integrin alpha chains

Summary

Summary: The alpha subunits of integrin heterodimers (INTEGRINS), which mediate ligand specificity. There are approximately 18 different alpha chains, exhibiting great sequence diversity; several chains are also spliced into alternative isoforms. They possess a long extracellular portion (1200 amino acids) containing a MIDAS (metal ion-dependent adhesion site) motif, and seven 60-amino acid tandem repeats, the last 4 of which form EF HAND MOTIFS. The intracellular portion is short (>50 AA) with the exception of INTEGRIN ALPHA4.

Top Publications

  1. ncbi Localization of alpha 7 integrins and dystrophin suggests potential for both lateral and longitudinal transmission of tension in large mammalian muscles
    Angelika C Paul
    Department of Anatomy and Structural Biology, University of Otago, Dunedin, New Zealand
    Cell Tissue Res 308:255-65. 2002
  2. pmc A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-beta and retinoic acid-dependent mechanism
    Janine L Coombes
    Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK
    J Exp Med 204:1757-64. 2007
  3. pmc Origin of the lamina propria dendritic cell network
    Milena Bogunovic
    Department of Gene and Cell Medicine, Mount Sinai School of Medicine, 1425 Madison Avenue, New York, NY 10029, USA
    Immunity 31:513-25. 2009
  4. pmc The origin and development of nonlymphoid tissue CD103+ DCs
    Florent Ginhoux
    Department of Gene and Cell Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Exp Med 206:3115-30. 2009
  5. pmc Interleukin 23 production by intestinal CD103(+)CD11b(+) dendritic cells in response to bacterial flagellin enhances mucosal innate immune defense
    Melissa A Kinnebrew
    Infectious Diseases Service, Department of Medicine, Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Immunity 36:276-87. 2012
  6. ncbi Intestinal lamina propria dendritic cell subsets have different origin and functions
    Chen Varol
    Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel 76100
    Immunity 31:502-12. 2009
  7. pmc Intestinal CD103+, but not CX3CR1+, antigen sampling cells migrate in lymph and serve classical dendritic cell functions
    Olga Schulz
    Institute of Immunology, Hannover Medical School, Hannover 30625, Germany
    J Exp Med 206:3101-14. 2009
  8. ncbi Skin-draining lymph nodes contain dermis-derived CD103(-) dendritic cells that constitutively produce retinoic acid and induce Foxp3(+) regulatory T cells
    Martin Guilliams
    Centre d immunologie de Marseille Luminy, Universite de la Mediterranee, Marseille, France
    Blood 115:1958-68. 2010
  9. ncbi Cross-presentation of viral and self antigens by skin-derived CD103+ dendritic cells
    Sammy Bedoui
    The Department of Microbiology and Immunology, The University of Melbourne, Parkville, Victoria, Australia
    Nat Immunol 10:488-95. 2009
  10. pmc Peripheral CD103+ dendritic cells form a unified subset developmentally related to CD8alpha+ conventional dendritic cells
    Brian T Edelson
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Exp Med 207:823-36. 2010

Detail Information

Publications229 found, 100 shown here

  1. ncbi Localization of alpha 7 integrins and dystrophin suggests potential for both lateral and longitudinal transmission of tension in large mammalian muscles
    Angelika C Paul
    Department of Anatomy and Structural Biology, University of Otago, Dunedin, New Zealand
    Cell Tissue Res 308:255-65. 2002
    ....
  2. pmc A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-beta and retinoic acid-dependent mechanism
    Janine L Coombes
    Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK
    J Exp Med 204:1757-64. 2007
    ..These results newly identify RA as a cofactor in T reg cell generation, providing a mechanism via which functionally specialized gut-associated lymphoid tissue DCs can extend the repertoire of T reg cells focused on the intestine...
  3. pmc Origin of the lamina propria dendritic cell network
    Milena Bogunovic
    Department of Gene and Cell Medicine, Mount Sinai School of Medicine, 1425 Madison Avenue, New York, NY 10029, USA
    Immunity 31:513-25. 2009
    ..Altogether, these results underline the diverse origin of the lamina propria DC network and identify mucosal DCs that arise from pre-DCs as key sentinels of the gut immune system...
  4. pmc The origin and development of nonlymphoid tissue CD103+ DCs
    Florent Ginhoux
    Department of Gene and Cell Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Exp Med 206:3115-30. 2009
    ..Our results reveal that nonlymphoid tissue CD103(+) DCs and lymphoid organ CD8(+) DCs derive from the same precursor and follow a related differentiation program...
  5. pmc Interleukin 23 production by intestinal CD103(+)CD11b(+) dendritic cells in response to bacterial flagellin enhances mucosal innate immune defense
    Melissa A Kinnebrew
    Infectious Diseases Service, Department of Medicine, Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Immunity 36:276-87. 2012
    ..Thus, CD103(+)CD11b(+) LPDCs, in addition to promoting long-term tolerance to ingested antigens, also rapidly produce IL-23 in response to detection of flagellin in the lamina propria...
  6. ncbi Intestinal lamina propria dendritic cell subsets have different origin and functions
    Chen Varol
    Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel 76100
    Immunity 31:502-12. 2009
    ..Our results highlight the critical importance of the lpDC subset balance for robust gut homeostasis...
  7. pmc Intestinal CD103+, but not CX3CR1+, antigen sampling cells migrate in lymph and serve classical dendritic cell functions
    Olga Schulz
    Institute of Immunology, Hannover Medical School, Hannover 30625, Germany
    J Exp Med 206:3101-14. 2009
    ....
  8. ncbi Skin-draining lymph nodes contain dermis-derived CD103(-) dendritic cells that constitutively produce retinoic acid and induce Foxp3(+) regulatory T cells
    Martin Guilliams
    Centre d immunologie de Marseille Luminy, Universite de la Mediterranee, Marseille, France
    Blood 115:1958-68. 2010
    ....
  9. ncbi Cross-presentation of viral and self antigens by skin-derived CD103+ dendritic cells
    Sammy Bedoui
    The Department of Microbiology and Immunology, The University of Melbourne, Parkville, Victoria, Australia
    Nat Immunol 10:488-95. 2009
    ..This indicates CD103(+) DCs are the main migratory subtype able to cross-present viral and self antigens, which identifies another level of specialization for skin DCs...
  10. pmc Peripheral CD103+ dendritic cells form a unified subset developmentally related to CD8alpha+ conventional dendritic cells
    Brian T Edelson
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Exp Med 207:823-36. 2010
    ..These data provide evidence for a developmental relationship between lymphoid organ-resident CD8alpha+ cDCs and nonlymphoid CD103+ DCs...
  11. pmc Small intestinal CD103+ dendritic cells display unique functional properties that are conserved between mice and humans
    Elin Jaensson
    Immunology Section, BMC D14, 221 84 Lund University, Lund, Sweden
    J Exp Med 205:2139-49. 2008
    ..Thus, small intestinal CD103(+) DCs represent a potential novel target for regulating human intestinal inflammatory responses...
  12. pmc Genomic definition of multiple ex vivo regulatory T cell subphenotypes
    Markus Feuerer
    Department of Pathology, Harvard Medical School, and Section on Immunology and Immunogenetics, Joslin Diabetes Center, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 107:5919-24. 2010
    ..Treg cells from the gut proved dissimilar to cells elicited by exposure to TGFbeta in vitro, but instead they resembled a CD103(+)Klrg1(+) subphenotype preferentially generated in response to lymphopenia...
  13. pmc CD207+ CD103+ dermal dendritic cells cross-present keratinocyte-derived antigens irrespective of the presence of Langerhans cells
    Sandrine Henri
    Centre d immunologie de Marseille Luminy, Universite de la Mediterranee, Case 906, 13288 Marseille Cedex 9, France
    J Exp Med 207:189-206. 2010
    ..Collectively, these data revisit the transfer of antigen that occurs between keratinocytes and the five distinguishable skin DC subsets and stress the high degree of functional specialization that exists among them...
  14. pmc Functional specialization of gut CD103+ dendritic cells in the regulation of tissue-selective T cell homing
    Bengt Johansson-Lindbom
    Immunology Section, Lund University, BMC I 13, 221 84 Lund, Sweden
    J Exp Med 202:1063-73. 2005
    ..Collectively, these results demonstrate a unique function for LP-derived CD103+ MLN DCs in the generation of gut-tropic effector T cells...
  15. ncbi IRF4 transcription-factor-dependent CD103(+)CD11b(+) dendritic cells drive mucosal T helper 17 cell differentiation
    Emma K Persson
    Immunology Section, Lund University, Lund 221 84, Sweden
    Immunity 38:958-69. 2013
    ..Together, our results suggest a central role for IRF4-dependent, IL-6 producing CD103(+)CD11b(+) DCs in intestinal Th17 cell differentiation...
  16. ncbi Development and functional specialization of CD103+ dendritic cells
    Maria Luisa del Rio
    Institute of Immunology, Hannover Medical School, Hannover, Germany
    Immunol Rev 234:268-81. 2010
    ..This review discusses recent findings that identify murine CD103(+) DCs as important regulators of the immune response...
  17. pmc Alveolar epithelial cells orchestrate DC function in murine viral pneumonia
    Barbara Unkel
    Department of Internal Medicine II, University of Giessen and Marburg Lung Center, Giessen, Germany
    J Clin Invest 122:3652-64. 2012
    ....
  18. ncbi Absence of integrin alpha 7 causes a novel form of muscular dystrophy
    U Mayer
    Max Planck Institute for Biochemistry, Martinsried, Germany
    Nat Genet 17:318-23. 1997
    ....
  19. ncbi Lung CD103+ dendritic cells efficiently transport influenza virus to the lymph node and load viral antigen onto MHC class I for presentation to CD8 T cells
    Adrian W S Ho
    Immunology Programme, Centre for Life Sciences, National University of Singapore, Singapore 117456
    J Immunol 187:6011-21. 2011
    ..Collectively, these results show that CD11b(low/neg)CD103(+) DCs are functionally specialized for the transport of Ag from the lung to the lymph node and also for efficient processing and presentation of viral Ags to CD8 T cells...
  20. ncbi Enteric flora expands gut lamina propria CX3CR1+ dendritic cells supporting inflammatory immune responses under normal and inflammatory conditions
    Jan Hendrik Niess
    Department of Internal Medicine I, Ulm University, Ulm, Germany
    J Immunol 184:2026-37. 2010
    ..The local bacteria-driven accumulation of CX(3)CR1(+) DCs seems to support inflammatory immune responses...
  21. pmc GM-CSF-dependent, CD103+ dermal dendritic cells play a critical role in Th effector cell differentiation after subcutaneous immunization
    Irah L King
    Interdepartmental Graduate Program in Neuroscience, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    J Exp Med 207:953-61. 2010
    ..The current report reveals a previously unidentified role for GM-CSF in DC ontogeny and identifies langerin(+)CD103(+) DCs as an important subset in CD4(+) T cell-mediated autoimmune disease...
  22. ncbi Intestinal inflammation abrogates the tolerogenic properties of MLN CD103+ dendritic cells
    Sophie Laffont
    Sir William Dunn School of Pathology, Oxford, UK
    Eur J Immunol 40:1877-83. 2010
    ....
  23. pmc Altering the distribution of Foxp3(+) regulatory T cells results in tissue-specific inflammatory disease
    Blythe D Sather
    Benaroya Research Institute, Seattle, WA 98101, USA
    J Exp Med 204:1335-47. 2007
    ..Thus, selectively altering T reg cell distribution in vivo leads to the development of tissue-specific inflammatory disease...
  24. ncbi Mucosal T lymphocyte numbers are selectively reduced in integrin alpha E (CD103)-deficient mice
    M P Schön
    Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 162:6641-9. 1999
    ..Integrin alpha E-deficient mice will provide an important tool for studying the role of alpha E beta 7 and of alpha E beta 7-expressing mucosal T lymphocytes in vivo...
  25. pmc Id2 expression delineates differential checkpoints in the genetic program of CD8α+ and CD103+ dendritic cell lineages
    Jacob T Jackson
    Molecular Immunology Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia
    EMBO J 30:2690-704. 2011
    ..Genetic mapping DC subset differentiation using Id2-GFP may have broad implications in understanding the interplay of DC subsets during protective and pathological immune responses...
  26. pmc CD8α(+) dendritic cells are an obligate cellular entry point for productive infection by Listeria monocytogenes
    Brian T Edelson
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    Immunity 35:236-48. 2011
    ..These results suggest that Batf3-dependent CD8α(+) and CD103(+) DCs provide initial cellular entry points within the reticuloendothelial system by which Listeria establishes productive infection...
  27. ncbi Characterization of four conventional dendritic cell subsets in human skin-draining lymph nodes in relation to T-cell activation
    Rieneke van de Ven
    Departments of Medical Oncology, VU University Medical Center Cancer Center Amsterdam, De Boelelaan, Amsterdam, The Netherlands
    Blood 118:2502-10. 2011
    ..These observations should be considered in the design of DC-targeting immunotherapies...
  28. ncbi CD4(+)CD25(+) immunoregulatory T cells: gene expression analysis reveals a functional role for the glucocorticoid-induced TNF receptor
    Rebecca S McHugh
    Cellular Immunology Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 16:311-23. 2002
    ..Importantly, antibodies to GITR abrogated suppression, demonstrating a functional role for this receptor in regulating the CD4(+)CD25(+) T cell subset...
  29. ncbi How vitamin A metabolizing dendritic cells are generated in the gut mucosa
    William W Agace
    Immunology Section, Lund University, Lund, Sweden
    Trends Immunol 33:42-8. 2012
    ..In this review, we discuss the environmental signals that appear to promote vitamin A metabolising activity in SI CD103(+) DCs in the steady state and thus which may contribute to driving the unique nature of SI immune responses...
  30. ncbi Key role for respiratory CD103(+) dendritic cells, IFN-γ, and IL-17 in protection against Streptococcus pneumoniae infection in response to α-galactosylceramide
    Stoyan Ivanov
    Institut Pasteur de Lille, Centre d Infection et d Immunité de Lille, France
    J Infect Dis 206:723-34. 2012
    ..We undertook the present study to characterize mechanisms leading to α-GalCer-mediated protection against lethal infection with Streptococcus pneumoniae serotype 1, a major respiratory pathogen in humans...
  31. pmc Self-renewal and expansion of single transplanted muscle stem cells
    Alessandra Sacco
    Baxter Laboratory in Genetic Pharmacology, Department of Microbiology and Immunology, Stem Cell Institute, Stanford University School of Medicine, Stanford, California 94305 5175, USA
    Nature 456:502-6. 2008
    ....
  32. ncbi CD103- and CD103+ bronchial lymph node dendritic cells are specialized in presenting and cross-presenting innocuous antigen to CD4+ and CD8+ T cells
    Maria Luisa del Rio
    Institute of Immunology, Hannover Medical School, Hannover, Germany
    J Immunol 178:6861-6. 2007
    ..Because these cells are largely absent in CCR7(-/-) mice, our findings strongly suggest that brLN CD103(+) DC are lung-derived and that expression of CCR7 is required for their migration from the lung into its draining lymph node...
  33. ncbi Increased airway T regulatory cells in asthmatic subjects
    Lucy J C Smyth
    University of Manchester, NIHR Translational Research Facility, Manchester Academic Health Science Centre, University Hospital of South Manchester Foundation Trust, Manchester, England
    Chest 138:905-12. 2010
    ..We also investigated the regulatory function of CD4 cells by expression of cytotoxic T-lymphocyte antigen 4 (CTLA4), and the number of these cells that are intraepithelial lymphocytes expressing CD103...
  34. pmc Priming microenvironments dictate cytokine requirements for T helper 17 cell lineage commitment
    Wei Hu
    Department of Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Immunity 35:1010-22. 2011
    ..These results reveal fundamental differences by which the systemic, mucosal, and cutaneous immune systems guide Th17 cell lineage commitment...
  35. pmc Bile retinoids imprint intestinal CD103+ dendritic cells with the ability to generate gut-tropic T cells
    E Jaensson-Gyllenbäck
    Department of Experimental Medical Sciences, Immunology Section, Lund University, Lund, Sweden
    Mucosal Immunol 4:438-47. 2011
    ..Taken together, these results suggest a novel and unexpected role for bile in SI-LP CD103(+) DC imprinting...
  36. pmc Pulmonary CD103(+) dendritic cells prime Th2 responses to inhaled allergens
    H Nakano
    Laboratory of Respiratory Biology, Division of Intramural Research, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, North Carolina, USA
    Mucosal Immunol 5:53-65. 2012
    ..Low-level antigen presentation by CD103(+) DCs was necessary, but not sufficient for Th2 priming. Together, these findings show that CD103(+) DCs have a significant role in priming Th2 responses to inhaled allergens...
  37. ncbi Mouse lung CD103+ and CD11bhigh dendritic cells preferentially induce distinct CD4+ T-cell responses
    Kazuki Furuhashi
    Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Am J Respir Cell Mol Biol 46:165-72. 2012
    ..These data suggest that mouse CD103(+) LDCs predominantly elicit Th1 and Th17 responses, whereas CD11b(high) LDCs primarily provoke a Th2 response under the steady state...
  38. ncbi Subsets of migrating intestinal dendritic cells
    Simon Milling
    Division of Immunology, Infection and Inflammation, Faculty of Medicine, University of Glasgow, Glasgow, UK
    Immunol Rev 234:259-67. 2010
    ..We believe that these studies will generate exciting data and have the potential to resolve important questions about the functions of migrating intestinal DC subsets...
  39. pmc Integrin alpha chains exhibit distinct temporal and spatial localization patterns in epithelial cells of the Drosophila ovary
    Michael B Dinkins
    Department of Cellular Biology, Medical College of Georgia, 1120 15th Street, CB1101, Augusta, GA 30912, USA
    Dev Dyn 237:3927-39. 2008
    ..Here, we analyze the expression of Drosophila integrin alpha chains in the ovarian follicular epithelium, a model for tissue morphogenesis and cell migration...
  40. ncbi Origin and development of dendritic cells
    Kang Liu
    Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10065, USA
    Immunol Rev 234:45-54. 2010
    ..Within tissues and during development, DC division and homeostasis are regulated by the hormone Flt3L...
  41. pmc Distribution and evolution of von Willebrand/integrin A domains: widely dispersed domains with roles in cell adhesion and elsewhere
    Charles A Whittaker
    Howard Hughes Medical Institute, Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Mol Biol Cell 13:3369-87. 2002
    ..These allow inferences about similar functions in novel situations such as protease regulators (e.g., complement factors and trypsin inhibitors) and intracellular proteins (e.g., helicases, chelatases, and copines)...
  42. ncbi Retinoic acid receptor signaling levels and antigen dose regulate gut homing receptor expression on CD8+ T cells
    M Svensson
    Section for Immunology, Lund University, Lund, Sweden
    Mucosal Immunol 1:38-48. 2008
    ..These results highlight a complex interplay between antigen dose and DC subset-induced RAR signaling events in the generation of tissue tropic effector T-cell subsets...
  43. ncbi Severe muscular dystrophy in mice that lack dystrophin and alpha7 integrin
    Jachinta E Rooney
    Department of Pharmacology, University of Nevada, Reno, 89557, USA
    J Cell Sci 119:2185-95. 2006
    ..These results point to complementary roles for dystrophin and alpha7beta1 integrin in maintaining the functional integrity of skeletal muscle...
  44. ncbi Regulation of CD103 expression by CD8+ T cells responding to renal allografts
    Donghua Wang
    Department of Surgery, University of Maryland Medical School, 10 South Pine Street, Baltimore, MD 21201, USA
    J Immunol 172:214-21. 2004
    ..These data support a model in which TGF-beta activity present locally at the graft site plays a critical role in regulating CD103 expression, and hence the epitheliotropism, of CD8 effector populations that infiltrate renal allografts...
  45. pmc Laminin-111 protein therapy prevents muscle disease in the mdx mouse model for Duchenne muscular dystrophy
    Jachinta E Rooney
    Department of Pharmacology, University of Nevada School of Medicine, Reno, NV 89557, USA
    Proc Natl Acad Sci U S A 106:7991-6. 2009
    ..These findings demonstrate that laminin-111 is a highly potent therapeutic agent for the mdx mouse model of DMD and represents a paradigm for the systemic delivery of extracellular matrix proteins as therapies for genetic diseases...
  46. ncbi Mutations in the integrin alpha7 gene cause congenital myopathy
    Y K Hayashi
    Department of Neuromuscular Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo, Japan
    Nat Genet 19:94-7. 1998
    ..A third showed marked deficiency of ITGA7 mRNA. Clinically, these patients showed congenital myopathy with delayed motor milestones. Our results demonstrate that mutations in ITGA7 are involved in a form of congenital myopathy...
  47. pmc Exercise promotes alpha7 integrin gene transcription and protection of skeletal muscle
    Marni D Boppart
    Department of Kinesiology and Community Health, University of Illinois, Urbana, Illinois, USA
    Am J Physiol Regul Integr Comp Physiol 295:R1623-30. 2008
    ..These combined molecular and cellular alterations are likely responsible for integrin-mediated attenuation of exercise-induced muscle damage...
  48. pmc Transgenic overexpression of the α7 integrin reduces muscle pathology and improves viability in the dy(W) mouse model of merosin-deficient congenital muscular dystrophy type 1A
    Jinger A Doe
    Department of Pharmacology, University of Nevada School of Medicine, Reno, NV 89557, USA
    J Cell Sci 124:2287-97. 2011
    ....
  49. pmc A CD8+/CD103high T cell subset regulates TNF-mediated chronic murine ileitis
    Johnson Ho
    Digestive Health Center of Excellence, University of Virginia Health Sciences Center, Charlottesville, VA 22908, USA
    J Immunol 180:2573-80. 2008
    ..These inflammation-driven populations exert distinct roles during the development of chronic ileitis, and influence the balance of effector and regulatory functions in the chronically inflamed small intestine...
  50. ncbi Novel subset of CD8{alpha}+ dendritic cells localized in the marginal zone is responsible for tolerance to cell-associated antigens
    Chun Hong Qiu
    RIKEN Research Center for Allergy and Immunology, Kanagawa, Japan
    J Immunol 182:4127-36. 2009
    ..Transient ablation of this DC subset by cytochrome c injection resulted in a failure of tolerance induction to cell-associated Ags, indicating that this DC subset is essential for tolerance induction by apoptotic cell clearance...
  51. ncbi The diverse ontogeny and function of murine small intestinal dendritic cell/macrophage subsets
    Emma K Persson
    Immunology Section, Lund University, Lund, Sweden
    Immunobiology 215:692-7. 2010
    ..These latter observations suggest an important division of labour between dendritic cell/macrophage subsets in the regulation of intestinal immune responses in the steady state...
  52. ncbi Intratumoral induction of CD103 triggers tumor-specific CTL function and CCR5-dependent T-cell retention
    Katarzyna Franciszkiewicz
    Institut National de la Santé et de la Recherche Médicale U753, Laboratoire Immunologie des Tumeurs Humaines, Interaction Effecteurs Cytotoxiques Système Tumoral, Institut Fédératif de Recherche 54, Villejuif, France
    Cancer Res 69:6249-55. 2009
    ..They also suggest a unique role of CD103 in T-cell retention at the tumor site by a CCR5-dependent mechanism...
  53. pmc The cytoplasmic domain of the integrin alpha9 subunit requires the adaptor protein paxillin to inhibit cell spreading but promotes cell migration in a paxillin-independent manner
    B A Young
    Lung Biology Center, Department of Medicine, University of California, San Francisco, 94110, USA
    Mol Biol Cell 12:3214-25. 2001
    ....
  54. ncbi Alloantigen-induced regulatory CD8+CD103+ T cells
    Sven D Koch
    Department of Experimental Immunology, Academic Medical Center, Meibergdreef 9, P O Box 22660, 1100 DD Amsterdam, The Netherlands
    Hum Immunol 69:737-44. 2008
    ..Through intracellular cytokine staining and transwell assays, we showed that the mechanism of suppression is cytokine independent, but close cell-cell contact is required for suppression...
  55. ncbi A major lung CD103 (alphaE)-beta7 integrin-positive epithelial dendritic cell population expressing Langerin and tight junction proteins
    Sun Sang J Sung
    Department of Internal Medicine, University of Virginia School of Medicine, Charlotteville, 22908, USA
    J Immunol 176:2161-72. 2006
    ..They exhibit an activated phenotype in allergen-induced lung inflammation and may play significant roles in asthma pathogenesis...
  56. ncbi Human intestinal epithelial cells promote the differentiation of tolerogenic dendritic cells
    I D Iliev
    Department of Experimental Oncology, European Institute of Oncology, 20141 Milan, Italy
    Gut 58:1481-9. 2009
    ..In this study, an analysis was carried out to determine whether IECs could promote the differentiation of CD103+ tolerogenic DCs, and the function of primary CD103+ DCs isolated from human mesenteric lymph nodes (MLNs) was evaluated...
  57. ncbi Role for the alpha7beta1 integrin in vascular development and integrity
    Nichole L Flintoff-Dye
    Department of Pharmacology, University of Nevada, Manville Health Science Building, Reno, 89557, USA
    Dev Dyn 234:11-21. 2005
    ....
  58. pmc Failure to recruit anti-inflammatory CD103+ dendritic cells and a diminished CD4+ Foxp3+ regulatory T cell pool in mice that display excessive lung inflammation and increased susceptibility to Mycobacterium tuberculosis
    Chaniya Leepiyasakulchai
    Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden
    Infect Immun 80:1128-39. 2012
    ..Our results show that αE-DCs and T(reg) cells that may regulate the host immune response are increased in M. tuberculosis-infected lungs of resistant mice but diminished in infected lungs of susceptible mice...
  59. ncbi Alpha8 integrin in glomerular mesangial cells and in experimental glomerulonephritis
    A Hartner
    Medizinische Klinik IV, Universitat Erlangen Nurnberg, Erlangen, Germany
    Kidney Int 56:1468-80. 1999
    ..In addition, the regulation of alpha8 expression in MCs was studied in culture and in nephritic rats...
  60. ncbi The acquisition of antigen cross-presentation function by newly formed dendritic cells
    Priyanka Sathe
    Walter and Eliza Hall Institute, Parkville, Victoria 3052, Australia
    J Immunol 186:5184-92. 2011
    ..These results explain the considerable variability in CD103 expression by CD8(+) DCs as well as the findings that not all DCs of this lineage are capable of cross-presentation...
  61. ncbi Density of CD163+ CD11c+ dendritic cells increases and CD103+ dendritic cells decreases in the coeliac lesion
    A C R Beitnes
    Centre for Immune Regulation, Institute of Immunology, Oslo University Hospital, Rikshospitalet, Oslo, Norway
    Scand J Immunol 74:186-94. 2011
    ....
  62. pmc Respiratory dendritic cell subsets differ in their capacity to support the induction of virus-specific cytotoxic CD8+ T cell responses
    Taeg S Kim
    Beirne B Carter Center for Immunology Research, University of Virginia, Charlottesville, Virginia, United States of America
    PLoS ONE 4:e4204. 2009
    ..These results identify CD103(+) and CD11b(hi) RDC as critical regulators of the adaptive immune response to respiratory tract infection and potential targets in the design of mucosal vaccines...
  63. pmc Reduction of mouse egg surface integrin alpha9 subunit (ITGA9) reduces the egg's ability to support sperm-egg binding and fusion
    Ulyana Vjugina
    Department of Biochemistry and Molecular Biology, Division of Reproductive Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21205, USA
    Biol Reprod 80:833-41. 2009
    ..This also shows that careful design of IVF parameters allows detection of deficiencies in gamete interactions...
  64. ncbi Laminins promote the locomotion of skeletal myoblasts via the alpha 7 integrin receptor
    C C Yao
    Department of Stomatology, School of Dentistry, University of California San Francisco 94143 0512, USA
    J Cell Sci 109:3139-50. 1996
    ..These results established that alpha 7 beta 1 receptor can promote myoblast adhesion and motility on a restricted number of laminin isoforms and may be important in myogenic precursor recruitment during regeneration and differentiation...
  65. ncbi Integrin alpha E(CD103)beta 7 mediates adhesion to intestinal microvascular endothelial cell lines via an E-cadherin-independent interaction
    U G Strauch
    The Lymphocyte Biology Section, Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Boston, MA 02115, USA
    J Immunol 166:3506-14. 2001
    ..These studies suggest a role for alpha(E)beta(7) in interactions with the intestinal endothelium that may have implications for intestinal T cell homing or functional responses...
  66. pmc Genetically determined proteolytic cleavage modulates alpha7beta1 integrin function
    Jianming Liu
    Department of Cell and Developmental Biology, University of Illinois, Urbana, Illinois 61801, USA
    J Biol Chem 283:35668-78. 2008
    ....
  67. ncbi The epithelial cell-specific integrin, CD103 (alpha E integrin), defines a novel subset of alloreactive CD8+ CTL
    G A Hadley
    Department of Surgery, University of Maryland Medical School, Baltimore 21201, USA
    J Immunol 159:3748-56. 1997
    ..The potential for CD103+ CTL as an important effector mechanism in organ allograft rejection, and more generally, as a mechanistic basis for tissue-specific immune phenomena, is discussed...
  68. pmc Directed antigen targeting in vivo identifies a role for CD103+ dendritic cells in both tolerogenic and immunogenic T-cell responses
    M Semmrich
    Immunology Section, Lund University, Lund, Sweden
    Mucosal Immunol 5:150-60. 2012
    ..These findings identify antigen targeting to CD103(+) DCs as a potential strategy to regulate immune responses in nonlymphoid mucosal tissues...
  69. ncbi Tiggrin, a novel Drosophila extracellular matrix protein that functions as a ligand for Drosophila alpha PS2 beta PS integrins
    F J Fogerty
    Department of Biology, University of California, Los Angeles 90024 1606
    Development 120:1747-58. 1994
    ..Tiggrin-coated surfaces support primary embryo cell culture and provide excellent substrates for alpha PS2 beta PS integrin-mediated cell spreading. Soluble RGD-peptides inhibit this cell spreading...
  70. ncbi Analysis of the roles of RGD-binding integrins, alpha(4)/alpha(9) integrins, alpha(6) integrins, and CD9 in the interaction of the fertilin beta (ADAM2) disintegrin domain with the mouse egg membrane
    Xiaoling Zhu
    Department of Biochemistry and Molecular Biology, Division of Reproductive Biology, Bloomberg School of Public Health, Johns Hopkins University, 615 N Wolfe Street, Baltimore, MD 21205, USA
    Biol Reprod 66:1193-202. 2002
    ....
  71. ncbi Collagen-binding I domain integrins--what do they do?
    Donald E Gullberg
    Department of Medical Biochemistry and Microbiology, Biomedical Center, Box 582, Uppsala University, S 75123 Uppsala, Sweden
    Prog Histochem Cytochem 37:3-54. 2002
    ..In this review we will describe what is currently known about the collagen-binding integrins and discuss their biological functions...
  72. ncbi Tubulitis after renal transplantation: demonstration of an association between CD103+ T cells, transforming growth factor beta1 expression and rejection grade
    H Robertson
    Department of Surgery, Medical School, University of Newcastle, Newcastle upon Tyne, UK
    Transplantation 71:306-13. 2001
    ..The capacity of CD103+ T cells to bind E-cadherin on tubular epithelial cells may be an important factor in the pathogenesis of specific tissue damage observed in acute renal allograft rejection...
  73. pmc Essential role for CD103 in the T cell-mediated regulation of experimental colitis
    Oliver Annacker
    Sir William Dunn School of Pathology, University of Oxford, OX1 3RE, England, UK
    J Exp Med 202:1051-61. 2005
    ..Collectively, these data suggest that CD103+ and CD103- DCs represent functionally distinct subsets and that CD103 expression on DCs influences the balance between effector and regulatory T cell activity in the intestine...
  74. ncbi Alpha10 integrin expression is up-regulated on fibroblast growth factor-2-treated mesenchymal stem cells with improved chondrogenic differentiation potential
    Laura Varas
    Cartela AB, 220 07 Lund, Sweden
    Stem Cells Dev 16:965-78. 2007
    ..We show that MSCs with high chondrogenic differentiation potential are highly alpha10 positive and propose alpha10 as a potential marker to predict the differentiation state of MSCs...
  75. pmc Sequence and tissue distribution of the integrin alpha 9 subunit, a novel partner of beta 1 that is widely distributed in epithelia and muscle
    E L Palmer
    Lung Biology Center, University of California, San Francisco 94143
    J Cell Biol 123:1289-97. 1993
    ..alpha 9 was detected by immunohistochemistry in airway epithelium, in the basal layer of squamous epithelium, and in smooth muscle, skeletal muscle, and hepatocytes...
  76. ncbi Characterization of the mouse integrin subunit alpha10 gene and comparison with its human homologue. Genomic structure, chromosomal localization and identification of splice variants
    T Bengtsson
    Department of Experimental Pathology, Lund University Hospital, SE 221 85 Lund, Sweden
    Matrix Biol 20:565-76. 2001
    ..In mouse, exon 26 was extended into the intron by 62 nt, generating a truncated alpha10-chain. In human, exon 25 consisted of 114 nt which were alternately spliced in or out...
  77. ncbi A novel leukointegrin, alpha d beta 2, binds preferentially to ICAM-3
    M Van der Vieren
    ICOS Corporation, Bothell, Washington 98021, USA
    Immunity 3:683-90. 1995
    ..The alpha d/CD18 molecule exhibits preferential recognition of ICAM-3 over ICAM-1...
  78. ncbi Expression of alpha 7 integrin cytoplasmic domains during skeletal muscle development: alternate forms, conformational change, and homologies with serine/threonine kinases and tyrosine phosphatases
    W K Song
    Department of Cell and Structural Biology, University of Illinois, Urbana 61801
    J Cell Sci 106:1139-52. 1993
    ..Crosslinking also promotes association of the integrin with the cell cytoskeleton.(ABSTRACT TRUNCATED AT 400 WORDS)..
  79. ncbi A new subset of CD103+CD8alpha+ dendritic cells in the small intestine expresses TLR3, TLR7, and TLR9 and induces Th1 response and CTL activity
    Kosuke Fujimoto
    Laboratory of Host Defense, World Premier International Immunology Frontier Research Center, Osaka University, Osaka 565 0871, Japan
    J Immunol 186:6287-95. 2011
    ..Accordingly, CD103(+)CD8α(+) LPDCs exhibit a different function from CD103(+)CD8α(-) LPDCs in active immunity. This is the first analysis, to our knowledge, of CD8α(+) DCs in the LP of the small intestine...
  80. pmc E-cadherin marks a subset of inflammatory dendritic cells that promote T cell-mediated colitis
    Karima R R Siddiqui
    Sir William Dunn School of Pathology, University of Oxford, OX1 3RE Oxford, UK
    Immunity 32:557-67. 2010
    ..These results identify a monocyte-derived inflammatory DC subset that is associated with the pathogenesis of intestinal inflammation, providing a therapeutic target for the treatment of inflammatory bowel disease...
  81. ncbi CD103 is a hallmark of tumor-infiltrating regulatory T cells
    David Anz
    Center of Integrated Protein Science Munich, Division of Clinical Pharmacology, Ziemssenstrasse 1, 80336 Munich, Germany
    Int J Cancer 129:2417-26. 2011
    ..CD103 thus represents an interesting target for selective depletion of tumor-infiltrating Treg, a strategy that may help to improve anti-cancer therapy...
  82. ncbi Regulation of the epithelial cell-specific integrin, CD103, by human CD8+ cytolytic T lymphocytes
    G A Hadley
    Department of Surgery, University of Maryland Medical School, Baltimore 21201, USA
    Transplantation 67:1418-25. 1999
    ..The goal of the present study was to assess the relevance of these data to the human system...
  83. ncbi PS2 integrin requirements in Drosophila embryo and wing morphogenesis
    M C Brabant
    Department of Biochemistry, University of Arizona, Tucson 85721
    Dev Biol 157:49-59. 1993
    ..By varying times of transgene induction, we find that integrin function is required from very early in metamorphosis until at least the last 24-48 hr of wing development...
  84. ncbi Denervation dynamically regulates integrin alpha7 signaling pathways and microscopic structures in rats
    Feng Chou Tsai
    Center for Mathematical Biology, Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, and Department of Surgery, Taipei Medical University Hospital, Taipei, Taiwan
    J Trauma 70:220-7. 2011
    ..Expression profiles of integrin alpha7 signaling pathways and the molecule's microscopic structure were assessed to investigate the long-term dynamic changes in denervated rat skeletal muscle...
  85. ncbi Differential effects of the integrins alpha9beta1, alphavbeta3, and alphavbeta6 on cell proliferative responses to tenascin. Roles of the beta subunit extracellular and cytoplasmic domains
    Y Yokosaki
    Lung Biology Center, Center for Occupational and Environmental Health, Cardiovascular Research Institute, Department of Medicine, University of California, San Francisco, San Francisco, California 94143, USA
    J Biol Chem 271:24144-50. 1996
    ....
  86. ncbi Cloning and characterization of alpha PS1, a novel Drosophila melanogaster integrin
    M Wehrli
    MRC Laboratory of Molecular Biology, Cambridge, UK
    Mech Dev 43:21-36. 1993
    ..elegans F54G8.3 integrins. We find several positions and phases of introns conserved which, supported by conservation also in the amino acid sequence, indicates that they all derive from a common ancestral gene...
  87. pmc Optimization of methods to study pulmonary dendritic cell migration reveals distinct capacities of DC subsets to acquire soluble versus particulate antigen
    Claudia Jakubzick
    Department of Gene and Cell Medicine, Icahn Research Institute, Mount Sinai School of Medicine, NY, New York 10029, United States
    J Immunol Methods 337:121-31. 2008
    ..This finding suggests that changes in the physical presentation of the same antigen delivered to the airway during natural immune responses or vaccinations may markedly affect the character of the T cell response that ensues...
  88. pmc The integrin alpha9beta1 mediates adhesion to activated endothelial cells and transendothelial neutrophil migration through interaction with vascular cell adhesion molecule-1
    Y Taooka
    Lung Biology Center, Center for Occupational and Environmental Health, Cardiovascular Research Institute and the Department of Medicine, University of California, San Francisco, California 94143, USA
    J Cell Biol 145:413-20. 1999
    ..These observations suggest a possible role for alpha9beta1/VCAM-1 interactions in extravasation of neutrophils at sites of acute inflammation...
  89. pmc Laminin-111 restores regenerative capacity in a mouse model for alpha7 integrin congenital myopathy
    Jachinta E Rooney
    Department of Pharmacology, University of Nevada School of Medicine, Reno, Nevada 89557, USA
    Am J Pathol 174:256-64. 2009
    ..Our data demonstrate a critical role for a laminin-rich microenvironment in muscle repair and suggest laminin- 111 protein may serve as an unexpected and novel therapeutic agent for patients with congenital myopathies...
  90. ncbi Tubulitis in renal allograft rejection: role of transforming growth factor-beta and interleukin-15 in development and maintenance of CD103+ intraepithelial T cells
    Wai Keong Wong
    Applied Immunobiology Group, Department of Surgery, Medical School, University of Newcastle upon Tyne NE2 4HH, UK
    Transplantation 75:505-14. 2003
    ..We investigated the development and maintenance of allospecific CD103 T cells within the tubular microenvironment...
  91. ncbi Laminin alpha1 chain mediated reduction of laminin alpha2 chain deficient muscular dystrophy involves integrin alpha7beta1 and dystroglycan
    Kinga I Gawlik
    Department of Experimental Medical Science, Division for Cell and Matrix Biology, University of Lund, BMC B12 221 84 Lund, Sweden
    FEBS Lett 580:1759-65. 2006
    ..We suggest that LNalpha1 chain in part ameliorates the development of LNalpha2 chain deficient muscular dystrophy by retaining the binding sites for integrin alpha7Bbeta1D and alpha-dystroglycan, respectively...
  92. ncbi Defects in keratinocyte activation during wound healing in the syndecan-1-deficient mouse
    Mary Ann Stepp
    Department of Anatomy and Cell Biology, The George Washington University Medical School, Washington DC 20037, USA
    J Cell Sci 115:4517-31. 2002
    ....
  93. ncbi Transforming growth factor-beta 1-induced expression of the mucosa-related integrin alpha E on lymphocytes is not associated with mucosa-specific homing
    F Austrup
    Abteilung fur Immunologie, Universitatskrankenhaus Eppendorf, Hamburg, Germany
    Eur J Immunol 25:1487-91. 1995
    ..The results indicate that alpha E beta 7 does not act as a homing receptor, and that the expression of the site-specific marker alpha E does not correlate with a distinct homing behavior...
  94. pmc Role of the mucosal integrin alpha(E)(CD103)beta(7) in tissue-restricted cytotoxicity
    L J C Smyth
    Institute of Pharmacy, Chemistry and Biomedical Sciences, University of Sunderland, UK
    Clin Exp Immunol 149:162-70. 2007
    ..CD103 functions to conjugate CTL effectors to e-cadherin-expressing targets and thereby facilitates cellular cytotoxicity. E-cadherin is expressed prominently by epithelial cells in the lung, enabling CTL to target them for destruction...
  95. pmc An anti-CD103 immunotoxin promotes long-term survival of pancreatic islet allografts
    L Zhang
    Division of Transplantation, Department of Surgery, The Ohio State University Medical Center, Columbus, OH, USA
    Am J Transplant 9:2012-23. 2009
    ..Regardless of the underlying mechanisms, these data document that depletion of CD103-expressing cells represents a viable strategy for therapeutic intervention in allograft rejection...
  96. ncbi Zebrafish integrin-linked kinase is required in skeletal muscles for strengthening the integrin-ECM adhesion complex
    Ruben Postel
    Hubrecht Institute and University Medical Centre Utrecht, The Netherlands
    Dev Biol 318:92-101. 2008
    ....
  97. pmc A virus-encoded telomerase RNA promotes malignant T cell lymphomagenesis
    Sascha Trapp
    Department of Microbiology and Immunology, Cornell University, Ithaca, NY 14853, USA
    J Exp Med 203:1307-17. 2006
    ..We concluded that vTR plays a critical role in MDV-induced T cell lymphomagenesis. Furthermore, our results provide the first description of tumor-promoting effects of TR in a natural virus-host infection model...
  98. ncbi alpha 8 Integrin overexpression in de-differentiated vascular smooth muscle cells attenuates migratory activity and restores the characteristics of the differentiated phenotype
    Ramin Zargham
    Institut de Recherches Cliniques de Montreal, Universite de Montreal, Montreal, Quebec, Canada
    Atherosclerosis 195:303-12. 2007
    ..Our findings suggest a dynamic role for alpha 8 beta 1 integrin to induce contractile phenotype as well as suppression of VSMC migration, a key player during arterial stenosis...
  99. ncbi Osteopontin N-terminal domain contains a cryptic adhesive sequence recognized by alpha9beta1 integrin
    L L Smith
    Department of Pathology, University of Washington, Seattle, Washington 98195, USA
    J Biol Chem 271:28485-91. 1996
    ..We also demonstrate that osteopontin contains a cryptic binding activity, which can be recognized by a novel osteopontin receptor. This receptor has been identified as the alpha9beta1 integrin...
  100. ncbi Diverse and potent chemokine production by lung CD11bhigh dendritic cells in homeostasis and in allergic lung inflammation
    Steven R Beaty
    Department of Internal Medicine, University of Virginia Health Sciences Center, Charlottesville, VA 22908, USA
    J Immunol 178:1882-95. 2007
    ..These studies showed that lung CD11b(high) DC is one of the most important leukocyte types in chemokine production and it is readily distinguishable from CD103(+) DC in this secretory function...
  101. ncbi Expression of the integrin subunit alpha 9 in the murine embryo
    A Wang
    Lung Biology Center, San Francisco General Hospital, University of California 94143, USA
    Dev Dyn 204:421-31. 1995
    ..The expression of alpha 9 without its only known ligand, tenascin, suggests the existence of additional ligands...

Research Grants25

  1. Beta 1 Integrins and Cellular Responses to TGFbeta
    Kevin Kim; Fiscal Year: 2005
    ..2) We will alter gene expression of several integrin alpha chains known to associate with beta1 by RNA interference to determine if a specific alpha-beta1 heterodimer is ..
  2. Characterization of Corneal Epithelial Stem Cells
    Mary Ann Stepp; Fiscal Year: 2005
    ..Discovering specific molecular markers for the limbal stem cells will aid in the development of treatments for stem cell deficiency diseases of the ocular surface in humans. ..
  3. Molecular Mechanisms That Regulate CD11d Expression
    JOHN NOTI; Fiscal Year: 2004
    ..Transgenic analysis of the CD11d cis elements will be done to complement these studies. These studies will expand our understanding of normal myeloid development and leukemogenesis. ..
  4. A NOVEL VECTOR FOR VACCINATION AGAINST HEPETITIS C VIRUS
    Nikolaus Osterrieder; Fiscal Year: 2006
    ..The tests will include ELISPOT and CTL assays in the context of a human class I allele using HLA-A2.1 transgenic mice. ..
  5. Novel Functions for Telomerase Enzyme Complex in Vivo
    Steven Artandi; Fiscal Year: 2005
    ..Through analysis of a conditional knockout mouse, we will determine the role of endogenous telomerase in cells in culture and in stern/progenitor compartments in vivo. ..
  6. Long Term Effects of Influenza Virus on T Cell Migration
    LINDA CAULEY; Fiscal Year: 2007
    ..These mice will be used to determine whether T cell activation in the lungs is prevented when antigen-bearing APCs are depleted in vivo. [unreadable] [unreadable] [unreadable]..
  7. Development of a haspin kinase assay for high throughput drug screening
    JONATHAN HIGGINS; Fiscal Year: 2008
    ..Furthermore, such inhibitors will provide an excellent way to validate haspin as a target for cancer treatment, and they might find direct application as chemotherapeutic drugs. [unreadable] [unreadable] [unreadable]..
  8. Deciphering the Relevance and Etiology of Th2 Cytokine Skewing in WASP KO Mice
    Deanna Nguyen; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  9. Neurotrophin Signaling in Multiple Myeloma
    Roger N Pearse; Fiscal Year: 2010
    ....
  10. Structure/Function Studies of the Integrin
    Thomas A Bunch; Fiscal Year: 2010
    ..We will pursue experiments that will address this hypothesis, potentially redefining the role of talin in integrin regulation. ..
  11. Diabetes: Implant Integration, Success, and Benefit
    Thomas W Oates; Fiscal Year: 2010
    ..Ultimately, this information will contribute to the establishment of evidence-based guidelines for the assessment and application of dental implant therapy for patients with diabetes. ..
  12. REGULATION OF MYOTENDINOUS JUNCTION STRUCTURE
    James Tidball; Fiscal Year: 2001
    ..Hind limb immobilization at shortened length followed by remobilization will be used to examine the effect of inhibition of NOS on sarcomere addition. ..
  13. Myeloid Cell Function in Muscular Dystrophy
    James Tidball; Fiscal Year: 2005
    ..Results of the study proposed here will permit us to determine whether therapeutic approaches that are based on reducing myeloid cell mediated pathology can be productive approaches to the treatment of these forms of muscular dystrophy. ..
  14. POSTDOCTORAL HEMATOLOGY RESEARCH TRAINING
    George Dale; Fiscal Year: 2003
    ..Francis Fdt. (OUHSC). All members of the faculty work closely together under Specialized Center of Research (SCOR) and Program Project (PP)...
  15. Protein Interactions of the Germ Cell Kinase Haspin
    JONATHAN HIGGINS; Fiscal Year: 2004
    ..abstract_text> ..
  16. Common Mediators of Vascular Calcification and Bone Dis*
    Cecilia Giachelli; Fiscal Year: 2004
    ..Aim 3 will determine the effect of hyperlipidemia on cartilaginous metaplasia, vascular calcification and osteoporosis in a mouse model of atherosclerosis...
  17. TRANSCRIPTIONAL REGULATORS OF CHONDROINDUCTION BY DBP
    Karen Yates; Fiscal Year: 2004
    ..We will determine which DBP-regulated transcription factors are necessary and/or sufficient for postnatal chondrogenesis. This proposed work would have a high impact of design of strategies for repair and/or regeneration of cartilage. ..
  18. Function of the chromosomal kinase haspin in mitosis
    JONATHAN M HIGGINS; Fiscal Year: 2010
    ..A greater knowledge of the role of human haspin in this process will help us understand the defects that underlie transformation and may lead to new approaches to block the division of cancer cells. ..
  19. COAT-Platelets
    George Dale; Fiscal Year: 2005
    ..abstract_text> ..
  20. DETERMINANTS OF NEURONAL CONNECTIVITY IN THE COCHLEA
    DONNA WHITLON; Fiscal Year: 2005
    ..But in addition, the results will be relevant to questions of neural regeneration and bear on experimental attempts to encourage re-establishment of functional nerve fiber networks in the cochlea after nerve damage. ..
  21. VZV BACs: New Tools for Pathogenesis Research
    Nikolaus Osterrieder; Fiscal Year: 2005
    ..B-scid/beige mice, and infected MeWo or MeWo-9 cells will be used to inoculate the grafts. Virus replication in the implants will be examined by virus titrations, real-time PCR, histopathology and immunohistochemistry. ..
  22. WNT PROTEINS IN ADULT, AGED AND OSTEOARTHRITIC CARTILAGE
    Karen Yates; Fiscal Year: 2005
    ..This work will also provide a solid foundation for future research on Wnts in cartilage biology. ..
  23. Motif-based elucidation of protein modification codes
    JONATHAN HIGGINS; Fiscal Year: 2006
    ..The development of methodology to determine the functional impact of these marks is therefore a critical requirement for future work in all areas of biomedicine. [unreadable] [unreadable]..
  24. TELOMERE DYSFUNCTION, GENOMIC INSTABILITY AND CANCER
    Steven Artandi; Fiscal Year: 2005
    ..Transplantation experiments using this model will reveal if the effect on tumor biology is a cell autonomous one. ..