Genomes and Genes
Summary: Cell surface proteins that bind cytokines and trigger intracellular changes influencing the behavior of cells.
Publications342 found, 100 shown here
- HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5T Dragic
The Aaron Diamond AIDS Research Center, The Rockefeller University, New York 10016, USA
Nature 381:667-73. 1996..CC-CKR-5 is a second receptor for NSI primary viruses...
- CXC chemokine receptor 5 expression defines follicular homing T cells with B cell helper functionP Schaerli
Theodor Kocher Institute, University of Bern, CH 3000 Bern 9, Switzerland
J Exp Med 192:1553-62. 2000..These properties portray CXCR5(+) T cells as a distinct memory T cell subset with B cell helper function, designated here as follicular B helper T cells (T(FH))...
- Jak2 is essential for signaling through a variety of cytokine receptorsE Parganas
Howard Hughes Medical Institute, Department of Biochemistry, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
Cell 93:385-95. 1998..Therefore, Jak2 plays a critical, nonredundant role in the function of a specific group of cytokines receptors...
- Cytokine receptors and signaling in hepatic stellate cellsM Pinzani
Dipartimento di Medicina Interna, Universita degli Studi di Firenze, Viale Morgagni, 85, I 50134 Florence, Italy
Semin Liver Dis 21:397-416. 2001..In the past decade the major intracellular signaling pathways elicited by these factors in HSCs have been greatly elucidated...
- A role for TSLP in the development of inflammation in an asthma modelAmin Al-Shami
Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
J Exp Med 202:829-39. 2005..This underscores an important role for this cytokine in the development of inflammatory and/or allergic responses in vivo...
- Jaks and cytokine receptors--an intimate relationshipClaude Haan
Laboratoire de Biologie et Physiologie Intégrée LBPI, University of Luxembourg, 162A Avenue de la Faïencerie, L 1511 Luxembourg, Luxembourg
Biochem Pharmacol 72:1538-46. 2006Most cytokine receptors lack intrinsic kinase activity and many of them signal via Janus kinases (Jaks)...
- Chemokine receptor specific for IP10 and mig: structure, function, and expression in activated T-lymphocytesM Loetscher
Theodor Kocher Institute, University of Bern, Switzerland
J Exp Med 184:963-9. 1996..g., MCP-1, MCP-2, MCP-3, MIP-1 alpha, MIP-1 beta, and RANTES, are also found in monocytes and granulocytes. The present observations suggest that the IP10/Mig receptor is involved in the selective recruitment of effector T cells...
- B cell-attracting chemokine 1, a human CXC chemokine expressed in lymphoid tissues, selectively attracts B lymphocytes via BLR1/CXCR5D F Legler
Theodor Kocher Institute, University of Bern, CH 3000 Bern 9, Switzerland
J Exp Med 187:655-60. 1998....
- Molecular cloning of human eotaxin, an eosinophil-selective CC chemokine, and identification of a specific eosinophil eotaxin receptor, CC chemokine receptor 3M Kitaura
Shionogi Institute for Medical Science, Osaka, Japan
J Biol Chem 271:7725-30. 1996....
- Gp78 cooperates with RMA1 in endoplasmic reticulum-associated degradation of CFTRDeltaF508Daisuke Morito
Department of Molecular and Cellular Biology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606 8397, Japan
Mol Biol Cell 19:1328-36. 2008..Our data demonstrates that gp78 cooperates with RMA1 with E4-like activity in the ERAD of CFTRDeltaF508...
- Thymic stromal lymphopoietin is released by human epithelial cells in response to microbes, trauma, or inflammation and potently activates mast cellsZoulfia Allakhverdi
Laboratory on Allergy, CHUM Research Center, Notre Dame Hospital, Montreal, Quebec H2L 4M1, Canada
J Exp Med 204:253-8. 2007..Direct epithelial cell-mediated, TSLP-dependent activation of MCs may play a central role in "intrinsic" forms of atopic diseases and explain the aggravating role of infection and scratching in these diseases...
- Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expressionFranz G Bauernfeind
Department of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, MA 01605, USA
J Immunol 183:787-91. 2009..Pattern recognition and cytokine receptors control pro-IL-1beta transcription whereas inflammasomes regulate the proteolytic processing of pro-IL-1beta...
- The biology of human natural killer-cell subsetsM A Cooper
Dept of Veterinary Biosciences and Comprehensive Cancer Center, The Ohio State University, 458A Starling-Loving Hall, 320 West 10th Ave, Columbus, OH 43210, USA
Trends Immunol 22:633-40. 2001..In addition, we will discuss other cell-surface receptors expressed differentially by human NK-cell subsets and the distinct functional properties of these subsets...
- Defects in the generation of IFN-gamma are overcome to control infection with Leishmania donovani in CC chemokine receptor (CCR) 5-, macrophage inflammatory protein-1 alpha-, or CCR2-deficient miceN Sato
South Texas Veterans Health Care System, Audie L Murphy Division, Department of Medicine, University of Texas Health Science Center, San Antonio 78229, USA
J Immunol 163:5519-25. 1999..donovani infection. Our data also suggest that there might be cross-talk between TCR and chemokine receptor signaling pathways...
- The IL-27 receptor chain WSX-1 differentially regulates antibacterial immunity and survival during experimental tuberculosisChristoph Holscher
Junior Research Group Molecular Infection Biology, Research Center Borstel, Borstel, Germany
J Immunol 174:3534-44. 2005..In conclusion, IL-27 both prevents optimal antimycobacterial protection and limits the pathological sequelae of chronic inflammation...
- Cytokines, chemokines, and cytokine receptors in human microgliaYong B Lee
Division of Neurology, Department of Medicine, University of British Columbia, Vancouver, Canada
J Neurosci Res 69:94-103. 2002....
- WSX-1 is required for the initiation of Th1 responses and resistance to L. major infectionH Yoshida
The Amgen Institute, Toronto, Ontario M5G 2C1, Canada
Immunity 15:569-78. 2001..Thus, WSX-1 is essential for the initial mounting of Th1 responses but dispensable for their maintenance...
- Identification of CCR6, the specific receptor for a novel lymphocyte-directed CC chemokine LARCM Baba
Shionogi Institute for Medical Science, 2 5 1 Mishima, Settsu shi, Osaka 566, Japan
J Biol Chem 272:14893-8. 1997..Taken together, GPR-CY4 is the specific receptor for LARC expressed selectively on lymphocytes, and LARC is a unique functional ligand for GPR-CY4. We propose GPR-CY4 to be designated as CCR6...
- Ectopic expression of the B cell-attracting chemokine BCA-1 (CXCL13) on endothelial cells and within lymphoid follicles contributes to the establishment of germinal center-like structures in SjÃ¶gren's syndromeN Amft
Medical Research Council Centre for Immune Regulation, University of Birmingham, Edgbaston, UK
Arthritis Rheum 44:2633-41. 2001....
- CD4+CD3- cells induce Peyer's patch development: role of alpha4beta1 integrin activation by CXCR5D Finke
Institute of Biochemistry, University of Lausanne, Epalinges, Switzerland
Immunity 17:363-73. 2002..This study demonstrates the link between chemokine receptors and adhesion molecules that regulates stromal/hematopoietic cell interaction leading to PP formation...
- Cytokine and cytokine receptor pleiotropy and redundancyKatsutoshi Ozaki
Laboratory of Molecular Immunology, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892 1674, USA
J Biol Chem 277:29355-8. 2002
- The beta-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolatesH Choe
Division of Human Retrovirology Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
Cell 85:1135-48. 1996..The ability of various members of the chemokine receptor family to support the early stages of HIV-1 infection helps to explain viral tropism and beta-chemokine inhibition of primary HIV-1 isolates...
- Molecular cloning and functional characterization of a novel human CC chemokine receptor (CCR5) for RANTES, MIP-1beta, and MIP-1alphaC J Raport
ICOS Corporation, Bothell, Washington 98021, USA
J Biol Chem 271:17161-6. 1996..CCR5 is expressed in lymphoid organs such as thymus and spleen, as well as in peripheral blood leukocytes, including macrophages and T cells, and is the first example of a human chemokine receptor that signals in response to MIP-1beta...
- Cytokine and cytokine receptor gene polymorphisms and their functionalityAndrew J P Smith
Centre for Cardiovascular Genetics, Department of Medicine, University College London, United Kingdom
Cytokine Growth Factor Rev 20:43-59. 2009....
- A dual-tropic primary HIV-1 isolate that uses fusin and the beta-chemokine receptors CKR-5, CKR-3, and CKR-2b as fusion cofactorsB J Doranz
Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia 19104, USA
Cell 85:1149-58. 1996....
- Dual oncostatin M (OSM) receptors. Cloning and characterization of an alternative signaling subunit conferring OSM-specific receptor activationB Mosley
Immunex Corporation, Seattle, Washington 98101, USA
J Biol Chem 271:32635-43. 1996....
- Gp78, an ER associated E3, promotes SOD1 and ataxin-3 degradationZheng Ying
Laboratory of Molecular Neuropathology, Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences, University of Science and Technology of China, Anhui, People s Republic of China
Hum Mol Genet 18:4268-81. 2009..Furthermore, gp78 is increased in cells transfected with these two mutant proteins as well as in ALS mice. Thus, our results suggest that gp78 functions in the regulation of SOD1 and ataxin-3 to target them for ERAD...
- Cloning and functional expression of CC CKR5, a human monocyte CC chemokine receptor selective for MIP-1(alpha), MIP-1(beta), and RANTESC Combadiere
The Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
J Leukoc Biol 60:147-52. 1996..These data suggest that CC CKR5 is a G(i)-coupled receptor that may mediate monocyte responses to MIP-1alpha, MIP-1beta, and RANTES...
- Phylogeny and evolution of class-I helical cytokinesMark O Huising
Department of Animal Physiology, Institute for Neuroscience, Radboud University, Toernooiveld 1, 6525 ED Nijmegen, The Netherlands
J Endocrinol 189:1-25. 2006..as all class-I helical cytokines share a similar three-dimensional fold, signal via related class-I helical cytokine receptors and activate similar intracellular signalling cascades...
- Identification of a major co-receptor for primary isolates of HIV-1H Deng
Skirball Institute for Biomolecular Medicine, New York University Medical Center, 10016, USA
Nature 381:661-6. 1996..The principal cofactor for entry mediated by the envelope glycoproteins of primary macrophage-tropic strains of HIV-1 is CC-CKR-5, a receptor for the beta-chemokines RANTES, MIP-1alpha and MIP-1beta...
- Cutting edge: role of IL-27/WSX-1 signaling for induction of T-bet through activation of STAT1 during initial Th1 commitmentAtsunobu Takeda
Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, and Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
J Immunol 170:4886-90. 2003..Thus, during the initiation of Th1 differentiation, the IL-27/WSX-1 signaling system plays a pivotal role by STAT1-mediated T-bet induction before the IL-12R system...
- Two-sided roles of IL-27: induction of Th1 differentiation on naive CD4+ T cells versus suppression of proinflammatory cytokine production including IL-23-induced IL-17 on activated CD4+ T cells partially through STAT3-dependent mechanismTakeru Yoshimura
Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation and Department of Opthalmology, Graduate School of Medical Sciences Kyushu University, Fukuoka, Japan
J Immunol 177:5377-85. 2006..These data indicated that the preferential activation of STAT3 in fully activated CD4+ T cells plays an important role in the cytokine suppression by IL-27/WSX-1...
- The secreted form of p28 subunit of interleukin (IL)-27 inhibits biological functions of IL-27 and suppresses anti-allogeneic immune responsesOsamu Shimozato
Division of Pathology, Chiba Cancer Centre Research Institute, Nitona, Chiba, Japan
Immunology 128:e816-25. 2009..We propose that p28 can be a regulatory subunit for IL-27-mediated cellular immune responses and a possible therapeutic agent to suppress unfavourable immune responses...
- Thymic stromal lymphopoietin as a key initiator of allergic airway inflammation in miceBaohua Zhou
Immunology Program, Benaroya Research Institute, Seattle, Washington 98101, USA
Nat Immunol 6:1047-53. 2005..These findings suggest that TSLP is an important factor necessary and sufficient for the initiation of allergic airway inflammation...
- Ubiquitin ligase gp78 increases solubility and facilitates degradation of the Z variant of alpha-1-antitrypsinYuxian Shen
Institute of Clinical Pharmacology, Anhui Medical University, Anhui, PR China
Biochem Biophys Res Commun 349:1285-93. 2006..This effect can be partially inhibited by gp78 over-expression. These data indicate that gp78 assumes multiple unique quality control roles over ATZ, including the facilitation of degradation and inhibition of aggregation of ATZ...
- The ubiquitin ligase gp78 promotes sarcoma metastasis by targeting KAI1 for degradationYien Che Tsai
Laboratory of Protein Dynamics and Signaling, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, Maryland 21702, USA
Nat Med 13:1504-9. 2007....
- Overexpression of the tumor autocrine motility factor receptor Gp78, a ubiquitin protein ligase, results in increased ubiquitinylation and decreased secretion of apolipoprotein B100 in HepG2 cellsJun shan Liang
Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
J Biol Chem 278:23984-8. 2003..Together, these results indicate that an ER-associated protein, gp78, is a bona fide E3 ligase in the apoB ER-associated degradation pathway...
- Epstein-Barr virus-induced gene 3 and the p35 subunit of interleukin 12 form a novel heterodimeric hematopoietinO Devergne
Department of Medicine, Harvard Medical School and Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 94:12041-6. 1997..Because EBI3 is expressed in EBV-transformed B lymphocytes, tonsil, spleen, and placental trophoblasts, the EBI3/p35 heterodimer is likely to be an important immunomodulator...
- Class II cytokine receptors and their ligands: key antiviral and inflammatory modulatorsJean Christophe Renauld
Ludwig Institute for Cancer Research, Brussels Branch, and Experimental Medicine Unit, Universite de Louvain, 74 avenue Hippocrate, B1200 Brussels, Belgium
Nat Rev Immunol 3:667-76. 2003Class II cytokine receptors were originally defined on the basis of sequence homologies in the extracellular domains of receptors for interferons (IFNs) and interleukin-10 (IL-10), and the ligands, known as class II cytokines, also have a ..
- Cloning of STRL22, a new human gene encoding a G-protein-coupled receptor related to chemokine receptors and located on chromosome 6q27F Liao
Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
Genomics 40:175-80. 1997..In contrast to most chemokine receptor genes, the STRL22 coding sequence is not limited to a single exon...
- The structural and functional basis of cytokine receptor activation: lessons from the common beta subunit of the granulocyte-macrophage colony-stimulating factor, interleukin-3 (IL-3), and IL-5 receptorsC J Bagley
Department of Immunology, Hanson Centre for Cancer Research, Adelaide, Australia
Blood 89:1471-82. 1997
- Developing lymph nodes collect CD4+CD3- LTbeta+ cells that can differentiate to APC, NK cells, and follicular cells but not T or B cellsR E Mebius
Department of Cell Biology and Immunology, Faculty of Medicine, Vrije Universiteit, Amsterdam, The Netherlands
Immunity 7:493-504. 1997..Since the necessity of lymphotoxin in lymphoid organ development has been shown, we propose that the novel subset of CD4+CD3-LTbeta+ fetal cells is instrumental in the development of lymphoid tissue architecture...
- Chemokine receptor expression on B cells and effect of interferon-beta in multiple sclerosisTorben L Sørensen
The MS Clinic, Department of Neurology, University of Copenhagen, Glostrup Hospital, 2600 Glostrup, Denmark
J Neuroimmunol 122:125-31. 2002..Patients with active MS also had higher B-cell expression of CCR5 in blood. No major differences between RRMS and SPMS patients were detected, and chemokine receptor expression was not affected by interferon-beta treatment...
- Pro-thymocyte expansion by c-kit and the common cytokine receptor gamma chain is essential for repertoire formationH R Rodewald
Basel Institute for Immunology, Switzerland
Immunity 6:265-72. 1997....
- TNF-alpha modulates cytokine and cytokine receptors in C2C12 myotubesBelen Alvarez
Cancer Research Group, Departament de Bioquimica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Diagonal 645, 08028, Barcelona, Spain
Cancer Lett 175:181-5. 2002..The levels of expression of the two cytokine receptors were not changed by the cytokine at short-time intervals, but 48 h of treatment resulted in a decreased ..
- An amphipathic motif at the transmembrane-cytoplasmic junction prevents autonomous activation of the thrombopoietin receptorJudith Staerk
Ludwig Institute for Cancer Research, Universite Catholique de Louvain, Avenue Hippocrate 74, UCL 75 4, 1200 Brussels, Belgium
Blood 107:1864-71. 2006..Unlike other cytokine receptors, such as the erythropoietin receptor, TpoR contains an amphipathic KWQFP motif at the junction between the ..
- Neural precursor differentiation into astrocytes requires signaling through the leukemia inhibitory factor receptorS A Koblar
The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, 3050 Australia
Proc Natl Acad Sci U S A 95:3178-81. 1998..However, because this reduction is only partial it suggests that LIF may not be the predominant endogenous ligand signaling through the LIFR...
- Follicular B helper T cells express CXC chemokine receptor 5, localize to B cell follicles, and support immunoglobulin productionD Breitfeld
Molecular Tumor and Immunogenetics, Max Delbruck Center for Molecular Medicine, 13092 Berlin, Germany
J Exp Med 192:1545-52. 2000..Based on the characteristic localization within secondary lymphoid organs, we suggest to term these cells "follicular B helper T cells" (T(FH))...
- IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4+ T cellsStefan Pflanz
DNAX Research Institute, 901 California Avenue, Palo Alto, CA 94304, USA
Immunity 16:779-90. 2002..It also strongly synergizes with IL-12 to trigger IFN-gamma production of naive CD4(+) T cells. IL-27 mediates its biologic effects through the orphan cytokine receptor WSX-1/TCCR...
- Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathwayP C Heinrich
Institut fur Biochemie, RWTH Aachen, Universitatsklinikum, Pauwelsstrasse 30, D 52057 Aachen, Germany
Biochem J 334:297-314. 1998..of cytokine signalling), protein inhibitors of activated STATs (PIAS), and internalization of the cytokine receptors via gp130...
- Expression of cytokines and cytokine receptors in the rat brain after kainic acid-induced seizuresK A Lehtimäki
Department of Neurology and Rehabilitation, University of Tampere and Tampere University Hospital, PO Box 607, 33101 Tampere, Finland
Brain Res Mol Brain Res 110:253-60. 2003..Here we studied the expression of cytokines IL-6, LIF, IL-1beta and TNFalpha and cytokine receptors IL-6R, LIFR and Gp130 in the rat brain after kainic acid-induced status epilepticus using Northern blot ..
- Caveolin-1 is a negative regulator of caveolae-mediated endocytosis to the endoplasmic reticulumPhuong U Le
Department of Pathology and Cell Biology, Universite de Montreal, Montreal, Quebec H3C 3J7, Canada
J Biol Chem 277:3371-9. 2002..Caveolin-1 stabilizes the plasma membrane association of caveolae and thereby acts as a negative regulator of the caveolae-mediated endocytosis of AMF-R to the endoplasmic reticulum...
- BLyS: member of the tumor necrosis factor family and B lymphocyte stimulatorP A Moore
Human Genome Sciences, 9410 Key West Avenue, Rockville, MD 20850, USA
Science 285:260-3. 1999..The B cell tropism of BLyS is consistent with its receptor expression on B-lineage cells. The biological profile of BLyS suggests it is involved in monocyte-driven B cell activation...
- The IL-27 p28 subunit binds cytokine-like factor 1 to form a cytokine regulating NK and T cell activities requiring IL-6R for signalingSandrine Crabé
Departement de Pharmacologie, Universite de Montreal, Montreal, Canada
J Immunol 183:7692-702. 2009..The identification of a new IL-6R ligand is therefore important for a complete understanding of the mechanism of action of this emerging class of immunosuppressors...
- A chemokine-driven positive feedback loop organizes lymphoid folliclesK M Ansel
Department of Microbiology and Immunology, University of California San Francisco, 94143, USA
Nature 406:309-14. 2000..In germinal centres the feedback loop is overridden, with B-cell lymphotoxin alpha1beta2 expression being induced by a mechanism independent of BLC...
- Molecular cloning and functional expression of a new human CC-chemokine receptor geneM Samson
IRIBHN, Universite Libre de Bruxelles, Beligum
Biochemistry 35:3362-7. 1996..Being the fifth functionally identified receptor in his class, this new CC-chemokine receptor (CC-CKR) is tentatively designated CC-CKR5...
- Human thymic stromal lymphopoietin preferentially stimulates myeloid cellsP A Reche
DNAX Research Institute, Palo Alto, CA 94304, USA
J Immunol 167:336-43. 2001....
- Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17-producing T cellsMarcel Batten
Department of Molecular Biology, Genentech, South San Francisco, California 94080, USA
Nat Immunol 7:929-36. 2006..Finally, IL-27 suppressed IL-6-mediated T cell proliferation. These data provide a mechanistic explanation for the IL-27-mediated immune suppression noted in several in vivo models of inflammation...
- The IL-27R (WSX-1) is required to suppress T cell hyperactivity during infectionAlejandro Villarino
Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, 3800 Spruce St, Philadelphia, PA 19104, USA
Immunity 19:645-55. 2003....
- Signal transduction mediated by the Ras/Raf/MEK/ERK pathway from cytokine receptors to transcription factors: potential targeting for therapeutic interventionF Chang
Department of Microbiology and Immunology, Brody School of Medicine at East Carolina University, Greenville, NC 27858, USA
Leukemia 17:1263-93. 2003..The prospects of targeting this pathway for therapeutic intervention in leukemia and other cancers will be evaluated...
- Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV-1 infectionR Liu
Aaron Diamond AIDS Research Center, Rockefeller University New York, New York 10016, USA
Cell 86:367-77. 1996..These findings indicate the importance of CKR-5 in HIV-1 transmission and suggest that targeting the HIV-1-CKR-5 interaction may provide a means of preventing or slowing disease progression...
- Development of Th1-type immune responses requires the type I cytokine receptor TCCRQ Chen
Department of Molecular Oncology, Genentech, Inc, South San Francisco, California 94080, USA
Nature 407:916-20. 2000..Our results demonstrate the existence of a new cytokine receptor involved in regulating the adaptive immune response and critical to the generation of a Th1 response...
- Subspecialization of CXCR5+ T cells: B helper activity is focused in a germinal center-localized subset of CXCR5+ T cellsC H Kim
Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA
J Exp Med 193:1373-81. 2001..Our results demonstrate that CXCR5+ T cells are functionally heterogeneous and that the GC-Th cells, a small subset of CXCR5+ T cells, are the key helpers for B cell differentiation and antibody production in lymphoid tissues...
- Gp78, a membrane-anchored ubiquitin ligase, associates with Insig-1 and couples sterol-regulated ubiquitination to degradation of HMG CoA reductaseBao Liang Song
Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
Mol Cell 19:829-40. 2005..The current results identify gp78 as the E3 that initiates sterol-accelerated degradation of reductase, and Insig-1 as a bridge between gp78/VCP and the reductase substrate...
- A putative chemokine receptor, BLR1, directs B cell migration to defined lymphoid organs and specific anatomic compartments of the spleenR Forster
Max Delbruck Center for Molecular Medicine, Berlin Buch, Germany
Cell 87:1037-47. 1996..Our results identify the putative chemokine receptor BLR1 as the first G protein-coupled receptor involved in B cell migration and localization of these cells within specific anatomic compartments...
- Molecular cloning and RNA expression of two new human chemokine receptor-like genesA Zaballos
Research Department, Pharmacia and Upjohn, Madrid, Spain
Biochem Biophys Res Commun 227:846-53. 1996..CKR-L1 expression was also detected in monocyte/macrophages. The homology to chemokine receptors suggests that CKR-L1 belongs to the family of beta chemokine receptors, while CKR-L3 is more similar to alpha chemokine receptors...
- Cytokines and cytokine receptors in advanced heart failure: an analysis of the cytokine database from the Vesnarinone trial (VEST)A Deswal
Winters Center for Heart Failure Research, Department of Medicine, Veterans Affairs Medical Center and Baylor College of Medicine, Houston, TX 77030, USA
Circulation 103:2055-9. 2001BACKGROUND: Previous reports have shown that elevated circulating levels of cytokines and/or cytokine receptors predict adverse outcomes in patients with heart failure...
- Molecular cloning and characterization of a human eotaxin receptor expressed selectively on eosinophilsP D Ponath
LeukoSite, Inc, Cambridge, Massachusetts 02142, USA
J Exp Med 183:2437-48. 1996..The restricted expression of CKR-3 on eosinophils and the fidelity of eotaxin binding to CKR-3, provides a potential mechanism for the selective recruitment and migration of eosinophils within tissues...
- The relationship between circulating concentrations of C-reactive protein, inflammatory cytokines and cytokine receptors in patients with non-small-cell lung cancerD J McKeown
University Department of Surgery, Royal Infirmary, Glasgow G31 2ER, UK
Br J Cancer 91:1993-5. 2004..616, P<0.001). Interleukin-6 is an important independent mediator of elevated C-reactive protein concentrations in patients with non-small-cell lung cancer...
- TEF, an antiapoptotic bZIP transcription factor related to the oncogenic E2A-HLF chimera, inhibits cell growth by down-regulating expression of the common beta chain of cytokine receptorsTakeshi Inukai
Department of Pediatrics, School of Medicine, University of Yamanashi, 1110 Shimokato, Tamaho cho, Nakakoma gun, Yamanashi 409 3898, Japan
Blood 105:4437-44. 2005..Unexpectedly, TEF also almost completely down-regulated expression of the common beta (betac) chain of cytokine receptors. Consequently, TEF-expressing cells accumulated in G(0)/G(1) phase without undergoing apoptosis...
- The role of cerebral vascular NFkappaB in LPS-induced inflammation: differential regulation of efflux transporter and transporting cytokine receptorsWeihong Pan
Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
Cell Physiol Biochem 25:623-30. 2010..We determined the role of NFkappaB activation in regulatory changes of the P-glycoprotein (Pgp) drug efflux transporter at the blood-brain barrier (BBB) and proinflammatory cytokine receptors.
- Multiple sclerosis: cytokine receptors on oligodendrocytes predict innate regulationBarbara Cannella
Department of Pathology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
Ann Neurol 55:46-57. 2004..Remarkably, oligodendrocytes expressed all the cytokine receptors examined, particularly Th2-type, constitutively in normal subjects and upregulated in disease...
- Cytokine control of memory T-cell development and survivalKimberly S Schluns
Division of Immunology, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, Connecticut 06030 1319, USA
Nat Rev Immunol 3:269-79. 2003..In this manner, a stable and protective, long-lived memory CD8+ T-cell pool can be propagated and maintained...
- Human chemokines: an updateM Baggiolini
Theodor Kocher Institute, University of Bern, Switzerland
Annu Rev Immunol 15:675-705. 1997..Of considerable interest is the recent discovery that some chemokines function as HIV-suppressive factors by interacting with chemokine receptors which, together with CD4, were recognized as the binding sites for HIV-1...
- A coordinated change in chemokine responsiveness guides plasma cell movementsD C Hargreaves
Howard Hughes Medical Institute and Department of Microbiology and Immunology, University of California at San Francisco, San Francisco, CA 94143, USA
J Exp Med 194:45-56. 2001..Our findings indicate that as B cells differentiate into plasma cells they undergo a coordinated change in chemokine responsiveness that regulates their movements in secondary lymphoid organs and promotes lodgment within the bone marrow...
- Signaling from cytokine receptors that affect Th1 responsesAllison M Hanlon
Department of Microbiology and Immunology, Temple University School of Medicine, Philadelphia PA 19140, USA
Front Biosci 7:d1247-54. 2002..We will also discuss human immunodeficiencies resulting from mutations in the genes that encode the Type I cytokine receptors.
- 26. Immunomodulation and immunotherapy: drugs, cytokines, cytokine receptors, and antibodiesRobert P Nelson
Division of Hematology Oncology, Hematological Malignancy Program Immunology, Indiana University School of Medicine, 55 Barnhill Drive, Ste 473, Indianapolis, IN 46202, USA
J Allergy Clin Immunol 111:S720-43. 2003..These compounds will be discussed in terms of general principles, molecular targets, major indications, and adverse effects...
- Human B cell-attracting chemokine 1 (BCA-1; CXCL13) is an agonist for the human CXCR3 receptorC H Jenh
Department of Immunology, Schering Plough Research Institute, Kenilworth, NJ 07033, USA
Cytokine 15:113-21. 2001..The biological significance of this new finding is supported by our recent observation that human BCA-1 induces chemotaxis of activated T cells and the BCA-1-induced chemotaxis is inhibited by a monoclonal antibody against human CXCR3...
- Activation of small GTPase Rho is required for autocrine motility factor signalingSoichi Tsutsumi
Metastasis Research Program, Karmanos Cancer Institute and the Department of Pathology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
Cancer Res 62:4484-90. 2002..We thus conclude that AMF signaling shares a similar pathway to previously established paracrine factors signaling involving cytoskeletal rearrangement and morphological alterations mediated by the small RhoA-like GTPases...
- The IL-27 receptor (WSX-1) is an inhibitor of innate and adaptive elements of type 2 immunityDavid Artis
Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
J Immunol 173:5626-34. 2004..In addition, IL-27 directly suppressed CD4+ T cell proliferation and Th2 cytokine production. Together, these studies identify a novel role for IL-27/WSX-1 in limiting innate and adaptive components of type 2 immunity at mucosal sites...
- A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23RChristi Parham
Department of Immunology, DNAX Research, Palo Alto, CA 94304, USA
J Immunol 168:5699-708. 2002..The ability of cells to respond to IL-23 or IL-12 correlates with expression of IL-23R or IL-12Rbeta2, respectively. The human IL-23R gene is on human chromosome 1 within 150 kb of IL-12Rbeta2...
- Evaluation of serum levels of solubilized adhesion molecules and cytokine receptors in coronary heart diseaseM Porsch-Oezcueruemez
Institute for Clinical Chemistry, University of Regensburg, Germany
J Am Coll Cardiol 34:1995-2001. 1999..In addition, these variables were correlated with solubilized adhesion molecule levels (i.e., intracellular adhesion molecule [ICAM], vascular cell adhesion molecule [VCAM], and E-selectin)...
- The T cell-directed CC chemokine TARC is a highly specific biological ligand for CC chemokine receptor 4T Imai
Shionogi Institute for Medical Science, 2 5 1 Mishima, Settsu shi, Osaka 566, Japan
J Biol Chem 272:15036-42. 1997..Taken together, TARC is a specific functional ligand for CCR4, and CCR4 is the specific receptor for TARC selectively expressed on T cells...
- Cardiotrophin-1. Biological activities and binding to the leukemia inhibitory factor receptor/gp130 signaling complexD Pennica
Department of Molecular Biology, Genentech, Inc, South San Francisco, California 94080, USA
J Biol Chem 270:10915-22. 1995..These data show that CT-1 has a wide range of hematopoietic, neuronal, and developmental activities and that it can act via the LIF receptor and the gp130 signaling subunit...
- CLF associates with CLC to form a functional heteromeric ligand for the CNTF receptor complexG C Elson
Centre d Immunologie Pierre Fabre, 5 Avenue Napoleon III, 74164 St Julien en Genevois, France
Nat Neurosci 3:867-72. 2000..Our results indicate that the CLF/CLC complex is a second ligand for CNTFR with potentially important implications in nervous system development...
- Autocrine motility factor receptor: a clinical reviewConnie G Chiu
St Paul s Hospital, Department of Surgery, University of British Columbia, C303 1081 Burrard Street, Vancouver, BC, Canada
Expert Rev Anticancer Ther 8:207-17. 2008..Further characterization of AMFR in human cancer and the development of an understanding of the molecular regulation of this protein is critical for its future role as a target for anticancer agents...
- Serial measurement of serum cytokines, cytokine receptors and neopterin in leprosy patients with reversal reactionsW R Faber
Department of Pathology, Academic Medical Centre, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands
Lepr Rev 75:274-81. 2004Serum levels of cytokines (IL-4, IL-5, IFN-gamma, TNF-alpha), cytokine receptors (TNFR I and II) and one monokine (neopterin) were estimated in seven leprosy patients to establish disease associated markers for reversal reactions (RR)...
- Plasma levels of cytokines and soluble cytokine receptors during treatment with haloperidolT Pollmacher
Max Planck Institute of Psychiatry, Munich, Germany
Am J Psychiatry 154:1763-5. 1997Clozapine increases the levels of cytokines and soluble cytokine receptors. The authors investigated whether haloperidol has similar effects.
- Expression of Epstein-Barr virus-induced gene 3 and other interleukin-12-related molecules by human intestinal epitheliumChristian Maaser
Laboratory of Mucosal Immunology, Department of Medicine, University of California at San Diego, La Jolla, CA 92093, USA
Immunology 112:437-45. 2004....
- Regulation of cytokine receptors by Golgi N-glycan processing and endocytosisEmily A Partridge
Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, ON M5G 1X5, Canada
Science 306:120-4. 2004..Thus, conditional regulation of N-glycan processing drives synchronous modification of cytokine receptors, which balances their surface retention against loss via endocytosis.
- Deregulated TCR alpha beta T cell population provokes extramedullary hematopoiesis in mice deficient in the common gamma chainL I Sharara
INSERM U429, Hopital Necker, Paris, France
Eur J Immunol 27:990-8. 1997....
- Normal platelets and megakaryocytes are produced in vivo in the absence of thrombopoietinS Bunting
Department of Molecular Oncology, Genentech Inc, South San Francisco, CA 94080, USA
Blood 90:3423-9. 1997..Other factors with megakaryocytopoietic activity may be able to compensate for the maturational role of TPO and lead to the formation of normal megakaryocytes and platelets in TPO-/- and c-mpl-/- mice...
- The role of soluble receptors in cytokine biology: the agonistic properties of the sIL-6R/IL-6 complexSimon A Jones
Molecular Cell Biology Research Group, Cardiff School of Biosciences, Biomedical Sciences Building, Cardiff University, Wales, UK
Biochim Biophys Acta 1592:251-63. 2002..have placed considerable emphasis on identifying and characterising the regulatory properties of soluble cytokine receptors. These proteins bind their ligands with similar affinities to those of their cognate transmembrane receptors ..
- Loss of a gp130 cardiac muscle cell survival pathway is a critical event in the onset of heart failure during biomechanical stressH Hirota
UCSD Salk NHLBI Program in Molecular Medicine, Department of Medicine, La Jolla 920093, USA
Cell 97:189-98. 1999..Thus, cardiac myocyte apoptosis is a critical point in the transition between compensatory cardiac hypertrophy and heart failure. gp130-dependent cytokines may represent a novel therapeutic strategy for preventing in vivo heart failure...
- Oxygen tension modulates the expression of cytokine receptors, transcription factors, and lineage-specific markers in cultured human megakaryocytesS S Mostafa
Department of Chemical Engineering, Northwestern University, Evanston, IL 60208-3120, USA
Exp Hematol 29:873-83. 2001..CONCLUSION: These findings demonstrate that cytokine receptors c-Mpl and IL-3R, and Mk differentiation-specific surface receptors CD41a, CD42a, and NMDAR1, are ..
- In vivo roles of receptor tyrosine kinases and cytokine receptors in early thymocyte developmentJ P Di Santo
INSERM U429, Hopital Necker Enfants Malades, Paris, France
Curr Opin Immunol 10:196-207. 1998..The results obtained demonstrate that the development of all classes of lymphocytes (natural killer, gamma delta T cells and alpha beta T cells) is cytokine dependent, but the specific requirements differ for each lineage...
- Selective lymphocyte chemokine receptor expression in the rheumatoid jointJ H Ruth
Northwestern University Medical School, Department of Medicine, Section of Rheumatology, Chicago, IL 60611, USA
Arthritis Rheum 44:2750-60. 2001..CONCLUSION: These results identify CCR4, CCR5, CXCR3, and CX3CR1 as critical chemokine receptors in RA...
- Selective expression of the eotaxin receptor CCR3 by human T helper 2 cellsF Sallusto
Basel Institute for Immunology, Grenzacherstrasse 487, CH 4005 Basel, Switzerland
Science 277:2005-7. 1997..The attraction of TH2 cells by eotaxin could represent a key mechanism in allergic reactions, because it promotes the allergen-driven production of interleukin-4 and interleukin-5 necessary to activate basophils and eosinophils...
- The carboxyl-terminal domains of gp130-related cytokine receptors are necessary for suppressing embryonic stem cell differentiation. Involvement of STAT3M Ernst
Ludwig Institute for Cancer Research, Melbourne Tumour Biology Branch, P O Royal Melbourne Hospital, Victoria, 3050, Australia
J Biol Chem 274:9729-37. 1999..Thus, distinct cytoplasmic domains within the LIFRalpha, gp130, and GCSF-R transduce proliferative and differentiation suppressing signals...
- Expression and prognostic value of hemopoietic cytokine receptors in acute myeloid leukemia (AML): implications for future therapeutical strategiesMichaela Graf
Medical Department III, Klinikum Grosshadern, University of Munich, Germany
Eur J Haematol 72:89-106. 2004..Knowledge of individual cytokine receptor (CKR) profiles could provide new discoveries about CKR-supported therapeutic considerations...
- Shaping up adaptive immunity: the impact of CCR7 and CXCR5 on lymphocyte traffickingGerd Müller
Department of Molecular Tumor Genetics and Immunogenetics, Max Delbrück Center for Molecular Medicine MDC, Berlin, Germany
Microcirculation 10:325-34. 2003....
- Immune Regulation of Bone HomeostasisMERVYN NEALE WEITZMANN; Fiscal Year: 2012....
- Mechanisms of Endothelin 1-Induced Sickle Cell PathologyAlicia Rivera; Fiscal Year: 2011..ET-1 induces dehydration in vitro;the mouse SRBC Gardos channel is also coupled to ET-1 receptor and other cytokine receptors. Our preliminary data indicate that sickle transgenic mice treated with ET-1 receptor antagonists have ..
- Stem Cell Homing for Treatment of Female Pelvic Floor DisordersMargot S Damaser; Fiscal Year: 2013..Female LOXL1 KO mice will undergo vaginal delivery and will receive an infusion of MSCs in which homing cytokine receptors have been knocked down via transfection with small interfering RNA (siRNA)...
- Chronic Granulomatous Lung Inflammation Elicited by Carbon NanotubesMary Jane Thomassen; Fiscal Year: 2013..In summary, this unique investigation of MWCNT-elicited granulomatous lung disease is well suited for student participation in an area with environmental impact on human disease. ..
- 3D Skin Model to Test Toxic and Sensitizing Potentials of Environmental ChemicalsAkira Takashima; Fiscal Year: 2010..Once developed and validated, the resulting 3D skin model may enable the industry to eliminate the use of animals for skin toxicology studies. ..
- SIGNAL TRANSDUCTION MECHANISMS OF ERYTHROPOIETINBarbara A Miller; Fiscal Year: 2011..Therapeutic manipulation of TRPC3 activity may have wide applicability in regulating blood cell production, and hence have direct relevance in improving public health. ..
- Identification of Disease-Causing Mutations in SCID Using Exome-Wide SequencingJoseph L Roberts; Fiscal Year: 2010..etiologies of SCID were delineated by analysis of candidate genes that encode components of lymphocyte cytokine receptors, structural components of T cell receptor complex, products required for VDJ recombination, or proteins ..
- Cytokine Signaling in Neurons: Inflammation, Pain and PruritisMartin Steinhoff; Fiscal Year: 2013..The significance of this study is that it seeks to prove the concept that "classical immune" cytokine receptors act as important neuronal cytokine receptors on sensory nerves, thereby regulating skin inflammation, ..
- Regenerative Adjuvant Therapy for Stress Urinary IncontinenceMargot S Damaser; Fiscal Year: 2011..Specific projects to test stem cell homing as a possible adjuvant to rehabilitative treatments after polytrauma will be developed based on the outcome of the proposed work. ..
- Innate immunity in dermal fibrosis and systemic sclerosisROBERT A LAFYATIS; Fiscal Year: 2013..IL-4 and IL-13 in poly(I:C)-induced pump dermal fibrosis, using knock-out mice deleted of these cytokines or cytokine receptors. The second aim will investigate the dependence of this model on TLR3 and intracellular TRIF signaling ..
- Role of Surfactant in Innate and Adaptive ImmunityJo Rae Wright; Fiscal Year: 2010..mice to test the hypothesis that SP-A interacts with specific receptors to alter production of cytokines or cytokine receptors that inhibit dendritic cell maturation...
- Regulation of IL4 signal transduciton by poly (ADP-ribose) polymerase-1.Rahul Datta; Fiscal Year: 2011..Given the data demonstrating that PARP-1 inhibition abates of pulmonary inflammation in the mouse model of asthma, it is important to study the role of PARP-1 in inflammation in order to develop strategies in dealing with the disease. ..
- Growth Hormone Regulation of SH2-B1Christin Carter Su; Fiscal Year: 2009..abstract_text> ..
- Alcohol, Glial Gene Expression and the Heat Shock PathwayNeil L Harrison; Fiscal Year: 2010..We will study the effects of alcohol on the expression of cytokine IL-1b (Il1b), the cytokine receptors, IL-1R1 (Il1r1) and TLR4 (Tlr4) and the enzymes iNOS (Nos2) and COX-2 (COX2) in a MCG cell line...
- Aging, Inflammation and Exercise in Chronic StrokeAlice S Ryan; Fiscal Year: 2012..This research will identify a strategy to treat insulin resistance in stroke survivors and establish the biological basis for recommending lifestyle modifications to reduce inflammation and improve the metabolic profile in stroke. ..
- Targeting of alpha7 nAChR for therapeutic effectsRoger L Papke; Fiscal Year: 2013..We will use mammalian cells transfected with a7 alone, or in combination with pro-inflammatory cytokine receptors to test the hypothesis that drugs which induce stable desensitization of the a7 ion channel may still be ..
- Pathophysiology of Adult T-cell Leukemia/LymphomaUTPAL P DAVE; Fiscal Year: 2013..JAK3 is a non-receptor tyrosine kinase that binds with IL2RG to transduce signals from multiple cytokine receptors (IL2R, IL4R, IL7R, IL9R, IL15R, and IL21R) upon ligand binding...
- Role of HDAC7 in T-cell DevelopmentERIC M VERDIN; Fiscal Year: 2010..into distinct effector T cell subsets, depending on TCR activation as well as signaling through specific cytokine receptors. Perturbing the balance among these effector CD4+ T cells can lead to inflammation and/or autoimmunity, by ..
- Small Molecule Inhibitors for the Oncogenic Protein Tyrosine Phosphatase SHP2Zhong Yin Zhang; Fiscal Year: 2013..SHP2 is required for Ras/ERK1/2 activation downstream of most receptor tyrosine kinases, cytokine receptors, and integrins...
- Stat5b in Lymphomagenesis: Mechanistic and Therapeutic ImplicationsJohn A Kelly; Fiscal Year: 2012..Aim 3. Inhibit Stat5b TG lymphoma in vivo. Our data demonstrate that signals downstream of TCR and cytokine receptors promote lymphoma cell proliferation. Moreover, Stat5 up-regulates anti-apoptotic Bcl-2 family members...
- Amelioration of Immune Cell-Mediated Periodontal DiseaseToshihisa Kawai; Fiscal Year: 2012....
- Acetylation-Dependent IFN Signal TransductionY Eugene Chin; Fiscal Year: 2010..abstract_text> ..
- Effect of a viral replicon adjuvant on dendritic cell activityDANIEL TONKIN; Fiscal Year: 2010..Such findings can potentially be applied to any vaccine target, enabling the development of more effective vaccines. ..
- Growth Hormone Receptor Dimerization &Disulfide LinkageStuart J Frank; Fiscal Year: 2013..The knowledge gained and the development of inhibitory anti-GH receptor monoclonal antibodies as potential therapeutics may have broad relevance in our understanding of normal physiology and in treatment of cancer. ..
- Architectural Basis of Leptin Transmembrane SignalingGeorgios Skiniotis; Fiscal Year: 2013..will provide the general architectural framework for understanding how extracellular ligand binding on cytokine receptors results in intracellular JAK activation...
- Regulation of cyclin D3 in B lymphocyte developmentMarcus R Clark; Fiscal Year: 2013..In this grant application, we will determine how intracellular signals, delivered through the pre-BCR and cytokine receptors, integrate to direct complex developmental processes...
- Il-7 receptor signaling in lymphopoiesisMotonari Kondo; Fiscal Year: 2010..These two subunits are shared with other cytokine receptors: IL-7 receptor alpha chain is also a subunit of the functional thymic stromal lymphopoiesis receptor, while ..
- Functional biology of IL-25 during helminth infectionDavid Artis; Fiscal Year: 2012..Using cell lineage-specific deletions in transcription factors, cytokines or cytokine receptors, three specific aims of this project will determine (i) how IL-25 promotes TH2 cytokine responses, (ii) how ..
- Enhancing T Cell Therapy of CancerCliona M Rooney; Fiscal Year: 2013..This series of iterative laboratory and linked clinical studies is expected to yield strategies with the potential to increase cure rates and reduce treatment-related toxicity in patients with a spectrum of resistant solid tumors. ..
- Chronic Pain and Emotional Learning and MemoryAPKAR VANIA APKARIAN; Fiscal Year: 2012..Moreover, we seek to identify the role of endogenous cytokines, as markers for plasticity and learning, in the chronic pain. . ..
- T Cell Homeostasis in Systemic AutoimmunityArgyrios N Theofilopoulos; Fiscal Year: 2012..Aside from providing a new mechanistic concept, blockade of these mediators may constitute a novel therapeutic approach for lupus and other autoimmune diseases. ..
- Anti-polysaccharide antibody responses in humanized miceTIMOTHY L MANSER; Fiscal Year: 2013..We hypothesize that this is due, in part, to lack of efficient cross stimulation of human cytokine receptors on engrafting hematopoietic cells by host-produced murine cytokines...
- Natural Killer Cell Responses of Aged Mice to Primary Influenza InfectionElizabeth M Gardner; Fiscal Year: 2013..These three mouse models will afford a clear delineation of the specific contribution of NK cells in controlling the early response to influenza. ..
- Generation and Regulation of Anti-Viral CD4 T Cells with Cytolytic PotentialDeborah M Brown; Fiscal Year: 2013..abstract_text> ..
- Maintenance vs Programming in Th1 Memory Cell Development in P. Chabaudi MalariaRobin Stephens; Fiscal Year: 2013..same techniques I used in my dissertation work, and secondly;to study the indicative pattern of cytokines, cytokine receptors, transcription and chromatin tatistics factors to define mechanisms utilized by Th1 memory cells for ..
- Effect of HIV Infection and HAART on Bone HomeostasisMERVYN NEALE WEITZMANN; Fiscal Year: 2013..This proposal will investigate how HIV-induced perturbations in B cell function drives bone loss in HIV/AIDS, and examine the effects of different HAART formulations on this process, in animals and humans. ..
- Therapeutic vaccines for treatment of experimental autoimmune encephalomyelitis (Mark D Mannie; Fiscal Year: 2011..effector T cells and whether the cytokine domains of TTV require specific interactions with the respective cytokine receptors in vivo to elicit tolerance...
- Mechanisms of tumor resistance to anti-HER/ErbB therapeuticsZhen Fan; Fiscal Year: 2012..We will investigate this possibility. Our findings may indicate that EPO should not be administered to breast cancer patients who are being treated with trastuzumab. ..
- The role of the atypical PKCs in osteoclast functionJULIA THERESE WARREN; Fiscal Year: 2013..We propose to study the mechanisms by which the osteoclast, the sole bone resorbing cell, functions. This will help provide the foundations for novel therapeutic development to treat osteoporosis. ..
- Obesity and Allergic Airway HyperresponsivenessRICHARD ALAN JOHNSTON; Fiscal Year: 2013..which is characterized by increased serum concentrations of hormones, cytokines, chemokines, and soluble cytokine receptors. These substances, collectively termed adipokines, are largely pro-inflammatory in nature...
- The non-canonical NF-kappaB pathway in survival and function of T lymphocytesDavid C Parker; Fiscal Year: 2013..of these TNFR family members is necessary for induction and maintenance of expression of the cytokines, cytokine receptors, and anti-apoptotic proteins that allow T cells to survive and function as differentiated effector and ..
- Pro & Anti-Inflammatory Cytokines in Colorectal CancerGLORIA YF HO; Fiscal Year: 2010..Other cytokines and cytokine receptors, such as soluble TNF receptor types I and II (sTNF-R1 and sTNF-R2), IL-1 receptor antagonist (IL-1Ra), and ..
- CYTOPLASMIC LIPID BODIES OF INFLAMMATORY CELLSPeter F Weller; Fiscal Year: 2013..bodies and whether lipid body localized cytokines function locally within lipid bodies by signaling via cytokine receptors present within lipid bodies...
- Image-guided combination therapy: noninvasive assessment of delivery and responseSusanta K Sarkar; Fiscal Year: 2013..of tyrosine- kinase receptors represent a more potent approach as they inhibit functions of multiple cytokine receptors and have better delivery properties compared to monoclonal antibodies (mAb)...
- Dendritic Cells, Rapamycin and Transplant ToleranceAngus W Thomson; Fiscal Year: 2010..We will assess how RAPA affects signaling via Toll and cytokine receptors to maximize their tolerogenic potential;in AIM II, we will determine the optimal protocol for induction of ..
- A Novel Mouse Model of Temporal Lobe EpilepsyKaren S Wilcox; Fiscal Year: 2013..Preliminary data using C57BL/6 mice with various cytokines or cytokine receptors knocked-out have shown that these genetic manipulations can significantly alter the pathologic sequelae ..
- INTERLEUKIN 4 REGULATION OF LYMPHOCYTESMark R Boothby; Fiscal Year: 2010..question of general and fundamental significance about the rules which govern how selectivity is achieved by cytokine receptors in activating specific Stat transcription factors...
- Transmembrane Regulation of Ectodomain SheddingRenhao Li; Fiscal Year: 2012..from the host cell, affects a variety of biologically important proteins including growth factor precursors, cytokine receptors, amyloid precursor proteins and cell adhesion receptors, and proteoglycans...
- Repressor-PPAR Interactions in Inflammation and AtherosclerosisGrant D Barish; Fiscal Year: 2013..Work over the past two decades has identified pathways initiated through cell surface toll-like and cytokine receptors which culminate in the activation of NF-kB, AP1, and Stat proteins and subsequent transcriptional activation ..
- Non-Toll-like receptor innate immune signalingDavid M Underhill; Fiscal Year: 2012..In Aim 3 we will define the effect of the role of Dectin-1 and NFAT signaling in innate and adaptive immune responses in vivo. ..
- Targeting IL-12/23 p40 Pathways for the Control of GVHDXue Zhong Yu; Fiscal Year: 2013....
- Gene Therapy for SCID-X1 using a self-inactivating (SIN) gammaretroviral vectorDavid A Williams; Fiscal Year: 2013..This study will prove whether a safer gene therapy design will be effective without causing leukemia. ..
- Regulation of hematopoietic stem cell and progenitor cell proliferation by Runx1NANCY ASMUSSEN SPECK; Fiscal Year: 2013..8 to 36.3/100,000 after the age 70 years. There are currently 35,000 to 55,000 MDS cases in the United States. Understanding the molecular basis of this disease may enable us to find new drug targets. ..
- Opioid Impact on Trim37-Induced Restriction of HIVLAUREN BRITTANY BEACH; Fiscal Year: 2013..Given that many of the 33.4 million HIV-1 infected people worldwide use opioids, these studies have the potential to improve global human health among HIV-1 infected opioid users. ..
- Stat3 Isoforms in Maturation and Survival of Normal and Malignant Myeloid CellsMichele S Redell; Fiscal Year: 2012..applicant): Signal transducer and activator of transcription 3 (StatS) is a key signaling intermediate for cytokine receptors that regulate the survival, proliferation, and differentiation of myeloid progenitor cells...
- RESOURCE FOR NONHUMAN PRIMATE IMMUNE REAGENTSFRANCOIS J VILLINGER; Fiscal Year: 2013..2. Characterization and in vivo testing of soluble cytokine receptors as immune modulatory enhancers. 3...
- Signals Affecting Homestasis and Tolerance in Memory T CellsJonathan S Maltzman; Fiscal Year: 2013..processes are controlled via extracellular signals recognized by the clonotypic T cell receptor (TCR) and cytokine receptors. The relative contribution of TCR signals and cytokine receptor generated signals may vary depending on the ..
- Innate Immune Defense against Clostridium Difficile InfectionEric G Pamer; Fiscal Year: 2013..difficile infection and to discover practicable approaches, such as selective TLR or cytokine receptor stimulation or microbiota manipulation, to re-induce these mechanisms in vulnerable patients. ..
- Therapeutic Application of Small Molecule MIF Inhibitors in Rheumatoid ArthritisYoonsang Cho; Fiscal Year: 2013..To date, three MIF receptors have been reported: 1) an invariant chain CD74, and CXC cytokine receptors 2) CXCR2 and 3) CXCR4...
- Host Genetics of HIV-1 Subtype C Infection, Progression, and Treatment in AfricaMyron E Essex; Fiscal Year: 2010..factors, mitochondria! genes, selected immune response modifiers and HIV-1 co-receptors (cytokines and cytokine receptors, chemokines and chemokine receptors), HLA class 1 genes and host factors required for HIV-1 life cycle on: 1)..
- Regulation of neutrophil function and inflammation by ADAM17 during infectionBruce K Walcheck; Fiscal Year: 2010..shedding directs both instantaneous and prolonged alterations in the activity of various cytokines, cytokine receptors, and adhesion molecules...
- Control of Treg Homeostasis and Function by the Lipid Phosphatase PTENLaurence A Turka; Fiscal Year: 2013..Our studies will yield new insights into Treg signaling pathways and provide potential therapeutic strategies to enhance immune tolerance. ..
- Phase II, IL-1 Trap for Treatment of Familial Mediterranean FeverSteven J Spalding; Fiscal Year: 2010..In the long- term, better FMF control may prevent amyloidosis. This study may confirm the importance of IL-1 in the pathogenesis of FMF and provide support for an FDA filing for use of IL-1 Trap in FMF. ..
- MECHANISMS OF PULMONARY FIBROSIS CAUSED BY SILICAGerald Davis; Fiscal Year: 2003..And other interstitial lung diseases where the cause is not known and treatment is not effective. ..
- Tyrosine Phosphyorylation and Growth Hormone SignalingSTUART FRANK; Fiscal Year: 2005Growth hormone (GH) and prolactin (PRL) interact with GH and prolactin receptors (GHR; PRLR), both cytokine receptors, causing activation of the GHR- and PRLR-associated tyrosine kinase, JAK2, and the STATS and ERK pathways...
- GASTRIC CANCER INDUCED BY H PYLORI IN P27 DEFICIENT MICESteven Moss; Fiscal Year: 2009..We propose to evaluate a new mouse model of H. pylori-induced gastric cancer that we have developed, in order to address these important questions. ..
- STRUCTURE/FUNCTION OF THE SOLUBLE GM-CSF RECEPTORMARIBETH RAINES; Fiscal Year: 1999..Preliminary data from the PI suggest that sGMR-alpha may function differently from other soluble cytokine receptors in that it may associate with the signal transducing component of the GM-CSF receptor (betac) on the cell ..
- NF-kappaB Regulation by Androgen ReceptorALBERT BALDWIN JR; Fiscal Year: 2004..the immune and inflammatory response through its ability to control expression of genes encoding cytokines, cytokine receptors, and chemokines...
- Signal Transduction by Cytokine Receptors in VivoWarner Greene; Fiscal Year: 2004..Much remains to be learned about signal transduction specificity by these cytokine receptors. For example: 1)...
- SRC-LIKE KINASES IN INTERLEUKIN-3 RECEPTOR SIGNALINGSteven Anderson; Fiscal Year: 2001..It is hypothesized that Src-like kinases are required for mitogenic stimulation by cytokine receptors and, furthermore, that activation of the kinases is regulated by the binding of their SH2 domains to a ..
- Erythropoietin receptor /Janus Kinase 2 complexLily Huang; Fiscal Year: 2006..Unfortunately, little information is known about the structures of the cytoplasmic domain of any cytokine receptors, JAKs, or their complexes. This fellowship will probe the molecular structure of the EpoR/JAK2 complex...
- Gene Therapy for Purine Nucleoside Phosphorylase Deficiency (PNP)Kevin Baker; Fiscal Year: 2007..SCID), in which bone marrow cells from children deficient in the common gamma-chain for several cytokine receptors were exposed to a retrovirus encoding the missing gene and then reinfused into the patient...
- ANTIGEN-INDUCED B LYMPHOCYTE DEVELOPMENTDouglas Fearon; Fiscal Year: 2006..abstract_text> ..
- Identification of Biofilm-Induced Staphylococcus aureus Cytokine ReceptorsARLENE HOOGEWERF; Fiscal Year: 2006..Third, we will study the regulation of the cytokine receptors, and determine the contribution of biofilm cytokine binding to the increased evasion of host cellular ..
- GENE EXPRESSION IN CTCL PATIENTS IN IL 12 CLINICAL TRIALLouise Showe; Fiscal Year: 2001..An understanding of the genetic events that lead to tachyphylaxis could provide clues to alternate interim therapies that might reinduce IL-12 responsiveness. ..
- CLASS I MHC GENES EXPRESSED BY HUMAN TROPHOBLAST CELLSJOAN HUNT; Fiscal Year: 1999..of light chains, peptide transporters (TAP-1, TAP-2), proteasome components (LMP2, LMP7), cytokines and cytokine receptors may uniquely govern HLA class I expression in trophoblast cells...
- THROMBOPOIETIN SIGNAL TRANSDUCTIONJonathan Drachman; Fiscal Year: 2000..A better understanding of the mechanisms which underlie megakaryocytic development is a necessary prerequisite to providing new therapeutic options for patients with hematopoietic disorders. ..
- IL2 RECEPTORS--ANALYSIS OF ASSEMBLY AND SIGNALINGWarner Greene; Fiscal Year: 1999..appear to play a major role in growth signaling and both are members of a new and burgeoning super-family of cytokine receptors. The highly inducible and transient nature of alpha gene expression likely plays a central role in governing ..
- IL-7R and c-kit interactions in thymopoiesisKenneth Weinberg; Fiscal Year: 2006..abstract_text> ..