macrophage 1 antigen

Summary

Summary: An adhesion-promoting leukocyte surface membrane heterodimer. The alpha subunit consists of the CD11b ANTIGEN and the beta subunit the CD18 ANTIGEN. The antigen, which is an integrin, functions both as a receptor for complement 3 and in cell-cell and cell-substrate adhesive interactions.

Top Publications

  1. ncbi Relative contribution of LFA-1 and Mac-1 to neutrophil adhesion and migration
    Z M Ding
    Speros P Martel Laboratory of Leukocyte Biology, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA
    J Immunol 163:5029-38. 1999
  2. ncbi Crystal structure of the A domain from the alpha subunit of integrin CR3 (CD11b/CD18)
    J O Lee
    Laboratory of X ray Crystallography, Dana Farber Cancer Institute, Harvard Medical School Boston, Massachusetts 02115
    Cell 80:631-8. 1995
  3. pmc Characterization of the receptor-ligand pathways important for entry and survival of Francisella tularensis in human macrophages
    Ashwin Balagopal
    Department of Internal Medicine, Ohio State University, 420 W 12th Avenue, 216 Tzagournis Medical Research Facility, Columbus, OH 43210, USA
    Infect Immun 74:5114-25. 2006
  4. pmc Leukocyte engagement of fibrin(ogen) via the integrin receptor alphaMbeta2/Mac-1 is critical for host inflammatory response in vivo
    Matthew J Flick
    Children s Hospital Research Foundation and the University of Cincinnati College of Medicine, Cincinnati, Ohio 45229 3039, USA
    J Clin Invest 113:1596-606. 2004
  5. pmc Dectin-1 is a major beta-glucan receptor on macrophages
    Gordon D Brown
    Sir William Dunn School of Pathology, University of Oxford, United Kingdom
    J Exp Med 196:407-12. 2002
  6. pmc A subpopulation of Mac-1 (CD11b/CD18) molecules mediates neutrophil adhesion to ICAM-1 and fibrinogen
    M S Diamond
    Committee on Cell and Developmental Biology, Harvard Medical School, Boston, Massachusetts
    J Cell Biol 120:545-56. 1993
  7. ncbi Microglia and macrophage activation and the regulation of complement-receptor-3 (CR3/MAC-1)-mediated myelin phagocytosis in injury and disease
    Shlomo Rotshenker
    Department of Anatomy and Cell Biology, Hebrew University Hadassah Medical School and the Eric Roland Center for Neurodegenerative Diseases, POB 12272, Jerusalem 91120, Israel
    J Mol Neurosci 21:65-72. 2003
  8. ncbi Complement c3a and c5a induce different signal transduction cascades in endothelial cells
    Ingrid U Schraufstatter
    Department of Cancer Biology, La Jolla Institute for Molecular Medicine, San Diego, CA 92121, USA
    J Immunol 169:2102-10. 2002
  9. ncbi Mice deficient in Mac-1 (CD11b/CD18) are less susceptible to cerebral ischemia/reperfusion injury
    S G Soriano
    Department of Anesthesia, Children s Hospital, Boston, MA 02115, USA
    Stroke 30:134-9. 1999
  10. ncbi The human S100 protein MRP-14 is a novel activator of the beta 2 integrin Mac-1 on neutrophils
    R A Newton
    Leukocyte Adhesion Laboratory, Imperial Cancer Research Fund, London, United Kingdom
    J Immunol 160:1427-35. 1998

Detail Information

Publications178 found, 100 shown here

  1. ncbi Relative contribution of LFA-1 and Mac-1 to neutrophil adhesion and migration
    Z M Ding
    Speros P Martel Laboratory of Leukocyte Biology, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA
    J Immunol 163:5029-38. 1999
    ..Neutrophil extravasation in response to TNF-alpha in LFA-1-deficient mice dramatically decreased, whereas neutrophil extravasation in Mac-1-deficient mice markedly increased...
  2. ncbi Crystal structure of the A domain from the alpha subunit of integrin CR3 (CD11b/CD18)
    J O Lee
    Laboratory of X ray Crystallography, Dana Farber Cancer Institute, Harvard Medical School Boston, Massachusetts 02115
    Cell 80:631-8. 1995
    ..Our crystal structure will allow reliable models to be built for other members of the A domain superfamily and should facilitate development of novel adhesion modulatory drugs...
  3. pmc Characterization of the receptor-ligand pathways important for entry and survival of Francisella tularensis in human macrophages
    Ashwin Balagopal
    Department of Internal Medicine, Ohio State University, 420 W 12th Avenue, 216 Tzagournis Medical Research Facility, Columbus, OH 43210, USA
    Infect Immun 74:5114-25. 2006
    ..This study demonstrates that human macrophages phagocytose more Francisella than monocytes with contributions from CR3, Fcgamma receptors, the MR, and SP-A present in lung alveoli...
  4. pmc Leukocyte engagement of fibrin(ogen) via the integrin receptor alphaMbeta2/Mac-1 is critical for host inflammatory response in vivo
    Matthew J Flick
    Children s Hospital Research Foundation and the University of Cincinnati College of Medicine, Cincinnati, Ohio 45229 3039, USA
    J Clin Invest 113:1596-606. 2004
    ....
  5. pmc Dectin-1 is a major beta-glucan receptor on macrophages
    Gordon D Brown
    Sir William Dunn School of Pathology, University of Oxford, United Kingdom
    J Exp Med 196:407-12. 2002
    ..Furthermore, these results identify Dectin-1 as a new target for examining the immunomodulatory properties of beta-glucans for therapeutic drug design...
  6. pmc A subpopulation of Mac-1 (CD11b/CD18) molecules mediates neutrophil adhesion to ICAM-1 and fibrinogen
    M S Diamond
    Committee on Cell and Developmental Biology, Harvard Medical School, Boston, Massachusetts
    J Cell Biol 120:545-56. 1993
    ..Because CBRM1/5 recognizes a fraction of Mac-1 on activated neutrophils, but still blocks Mac-1-dependent adhesion to fibrinogen and ICAM-1, we suggest that only a small subset of Mac-1 molecules is competent to mediate adhesion...
  7. ncbi Microglia and macrophage activation and the regulation of complement-receptor-3 (CR3/MAC-1)-mediated myelin phagocytosis in injury and disease
    Shlomo Rotshenker
    Department of Anatomy and Cell Biology, Hebrew University Hadassah Medical School and the Eric Roland Center for Neurodegenerative Diseases, POB 12272, Jerusalem 91120, Israel
    J Mol Neurosci 21:65-72. 2003
    ..Monoclonal antibody-induced phagocytosis regulation must reveal a mechanism by which native extracellular molecules bind to and regulate CR3/MAC-1-mediated myelin phagocytosis in microglia and macrophages...
  8. ncbi Complement c3a and c5a induce different signal transduction cascades in endothelial cells
    Ingrid U Schraufstatter
    Department of Cancer Biology, La Jolla Institute for Molecular Medicine, San Diego, CA 92121, USA
    J Immunol 169:2102-10. 2002
    ..The C5aR in endothelial cells thus uses a signaling cascade-transactivation of the EGFR-that does not exist in leukocytes, while the C3aR couples to a different G protein, presumably G(alpha12/13)...
  9. ncbi Mice deficient in Mac-1 (CD11b/CD18) are less susceptible to cerebral ischemia/reperfusion injury
    S G Soriano
    Department of Anesthesia, Children s Hospital, Boston, MA 02115, USA
    Stroke 30:134-9. 1999
    ..To determine the role of Mac-1 during ischemia and reperfusion in the brain, we analyzed the effect of transient focal cerebral ischemia in mice genetically engineered with a specific deficiency in Mac-1...
  10. ncbi The human S100 protein MRP-14 is a novel activator of the beta 2 integrin Mac-1 on neutrophils
    R A Newton
    Leukocyte Adhesion Laboratory, Imperial Cancer Research Fund, London, United Kingdom
    J Immunol 160:1427-35. 1998
    ..We postulate that MRP-14 and MRP-8 are important in vivo candidates for the regulated adhesion of neutrophils through control of Mac-1 activity...
  11. ncbi Sequence gamma 377-395(P2), but not gamma 190-202(P1), is the binding site for the alpha MI-domain of integrin alpha M beta 2 in the gamma C-domain of fibrinogen
    Tatiana P Ugarova
    Joseph J Jacobs Center for Thrombosis and Vascular Biology, Department of Molecular Cardiology, Lerner Research Institute, Cleveland, Ohio 44195, USA
    Biochemistry 42:9365-73. 2003
    ..Thus, these data demonstrate the essential role of the P2, but not P1, sequence for binding of gamma C by the alpha(M)I-domain and suggest that the adhesive function of P2 depends on the minimal recognition motif NRLTIG...
  12. ncbi Identification of a novel recognition sequence for integrin alphaM beta2 within the gamma-chain of fibrinogen
    T P Ugarova
    Joseph J Jacobs Center for Thrombosis and Vascular Biology, Department of Molecular Cardiology, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Biol Chem 273:22519-27. 1998
    ..The juxtapositioning of these two sequences may form an unique and complex binding site for alphaM beta2...
  13. ncbi Bacterial phagocytosis activates extracellular signal-regulated kinase and p38 mitogen-activated protein kinase cascades in human neutrophils
    K R McLeish
    Department of Medicine, University of Louisville Health Sciences Center, Veterans Affairs Medical Center, Kentucky, USA
    J Leukoc Biol 64:835-44. 1998
    ..In conclusion, bacterial phagocytosis stimulates ERK and p38 activation by distinct signal transduction pathways. Phagocytosis-stimulated p38 kinase activity is necessary for optimal H2O2 production...
  14. ncbi Impaired mast cell development and innate immunity in Mac-1 (CD11b/CD18, CR3)-deficient mice
    A R Rosenkranz
    Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Immunol 161:6463-7. 1998
    ....
  15. ncbi Utilization of CD11b knockout mice to characterize the role of complement receptor 3 (CR3, CD11b/CD18) in the growth of Mycobacterium tuberculosis in macrophages
    M D Melo
    Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada
    Cell Immunol 205:13-23. 2000
    ..However, whether a mycobacterium will gain access to the intracellular environment, and the type of Mφ that the bacterium enters, is significantly affected by the presence or absence of CR3...
  16. pmc Intraluminal crawling of neutrophils to emigration sites: a molecularly distinct process from adhesion in the recruitment cascade
    Mia Phillipson
    Immunology Research Group, Department of Physiology and Biophysics, University of Calgary, Calgary T2N 4N1, Alberta, Canada
    J Exp Med 203:2569-75. 2006
    ..e., LFA-1-dependent adhesion followed by Mac-1-dependent crawling, and both steps ultimately contribute to efficient emigration out of the vasculature...
  17. ncbi Leukocyte integrin Mac-1 recruits toll/interleukin-1 receptor superfamily signaling intermediates to modulate NF-kappaB activity
    C Shi
    Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Circ Res 89:859-65. 2001
    ..Taken together, these observations indicate that Mac-1 recruits a Toll/IL-1 receptor family-like cascade to modulate NF-kappaB activity. This represents a new pathway for integrin-dependent modulation of gene expression...
  18. ncbi Delineation of the key amino acids involved in neutrophil inhibitory factor binding to the I-domain supports a mosaic model for the capacity of integrin alphaMbeta 2 to recognize multiple ligands
    Valentin A Ustinov
    Joseph J Jacobs Center for Thrombosis and Vascular Biology, and Department of Molecular Cardiology NB50, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Biol Chem 277:18769-76. 2002
    ..Thus, the alpha(M)I-domain appears to present a mosaic of exposed amino acids within surface loops on its MIDAS face, and different ligands interact with different residues to attain high affinity binding...
  19. ncbi A novel role for the beta 2 integrin CD11b/CD18 in neutrophil apoptosis: a homeostatic mechanism in inflammation
    A Coxon
    Department of Pathology, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Immunity 5:653-66. 1996
    ..Thus, CD11b/CD18 plays a novel and unsuspected homeostatic role in inflammation by accelerating the programmed elimination of extravasated neutrophils...
  20. pmc A peptide derived from the intercellular adhesion molecule-2 regulates the avidity of the leukocyte integrins CD11b/CD18 and CD11c/CD18
    R Li
    Department of Biochemistry, University of Helsinki, Finland
    J Cell Biol 129:1143-53. 1995
    ..These findings indicate that in addition to induction of CD11a/CD18-mediated cell adhesion, the ICAM-2 peptide may also serve as a "trigger" for high avidity ligand binding of other beta 2 integrins...
  21. pmc A role for Mac-1 (CDIIb/CD18) in immune complex-stimulated neutrophil function in vivo: Mac-1 deficiency abrogates sustained Fcgamma receptor-dependent neutrophil adhesion and complement-dependent proteinuria in acute glomerulonephritis
    T Tang
    Department of Pathology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Exp Med 186:1853-63. 1997
    ..Since Mac-1 on PMNs is the principal ligand for ic3b, an absence of Mac-1 interaction with C3 probably contributed to the abrogation of proteinuria in Mac-1-null mice...
  22. pmc Soluble beta-glucan polysaccharide binding to the lectin site of neutrophil or natural killer cell complement receptor type 3 (CD11b/CD18) generates a primed state of the receptor capable of mediating cytotoxicity of iC3b-opsonized target cells
    V Vetvicka
    The Division of Experimental Immunology and Immunopathology, Departmentof Pathology, University of Louisville, Kentucky 40292, USA
    J Clin Invest 98:50-61. 1996
    ..These polysaccharides function through binding to phagocyte or NK cell CR3, priming the receptor for cytotoxicity of neoplastic tissues that are frequently targeted with iC3b and sparing normal tissues that lack iC3b...
  23. ncbi In vivo developmental stages in murine natural killer cell maturation
    Sungjin Kim
    Howard Hughes Medical Institute and Rheumatology Division, Department of Internal Medicine, Barnes Jewish Hospital and Washington University School of Medicine, St Louis, MO 63110, USA
    Nat Immunol 3:523-8. 2002
    ....
  24. ncbi Functional receptor for C3a anaphylatoxin is expressed by normal hematopoietic stem/progenitor cells, and C3a enhances their homing-related responses to SDF-1
    Ryan Reca
    Stem Cell Biology Program, University of Louisville, Louisville, KY 40202, USA
    Blood 101:3784-93. 2003
    ..C3a is the first positive regulator of this axis to be identified...
  25. pmc Reversal of proinflammatory responses by ligating the macrophage Fcgamma receptor type I
    F S Sutterwala
    Department of Microbiology and Immunology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
    J Exp Med 188:217-22. 1998
    ..This reciprocal alteration in the pattern of macrophage cytokine production illustrates a potentially important role for FcgammaR-mediated clearance in suppressing macrophage proinflammatory responses...
  26. pmc The junctional adhesion molecule 3 (JAM-3) on human platelets is a counterreceptor for the leukocyte integrin Mac-1
    Sentot Santoso
    Institute for Clinical Immunology and Transfusion Medicine, Justus Liebig University, D 35385 Giessen, Germany
    J Exp Med 196:679-91. 2002
    ..JAM-3 thereby provides a novel molecular target for antagonizing interactions between vascular cells that promote inflammatory vascular pathologies such as in atherothrombosis...
  27. pmc Differential infection of mononuclear phagocytes by Francisella tularensis: role of the macrophage mannose receptor
    Grant S Schulert
    Inflammation Program and Department of Microbiology, University of Iowa, 2501 Crosspark Rd, Coralville, 52241, USA
    J Leukoc Biol 80:563-71. 2006
    ..Conversely, MDM used MR and CD11b/CD18 to ingest opsonized organisms. Altogether, our data demonstrate differential infection of mononuclear phagocytes by Ft and define distinct roles for MR and CR3 in phagocytosis...
  28. ncbi Shape and shift changes related to the function of leukocyte integrins LFA-1 and Mac-1
    N Hogg
    Leukocyte Adhesion Laboratory, Imperial Cancer Research Fund, London, England, UK
    J Leukoc Biol 69:893-8. 2001
    ..Leukocytes use LFA-1 to migrate across the endothelium. Active beta1 integrins may be required subsequently to bind the matrix proteins encountered by leukocytes as they continue their voyage into the tissue interior...
  29. ncbi Regulation of phagocytosis by Rho GTPases
    F Niedergang
    Membrane and Cytoskeleton Dynamics Group, Institut Curie, CNRS UMR144, 75248 Paris, France
    Curr Top Microbiol Immunol 291:43-60. 2005
    ..As reviewed here, Rho family GTPases, their activators, and their downstream effectors control the local reorganization of the actin cytoskeleton beneath bound particles...
  30. ncbi Interactions between Mycobacterium tuberculosis and host cells: are mycobacterial sugars the key?
    M R Ehlers
    BioNebraska Inc, Lincoln, NE 68524, USA
    Trends Microbiol 6:328-35. 1998
    ..Binding to specific receptors, such as complement receptor type 3, could provide an advantage. These interactions appear to involve surface polysaccharides and glycolipids...
  31. ncbi Two conformations of the integrin A-domain (I-domain): a pathway for activation?
    J O Lee
    Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Structure 3:1333-40. 1995
    ....
  32. ncbi Mac-1 signaling via Src-family and Syk kinases results in elastase-dependent thrombohemorrhagic vasculopathy
    Junichi Hirahashi
    Department of Pathology, Center for Excellence in Vascular Biology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Immunity 25:271-83. 2006
    ..These data suggest that Mac-1 engagement of complement activates tyrosine kinases to promote elastase-dependent blood vessel injury in vivo...
  33. pmc Cooperative interactions of LFA-1 and Mac-1 with intercellular adhesion molecule-1 in facilitating adherence and transendothelial migration of human neutrophils in vitro
    C W Smith
    Speros P Martel Laboratory of Leukocyte Biology, Baylor College of Medicine, Houston, Texas 77054
    J Clin Invest 83:2008-17. 1989
    ..The results in this report indicate that unstimulated neutrophils exhibit LFA-1-dependent attachment to ICAM-1, and chemotactic stimulation enhances the attachment of human neutrophils to ICAM-1 by a Mac-1-dependent process...
  34. ncbi The beta-glucan-binding lectin site of mouse CR3 (CD11b/CD18) and its function in generating a primed state of the receptor that mediates cytotoxic activation in response to iC3b-opsonized target cells
    Y Xia
    Division of Experimental Immunology and Immunopathology, Department of Pathology, University of Louisville, KY 40292, USA
    J Immunol 162:2281-90. 1999
    ..The similarity of mouse and human CR3 in response to beta-glucans highlights the utility of mouse tumor models for development of therapeutic beta-glucans...
  35. ncbi CD8alpha+ dendritic cells originate from the CD8alpha- dendritic cell subset by a maturation process involving CD8alpha, DEC-205, and CD24 up-regulation
    Gloria Martinez del Hoyo
    Department of Cell Biology, Faculty of Biology, Complutense University, 28040 Madrid, Spain
    Blood 99:999-1004. 2002
    ....
  36. pmc Enteropathogenic Escherichia coli mediates antiphagocytosis through the inhibition of PI 3-kinase-dependent pathways
    J Celli
    Biotechnology Laboratory, University of British Columbia, Vancouver, BC, V6T 1Z3, Canada
    EMBO J 20:1245-58. 2001
    ..This constitutes a novel mechanism of phagocytosis avoidance by an extracellular pathogen...
  37. ncbi 7E3 monoclonal antibody directed against the platelet glycoprotein IIb/IIIa cross-reacts with the leukocyte integrin Mac-1 and blocks adhesion to fibrinogen and ICAM-1
    D I Simon
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Arterioscler Thromb Vasc Biol 17:528-35. 1997
    ....
  38. ncbi Mac-1 (CD11b/CD18) mediates adherence-dependent hydrogen peroxide production by human and canine neutrophils
    S B Shappell
    Speros P Martel Leukocyte Biology Laboratory, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030
    J Immunol 144:2702-11. 1990
    ..These results indicate that Mac-1 (CD11b/CD18) can mediate adhesion-dependent H2O2 production by human and canine neutrophils exposed to chemotactic factors...
  39. ncbi Staphylococcus aureus extracellular adherence protein serves as anti-inflammatory factor by inhibiting the recruitment of host leukocytes
    Triantafyllos Chavakis
    Institute for Biochemistry, Third Department of Internal Medicine, Justus Liebig Universitat, Giessen, Germany
    Nat Med 8:687-93. 2002
    ....
  40. ncbi Macrophage phagocytosis of myelin in vitro determined by flow cytometry: phagocytosis is mediated by CR3 and induces production of tumor necrosis factor-alpha and nitric oxide
    L J van der Laan
    Department of Immunology and Cell Biology, Faculty of Medicine, Vrije Universiteit, Amsterdam, The Netherlands
    J Neuroimmunol 70:145-52. 1996
    ..Our results indicate an important role for CR3 in myelin phagocytosis. The induction of TNF-alpha and NO which accompanies this phagocytosis may further contribute to the overall process of demyelination during MS or EAE...
  41. ncbi Effects of IL-8, Gro-alpha, and LTB(4) on the adhesive kinetics of LFA-1 and Mac-1 on human neutrophils
    S M Seo
    Institute of Biosciences and Bioengineering, Rice University, Houston 77005, USA
    Am J Physiol Cell Physiol 281:C1568-78. 2001
    ..These kinetic and topographical differences may indicate distinct functional contributions of LFA-1 and Mac-1 on neutrophils...
  42. ncbi Transendothelial migration and trafficking of leukocytes in LFA-1-deficient mice
    D P Andrew
    Amgen Inc, Boulder, USA
    Eur J Immunol 28:1959-69. 1998
    ..Finally, whereas anti-CD31 mAb blocked WT monocyte and neutrophil transendothelial cell migration they did not block LFA-1-deficient monocyte and neutrophil transendothelial migration...
  43. ncbi Modulation (inhibition and augmentation) of complement receptor-3-mediated myelin phagocytosis
    F Reichert
    Department of Anatomy and Cell Biology, Hebrew University-Hadassah Medical School, Jerusalem, 91120, Israel
    Neurobiol Dis 8:504-12. 2001
    ....
  44. ncbi Regulated unmasking of the cryptic binding site for integrin alpha M beta 2 in the gamma C-domain of fibrinogen
    Valeryi K Lishko
    Joseph J Jacobs Center for Thrombosis and Vascular Biology, Department of Molecular Cardiology, Lerner Research Institute, Cleveland, Ohio 44195, USA
    Biochemistry 41:12942-51. 2002
    ....
  45. ncbi Mycobacterium tuberculosis-infected human macrophages exhibit enhanced cellular adhesion with increased expression of LFA-1 and ICAM-1 and reduced expression and/or function of complement receptors, FcgammaRII and the mannose receptor
    Lucy E DesJardin
    Veterans Admin Med Center and Depts of Medicine, Microbiology and the Interdisciplinary Immunology Program, University of Iowa, Iowa City, USA
    Microbiology 148:3161-71. 2002
    ....
  46. ncbi Glycosylation restores survival of chilled blood platelets
    Karin M Hoffmeister
    Division of Hematology, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Science 301:1531-4. 2003
    ..Platelet-associated galactosyltransferase produces efficient galactosylation when uridine diphosphate-galactose is added, affording a potentially simple method for storing platelets in the cold...
  47. pmc The adenylate cyclase toxin of Bordetella pertussis binds to target cells via the alpha(M)beta(2) integrin (CD11b/CD18)
    P Guermonprez
    Unit of Biology of Immune Regulations, Institut Pasteur, Paris, France
    J Exp Med 193:1035-44. 2001
    ..Thus, the cellular distribution of CD11b, mostly on neutrophils, macrophages, and dendritic and natural killer cells, supports a role for CyaA in disrupting the early, innate antibacterial immune response...
  48. ncbi Galectin-3/MAC-2, Ras and PI3K activate complement receptor-3 and scavenger receptor-AI/II mediated myelin phagocytosis in microglia
    Shlomo Rotshenker
    Department of Anatomy and Cell Biology, Hebrew University Faculty of Medicine, and The Eric Roland Center for Neurodegenerative Diseases, Jerusalem, Israel
    Glia 56:1607-13. 2008
    ..An explanation may thus be offered for deficient phagocytosis by microglia that express CR3/MAC-1 and SRAI/II without Galectin-3/MAC-2 and efficient phagocytosis when CR3/MAC-1 and SRAI/II are co-expressed with Galectin-3/MAC-2...
  49. pmc Platelet glycoprotein ibalpha is a counterreceptor for the leukocyte integrin Mac-1 (CD11b/CD18)
    D I Simon
    Cardiovascular Division, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Exp Med 192:193-204. 2000
    ..These observations provide a molecular target for disrupting leukocyte-platelet complexes that promote vascular inflammation in thrombosis, atherosclerosis, and angioplasty-related restenosis...
  50. pmc LFA-1 is sufficient in mediating neutrophil emigration in Mac-1-deficient mice
    H Lu
    Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030, USA
    J Clin Invest 99:1340-50. 1997
    ..Our results demonstrate that Mac-1 plays a critical role in mediating binding of neutrophils to fibrinogen and neutrophil degranulation, but is not necessary for effective neutrophil emigration, which is more dependent upon LFA-1...
  51. ncbi Uptake of serum-opsonized Francisella tularensis by macrophages can be mediated by class A scavenger receptors
    Lynda M Pierini
    Department of Surgery, Weill Medical College of Cornell University, New York, NY 10021, USA
    Cell Microbiol 8:1361-70. 2006
    ..tularensis infection, namely, blocking SRA as a means of hindering F. tularensis access to its intracellular niche...
  52. ncbi Adenylate cyclase toxin subverts phagocyte function by RhoA inhibition and unproductive ruffling
    Jana Kamanova
    Cellular and Molecular Microbiology Division, Institute of Microbiology of the Academy of Sciences of the Czech Republic, Prague 4, Czech Republic
    J Immunol 181:5587-97. 2008
    ....
  53. ncbi Rho-kinase and myosin-II control phagocytic cup formation during CR, but not FcgammaR, phagocytosis
    Isabel M Olazabal
    School of Biosciences, University of Birmingham, Edgbaston, B15 2TT, Birmingham, United Kingdom
    Curr Biol 12:1413-18. 2002
    ..While myosins have been previously implicated in FcgammaR phagocytosis, to our knowledge, this is the first demonstration of a role for myosin-II in CR phagocytosis...
  54. ncbi In vivo blood monocyte migration to acute inflammatory reactions, IL-1 alpha, TNF-alpha, IFN-gamma, and C5a utilizes LFA-1, Mac-1, and VLA-4. The relative importance of each integrin
    T B Issekutz
    Department of Medicine, University of Toronto, Ontario, Canada
    J Immunol 154:6533-40. 1995
    ..4) The initiating inflammatory stimulus also modifies monocyte integrin usage, supporting the multistep combinatorial model of leukocyte extravasation...
  55. pmc Decreased neointimal formation in Mac-1(-/-) mice reveals a role for inflammation in vascular repair after angioplasty
    D I Simon
    Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Clin Invest 105:293-300. 2000
    ..These data establish a role for inflammation in neointimal thickening and suggest that leukocyte recruitment to mechanically injured arteries may prevent restenosis...
  56. ncbi Tumor cell-derived prostaglandin E2 inhibits monocyte function by interfering with CCR5 and Mac-1
    R Zeidler
    Department of Otolaryngology, University of Munich, 81377 Munich, Germany
    FASEB J 14:661-8. 2000
    ..Since both dysfunctions can be restored with NSAIDs, our findings help to explain the molecular chemopreventive action of NSAIDs on tumor formation and progression...
  57. ncbi A role for mammalian diaphanous-related formins in complement receptor (CR3)-mediated phagocytosis in macrophages
    Emma Colucci-Guyon
    Membrane and Cytoskeleton Dynamics Group, Unite Mixte de Recherche 144, Centre National de la Recherche Scientifique Institut Curie, 75248 Paris, France
    Curr Biol 15:2007-12. 2005
    ..These results indicate a new function for mDia proteins in the regulation of actin polymerization during CR3-mediated phagocytosis...
  58. pmc An essential role for talin during alpha(M)beta(2)-mediated phagocytosis
    Jenson Lim
    Centre for Molecular Microbiology and Infection, Division of Cell and Molecular Biology, Imperial College London, London SW7 2AZ, United Kingdom
    Mol Biol Cell 18:976-85. 2007
    ..Our results establish for the first time at least two distinct roles for talin during CR3/alpha(M)beta(2)-mediated phagocytosis, most noticeably activation of the CR3/alpha(M)beta(2) receptor and phagocytic uptake...
  59. ncbi Regulation of CD11b/CD18 (Mac-1) adhesion to fibrinogen by urokinase receptor (uPAR)
    H Zhang
    The Sol Sherry Thrombosis Research Center, Temple University School of Medicine, 3400 North Broad Street, Philadelphia, PA 19140, USA
    Inflamm Res 52:86-93. 2003
    ..The goal of this study is to investigate the consequence of the interaction between Mac-1 and uPAR and determine the mechanisms by which uPAR regulates Mac-1 dependent adhesion to fibrinogen...
  60. ncbi Nitric oxide has a role in regulating VLA-4-integrin expression on the human neutrophil cell surface
    Nicola Conran
    Department of Pharmacology, FCM, UNICAMP, Campinas, Brazil
    Biochem Pharmacol 66:43-50. 2003
    ....
  61. ncbi Complement receptor 3 (CD11b/CD18) mediates type I and type II phagocytosis during nonopsonic and opsonic phagocytosis, respectively
    Véronique Le Cabec
    Institut de Pharmacologie et de Biologie Structurale, Centre National de la Recherche Scientifique, Toulouse, France
    J Immunol 169:2003-9. 2002
    ..Therefore, CR3 mediates type I phagocytosis under nonopsonic conditions and type II under opsonic conditions. This is the first evidence that a single receptor can mediate both types of phagocytosis depending on the ligand used...
  62. ncbi Molecular definition of the bovine granulocytopathy syndrome: identification of deficiency of the Mac-1 (CD11b/CD18) glycoprotein
    M E Kehrli
    National Animal Disease Center, USDA Agricultural Research Service, Ames, Iowa 50010
    Am J Vet Res 51:1826-36. 1990
    ..Bone marrow examination revealed diffuse myeloid hyperplasia, but no other abnormalities...
  63. ncbi A novel divalent cation-binding site in the A domain of the beta 2 integrin CR3 (CD11b/CD18) is essential for ligand binding
    M Michishita
    Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Charlestown 02129
    Cell 72:857-67. 1993
    ....
  64. ncbi Fibrinogen activates NF-kappa B transcription factors in mononuclear phagocytes
    R G Sitrin
    Department of Internal Medicine, University of Michigan, Ann Arbor 48109, USA
    J Immunol 161:1462-70. 1998
    ..We conclude that contact with fibrinogen-derived proteins may contribute to mononuclear phagocyte activation by signaling through CD11b/CD18, resulting in selective activation of transcriptional regulatory factors, including NF-kappa B...
  65. pmc Specific activation of leukocyte beta2 integrins lymphocyte function-associated antigen-1 and Mac-1 by chemokines mediated by distinct pathways via the alpha subunit cytoplasmic domains
    K S Weber
    Institut für Prophylaxe der Kreislaufkrankheiten, Ludwig Maximilians Universitat, D 80336 MUnchen, Germany
    Mol Biol Cell 10:861-73. 1999
    ..Our data suggest that a specific regulation of beta2 integrin avidity by chemokines may be important in leukocyte extravasation and may be triggered by distinct activation pathways transduced via the alpha subunit cytoplasmic domains...
  66. pmc Transfer of type II collagen-induced arthritis from DBA/1 to severe combined immunodeficiency mice can be prevented by blockade of Mac-1
    P C Taylor
    Kennedy Institute of Rheumatology, London, UK
    Immunology 88:315-21. 1996
    ..Our findings support the hypothesis that cells expressing Mac-1 play an important role in the induction and maintenance of joint damage in collagen-induced arthritis...
  67. ncbi Fibrin(ogen)-alpha M beta 2 interactions regulate leukocyte function and innate immunity in vivo
    Matthew J Flick
    Children s Hospital Research Foundation and the University of Cincinnati College of Medicine, Cincinnati, OH 45229 3039, USA
    Exp Biol Med (Maywood) 229:1105-10. 2004
    ..Finally, the Fib gamma(390-396A) mice represent a valuable system for better defining the contribution of fibrin(ogen) to the inflammatory response in the absence of any confounding alteration in clotting function...
  68. ncbi Identification and reconstruction of the binding site within alphaMbeta2 for a specific and high affinity ligand, NIF
    L Zhang
    Joseph J Jacobs Center for Thrombosis and Vascular Biology, Department of Molecular Cardiology, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Biol Chem 272:17558-64. 1997
    ..Verifying this localization, when these segments were introduced into the alphaXI-domain, the resulting chimeric receptor was converted into a high affinity NIF-binding protein...
  69. ncbi Regulation of leukocyte recruitment by polypeptides derived from high molecular weight kininogen
    T Chavakis
    Institute for Biochemistry, and, Third Department of Internal Medicine, Justus Liebig Universitat, Giessen, Germany
    FASEB J 15:2365-76. 2001
    ....
  70. ncbi Identification of the binding site for fibrinogen recognition peptide gamma 383-395 within the alpha(M)I-domain of integrin alpha(M)beta2
    V P Yakubenko
    Joseph J. Jacobs Center for Thrombosis and Vascular Biology and the Department of Molecular Cardiology, Lerner Research Institute, Cleveland, Ohio 44195, USA
    J Biol Chem 276:13995-4003. 2001
    ....
  71. ncbi Complement-receptor-3 and scavenger-receptor-AI/II mediated myelin phagocytosis in microglia and macrophages
    Fanny Reichert
    Department of Anatomy and Cell Biology, Hebrew University Hadassah Medical School and the Eric Roland Center for Neurodegenerative Diseases, Jerusalem 91120, Israel
    Neurobiol Dis 12:65-72. 2003
    ..We further document SRAI/II mediated myelin phagocytosis in microglia and CR3/MAC-1 contributing to myelin phagocytosis two- to threefold more than SRAI/II when the two receptors function together...
  72. pmc Integrin engagement regulates monocyte differentiation through the forkhead transcription factor Foxp1
    Can Shi
    Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Clin Invest 114:408-18. 2004
    ..This represents a new pathway for integrin-dependent modulation of gene expression and control of cellular differentiation...
  73. ncbi ICAM-1-dependent pathways regulate colonic eosinophilic inflammation
    Elizabeth Forbes
    Allergy and Inflammation Research Group, Division of Biochemistry and Molecular Biology, The John Curtin School of Medical Research, Australian National University, Canberra, Australia
    J Leukoc Biol 80:330-41. 2006
    ..These studies demonstrate that beta2 -integrin/ICAM-1-dependent pathways are integral to eosinophil recruitment into the colon during GI inflammation associated with colonic injury...
  74. pmc A novel form of integrin dysfunction involving beta1, beta2, and beta3 integrins
    Alison McDowall
    Leukocyte Adhesion Laboratory, Cancer Research UK London Research Institute, Lincoln s Inn Fields Laboratories, London, United Kingdom
    J Clin Invest 111:51-60. 2003
    ....
  75. pmc Changes in activation states of murine polymorphonuclear leukocytes (PMN) during inflammation: a comparison of bone marrow and peritoneal exudate PMN
    Takuya Itou
    Department of Preventive Veterinary Medicine and Animal Health, Nihon University School of Veterinary Medicine, Nihon University, 1866 Kameino, Fujisawa, Kanagawa 252 8510, Japan
    Clin Vaccine Immunol 13:575-83. 2006
    ..These results have major implications for murine neutrophil research and show the importance of defining which PMN subsets to use when investigating murine models...
  76. ncbi CR3 (CD11b/CD18) is the major macrophage receptor for IgM antibody-mediated phagocytosis of African trypanosomes: diverse effect on subsequent synthesis of tumor necrosis factor alpha and nitric oxide
    Wanling Pan
    Department of Veterinary Microbiology, Western College of Veterinary Medicine, University of Saskatchewan, 52 Campus Drive, Saskatoon, SK S7N 5B4, Canada
    Microbes Infect 8:1209-18. 2006
    ..congolense enhances synthesis of disease-producing TNF-alpha and inhibits synthesis of parasite-controlling NO. We suggest that signaling of inhibition of NO synthesis is mediated via CR3...
  77. ncbi Hypercapnic acidosis attenuates endotoxin-induced nuclear factor-[kappa]B activation
    Kei Takeshita
    Department of Medicine, School of Medicine, Keio University, Tokyo, Japan
    Am J Respir Cell Mol Biol 29:124-32. 2003
    ....
  78. ncbi Recruitment of Chlamydia pneumoniae-infected macrophages to the carotid artery wall in noninfected, nonatherosclerotic mice
    Andreas E May
    Deutsches Herzzentrum und 1 Medizinische Klinik, Klinikum rechts der Isar, Germany
    Arterioscler Thromb Vasc Biol 23:789-94. 2003
    ..However, the role of C pneumoniae for monocyte recruitment is unknown. The aim of this study was to examine the impact of C pneumoniae on monocyte adhesion and migration...
  79. ncbi Proinflammatory activities of S100: proteins S100A8, S100A9, and S100A8/A9 induce neutrophil chemotaxis and adhesion
    Carle Ryckman
    Infectious Diseases Research Center, Laval University Hospital Center, Sainte Foy, Quebec, Canada
    J Immunol 170:3233-42. 2003
    ..These studies 1) show that S100A8, S100A9, and S100A8/A9 are potent stimulators of neutrophils and 2) strongly suggest that these proteins are involved in neutrophil migration to inflammatory sites...
  80. ncbi Downregulation of mac-1 expression in monocytes by surface-bound IgG
    P X Fernández-Calotti
    Laboratorio de Immunologia, IIHEMA, Academia Nacional de Medicina, Buenos Aires, Argentina
    Scand J Immunol 57:35-44. 2003
    ..However, there was no inhibition of TNF-alpha production induced by zymosan, suggesting that Mac-1-dependent responses require different levels of its expression to be fully activated...
  81. ncbi Distinct roles of Mac-1 and its counter-receptors in neonatal obstructive nephropathy
    B Lange-Sperandio
    Department of Pediatrics, University of Heidelberg, Heidelberg, Germany
    Kidney Int 69:81-8. 2006
    ..ICAM-1 and its new ligands RAGE and JAM-C are sequentially activated in UUO. Blocking of Mac-1 and its ligands may confer synergistic renoprotective effects in neonatal obstructive nephropathy...
  82. pmc CD44-mediated phagocytosis induces inside-out activation of complement receptor-3 in murine macrophages
    Eric Vachon
    Division of Respirology, Department of Medicine, University of Toronto, Toronto, ON, Canada
    Blood 110:4492-502. 2007
    ..In addition, buffering of intracellular Ca(2+) did not affect CD44-mediated phagocytosis. Taken together, these data suggest that CD44 stimulation induces inside-out activation of CR3 through the GTPase Rap1...
  83. ncbi Mac-1, but not LFA-1, uses intercellular adhesion molecule-1 to mediate slow leukocyte rolling in TNF-alpha-induced inflammation
    Jessica L Dunne
    Department of Biomedical Engineering and Cardiovascular Research Center, University of Virginia Health Sciences Center, Charlottesville, VA 22908, USA
    J Immunol 171:6105-11. 2003
    ..However, blocking both Mac-1 and ICAM-1 had no greater effect than either blockade alone. We conclude that endothelial ICAM-1 is the main ligand responsible for slow leukocyte rolling mediated by Mac-1, but not LFA-1...
  84. pmc Kinetics analysis of binding between melanoma cells and neutrophils
    Meghan H Hoskins
    Department of Bioengineering, The Pennsylvania State University, University Park, Pennsylvania 16802 6804, USA
    Mol Cell Biomech 3:79-87. 2006
    ....
  85. ncbi Impaired integrin-dependent function in Wiskott-Aldrich syndrome protein-deficient murine and human neutrophils
    Hong Zhang
    Department of Laboratory Medicine, University of California, San Francisco, California 94143, USA
    Immunity 25:285-95. 2006
    ..These results suggest that impaired beta2 integrin function in WASp-deficient PMNs may contribute substantially to the clinical immunodeficiency suffered by WAS patients...
  86. ncbi Arteriogenesis proceeds via ICAM-1/Mac-1- mediated mechanisms
    Imo E Hoefer
    Research Group for Experimental and Clinical Arteriogenesis at the Department of Cardiology, University of Freiburg, Freiburg, Germany
    Circ Res 94:1179-85. 2004
    ....
  87. ncbi Human alloantibody anti-Mart interferes with Mac-1-dependent leukocyte adhesion
    Ulrich J H Sachs
    Institute for Clinical Immunology and Transfusion Medicine, Justus Liebig University, Giessen, Germany
    Blood 104:727-34. 2004
    ..In conclusion, some anti-Mart alloantibodies interfere with Mac-1-dependent cellular functions of neutrophils, cause NAIN, and may be used as tools for studying Mac-1-dependent functions...
  88. ncbi Bone marrow from CD18-/- (MAC-1-/-) homozygous deletion recombinant negative mice demonstrates increased longevity in long-term bone marrow culture and decreased contribution to irradiation pulmonary damage
    Michael W Epperly
    Department of Radiation Oncology, University of Pittsburgh Cancer Institute, University of Pittsburgh Medical Center, PA 15213, USA
    In Vivo 20:431-8. 2006
    ..We sought to determine if this interaction affected the growth of marrow in long-term bone marrow cultures (LTBMCs) and macrophage migration to the irradiated lung in pulmonary fibrosis/organizing alveolitis...
  89. pmc A novel pathway of HMGB1-mediated inflammatory cell recruitment that requires Mac-1-integrin
    Valeria V Orlova
    Experimental Immunology Branch, NCI, NIH, Bethesda, MD 20892, USA
    EMBO J 26:1129-39. 2007
    ..Together, a novel HMGB1-dependent pathway for inflammatory cell recruitment and activation that requires the functional interplay between Mac-1 and RAGE is described here...
  90. pmc Neutrophils influence melanoma adhesion and migration under flow conditions
    Margaret J Slattery
    Department of Bioengineering and The Huck Institute for Life Sciences, The Pennsylvania State University, University Park, PA 16802, USA
    Int J Cancer 106:713-22. 2003
    ..These results suggest that transmigration of C8161 cells under flow conditions can be influenced by PMNs, mediated by Mac-1/ICAM-1 adhesive interactions and enhanced by altered cytokine production...
  91. ncbi Manifestations of inflammatory arthritis are critically dependent on LFA-1
    Gerald M Watts
    Division of Rheumatology, Immunology, and Allergy, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 174:3668-75. 2005
    ..Blocking mAbs further revealed an ongoing requirement for LFA-1 I-domain adhesive function in disease perpetuation. These findings suggest that the LFA-1 I-domain forms an attractive target for treatment of human inflammatory arthritis...
  92. pmc Influence of CR3 (CD11b/CD18) expression on phagocytosis of Bordetella pertussis by human neutrophils
    Paula S Mobberley-Schuman
    Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati, 231 Albert Sabin Way, Cincinnati, OH 45267 0524, USA
    Infect Immun 73:7317-23. 2005
    ..These studies suggest that the activation and surface expression of CR3, FHA expression, and the efficiency of ACT internalization all influence whether B. pertussis will be phagocytosed and ultimately killed by neutrophils...
  93. pmc Src family kinases mediate neutrophil adhesion to adherent platelets
    Virgilio Evangelista
    Laboratory of Vascular Biology and Pharmacology, Consorzio Mario Negri Sud, Via Nazionale 8 A, 66030 Santa Maria Imbaro, Italy
    Blood 109:2461-9. 2007
    ..These results definitely establish a role for SFKs in PMN recruitment by activated platelets and suggest novel targets to disrupt the pathophysiologic consequences of platelet-leukocyte interactions in vascular disease...
  94. ncbi Mac-1 (CD11b/CD18) as accessory molecule for Fc alpha R (CD89) binding of IgA
    Annemiek B van Spriel
    Immunotherapy Laboratory, Department of Immunology, University Medical Center, Medarex Europe, and Genmab, Utrecht, The Netherlands
    J Immunol 169:3831-6. 2002
    ..Binding studies showed the secretory component, by itself, to interact with Mac-1-expressing PMN, but not with Mac-1(-/-) PMN. These data demonstrate an essential role for Mac-1 in establishing SIgA-FcalphaRI interactions...
  95. ncbi Modulation of Mac-1 (CD11b/CD18)-mediated adhesion by the leukocyte-specific protein 1 is key to its role in neutrophil polarization and chemotaxis
    Chunjie Wang
    Cellular and Molecular Biology Division, Toronto Western Research Institute, Canada
    J Immunol 169:415-23. 2002
    ....
  96. ncbi Urokinase receptor-deficient mice have impaired neutrophil recruitment in response to pulmonary Pseudomonas aeruginosa infection
    M R Gyetko
    Pulmonary and Critical Care Medicine Division, Department of Internal Medicine, Ann Arbor Veterans Affairs Medical Center and University of Michigan Medical Center, Ann Arbor, MI 48109, USA
    J Immunol 165:1513-9. 2000
    ..aeruginosa. This is the first report of a requirement for uPAR during cellular recruitment in vivo against a clinically relevant pathogen...
  97. ncbi Peroxynitrite induces integrin-dependent adhesion of human neutrophils to endothelial cells via activation of the Raf-1/MEK/Erk pathway
    C Zouki
    Research Center, Maisonneuve-Rosemont Hospital and Department of Medicine, , , , Canada H1T 2M4
    FASEB J 15:25-27. 2001
    ....
  98. ncbi Dietary restriction impairs neutrophil exudation by reducing CD11b/CD18 expression and chemokine production
    S Ikeda
    Department of Surgery, Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan
    Arch Surg 136:297-304. 2001
    ..Even brief nutritional replenishment in diet-restricted patients may improve host defense via restoring these PMN functions and chemokine production at local inflammatory sites...
  99. ncbi [Study of the function of leukocyte adhesion molecules in chronic respiratory diseases]
    Yujie Chen
    Department of Respiratory Medicine, The Fourth Hospital of Sichuan Province, Chengdu 610016, China
    Zhonghua Jie He He Hu Xi Za Zhi 25:94-7. 2002
    ..To study the function of leukocyte adhesion molecules in the pathogenesis of Chronic Obstructive Pulmonary Diseases (COPD) and cor pulmonale, and to evaluate the effect of anti-leukocyte-adhesion therapy for cor pulmonale...
  100. ncbi Kinetics of CD11b/CD18 up-regulation during infection with the agent of human granulocytic ehrlichiosis in mice
    Dori L Borjesson
    Center for Comparative Medicine, School of Medicine, University of California, Davis, California 95616, USA
    Lab Invest 82:303-11. 2002
    ..The data support crucial roles of CD11b/CD18 and IFN-gamma-mediated cell activation as mechanisms that limit bacterial replication...
  101. ncbi Opioid receptors on bone marrow neutrophils modulate chemotaxis and CD11b/CD18 expression
    A Kulkarni-Narla
    Department of Veterinary Pathobiology, University of Minnesota, 1988 Fitch Avenue, St. Paul, MN 55108-6010, USA
    Eur J Pharmacol 414:289-94. 2001
    ..The results indicate that kappa-opioid receptors expressed by neutrophils rapidly modulate chemotaxis and adhesion in vitro...

Research Grants51

  1. Mac-1 (CR3) and Fc gamma receptors in immune-mediated neutrophil cytotoxicity
    Tanya N Mayadas; Fiscal Year: 2013
    ..This could lead to the identification of targeted therapeutic strategies that attenuate organ injury while minimally immunocompromising the host. ..
  2. Role of Eosinophils in Airway Inflammation and Remodeling
    Nizar N Jarjour; Fiscal Year: 2013
    ..Given the prominence of eosinophilic inflammation in a significant proportion of severe asthma patients, these advances will have direct implications for the patients most affected by this very common illness. ..
  3. Leukadherins as novel compounds for treating restenosis
    ROBERTO IRENARDO VAZQUEZ PADRON; Fiscal Year: 2013
    ..This will pave the way for the future discovery of novel therapeutic agents to treat restenosis after PCI as well as other vascular inflammatory diseases. ..
  4. CONTROL OF BLOOD ACTIVATION DURING OPEN HEART SURGERY
    L Edmunds; Fiscal Year: 2002
    ..Because blood reactions during CPB and OHS are often mutually interdependent, we plan to study combinations of inhibitors that we believe will act synergistically. ..
  5. COMPLEMENT AND OPPORTUNISTIC MYCOBACTERIA IN AIDS
    MARCUS HORWITZ; Fiscal Year: 1990
    ..Tuberculosis is correlated with CR1 and/or CR3 receptor number; f) Select mutant M. tuberculosis that do not fix C3 and determine if they are phagocytized by monocytes; g) Purify the M. tuberculosis C3-acceptor molecule(s)...
  6. BIACORE 3000 SURFACE PLASMON RESONANCE INSTRUMENT
    Dudley Strickland; Fiscal Year: 2001
    ..The availability of this instrument will greatly enhance the ability of these NIH-funded investigators to achieve their aims and will accelerate the development of knowledge required to better understand a variety of pathologies...
  7. The Urokinase-CD87 System in Macrophage Activation
    Robert Sitrin; Fiscal Year: 2004
    ....
  8. Lipid Raft Microdomains in Neutrophil Function
    ROBERT GARY SITRIN; Fiscal Year: 2010
    ..Hopefully, targeting the function of lipid raft microdomains will engender new therapeutic strategies for enhancing antimicrobial defenses and suppressing the deleterious effects of acute inflammation. ..
  9. Molecular Mechanisms That Regulate CD11d Expression
    JOHN NOTI; Fiscal Year: 2004
    ..Transgenic analysis of the CD11d cis elements will be done to complement these studies. These studies will expand our understanding of normal myeloid development and leukemogenesis. ..
  10. Aging, CRH Stress Pathways and Atherogenic Processes
    Laura Redwine; Fiscal Year: 2002
    ..This knowledge may ultimately contribute to the development of novel drug therapies. ..
  11. Tai Chi: Well-Being and Heart Failure
    Laura Redwine; Fiscal Year: 2007
    ..Health education would be used as a control group rather than usual care to control for social interactions in the other two groups. [unreadable] [unreadable]..
  12. Mechanisms of Eosinophil Adhesion
    Xiangdong Zhu; Fiscal Year: 2006
    ..Knowledge of the signaling components required for eosinophil adhesion may provide insight into the pathogenesis of airway inflammation and lead to therapeutic interventions for human asthma. ..
  13. Erythropoietin receptors in breast cancer
    MURAT ARCASOY; Fiscal Year: 2008
    ..abstract_text> ..
  14. Mechanisms of Disease Progression in EAE
    Richard Jones; Fiscal Year: 2007
    ..Aim 3 will evaluate the number and phenotype of regulatory T cells capable of blocking or reducing disease. [unreadable] [unreadable]..
  15. The Role of C3 and C3 receptors in Experimental Autoimmune Encephalomyelitis
    Scott Barnum; Fiscal Year: 2007
    ..These proposed studies will provide important new information with respect to the role of complement in demyelinating disease and point to potential therapeutic approaches for MS. ..
  16. Neutrophil-Mediated Melanoma Cell Adhesion and Migration
    Cheng Dong; Fiscal Year: 2006
    ..Furthermore, since adhesion is a critical step in tumor metastasis these studies may identify novel therapeutic targets against invasive melanomas. [unreadable] [unreadable]..
  17. CD8 T cell response to vaccinia following lymphopenia
    STEPHEN JAMESON; Fiscal Year: 2006
    ..Finally, in Aim #3, we will reverse the experimental system and ask whether bona fide memory T cells are able to participate in homeostatic proliferation and whether these ceils maintain their functional properties. ..
  18. CD8 T Lymphocyte Regulation of EAE Disease Phenotype
    Michael Carrithers; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  19. Homeostatic Proliferation and Memory CD8 T Cells
    STEPHEN JAMESON; Fiscal Year: 2007
    ..abstract_text> ..
  20. Cell-mediated protection against pneumonic plague
    STEPHEN SMILEY; Fiscal Year: 2008
    ..abstract_text> ..
  21. High Throughput Screen for Novel Inhibitors of Platelet Integrin alphaIIb-beta3
    Barry Coller; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  22. Neutrophil-macrophage Interactions Govern Liver Immunity
    Stephen H Gregory; Fiscal Year: 2010
    ..Consequently, they should provide valuable insights that enable the development of innovative strategies to improve treatment and prevent the devastating consequencesoften associated with septicemia and sepsis. ..
  23. Improved Vaccines for Rift Valley Fever Virus
    Mark T Heise; Fiscal Year: 2010
    ....
  24. Multiscale modeling of leukocyte-tumor cell adhesion to endothelium in shear flow
    Cheng Dong; Fiscal Year: 2010
    ....
  25. TOGAVIRUS TROPISM FOR BONES, JOINTS, AND CNS
    Mark T Heise; Fiscal Year: 2010
    ....
  26. Role of gamma' Fibrinogen in Cardiovascular Disease
    David Farrell; Fiscal Year: 2006
    ..2) To determine the relationship between fibrinogen isoforms and established cardiovascular disease risk factors. 3) To determine if the fibrinogen isoforms in plasma are independently associated with CVD. ..
  27. THE ROLE OF UROKINASE IN LUNG T LYMPHOCYTE RESPONSES
    MARGARET GYETKO; Fiscal Year: 2003
    ..Determine if recombinant uPA can reverse the functional abnormalities in uPA minus/minus lymphocytes. ..
  28. Novel On-line Education in Protection of Human Subjects
    Barry Coller; Fiscal Year: 2003
    ..Questionnaires for researchers and data queries of the educational system will be designed to conduct research describing the impact of the training program on trainees and investigators. ..
  29. STATS in Bryostatin 1 induced differentiation of CLL
    Traci Battle; Fiscal Year: 2003
    ..particularly when combined with other antileukemia drugs. ..
  30. Developmental regulation of CD8 class I MHC binding
    STEPHEN JAMESON; Fiscal Year: 2004
    ..We will determine whether CD8beta plays a unique role in non-cognate Class I binding and in affecting the specific contact sites on the Class I MHC molecule to which CD8 binds. ..
  31. Priming CD4+ T cells to protect against pneumonic plague
    STEPHEN SMILEY; Fiscal Year: 2004
    ..Our long-term goals are to use that information to develop effective pneuinonic plague vaccines. ..
  32. ROLE OF FIBRINOGEN IN FIBRINOLYSIS
    David Farrell; Fiscal Year: 2004
    ..The results from the experiments in this proposal should provide new knowledge about the process of fibrinolysis that may lead to ways of modulating fibrin clot stability and clot lysis in vivo. ..
  33. Non-Immunogenic Peptide Anticoagulant
    David Farrell; Fiscal Year: 2003
    ..At the conclusion of these studies, essential milestones will be achieved for Phase II development of the gamma' peptide as a pharmacologic anticoagulant. ..
  34. LEUKOCYTE INTEGRIN ALPHA M BETA 2
    Edward Plow; Fiscal Year: 2004
    ....
  35. THE STRUCTURE AND FUNCTION OF PLATELET GPIIB-IIIA
    Edward Plow; Fiscal Year: 2003
    ..At the same time, these studies may have direct bearing on the use and future development of the GPIIb-IIIa blockers as antithrombotic agents. ..
  36. FRANCISELLA TULARENSIS: INNATE RESISTANCE TO IHALATION
    Stephen Gregory; Fiscal Year: 2004
    ..abstract_text> ..
  37. Thrombospondins and Atherothrombosis
    Edward Plow; Fiscal Year: 2004
    ..Together, these studies should provide a rigorous test of the hypothesis and extend our knowledge of the roles of the TSPs in cardiovascular biology. ..
  38. Roles for coagulation in immunity
    STEPHEN SMILEY; Fiscal Year: 2005
    ..Deciphering those mechanisms may lead to improved vaccines and/or treatments for pathologies characterized by fibrin deposition, including autoimmunity, allograft rejection, cancer and septic shock. ..
  39. MECHANISMS OF INFLAMMATORY LIVER INJURY
    C Smith; Fiscal Year: 2001
    ..Specific Aim 4 will define the potential sources and function of soluble ICAM-1 in inflammatory liver injury. ..
  40. IN UTERO STEM CELL TRANSFER IN MPS VII
    Brian Soper; Fiscal Year: 2005
    ..abstract_text> ..
  41. Molecular Mechanisms in TCR Reactivity to Self Ligands
    STEPHEN JAMESON; Fiscal Year: 2005
    ..This has health implications for recovery of the T-cell pool in patients suffering from T lymphopenia due to disease (e.g. AIDS), or therapeutic treatments (such as bone morrow transplant). ..
  42. SIGNAL TRANSDUCTION AND MOTILITY IN TUMOR CELL MIGRATION
    Cheng Dong; Fiscal Year: 2002
    ....
  43. EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS--INHIBITION OF C
    Scott Barnum; Fiscal Year: 2002
    ..These studies will also provide the basis for future work examining the potential for complement-inhibiting biological reagents as therapeutic adjuvants in MS. ..
  44. Conference on Central Nervous System Inflammation
    Scott Barnum; Fiscal Year: 2005
    ..The meeting program is composed of a diverse group of investigators (over 45% are women, ethnic minorities or young investigators) and less than 40% of the program speakers receive NIH funding. ..
  45. 2004 Hemostasis Gordon Research Conference
    Edward Plow; Fiscal Year: 2004
    ..The Hemostasis Gordon Conference has been a highly successful and enjoyable meeting, frequently identified as the best meeting attended by participants; and we believe that the current program has the potential to extend this tradition. ..
  46. Screening for Inhibitors of F. tularensis Virulence
    LYNDA PIERINI; Fiscal Year: 2004
    ..Small molecule modulators of F tularensis-macrophage interactions will be used in future experiments to identify virulence factors, and may provide leads for post-attack prophylaxes. ..
  47. CHARACTERIZATION AND TREATMENT OF MURINE MPS VII
    Brian Soper; Fiscal Year: 2006
    ..Differentiation capacity will be compared to directly brain implanted SC. Behavioral studies will determine long-term neurological function. ..
  48. Liver innate immunity in drug-induced liver disease
    Zhang Xu Liu; Fiscal Year: 2006
    ..Kaplowitz and the center members at the outstanding environment of USC Research Center for Liver Diseases. ..
  49. Arbovirus Evasion of Type I Interferon Induction
    Mark Heise; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  50. Structural Basis of Novel Hookworm Vaccines
    Oluwatoyin Asojo; Fiscal Year: 2006
    ..56 Angstroms (protein data bank code 1U53). In addition, a 2 PR-1 domain ASP (Na-ASP-1) has been crystallized with data up to 2.7 Angstroms. [unreadable] [unreadable] [unreadable]..
  51. The Mechanism of IVIG Action in Pemphigus
    Zhi Liu; Fiscal Year: 2006
    ..The overall goal of this project is to study the mechanisms of WIG action in autoantibody-mediated diseases and develop novel therapies to replace current immunosuppressive treatments, which confer severe side effects. ..