to the mucosal vascular addressin MAdCAM-1
    C Berlin
    Department of Pathology, Stanford University, California 94305
    Cell 74:185-95. 1993
    ..Alpha 4 beta 7 can also bind VCAM-1, but this requires greater integrin activation than binding to MAdCAM-1. The findings imply a selective role for the interaction of alpha 4 beta 7 and MAdCAM-1 lymphocyte in homing to mucosal sites...
  3. pmc The Structure of the talin head reveals a novel extended conformation of the FERM domain
    Paul R Elliott
    School of Biological Sciences, University of Liverpool, Crown Street, Liverpool, L69 7ZB, UK
    Structure 18:1289-99. 2010
    ....
  4. ncbi Beta7 integrin-deficient mice: delayed leukocyte recruitment and attenuated protective immunity in the small intestine during enteric helminth infection
    D Artis
    Immunology Group, School of Biological Sciences, University of Manchester, GB
    Eur J Immunol 30:1656-64. 2000
    ..Furthermore, these results suggest that beta7 integrin-independent adhesion molecule interactions are deployed in the large but not small intestine during intestinal inflammation...
  5. ncbi Talin binding to integrin beta tails: a final common step in integrin activation
    Seiji Tadokoro
    Department of Cell Biology, The Scripps Research Institute, The Burnham Institute, La Jolla, CA 92037, USA
    Science 302:103-6. 2003
    ..Thus, regulated binding of talin to integrin beta tails is a final common element of cellular signaling cascades that control integrin activation...
  6. ncbi Role of β5-integrin in epithelial-mesenchymal transition in response to TGF-β
    Anna Bianchi
    Department of Cancer Genetics, Roswell Park Cancer Institute, Buffalo, NY, USA
    Cell Cycle 9:1647-59. 2010
    ..Finally, depletion of β5-integrin significantly reduced invasiveness of breast carcinoma cells. Thus, the β5-integrin adhesions contribute to the TGFβ-induced EMT and the tumorigenic potential of carcinoma cells...
  7. ncbi Role of the beta1-integrin subunit in the adhesion, extravasation and migration of T24 human bladder carcinoma cells
    Christoph Heyder
    Institute of Immunology, Witten Herdecke University, 58448 Witten, Germany
    Clin Exp Metastasis 22:99-106. 2005
    ..Our observations strongly suggest a central role for the beta(1)-integrin subunit in forming the cell-cell and cell-matrix bonds necessary for adhesion, extravasation and migration...
  8. pmc Distribution and evolution of von Willebrand/integrin A domains: widely dispersed domains with roles in cell adhesion and elsewhere
    Charles A Whittaker
    Howard Hughes Medical Institute, Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Mol Biol Cell 13:3369-87. 2002
    ..These allow inferences about similar functions in novel situations such as protease regulators (e.g., complement factors and trypsin inhibitors) and intracellular proteins (e.g., helicases, chelatases, and copines)...
  9. pmc Tailored integrin-extracellular matrix interactions to direct human mesenchymal stem cell differentiation
    Jessica Ellen Frith
    Tissue Engineering and Microfluidics Laboratory, Australian Institute for Bioengineering and Nanotechnology, University of Queensland, St Lucia, Queensland, Australia
    Stem Cells Dev 21:2442-56. 2012
    ..This platform also provides information for the development of biomaterials capable of directing hMSC differentiation for use in tissue engineering therapies...
  10. ncbi Mechanisms that regulate adaptor binding to beta-integrin cytoplasmic tails
    Kyle R Legate
    Department of Molecular Medicine, Max Planck Institute of Biochemistry, Martinsried, Germany
    J Cell Sci 122:187-98. 2009
    ....
  11. ncbi The regulation mechanism for the auto-inhibition of binding of human filamin A to integrin
    Ulla Pentikäinen
    Department of Biological and Environmental Science, University of Jyvaskyla, Jyvaskyla, Finland
    J Mol Biol 393:644-57. 2009
    ..This observed force-induced conformational change can also be one of possible mechanisms involved in the regulation of integrin activation...
  12. ncbi Memory CCR6+CD4+ T cells are preferential targets for productive HIV type 1 infection regardless of their expression of integrin β7
    Patricia Monteiro
    Department of Microbiology and Immunology, University of Montreal, Montreal, H3C 3J7 Quebec, Canada
    J Immunol 186:4618-30. 2011
    ....
  13. ncbi Cell-cell adhesion via the ECM: integrin genetics in fly and worm
    N H Brown
    Wellcome CRC Institute and Department of Anatomy, University of Cambridge, Tennis Court Rd, CB2 1QR, Cambridge, UK
    Matrix Biol 19:191-201. 2000
    ..The continued use of genetic approaches to identify proteins required for integrin function in these two model organisms should lead to the identification of the minimal set of conserved components that form integrin adhesive structures...
  14. pmc Treatment of radioresistant stem-like esophageal cancer cells by an apoptotic gene-armed, telomerase-specific oncolytic adenovirus
    Xiaochun Zhang
    Department of Radiation Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 14:2813-23. 2008
    ..Because CSCs require telomerase to proliferate, a telomerase-specific oncolytic adenoviral vector carrying apoptotic tumor necrosis factor-related apoptosis-inducing ligand and E1A gene (Ad/TRAIL-E1) may preferentially target CSCs...
  15. ncbi A direct test of potential roles for beta3 and beta5 integrins in growth and metastasis of murine mammary carcinomas
    Daniela Taverna
    Howard Hughes Medical Institute, Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Cancer Res 65:10324-9. 2005
    ..These data indicate that alphavbeta3 or alphavbeta5 integrins are not essential for tumor growth and progression, although they might play some role in mammary gland development...
  16. pmc Src kinase activation by direct interaction with the integrin beta cytoplasmic domain
    Elena G Arias-Salgado
    Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 100:13298-302. 2003
    ..The data provide a paradigm for integrin regulation of Src and a molecular basis for the similar functional defects of osteoclasts or platelets from mice lacking beta3 integrins or c-Src...
  17. ncbi Integrins on eggs: the betaC subunit is essential for formation of the cortical actin cytoskeleton in sea urchin eggs
    Robert D Burke
    Departments of Biology and Biochemistry Microbiology, University of Victoria, Victoria, BC, Canada
    Dev Biol 265:53-60. 2004
    ..These studies demonstrate that the cortical actin cytoskeleton is anchored by betaC integrins and contractile ring actin is not. We suggest that one important function of egg integrins is to organize the actin cortex...
  18. ncbi Connections between integrins and Rac GTPase pathways control gonad formation and function in C. elegans
    Myeongwoo Lee
    Department of Biology, Baylor University, One Bear Place 97388, Waco, TX 76798, United States
    Biochim Biophys Acta 1723:248-55. 2005
    ..Furthermore, data showing distinct phenotypes of HA-betatail with unc-73 versus ced-5 suggest some tissue-specificity in the usage of Rac signaling pathways...
  19. ncbi Pl-nectin, a discoidin family member, is a ligand for betaC integrins in the sea urchin embryo
    Francesca Zito
    Consiglio Nazionale delle Ricerche, Istituto di Biomedicina e Immunologia Molecolare Alberto Monroy, Via Ugo La Malfa 153, Palermo, Italy
    Matrix Biol 29:341-5. 2010
    ....
  20. pmc Egg integrins: back in the game of mammalian fertilization
    Janice P Evans
    Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, 615 N Wolfe St, Baltimore, MD 21205, USA
    ACS Chem Biol 4:321-3. 2009
    ..Recent data provide insights into the function of egg integrins in mammalian fertilization and address some of the controversies regarding the involvement of these molecules in sperm-egg interaction...
  21. pmc Kindlin-1 and -2 directly bind the C-terminal region of beta integrin cytoplasmic tails and exert integrin-specific activation effects
    David S Harburger
    Department of Pharmacology and Interdepartmental Program in Vascular Biology and Transplantation, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Biol Chem 284:11485-97. 2009
    ..We suggest that kindlins are adaptor proteins that regulate integrin activation, that kindlin expression levels determine their effects, and that kindlins may exert integrin-specific effects...
  22. ncbi Blood-borne human plasma cells in steady state are derived from mucosal immune responses
    Henrik E Mei
    Center for Tumor Medicine, Institute of Transfusion Medicine, Charite University Hospital, Berlin, Germany
    Blood 113:2461-9. 2009
    ..Systemic vaccination does not impact on peripheral IgA(+) plasmablast numbers, indicating that mucosal and systemic humoral immune responses are regulated independent of each other...
  23. pmc Structural basis for the autoinhibition of talin in regulating integrin activation
    Esen Goksoy
    Department of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Mol Cell 31:124-33. 2008
    ..These data define a distinct autoinhibition mechanism for talin and suggest how it controls integrin activation and cell adhesion...
  24. ncbi The N-terminal SH2 domains of Syk and ZAP-70 mediate phosphotyrosine-independent binding to integrin beta cytoplasmic domains
    Darren G Woodside
    Division of Vascular Biology, Department of Cell Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Biol Chem 277:39401-8. 2002
    ..Thus, the binding of Syk and ZAP-70 to integrin beta cytoplasmic domains represents a novel phosphotyrosine-independent interaction mediated by their N-terminal SH2 domains...
  25. pmc Beta8 integrin binds Rho GDP dissociation inhibitor-1 and activates Rac1 to inhibit mesangial cell myofibroblast differentiation
    Sujata Lakhe-Reddy
    Department of Medicine, Case Western Reserve University School of Medicine, Rammelkamp Center for Education and Research, MetroHealth Medical Center, Cleveland, Ohio 44109, USA
    J Biol Chem 281:19688-99. 2006
    ....
  26. pmc Novel role for alphavbeta5-integrin in retinal adhesion and its diurnal peak
    Emeline F Nandrot
    Margaret M Dyson Vision Research Institute, Department of Ophthalmology, Weill Medical College of Cornell University, 1300 York Ave, New York, NY 10021, USA
    Am J Physiol Cell Physiol 290:C1256-62. 2006
    ..Furthermore, they indicate that alpha(v)beta(5) receptors at the same apical plasma membrane domain of RPE cells fulfill two separate functions that are synchronized by different diurnal rhythms...
  27. ncbi A fundamental subdivision of circulating lymphocytes defined by adhesion to mucosal addressin cell adhesion molecule-1. Comparison with vascular cell adhesion molecule-1 and correlation with beta 7 integrins and memory differentiation
    L S Rott
    Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University, CA 94305
    J Immunol 156:3727-36. 1996
    ....
  28. pmc Extracellular matrix-mediated tissue remodeling following axial movement of teeth
    Xianghong Luan
    Department of Oral Biology, University of Illinois at Chicago College of Dentistry, Chicago, IL 60612, USA
    J Histochem Cytochem 55:127-40. 2007
    ....
  29. ncbi The integrin alphavbeta6 is critical for keratinocyte migration on both its known ligand, fibronectin, and on vitronectin
    X Huang
    Lung Biology Center, Cardiovascular Research Institute, Center for Occupational and Environmental Health and Department of Medicine, University of California, San Francisco, USA
    J Cell Sci 111:2189-95. 1998
    ....
  30. ncbi Critical role for beta7 integrins in formation of the gut-associated lymphoid tissue
    N Wagner
    Institute for Genetics, University of Cologne, Germany
    Nature 382:366-70. 1996
    ..This is probably due to a failure of beta7-/- lymphocytes to arrest and adhere to the vasculature at the site of transmigration into the GALT...
  31. pmc Loss of synchronized retinal phagocytosis and age-related blindness in mice lacking alphavbeta5 integrin
    Emeline F Nandrot
    Margaret M Dyson Vision Research Institute, Department of Ophthalmology, Weill Medical College of Cornell University, 1300 York Ave, New York, NY 10021, USA
    J Exp Med 200:1539-45. 2004
    ..Furthermore, they identify the beta5-/- integrin mouse strain as a new animal model of age-related retinal dysfunction...
  32. pmc Induction of an epithelial integrin alphavbeta6 in human cytomegalovirus-infected endothelial cells leads to activation of transforming growth factor-beta1 and increased collagen production
    Takako Tabata
    Department of Cell and Tissue Biology, University of California San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143 0640, USA
    Am J Pathol 172:1127-40. 2008
    ..Our results suggest that activation of TGF-beta1 by integrin alphavbeta6 contributes to pathological changes and may impair endothelial cell functions in tissues that are chronically infected with CMV...
  33. ncbi Enhanced pathological angiogenesis in mice lacking beta3 integrin or beta3 and beta5 integrins
    Louise E Reynolds
    Cell Adhesion and Disease Laboratory, Richard Dimbleby Department, Imperial Cancer Research Fund, St Thomas Hospital, London, UK
    Nat Med 8:27-34. 2002
    ....
  34. ncbi The molecular basis of filamin binding to integrins and competition with talin
    Tiila Kiema
    Biocenter Oulu, Department of Biochemistry, University of Oulu, FIN 90014 Oulu, Finland
    Mol Cell 21:337-47. 2006
    ..Phosphothreonine-mimicking mutations inhibit filamin, but not talin, binding, indicating that kinases may modulate this competition and provide additional means to control integrin functions...
  35. pmc A virus-encoded telomerase RNA promotes malignant T cell lymphomagenesis
    Sascha Trapp
    Department of Microbiology and Immunology, Cornell University, Ithaca, NY 14853, USA
    J Exp Med 203:1307-17. 2006
    ..We concluded that vTR plays a critical role in MDV-induced T cell lymphomagenesis. Furthermore, our results provide the first description of tumor-promoting effects of TR in a natural virus-host infection model...
  36. ncbi Increased filamin binding to beta-integrin cytoplasmic domains inhibits cell migration
    D A Calderwood
    Department of Vascular Biology, The Scripps Research Institute, 10550 N Torrey Pines Rd, La Jolla, California 92037, USA
    Nat Cell Biol 3:1060-8. 2001
    ..Thus, tight filamin binding restricts integrin-dependent cell migration by inhibiting transient membrane protrusion and cell polarization...
  37. pmc Normal development, wound healing, and adenovirus susceptibility in beta5-deficient mice
    X Huang
    Lung Biology Center, University of California, San Francisco, San Francisco, California 94143 0854, USA
    Mol Cell Biol 20:755-9. 2000
    ..These data suggest that alphavbeta5 is not essential for normal development, reproduction, adenovirus infection, or the healing of cutaneous wounds...
  38. ncbi Type I gamma phosphatidylinositol phosphate kinase targets and regulates focal adhesions
    Kun Ling
    Department of Pharmacology, Program in Molecular and Cellular Pharmacology, University of Wisconsin Madison, 1300 University Avenue, University of Wisconsin Medical School, Madison, Wisconsin 53706, USA
    Nature 420:89-93. 2002
    ..This defines a mechanism for spatial generation of PtdIns(4,5)P(2) at focal adhesions...
  39. ncbi Focal adhesion kinase controls morphogenesis of the Drosophila optic stalk
    Satoshi Murakami
    Laboratory of Morphogenesis, Institute of Molecular and Cellular Biosciences, University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
    Development 134:1539-48. 2007
    ..Hence the optic stalk is a simple monolayered structure that can serve as an ideal system for studying glial cell morphogenesis and the developmental role(s) of focal adhesion signaling...
  40. ncbi The betaL integrin subunit is necessary for gastrulation in sea urchin embryos
    M Marsden
    Department of Biology, University of Victoria, Victoria, British Columbia, V8W 2Y2, Canada
    Dev Biol 203:134-48. 1998
    ..We propose that betaL forms receptors that bind to RGD-containing ligands and anchors actin filaments. These receptors appear to be essential in several aspects of morphogenesis...
  41. pmc Structural basis of the migfilin-filamin interaction and competition with integrin beta tails
    Yatish Lad
    Department of Pharmacology and Interdepartmental Program in Vascular Biology and Transplantation, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Biol Chem 283:35154-63. 2008
    ..In this specific case, displacement of integrin tails from filamin by migfilin may provide a mechanism for switching between different integrin-cytoskeleton linkages...
  42. ncbi A novel, tissue-specific integrin subunit, beta nu, expressed in the midgut of Drosophila melanogaster
    G H Yee
    Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge 02139
    Development 118:845-58. 1993
    ..Within this structure, beta v transcripts are especially concentrated in the cells of the midgut imaginal islands which give rise to the adult midgut...
  43. ncbi Roles for beta(pat-3) integrins in development and function of Caenorhabditis elegans muscles and gonads
    M Lee
    Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544-1014, USA
    J Biol Chem 276:36404-10. 2001
    ..These results show that betapat-3 plays important roles in post-embryonic organogenesis and tissue function...
  44. ncbi Role of alpha 4-integrins in lymphocyte homing to mucosal tissues in vivo
    A Hamann
    Department of Immunology, University Hospital of Eppendorf, Hamburg, Germany
    J Immunol 152:3282-93. 1994
    ..The results support a major, but not exclusive role of the alpha 4/beta 7-integrin in lymphocyte traffic to mucosal sites...
  45. pmc A family of beta 7 integrins on human mucosal lymphocytes
    C M Parker
    Laboratory of Immunochemistry, Dana Farber Cancer Institute, Boston, MA
    Proc Natl Acad Sci U S A 89:1924-8. 1992
    ....
  46. pmc Adenovirus vector vaccination induces expansion of memory CD4 T cells with a mucosal homing phenotype that are readily susceptible to HIV-1
    Adel Benlahrech
    Department of Immunology, Imperial College London, Chelsea and Westminster Hospital, 369 Fulham Road, London SW10 9NH, United Kingdom
    Proc Natl Acad Sci U S A 106:19940-5. 2009
    ....
  47. ncbi pat-4/ILK and unc-112/Mig-2 are required for gonad function in Caenorhabditis elegans
    Xiaojian Xu
    Department of Biology, Baylor University, One Bear Place 97388, Waco, TX 76798, USA
    Exp Cell Res 312:1475-83. 2006
    ..Taken together, our analysis confirms the role of integrin and integrin-associated proteins in gonad function...
  48. ncbi The beta 7 integrins in mucosal homing and retention
    S K Shaw
    Division of Rheumatology and Immunology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Semin Immunol 7:335-42. 1995
    ..Thus, members of the B7 subfamily of integrins, alpha E beta 7 and alpha 4 beta 7, and their counter-receptors, are believed to play key roles in directing lymphocyte traffic to and retention in mucosal organs...
  49. pmc Migfilin, a molecular switch in regulation of integrin activation
    Sujay Subbayya Ithychanda
    Department of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Biol Chem 284:4713-22. 2009
    ..Migfilin thus acts as a molecular switch to disconnect filamin from integrin for regulating integrin activation and dynamics of extracellular matrix-actin linkage...
  50. ncbi Lung epithelial lining fluid T cell subsets defined by distinct patterns of beta 7 and beta 1 integrin expression
    D J Erle
    Lung Biology Center, San Francisco General Hospital, California
    Am J Respir Cell Mol Biol 10:237-44. 1994
    ..The alpha E beta 7- and alpha E beta 7+ BALF T cell subsets were also found to differ in their expression of other integrins.(ABSTRACT TRUNCATED AT 250 WORDS)..
  51. ncbi Spatial heterogeneity of TNF-alpha-induced T cell migration to colonic mucosa is mediated by MAdCAM-1 and VCAM-1
    Chikako Watanabe
    Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan
    Am J Physiol Gastrointest Liver Physiol 283:G1379-87. 2002
    ..Spatial heterogeneity of MAdCAM-1 and VCAM-1 activation following TNF-alpha challenge may promote specific T lymphocyte recruitment in the inflamed colonic mucosa...
  52. pmc The Foxc2 transcription factor regulates angiogenesis via induction of integrin beta3 expression
    Hisaki Hayashi
    Division of Cardiovascular Medicine, Department of Medicine, Vanderbilt University Medical Center, 2220 Pierce Avenue, Nashville, TN 37232 6300, USA
    J Biol Chem 283:23791-800. 2008
    ..Taken together, these results suggest that Foxc2 directly induces Itgb3 expression and regulates angiogenesis by Itgb3-mediated endothelial cell adhesion and migration...
  53. pmc Chemokine signaling controls endodermal migration during zebrafish gastrulation
    Sreelaja Nair
    Department of Developmental and Cell Biology, University of California, Irvine, CA 92697, USA
    Science 322:89-92. 2008
    ..This process may have relevance to human gastrointestinal bifurcations and other organ defects...
  54. pmc Alpha4beta7/MAdCAM-1 interactions play an essential role in transitioning cryptopatches into isolated lymphoid follicles and a nonessential role in cryptopatch formation
    Caihong Wang
    Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    J Immunol 181:4052-61. 2008
    ....
  55. ncbi Simultaneous changes in the function and expression of beta 1 integrins during the growth arrest of poorly differentiated colorectal cells (LISP-1)
    R A Roela
    Disciplina de Oncologia, Departamento de Radiologia, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brasil
    Braz J Med Biol Res 36:1091-9. 2003
    ....
  56. ncbi Adhesion and migration of extracellular matrix-stimulated breast cancer
    John E Bartsch
    Department of Surgery, Medical College of Ohio, 3065 Arlington Avenue, Ohio 43614 5807, Toledo, USA
    J Surg Res 110:287-94. 2003
    ..We hypothesized that ECM binding to integrin receptors on breast cancer cells influenced cellular adhesion and migration...
  57. ncbi Advanced glycation endproducts interefere with integrin-mediated osteoblastic attachment to a type-I collagen matrix
    Antonio Desmond McCarthy
    Catedra de Bioquimica Patologica, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, 47 y 115, 1900 La Plata, Argentina
    Int J Biochem Cell Biol 36:840-8. 2004
    ..AGEs-modification of type-I collagen impairs the integrin-mediated adhesion of osteoblastic cells to the matrix, and could thus contribute to the pathogenesis of diabetic osteopenia...
  58. pmc Candida albicans expresses a focal adhesion kinase-like protein that undergoes increased tyrosine phosphorylation upon yeast cell adhesion to vitronectin and the EA.hy 926 human endothelial cell line
    Giorgio Santoni
    Department of Pharmacological Sciences and Experimental Medicine, University of Camerino, 62032 Camerino, Italy
    Infect Immun 70:3804-15. 2002
    ..hy 926 endothelial cells. Our results suggest that C. albicans Fak-like protein is involved in the control of yeast cell adhesion to VN and endothelial cells...
  59. ncbi A major lung CD103 (alphaE)-beta7 integrin-positive epithelial dendritic cell population expressing Langerin and tight junction proteins
    Sun Sang J Sung
    Department of Internal Medicine, University of Virginia School of Medicine, Charlotteville, 22908, USA
    J Immunol 176:2161-72. 2006
    ..They exhibit an activated phenotype in allergen-induced lung inflammation and may play significant roles in asthma pathogenesis...
  60. ncbi Bovine gamma delta T cell subsets express distinct patterns of chemokine responsiveness and adhesion molecules: a mechanism for tissue-specific gamma delta T cell subset accumulation
    Eric Wilson
    Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of Medicine, and Center for Molecular Biology and Medicine, Veterans Affairs Palo Alto Health Care System, CA 94304, USA
    J Immunol 169:4970-5. 2002
    ..These results suggest that the tropism of circulating CD8(+)gammadelta T cells for mucosal tissues is due, at least in part, to selective developmental expression of adhesion molecules and chemokine receptors...
  61. ncbi Cyclin-dependent kinase inhibitors block leukocyte adhesion and migration
    Li Liu
    Division of Hematology, Department of Medicine, University of Washington, Seattle, WA 98104, USA
    J Immunol 180:1808-17. 2008
    ..The finding that Cdk inhibitors can block leukocyte adhesion and migration may expand the clinical indications for this emerging class of therapeutics...
  62. ncbi Osteoclast size heterogeneity in rat long bones is associated with differences in adhesive ligand specificity
    Yingwei Hu
    Center for Oral Biology, Department of Odontology, Karolinska Institutet, SE 141 04 Huddinge, Sweden
    Exp Cell Res 314:638-50. 2008
    ..The small osteoclast adhering to PT and TH may represent either an immature, less functional precursor to the large osteoclast or alternatively constitute a distinct osteoclast population with a specific role in bone...
  63. ncbi Localization of extracellular matrix receptors on the chondrocyte primary cilium
    Susan R McGlashan
    Department of Anatomy with Radiology, Faculty of Medical and Health Sciences, University of Auckland, Private Bag 92019, Auckland, New Zealand
    J Histochem Cytochem 54:1005-14. 2006
    ..The data strongly suggest that chondrocyte primary cilia have the necessary machinery to act as mechanosensors, linking the ECM to cytoplasmic organelles responsible for matrix production and secretion...
  64. ncbi Neonatal infection with a milk-borne virus is independent of beta7 integrin- and L-selectin-expressing lymphocytes
    Jennifer Czarneski
    Department of Microbiology, University of Pennsylvania, Philadelphia, USA
    Eur J Immunol 32:945-56. 2002
    ..These results suggest that adhesion molecules other than beta7 integrin or L-selectin play a role in lymphocyte homing in the gut, peripheral lymph nodes and mammary gland in response to MMTV infection...
  65. ncbi Human gingival fibroblast integrin subunit expression on titanium implant surfaces
    Thomas W Oates
    Department of Periodontics, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229 3900, USA
    J Periodontol 76:1743-50. 2005
    ..Therefore, the aim of this study was to examine integrin expression for gingival fibroblasts on titanium surfaces and the influence of titanium surface roughness on integrin expression and cell morphology...
  66. ncbi Morphological analysis of integrin-mediated adhesion of immature human mast cells to extracellular matrix proteins
    Jens Küchler
    Department of Dermatology and Allergy, Charite, Humboldt University, Berlin, Germany
    Arch Dermatol Res 298:153-61. 2006
    ..This was associated with alignment of integrins along actin filaments within the cytoplasm, PKC signalling and changes in shape and activation of mast cells...
  67. ncbi The crystal structure of the plexin-semaphorin-integrin domain/hybrid domain/I-EGF1 segment from the human integrin beta2 subunit at 1.8-A resolution
    MinLong Shi
    School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551, Singapore
    J Biol Chem 280:30586-93. 2005
    ....
  68. ncbi The alpha4bbeta7-integrin is dynamically expressed on murine eosinophils and involved in eosinophil trafficking to the intestine
    E B Brandt
    Division of Allergy and Immunology, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    Clin Exp Allergy 36:543-53. 2006
    ..Most studies have focused on the role of the alpha4beta1-adhesion complex, but eosinophils also express the alpha4beta7-integrin complex...
  69. pmc Tetanus neurotoxin-mediated cleavage of cellubrevin impairs epithelial cell migration and integrin-dependent cell adhesion
    Veronique Proux-Gillardeaux
    Membrane Traffic in Neuronal and Epithelial Morphogenesis, Institut national de la santé et de la recherche médicale Avenir Team, Centre National de la Recherche Scientifique, Universités Paris 6 et 7, 75005 Paris, France
    Proc Natl Acad Sci U S A 102:6362-7. 2005
    ..These results suggest that Cb-dependent membrane trafficking participates in cell motility through the regulation of cell adhesion...
  70. ncbi Regulation of highly cytokinergic IgE-induced mast cell adhesion by Src, Syk, Tec, and protein kinase C family kinases
    Jiro Kitaura
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
    J Immunol 174:4495-504. 2005
    ..Thus, binding of HC IgEs to Fc epsilon RI induces adhesion of mast cells to fibronectin by modulating cellular activation signals in a unique fashion...
  71. pmc In vivo demonstration of T lymphocyte migration and amelioration of ileitis in intestinal mucosa of SAMP1/Yit mice by the inhibition of MAdCAM-1
    K Matsuzaki
    Second Department of Internal Medicine, National Defense Medical College, Saitama, Japan
    Clin Exp Immunol 140:22-31. 2005
    ..The results demonstrate that, although MAdCAM-1 and VCAM-1 play an important role in T lymphocyte-endothelial cell interactions in SAMP1/Yit mice, MAdCAM-1 may be a more appropriate target for therapeutic modulation of chronic ileitis...
  72. ncbi Integrin interactions with immobilized peptides in polyethylene glycol diacrylate hydrogels
    Anjelica L Gonzalez
    Section of Leukocyte Biology, Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA
    Tissue Eng 10:1775-86. 2004
    ..This model allows investigation of specific ligand-induced leukocyte functions and the development of engineered matrices with defined bioactive properties...
  73. pmc Bovine respiratory syncytial virus infection influences the impact of alpha- and beta-integrin-mediated adhesion of peripheral blood neutrophils
    E C Soethout
    Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands corrected
    Clin Exp Immunol 138:388-95. 2004
    ....
  74. ncbi Regulation of integrin functions by N-glycans
    Jianguo Gu
    Department of Biochemistry, Osaka University Graduate School of Medicine, B1, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Glycoconj J 21:9-15. 2004
    ..This review summarizes effects of the posttranslational modification of N-glycans of alpha3beta1 and alpha5beta1 integrins on their association, activation and biological functions, by using biochemical and genetic approaches...
  75. pmc Identification of integrin beta subunit mutations that alter heterodimer function in situ
    Alison L Jannuzi
    Department of Molecular and Cellular Biology, Arizona Cancer Center, University of Arizona, Tucson, Arizona 85724, USA
    Mol Biol Cell 15:3829-40. 2004
    ..Finally, comparisons with the sequence of human beta8 suggest that evolution has targeted the "mys(b58)" residue as a means of affecting integrin activity...
  76. ncbi CD98hc (SLC3A2) interaction with the integrin beta subunit cytoplasmic domain mediates adhesive signaling
    Gerald W Prager
    Department of Medicine, University of California San Diego, La Jolla, California 92093, USA
    J Biol Chem 282:24477-84. 2007
    ..These studies also provide new insights into how CD98hc may cooperate with other cytoplasmic domain binding proteins to modulate integrin functions and into the evolution of integrin signaling...
  77. ncbi Adhesion and signaling by B cell-derived exosomes: the role of integrins
    Aled Clayton
    Section of Clinical Oncology, Department of Medicine, University of Wales College of Medicine, Velindre Hospital, Whitchurch, Cardiff, UK
    FASEB J 18:977-9. 2004
    ....
  78. pmc Expression and function of C/EBP homology protein (GADD153) in podocytes
    Martin F Bek
    Department of Medicine, Division of Nephrology, University Clinics Muenster, Albert Schweitzer Str 33, 48149 Muenster, Germany
    Am J Pathol 168:20-32. 2006
    ..Our data suggest that CHOP-via increased ROS generation-regulates cell-matrix adhesion of podocytes in glomerular disease...
  79. ncbi Beta-integrin of Anopheles gambiae: mRNA cloning and analysis of structure and expression
    V Mahairaki
    Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas, 711 10 Heraklion, Crete, Greece
    Insect Mol Biol 10:217-23. 2001
    ..Finally, the expression of the gene does not seem to be modulated during blood meals, except for a substantial increase 48 h posthaematophagy, when digestion is nearly complete...
  80. pmc Mice lacking beta3 integrins are osteosclerotic because of dysfunctional osteoclasts
    K P McHugh
    Department of Pathology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Clin Invest 105:433-40. 2000
    ..Thus, although it is not required for osteoclastogenesis, the integrin alphavbeta3 is essential for normal osteoclast function...
  81. ncbi Maturation-dependent expression and function of the CD49d integrin on monocyte-derived human dendritic cells
    A Puig-Kroger
    Centro de Investigaciones Biologicas, Consejo Superior de Investigaciones Cientificas, Madrid, Spain Servicio de Inmuno Oncología, Hospital Universitario Gregorio Maranon, Madrid, Spain
    J Immunol 165:4338-45. 2000
    ..The differential expression of CD49d on immature and mature MDDC might contribute to their distinct motility capabilities and mediate mature DC migration into lymphoid organs...
  82. pmc Enhancement of endothelial cell migration and in vitro tube formation by TAP20, a novel beta 5 integrin-modulating, PKC theta-dependent protein
    S Tang
    Cardiovascular Division, Department of Medicine, Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Cell Biol 147:1073-84. 1999
    ..Thus, the discovery of TAP20, which interacts with integrin beta5 and modulates cell adhesion, migration, and tube formation, further defines a possible pathway to angiogenesis dependent on PKCtheta...
  83. ncbi Expression and cellular distribution of alpha(v)integrins in beta(1)integrin-deficient embryonic stem cell-derived cardiac cells
    K Guan
    In Vitro Differentiation Group, IPK Gatersleben, D-06466 Gatersleben, Germany
    J Mol Cell Cardiol 33:521-32. 2001
    ....
  84. ncbi Inflammatory cytokines synergize with the HIV-1 Tat protein to promote angiogenesis and Kaposi's sarcoma via induction of basic fibroblast growth factor and the alpha v beta 3 integrin
    G Barillari
    Laboratory of Virology, Istituto Superiore di Sanita, Rome, Italy
    J Immunol 163:1929-35. 1999
    ....
  85. ncbi Alpha9 and beta8 integrin expression correlates with the merger of the developing mouse eyelids
    M A Stepp
    Department of Anatomy and Cell Biology, Department of Ophthalmology, The George Washington University Medical Center, Washington, DC 20037, USA
    Dev Dyn 214:216-28. 1999
    ..The data presented identify specific integrins and matrix proteins that are likely to mediate eyelid fusion...
  86. ncbi Efficient lymphocyte migration across high endothelial venules of mouse Peyer's patches requires overlapping expression of L-selectin and beta7 integrin
    D A Steeber
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    J Immunol 161:6638-47. 1998
    ....
  87. ncbi The role of alpha and beta chains in ligand recognition by beta 7 integrins
    J M Higgins
    Lymphocyte Biology Section, Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Biol Chem 275:25652-64. 2000
    ..Thus, although specificity can be determined by the integrin alpha or beta chain, common structural features of both subunits are required for recognition of dissimilar ligands...
  88. pmc Intestinal mast cell progenitors require CD49dbeta7 (alpha4beta7 integrin) for tissue-specific homing
    M F Gurish
    Department of Medicine, Harvard Medical School, Boston, MA 02115, USA
    J Exp Med 194:1243-52. 2001
    ....
  89. ncbi Differential effects of the integrins alpha9beta1, alphavbeta3, and alphavbeta6 on cell proliferative responses to tenascin. Roles of the beta subunit extracellular and cytoplasmic domains
    Y Yokosaki
    Lung Biology Center, Center for Occupational and Environmental Health, Cardiovascular Research Institute, Department of Medicine, University of California, San Francisco, San Francisco, California 94143, USA
    J Biol Chem 271:24144-50. 1996
    ....
  90. ncbi Monoclonal antibodies specific for beta 7 integrin and mucosal addressin cell adhesion molecule-1 (MAdCAM-1) reduce inflammation in the colon of scid mice reconstituted with CD45RBhigh CD4+ T cells
    D Picarella
    LeukoSite, Inc, Cambridge, MA 02142, USA
    J Immunol 158:2099-106. 1997
    ....
  91. ncbi Recirculation and homing of lymphocyte subsets: dual homing specificity of beta 7-integrin(high)-lymphocytes in nonobese diabetic mice
    A Hänninen
    National Public Health Institute, Turku, Finland
    Blood 88:934-44. 1996
    ....
  92. ncbi The alphavbeta5 integrin functions as an endocytic receptor for vitronectin
    L M Memmo
    Cell and Molecular Biology Program, Albany Medical College, Albany, New York 12208, USA
    J Cell Sci 111:425-33. 1998
    ..This study provides the first evidence that the alphavbeta5 vitronectin receptor directly mediates the internalization of vitronectin...
  93. ncbi A point mutation in the integrin beta 6 subunit abolishes both alpha v beta 6 binding to fibronectin and receptor localization to focal contacts
    X Z Huang
    Lung Biology Center, UCSF 94143, USA
    Am J Respir Cell Mol Biol 13:245-51. 1995
    ....
  94. ncbi The roles of L-selectin, beta 7 integrins, and P-selectin in leukocyte rolling and adhesion in high endothelial venules of Peyer's patches
    E J Kunkel
    Department of Biomedical Engineering, University of Virginia School of Medicine, Charlottesville 22908, USA
    J Immunol 161:2449-56. 1998
    ..In situ, beta 7 integrins and L-selectin account for all lymphocyte homing to Peyer's patches, but P-selectin-dependent rolling, as induced by minimal trauma, may support trafficking of effector T lymphocytes to Peyer's patches...
  95. ncbi Molecular characterization of cell substratum attachments in human glial tumors relates to prognostic features
    N Belot
    Laboratory of Histopathology, Faculty of Medicine, Free University of Brussels, Brussels, Belgium
    Glia 36:375-90. 2001
    ..A potential role for the beta 8 integrin subunit in glioma cell substratum attachments is also emphasized...
  96. pmc The talin rod IBS2 alpha-helix interacts with the beta3 integrin cytoplasmic tail membrane-proximal helix by establishing charge complementary salt bridges
    Sophie Rodius
    Laboratoire de Biologie et Physiologie Intégrée CNRS GDRE ITI, Université du Luxembourg, L 1511 Luxembourg, Grand Duchy of Luxembourg
    J Biol Chem 283:24212-23. 2008
    ....
  97. ncbi Characterization of the human platelet glycoprotein IIIa gene. Comparison with the fibronectin receptor beta-subunit gene
    F Lanza
    COR Therapeutics, Inc, South San Francisco, California 94080
    J Biol Chem 265:18098-103. 1990
    ..Of the eight splice sites identified in beta 1, six occurred at the same amino acid residue in GPIIIa. These results provide genetic evidence that GPIIIa and beta 1 have a common evolutionary origin within the integrin family...
  98. pmc Pleomorphic adenoma and adenoid cystic carcinoma: in vitro study of the impact of TGFbeta1 on the expression of integrins and cytoskeleton markers of cell differentiation
    Silvia Vanessa Lourenço
    General Pathology Department, Dental School, University of Sao Paulo, Sao Paulo, Brazil
    Int J Exp Pathol 88:191-8. 2007
    ..ACC cells were less responsive to such stimulation. This may reflect important differences in the biological behaviour of benign and malignant cells...
  99. ncbi Cloning and sequence analysis of a novel beta 2-related integrin transcript from T lymphocytes: homology of integrin cysteine-rich repeats to domain III of laminin B chains
    Q A Yuan
    Department of Molecular Medicine, School of Medicine, University of Auckland, New Zealand
    Int Immunol 2:1097-108. 1990
    ..We conclude that beta 7 may be a new member of the leukocyte cell adhesion molecule subset of integrins, and is a candidate immunoregulatory molecule...
  100. ncbi The LIM-only protein DRAL/FHL2 binds to the cytoplasmic domain of several alpha and beta integrin chains and is recruited to adhesion complexes
    V Wixler
    Institute for Biochemistry II, Medical Faculty, University of Cologne, Joseph Stelzmann Strasse 52, 50931 Cologne, Germany
    J Biol Chem 275:33669-78. 2000
    ..These results, together with the fact that full-length DRAL/FHL2 is found in cell adhesion complexes, suggest that it is an adaptor/docking protein involved in integrin signaling pathways...
  101. ncbi Cloning and expression of a divergent integrin subunit beta 8
    M Moyle
    Department of Cardiovascular Research, Genentech, Inc, South San Francisco, California 94080
    J Biol Chem 266:19650-8. 1991
    ....

Research Grants39

  1. GENETIC ELEMENTS CONTROLLING MYELOID DIFFERENTIATION
    Edward Agura; Fiscal Year: 1993
    ..The CD18 gene, which codes for leukocyte integrin beta chains, is a target for myeloid transcriptional regulators; it is strongly induced by RA in HL60 cells and is ..
  2. CELLULAR TRAFFICKING TO INFLAMED FEMALE GENITAL MUCOSA
    Kathleen Kelly; Fiscal Year: 2007
    ..Insight into CXCL13 secretion will impact public health and the welfare of women in the US by aiding the development of therapeutics to prevent tubal infertility. ..
  3. Characterization of Corneal Epithelial Stem Cells
    Mary Ann Stepp; Fiscal Year: 2005
    ..Discovering specific molecular markers for the limbal stem cells will aid in the development of treatments for stem cell deficiency diseases of the ocular surface in humans. ..
  4. A NOVEL VECTOR FOR VACCINATION AGAINST HEPETITIS C VIRUS
    Nikolaus Osterrieder; Fiscal Year: 2006
    ..The tests will include ELISPOT and CTL assays in the context of a human class I allele using HLA-A2.1 transgenic mice. ..
  5. Novel Functions for Telomerase Enzyme Complex in Vivo
    Steven Artandi; Fiscal Year: 2005
    ..Through analysis of a conditional knockout mouse, we will determine the role of endogenous telomerase in cells in culture and in stern/progenitor compartments in vivo. ..
  6. Role of T Cell Immunity in Primate AIDS
    Aftab Ansari; Fiscal Year: 2006
    ....
  7. MOLECULAR MECHANISMS OF CD4+ T CELL DYSFUNCTION IN SIV
    Aftab Ansari; Fiscal Year: 2009
    ..abstract_text> ..
  8. P13Kdelta Modulation of Neutrophil Trafficking
    THOMAS DIACOVO; Fiscal Year: 2008
    ..Moreover, our results will define a new role for class I PBKs, regulation of the adhesive properties of inflamed endothelium. ..
  9. Development of a haspin kinase assay for high throughput drug screening
    JONATHAN HIGGINS; Fiscal Year: 2008
    ..Furthermore, such inhibitors will provide an excellent way to validate haspin as a target for cancer treatment, and they might find direct application as chemotherapeutic drugs. [unreadable] [unreadable] [unreadable]..
  10. Therapeutic DNA-MVA prime boost vaccination for HPV disease
    Cornelia Trimble; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  11. Pharmacology of Targeted Therapy to Brain Tumors
    FRANCIS SZOKA; Fiscal Year: 2008
    ..These results will provide a rationale for targeted therapies for human brain tumors. ..
  12. Role of Eotaxin-3/CCL26 in Allergic Asthma
    Lisa Miller; Fiscal Year: 2008
    ..The identification of chemokines that promote allergic asthma is an important step in the future development of therapeutics to target specific molecules within the airways. [unreadable] [unreadable] [unreadable]..
  13. VZV BACs: New Tools for Pathogenesis Research
    Nikolaus Osterrieder; Fiscal Year: 2005
    ..B-scid/beige mice, and infected MeWo or MeWo-9 cells will be used to inoculate the grafts. Virus replication in the implants will be examined by virus titrations, real-time PCR, histopathology and immunohistochemistry. ..
  14. CELL ADHESION MOLECULES OF MAMMALIAN FERTILIZATION
    Janice Evans; Fiscal Year: 2008
    ..This research also will also address fundamental questions in cell adhesion biology by examining this interesting, biologically relevant cell-cell interaction event. ..
  15. SJOGRENS SYNDROME SALIVARY GLAND AND APOPTOSIS
    Howard Dang; Fiscal Year: 2001
    ..Caspase inhibitors will be used to identify specific proteases during apoptosis. Biopsy material from patents with Sjogren's syndrome will be immunostained for bcl-2 family member expression. ..
  16. SYNTHETIC GENE CARRIERS TO TREAT CYSTIC FIBROSIS
    FRANCIS SZOKA; Fiscal Year: 2001
    ..abstract_text> ..
  17. Biocompatible Dendritic Polymers : In Vivo Applications
    FRANCIS SZOKA; Fiscal Year: 2002
    ..abstract_text> ..
  18. MHCL RESTRICTED TCR RECOGNITION--STRUCTURAL BASIS
    Jia huai Wang; Fiscal Year: 2002
    ..This should establish whether the docking mode is fixed or variable and whether there are restricted interactions between specific CDRs and MHC versus peptide residues. ..
  19. Adnesion Receptors of the Insect Immune System
    JAMES NARDI; Fiscal Year: 2003
    ..Understanding the molecular underpinnings of the insect immune response will clearly help in understanding the fate of pathogens in the blood of insect vectors of human diseases. ..
  20. SHEAR STRESS MODULATION OF ENDOTHELIAL WOUND HEALING
    MARIA LUIZA ALBUQUERQUE; Fiscal Year: 2003
    ..Investigation of the mechanisms underlying endothelial repair during shear stress may lead to better strategies for the management of patients suffering from a variety of cardiovascular disorders. ..
  21. Diabetes: Implant Integration, Success, and Benefit
    Thomas W Oates; Fiscal Year: 2010
    ..Ultimately, this information will contribute to the establishment of evidence-based guidelines for the assessment and application of dental implant therapy for patients with diabetes. ..
  22. Protein Interactions of the Germ Cell Kinase Haspin
    JONATHAN HIGGINS; Fiscal Year: 2004
    ..abstract_text> ..
  23. CD4 T Cell Activation in SIV+Disease Resistant Mangabeys
    Aftab Ansari; Fiscal Year: 2004
    ..abstract_text> ..
  24. A Phase I/II Trial of a Therapeutic HPV Vaccine
    Cornelia Trimble; Fiscal Year: 2004
    ....
  25. Neurotrophin Signaling in Multiple Myeloma
    Roger N Pearse; Fiscal Year: 2010
    ....
  26. Biocompatible Dendritic Polymers for in vivo Applications
    FRANCIS SZOKA; Fiscal Year: 2009
    ..Completion of this research will enable a variety of substantially improved targeted therapies and diagnostic imaging applications that can be successfully applied to treat humans with cancer. ..
  27. Early Immune Events in Childhood Asthma
    Lisa Miller; Fiscal Year: 2009
    ..abstract_text> ..
  28. Role of integrin signaling in gonad functions
    Myeongwoo Lee; Fiscal Year: 2007
    ..These studies will additionally advance our knowledge on the role of cell-ECM interaction in gonad development and functions. ..
  29. TAP20, NOVEL INTEGRIN MODULATING PROTEIN
    Shaoqing Tang; Fiscal Year: 2001
    ..We anticipate that these studies should provide data that will be useful in designing new strategic for pharmacologic intervention in ischemic vascular disease and cancer. ..
  30. HIV INFECTION/COCAINE EFFECT ON CARDIOVASCULAR PATHOLOGY
    Aftab Ansari; Fiscal Year: 2003
    ..We reason that such studies may provide unique insights on the relationship between the effects of cocaine and HIV infection in the pathogenesis of cardiovascular disease. ..
  31. TELOMERE DYSFUNCTION, GENOMIC INSTABILITY AND CANCER
    Steven Artandi; Fiscal Year: 2005
    ..Transplantation experiments using this model will reveal if the effect on tumor biology is a cell autonomous one. ..
  32. THERAPEUTIC VACCINES FOR HPV DISEASES
    Cornelia Trimble; Fiscal Year: 2005
    ..These facilities will be used to develop Dr. Trimble's ability to design and execute clinical trials evaluating preneoplastic HPV-associated lesions of the female lower genital tract. ..
  33. Motif-based elucidation of protein modification codes
    JONATHAN HIGGINS; Fiscal Year: 2006
    ..The development of methodology to determine the functional impact of these marks is therefore a critical requirement for future work in all areas of biomedicine. [unreadable] [unreadable]..
  34. Induction of hepatic tolerance to parasitic nematodes
    Susan Bliss; Fiscal Year: 2007
    ..The research emphasis of the Institute is directed towards animal models of disease, providing a highly supportive environment for the applicant's career development. ..
  35. Function of the chromosomal kinase haspin in mitosis
    JONATHAN M HIGGINS; Fiscal Year: 2010
    ..A greater knowledge of the role of human haspin in this process will help us understand the defects that underlie transformation and may lead to new approaches to block the division of cancer cells. ..
  36. Identification of Serum Markers of Liver Fibrogenesis/ Fibrolysis by Proteomics
    Detlef Schuppan; Fiscal Year: 2008
    ..Adaptation to the human proteome and prospective validation shall allow noninvasive monitoring of fibrosis progression and regression in patients with liver diseases. [unreadable] [unreadable] [unreadable]..
  37. Mouse Models for Celiac Disease
    Detlef Schuppan; Fiscal Year: 2007
    ..g. by immunomodulatory cytokines or by cytokine antagonists. It is anticipated that the results will improve our understanding and management of cd and related autoimmune diseases. ..
  38. Structure/Functional Characterization of vWF-A1 Domain
    THOMAS DIACOVO; Fiscal Year: 2007
    ..Information from these studies may aid in the design of antithrombotics with specific kinetic properties that can compete with the native-ligand pair. ..