Genomes and Genes
macrophage 1 antigen
Summary: An adhesion-promoting leukocyte surface membrane heterodimer. The alpha subunit consists of the CD11b ANTIGEN and the beta subunit the CD18 ANTIGEN. The antigen, which is an integrin, functions both as a receptor for complement 3 and in cell-cell and cell-substrate adhesive interactions.
Publications178 found, 100 shown here
- Relative contribution of LFA-1 and Mac-1 to neutrophil adhesion and migrationZ M Ding
Speros P Martel Laboratory of Leukocyte Biology, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA
J Immunol 163:5029-38. 1999..Neutrophil extravasation in response to TNF-alpha in LFA-1-deficient mice dramatically decreased, whereas neutrophil extravasation in Mac-1-deficient mice markedly increased...
- Crystal structure of the A domain from the alpha subunit of integrin CR3 (CD11b/CD18)J O Lee
Laboratory of X ray Crystallography, Dana Farber Cancer Institute, Harvard Medical School Boston, Massachusetts 02115
Cell 80:631-8. 1995..Our crystal structure will allow reliable models to be built for other members of the A domain superfamily and should facilitate development of novel adhesion modulatory drugs...
- Characterization of the receptor-ligand pathways important for entry and survival of Francisella tularensis in human macrophagesAshwin Balagopal
Department of Internal Medicine, Ohio State University, 420 W 12th Avenue, 216 Tzagournis Medical Research Facility, Columbus, OH 43210, USA
Infect Immun 74:5114-25. 2006..This study demonstrates that human macrophages phagocytose more Francisella than monocytes with contributions from CR3, Fcgamma receptors, the MR, and SP-A present in lung alveoli...
- Leukocyte engagement of fibrin(ogen) via the integrin receptor alphaMbeta2/Mac-1 is critical for host inflammatory response in vivoMatthew J Flick
Children s Hospital Research Foundation and the University of Cincinnati College of Medicine, Cincinnati, Ohio 45229 3039, USA
J Clin Invest 113:1596-606. 2004....
- Dectin-1 is a major beta-glucan receptor on macrophagesGordon D Brown
Sir William Dunn School of Pathology, University of Oxford, United Kingdom
J Exp Med 196:407-12. 2002..Furthermore, these results identify Dectin-1 as a new target for examining the immunomodulatory properties of beta-glucans for therapeutic drug design...
- A subpopulation of Mac-1 (CD11b/CD18) molecules mediates neutrophil adhesion to ICAM-1 and fibrinogenM S Diamond
Committee on Cell and Developmental Biology, Harvard Medical School, Boston, Massachusetts
J Cell Biol 120:545-56. 1993..Because CBRM1/5 recognizes a fraction of Mac-1 on activated neutrophils, but still blocks Mac-1-dependent adhesion to fibrinogen and ICAM-1, we suggest that only a small subset of Mac-1 molecules is competent to mediate adhesion...
- Microglia and macrophage activation and the regulation of complement-receptor-3 (CR3/MAC-1)-mediated myelin phagocytosis in injury and diseaseShlomo Rotshenker
Department of Anatomy and Cell Biology, Hebrew University Hadassah Medical School and the Eric Roland Center for Neurodegenerative Diseases, POB 12272, Jerusalem 91120, Israel
J Mol Neurosci 21:65-72. 2003..Monoclonal antibody-induced phagocytosis regulation must reveal a mechanism by which native extracellular molecules bind to and regulate CR3/MAC-1-mediated myelin phagocytosis in microglia and macrophages...
- Complement c3a and c5a induce different signal transduction cascades in endothelial cellsIngrid U Schraufstatter
Department of Cancer Biology, La Jolla Institute for Molecular Medicine, San Diego, CA 92121, USA
J Immunol 169:2102-10. 2002..The C5aR in endothelial cells thus uses a signaling cascade-transactivation of the EGFR-that does not exist in leukocytes, while the C3aR couples to a different G protein, presumably G(alpha12/13)...
- Mice deficient in Mac-1 (CD11b/CD18) are less susceptible to cerebral ischemia/reperfusion injuryS G Soriano
Department of Anesthesia, Children s Hospital, Boston, MA 02115, USA
Stroke 30:134-9. 1999..To determine the role of Mac-1 during ischemia and reperfusion in the brain, we analyzed the effect of transient focal cerebral ischemia in mice genetically engineered with a specific deficiency in Mac-1...
- The human S100 protein MRP-14 is a novel activator of the beta 2 integrin Mac-1 on neutrophilsR A Newton
Leukocyte Adhesion Laboratory, Imperial Cancer Research Fund, London, United Kingdom
J Immunol 160:1427-35. 1998..We postulate that MRP-14 and MRP-8 are important in vivo candidates for the regulated adhesion of neutrophils through control of Mac-1 activity...
- Sequence gamma 377-395(P2), but not gamma 190-202(P1), is the binding site for the alpha MI-domain of integrin alpha M beta 2 in the gamma C-domain of fibrinogenTatiana P Ugarova
Joseph J Jacobs Center for Thrombosis and Vascular Biology, Department of Molecular Cardiology, Lerner Research Institute, Cleveland, Ohio 44195, USA
Biochemistry 42:9365-73. 2003..Thus, these data demonstrate the essential role of the P2, but not P1, sequence for binding of gamma C by the alpha(M)I-domain and suggest that the adhesive function of P2 depends on the minimal recognition motif NRLTIG...
- Identification of a novel recognition sequence for integrin alphaM beta2 within the gamma-chain of fibrinogenT P Ugarova
Joseph J Jacobs Center for Thrombosis and Vascular Biology, Department of Molecular Cardiology, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
J Biol Chem 273:22519-27. 1998..The juxtapositioning of these two sequences may form an unique and complex binding site for alphaM beta2...
- Bacterial phagocytosis activates extracellular signal-regulated kinase and p38 mitogen-activated protein kinase cascades in human neutrophilsK R McLeish
Department of Medicine, University of Louisville Health Sciences Center, Veterans Affairs Medical Center, Kentucky, USA
J Leukoc Biol 64:835-44. 1998..In conclusion, bacterial phagocytosis stimulates ERK and p38 activation by distinct signal transduction pathways. Phagocytosis-stimulated p38 kinase activity is necessary for optimal H2O2 production...
- Impaired mast cell development and innate immunity in Mac-1 (CD11b/CD18, CR3)-deficient miceA R Rosenkranz
Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
J Immunol 161:6463-7. 1998....
- Utilization of CD11b knockout mice to characterize the role of complement receptor 3 (CR3, CD11b/CD18) in the growth of Mycobacterium tuberculosis in macrophagesM D Melo
Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada
Cell Immunol 205:13-23. 2000..However, whether a mycobacterium will gain access to the intracellular environment, and the type of Mφ that the bacterium enters, is significantly affected by the presence or absence of CR3...
- Intraluminal crawling of neutrophils to emigration sites: a molecularly distinct process from adhesion in the recruitment cascadeMia Phillipson
Immunology Research Group, Department of Physiology and Biophysics, University of Calgary, Calgary T2N 4N1, Alberta, Canada
J Exp Med 203:2569-75. 2006..e., LFA-1-dependent adhesion followed by Mac-1-dependent crawling, and both steps ultimately contribute to efficient emigration out of the vasculature...
- Leukocyte integrin Mac-1 recruits toll/interleukin-1 receptor superfamily signaling intermediates to modulate NF-kappaB activityC Shi
Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
Circ Res 89:859-65. 2001..Taken together, these observations indicate that Mac-1 recruits a Toll/IL-1 receptor family-like cascade to modulate NF-kappaB activity. This represents a new pathway for integrin-dependent modulation of gene expression...
- Delineation of the key amino acids involved in neutrophil inhibitory factor binding to the I-domain supports a mosaic model for the capacity of integrin alphaMbeta 2 to recognize multiple ligandsValentin A Ustinov
Joseph J Jacobs Center for Thrombosis and Vascular Biology, and Department of Molecular Cardiology NB50, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
J Biol Chem 277:18769-76. 2002..Thus, the alpha(M)I-domain appears to present a mosaic of exposed amino acids within surface loops on its MIDAS face, and different ligands interact with different residues to attain high affinity binding...
- A novel role for the beta 2 integrin CD11b/CD18 in neutrophil apoptosis: a homeostatic mechanism in inflammationA Coxon
Department of Pathology, Brigham and Women s Hospital, Boston, Massachusetts, USA
Immunity 5:653-66. 1996..Thus, CD11b/CD18 plays a novel and unsuspected homeostatic role in inflammation by accelerating the programmed elimination of extravasated neutrophils...
- A peptide derived from the intercellular adhesion molecule-2 regulates the avidity of the leukocyte integrins CD11b/CD18 and CD11c/CD18R Li
Department of Biochemistry, University of Helsinki, Finland
J Cell Biol 129:1143-53. 1995..These findings indicate that in addition to induction of CD11a/CD18-mediated cell adhesion, the ICAM-2 peptide may also serve as a "trigger" for high avidity ligand binding of other beta 2 integrins...
- A role for Mac-1 (CDIIb/CD18) in immune complex-stimulated neutrophil function in vivo: Mac-1 deficiency abrogates sustained Fcgamma receptor-dependent neutrophil adhesion and complement-dependent proteinuria in acute glomerulonephritisT Tang
Department of Pathology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
J Exp Med 186:1853-63. 1997..Since Mac-1 on PMNs is the principal ligand for ic3b, an absence of Mac-1 interaction with C3 probably contributed to the abrogation of proteinuria in Mac-1-null mice...
- Soluble beta-glucan polysaccharide binding to the lectin site of neutrophil or natural killer cell complement receptor type 3 (CD11b/CD18) generates a primed state of the receptor capable of mediating cytotoxicity of iC3b-opsonized target cellsV Vetvicka
The Division of Experimental Immunology and Immunopathology, Departmentof Pathology, University of Louisville, Kentucky 40292, USA
J Clin Invest 98:50-61. 1996..These polysaccharides function through binding to phagocyte or NK cell CR3, priming the receptor for cytotoxicity of neoplastic tissues that are frequently targeted with iC3b and sparing normal tissues that lack iC3b...
- In vivo developmental stages in murine natural killer cell maturationSungjin Kim
Howard Hughes Medical Institute and Rheumatology Division, Department of Internal Medicine, Barnes Jewish Hospital and Washington University School of Medicine, St Louis, MO 63110, USA
Nat Immunol 3:523-8. 2002....
- Functional receptor for C3a anaphylatoxin is expressed by normal hematopoietic stem/progenitor cells, and C3a enhances their homing-related responses to SDF-1Ryan Reca
Stem Cell Biology Program, University of Louisville, Louisville, KY 40202, USA
Blood 101:3784-93. 2003..C3a is the first positive regulator of this axis to be identified...
- Reversal of proinflammatory responses by ligating the macrophage Fcgamma receptor type IF S Sutterwala
Department of Microbiology and Immunology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
J Exp Med 188:217-22. 1998..This reciprocal alteration in the pattern of macrophage cytokine production illustrates a potentially important role for FcgammaR-mediated clearance in suppressing macrophage proinflammatory responses...
- The junctional adhesion molecule 3 (JAM-3) on human platelets is a counterreceptor for the leukocyte integrin Mac-1Sentot Santoso
Institute for Clinical Immunology and Transfusion Medicine, Justus Liebig University, D 35385 Giessen, Germany
J Exp Med 196:679-91. 2002..JAM-3 thereby provides a novel molecular target for antagonizing interactions between vascular cells that promote inflammatory vascular pathologies such as in atherothrombosis...
- Differential infection of mononuclear phagocytes by Francisella tularensis: role of the macrophage mannose receptorGrant S Schulert
Inflammation Program and Department of Microbiology, University of Iowa, 2501 Crosspark Rd, Coralville, 52241, USA
J Leukoc Biol 80:563-71. 2006..Conversely, MDM used MR and CD11b/CD18 to ingest opsonized organisms. Altogether, our data demonstrate differential infection of mononuclear phagocytes by Ft and define distinct roles for MR and CR3 in phagocytosis...
- Shape and shift changes related to the function of leukocyte integrins LFA-1 and Mac-1N Hogg
Leukocyte Adhesion Laboratory, Imperial Cancer Research Fund, London, England, UK
J Leukoc Biol 69:893-8. 2001..Leukocytes use LFA-1 to migrate across the endothelium. Active beta1 integrins may be required subsequently to bind the matrix proteins encountered by leukocytes as they continue their voyage into the tissue interior...
- Regulation of phagocytosis by Rho GTPasesF Niedergang
Membrane and Cytoskeleton Dynamics Group, Institut Curie, CNRS UMR144, 75248 Paris, France
Curr Top Microbiol Immunol 291:43-60. 2005..As reviewed here, Rho family GTPases, their activators, and their downstream effectors control the local reorganization of the actin cytoskeleton beneath bound particles...
- Interactions between Mycobacterium tuberculosis and host cells: are mycobacterial sugars the key?M R Ehlers
BioNebraska Inc, Lincoln, NE 68524, USA
Trends Microbiol 6:328-35. 1998..Binding to specific receptors, such as complement receptor type 3, could provide an advantage. These interactions appear to involve surface polysaccharides and glycolipids...
- Two conformations of the integrin A-domain (I-domain): a pathway for activation?J O Lee
Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
Structure 3:1333-40. 1995....
- Mac-1 signaling via Src-family and Syk kinases results in elastase-dependent thrombohemorrhagic vasculopathyJunichi Hirahashi
Department of Pathology, Center for Excellence in Vascular Biology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Immunity 25:271-83. 2006..These data suggest that Mac-1 engagement of complement activates tyrosine kinases to promote elastase-dependent blood vessel injury in vivo...
- Cooperative interactions of LFA-1 and Mac-1 with intercellular adhesion molecule-1 in facilitating adherence and transendothelial migration of human neutrophils in vitroC W Smith
Speros P Martel Laboratory of Leukocyte Biology, Baylor College of Medicine, Houston, Texas 77054
J Clin Invest 83:2008-17. 1989..The results in this report indicate that unstimulated neutrophils exhibit LFA-1-dependent attachment to ICAM-1, and chemotactic stimulation enhances the attachment of human neutrophils to ICAM-1 by a Mac-1-dependent process...
- The beta-glucan-binding lectin site of mouse CR3 (CD11b/CD18) and its function in generating a primed state of the receptor that mediates cytotoxic activation in response to iC3b-opsonized target cellsY Xia
Division of Experimental Immunology and Immunopathology, Department of Pathology, University of Louisville, KY 40292, USA
J Immunol 162:2281-90. 1999..The similarity of mouse and human CR3 in response to beta-glucans highlights the utility of mouse tumor models for development of therapeutic beta-glucans...
- CD8alpha+ dendritic cells originate from the CD8alpha- dendritic cell subset by a maturation process involving CD8alpha, DEC-205, and CD24 up-regulationGloria Martinez del Hoyo
Department of Cell Biology, Faculty of Biology, Complutense University, 28040 Madrid, Spain
Blood 99:999-1004. 2002....
- Enteropathogenic Escherichia coli mediates antiphagocytosis through the inhibition of PI 3-kinase-dependent pathwaysJ Celli
Biotechnology Laboratory, University of British Columbia, Vancouver, BC, V6T 1Z3, Canada
EMBO J 20:1245-58. 2001..This constitutes a novel mechanism of phagocytosis avoidance by an extracellular pathogen...
- 7E3 monoclonal antibody directed against the platelet glycoprotein IIb/IIIa cross-reacts with the leukocyte integrin Mac-1 and blocks adhesion to fibrinogen and ICAM-1D I Simon
Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
Arterioscler Thromb Vasc Biol 17:528-35. 1997....
- Mac-1 (CD11b/CD18) mediates adherence-dependent hydrogen peroxide production by human and canine neutrophilsS B Shappell
Speros P Martel Leukocyte Biology Laboratory, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030
J Immunol 144:2702-11. 1990..These results indicate that Mac-1 (CD11b/CD18) can mediate adhesion-dependent H2O2 production by human and canine neutrophils exposed to chemotactic factors...
- Staphylococcus aureus extracellular adherence protein serves as anti-inflammatory factor by inhibiting the recruitment of host leukocytesTriantafyllos Chavakis
Institute for Biochemistry, Third Department of Internal Medicine, Justus Liebig Universitat, Giessen, Germany
Nat Med 8:687-93. 2002....
- Macrophage phagocytosis of myelin in vitro determined by flow cytometry: phagocytosis is mediated by CR3 and induces production of tumor necrosis factor-alpha and nitric oxideL J van der Laan
Department of Immunology and Cell Biology, Faculty of Medicine, Vrije Universiteit, Amsterdam, The Netherlands
J Neuroimmunol 70:145-52. 1996..Our results indicate an important role for CR3 in myelin phagocytosis. The induction of TNF-alpha and NO which accompanies this phagocytosis may further contribute to the overall process of demyelination during MS or EAE...
- Effects of IL-8, Gro-alpha, and LTB(4) on the adhesive kinetics of LFA-1 and Mac-1 on human neutrophilsS M Seo
Institute of Biosciences and Bioengineering, Rice University, Houston 77005, USA
Am J Physiol Cell Physiol 281:C1568-78. 2001..These kinetic and topographical differences may indicate distinct functional contributions of LFA-1 and Mac-1 on neutrophils...
- Transendothelial migration and trafficking of leukocytes in LFA-1-deficient miceD P Andrew
Amgen Inc, Boulder, USA
Eur J Immunol 28:1959-69. 1998..Finally, whereas anti-CD31 mAb blocked WT monocyte and neutrophil transendothelial cell migration they did not block LFA-1-deficient monocyte and neutrophil transendothelial migration...
- Modulation (inhibition and augmentation) of complement receptor-3-mediated myelin phagocytosisF Reichert
Department of Anatomy and Cell Biology, Hebrew University-Hadassah Medical School, Jerusalem, 91120, Israel
Neurobiol Dis 8:504-12. 2001....
- Regulated unmasking of the cryptic binding site for integrin alpha M beta 2 in the gamma C-domain of fibrinogenValeryi K Lishko
Joseph J Jacobs Center for Thrombosis and Vascular Biology, Department of Molecular Cardiology, Lerner Research Institute, Cleveland, Ohio 44195, USA
Biochemistry 41:12942-51. 2002....
- Mycobacterium tuberculosis-infected human macrophages exhibit enhanced cellular adhesion with increased expression of LFA-1 and ICAM-1 and reduced expression and/or function of complement receptors, FcgammaRII and the mannose receptorLucy E DesJardin
Veterans Admin Med Center and Depts of Medicine, Microbiology and the Interdisciplinary Immunology Program, University of Iowa, Iowa City, USA
Microbiology 148:3161-71. 2002....
- Glycosylation restores survival of chilled blood plateletsKarin M Hoffmeister
Division of Hematology, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Science 301:1531-4. 2003..Platelet-associated galactosyltransferase produces efficient galactosylation when uridine diphosphate-galactose is added, affording a potentially simple method for storing platelets in the cold...
- The adenylate cyclase toxin of Bordetella pertussis binds to target cells via the alpha(M)beta(2) integrin (CD11b/CD18)P Guermonprez
Unit of Biology of Immune Regulations, Institut Pasteur, Paris, France
J Exp Med 193:1035-44. 2001..Thus, the cellular distribution of CD11b, mostly on neutrophils, macrophages, and dendritic and natural killer cells, supports a role for CyaA in disrupting the early, innate antibacterial immune response...
- Galectin-3/MAC-2, Ras and PI3K activate complement receptor-3 and scavenger receptor-AI/II mediated myelin phagocytosis in microgliaShlomo Rotshenker
Department of Anatomy and Cell Biology, Hebrew University Faculty of Medicine, and The Eric Roland Center for Neurodegenerative Diseases, Jerusalem, Israel
Glia 56:1607-13. 2008..An explanation may thus be offered for deficient phagocytosis by microglia that express CR3/MAC-1 and SRAI/II without Galectin-3/MAC-2 and efficient phagocytosis when CR3/MAC-1 and SRAI/II are co-expressed with Galectin-3/MAC-2...
- Platelet glycoprotein ibalpha is a counterreceptor for the leukocyte integrin Mac-1 (CD11b/CD18)D I Simon
Cardiovascular Division, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
J Exp Med 192:193-204. 2000..These observations provide a molecular target for disrupting leukocyte-platelet complexes that promote vascular inflammation in thrombosis, atherosclerosis, and angioplasty-related restenosis...
- LFA-1 is sufficient in mediating neutrophil emigration in Mac-1-deficient miceH Lu
Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030, USA
J Clin Invest 99:1340-50. 1997..Our results demonstrate that Mac-1 plays a critical role in mediating binding of neutrophils to fibrinogen and neutrophil degranulation, but is not necessary for effective neutrophil emigration, which is more dependent upon LFA-1...
- Uptake of serum-opsonized Francisella tularensis by macrophages can be mediated by class A scavenger receptorsLynda M Pierini
Department of Surgery, Weill Medical College of Cornell University, New York, NY 10021, USA
Cell Microbiol 8:1361-70. 2006..tularensis infection, namely, blocking SRA as a means of hindering F. tularensis access to its intracellular niche...
- Adenylate cyclase toxin subverts phagocyte function by RhoA inhibition and unproductive rufflingJana Kamanova
Cellular and Molecular Microbiology Division, Institute of Microbiology of the Academy of Sciences of the Czech Republic, Prague 4, Czech Republic
J Immunol 181:5587-97. 2008....
- Rho-kinase and myosin-II control phagocytic cup formation during CR, but not FcgammaR, phagocytosisIsabel M Olazabal
School of Biosciences, University of Birmingham, Edgbaston, B15 2TT, Birmingham, United Kingdom
Curr Biol 12:1413-18. 2002..While myosins have been previously implicated in FcgammaR phagocytosis, to our knowledge, this is the first demonstration of a role for myosin-II in CR phagocytosis...
- In vivo blood monocyte migration to acute inflammatory reactions, IL-1 alpha, TNF-alpha, IFN-gamma, and C5a utilizes LFA-1, Mac-1, and VLA-4. The relative importance of each integrinT B Issekutz
Department of Medicine, University of Toronto, Ontario, Canada
J Immunol 154:6533-40. 1995..4) The initiating inflammatory stimulus also modifies monocyte integrin usage, supporting the multistep combinatorial model of leukocyte extravasation...
- Decreased neointimal formation in Mac-1(-/-) mice reveals a role for inflammation in vascular repair after angioplastyD I Simon
Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
J Clin Invest 105:293-300. 2000..These data establish a role for inflammation in neointimal thickening and suggest that leukocyte recruitment to mechanically injured arteries may prevent restenosis...
- Tumor cell-derived prostaglandin E2 inhibits monocyte function by interfering with CCR5 and Mac-1R Zeidler
Department of Otolaryngology, University of Munich, 81377 Munich, Germany
FASEB J 14:661-8. 2000..Since both dysfunctions can be restored with NSAIDs, our findings help to explain the molecular chemopreventive action of NSAIDs on tumor formation and progression...
- A role for mammalian diaphanous-related formins in complement receptor (CR3)-mediated phagocytosis in macrophagesEmma Colucci-Guyon
Membrane and Cytoskeleton Dynamics Group, Unite Mixte de Recherche 144, Centre National de la Recherche Scientifique Institut Curie, 75248 Paris, France
Curr Biol 15:2007-12. 2005..These results indicate a new function for mDia proteins in the regulation of actin polymerization during CR3-mediated phagocytosis...
- An essential role for talin during alpha(M)beta(2)-mediated phagocytosisJenson Lim
Centre for Molecular Microbiology and Infection, Division of Cell and Molecular Biology, Imperial College London, London SW7 2AZ, United Kingdom
Mol Biol Cell 18:976-85. 2007..Our results establish for the first time at least two distinct roles for talin during CR3/alpha(M)beta(2)-mediated phagocytosis, most noticeably activation of the CR3/alpha(M)beta(2) receptor and phagocytic uptake...
- Regulation of CD11b/CD18 (Mac-1) adhesion to fibrinogen by urokinase receptor (uPAR)H Zhang
The Sol Sherry Thrombosis Research Center, Temple University School of Medicine, 3400 North Broad Street, Philadelphia, PA 19140, USA
Inflamm Res 52:86-93. 2003..The goal of this study is to investigate the consequence of the interaction between Mac-1 and uPAR and determine the mechanisms by which uPAR regulates Mac-1 dependent adhesion to fibrinogen...
- Nitric oxide has a role in regulating VLA-4-integrin expression on the human neutrophil cell surfaceNicola Conran
Department of Pharmacology, FCM, UNICAMP, Campinas, Brazil
Biochem Pharmacol 66:43-50. 2003....
- Complement receptor 3 (CD11b/CD18) mediates type I and type II phagocytosis during nonopsonic and opsonic phagocytosis, respectivelyVéronique Le Cabec
Institut de Pharmacologie et de Biologie Structurale, Centre National de la Recherche Scientifique, Toulouse, France
J Immunol 169:2003-9. 2002..Therefore, CR3 mediates type I phagocytosis under nonopsonic conditions and type II under opsonic conditions. This is the first evidence that a single receptor can mediate both types of phagocytosis depending on the ligand used...
- Molecular definition of the bovine granulocytopathy syndrome: identification of deficiency of the Mac-1 (CD11b/CD18) glycoproteinM E Kehrli
National Animal Disease Center, USDA Agricultural Research Service, Ames, Iowa 50010
Am J Vet Res 51:1826-36. 1990..Bone marrow examination revealed diffuse myeloid hyperplasia, but no other abnormalities...
- A novel divalent cation-binding site in the A domain of the beta 2 integrin CR3 (CD11b/CD18) is essential for ligand bindingM Michishita
Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Charlestown 02129
Cell 72:857-67. 1993....
- Fibrinogen activates NF-kappa B transcription factors in mononuclear phagocytesR G Sitrin
Department of Internal Medicine, University of Michigan, Ann Arbor 48109, USA
J Immunol 161:1462-70. 1998..We conclude that contact with fibrinogen-derived proteins may contribute to mononuclear phagocyte activation by signaling through CD11b/CD18, resulting in selective activation of transcriptional regulatory factors, including NF-kappa B...
- Specific activation of leukocyte beta2 integrins lymphocyte function-associated antigen-1 and Mac-1 by chemokines mediated by distinct pathways via the alpha subunit cytoplasmic domainsK S Weber
Institut für Prophylaxe der Kreislaufkrankheiten, Ludwig Maximilians Universitat, D 80336 MUnchen, Germany
Mol Biol Cell 10:861-73. 1999..Our data suggest that a specific regulation of beta2 integrin avidity by chemokines may be important in leukocyte extravasation and may be triggered by distinct activation pathways transduced via the alpha subunit cytoplasmic domains...
- Transfer of type II collagen-induced arthritis from DBA/1 to severe combined immunodeficiency mice can be prevented by blockade of Mac-1P C Taylor
Kennedy Institute of Rheumatology, London, UK
Immunology 88:315-21. 1996..Our findings support the hypothesis that cells expressing Mac-1 play an important role in the induction and maintenance of joint damage in collagen-induced arthritis...
- Fibrin(ogen)-alpha M beta 2 interactions regulate leukocyte function and innate immunity in vivoMatthew J Flick
Children s Hospital Research Foundation and the University of Cincinnati College of Medicine, Cincinnati, OH 45229 3039, USA
Exp Biol Med (Maywood) 229:1105-10. 2004..Finally, the Fib gamma(390-396A) mice represent a valuable system for better defining the contribution of fibrin(ogen) to the inflammatory response in the absence of any confounding alteration in clotting function...
- Identification and reconstruction of the binding site within alphaMbeta2 for a specific and high affinity ligand, NIFL Zhang
Joseph J Jacobs Center for Thrombosis and Vascular Biology, Department of Molecular Cardiology, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
J Biol Chem 272:17558-64. 1997..Verifying this localization, when these segments were introduced into the alphaXI-domain, the resulting chimeric receptor was converted into a high affinity NIF-binding protein...
- Regulation of leukocyte recruitment by polypeptides derived from high molecular weight kininogenT Chavakis
Institute for Biochemistry, and, Third Department of Internal Medicine, Justus Liebig Universitat, Giessen, Germany
FASEB J 15:2365-76. 2001....
- Identification of the binding site for fibrinogen recognition peptide gamma 383-395 within the alpha(M)I-domain of integrin alpha(M)beta2V P Yakubenko
Joseph J. Jacobs Center for Thrombosis and Vascular Biology and the Department of Molecular Cardiology, Lerner Research Institute, Cleveland, Ohio 44195, USA
J Biol Chem 276:13995-4003. 2001....
- Complement-receptor-3 and scavenger-receptor-AI/II mediated myelin phagocytosis in microglia and macrophagesFanny Reichert
Department of Anatomy and Cell Biology, Hebrew University Hadassah Medical School and the Eric Roland Center for Neurodegenerative Diseases, Jerusalem 91120, Israel
Neurobiol Dis 12:65-72. 2003..We further document SRAI/II mediated myelin phagocytosis in microglia and CR3/MAC-1 contributing to myelin phagocytosis two- to threefold more than SRAI/II when the two receptors function together...
- Integrin engagement regulates monocyte differentiation through the forkhead transcription factor Foxp1Can Shi
Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
J Clin Invest 114:408-18. 2004..This represents a new pathway for integrin-dependent modulation of gene expression and control of cellular differentiation...
- ICAM-1-dependent pathways regulate colonic eosinophilic inflammationElizabeth Forbes
Allergy and Inflammation Research Group, Division of Biochemistry and Molecular Biology, The John Curtin School of Medical Research, Australian National University, Canberra, Australia
J Leukoc Biol 80:330-41. 2006..These studies demonstrate that beta2 -integrin/ICAM-1-dependent pathways are integral to eosinophil recruitment into the colon during GI inflammation associated with colonic injury...
- A novel form of integrin dysfunction involving beta1, beta2, and beta3 integrinsAlison McDowall
Leukocyte Adhesion Laboratory, Cancer Research UK London Research Institute, Lincoln s Inn Fields Laboratories, London, United Kingdom
J Clin Invest 111:51-60. 2003....
- Changes in activation states of murine polymorphonuclear leukocytes (PMN) during inflammation: a comparison of bone marrow and peritoneal exudate PMNTakuya Itou
Department of Preventive Veterinary Medicine and Animal Health, Nihon University School of Veterinary Medicine, Nihon University, 1866 Kameino, Fujisawa, Kanagawa 252 8510, Japan
Clin Vaccine Immunol 13:575-83. 2006..These results have major implications for murine neutrophil research and show the importance of defining which PMN subsets to use when investigating murine models...
- CR3 (CD11b/CD18) is the major macrophage receptor for IgM antibody-mediated phagocytosis of African trypanosomes: diverse effect on subsequent synthesis of tumor necrosis factor alpha and nitric oxideWanling Pan
Department of Veterinary Microbiology, Western College of Veterinary Medicine, University of Saskatchewan, 52 Campus Drive, Saskatoon, SK S7N 5B4, Canada
Microbes Infect 8:1209-18. 2006..congolense enhances synthesis of disease-producing TNF-alpha and inhibits synthesis of parasite-controlling NO. We suggest that signaling of inhibition of NO synthesis is mediated via CR3...
- Hypercapnic acidosis attenuates endotoxin-induced nuclear factor-[kappa]B activationKei Takeshita
Department of Medicine, School of Medicine, Keio University, Tokyo, Japan
Am J Respir Cell Mol Biol 29:124-32. 2003....
- Recruitment of Chlamydia pneumoniae-infected macrophages to the carotid artery wall in noninfected, nonatherosclerotic miceAndreas E May
Deutsches Herzzentrum und 1 Medizinische Klinik, Klinikum rechts der Isar, Germany
Arterioscler Thromb Vasc Biol 23:789-94. 2003..However, the role of C pneumoniae for monocyte recruitment is unknown. The aim of this study was to examine the impact of C pneumoniae on monocyte adhesion and migration...
- Proinflammatory activities of S100: proteins S100A8, S100A9, and S100A8/A9 induce neutrophil chemotaxis and adhesionCarle Ryckman
Infectious Diseases Research Center, Laval University Hospital Center, Sainte Foy, Quebec, Canada
J Immunol 170:3233-42. 2003..These studies 1) show that S100A8, S100A9, and S100A8/A9 are potent stimulators of neutrophils and 2) strongly suggest that these proteins are involved in neutrophil migration to inflammatory sites...
- Downregulation of mac-1 expression in monocytes by surface-bound IgGP X Fernández-Calotti
Laboratorio de Immunologia, IIHEMA, Academia Nacional de Medicina, Buenos Aires, Argentina
Scand J Immunol 57:35-44. 2003..However, there was no inhibition of TNF-alpha production induced by zymosan, suggesting that Mac-1-dependent responses require different levels of its expression to be fully activated...
- Distinct roles of Mac-1 and its counter-receptors in neonatal obstructive nephropathyB Lange-Sperandio
Department of Pediatrics, University of Heidelberg, Heidelberg, Germany
Kidney Int 69:81-8. 2006..ICAM-1 and its new ligands RAGE and JAM-C are sequentially activated in UUO. Blocking of Mac-1 and its ligands may confer synergistic renoprotective effects in neonatal obstructive nephropathy...
- CD44-mediated phagocytosis induces inside-out activation of complement receptor-3 in murine macrophagesEric Vachon
Division of Respirology, Department of Medicine, University of Toronto, Toronto, ON, Canada
Blood 110:4492-502. 2007..In addition, buffering of intracellular Ca(2+) did not affect CD44-mediated phagocytosis. Taken together, these data suggest that CD44 stimulation induces inside-out activation of CR3 through the GTPase Rap1...
- Mac-1, but not LFA-1, uses intercellular adhesion molecule-1 to mediate slow leukocyte rolling in TNF-alpha-induced inflammationJessica L Dunne
Department of Biomedical Engineering and Cardiovascular Research Center, University of Virginia Health Sciences Center, Charlottesville, VA 22908, USA
J Immunol 171:6105-11. 2003..However, blocking both Mac-1 and ICAM-1 had no greater effect than either blockade alone. We conclude that endothelial ICAM-1 is the main ligand responsible for slow leukocyte rolling mediated by Mac-1, but not LFA-1...
- Kinetics analysis of binding between melanoma cells and neutrophilsMeghan H Hoskins
Department of Bioengineering, The Pennsylvania State University, University Park, Pennsylvania 16802 6804, USA
Mol Cell Biomech 3:79-87. 2006....
- Impaired integrin-dependent function in Wiskott-Aldrich syndrome protein-deficient murine and human neutrophilsHong Zhang
Department of Laboratory Medicine, University of California, San Francisco, California 94143, USA
Immunity 25:285-95. 2006..These results suggest that impaired beta2 integrin function in WASp-deficient PMNs may contribute substantially to the clinical immunodeficiency suffered by WAS patients...
- Arteriogenesis proceeds via ICAM-1/Mac-1- mediated mechanismsImo E Hoefer
Research Group for Experimental and Clinical Arteriogenesis at the Department of Cardiology, University of Freiburg, Freiburg, Germany
Circ Res 94:1179-85. 2004....
- Human alloantibody anti-Mart interferes with Mac-1-dependent leukocyte adhesionUlrich J H Sachs
Institute for Clinical Immunology and Transfusion Medicine, Justus Liebig University, Giessen, Germany
Blood 104:727-34. 2004..In conclusion, some anti-Mart alloantibodies interfere with Mac-1-dependent cellular functions of neutrophils, cause NAIN, and may be used as tools for studying Mac-1-dependent functions...
- Bone marrow from CD18-/- (MAC-1-/-) homozygous deletion recombinant negative mice demonstrates increased longevity in long-term bone marrow culture and decreased contribution to irradiation pulmonary damageMichael W Epperly
Department of Radiation Oncology, University of Pittsburgh Cancer Institute, University of Pittsburgh Medical Center, PA 15213, USA
In Vivo 20:431-8. 2006..We sought to determine if this interaction affected the growth of marrow in long-term bone marrow cultures (LTBMCs) and macrophage migration to the irradiated lung in pulmonary fibrosis/organizing alveolitis...
- A novel pathway of HMGB1-mediated inflammatory cell recruitment that requires Mac-1-integrinValeria V Orlova
Experimental Immunology Branch, NCI, NIH, Bethesda, MD 20892, USA
EMBO J 26:1129-39. 2007..Together, a novel HMGB1-dependent pathway for inflammatory cell recruitment and activation that requires the functional interplay between Mac-1 and RAGE is described here...
- Neutrophils influence melanoma adhesion and migration under flow conditionsMargaret J Slattery
Department of Bioengineering and The Huck Institute for Life Sciences, The Pennsylvania State University, University Park, PA 16802, USA
Int J Cancer 106:713-22. 2003..These results suggest that transmigration of C8161 cells under flow conditions can be influenced by PMNs, mediated by Mac-1/ICAM-1 adhesive interactions and enhanced by altered cytokine production...
- Manifestations of inflammatory arthritis are critically dependent on LFA-1Gerald M Watts
Division of Rheumatology, Immunology, and Allergy, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
J Immunol 174:3668-75. 2005..Blocking mAbs further revealed an ongoing requirement for LFA-1 I-domain adhesive function in disease perpetuation. These findings suggest that the LFA-1 I-domain forms an attractive target for treatment of human inflammatory arthritis...
- Influence of CR3 (CD11b/CD18) expression on phagocytosis of Bordetella pertussis by human neutrophilsPaula S Mobberley-Schuman
Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati, 231 Albert Sabin Way, Cincinnati, OH 45267 0524, USA
Infect Immun 73:7317-23. 2005..These studies suggest that the activation and surface expression of CR3, FHA expression, and the efficiency of ACT internalization all influence whether B. pertussis will be phagocytosed and ultimately killed by neutrophils...
- Src family kinases mediate neutrophil adhesion to adherent plateletsVirgilio Evangelista
Laboratory of Vascular Biology and Pharmacology, Consorzio Mario Negri Sud, Via Nazionale 8 A, 66030 Santa Maria Imbaro, Italy
Blood 109:2461-9. 2007..These results definitely establish a role for SFKs in PMN recruitment by activated platelets and suggest novel targets to disrupt the pathophysiologic consequences of platelet-leukocyte interactions in vascular disease...
- Mac-1 (CD11b/CD18) as accessory molecule for Fc alpha R (CD89) binding of IgAAnnemiek B van Spriel
Immunotherapy Laboratory, Department of Immunology, University Medical Center, Medarex Europe, and Genmab, Utrecht, The Netherlands
J Immunol 169:3831-6. 2002..Binding studies showed the secretory component, by itself, to interact with Mac-1-expressing PMN, but not with Mac-1(-/-) PMN. These data demonstrate an essential role for Mac-1 in establishing SIgA-FcalphaRI interactions...
- Modulation of Mac-1 (CD11b/CD18)-mediated adhesion by the leukocyte-specific protein 1 is key to its role in neutrophil polarization and chemotaxisChunjie Wang
Cellular and Molecular Biology Division, Toronto Western Research Institute, Canada
J Immunol 169:415-23. 2002....
- Urokinase receptor-deficient mice have impaired neutrophil recruitment in response to pulmonary Pseudomonas aeruginosa infectionM R Gyetko
Pulmonary and Critical Care Medicine Division, Department of Internal Medicine, Ann Arbor Veterans Affairs Medical Center and University of Michigan Medical Center, Ann Arbor, MI 48109, USA
J Immunol 165:1513-9. 2000..aeruginosa. This is the first report of a requirement for uPAR during cellular recruitment in vivo against a clinically relevant pathogen...
- Peroxynitrite induces integrin-dependent adhesion of human neutrophils to endothelial cells via activation of the Raf-1/MEK/Erk pathwayC Zouki
Research Center, Maisonneuve-Rosemont Hospital and Department of Medicine, , , , Canada H1T 2M4
FASEB J 15:25-27. 2001....
- Dietary restriction impairs neutrophil exudation by reducing CD11b/CD18 expression and chemokine productionS Ikeda
Department of Surgery, Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan
Arch Surg 136:297-304. 2001..Even brief nutritional replenishment in diet-restricted patients may improve host defense via restoring these PMN functions and chemokine production at local inflammatory sites...
- [Study of the function of leukocyte adhesion molecules in chronic respiratory diseases]Yujie Chen
Department of Respiratory Medicine, The Fourth Hospital of Sichuan Province, Chengdu 610016, China
Zhonghua Jie He He Hu Xi Za Zhi 25:94-7. 2002..To study the function of leukocyte adhesion molecules in the pathogenesis of Chronic Obstructive Pulmonary Diseases (COPD) and cor pulmonale, and to evaluate the effect of anti-leukocyte-adhesion therapy for cor pulmonale...
- Kinetics of CD11b/CD18 up-regulation during infection with the agent of human granulocytic ehrlichiosis in miceDori L Borjesson
Center for Comparative Medicine, School of Medicine, University of California, Davis, California 95616, USA
Lab Invest 82:303-11. 2002..The data support crucial roles of CD11b/CD18 and IFN-gamma-mediated cell activation as mechanisms that limit bacterial replication...
- Opioid receptors on bone marrow neutrophils modulate chemotaxis and CD11b/CD18 expressionA Kulkarni-Narla
Department of Veterinary Pathobiology, University of Minnesota, 1988 Fitch Avenue, St. Paul, MN 55108-6010, USA
Eur J Pharmacol 414:289-94. 2001..The results indicate that kappa-opioid receptors expressed by neutrophils rapidly modulate chemotaxis and adhesion in vitro...
- Mac-1 (CR3) and Fc gamma receptors in immune-mediated neutrophil cytotoxicityTanya N Mayadas; Fiscal Year: 2013..This could lead to the identification of targeted therapeutic strategies that attenuate organ injury while minimally immunocompromising the host. ..
- Role of Eosinophils in Airway Inflammation and RemodelingNizar N Jarjour; Fiscal Year: 2013..Given the prominence of eosinophilic inflammation in a significant proportion of severe asthma patients, these advances will have direct implications for the patients most affected by this very common illness. ..
- Leukadherins as novel compounds for treating restenosisROBERTO IRENARDO VAZQUEZ PADRON; Fiscal Year: 2013..This will pave the way for the future discovery of novel therapeutic agents to treat restenosis after PCI as well as other vascular inflammatory diseases. ..
- CONTROL OF BLOOD ACTIVATION DURING OPEN HEART SURGERYL Edmunds; Fiscal Year: 2002..Because blood reactions during CPB and OHS are often mutually interdependent, we plan to study combinations of inhibitors that we believe will act synergistically. ..
- COMPLEMENT AND OPPORTUNISTIC MYCOBACTERIA IN AIDSMARCUS HORWITZ; Fiscal Year: 1990..Tuberculosis is correlated with CR1 and/or CR3 receptor number; f) Select mutant M. tuberculosis that do not fix C3 and determine if they are phagocytized by monocytes; g) Purify the M. tuberculosis C3-acceptor molecule(s)...
- BIACORE 3000 SURFACE PLASMON RESONANCE INSTRUMENTDudley Strickland; Fiscal Year: 2001..The availability of this instrument will greatly enhance the ability of these NIH-funded investigators to achieve their aims and will accelerate the development of knowledge required to better understand a variety of pathologies...
- The Urokinase-CD87 System in Macrophage ActivationRobert Sitrin; Fiscal Year: 2004....
- Lipid Raft Microdomains in Neutrophil FunctionROBERT GARY SITRIN; Fiscal Year: 2010..Hopefully, targeting the function of lipid raft microdomains will engender new therapeutic strategies for enhancing antimicrobial defenses and suppressing the deleterious effects of acute inflammation. ..
- Molecular Mechanisms That Regulate CD11d ExpressionJOHN NOTI; Fiscal Year: 2004..Transgenic analysis of the CD11d cis elements will be done to complement these studies. These studies will expand our understanding of normal myeloid development and leukemogenesis. ..
- Aging, CRH Stress Pathways and Atherogenic ProcessesLaura Redwine; Fiscal Year: 2002..This knowledge may ultimately contribute to the development of novel drug therapies. ..
- Tai Chi: Well-Being and Heart FailureLaura Redwine; Fiscal Year: 2007..Health education would be used as a control group rather than usual care to control for social interactions in the other two groups. [unreadable] [unreadable]..
- Mechanisms of Eosinophil AdhesionXiangdong Zhu; Fiscal Year: 2006..Knowledge of the signaling components required for eosinophil adhesion may provide insight into the pathogenesis of airway inflammation and lead to therapeutic interventions for human asthma. ..
- Erythropoietin receptors in breast cancerMURAT ARCASOY; Fiscal Year: 2008..abstract_text> ..
- Mechanisms of Disease Progression in EAERichard Jones; Fiscal Year: 2007..Aim 3 will evaluate the number and phenotype of regulatory T cells capable of blocking or reducing disease. [unreadable] [unreadable]..
- The Role of C3 and C3 receptors in Experimental Autoimmune EncephalomyelitisScott Barnum; Fiscal Year: 2007..These proposed studies will provide important new information with respect to the role of complement in demyelinating disease and point to potential therapeutic approaches for MS. ..
- Neutrophil-Mediated Melanoma Cell Adhesion and MigrationCheng Dong; Fiscal Year: 2006..Furthermore, since adhesion is a critical step in tumor metastasis these studies may identify novel therapeutic targets against invasive melanomas. [unreadable] [unreadable]..
- CD8 T cell response to vaccinia following lymphopeniaSTEPHEN JAMESON; Fiscal Year: 2006..Finally, in Aim #3, we will reverse the experimental system and ask whether bona fide memory T cells are able to participate in homeostatic proliferation and whether these ceils maintain their functional properties. ..
- CD8 T Lymphocyte Regulation of EAE Disease PhenotypeMichael Carrithers; Fiscal Year: 2008..unreadable] [unreadable]..
- Homeostatic Proliferation and Memory CD8 T CellsSTEPHEN JAMESON; Fiscal Year: 2007..abstract_text> ..
- Cell-mediated protection against pneumonic plagueSTEPHEN SMILEY; Fiscal Year: 2008..abstract_text> ..
- High Throughput Screen for Novel Inhibitors of Platelet Integrin alphaIIb-beta3Barry Coller; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- Neutrophil-macrophage Interactions Govern Liver ImmunityStephen H Gregory; Fiscal Year: 2010..Consequently, they should provide valuable insights that enable the development of innovative strategies to improve treatment and prevent the devastating consequencesoften associated with septicemia and sepsis. ..
- Improved Vaccines for Rift Valley Fever VirusMark T Heise; Fiscal Year: 2010....
- Multiscale modeling of leukocyte-tumor cell adhesion to endothelium in shear flowCheng Dong; Fiscal Year: 2010....
- TOGAVIRUS TROPISM FOR BONES, JOINTS, AND CNSMark T Heise; Fiscal Year: 2010....
- Role of gamma' Fibrinogen in Cardiovascular DiseaseDavid Farrell; Fiscal Year: 2006..2) To determine the relationship between fibrinogen isoforms and established cardiovascular disease risk factors. 3) To determine if the fibrinogen isoforms in plasma are independently associated with CVD. ..
- THE ROLE OF UROKINASE IN LUNG T LYMPHOCYTE RESPONSESMARGARET GYETKO; Fiscal Year: 2003..Determine if recombinant uPA can reverse the functional abnormalities in uPA minus/minus lymphocytes. ..
- Novel On-line Education in Protection of Human SubjectsBarry Coller; Fiscal Year: 2003..Questionnaires for researchers and data queries of the educational system will be designed to conduct research describing the impact of the training program on trainees and investigators. ..
- STATS in Bryostatin 1 induced differentiation of CLLTraci Battle; Fiscal Year: 2003..particularly when combined with other antileukemia drugs. ..
- Developmental regulation of CD8 class I MHC bindingSTEPHEN JAMESON; Fiscal Year: 2004..We will determine whether CD8beta plays a unique role in non-cognate Class I binding and in affecting the specific contact sites on the Class I MHC molecule to which CD8 binds. ..
- Priming CD4+ T cells to protect against pneumonic plagueSTEPHEN SMILEY; Fiscal Year: 2004..Our long-term goals are to use that information to develop effective pneuinonic plague vaccines. ..
- ROLE OF FIBRINOGEN IN FIBRINOLYSISDavid Farrell; Fiscal Year: 2004..The results from the experiments in this proposal should provide new knowledge about the process of fibrinolysis that may lead to ways of modulating fibrin clot stability and clot lysis in vivo. ..
- Non-Immunogenic Peptide AnticoagulantDavid Farrell; Fiscal Year: 2003..At the conclusion of these studies, essential milestones will be achieved for Phase II development of the gamma' peptide as a pharmacologic anticoagulant. ..
- LEUKOCYTE INTEGRIN ALPHA M BETA 2Edward Plow; Fiscal Year: 2004....
- THE STRUCTURE AND FUNCTION OF PLATELET GPIIB-IIIAEdward Plow; Fiscal Year: 2003..At the same time, these studies may have direct bearing on the use and future development of the GPIIb-IIIa blockers as antithrombotic agents. ..
- FRANCISELLA TULARENSIS: INNATE RESISTANCE TO IHALATIONStephen Gregory; Fiscal Year: 2004..abstract_text> ..
- Thrombospondins and AtherothrombosisEdward Plow; Fiscal Year: 2004..Together, these studies should provide a rigorous test of the hypothesis and extend our knowledge of the roles of the TSPs in cardiovascular biology. ..
- Roles for coagulation in immunitySTEPHEN SMILEY; Fiscal Year: 2005..Deciphering those mechanisms may lead to improved vaccines and/or treatments for pathologies characterized by fibrin deposition, including autoimmunity, allograft rejection, cancer and septic shock. ..
- MECHANISMS OF INFLAMMATORY LIVER INJURYC Smith; Fiscal Year: 2001..Specific Aim 4 will define the potential sources and function of soluble ICAM-1 in inflammatory liver injury. ..
- IN UTERO STEM CELL TRANSFER IN MPS VIIBrian Soper; Fiscal Year: 2005..abstract_text> ..
- Molecular Mechanisms in TCR Reactivity to Self LigandsSTEPHEN JAMESON; Fiscal Year: 2005..This has health implications for recovery of the T-cell pool in patients suffering from T lymphopenia due to disease (e.g. AIDS), or therapeutic treatments (such as bone morrow transplant). ..
- SIGNAL TRANSDUCTION AND MOTILITY IN TUMOR CELL MIGRATIONCheng Dong; Fiscal Year: 2002....
- EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS--INHIBITION OF CScott Barnum; Fiscal Year: 2002..These studies will also provide the basis for future work examining the potential for complement-inhibiting biological reagents as therapeutic adjuvants in MS. ..
- Conference on Central Nervous System InflammationScott Barnum; Fiscal Year: 2005..The meeting program is composed of a diverse group of investigators (over 45% are women, ethnic minorities or young investigators) and less than 40% of the program speakers receive NIH funding. ..
- 2004 Hemostasis Gordon Research ConferenceEdward Plow; Fiscal Year: 2004..The Hemostasis Gordon Conference has been a highly successful and enjoyable meeting, frequently identified as the best meeting attended by participants; and we believe that the current program has the potential to extend this tradition. ..
- Screening for Inhibitors of F. tularensis VirulenceLYNDA PIERINI; Fiscal Year: 2004..Small molecule modulators of F tularensis-macrophage interactions will be used in future experiments to identify virulence factors, and may provide leads for post-attack prophylaxes. ..
- CHARACTERIZATION AND TREATMENT OF MURINE MPS VIIBrian Soper; Fiscal Year: 2006..Differentiation capacity will be compared to directly brain implanted SC. Behavioral studies will determine long-term neurological function. ..
- Liver innate immunity in drug-induced liver diseaseZhang Xu Liu; Fiscal Year: 2006..Kaplowitz and the center members at the outstanding environment of USC Research Center for Liver Diseases. ..
- Arbovirus Evasion of Type I Interferon InductionMark Heise; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- Structural Basis of Novel Hookworm VaccinesOluwatoyin Asojo; Fiscal Year: 2006..56 Angstroms (protein data bank code 1U53). In addition, a 2 PR-1 domain ASP (Na-ASP-1) has been crystallized with data up to 2.7 Angstroms. [unreadable] [unreadable] [unreadable]..
- The Mechanism of IVIG Action in PemphigusZhi Liu; Fiscal Year: 2006..The overall goal of this project is to study the mechanisms of WIG action in autoantibody-mediated diseases and develop novel therapies to replace current immunosuppressive treatments, which confer severe side effects. ..