cytokine receptors


Summary: Cell surface proteins that bind cytokines and trigger intracellular changes influencing the behavior of cells.

Top Publications

  1. ncbi HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5
    T Dragic
    The Aaron Diamond AIDS Research Center, The Rockefeller University, New York 10016, USA
    Nature 381:667-73. 1996
  2. pmc CXC chemokine receptor 5 expression defines follicular homing T cells with B cell helper function
    P Schaerli
    Theodor Kocher Institute, University of Bern, CH 3000 Bern 9, Switzerland
    J Exp Med 192:1553-62. 2000
  3. ncbi Jak2 is essential for signaling through a variety of cytokine receptors
    E Parganas
    Howard Hughes Medical Institute, Department of Biochemistry, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Cell 93:385-95. 1998
  4. ncbi Cytokine receptors and signaling in hepatic stellate cells
    M Pinzani
    Dipartimento di Medicina Interna, Universita degli Studi di Firenze, Viale Morgagni, 85, I 50134 Florence, Italy
    Semin Liver Dis 21:397-416. 2001
  5. pmc A role for TSLP in the development of inflammation in an asthma model
    Amin Al-Shami
    Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 202:829-39. 2005
  6. ncbi Jaks and cytokine receptors--an intimate relationship
    Claude Haan
    Laboratoire de Biologie et Physiologie Intégrée LBPI, University of Luxembourg, 162A Avenue de la Faïencerie, L 1511 Luxembourg, Luxembourg
    Biochem Pharmacol 72:1538-46. 2006
  7. pmc Chemokine receptor specific for IP10 and mig: structure, function, and expression in activated T-lymphocytes
    M Loetscher
    Theodor Kocher Institute, University of Bern, Switzerland
    J Exp Med 184:963-9. 1996
  8. pmc B cell-attracting chemokine 1, a human CXC chemokine expressed in lymphoid tissues, selectively attracts B lymphocytes via BLR1/CXCR5
    D F Legler
    Theodor Kocher Institute, University of Bern, CH 3000 Bern 9, Switzerland
    J Exp Med 187:655-60. 1998
  9. ncbi Molecular cloning of human eotaxin, an eosinophil-selective CC chemokine, and identification of a specific eosinophil eotaxin receptor, CC chemokine receptor 3
    M Kitaura
    Shionogi Institute for Medical Science, Osaka, Japan
    J Biol Chem 271:7725-30. 1996
  10. pmc Gp78 cooperates with RMA1 in endoplasmic reticulum-associated degradation of CFTRDeltaF508
    Daisuke Morito
    Department of Molecular and Cellular Biology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606 8397, Japan
    Mol Biol Cell 19:1328-36. 2008

Detail Information

Publications342 found, 100 shown here

  1. ncbi HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5
    T Dragic
    The Aaron Diamond AIDS Research Center, The Rockefeller University, New York 10016, USA
    Nature 381:667-73. 1996
    ..CC-CKR-5 is a second receptor for NSI primary viruses...
  2. pmc CXC chemokine receptor 5 expression defines follicular homing T cells with B cell helper function
    P Schaerli
    Theodor Kocher Institute, University of Bern, CH 3000 Bern 9, Switzerland
    J Exp Med 192:1553-62. 2000
    ..These properties portray CXCR5(+) T cells as a distinct memory T cell subset with B cell helper function, designated here as follicular B helper T cells (T(FH))...
  3. ncbi Jak2 is essential for signaling through a variety of cytokine receptors
    E Parganas
    Howard Hughes Medical Institute, Department of Biochemistry, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Cell 93:385-95. 1998
    ..Therefore, Jak2 plays a critical, nonredundant role in the function of a specific group of cytokines receptors...
  4. ncbi Cytokine receptors and signaling in hepatic stellate cells
    M Pinzani
    Dipartimento di Medicina Interna, Universita degli Studi di Firenze, Viale Morgagni, 85, I 50134 Florence, Italy
    Semin Liver Dis 21:397-416. 2001
    ..In the past decade the major intracellular signaling pathways elicited by these factors in HSCs have been greatly elucidated...
  5. pmc A role for TSLP in the development of inflammation in an asthma model
    Amin Al-Shami
    Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 202:829-39. 2005
    ..This underscores an important role for this cytokine in the development of inflammatory and/or allergic responses in vivo...
  6. ncbi Jaks and cytokine receptors--an intimate relationship
    Claude Haan
    Laboratoire de Biologie et Physiologie Intégrée LBPI, University of Luxembourg, 162A Avenue de la Faïencerie, L 1511 Luxembourg, Luxembourg
    Biochem Pharmacol 72:1538-46. 2006
    Most cytokine receptors lack intrinsic kinase activity and many of them signal via Janus kinases (Jaks)...
  7. pmc Chemokine receptor specific for IP10 and mig: structure, function, and expression in activated T-lymphocytes
    M Loetscher
    Theodor Kocher Institute, University of Bern, Switzerland
    J Exp Med 184:963-9. 1996
    ..g., MCP-1, MCP-2, MCP-3, MIP-1 alpha, MIP-1 beta, and RANTES, are also found in monocytes and granulocytes. The present observations suggest that the IP10/Mig receptor is involved in the selective recruitment of effector T cells...
  8. pmc B cell-attracting chemokine 1, a human CXC chemokine expressed in lymphoid tissues, selectively attracts B lymphocytes via BLR1/CXCR5
    D F Legler
    Theodor Kocher Institute, University of Bern, CH 3000 Bern 9, Switzerland
    J Exp Med 187:655-60. 1998
  9. ncbi Molecular cloning of human eotaxin, an eosinophil-selective CC chemokine, and identification of a specific eosinophil eotaxin receptor, CC chemokine receptor 3
    M Kitaura
    Shionogi Institute for Medical Science, Osaka, Japan
    J Biol Chem 271:7725-30. 1996
  10. pmc Gp78 cooperates with RMA1 in endoplasmic reticulum-associated degradation of CFTRDeltaF508
    Daisuke Morito
    Department of Molecular and Cellular Biology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606 8397, Japan
    Mol Biol Cell 19:1328-36. 2008
    ..Our data demonstrates that gp78 cooperates with RMA1 with E4-like activity in the ERAD of CFTRDeltaF508...
  11. pmc Thymic stromal lymphopoietin is released by human epithelial cells in response to microbes, trauma, or inflammation and potently activates mast cells
    Zoulfia Allakhverdi
    Laboratory on Allergy, CHUM Research Center, Notre Dame Hospital, Montreal, Quebec H2L 4M1, Canada
    J Exp Med 204:253-8. 2007
    ..Direct epithelial cell-mediated, TSLP-dependent activation of MCs may play a central role in "intrinsic" forms of atopic diseases and explain the aggravating role of infection and scratching in these diseases...
  12. pmc Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression
    Franz G Bauernfeind
    Department of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    J Immunol 183:787-91. 2009
    ..Pattern recognition and cytokine receptors control pro-IL-1beta transcription whereas inflammasomes regulate the proteolytic processing of pro-IL-1beta...
  13. ncbi The biology of human natural killer-cell subsets
    M A Cooper
    Dept of Veterinary Biosciences and Comprehensive Cancer Center, The Ohio State University, 458A Starling-Loving Hall, 320 West 10th Ave, Columbus, OH 43210, USA
    Trends Immunol 22:633-40. 2001
    ..In addition, we will discuss other cell-surface receptors expressed differentially by human NK-cell subsets and the distinct functional properties of these subsets...
  14. ncbi Defects in the generation of IFN-gamma are overcome to control infection with Leishmania donovani in CC chemokine receptor (CCR) 5-, macrophage inflammatory protein-1 alpha-, or CCR2-deficient mice
    N Sato
    South Texas Veterans Health Care System, Audie L Murphy Division, Department of Medicine, University of Texas Health Science Center, San Antonio 78229, USA
    J Immunol 163:5519-25. 1999
    ..donovani infection. Our data also suggest that there might be cross-talk between TCR and chemokine receptor signaling pathways...
  15. ncbi The IL-27 receptor chain WSX-1 differentially regulates antibacterial immunity and survival during experimental tuberculosis
    Christoph Holscher
    Junior Research Group Molecular Infection Biology, Research Center Borstel, Borstel, Germany
    J Immunol 174:3534-44. 2005
    ..In conclusion, IL-27 both prevents optimal antimycobacterial protection and limits the pathological sequelae of chronic inflammation...
  16. ncbi Cytokines, chemokines, and cytokine receptors in human microglia
    Yong B Lee
    Division of Neurology, Department of Medicine, University of British Columbia, Vancouver, Canada
    J Neurosci Res 69:94-103. 2002
  17. ncbi WSX-1 is required for the initiation of Th1 responses and resistance to L. major infection
    H Yoshida
    The Amgen Institute, Toronto, Ontario M5G 2C1, Canada
    Immunity 15:569-78. 2001
    ..Thus, WSX-1 is essential for the initial mounting of Th1 responses but dispensable for their maintenance...
  18. ncbi Identification of CCR6, the specific receptor for a novel lymphocyte-directed CC chemokine LARC
    M Baba
    Shionogi Institute for Medical Science, 2 5 1 Mishima, Settsu shi, Osaka 566, Japan
    J Biol Chem 272:14893-8. 1997
    ..Taken together, GPR-CY4 is the specific receptor for LARC expressed selectively on lymphocytes, and LARC is a unique functional ligand for GPR-CY4. We propose GPR-CY4 to be designated as CCR6...
  19. ncbi Ectopic expression of the B cell-attracting chemokine BCA-1 (CXCL13) on endothelial cells and within lymphoid follicles contributes to the establishment of germinal center-like structures in Sjögren's syndrome
    N Amft
    Medical Research Council Centre for Immune Regulation, University of Birmingham, Edgbaston, UK
    Arthritis Rheum 44:2633-41. 2001
  20. ncbi CD4+CD3- cells induce Peyer's patch development: role of alpha4beta1 integrin activation by CXCR5
    D Finke
    Institute of Biochemistry, University of Lausanne, Epalinges, Switzerland
    Immunity 17:363-73. 2002
    ..This study demonstrates the link between chemokine receptors and adhesion molecules that regulates stromal/hematopoietic cell interaction leading to PP formation...
  21. ncbi Cytokine and cytokine receptor pleiotropy and redundancy
    Katsutoshi Ozaki
    Laboratory of Molecular Immunology, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892 1674, USA
    J Biol Chem 277:29355-8. 2002
  22. ncbi The beta-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates
    H Choe
    Division of Human Retrovirology Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Cell 85:1135-48. 1996
    ..The ability of various members of the chemokine receptor family to support the early stages of HIV-1 infection helps to explain viral tropism and beta-chemokine inhibition of primary HIV-1 isolates...
  23. ncbi Molecular cloning and functional characterization of a novel human CC chemokine receptor (CCR5) for RANTES, MIP-1beta, and MIP-1alpha
    C J Raport
    ICOS Corporation, Bothell, Washington 98021, USA
    J Biol Chem 271:17161-6. 1996
    ..CCR5 is expressed in lymphoid organs such as thymus and spleen, as well as in peripheral blood leukocytes, including macrophages and T cells, and is the first example of a human chemokine receptor that signals in response to MIP-1beta...
  24. doi Cytokine and cytokine receptor gene polymorphisms and their functionality
    Andrew J P Smith
    Centre for Cardiovascular Genetics, Department of Medicine, University College London, United Kingdom
    Cytokine Growth Factor Rev 20:43-59. 2009
  25. ncbi A dual-tropic primary HIV-1 isolate that uses fusin and the beta-chemokine receptors CKR-5, CKR-3, and CKR-2b as fusion cofactors
    B J Doranz
    Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia 19104, USA
    Cell 85:1149-58. 1996
  26. ncbi Dual oncostatin M (OSM) receptors. Cloning and characterization of an alternative signaling subunit conferring OSM-specific receptor activation
    B Mosley
    Immunex Corporation, Seattle, Washington 98101, USA
    J Biol Chem 271:32635-43. 1996
  27. doi Gp78, an ER associated E3, promotes SOD1 and ataxin-3 degradation
    Zheng Ying
    Laboratory of Molecular Neuropathology, Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences, University of Science and Technology of China, Anhui, People s Republic of China
    Hum Mol Genet 18:4268-81. 2009
    ..Furthermore, gp78 is increased in cells transfected with these two mutant proteins as well as in ALS mice. Thus, our results suggest that gp78 functions in the regulation of SOD1 and ataxin-3 to target them for ERAD...
  28. ncbi Cloning and functional expression of CC CKR5, a human monocyte CC chemokine receptor selective for MIP-1(alpha), MIP-1(beta), and RANTES
    C Combadiere
    The Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Leukoc Biol 60:147-52. 1996
    ..These data suggest that CC CKR5 is a G(i)-coupled receptor that may mediate monocyte responses to MIP-1alpha, MIP-1beta, and RANTES...
  29. ncbi Phylogeny and evolution of class-I helical cytokines
    Mark O Huising
    Department of Animal Physiology, Institute for Neuroscience, Radboud University, Toernooiveld 1, 6525 ED Nijmegen, The Netherlands
    J Endocrinol 189:1-25. 2006 all class-I helical cytokines share a similar three-dimensional fold, signal via related class-I helical cytokine receptors and activate similar intracellular signalling cascades...
  30. ncbi Identification of a major co-receptor for primary isolates of HIV-1
    H Deng
    Skirball Institute for Biomolecular Medicine, New York University Medical Center, 10016, USA
    Nature 381:661-6. 1996
    ..The principal cofactor for entry mediated by the envelope glycoproteins of primary macrophage-tropic strains of HIV-1 is CC-CKR-5, a receptor for the beta-chemokines RANTES, MIP-1alpha and MIP-1beta...
  31. ncbi Cutting edge: role of IL-27/WSX-1 signaling for induction of T-bet through activation of STAT1 during initial Th1 commitment
    Atsunobu Takeda
    Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, and Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Immunol 170:4886-90. 2003
    ..Thus, during the initiation of Th1 differentiation, the IL-27/WSX-1 signaling system plays a pivotal role by STAT1-mediated T-bet induction before the IL-12R system...
  32. ncbi Two-sided roles of IL-27: induction of Th1 differentiation on naive CD4+ T cells versus suppression of proinflammatory cytokine production including IL-23-induced IL-17 on activated CD4+ T cells partially through STAT3-dependent mechanism
    Takeru Yoshimura
    Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation and Department of Opthalmology, Graduate School of Medical Sciences Kyushu University, Fukuoka, Japan
    J Immunol 177:5377-85. 2006
    ..These data indicated that the preferential activation of STAT3 in fully activated CD4+ T cells plays an important role in the cytokine suppression by IL-27/WSX-1...
  33. pmc The secreted form of p28 subunit of interleukin (IL)-27 inhibits biological functions of IL-27 and suppresses anti-allogeneic immune responses
    Osamu Shimozato
    Division of Pathology, Chiba Cancer Centre Research Institute, Nitona, Chiba, Japan
    Immunology 128:e816-25. 2009
    ..We propose that p28 can be a regulatory subunit for IL-27-mediated cellular immune responses and a possible therapeutic agent to suppress unfavourable immune responses...
  34. ncbi Thymic stromal lymphopoietin as a key initiator of allergic airway inflammation in mice
    Baohua Zhou
    Immunology Program, Benaroya Research Institute, Seattle, Washington 98101, USA
    Nat Immunol 6:1047-53. 2005
    ..These findings suggest that TSLP is an important factor necessary and sufficient for the initiation of allergic airway inflammation...
  35. ncbi Ubiquitin ligase gp78 increases solubility and facilitates degradation of the Z variant of alpha-1-antitrypsin
    Yuxian Shen
    Institute of Clinical Pharmacology, Anhui Medical University, Anhui, PR China
    Biochem Biophys Res Commun 349:1285-93. 2006
    ..This effect can be partially inhibited by gp78 over-expression. These data indicate that gp78 assumes multiple unique quality control roles over ATZ, including the facilitation of degradation and inhibition of aggregation of ATZ...
  36. ncbi The ubiquitin ligase gp78 promotes sarcoma metastasis by targeting KAI1 for degradation
    Yien Che Tsai
    Laboratory of Protein Dynamics and Signaling, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, Maryland 21702, USA
    Nat Med 13:1504-9. 2007
  37. ncbi Overexpression of the tumor autocrine motility factor receptor Gp78, a ubiquitin protein ligase, results in increased ubiquitinylation and decreased secretion of apolipoprotein B100 in HepG2 cells
    Jun shan Liang
    Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    J Biol Chem 278:23984-8. 2003
    ..Together, these results indicate that an ER-associated protein, gp78, is a bona fide E3 ligase in the apoB ER-associated degradation pathway...
  38. pmc Epstein-Barr virus-induced gene 3 and the p35 subunit of interleukin 12 form a novel heterodimeric hematopoietin
    O Devergne
    Department of Medicine, Harvard Medical School and Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 94:12041-6. 1997
    ..Because EBI3 is expressed in EBV-transformed B lymphocytes, tonsil, spleen, and placental trophoblasts, the EBI3/p35 heterodimer is likely to be an important immunomodulator...
  39. ncbi Class II cytokine receptors and their ligands: key antiviral and inflammatory modulators
    Jean Christophe Renauld
    Ludwig Institute for Cancer Research, Brussels Branch, and Experimental Medicine Unit, Universite de Louvain, 74 avenue Hippocrate, B1200 Brussels, Belgium
    Nat Rev Immunol 3:667-76. 2003
    Class II cytokine receptors were originally defined on the basis of sequence homologies in the extracellular domains of receptors for interferons (IFNs) and interleukin-10 (IL-10), and the ligands, known as class II cytokines, also have a ..
  40. ncbi Cloning of STRL22, a new human gene encoding a G-protein-coupled receptor related to chemokine receptors and located on chromosome 6q27
    F Liao
    Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Genomics 40:175-80. 1997
    ..In contrast to most chemokine receptor genes, the STRL22 coding sequence is not limited to a single exon...
  41. ncbi The structural and functional basis of cytokine receptor activation: lessons from the common beta subunit of the granulocyte-macrophage colony-stimulating factor, interleukin-3 (IL-3), and IL-5 receptors
    C J Bagley
    Department of Immunology, Hanson Centre for Cancer Research, Adelaide, Australia
    Blood 89:1471-82. 1997
  42. ncbi Developing lymph nodes collect CD4+CD3- LTbeta+ cells that can differentiate to APC, NK cells, and follicular cells but not T or B cells
    R E Mebius
    Department of Cell Biology and Immunology, Faculty of Medicine, Vrije Universiteit, Amsterdam, The Netherlands
    Immunity 7:493-504. 1997
    ..Since the necessity of lymphotoxin in lymphoid organ development has been shown, we propose that the novel subset of CD4+CD3-LTbeta+ fetal cells is instrumental in the development of lymphoid tissue architecture...
  43. ncbi Chemokine receptor expression on B cells and effect of interferon-beta in multiple sclerosis
    Torben L Sørensen
    The MS Clinic, Department of Neurology, University of Copenhagen, Glostrup Hospital, 2600 Glostrup, Denmark
    J Neuroimmunol 122:125-31. 2002
    ..Patients with active MS also had higher B-cell expression of CCR5 in blood. No major differences between RRMS and SPMS patients were detected, and chemokine receptor expression was not affected by interferon-beta treatment...
  44. ncbi Pro-thymocyte expansion by c-kit and the common cytokine receptor gamma chain is essential for repertoire formation
    H R Rodewald
    Basel Institute for Immunology, Switzerland
    Immunity 6:265-72. 1997
  45. ncbi TNF-alpha modulates cytokine and cytokine receptors in C2C12 myotubes
    Belen Alvarez
    Cancer Research Group, Departament de Bioquimica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Diagonal 645, 08028, Barcelona, Spain
    Cancer Lett 175:181-5. 2002
    ..The levels of expression of the two cytokine receptors were not changed by the cytokine at short-time intervals, but 48 h of treatment resulted in a decreased ..
  46. pmc An amphipathic motif at the transmembrane-cytoplasmic junction prevents autonomous activation of the thrombopoietin receptor
    Judith Staerk
    Ludwig Institute for Cancer Research, Universite Catholique de Louvain, Avenue Hippocrate 74, UCL 75 4, 1200 Brussels, Belgium
    Blood 107:1864-71. 2006
    ..Unlike other cytokine receptors, such as the erythropoietin receptor, TpoR contains an amphipathic KWQFP motif at the junction between the ..
  47. pmc Neural precursor differentiation into astrocytes requires signaling through the leukemia inhibitory factor receptor
    S A Koblar
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, 3050 Australia
    Proc Natl Acad Sci U S A 95:3178-81. 1998
    ..However, because this reduction is only partial it suggests that LIF may not be the predominant endogenous ligand signaling through the LIFR...
  48. pmc Follicular B helper T cells express CXC chemokine receptor 5, localize to B cell follicles, and support immunoglobulin production
    D Breitfeld
    Molecular Tumor and Immunogenetics, Max Delbruck Center for Molecular Medicine, 13092 Berlin, Germany
    J Exp Med 192:1545-52. 2000
    ..Based on the characteristic localization within secondary lymphoid organs, we suggest to term these cells "follicular B helper T cells" (T(FH))...
  49. ncbi IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4+ T cells
    Stefan Pflanz
    DNAX Research Institute, 901 California Avenue, Palo Alto, CA 94304, USA
    Immunity 16:779-90. 2002
    ..It also strongly synergizes with IL-12 to trigger IFN-gamma production of naive CD4(+) T cells. IL-27 mediates its biologic effects through the orphan cytokine receptor WSX-1/TCCR...
  50. pmc Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway
    P C Heinrich
    Institut fur Biochemie, RWTH Aachen, Universitatsklinikum, Pauwelsstrasse 30, D 52057 Aachen, Germany
    Biochem J 334:297-314. 1998
    ..of cytokine signalling), protein inhibitors of activated STATs (PIAS), and internalization of the cytokine receptors via gp130...
  51. ncbi Expression of cytokines and cytokine receptors in the rat brain after kainic acid-induced seizures
    K A Lehtimäki
    Department of Neurology and Rehabilitation, University of Tampere and Tampere University Hospital, PO Box 607, 33101 Tampere, Finland
    Brain Res Mol Brain Res 110:253-60. 2003
    ..Here we studied the expression of cytokines IL-6, LIF, IL-1beta and TNFalpha and cytokine receptors IL-6R, LIFR and Gp130 in the rat brain after kainic acid-induced status epilepticus using Northern blot ..
  52. ncbi Caveolin-1 is a negative regulator of caveolae-mediated endocytosis to the endoplasmic reticulum
    Phuong U Le
    Department of Pathology and Cell Biology, Universite de Montreal, Montreal, Quebec H3C 3J7, Canada
    J Biol Chem 277:3371-9. 2002
    ..Caveolin-1 stabilizes the plasma membrane association of caveolae and thereby acts as a negative regulator of the caveolae-mediated endocytosis of AMF-R to the endoplasmic reticulum...
  53. ncbi BLyS: member of the tumor necrosis factor family and B lymphocyte stimulator
    P A Moore
    Human Genome Sciences, 9410 Key West Avenue, Rockville, MD 20850, USA
    Science 285:260-3. 1999
    ..The B cell tropism of BLyS is consistent with its receptor expression on B-lineage cells. The biological profile of BLyS suggests it is involved in monocyte-driven B cell activation...
  54. doi The IL-27 p28 subunit binds cytokine-like factor 1 to form a cytokine regulating NK and T cell activities requiring IL-6R for signaling
    Sandrine Crabé
    Departement de Pharmacologie, Universite de Montreal, Montreal, Canada
    J Immunol 183:7692-702. 2009
    ..The identification of a new IL-6R ligand is therefore important for a complete understanding of the mechanism of action of this emerging class of immunosuppressors...
  55. ncbi A chemokine-driven positive feedback loop organizes lymphoid follicles
    K M Ansel
    Department of Microbiology and Immunology, University of California San Francisco, 94143, USA
    Nature 406:309-14. 2000
    ..In germinal centres the feedback loop is overridden, with B-cell lymphotoxin alpha1beta2 expression being induced by a mechanism independent of BLC...
  56. ncbi Molecular cloning and functional expression of a new human CC-chemokine receptor gene
    M Samson
    IRIBHN, Universite Libre de Bruxelles, Beligum
    Biochemistry 35:3362-7. 1996
    ..Being the fifth functionally identified receptor in his class, this new CC-chemokine receptor (CC-CKR) is tentatively designated CC-CKR5...
  57. ncbi Human thymic stromal lymphopoietin preferentially stimulates myeloid cells
    P A Reche
    DNAX Research Institute, Palo Alto, CA 94304, USA
    J Immunol 167:336-43. 2001
  58. ncbi Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17-producing T cells
    Marcel Batten
    Department of Molecular Biology, Genentech, South San Francisco, California 94080, USA
    Nat Immunol 7:929-36. 2006
    ..Finally, IL-27 suppressed IL-6-mediated T cell proliferation. These data provide a mechanistic explanation for the IL-27-mediated immune suppression noted in several in vivo models of inflammation...
  59. ncbi The IL-27R (WSX-1) is required to suppress T cell hyperactivity during infection
    Alejandro Villarino
    Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, 3800 Spruce St, Philadelphia, PA 19104, USA
    Immunity 19:645-55. 2003
  60. ncbi Signal transduction mediated by the Ras/Raf/MEK/ERK pathway from cytokine receptors to transcription factors: potential targeting for therapeutic intervention
    F Chang
    Department of Microbiology and Immunology, Brody School of Medicine at East Carolina University, Greenville, NC 27858, USA
    Leukemia 17:1263-93. 2003
    ..The prospects of targeting this pathway for therapeutic intervention in leukemia and other cancers will be evaluated...
  61. ncbi Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV-1 infection
    R Liu
    Aaron Diamond AIDS Research Center, Rockefeller University New York, New York 10016, USA
    Cell 86:367-77. 1996
    ..These findings indicate the importance of CKR-5 in HIV-1 transmission and suggest that targeting the HIV-1-CKR-5 interaction may provide a means of preventing or slowing disease progression...
  62. ncbi Development of Th1-type immune responses requires the type I cytokine receptor TCCR
    Q Chen
    Department of Molecular Oncology, Genentech, Inc, South San Francisco, California 94080, USA
    Nature 407:916-20. 2000
    ..Our results demonstrate the existence of a new cytokine receptor involved in regulating the adaptive immune response and critical to the generation of a Th1 response...
  63. pmc Subspecialization of CXCR5+ T cells: B helper activity is focused in a germinal center-localized subset of CXCR5+ T cells
    C H Kim
    Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA
    J Exp Med 193:1373-81. 2001
    ..Our results demonstrate that CXCR5+ T cells are functionally heterogeneous and that the GC-Th cells, a small subset of CXCR5+ T cells, are the key helpers for B cell differentiation and antibody production in lymphoid tissues...
  64. ncbi Gp78, a membrane-anchored ubiquitin ligase, associates with Insig-1 and couples sterol-regulated ubiquitination to degradation of HMG CoA reductase
    Bao Liang Song
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Mol Cell 19:829-40. 2005
    ..The current results identify gp78 as the E3 that initiates sterol-accelerated degradation of reductase, and Insig-1 as a bridge between gp78/VCP and the reductase substrate...
  65. ncbi A putative chemokine receptor, BLR1, directs B cell migration to defined lymphoid organs and specific anatomic compartments of the spleen
    R Forster
    Max Delbruck Center for Molecular Medicine, Berlin Buch, Germany
    Cell 87:1037-47. 1996
    ..Our results identify the putative chemokine receptor BLR1 as the first G protein-coupled receptor involved in B cell migration and localization of these cells within specific anatomic compartments...
  66. ncbi Molecular cloning and RNA expression of two new human chemokine receptor-like genes
    A Zaballos
    Research Department, Pharmacia and Upjohn, Madrid, Spain
    Biochem Biophys Res Commun 227:846-53. 1996
    ..CKR-L1 expression was also detected in monocyte/macrophages. The homology to chemokine receptors suggests that CKR-L1 belongs to the family of beta chemokine receptors, while CKR-L3 is more similar to alpha chemokine receptors...
  67. ncbi Cytokines and cytokine receptors in advanced heart failure: an analysis of the cytokine database from the Vesnarinone trial (VEST)
    A Deswal
    Winters Center for Heart Failure Research, Department of Medicine, Veterans Affairs Medical Center and Baylor College of Medicine, Houston, TX 77030, USA
    Circulation 103:2055-9. 2001
    BACKGROUND: Previous reports have shown that elevated circulating levels of cytokines and/or cytokine receptors predict adverse outcomes in patients with heart failure...
  68. pmc Molecular cloning and characterization of a human eotaxin receptor expressed selectively on eosinophils
    P D Ponath
    LeukoSite, Inc, Cambridge, Massachusetts 02142, USA
    J Exp Med 183:2437-48. 1996
    ..The restricted expression of CKR-3 on eosinophils and the fidelity of eotaxin binding to CKR-3, provides a potential mechanism for the selective recruitment and migration of eosinophils within tissues...
  69. pmc The relationship between circulating concentrations of C-reactive protein, inflammatory cytokines and cytokine receptors in patients with non-small-cell lung cancer
    D J McKeown
    University Department of Surgery, Royal Infirmary, Glasgow G31 2ER, UK
    Br J Cancer 91:1993-5. 2004
    ..616, P<0.001). Interleukin-6 is an important independent mediator of elevated C-reactive protein concentrations in patients with non-small-cell lung cancer...
  70. ncbi TEF, an antiapoptotic bZIP transcription factor related to the oncogenic E2A-HLF chimera, inhibits cell growth by down-regulating expression of the common beta chain of cytokine receptors
    Takeshi Inukai
    Department of Pediatrics, School of Medicine, University of Yamanashi, 1110 Shimokato, Tamaho cho, Nakakoma gun, Yamanashi 409 3898, Japan
    Blood 105:4437-44. 2005
    ..Unexpectedly, TEF also almost completely down-regulated expression of the common beta (betac) chain of cytokine receptors. Consequently, TEF-expressing cells accumulated in G(0)/G(1) phase without undergoing apoptosis...
  71. pmc The role of cerebral vascular NFkappaB in LPS-induced inflammation: differential regulation of efflux transporter and transporting cytokine receptors
    Weihong Pan
    Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Cell Physiol Biochem 25:623-30. 2010
    ..We determined the role of NFkappaB activation in regulatory changes of the P-glycoprotein (Pgp) drug efflux transporter at the blood-brain barrier (BBB) and proinflammatory cytokine receptors.
  72. ncbi Multiple sclerosis: cytokine receptors on oligodendrocytes predict innate regulation
    Barbara Cannella
    Department of Pathology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Ann Neurol 55:46-57. 2004
    ..Remarkably, oligodendrocytes expressed all the cytokine receptors examined, particularly Th2-type, constitutively in normal subjects and upregulated in disease...
  73. ncbi Cytokine control of memory T-cell development and survival
    Kimberly S Schluns
    Division of Immunology, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, Connecticut 06030 1319, USA
    Nat Rev Immunol 3:269-79. 2003
    ..In this manner, a stable and protective, long-lived memory CD8+ T-cell pool can be propagated and maintained...
  74. ncbi Human chemokines: an update
    M Baggiolini
    Theodor Kocher Institute, University of Bern, Switzerland
    Annu Rev Immunol 15:675-705. 1997
    ..Of considerable interest is the recent discovery that some chemokines function as HIV-suppressive factors by interacting with chemokine receptors which, together with CD4, were recognized as the binding sites for HIV-1...
  75. pmc A coordinated change in chemokine responsiveness guides plasma cell movements
    D C Hargreaves
    Howard Hughes Medical Institute and Department of Microbiology and Immunology, University of California at San Francisco, San Francisco, CA 94143, USA
    J Exp Med 194:45-56. 2001
    ..Our findings indicate that as B cells differentiate into plasma cells they undergo a coordinated change in chemokine responsiveness that regulates their movements in secondary lymphoid organs and promotes lodgment within the bone marrow...
  76. ncbi Signaling from cytokine receptors that affect Th1 responses
    Allison M Hanlon
    Department of Microbiology and Immunology, Temple University School of Medicine, Philadelphia PA 19140, USA
    Front Biosci 7:d1247-54. 2002
    ..We will also discuss human immunodeficiencies resulting from mutations in the genes that encode the Type I cytokine receptors.
  77. ncbi 26. Immunomodulation and immunotherapy: drugs, cytokines, cytokine receptors, and antibodies
    Robert P Nelson
    Division of Hematology Oncology, Hematological Malignancy Program Immunology, Indiana University School of Medicine, 55 Barnhill Drive, Ste 473, Indianapolis, IN 46202, USA
    J Allergy Clin Immunol 111:S720-43. 2003
    ..These compounds will be discussed in terms of general principles, molecular targets, major indications, and adverse effects...
  78. ncbi Human B cell-attracting chemokine 1 (BCA-1; CXCL13) is an agonist for the human CXCR3 receptor
    C H Jenh
    Department of Immunology, Schering Plough Research Institute, Kenilworth, NJ 07033, USA
    Cytokine 15:113-21. 2001
    ..The biological significance of this new finding is supported by our recent observation that human BCA-1 induces chemotaxis of activated T cells and the BCA-1-induced chemotaxis is inhibited by a monoclonal antibody against human CXCR3...
  79. ncbi Activation of small GTPase Rho is required for autocrine motility factor signaling
    Soichi Tsutsumi
    Metastasis Research Program, Karmanos Cancer Institute and the Department of Pathology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Cancer Res 62:4484-90. 2002
    ..We thus conclude that AMF signaling shares a similar pathway to previously established paracrine factors signaling involving cytoskeletal rearrangement and morphological alterations mediated by the small RhoA-like GTPases...
  80. ncbi The IL-27 receptor (WSX-1) is an inhibitor of innate and adaptive elements of type 2 immunity
    David Artis
    Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Immunol 173:5626-34. 2004
    ..In addition, IL-27 directly suppressed CD4+ T cell proliferation and Th2 cytokine production. Together, these studies identify a novel role for IL-27/WSX-1 in limiting innate and adaptive components of type 2 immunity at mucosal sites...
  81. ncbi A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R
    Christi Parham
    Department of Immunology, DNAX Research, Palo Alto, CA 94304, USA
    J Immunol 168:5699-708. 2002
    ..The ability of cells to respond to IL-23 or IL-12 correlates with expression of IL-23R or IL-12Rbeta2, respectively. The human IL-23R gene is on human chromosome 1 within 150 kb of IL-12Rbeta2...
  82. ncbi Evaluation of serum levels of solubilized adhesion molecules and cytokine receptors in coronary heart disease
    M Porsch-Oezcueruemez
    Institute for Clinical Chemistry, University of Regensburg, Germany
    J Am Coll Cardiol 34:1995-2001. 1999
    ..In addition, these variables were correlated with solubilized adhesion molecule levels (i.e., intracellular adhesion molecule [ICAM], vascular cell adhesion molecule [VCAM], and E-selectin)...
  83. ncbi The T cell-directed CC chemokine TARC is a highly specific biological ligand for CC chemokine receptor 4
    T Imai
    Shionogi Institute for Medical Science, 2 5 1 Mishima, Settsu shi, Osaka 566, Japan
    J Biol Chem 272:15036-42. 1997
    ..Taken together, TARC is a specific functional ligand for CCR4, and CCR4 is the specific receptor for TARC selectively expressed on T cells...
  84. ncbi Cardiotrophin-1. Biological activities and binding to the leukemia inhibitory factor receptor/gp130 signaling complex
    D Pennica
    Department of Molecular Biology, Genentech, Inc, South San Francisco, California 94080, USA
    J Biol Chem 270:10915-22. 1995
    ..These data show that CT-1 has a wide range of hematopoietic, neuronal, and developmental activities and that it can act via the LIF receptor and the gp130 signaling subunit...
  85. ncbi CLF associates with CLC to form a functional heteromeric ligand for the CNTF receptor complex
    G C Elson
    Centre d Immunologie Pierre Fabre, 5 Avenue Napoleon III, 74164 St Julien en Genevois, France
    Nat Neurosci 3:867-72. 2000
    ..Our results indicate that the CLF/CLC complex is a second ligand for CNTFR with potentially important implications in nervous system development...
  86. doi Autocrine motility factor receptor: a clinical review
    Connie G Chiu
    St Paul s Hospital, Department of Surgery, University of British Columbia, C303 1081 Burrard Street, Vancouver, BC, Canada
    Expert Rev Anticancer Ther 8:207-17. 2008
    ..Further characterization of AMFR in human cancer and the development of an understanding of the molecular regulation of this protein is critical for its future role as a target for anticancer agents...
  87. ncbi Serial measurement of serum cytokines, cytokine receptors and neopterin in leprosy patients with reversal reactions
    W R Faber
    Department of Pathology, Academic Medical Centre, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands
    Lepr Rev 75:274-81. 2004
    Serum levels of cytokines (IL-4, IL-5, IFN-gamma, TNF-alpha), cytokine receptors (TNFR I and II) and one monokine (neopterin) were estimated in seven leprosy patients to establish disease associated markers for reversal reactions (RR)...
  88. ncbi Plasma levels of cytokines and soluble cytokine receptors during treatment with haloperidol
    T Pollmacher
    Max Planck Institute of Psychiatry, Munich, Germany
    Am J Psychiatry 154:1763-5. 1997
    Clozapine increases the levels of cytokines and soluble cytokine receptors. The authors investigated whether haloperidol has similar effects.
  89. pmc Expression of Epstein-Barr virus-induced gene 3 and other interleukin-12-related molecules by human intestinal epithelium
    Christian Maaser
    Laboratory of Mucosal Immunology, Department of Medicine, University of California at San Diego, La Jolla, CA 92093, USA
    Immunology 112:437-45. 2004
  90. ncbi Regulation of cytokine receptors by Golgi N-glycan processing and endocytosis
    Emily A Partridge
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, ON M5G 1X5, Canada
    Science 306:120-4. 2004
    ..Thus, conditional regulation of N-glycan processing drives synchronous modification of cytokine receptors, which balances their surface retention against loss via endocytosis.
  91. ncbi Deregulated TCR alpha beta T cell population provokes extramedullary hematopoiesis in mice deficient in the common gamma chain
    L I Sharara
    INSERM U429, Hopital Necker, Paris, France
    Eur J Immunol 27:990-8. 1997
  92. ncbi Normal platelets and megakaryocytes are produced in vivo in the absence of thrombopoietin
    S Bunting
    Department of Molecular Oncology, Genentech Inc, South San Francisco, CA 94080, USA
    Blood 90:3423-9. 1997
    ..Other factors with megakaryocytopoietic activity may be able to compensate for the maturational role of TPO and lead to the formation of normal megakaryocytes and platelets in TPO-/- and c-mpl-/- mice...
  93. ncbi The role of soluble receptors in cytokine biology: the agonistic properties of the sIL-6R/IL-6 complex
    Simon A Jones
    Molecular Cell Biology Research Group, Cardiff School of Biosciences, Biomedical Sciences Building, Cardiff University, Wales, UK
    Biochim Biophys Acta 1592:251-63. 2002
    ..have placed considerable emphasis on identifying and characterising the regulatory properties of soluble cytokine receptors. These proteins bind their ligands with similar affinities to those of their cognate transmembrane receptors ..
  94. ncbi Loss of a gp130 cardiac muscle cell survival pathway is a critical event in the onset of heart failure during biomechanical stress
    H Hirota
    UCSD Salk NHLBI Program in Molecular Medicine, Department of Medicine, La Jolla 920093, USA
    Cell 97:189-98. 1999
    ..Thus, cardiac myocyte apoptosis is a critical point in the transition between compensatory cardiac hypertrophy and heart failure. gp130-dependent cytokines may represent a novel therapeutic strategy for preventing in vivo heart failure...
  95. ncbi Oxygen tension modulates the expression of cytokine receptors, transcription factors, and lineage-specific markers in cultured human megakaryocytes
    S S Mostafa
    Department of Chemical Engineering, Northwestern University, Evanston, IL 60208-3120, USA
    Exp Hematol 29:873-83. 2001
    ..CONCLUSION: These findings demonstrate that cytokine receptors c-Mpl and IL-3R, and Mk differentiation-specific surface receptors CD41a, CD42a, and NMDAR1, are ..
  96. ncbi In vivo roles of receptor tyrosine kinases and cytokine receptors in early thymocyte development
    J P Di Santo
    INSERM U429, Hopital Necker Enfants Malades, Paris, France
    Curr Opin Immunol 10:196-207. 1998
    ..The results obtained demonstrate that the development of all classes of lymphocytes (natural killer, gamma delta T cells and alpha beta T cells) is cytokine dependent, but the specific requirements differ for each lineage...
  97. ncbi Selective lymphocyte chemokine receptor expression in the rheumatoid joint
    J H Ruth
    Northwestern University Medical School, Department of Medicine, Section of Rheumatology, Chicago, IL 60611, USA
    Arthritis Rheum 44:2750-60. 2001
    ..CONCLUSION: These results identify CCR4, CCR5, CXCR3, and CX3CR1 as critical chemokine receptors in RA...
  98. ncbi Selective expression of the eotaxin receptor CCR3 by human T helper 2 cells
    F Sallusto
    Basel Institute for Immunology, Grenzacherstrasse 487, CH 4005 Basel, Switzerland
    Science 277:2005-7. 1997
    ..The attraction of TH2 cells by eotaxin could represent a key mechanism in allergic reactions, because it promotes the allergen-driven production of interleukin-4 and interleukin-5 necessary to activate basophils and eosinophils...
  99. ncbi The carboxyl-terminal domains of gp130-related cytokine receptors are necessary for suppressing embryonic stem cell differentiation. Involvement of STAT3
    M Ernst
    Ludwig Institute for Cancer Research, Melbourne Tumour Biology Branch, P O Royal Melbourne Hospital, Victoria, 3050, Australia
    J Biol Chem 274:9729-37. 1999
    ..Thus, distinct cytoplasmic domains within the LIFRalpha, gp130, and GCSF-R transduce proliferative and differentiation suppressing signals...
  100. ncbi Expression and prognostic value of hemopoietic cytokine receptors in acute myeloid leukemia (AML): implications for future therapeutical strategies
    Michaela Graf
    Medical Department III, Klinikum Grosshadern, University of Munich, Germany
    Eur J Haematol 72:89-106. 2004
    ..Knowledge of individual cytokine receptor (CKR) profiles could provide new discoveries about CKR-supported therapeutic considerations...
  101. ncbi Shaping up adaptive immunity: the impact of CCR7 and CXCR5 on lymphocyte trafficking
    Gerd Müller
    Department of Molecular Tumor Genetics and Immunogenetics, Max Delbrück Center for Molecular Medicine MDC, Berlin, Germany
    Microcirculation 10:325-34. 2003

Research Grants79

  1. Immune Regulation of Bone Homeostasis
    MERVYN NEALE WEITZMANN; Fiscal Year: 2012
  2. Mechanisms of Endothelin 1-Induced Sickle Cell Pathology
    Alicia Rivera; Fiscal Year: 2011
    ..ET-1 induces dehydration in vitro;the mouse SRBC Gardos channel is also coupled to ET-1 receptor and other cytokine receptors. Our preliminary data indicate that sickle transgenic mice treated with ET-1 receptor antagonists have ..
  3. Stem Cell Homing for Treatment of Female Pelvic Floor Disorders
    Margot S Damaser; Fiscal Year: 2013
    ..Female LOXL1 KO mice will undergo vaginal delivery and will receive an infusion of MSCs in which homing cytokine receptors have been knocked down via transfection with small interfering RNA (siRNA)...
  4. Chronic Granulomatous Lung Inflammation Elicited by Carbon Nanotubes
    Mary Jane Thomassen; Fiscal Year: 2013
    ..In summary, this unique investigation of MWCNT-elicited granulomatous lung disease is well suited for student participation in an area with environmental impact on human disease. ..
  5. 3D Skin Model to Test Toxic and Sensitizing Potentials of Environmental Chemicals
    Akira Takashima; Fiscal Year: 2010
    ..Once developed and validated, the resulting 3D skin model may enable the industry to eliminate the use of animals for skin toxicology studies. ..
    Barbara A Miller; Fiscal Year: 2011
    ..Therapeutic manipulation of TRPC3 activity may have wide applicability in regulating blood cell production, and hence have direct relevance in improving public health. ..
  7. Identification of Disease-Causing Mutations in SCID Using Exome-Wide Sequencing
    Joseph L Roberts; Fiscal Year: 2010
    ..etiologies of SCID were delineated by analysis of candidate genes that encode components of lymphocyte cytokine receptors, structural components of T cell receptor complex, products required for VDJ recombination, or proteins ..
  8. Cytokine Signaling in Neurons: Inflammation, Pain and Pruritis
    Martin Steinhoff; Fiscal Year: 2013
    ..The significance of this study is that it seeks to prove the concept that "classical immune" cytokine receptors act as important neuronal cytokine receptors on sensory nerves, thereby regulating skin inflammation, ..
  9. Regenerative Adjuvant Therapy for Stress Urinary Incontinence
    Margot S Damaser; Fiscal Year: 2011
    ..Specific projects to test stem cell homing as a possible adjuvant to rehabilitative treatments after polytrauma will be developed based on the outcome of the proposed work. ..
  10. Innate immunity in dermal fibrosis and systemic sclerosis
    ROBERT A LAFYATIS; Fiscal Year: 2013
    ..IL-4 and IL-13 in poly(I:C)-induced pump dermal fibrosis, using knock-out mice deleted of these cytokines or cytokine receptors. The second aim will investigate the dependence of this model on TLR3 and intracellular TRIF signaling ..
  11. Role of Surfactant in Innate and Adaptive Immunity
    Jo Rae Wright; Fiscal Year: 2010
    ..mice to test the hypothesis that SP-A interacts with specific receptors to alter production of cytokines or cytokine receptors that inhibit dendritic cell maturation...
  12. Regulation of IL4 signal transduciton by poly (ADP-ribose) polymerase-1.
    Rahul Datta; Fiscal Year: 2011
    ..Given the data demonstrating that PARP-1 inhibition abates of pulmonary inflammation in the mouse model of asthma, it is important to study the role of PARP-1 in inflammation in order to develop strategies in dealing with the disease. ..
  13. Growth Hormone Regulation of SH2-B1
    Christin Carter Su; Fiscal Year: 2009
    ..abstract_text> ..
  14. Alcohol, Glial Gene Expression and the Heat Shock Pathway
    Neil L Harrison; Fiscal Year: 2010
    ..We will study the effects of alcohol on the expression of cytokine IL-1b (Il1b), the cytokine receptors, IL-1R1 (Il1r1) and TLR4 (Tlr4) and the enzymes iNOS (Nos2) and COX-2 (COX2) in a MCG cell line...
  15. Aging, Inflammation and Exercise in Chronic Stroke
    Alice S Ryan; Fiscal Year: 2012
    ..This research will identify a strategy to treat insulin resistance in stroke survivors and establish the biological basis for recommending lifestyle modifications to reduce inflammation and improve the metabolic profile in stroke. ..
  16. Targeting of alpha7 nAChR for therapeutic effects
    Roger L Papke; Fiscal Year: 2013
    ..We will use mammalian cells transfected with a7 alone, or in combination with pro-inflammatory cytokine receptors to test the hypothesis that drugs which induce stable desensitization of the a7 ion channel may still be ..
  17. Pathophysiology of Adult T-cell Leukemia/Lymphoma
    UTPAL P DAVE; Fiscal Year: 2013
    ..JAK3 is a non-receptor tyrosine kinase that binds with IL2RG to transduce signals from multiple cytokine receptors (IL2R, IL4R, IL7R, IL9R, IL15R, and IL21R) upon ligand binding...
  18. Role of HDAC7 in T-cell Development
    ERIC M VERDIN; Fiscal Year: 2010
    ..into distinct effector T cell subsets, depending on TCR activation as well as signaling through specific cytokine receptors. Perturbing the balance among these effector CD4+ T cells can lead to inflammation and/or autoimmunity, by ..
  19. Small Molecule Inhibitors for the Oncogenic Protein Tyrosine Phosphatase SHP2
    Zhong Yin Zhang; Fiscal Year: 2013
    ..SHP2 is required for Ras/ERK1/2 activation downstream of most receptor tyrosine kinases, cytokine receptors, and integrins...
  20. Stat5b in Lymphomagenesis: Mechanistic and Therapeutic Implications
    John A Kelly; Fiscal Year: 2012
    ..Aim 3. Inhibit Stat5b TG lymphoma in vivo. Our data demonstrate that signals downstream of TCR and cytokine receptors promote lymphoma cell proliferation. Moreover, Stat5 up-regulates anti-apoptotic Bcl-2 family members...
  21. Amelioration of Immune Cell-Mediated Periodontal Disease
    Toshihisa Kawai; Fiscal Year: 2012
  22. Acetylation-Dependent IFN Signal Transduction
    Y Eugene Chin; Fiscal Year: 2010
    ..abstract_text> ..
  23. Effect of a viral replicon adjuvant on dendritic cell activity
    DANIEL TONKIN; Fiscal Year: 2010
    ..Such findings can potentially be applied to any vaccine target, enabling the development of more effective vaccines. ..
  24. Growth Hormone Receptor Dimerization &Disulfide Linkage
    Stuart J Frank; Fiscal Year: 2013
    ..The knowledge gained and the development of inhibitory anti-GH receptor monoclonal antibodies as potential therapeutics may have broad relevance in our understanding of normal physiology and in treatment of cancer. ..
  25. Architectural Basis of Leptin Transmembrane Signaling
    Georgios Skiniotis; Fiscal Year: 2013
    ..will provide the general architectural framework for understanding how extracellular ligand binding on cytokine receptors results in intracellular JAK activation...
  26. Regulation of cyclin D3 in B lymphocyte development
    Marcus R Clark; Fiscal Year: 2013
    ..In this grant application, we will determine how intracellular signals, delivered through the pre-BCR and cytokine receptors, integrate to direct complex developmental processes...
  27. Il-7 receptor signaling in lymphopoiesis
    Motonari Kondo; Fiscal Year: 2010
    ..These two subunits are shared with other cytokine receptors: IL-7 receptor alpha chain is also a subunit of the functional thymic stromal lymphopoiesis receptor, while ..
  28. Functional biology of IL-25 during helminth infection
    David Artis; Fiscal Year: 2012
    ..Using cell lineage-specific deletions in transcription factors, cytokines or cytokine receptors, three specific aims of this project will determine (i) how IL-25 promotes TH2 cytokine responses, (ii) how ..
  29. Enhancing T Cell Therapy of Cancer
    Cliona M Rooney; Fiscal Year: 2013
    ..This series of iterative laboratory and linked clinical studies is expected to yield strategies with the potential to increase cure rates and reduce treatment-related toxicity in patients with a spectrum of resistant solid tumors. ..
  30. Chronic Pain and Emotional Learning and Memory
    APKAR VANIA APKARIAN; Fiscal Year: 2012
    ..Moreover, we seek to identify the role of endogenous cytokines, as markers for plasticity and learning, in the chronic pain. . ..
  31. T Cell Homeostasis in Systemic Autoimmunity
    Argyrios N Theofilopoulos; Fiscal Year: 2012
    ..Aside from providing a new mechanistic concept, blockade of these mediators may constitute a novel therapeutic approach for lupus and other autoimmune diseases. ..
  32. Anti-polysaccharide antibody responses in humanized mice
    TIMOTHY L MANSER; Fiscal Year: 2013
    ..We hypothesize that this is due, in part, to lack of efficient cross stimulation of human cytokine receptors on engrafting hematopoietic cells by host-produced murine cytokines...
  33. Natural Killer Cell Responses of Aged Mice to Primary Influenza Infection
    Elizabeth M Gardner; Fiscal Year: 2013
    ..These three mouse models will afford a clear delineation of the specific contribution of NK cells in controlling the early response to influenza. ..
  34. Generation and Regulation of Anti-Viral CD4 T Cells with Cytolytic Potential
    Deborah M Brown; Fiscal Year: 2013
    ..abstract_text> ..
  35. Maintenance vs Programming in Th1 Memory Cell Development in P. Chabaudi Malaria
    Robin Stephens; Fiscal Year: 2013
    ..same techniques I used in my dissertation work, and secondly;to study the indicative pattern of cytokines, cytokine receptors, transcription and chromatin tatistics factors to define mechanisms utilized by Th1 memory cells for ..
  36. Effect of HIV Infection and HAART on Bone Homeostasis
    MERVYN NEALE WEITZMANN; Fiscal Year: 2013
    ..This proposal will investigate how HIV-induced perturbations in B cell function drives bone loss in HIV/AIDS, and examine the effects of different HAART formulations on this process, in animals and humans. ..
  37. Therapeutic vaccines for treatment of experimental autoimmune encephalomyelitis (
    Mark D Mannie; Fiscal Year: 2011
    ..effector T cells and whether the cytokine domains of TTV require specific interactions with the respective cytokine receptors in vivo to elicit tolerance...
  38. Mechanisms of tumor resistance to anti-HER/ErbB therapeutics
    Zhen Fan; Fiscal Year: 2012
    ..We will investigate this possibility. Our findings may indicate that EPO should not be administered to breast cancer patients who are being treated with trastuzumab. ..
  39. The role of the atypical PKCs in osteoclast function
    JULIA THERESE WARREN; Fiscal Year: 2013
    ..We propose to study the mechanisms by which the osteoclast, the sole bone resorbing cell, functions. This will help provide the foundations for novel therapeutic development to treat osteoporosis. ..
  40. Obesity and Allergic Airway Hyperresponsiveness
    RICHARD ALAN JOHNSTON; Fiscal Year: 2013
    ..which is characterized by increased serum concentrations of hormones, cytokines, chemokines, and soluble cytokine receptors. These substances, collectively termed adipokines, are largely pro-inflammatory in nature...
  41. The non-canonical NF-kappaB pathway in survival and function of T lymphocytes
    David C Parker; Fiscal Year: 2013
    ..of these TNFR family members is necessary for induction and maintenance of expression of the cytokines, cytokine receptors, and anti-apoptotic proteins that allow T cells to survive and function as differentiated effector and ..
  42. Pro & Anti-Inflammatory Cytokines in Colorectal Cancer
    GLORIA YF HO; Fiscal Year: 2010
    ..Other cytokines and cytokine receptors, such as soluble TNF receptor types I and II (sTNF-R1 and sTNF-R2), IL-1 receptor antagonist (IL-1Ra), and ..
    Peter F Weller; Fiscal Year: 2013
    ..bodies and whether lipid body localized cytokines function locally within lipid bodies by signaling via cytokine receptors present within lipid bodies...
  44. Image-guided combination therapy: noninvasive assessment of delivery and response
    Susanta K Sarkar; Fiscal Year: 2013
    ..of tyrosine- kinase receptors represent a more potent approach as they inhibit functions of multiple cytokine receptors and have better delivery properties compared to monoclonal antibodies (mAb)...
  45. Dendritic Cells, Rapamycin and Transplant Tolerance
    Angus W Thomson; Fiscal Year: 2010
    ..We will assess how RAPA affects signaling via Toll and cytokine receptors to maximize their tolerogenic potential;in AIM II, we will determine the optimal protocol for induction of ..
  46. A Novel Mouse Model of Temporal Lobe Epilepsy
    Karen S Wilcox; Fiscal Year: 2013
    ..Preliminary data using C57BL/6 mice with various cytokines or cytokine receptors knocked-out have shown that these genetic manipulations can significantly alter the pathologic sequelae ..
    Mark R Boothby; Fiscal Year: 2010
    ..question of general and fundamental significance about the rules which govern how selectivity is achieved by cytokine receptors in activating specific Stat transcription factors...
  48. Transmembrane Regulation of Ectodomain Shedding
    Renhao Li; Fiscal Year: 2012
    ..from the host cell, affects a variety of biologically important proteins including growth factor precursors, cytokine receptors, amyloid precursor proteins and cell adhesion receptors, and proteoglycans...
  49. Repressor-PPAR Interactions in Inflammation and Atherosclerosis
    Grant D Barish; Fiscal Year: 2013
    ..Work over the past two decades has identified pathways initiated through cell surface toll-like and cytokine receptors which culminate in the activation of NF-kB, AP1, and Stat proteins and subsequent transcriptional activation ..
  50. Non-Toll-like receptor innate immune signaling
    David M Underhill; Fiscal Year: 2012
    ..In Aim 3 we will define the effect of the role of Dectin-1 and NFAT signaling in innate and adaptive immune responses in vivo. ..
  51. Targeting IL-12/23 p40 Pathways for the Control of GVHD
    Xue Zhong Yu; Fiscal Year: 2013
  52. Gene Therapy for SCID-X1 using a self-inactivating (SIN) gammaretroviral vector
    David A Williams; Fiscal Year: 2013
    ..This study will prove whether a safer gene therapy design will be effective without causing leukemia. ..
  53. Regulation of hematopoietic stem cell and progenitor cell proliferation by Runx1
    NANCY ASMUSSEN SPECK; Fiscal Year: 2013
    ..8 to 36.3/100,000 after the age 70 years. There are currently 35,000 to 55,000 MDS cases in the United States. Understanding the molecular basis of this disease may enable us to find new drug targets. ..
  54. Opioid Impact on Trim37-Induced Restriction of HIV
    LAUREN BRITTANY BEACH; Fiscal Year: 2013
    ..Given that many of the 33.4 million HIV-1 infected people worldwide use opioids, these studies have the potential to improve global human health among HIV-1 infected opioid users. ..
  55. Stat3 Isoforms in Maturation and Survival of Normal and Malignant Myeloid Cells
    Michele S Redell; Fiscal Year: 2012
    ..applicant): Signal transducer and activator of transcription 3 (StatS) is a key signaling intermediate for cytokine receptors that regulate the survival, proliferation, and differentiation of myeloid progenitor cells...
    FRANCOIS J VILLINGER; Fiscal Year: 2013
    ..2. Characterization and in vivo testing of soluble cytokine receptors as immune modulatory enhancers. 3...
  57. Signals Affecting Homestasis and Tolerance in Memory T Cells
    Jonathan S Maltzman; Fiscal Year: 2013
    ..processes are controlled via extracellular signals recognized by the clonotypic T cell receptor (TCR) and cytokine receptors. The relative contribution of TCR signals and cytokine receptor generated signals may vary depending on the ..
  58. Innate Immune Defense against Clostridium Difficile Infection
    Eric G Pamer; Fiscal Year: 2013
    ..difficile infection and to discover practicable approaches, such as selective TLR or cytokine receptor stimulation or microbiota manipulation, to re-induce these mechanisms in vulnerable patients. ..
  59. Therapeutic Application of Small Molecule MIF Inhibitors in Rheumatoid Arthritis
    Yoonsang Cho; Fiscal Year: 2013
    ..To date, three MIF receptors have been reported: 1) an invariant chain CD74, and CXC cytokine receptors 2) CXCR2 and 3) CXCR4...
  60. Host Genetics of HIV-1 Subtype C Infection, Progression, and Treatment in Africa
    Myron E Essex; Fiscal Year: 2010
    ..factors, mitochondria! genes, selected immune response modifiers and HIV-1 co-receptors (cytokines and cytokine receptors, chemokines and chemokine receptors), HLA class 1 genes and host factors required for HIV-1 life cycle on: 1)..
  61. Regulation of neutrophil function and inflammation by ADAM17 during infection
    Bruce K Walcheck; Fiscal Year: 2010
    ..shedding directs both instantaneous and prolonged alterations in the activity of various cytokines, cytokine receptors, and adhesion molecules...
  62. Control of Treg Homeostasis and Function by the Lipid Phosphatase PTEN
    Laurence A Turka; Fiscal Year: 2013
    ..Our studies will yield new insights into Treg signaling pathways and provide potential therapeutic strategies to enhance immune tolerance. ..
  63. Phase II, IL-1 Trap for Treatment of Familial Mediterranean Fever
    Steven J Spalding; Fiscal Year: 2010
    ..In the long- term, better FMF control may prevent amyloidosis. This study may confirm the importance of IL-1 in the pathogenesis of FMF and provide support for an FDA filing for use of IL-1 Trap in FMF. ..
    Gerald Davis; Fiscal Year: 2003
    ..And other interstitial lung diseases where the cause is not known and treatment is not effective. ..
  65. Tyrosine Phosphyorylation and Growth Hormone Signaling
    STUART FRANK; Fiscal Year: 2005
    Growth hormone (GH) and prolactin (PRL) interact with GH and prolactin receptors (GHR; PRLR), both cytokine receptors, causing activation of the GHR- and PRLR-associated tyrosine kinase, JAK2, and the STATS and ERK pathways...
    Steven Moss; Fiscal Year: 2009
    ..We propose to evaluate a new mouse model of H. pylori-induced gastric cancer that we have developed, in order to address these important questions. ..
    MARIBETH RAINES; Fiscal Year: 1999
    ..Preliminary data from the PI suggest that sGMR-alpha may function differently from other soluble cytokine receptors in that it may associate with the signal transducing component of the GM-CSF receptor (betac) on the cell ..
  68. NF-kappaB Regulation by Androgen Receptor
    ALBERT BALDWIN JR; Fiscal Year: 2004
    ..the immune and inflammatory response through its ability to control expression of genes encoding cytokines, cytokine receptors, and chemokines...
  69. Signal Transduction by Cytokine Receptors in Vivo
    Warner Greene; Fiscal Year: 2004
    ..Much remains to be learned about signal transduction specificity by these cytokine receptors. For example: 1)...
    Steven Anderson; Fiscal Year: 2001
    ..It is hypothesized that Src-like kinases are required for mitogenic stimulation by cytokine receptors and, furthermore, that activation of the kinases is regulated by the binding of their SH2 domains to a ..
  71. Erythropoietin receptor /Janus Kinase 2 complex
    Lily Huang; Fiscal Year: 2006
    ..Unfortunately, little information is known about the structures of the cytoplasmic domain of any cytokine receptors, JAKs, or their complexes. This fellowship will probe the molecular structure of the EpoR/JAK2 complex...
  72. Gene Therapy for Purine Nucleoside Phosphorylase Deficiency (PNP)
    Kevin Baker; Fiscal Year: 2007
    ..SCID), in which bone marrow cells from children deficient in the common gamma-chain for several cytokine receptors were exposed to a retrovirus encoding the missing gene and then reinfused into the patient...
    Douglas Fearon; Fiscal Year: 2006
    ..abstract_text> ..
  74. Identification of Biofilm-Induced Staphylococcus aureus Cytokine Receptors
    ARLENE HOOGEWERF; Fiscal Year: 2006
    ..Third, we will study the regulation of the cytokine receptors, and determine the contribution of biofilm cytokine binding to the increased evasion of host cellular ..
    Louise Showe; Fiscal Year: 2001
    ..An understanding of the genetic events that lead to tachyphylaxis could provide clues to alternate interim therapies that might reinduce IL-12 responsiveness. ..
    JOAN HUNT; Fiscal Year: 1999
    ..of light chains, peptide transporters (TAP-1, TAP-2), proteasome components (LMP2, LMP7), cytokines and cytokine receptors may uniquely govern HLA class I expression in trophoblast cells...
    Jonathan Drachman; Fiscal Year: 2000
    ..A better understanding of the mechanisms which underlie megakaryocytic development is a necessary prerequisite to providing new therapeutic options for patients with hematopoietic disorders. ..
    Warner Greene; Fiscal Year: 1999
    ..appear to play a major role in growth signaling and both are members of a new and burgeoning super-family of cytokine receptors. The highly inducible and transient nature of alpha gene expression likely plays a central role in governing ..
  79. IL-7R and c-kit interactions in thymopoiesis
    Kenneth Weinberg; Fiscal Year: 2006
    ..abstract_text> ..