immunologic receptors

Summary

Summary: Cell surface molecules on cells of the immune system that specifically bind surface molecules or messenger molecules and trigger changes in the behavior of cells. Although these receptors were first identified in the immune system, many have important functions elsewhere.

Top Publications

  1. ncbi Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function
    O Adachi
    Department of Biochemistry, Hyogo College of Medicine, Nishinomiya, Japan
    Immunity 9:143-50. 1998
  2. ncbi NK cell recognition
    Lewis L Lanier
    Department of Microbiology and Immunology and the Cancer Research Institute, University of California, San Francisco School of Medicine, San Francisco, California 94143 0414, USA
    Annu Rev Immunol 23:225-74. 2005
  3. ncbi RAGE mediates a novel proinflammatory axis: a central cell surface receptor for S100/calgranulin polypeptides
    M A Hofmann
    College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Cell 97:889-901. 1999
  4. ncbi The biology of human natural killer-cell subsets
    M A Cooper
    Dept of Veterinary Biosciences and Comprehensive Cancer Center, The Ohio State University, 458A Starling-Loving Hall, 320 West 10th Ave, Columbus, OH 43210, USA
    Trends Immunol 22:633-40. 2001
  5. ncbi Cloning and expression of a cell surface receptor for advanced glycosylation end products of proteins
    M Neeper
    Department of Cellular and Molecular Biology, Merck Sharp and Dohme Research Laboratories, West Point, Pennsylvania 19486
    J Biol Chem 267:14998-5004. 1992
  6. ncbi Involvement of toll-like receptors 2 and 4 in cellular activation by high mobility group box 1 protein
    Jong Sung Park
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Biol Chem 279:7370-7. 2004
  7. ncbi TREM-1 amplifies inflammation and is a crucial mediator of septic shock
    A Bouchon
    Basel Institute for Immunology, Grenzacherstrasse 487, CH 4005 Basel, Switzerland
    Nature 410:1103-7. 2001
  8. ncbi Mechanisms of phagocytosis in macrophages
    A Aderem
    Department of Immunology, University of Washington, Seattle 98195, USA
    Annu Rev Immunol 17:593-623. 1999
  9. ncbi HLA and NK cell inhibitory receptor genes in resolving hepatitis C virus infection
    Salim I Khakoo
    Liver Group, Division of Infection, Inflammation, and Repair, Southampton University, Southampton 5016 6YD, UK
    Science 305:872-4. 2004
  10. ncbi Epistatic interaction between KIR3DS1 and HLA-B delays the progression to AIDS
    Maureen P Martin
    Basic Research Program, SAIC Frederick, Frederick, Maryland 21702 1201, USA
    Nat Genet 31:429-34. 2002

Detail Information

Publications296 found, 100 shown here

  1. ncbi Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function
    O Adachi
    Department of Biochemistry, Hyogo College of Medicine, Nishinomiya, Japan
    Immunity 9:143-50. 1998
    ..Taken together, these results demonstrate that MyD88 is a critical component in the signaling cascade that is mediated by IL-1 receptor as well as IL-18 receptor...
  2. ncbi NK cell recognition
    Lewis L Lanier
    Department of Microbiology and Immunology and the Cancer Research Institute, University of California, San Francisco School of Medicine, San Francisco, California 94143 0414, USA
    Annu Rev Immunol 23:225-74. 2005
    ..Here, I review the structure, function, and ligand specificity of the receptors responsible for NK cell recognition...
  3. ncbi RAGE mediates a novel proinflammatory axis: a central cell surface receptor for S100/calgranulin polypeptides
    M A Hofmann
    College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Cell 97:889-901. 1999
    ..These data highlight a novel paradigm in inflammation and identify roles for EN-RAGEs and RAGE in chronic cellular activation and tissue injury...
  4. ncbi The biology of human natural killer-cell subsets
    M A Cooper
    Dept of Veterinary Biosciences and Comprehensive Cancer Center, The Ohio State University, 458A Starling-Loving Hall, 320 West 10th Ave, Columbus, OH 43210, USA
    Trends Immunol 22:633-40. 2001
    ..In addition, we will discuss other cell-surface receptors expressed differentially by human NK-cell subsets and the distinct functional properties of these subsets...
  5. ncbi Cloning and expression of a cell surface receptor for advanced glycosylation end products of proteins
    M Neeper
    Department of Cellular and Molecular Biology, Merck Sharp and Dohme Research Laboratories, West Point, Pennsylvania 19486
    J Biol Chem 267:14998-5004. 1992
    ..These results suggest that RAGE functions as a cell surface receptor for AGEs, which could potentially mediate cellular effects of this class of glycosylated proteins...
  6. ncbi Involvement of toll-like receptors 2 and 4 in cellular activation by high mobility group box 1 protein
    Jong Sung Park
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Biol Chem 279:7370-7. 2004
    ..Interactions of HMGB1 with TLR 2 and TLR 4 may provide an explanation for the ability of HMGB1 to generate inflammatory responses that are similar to those initiated by LPS...
  7. ncbi TREM-1 amplifies inflammation and is a crucial mediator of septic shock
    A Bouchon
    Basel Institute for Immunology, Grenzacherstrasse 487, CH 4005 Basel, Switzerland
    Nature 410:1103-7. 2001
    ..These results demonstrate a critical function of TREM-1 in acute inflammatory responses to bacteria and implicate TREM-1 as a potential therapeutic target for septic shock...
  8. ncbi Mechanisms of phagocytosis in macrophages
    A Aderem
    Department of Immunology, University of Washington, Seattle 98195, USA
    Annu Rev Immunol 17:593-623. 1999
    ..Macrophages also play an important role in the recognition and clearance of apoptotic cells; a notable feature of this process is the absence of an inflammatory response...
  9. ncbi HLA and NK cell inhibitory receptor genes in resolving hepatitis C virus infection
    Salim I Khakoo
    Liver Group, Division of Infection, Inflammation, and Repair, Southampton University, Southampton 5016 6YD, UK
    Science 305:872-4. 2004
    ..The data strongly suggest that inhibitory NK cell interactions are important in determining antiviral immunity and that diminished inhibitory responses confer protection against HCV...
  10. ncbi Epistatic interaction between KIR3DS1 and HLA-B delays the progression to AIDS
    Maureen P Martin
    Basic Research Program, SAIC Frederick, Frederick, Maryland 21702 1201, USA
    Nat Genet 31:429-34. 2002
    ..The strongest synergistic effect of these loci was on progression to depletion of CD4(+) T cells, which suggests that a protective response of NK cells involving KIR3DS1 and its HLA class I ligands begins soon after HIV-1 infection...
  11. ncbi Cutting edge: inflammatory responses can be triggered by TREM-1, a novel receptor expressed on neutrophils and monocytes
    A Bouchon
    Basel Institute for Immunology, Basel, Switzerland
    J Immunol 164:4991-5. 2000
    ..To mediate activation, TREM-1 associates with the transmembrane adapter molecule DAP12. Thus, TREM-1 mediates activation of neutrophil and monocytes, and may have a predominant role in inflammatory responses...
  12. ncbi The receptor for advanced glycation end products (RAGE) is a cellular binding site for amphoterin. Mediation of neurite outgrowth and co-expression of rage and amphoterin in the developing nervous system
    O Hori
    Department of Physiology, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
    J Biol Chem 270:25752-61. 1995
    ....
  13. ncbi Natural killer cells in antiviral defense: function and regulation by innate cytokines
    C A Biron
    Department of Molecular Microbiology and Immunology, Brown University, Providence, Rhode Island 02912, USA
    Annu Rev Immunol 17:189-220. 1999
    ....
  14. ncbi Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway
    Masahiro Yamamoto
    Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, 3 1 Yamada oka, Suita Osaka 565 0871, Japan
    Science 301:640-3. 2003
    ..These findings demonstrate that TRIF is essential for TLR3- and TLR4-mediated signaling pathways facilitating mammalian antiviral host defense...
  15. ncbi Toll-like receptors
    Kiyoshi Takeda
    Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Suita Osaka 565 0871, Japan
    Annu Rev Immunol 21:335-76. 2003
    ..The TLR-induced inflammatory response is dependent on a common signaling pathway that is mediated by the adaptor molecule MyD88. However, there is evidence for additional pathways that mediate TLR ligand-specific biological responses...
  16. ncbi Understanding RAGE, the receptor for advanced glycation end products
    Angelika Bierhaus
    J Mol Med (Berl) 83:876-86. 2005
    ..These data suggest that, just as RAGE is a multiligand receptor, its ligands are also likely to recognize several receptors in mediating their biologic effects...
  17. ncbi Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8
    Florian Heil
    Institute of Medical Microbiology, Immunology and Hygiene, Technische Universitat Munchen, Trogerstr 9, D 81675 Munich, Germany
    Science 303:1526-9. 2004
    ..These data suggest that ssRNA represents a physiological ligand for TLR7 and TLR8...
  18. ncbi Human natural killer cells: a unique innate immunoregulatory role for the CD56(bright) subset
    M A Cooper
    Department of Internal Medicine, Division of Hematology/Oncology, The Ohio State University, Columbus, OH, USA
    Blood 97:3146-51. 2001
    ..It is proposed that human CD56(bright) NK cells have a unique functional role in the innate immune response as the primary source of NK cell-derived immunoregulatory cytokines, regulated in part by differential monokine production...
  19. ncbi MHC class I molecules and KIRs in human history, health and survival
    Peter Parham
    Departments of Structural Biology, and Microbiology and Immunology, Stanford University, Stanford, CA 94305, USA
    Nat Rev Immunol 5:201-14. 2005
    ..Such correlations raise the possibility that interplay between KIR and MHC class I polymorphisms has facilitated human survival in the presence of epidemic infections and has influenced both reproduction and population growth...
  20. pmc The DNA damage pathway regulates innate immune system ligands of the NKG2D receptor
    Stephan Gasser
    Department of Molecular and Cell Biology and Cancer Research Laboratory, University of California, Berkeley, California 94720 3200, USA
    Nature 436:1186-90. 2005
    ..Thus, the DNA damage response, previously shown to arrest the cell cycle and enhance DNA repair functions, or to trigger apoptosis, may also participate in alerting the immune system to the presence of potentially dangerous cells...
  21. pmc Rae1 and H60 ligands of the NKG2D receptor stimulate tumour immunity
    A Diefenbach
    Department of Molecular and Cell Biology and Cancer Research Laboratory, University of California, Berkeley 94720, USA
    Nature 413:165-71. 2001
    ....
  22. ncbi Effectiveness of donor natural killer cell alloreactivity in mismatched hematopoietic transplants
    Loredana Ruggeri
    Department of Clinical and Experimental Medicine, Section of Hematology and Clinical Immunology, Perugia University School of Medicine, Perugia, Italy
    Science 295:2097-100. 2002
    ..NK cell alloreactivity may thus provide a powerful tool for enhancing the efficacy and safety of allogeneic hematopoietic transplantation...
  23. ncbi Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3
    L Alexopoulou
    Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut, 06520, USA
    Nature 413:732-8. 2001
    ..Moreover, poly(I:C) can induce activation of NF-kappaB and mitogen-activated protein (MAP) kinases independently of MyD88, and cause dendritic cells to mature...
  24. ncbi S100 proteins expressed in phagocytes: a novel group of damage-associated molecular pattern molecules
    Dirk Foell
    Department of Pediatrics, Institute of Experimental Dermatology, University of Muenster Albert Schweitzer Str 33, Muenster D 48149, Germany
    J Leukoc Biol 81:28-37. 2007
    ....
  25. ncbi High mobility group box chromosomal protein 1 plays a role in the pathogenesis of rheumatoid arthritis as a novel cytokine
    Noboru Taniguchi
    Faculty of Medicine, Kagoshima University, Japan
    Arthritis Rheum 48:971-81. 2003
    ..The purpose of this study was to demonstrate HMGB-1 expression in vivo and to identify the role of HMGB-1 in the pathogenesis of rheumatoid arthritis (RA)...
  26. ncbi Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA
    S Bauer
    Fred Hutchinson Cancer Research Center, Clinical Research Division, 1100 Fairview Avenue North, Seattle, WA 98109, USA
    Science 285:727-9. 1999
    ..These results define an activating immunoreceptor-MHC ligand interaction that may promote antitumor NK and T cell responses...
  27. pmc Mutations in two genes encoding different subunits of a receptor signaling complex result in an identical disease phenotype
    Juha Paloneva
    Department of Molecular Medicine, National Public Health Institute, Helsinki, Finland
    Am J Hum Genet 71:656-62. 2002
    ....
  28. ncbi A Toll-like receptor recognizes bacterial DNA
    H Hemmi
    Department of Host Defense, Research Institute for Microbial Diseases, Osaka University and Core Research for Evolutional Science and Technology, Japan Science and Technology Corporation, Suita
    Nature 408:740-5. 2000
    ..The in vivo CpG-DNA-mediated T-helper type-1 response was also abolished in TLR9-/- mice. Thus, vertebrate immune systems appear to have evolved a specific Toll-like receptor that distinguishes bacterial DNA from self-DNA...
  29. ncbi Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA
    Sandra S Diebold
    Immunobiology Laboratory, Cancer Research UK, London Research Institute, London WC2A 3PX, UK
    Science 303:1529-31. 2004
    ..These results identify ssRNA as a ligand for TLR7 and suggest that cells of the innate immune system sense endosomal ssRNA to detect infection by RNA viruses...
  30. pmc Combinations of maternal KIR and fetal HLA-C genes influence the risk of preeclampsia and reproductive success
    Susan E Hiby
    Department of Pathology, University of Cambridge, Cambridge CB2 1QP, England, UK
    J Exp Med 200:957-65. 2004
    ..In light of our findings, reproductive success may have been a factor in the evolution and maintenance of human HLA-C and KIR polymorphisms...
  31. ncbi IRAK-M is a negative regulator of Toll-like receptor signaling
    Koichi Kobayashi
    Section of Immunobiology, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06510, USA
    Cell 110:191-202. 2002
    ..Endotoxin tolerance, a protection mechanism against endotoxin shock, was significantly reduced in IRAK-M(-/-) cells. Thus, IRAK-M regulates TLR signaling and innate immune homeostasis...
  32. ncbi A soluble form of the receptor for advanced glycation endproducts (RAGE) is produced by proteolytic cleavage of the membrane-bound form by the sheddase a disintegrin and metalloprotease 10 (ADAM10)
    Angela Raucci
    San Raffaele Scientific Institute, Milan, Italy
    FASEB J 22:3716-27. 2008
    ..Our data do not disprove the interpretation that high levels of soluble forms of RAGE protect against chronic inflammation, but rather suggest that they correlate with high levels of ongoing inflammation...
  33. ncbi Activating receptors and coreceptors involved in human natural killer cell-mediated cytolysis
    A Moretta
    Dipartimento di Medicina Sperimentale, Universita degli Studi di Genova, Italy
    Annu Rev Immunol 19:197-223. 2001
    ..Indeed, in patients with the X-linked lymphoproliferative disease, the inability to control Epstein-Barr virus infections may be consequent to a major dysfunction of 2B4 that exerts inhibitory instead of activating functions...
  34. ncbi A role for macrophage scavenger receptors in atherosclerosis and susceptibility to infection
    H Suzuki
    Chugai Pharmaceutical Co Ltd, Shizuoka, Japan
    Nature 386:292-6. 1997
    ..In addition, MSR-A-knockout mice show an increased susceptibility to infection with Listeria monocytogenes or herpes simplex virus type-1, indicating that MSR-A may play a part in host defence against pathogens...
  35. ncbi Tumour-derived soluble MIC ligands impair expression of NKG2D and T-cell activation
    Veronika Groh
    Fred Hutchinson Cancer Research Center, Clinical Research Division, 1100 Fairview Avenue North, Seattle, Washington 98109, USA
    Nature 419:734-8. 2002
    ..This mode of T-cell silencing may promote tumour immune evasion and, by inference, compromise host resistance to infections...
  36. pmc The pattern recognition receptor (RAGE) is a counterreceptor for leukocyte integrins: a novel pathway for inflammatory cell recruitment
    Triantafyllos Chavakis
    Department of Internal Medicine I, University Heidelberg, Bergheimer Strasse 58, D 69115 Heidelberg, Germany
    J Exp Med 198:1507-15. 2003
    ....
  37. ncbi The TREM receptor family and signal integration
    Julia Klesney-Tait
    Washington University School of Medicine, Department of Pathology and Immunology, Saint Louis, Missouri 63110, USA
    Nat Immunol 7:1266-73. 2006
    ..Here we discuss the state of the field, putative ligands of TREM proteins and the challenges that remain in understanding TREM biology...
  38. pmc A common inhibitory receptor for major histocompatibility complex class I molecules on human lymphoid and myelomonocytic cells
    M Colonna
    Basel Institute for Immunology, Basel CH 4005, Switzerland
    J Exp Med 186:1809-18. 1997
    ..These results suggest that diverse leukocyte lineages have adopted recognition of self-MHC class I molecules as a common strategy to control cellular activation during an immune response...
  39. ncbi An activating immunoreceptor complex formed by NKG2D and DAP10
    J Wu
    DNAX Research Institute, 901 California Avenue, Palo Alto, CA 94304, USA
    Science 285:730-2. 1999
    ..Thus, NKG2D-DAP10 receptor complexes may activate NK and T cell responses against MICA-bearing tumors...
  40. ncbi Soluble triggering receptor expressed on myeloid cells and the diagnosis of pneumonia
    Sebastien Gibot
    Service de Reanimation Medicale, Hopital Central, Nancy, France
    N Engl J Med 350:451-8. 2004
    ..The presence of soluble TREM-1 (sTREM-1) in bronchoalveolar-lavage fluid from patients receiving mechanical ventilation may be an indicator of pneumonia...
  41. pmc RAGE signaling sustains inflammation and promotes tumor development
    Christoffer Gebhardt
    Division of Signal Transduction and Growth Control, German Cancer Research Center, 69120 Heidelberg, Germany
    J Exp Med 205:275-85. 2008
    ..We show that RAGE signaling drives the strength and maintenance of an inflammatory reaction during tumor promotion and provide direct genetic evidence for a novel role for RAGE in linking chronic inflammation and cancer...
  42. ncbi Slit proteins bind Robo receptors and have an evolutionarily conserved role in repulsive axon guidance
    K Brose
    Department of Anatomy, Howard Hughes Medical Institute, University of California, San Francisco 94143 0452, USA
    Cell 96:795-806. 1999
    ..These results support the hypothesis that Slit proteins have an evolutionarily conserved role in axon guidance as repulsive ligands for Robo receptors...
  43. ncbi Receptor for advanced glycation end products (RAGE)-mediated neurite outgrowth and activation of NF-kappaB require the cytoplasmic domain of the receptor but different downstream signaling pathways
    H J Huttunen
    Laboratory of Molecular Neurobiology, Institute of Biotechnology, and Department of Biosciences, Division of Biochemistry, University of Helsinki, Finland
    J Biol Chem 274:19919-24. 1999
    ..These data suggest that distinct signaling pathways are used by RAGE to induce neurite outgrowth and regulate gene expression through NF-kappaB...
  44. ncbi Recognition of viral hemagglutinins by NKp44 but not by NKp30
    T I Arnon
    The Lautenberg Center for General and Tumor Immunology, The Hebrew University-Hadassah Medical School, Jerusalem, Israel
    Eur J Immunol 31:2680-9. 2001
    ..221 cells expressing MHC class I proteinsresulted in the abrogation of the inhibition by NK clones expressing high levels of NKp44. In addition, the binding of NKp44 to HA improves the ability of some NK clones to lyse IV infected cells...
  45. ncbi Suppression of accelerated diabetic atherosclerosis by the soluble receptor for advanced glycation endproducts
    L Park
    Department of Surgery, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Nat Med 4:1025-31. 1998
    ....
  46. ncbi TREMs in the immune system and beyond
    Marco Colonna
    Department of Pathology and Immunology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, Missouri 63110, USA
    Nat Rev Immunol 3:445-53. 2003
    ..Remarkably, TREM2 deficiency leads to a severe disease that is characterized by bone cysts and demyelination of the central nervous system, which results in dementia, implying that the function of TREM2 extends beyond the immune system...
  47. ncbi TREM-1 (triggering receptor expressed on myeloid cells): a new player in acute inflammatory responses
    Marco Colonna
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Infect Dis 187:S397-401. 2003
    ..Whatever the ligands, targeted activation or blockade of TREM-1 and its ligands may help maximize the efficacy of existing treatments for sepsis...
  48. ncbi Recognition of haemagglutinins on virus-infected cells by NKp46 activates lysis by human NK cells
    O Mandelboim
    The Lautenberg Center for General and Tumor Immunology, The Hebrew University-Hadassha Medical School, Jerusalem, Israel
    Nature 409:1055-60. 2001
    ..These findings indicate how NKp46-expressing NK cells may recognize target cells infected by influenza or parainfluenza without the decreased expression of target-cell MHC class I protein...
  49. ncbi Costimulation of CD8alphabeta T cells by NKG2D via engagement by MIC induced on virus-infected cells
    V Groh
    Fred Hutchinson Cancer Research Center, Clinical Research Division, Seattle, WA 98109, USA
    Nat Immunol 2:255-60. 2001
    ..Combined triggering of TCR-CD3 complexes and NKG2D induced interleukin 2 production and T cell proliferation. Thus NKG2D functioned as a costimulatory receptor that can substitute for CD28...
  50. ncbi TRAM is specifically involved in the Toll-like receptor 4-mediated MyD88-independent signaling pathway
    Masahiro Yamamoto
    Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, 3 1 Yamada oka, Suita Osaka 565 0871, Japan
    Nat Immunol 4:1144-50. 2003
    ..TLR4- but not TLR3-mediated MyD88-independent interferon-beta production and activation of signaling cascades were abolished in TRAM-deficient cells. Thus, TRAM provides specificity for the MyD88-independent component of TLR4 signaling...
  51. ncbi Tolerization of dendritic cells by T(S) cells: the crucial role of inhibitory receptors ILT3 and ILT4
    C C Chang
    Department of Pathology, Columbia University, New York, NY 10032, USA
    Nat Immunol 3:237-43. 2002
    ..These findings demonstrate an important mechanism of immune regulation...
  52. pmc Plasticity in the organization and sequences of human KIR/ILT gene families
    M J Wilson
    Immunology Division, Department of Pathology, Tennis Court Road, Cambridge CB2 1QP, United Kingdom
    Proc Natl Acad Sci U S A 97:4778-83. 2000
    ..KIR genesis was followed by extensive duplication/deletion as well as intergenic sequence exchange, reminiscent of MHC class I genes, which provide KIR ligands...
  53. ncbi Functionally and structurally distinct NK cell receptor repertoires in the peripheral blood of two human donors
    N M Valiante
    Department of Structural Biology, Stanford University School of Medicine, California 94305, USA
    Immunity 7:739-51. 1997
    ..Because of these differences, the first donor has subpopulations of NK cells that kill cells of the second donor, whereas the NK cells of the second donor are universally tolerant of cells from the first donor...
  54. ncbi Genetic and functional relationships between MHC and NK receptor genes
    J Trowsdale
    Immunology Division, Pathology Department, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, United Kingdom
    Immunity 15:363-74. 2001
    ..1, also have ligands belonging to the extended class I family. The expanding clusters of class I-related sequences and their receptors, some of which evolved recently, reveal further complexity in immune recognition of disease...
  55. ncbi Type I macrophage scavenger receptor contains alpha-helical and collagen-like coiled coils
    T Kodama
    Department of Biology, Massachusetts Institute of Technology, Cambridge 02139
    Nature 343:531-5. 1990
    ..This stalk structure, composed of an alpha-helical coiled coil and a collagen-like triple helix, has not previously been observed in an integral membrane protein...
  56. pmc Donor natural killer cell allorecognition of missing self in haploidentical hematopoietic transplantation for acute myeloid leukemia: challenging its predictive value
    Loredana Ruggeri
    Division of Hematology and Clinical Immunology, Department of Clinical and Experimental Medicine, University of Perugia, Istituto di Ricovero e Cura a Carattere Scientifico, Foundation on Transplantation Biotechnologies, Perugia, Italy
    Blood 110:433-40. 2007
    ..Only transplantation from NK-alloreactive donors is associated with a survival advantage...
  57. ncbi Release of high mobility group box 1 by dendritic cells controls T cell activation via the receptor for advanced glycation end products
    Ingrid E Dumitriu
    Cancer Immunotherapy and Gene Therapy Program, Clinical Immunology Unit, H San Raffaele Scientific Institute, Milan, Italy
    J Immunol 174:7506-15. 2005
    ..The use of an ancient signal of necrosis, HMGB1, by dendritic cells to sustain their own maturation and for activation of T lymphocytes represents a profitable evolutionary mechanism...
  58. pmc Vascular and inflammatory stresses mediate atherosclerosis via RAGE and its ligands in apoE-/- mice
    Evis Harja
    Division of Surgical Science, Department of Surgery, Columbia University Medical Center, New York, New York 10032, USA
    J Clin Invest 118:183-94. 2008
    ..These data highlight unifying mechanisms whereby endothelial RAGE and its ligands mediate vascular and inflammatory stresses that culminate in atherosclerosis in the vulnerable vessel wall...
  59. ncbi A role for triggering receptor expressed on myeloid cells-1 in host defense during the early-induced and adaptive phases of the immune response
    Joshua R Bleharski
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    J Immunol 170:3812-8. 2003
    ..Our data suggest that activation of TREM-1 on monocytes participates during the early-induced and adaptive immune responses involved in host defense against microbial challenges...
  60. ncbi Roles of the NKG2D immunoreceptor and its ligands
    David H Raulet
    Department of Molecular and Cell Biology and Cancer Research Laboratory, University of California, Berkeley, California 94720 3200, USA
    Nat Rev Immunol 3:781-90. 2003
    ....
  61. ncbi Costimulatory signals mediated by the ITAM motif cooperate with RANKL for bone homeostasis
    Takako Koga
    Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 0033, Japan
    Nature 428:758-63. 2004
    ..These results reveal that RANKL and M-CSF are not sufficient to activate the signals required for osteoclastogenesis...
  62. ncbi IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling
    M Muzio
    University of Michigan Medical School, Department of Pathology, Ann Arbor, MI 48109, USA
    Science 278:1612-5. 1997
    ..Dominant negative forms of either attenuate IL-1R-mediated NF-kappaB activation. Therefore, IRAK-2 and MyD88 may provide additional therapeutic targets for inhibiting IL-1-induced inflammation...
  63. pmc Receptor for advanced glycation end products (RAGE) regulates sepsis but not the adaptive immune response
    Birgit Liliensiek
    Department of Molecular Immunology, Division of Tumor Immunology, German Cancer Research Center, Heidelberg, Germany
    J Clin Invest 113:1641-50. 2004
    ..These results indicate that the innate immune response is controlled by pattern-recognition receptors not only at the initiating steps but also at the phase of perpetuation...
  64. ncbi Natural killer cell signaling pathways
    Eric Vivier
    Centre d immunologie de Marseille Luminy, INSERM CNRS Univ Méditerranée, Campus de Luminy, Case 906, 13288 Marseille Cedex 09, France
    Science 306:1517-9. 2004
    ..Understanding the integration of these multiple signals is central to the understanding and manipulation of NK cell effector signaling pathways...
  65. ncbi The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors
    Tiffany Horng
    Howard Hughes Medical Institute, Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Nature 420:329-33. 2002
    ..Thus, TIRAP is differentially involved in signalling by members of the TLR family and may account for specificity in the downstream signalling of individual TLRs...
  66. ncbi Hydrophobicity: an ancient damage-associated molecular pattern that initiates innate immune responses
    Seung Yong Seong
    Ghost Lab, Laboratory of Cellular and Molecular Immunology, National Insstitute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Nat Rev Immunol 4:469-78. 2004
  67. ncbi Isolation and characterization of two binding proteins for advanced glycosylation end products from bovine lung which are present on the endothelial cell surface
    A M Schmidt
    Department of Physiology and Cellular Biophysics, Columbia University College of Physicians and Surgeons, New York, New York 10032
    J Biol Chem 267:14987-97. 1992
    ..These polypeptides represent a novel class of cell surface acceptor molecules for glucose-modified proteins which may promote degradation and/or transcytosis of the ligand, and modulation of cellular function...
  68. ncbi Loss-of-function mutations in TYROBP (DAP12) result in a presenile dementia with bone cysts
    J Paloneva
    Department of Human Molecular Genetics, National Public Health Institute, Helsinki, Finland
    Nat Genet 25:357-61. 2000
    ..No abnormalities in NK cell function were detected in PLOSL patients homozygous for a null allele of TYROBP...
  69. pmc A human histocompatibility leukocyte antigen (HLA)-G-specific receptor expressed on all natural killer cells
    S Rajagopalan
    Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland 20852, USA
    J Exp Med 189:1093-100. 1999
    ..Therefore, given that HLA-G expression is restricted to fetal trophoblast cells, KIR2DL4 may provide important signals to maternal NK decidual cells that interact with trophoblast cells at the maternal-fetal interface during pregnancy...
  70. ncbi The SIRP family of receptors and immune regulation
    A Neil Barclay
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK
    Nat Rev Immunol 6:457-64. 2006
    ..In this Review, we describe recent studies defining the ligands of the SIRP-family members, with particular emphasis on relating the molecular interactions of these proteins to their role in immune-cell regulation...
  71. ncbi Mechanisms of disease: advanced glycation end-products and their receptor in inflammation and diabetes complications
    Shi Fang Yan
    Division of Surgical Science, Department of Surgery, Columbia University Medical Center, New York, NY 10032, USA
    Nat Clin Pract Endocrinol Metab 4:285-93. 2008
    ....
  72. pmc Unravelling natural killer cell function: triggering and inhibitory human NK receptors
    Lorenzo Moretta
    Istituto Giannina Gaslini, Genova Quarto, Italy
    EMBO J 23:255-9. 2004
    ..Thus, the ability of NK cells to lyse target cells requires both the lack of surface MHC class I molecules and the expression of appropriate ligands that trigger NK receptors...
  73. pmc RAGE drives the development of glomerulosclerosis and implicates podocyte activation in the pathogenesis of diabetic nephropathy
    Thoralf M Wendt
    Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Am J Pathol 162:1123-37. 2003
    ....
  74. ncbi Human diversity in killer cell inhibitory receptor genes
    M Uhrberg
    Department of Structural Biology, Stanford University School of Medicine, California 94305, USA
    Immunity 7:753-63. 1997
    ..Group B comprises more noninhibitory KIR genes and contains at least one additional gene not represented in group A. The KIR locus therefore appears to be polygenic and polymorphic within the human population...
  75. ncbi KIR: diverse, rapidly evolving receptors of innate and adaptive immunity
    Carlos Vilches
    Servicio de Inmunologia, Hospital Universitario Clinica Puerta de Hierro, San Martin de Porres 4, 28035 Madrid, Spain
    Annu Rev Immunol 20:217-51. 2002
    ..This diversity likely contributes variability to the function of NK cells and T-lymphocytes by modulating innate and adaptive immune responses to specific challenges...
  76. pmc Prostaglandin D2 selectively induces chemotaxis in T helper type 2 cells, eosinophils, and basophils via seven-transmembrane receptor CRTH2
    H Hirai
    R and D Center, BML, Saitama 350 1101, Japan
    J Exp Med 193:255-61. 2001
    ..In addition, CRTH2, but not DP, mediates PGD2-dependent cell migration of blood eosinophils and basophils. Thus, PGD2 is likely involved in multiple aspects of allergic inflammation through its dual receptor systems, DP and CRTH2...
  77. ncbi The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5
    F Hayashi
    Department of Immunology, University of Washington, Seattle 98195, USA
    Nature 410:1099-103. 2001
    ..Our data suggest that TLR5, a member of the evolutionarily conserved Toll-like receptor family, has evolved to permit mammals specifically to detect flagellated bacterial pathogens...
  78. ncbi Toll-like receptor signalling
    Shizuo Akira
    Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, and ERATO, Japan Science and Technology Agency, 3 1 Yamada oka, Suita, Osaka 565 0871, Japan
    Nat Rev Immunol 4:499-511. 2004
  79. pmc Human decidual natural killer cells are a unique NK cell subset with immunomodulatory potential
    Louise A Koopman
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    J Exp Med 198:1201-12. 2003
    ..Additionally, two secreted proteins, galectin-1 and progestagen-associated protein 14, known to have immunomodulatory functions, were selectively expressed in dNK cells...
  80. pmc NKp44, a novel triggering surface molecule specifically expressed by activated natural killer cells, is involved in non-major histocompatibility complex-restricted tumor cell lysis
    M Vitale
    Istituto Nazionale per la Ricerca sul Cancro and Centro Biotecnologie Avanzate, 16132 Genova, Italy
    J Exp Med 187:2065-72. 1998
    ....
  81. pmc Hierarchy of resistance to cervical neoplasia mediated by combinations of killer immunoglobulin-like receptor and human leukocyte antigen loci
    Mary Carrington
    Basic Research Program, Laboratory of Genomic Diversity, Science Applications International Corporation Frederick, Inc, National Cancer Institute, Frederick, MD 21702, USA
    J Exp Med 201:1069-75. 2005
    ....
  82. ncbi Innate immune recognition
    Charles A Janeway
    Section of Immunobiology and Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut 06520 8011, USA
    Annu Rev Immunol 20:197-216. 2002
    ..Thus, microbial recognition by Toll-like receptors helps to direct adaptive immune responses to antigens derived from microbial pathogens...
  83. ncbi Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway
    Hiroaki Hemmi
    Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, 3 1 Yamada oka, Suita, Osaka 565 0871, Japan
    Nat Immunol 3:196-200. 2002
    ..Imidazoquinoline-induced signaling events were also abolished in both MyD88- and TLR7-deficient mice...
  84. pmc S100A8/A9 at low concentration promotes tumor cell growth via RAGE ligation and MAP kinase-dependent pathway
    Saeid Ghavami
    Manitoba Institute of Cell Biology and Department of Biochemistry and Medical Genetics, University of Manitoba, Winnipeg, MB, Canada
    J Leukoc Biol 83:1484-92. 2008
    ..RAGE small interfering RNA pretreatment abrogated the S100A8/A9-induced NF-kappaB activation. Our data indicate that S100A8/A9-promoted cell growth occurs through RAGE signaling and activation of NF-kappaB...
  85. ncbi Inhibition of the NKp30 activating receptor by pp65 of human cytomegalovirus
    Tal I Arnon
    The Lautenberg Center for General and Tumor Immunology, The Hebrew University Hadassah Medical School, Jerusalem 91120, Israel
    Nat Immunol 6:515-23. 2005
    ..Thus, pp65 is a ligand for the NKp30 receptor and demonstrates a unique mechanism by which an intracellular viral protein causes general suppression of natural killer cell cytotoxicity by specific interaction with an activating receptor...
  86. ncbi RAGE blockade stabilizes established atherosclerosis in diabetic apolipoprotein E-null mice
    Loredana G Bucciarelli
    Division of Surgical Science, College of Physicians and Surgeons, Department of Surgery, Columbia University, New York, NY 10032, USA
    Circulation 106:2827-35. 2002
    ..In this study, we tested the hypothesis that RAGE contributed to lesion progression in established atherosclerosis in diabetic apoE-null mice...
  87. pmc p46, a novel natural killer cell-specific surface molecule that mediates cell activation
    S Sivori
    Istituto di Istologia ed Embriologia Generale, Universita di Genova, Genova, Italy
    J Exp Med 186:1129-36. 1997
    ..Both the unique cellular distribution and functional capability of p46 molecules suggest a possible role in the mechanisms of non-major histocompatibility complex-restricted cytolysis mediated by human NK cells...
  88. ncbi Involvement of microglial receptor for advanced glycation endproducts (RAGE) in Alzheimer's disease: identification of a cellular activation mechanism
    L F Lue
    The Roberts Alzheimer s Disease Center, Sun Health Research Institute, Sun City, Arizona 85372, USA
    Exp Neurol 171:29-45. 2001
    ..These data suggest a positive feedback loop in which Abeta-RAGE-mediated microglial activation enhances expression of M-CSF and RAGE, possibly initiating an ascending spiral of cellular activation...
  89. ncbi A novel immunoglobulin superfamily receptor for cellular and viral MHC class I molecules
    D Cosman
    Immunex Corporation, Seattle, Washington 98101, USA
    Immunity 7:273-82. 1997
    ..Upon tyrosine phosphorylation, LIR-1 associates with the tyrosine phosphatase SHP-1. In contrast to KIRs, LIR-1 is expressed predominantly on monocytic and B lymphoid cell types, suggesting a distinct biological function...
  90. ncbi Cutting edge: susceptibility to psoriatic arthritis: influence of activating killer Ig-like receptor genes in the absence of specific HLA-C alleles
    Maureen P Martin
    Basic Research Program, SAIC Frederick, MD 21702, USA
    J Immunol 169:2818-22. 2002
    ..Absence of ligands for inhibitory KIRs could potentially lower the threshold for NK (and/or T) cell activation mediated through activating receptors, thereby contributing to pathogenesis of psoriatic arthritis...
  91. ncbi Conserved roles for Slit and Robo proteins in midline commissural axon guidance
    Hua Long
    Howard Hughes Medical Institute, Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA
    Neuron 42:213-23. 2004
    ..These results demonstrate a key role for Slit/Robo signaling in midline commissural axon guidance in vertebrates...
  92. ncbi Molecular basis for positive and negative signaling by the natural killer cell receptor 2B4 (CD244)
    Philipp Eissmann
    Institute for Immunology, University Heidelberg, Germany
    Blood 105:4722-9. 2005
    ..We now show that Fyn can also associate with phosphorylated 2B4. Finally, we demonstrate that Fyn and Csk can both phosphorylate 2B4, suggesting a possible mechanism of 2B4 phosphorylation...
  93. ncbi Advanced glycation end products activate endothelium through signal-transduction receptor RAGE: a mechanism for amplification of inflammatory responses
    Giuseppina Basta
    CNR Institute of Clinical Physiology, Pisa, Italy
    Circulation 105:816-22. 2002
    ..A principal means by which AGEs alter cellular properties is through interaction with their signal-transduction receptor RAGE. We tested the hypothesis that interaction of AGEs with RAGE on endothelial cells enhances vascular activation...
  94. ncbi The killer cell immunoglobulin-like receptor (KIR) genomic region: gene-order, haplotypes and allelic polymorphism
    Katharine C Hsu
    Immunology Program, Sloan Kettering Institute for Cancer Research, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Immunol Rev 190:40-52. 2002
    ..Recent application of immunogenetic analysis of KIR genes in patient populations implicates these genes as important genetic disease susceptibility factors...
  95. pmc Toll-like receptor 9-mediated recognition of Herpes simplex virus-2 by plasmacytoid dendritic cells
    Jennifer Lund
    Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    J Exp Med 198:513-20. 2003
    ..Therefore, these results demonstrate a novel mechanism whereby the genomic DNA of a virus can engage TLR9 and result in the secretion of IFN-alpha by pDCs...
  96. ncbi HLA-G and immune tolerance in pregnancy
    Joan S Hunt
    Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, Kansas 66160 7400, USA
    FASEB J 19:681-93. 2005
    ....
  97. pmc Receptor for advanced glycation end-products is a marker of type I cell injury in acute lung injury
    Tokujiro Uchida
    Department of Anesthesiology, Graduate School of Medicine, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Am J Respir Crit Care Med 173:1008-15. 2006
    ..Receptor for advanced glycation end-products (RAGE) is one of the alveolar type I cell-associated proteins in the lung...
  98. ncbi Natural killer cells, viruses and cancer
    A Cerwenka
    Department of Microbiology and Immunology and the Cancer Research Institute, University of California, San Francisco, 94143-0414, USA
    Nat Rev Immunol 1:41-9. 2001
    ..Here, we review the emerging evidence that natural killer cells have an important role in vivo in immune defence...
  99. ncbi Killer Ig-like receptor haplotype analysis by gene content: evidence for genomic diversity with a minimum of six basic framework haplotypes, each with multiple subsets
    Katharine C Hsu
    Immunology Program, Sloan Kettering Institute for Cancer Research, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Immunol 169:5118-29. 2002
    ..Additional rare haplotypes can be identified, and may have arisen by gene duplication, intergenic recombination, or deletions...
  100. pmc NTB-A [correction of GNTB-A], a novel SH2D1A-associated surface molecule contributing to the inability of natural killer cells to kill Epstein-Barr virus-infected B cells in X-linked lymphoproliferative disease
    C Bottino
    Istituto Nazionale per la Ricerca sul Cancro, 16132 Genoa, Italy
    J Exp Med 194:235-46. 2001
    ..Thus, the altered function of NTB-A appears to play an important role in the inability of XLP-NK cells to kill EBV-infected target cells...
  101. ncbi Cloning of a novel bacteria-binding receptor structurally related to scavenger receptors and expressed in a subset of macrophages
    O Elomaa
    Biocenter Oulu, University of Oulu, Finland
    Cell 80:603-9. 1995
    ....

Research Grants64

  1. COMPLEMENT RECEPTORS ON MURINE KUPFFER CELLS
    Francis Moore; Fiscal Year: 1991
    ..cells (hepatic macrophages) clear soluble antigens and bacteria is presumed to involve cell surface immunologic receptors that recognize opsonins coating those targets...
  2. Iron Deficiency and Anemia in HIV and HCV-Infected Women
    Richard Semba; Fiscal Year: 2005
    ..S. and elsewhere. ..
  3. NK Receptors and Bone Marrow Transplant Outcome
    Katharine Hsu; Fiscal Year: 2008
    ..Dr. Hsu intends to develop a career as an independent investigator in the field of NK cell immunogenetics and allogeneic hematopoietic stem cell transplantation. ..
  4. NK CELL RECEPTORS AND THEIR LIGANDS
    LEWIS LANIER; Fiscal Year: 2005
    ..These studies promise to provide new insights into the role of innate immunity in protection against pathogens and cancer. ..
  5. NK AND T CELL COSTIMULATION BY NKG2D/DAP10
    LEWIS LANIER; Fiscal Year: 2005
    ..Given the broad distribution of MICA/B on freshly isolated human tumors, studies of the NKG2D-DAP10 receptor may provide new opportunities for immunotherapeutic intervention in cancer. ..
  6. ADJUNCT VITAMIN A THERAPY FOR TUBERCULOSIS AND HIV/AIDS
    Richard Semba; Fiscal Year: 2005
    ....
  7. Oxidative Stress and the Pathogenesis of Sarcopenia and Disability in Older Women
    Richard Semba; Fiscal Year: 2008
    ..AGEs are a potentially modifiable risk factor, as circulating AGEs can be lowered by dietary modification and by pharmacological intervention. ..
  8. Hepcidin and the pathogenesis of anemia in older adults.
    Richard D Semba; Fiscal Year: 2010
    ..This study should provide new insight into the epidemiology and biological mechanisms of anemia among older adults and help identify strategies aimed at the prevention and treatment of anemia. ..
  9. MICRONUTRIENTS AND MOTHER TO CHILD TRANSMISSION OF HIV
    Richard Semba; Fiscal Year: 2001
    ..The relationship between mastitis and breastmilk HIV load and the epidemiology and microbiology of mastitis will be examined in a new cohort of HIV-infected lactating women. ..
  10. Biology of Leukocyte Regulatory Receptor
    LEWIS LANIER; Fiscal Year: 2002
    ..This represents the first conference to bring together investigators with a focus on structure, signaling, and in vivo biology of Leukocyte Regulatory Receptor function. ..
  11. VITAMIN A SUPPLEMENTATION FOR HIV INFECTED CHILDREN
    Richard Semba; Fiscal Year: 2002
    ....
  12. Conference on Innate Immunity to Pathogens
    Wayne Yokoyama; Fiscal Year: 2005
    ..abstract_text> ..
  13. AGING AND VASCULAR DISEASE: ROLE OF GLYCATION
    Helen Vlassara; Fiscal Year: 2007
    ..diabetes, diet. The proposed studies will expand our understanding of this basic process and may allow us to identify ways to prevent AGE-induced vascular injury due to diabetes and aging. ..
  14. Alzheimer's ABeta, Apolipoproteins & Blood-Brain Barrier
    Berislav Zlokovic; Fiscal Year: 2004
    ....
  15. TLR4 as an LPS sendor and susceptibility locus
    Bruce Beutler; Fiscal Year: 2007
    ..The new mutations that are found--and those that have already been found in preliminary efforts--will be isolated by positional cloning. ..
  16. The regulation of tumor immunity by NKT cells
    Mark Smyth; Fiscal Year: 2007
    ..This proposal focuses clearly on a pivotal immune control mechanism that will influence many current and future immunotherapies. ..
  17. Immunological Monitoring of Heart Allograft Recipients
    Nicole Suciu Foca; Fiscal Year: 2006
    ....
  18. Conference of the Society for Natural Immunity
    Wayne Yokoyama; Fiscal Year: 2005
    ..abstract_text> ..
  19. Vascular Response and Glycoxidant Homeostasis
    Helen Vlassara; Fiscal Year: 2009
    ..The elucidation of AGER1 mechanisms, which influence the regulation of AGE clearance (positively) and/or the pro-OS, inflammatory pathways (negatively) may generate new therapeutic targets against human vascular disease. ..
  20. RAGE and a Novel Tumor Axis
    Ann Schmidt; Fiscal Year: 2005
    ....
  21. Genes that Mediate Tolerance to the Placental Allograft
    Bruce Beutler; Fiscal Year: 2006
    ..Fourth, circumvention of the toleragenic mechanism might be used to prevent normal gestation, leading to termination of pregnancy within a few days following implantation of the blastocyst. ..
  22. Forward Genetic Analysis of the Innate Immune Contribution to MCMV Resistance
    Bruce Beutler; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  23. Linking Innate with Adaptive Immune Response
    Wayne Yokoyama; Fiscal Year: 2003
    ..This meeting will be especially rewarding for students and postdoctoral fellows in search of opportunities for future research and challenges. ..
  24. AGE-RECEPTORS AND KIDNEY DISEASE
    Helen Vlassara; Fiscal Year: 2003
    ....
  25. AGING BRAIN--CEREBROVASCULAR MECHANISM & AMYLOID BETA
    Berislav Zlokovic; Fiscal Year: 2003
    ..abstract_text> ..
  26. Protein S: Neurovascular Protection in Stroke
    Berislav V Zlokovic; Fiscal Year: 2010
    ..B. Berk (Rochester) (Tyro 3 RTK-Akt signaling) and Dr. M. Chopp (Henry Ford) (rat stroke model). The results will provide mechanistic insights and test therapeutic agents that may be translated to improved therapy for ischemic stroke. ..
  27. Mutagenic analysis of LPS responses
    Bruce Beutler; Fiscal Year: 2006
    ..In the case of mutations that abolish LPS tolerance, we will attempt to determine the net impact on host resistance to infection. ..
  28. BIOLOGY OF HUMAN UTERINE NK CELLS
    Ashley Moffett; Fiscal Year: 2004
    ..It could lead to novel therapeutic approaches in a wide range of disorders including infertility, miscarriage, disorders due to defective placentation (pre-eclampsia and IUGR) and menstrual disorders. ..
  29. REGULATORY T CELLS IN ALLORECOGNITION
    Nicole Suciu Foca; Fiscal Year: 2004
    ..An animal model for induction of tolerance by transfer of Ts will be used. These studies will establish the role of allospecific Ts and their potential use for tolerance induction. ..
  30. EXPRESSION, SPECIFICITY, AND FUNCTION OF LY49 FAMILY
    Wayne Yokoyama; Fiscal Year: 2001
    ..Thus, these studies will provide fundamental new information that will further elucidate the function of NK cells and their tolerance mechanisms. ..
  31. B Cells and Development of Intestinal Epithelium
    Alexander Chervonsky; Fiscal Year: 2005
    ..These mechanisms are critical for protection against pathogens and development of oral vaccines. ..
  32. Biased Thymic Selection and Consequential Autoimmunity
    Alexander Chervonsky; Fiscal Year: 2005
    ..The significance of the proposed research program is that it links together the expression of biased MEC-peptide repertoire, selection of altered T-cell repertoire, and resultant autoimmunity. ..
  33. Genetic Control of Homing of Autoimmune T Cells
    Alexander Chervonsky; Fiscal Year: 2008
    ..Identification of the genes involved will provide us with crucial information on what molecular pathways are engaged and will allow further elucidation of the homing of autoimmune T cells. ..
  34. The Functional of TREM-1 in Sepsis
    Marco Colonna; Fiscal Year: 2010
    ..We also have detected a binding partner of TREM-1 (the TREM-1 ligand) and we propose to identify this molecule as it may serve as a novel target for the treatment of septic patients, ..
  35. Early Forms of Oxidized LDL, TLRs and Atherosclerosis
    Yury Miller; Fiscal Year: 2010
    ..Because the oxidized moieties in mmLDL are likely to be common components of oxidized membranes in general, these studies are likely to have generalized importance. ..
  36. Regulation of normal human IEL by NKG2D and IL-15
    Bana Jabri; Fiscal Year: 2010
    ....
  37. THE GENETIC & FUNCTIONAL ANATOMICAL BASIS OF HGPPS
    Joanna Jen; Fiscal Year: 2009
    ..Understanding the anatomical and molecular basis of HGPPS will provide insight into the genetically programmed neurodevelopment of the conjugate horizontal gaze center and other cranial nuclei in the brainstem. ..
  38. Ethanols role in mediation of monocyte suppression
    Gyongyi Szabo; Fiscal Year: 2009
    ..Investigation of the modulation of IL-10 and IL-12 by alcohol in dendritic cell function may identify biomarkers of alcohol-induced immune depression and reveal potential targets for therapy. ..
  39. QMS Technology to Deplete T Cell Alloreactivity
    Sherif Farag; Fiscal Year: 2008
    ..abstract_text> ..
  40. Pathobiology of Retinal Vasculopathy with Cerebal Leukodystrophy (RVCL)
    Joanna C Jen; Fiscal Year: 2010
    ..abstract_text> ..
  41. Plasmacytoid Dendritic Cells in Anti-Tumor Response
    Marco Colonna; Fiscal Year: 2008
    ..These findings also substantiate the physiological relevance of the proposed studies to clinical human cancer situations. ..
  42. Genetics of Familial Episodic Ataxia
    Joanna C Jen; Fiscal Year: 2010
    ..Insights gained from the study will lead to improved diagnosis and treatment of familial episodic ataxia and the more common episodic vertigo syndromes. ..
  43. Hepatitis C Virus, Alcohol and Host Defense
    Gyongyi Szabo; Fiscal Year: 2007
    ..Results from these studies should reveal molecular and cellular mechanisms by which alcohol interacts with HCV infection to accelerate disease persistence and progression. [unreadable] [unreadable]..
  44. Immune Defense: The Role of NKG2D/DAP10
    Marco Colonna; Fiscal Year: 2007
    ..abstract_text> ..
  45. ENHANCING COLLECTIN MEDIATED HOST DEFENSE
    Kevan Hartshorn; Fiscal Year: 2001
    ..These experiments should yield important insights into basic collection biology and demonstrate that enhancement of collectin-mediated pulmonary host defense can be achieved in vivo through rational alteration of wild type collectins. ..
  46. MUTATIONS IN CALCIUM CHANNELS CAUSING VERTIGO AND ATAXIA
    Joanna Jen; Fiscal Year: 2002
    ..The further relevance of this work to the more common basilar migraine and Meniere's syndrome is emphasized by the overlapping symptoms of vertigo and ataxia in the group of patients that we propose to study. ..
  47. OPTIMIZING BMT FOR CANCER BY GENETIC MATCHING OF DONORS
    Effie Petersdorf; Fiscal Year: 2003
    ....
  48. Innate Immune Cell Therapy with Stem Cell Transplants
    Sherif Farag; Fiscal Year: 2003
    ..The clinical and laboratory data derived from this trial will form the basis for future phase II studies to investigate the efficacy of this immunotherapy approach. ..
  49. NUCLEOTIDE DONORS AFFECTING GLYCOSYLATION PATHWAYS
    Ajit Varki; Fiscal Year: 2003
    ....
  50. Role of Innate Immunity in Type 1 Diabetes
    Alexander Chervonsky; Fiscal Year: 2003
    ..The results of these studies should help to address a fundamental issue - the role of the Toll pathway in the mechanism of an autoimmune disease. ..
  51. S100B Transgenic Mice and AMD
    Kimberly Howes; Fiscal Year: 2004
    ..abstract_text> ..
  52. SNPs in Lung Cancer Risk and Therapeutic Response
    Effie Petersdorf; Fiscal Year: 2004
    ..abstract_text> ..
  53. NK Cell Recognition of Leukemia Blasts and IL-2 Therapy
    Sherif Farag; Fiscal Year: 2004
    ..The results of our studies may provide a means of identifying which subset of AML cases are susceptible to IL-2 therapy, and therefore, may ultimately assist in the better selection of patients for NK cell-based therapies. ..
  54. Workshop on Antigen Processing and Presentation
    Alexander Chervonsky; Fiscal Year: 2004
    ..This meeting has been held every two years since 1994 and continues to be unique and productive. ..
  55. DECIDUAL CELL/PLACENTAL INTERACTIONS
    JOAN HUNT; Fiscal Year: 2007
    ..abstract_text> ..
  56. International Conference on Episodic Ataxia Syndromes
    Joanna Jen; Fiscal Year: 2005
    ..abstract_text> ..
  57. MHC Class l-independent NK Cell Regulation
    Koho Iizuka; Fiscal Year: 2006
    ..2) Determine the role of Nkrpl/Clr genes in NK cell development. These studies are critical to our understanding of innate immunity and improving the manipulation of NK cells for therapeutic purposes. ..
  58. mTOR Inhibition as a Therapeutic Target in Myeloma
    Sherif Farag; Fiscal Year: 2005
    ..The results of this research have important significance for the treatment of MM and may lead to a novel therapeutic approach in this disease. ..
  59. Chemokines, nitric oxide, and myocardial depression
    Bysani Chandrasekar; Fiscal Year: 2005
    ..The results from these studies will further our knowledge of chemokine biology and lead to new therapeutic strategies to prevent or treat myocardial dysfunction in ischemia-reperfusion injury. ..
  60. Mechanisms of Alcohol Mediated Organ and Tissue Damage
    Gyongyi Szabo; Fiscal Year: 2005
    ..3. Increase the involvement of young investigators in the study of alcohol research. 4. Provide an educational forum to participants. ..
  61. Natural IgM antilymphocyte autoantibodies inhibit HIV-1
    PETER LOBO; Fiscal Year: 2003
    ..A successful outcome with the proposed studies could better our understanding on pathogenesis of H1V-1 infection and may provide strategies to prolong the asymptomatic state after HIV-1 infection. ..
  62. Estrogen and Mechanisms of Cardiomyocyte Protection
    Richard Karas; Fiscal Year: 2009
    ....