serotonin receptors

Summary

Summary: Cell-surface proteins that bind SEROTONIN and trigger intracellular changes which influence the behavior of cells. Several types of serotonin receptors have been recognized which differ in their pharmacology, molecular biology, and mode of action.

Top Publications

  1. ncbi A review of central 5-HT receptors and their function
    N M Barnes
    Department of Pharmacology, The Medical School, University of Birmingham, Edgbaston, UK
    Neuropharmacology 38:1083-152. 1999
  2. pmc The bovine mammary gland expresses multiple functional isoforms of serotonin receptors
    Laura L Hernandez
    Department of Animal Sciences, University of Arizona, Tucson, Arizona 85721, USA
    J Endocrinol 203:123-31. 2009
  3. ncbi The role of serotonin (5-hydroxytryptamine1A and 1B) receptors in prostate cancer cell proliferation
    Emad J Siddiqui
    Department of Urology, Royal Free Hospital and University College Medical School, University College, London, United Kingdom
    J Urol 176:1648-53. 2006
  4. ncbi Multiplicity of mechanisms of serotonin receptor signal transduction
    J R Raymond
    The Research Service of the Ralph H Johnson Veterans Affairs Medical Center, Charleston, SC 29401, USA
    Pharmacol Ther 92:179-212. 2001
  5. ncbi Segregation of serotonin 5-HT2A and 5-HT3 receptors in inhibitory circuits of the primate cerebral cortex
    R L Jakab
    Section of Neurobiology, Yale University, School of Medicine, New Haven, CT 06520 8001, USA
    J Comp Neurol 417:337-48. 2000
  6. doi Evaluation of serotonin as a feedback inhibitor of lactation in the bovine
    L L Hernandez
    Department of Animal Sciences, University of Arizona, Tucson 85721, USA
    J Dairy Sci 91:1834-44. 2008
  7. ncbi Review article: serotonin receptors and transporters -- roles in normal and abnormal gastrointestinal motility
    M D Gershon
    Department of Anatomy and Cell Biology, Columbia University, New York, NY 10032, USA
    Aliment Pharmacol Ther 20:3-14. 2004
  8. pmc Spinal 5-HT(2) and 5-HT(3) receptors mediate low, but not high, frequency TENS-induced antihyperalgesia in rats
    Rajan Radhakrishnan
    Graduate Program in Physical Therapy and Rehabilitation Science, College of Medicine 1 252 Medical Education Building, University of Iowa, Iowa City, IA 52242 1190, USA
    Pain 105:205-13. 2003
  9. ncbi Serotonin signaling is a very early step in patterning of the left-right axis in chick and frog embryos
    Takahiro Fukumoto
    Cytokine Biology Department, The Forsyth Institute and Department of Oral and Developmental Biology, Harvard Medical School, 140 The Fenway, Boston, Massachusetts 02115, USA
    Curr Biol 15:794-803. 2005
  10. ncbi Importance of phenylalanine 107 in agonist recognition by the 5-hydroxytryptamine(3A) receptor
    L J Steward
    Yoshitomi Research Institute of Neuroscience in Glasgow, University of Glasgow, United Kingdom
    Mol Pharmacol 57:1249-55. 2000

Detail Information

Publications289 found, 100 shown here

  1. ncbi A review of central 5-HT receptors and their function
    N M Barnes
    Department of Pharmacology, The Medical School, University of Birmingham, Edgbaston, UK
    Neuropharmacology 38:1083-152. 1999
    ..In support of which, a number of 5-HT receptor ligands are currently utilised, or are in clinical development, to reduce the symptoms of CNS dysfunction...
  2. pmc The bovine mammary gland expresses multiple functional isoforms of serotonin receptors
    Laura L Hernandez
    Department of Animal Sciences, University of Arizona, Tucson, Arizona 85721, USA
    J Endocrinol 203:123-31. 2009
    ..Whereas human and mouse mammary epithelial cells express predominately the protein for the 5-HT(7) receptor, cow mammary epithelium expresses multiple receptors that have overlapping, but not identical, functional activities...
  3. ncbi The role of serotonin (5-hydroxytryptamine1A and 1B) receptors in prostate cancer cell proliferation
    Emad J Siddiqui
    Department of Urology, Royal Free Hospital and University College Medical School, University College, London, United Kingdom
    J Urol 176:1648-53. 2006
    ....
  4. ncbi Multiplicity of mechanisms of serotonin receptor signal transduction
    J R Raymond
    The Research Service of the Ralph H Johnson Veterans Affairs Medical Center, Charleston, SC 29401, USA
    Pharmacol Ther 92:179-212. 2001
    ..This review will focus on what is known about the signaling linkages of the G-protein-linked 5-HT receptors, and will highlight some fascinating new insights into 5-HT receptor signaling...
  5. ncbi Segregation of serotonin 5-HT2A and 5-HT3 receptors in inhibitory circuits of the primate cerebral cortex
    R L Jakab
    Section of Neurobiology, Yale University, School of Medicine, New Haven, CT 06520 8001, USA
    J Comp Neurol 417:337-48. 2000
    ..This cellular segregation indicates a serotonin-receptor-specific segmentation of the GABAergic inhibitory actions along the pyramidal neuron tree...
  6. doi Evaluation of serotonin as a feedback inhibitor of lactation in the bovine
    L L Hernandez
    Department of Animal Sciences, University of Arizona, Tucson 85721, USA
    J Dairy Sci 91:1834-44. 2008
    ..Doses of 5-HT and METH used in this study likely resulted in systemic effects. These data support the concept that 5-HT is a feedback inhibitor of lactation in the bovine...
  7. ncbi Review article: serotonin receptors and transporters -- roles in normal and abnormal gastrointestinal motility
    M D Gershon
    Department of Anatomy and Cell Biology, Columbia University, New York, NY 10032, USA
    Aliment Pharmacol Ther 20:3-14. 2004
    ..The observation that molecular defects occur in the human gut in irritable bowel syndrome strengthens the hand of those seeking to legitimize the disease. At least it is not 'all in your head'. The bowel contributes...
  8. pmc Spinal 5-HT(2) and 5-HT(3) receptors mediate low, but not high, frequency TENS-induced antihyperalgesia in rats
    Rajan Radhakrishnan
    Graduate Program in Physical Therapy and Rehabilitation Science, College of Medicine 1 252 Medical Education Building, University of Iowa, Iowa City, IA 52242 1190, USA
    Pain 105:205-13. 2003
    ..Furthermore, spinal noradrenergic receptors are not involved in either low or high frequency TENS antihyperalgesia...
  9. ncbi Serotonin signaling is a very early step in patterning of the left-right axis in chick and frog embryos
    Takahiro Fukumoto
    Cytokine Biology Department, The Forsyth Institute and Department of Oral and Developmental Biology, Harvard Medical School, 140 The Fenway, Boston, Massachusetts 02115, USA
    Curr Biol 15:794-803. 2005
    ..Serotonin (5-HT) is a key neurotransmitter with crucial roles in physiology and cognition. We tested the hypothesis that LR patterning required prenervous serotonin signaling and characterized the 5-HT pathway in chick and frog embryos...
  10. ncbi Importance of phenylalanine 107 in agonist recognition by the 5-hydroxytryptamine(3A) receptor
    L J Steward
    Yoshitomi Research Institute of Neuroscience in Glasgow, University of Glasgow, United Kingdom
    Mol Pharmacol 57:1249-55. 2000
    ..These data suggest that F107 is an important determinant of agonist recognition at the 5-HT(3) receptor...
  11. ncbi An excitatory role for 5-HT in spinal inflammatory nociceptive transmission; state-dependent actions via dorsal horn 5-HT(3) receptors in the anaesthetized rat
    G M Green
    Department of Pharmacology, University College London, Gower Street, WC1E 6BT, London, UK
    Pain 89:81-88. 2000
    ..However, during formalin (but not carrageenan) induced inflammation this system is activated, maintaining the response of nociceptive spinal neurones to peripheral formalin...
  12. ncbi Expression of serotonin receptors in bone
    I Westbroek
    Leiden University Medical Center, Department of Molecular Cell Biology, Wassenaarseweg 72, 2333 AL, Leiden, The Netherlands
    J Biol Chem 276:28961-8. 2001
    The 5-hydroxytryptamine (5-HT) receptors 5-HT(2A), 5-HT(2B), and 5-HT(2C) belong to a subfamily of serotonin receptors. Amino acid and mRNA sequences of these receptors have been published for several species including man...
  13. doi Pharmacogenetics of parkinsonism, rigidity, rest tremor, and bradykinesia in African-Caribbean inpatients: differences in association with dopamine and serotonin receptors
    Asmar F Al Hadithy
    Department of Pharmacotherapy and Pharmaceutical Care, GUIDE, University of Groningen, Groningen, The Netherlands
    Am J Med Genet B Neuropsychiatr Genet 147:890-7. 2008
    ..41). Since AIPs subsymptoms (rigidity, bradykinesia, and rest-tremor) may differ pharmacogenetically, our data strongly support symptom-specific analysis of AIP. However, further research is warranted to confirm our findings...
  14. ncbi Differences in the central nervous system distribution and pharmacology of the mouse 5-hydroxytryptamine-6 receptor compared with rat and human receptors investigated by radioligand binding, site-directed mutagenesis, and molecular modeling
    Warren D Hirst
    Neurology and GI Centre of Excellence for Drug Discovery, GlaxoSmithKline, New Frontiers Science Park, Third Avenue, Harlow, Essex, CM19 5AW, United Kingdom
    Mol Pharmacol 64:1295-308. 2003
    ....
  15. doi Signaling at G-protein-coupled serotonin receptors: recent advances and future research directions
    Mark J Millan
    Institut de Recherche Servier, 125 Chemin de Ronde, 78290 Croissy sur Seine, Paris, France
    Trends Pharmacol Sci 29:454-64. 2008
    ..In view of the diversity of transduction mechanisms engaged by 5-HT, much of this discussion is relevant to other classes of G-protein-coupled receptors...
  16. ncbi Roles of 5-hydroxytryptamine (5-HT) receptor subtypes in the inhibitory effects of 5-HT on C-fiber responses of spinal wide dynamic range neurons in rats
    Feng Yu Liu
    Neuroscience Research Institute and Department of Neurobiology, Peking University, Key Laboratory for Neuroscience, Ministry of Education, Beijing, People s Republic of China
    J Pharmacol Exp Ther 321:1046-53. 2007
    ....
  17. ncbi Reduction in the density and expression, but not G-protein coupling, of serotonin receptors (5-HT1A) in 5-HT transporter knock-out mice: gender and brain region differences
    Q Li
    Laboratory of Clinical Science, National Institute of Mental Health, National Institutes of Health Clinical Center, Bethesda, Maryland 20892 1264, USA
    J Neurosci 20:7888-95. 2000
    ..Finally, alterations in G-protein coupling to 5-HT(1A) receptors are unlikely to be involved in the desensitization of 5-HT(1A) receptors in 5-HTT -/- mice...
  18. pmc Biphasic regulation of mammary epithelial resistance by serotonin through activation of multiple pathways
    Vaibhav P Pai
    Department of Molecular and Cellular Physiology, University of Cincinnati, Cincinnati, Ohio 45267 0576, USA
    J Biol Chem 283:30901-10. 2008
    ..These studies imply an integrated set of mechanisms whereby transient, modest activation of 5-HT7 promotes tight junction integrity, and sustained 5-HT7 activation drives involution by disrupting tight junctions...
  19. ncbi Serotonin 5-HT2a and 5-HT2c receptors stimulate amyloid precursor protein ectodomain secretion
    R M Nitsch
    Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Biol Chem 271:4188-94. 1996
    ..To determine whether other receptor classes can regulate APP processing, we examined the relation between serotonin receptors and APPs secretion...
  20. doi Regulation of protein kinase C Apl II by serotonin receptors in Aplysia
    Ikue Nagakura
    Department of Psychology, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada
    J Neurochem 115:994-1006. 2010
    ..Expression of 5HT(1Apl(a)) in SNs or genistein, an inhibitor of tyrosine kinases inhibited both PKC translocation and reversal of depression. These results suggest a non-canonical mechanism for the translocation of PKC Apl II in SNs...
  21. doi Identification, molecular structure and expression of two cloned serotonin receptors from the pond snail, Helisoma trivolvis
    Sabeen Mapara
    Department of Biological Sciences, University of Alberta, Edmonton, Alberta, Canada, T6G 2E9
    J Exp Biol 211:900-10. 2008
    ..trivolvis genomic cDNA, resulting in the cloning of two putative serotonin receptors. The deduced gene products both appear to be G protein-coupled serotonin receptors, with well-conserved ..
  22. ncbi Differential involvement of 5-HT(1B/1D) and 5-HT6 receptors in cognitive and non-cognitive symptoms in Alzheimer's disease
    M Garcia-Alloza
    Department of Pharmacology, School of Medicine, University of Navarra, Pamplona, Spain
    Neuropsychopharmacology 29:410-6. 2004
    ..The 5-HT(6)/ChAT ratio was related to aggression both in the frontal and temporal cortex. Therefore, antagonists acting at 5-HT(6) receptors could be useful in the treatment of non-cognitive symptoms associated to AD...
  23. ncbi Serotonin model of schizophrenia: emerging role of glutamate mechanisms
    G K Aghajanian
    Departments of Psychiatry, Yale University School of Medicine and the Connecticut Mental Health Center, 34 Park St, New Haven, CT, USA
    Brain Res Brain Res Rev 31:302-12. 2000
    ....
  24. ncbi The 5-HT1A antagonist, WAY 100 635, alleviates cognitive impairments induced by dizocilpine (MK-801) in monkeys
    J A Harder
    The School of Pharmacy, University of Bradford, W Yorks, UK
    Neuropharmacology 39:547-52. 2000
    ....
  25. ncbi Serotonin receptors involved in vasopressin and oxytocin secretion
    H Jørgensen
    Department of Medical Physiology, The Panum Institute, University of Copenhagen, Copenhagen, Denmark
    J Neuroendocrinol 15:242-9. 2003
    ..5-HT-induced oxytocin secretion involves 5-HT(1A), 5-HT(2C) and 5-HT(4) receptors; in addition an involvement of 5-HT(1B), 5-HT(5A) and 5-HT(7) receptors seems likely, whereas 5-HT(2A) and 5-HT(3) receptors seem to be less important...
  26. pmc Serotonin (5HT), fluoxetine, imipramine and dopamine target distinct 5HT receptor signaling to modulate Caenorhabditis elegans egg-laying behavior
    Catherine M Dempsey
    Department of Anatomy and Neurobiology, College of Medicine, University of California, Irvine, 92697 4040, USA
    Genetics 169:1425-36. 2005
    ..These results suggest that the actions of these drugs at specific receptor subtypes could determine their therapeutic efficacy. SSRIs and tricyclic antidepressants may regulate 5HT outputs independently of synaptic levels of 5HT...
  27. ncbi Abnormal neurochemical asymmetry in the temporal lobe of schizophrenia
    O Shirakawa
    Department of Psychiatry and Neurology, Kobe University School of Medicine, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 25:867-77. 2001
    ....
  28. ncbi Expression of serotonin receptors in allergic contact eczematous human skin
    Lena Lundeberg
    Department of Dermatology and Venereology, Karolinska Hospital, S 171 76 Stockholm, Sweden
    Arch Dermatol Res 294:393-8. 2002
    ..5-HT3R expression was found in the basal epidermal layer of eczematous and control skin. These findings indicate a plasticity in the effects of serotonin, especially regarding 5-HT1AR, in allergic contact eczematous skin...
  29. doi Subchronic effects of phencyclidine on dopamine and serotonin receptors: implications for schizophrenia
    Yong Kee Choi
    Mailman Research Center, McLean Division of Massachusetts General Hospital, Belmont, MA, USA
    J Mol Neurosci 38:227-35. 2009
    ..Subchronic PCP treatment did not alter levels of D(2), D(4), and 5HT(2A) receptors in all brain regions examined, which suggests a minimal role for these receptors in mediating subchronic actions of PCP in adult rats...
  30. doi Serotonin- and two putative serotonin receptors-like immunohistochemical reactivities in the ground crickets Dianemobius nigrofasciatus and Allonemobius allardi
    Qi Miao Shao
    Graduate School of Agriculture Science, Kobe University, Kobe, Japan
    J Insect Physiol 56:1576-86. 2010
    Serotonin (5-hydroxytryptamine; 5-HT)- and two putative serotonin receptors, 5-HT1A- and 5-HT1B-like, immunohistochemical reactivities were investigated in the cephalic ganglia of two ground crickets, Dianemobius nigrofasciatus and ..
  31. ncbi The dynamin-dependent, arrestin-independent internalization of 5-hydroxytryptamine 2A (5-HT2A) serotonin receptors reveals differential sorting of arrestins and 5-HT2A receptors during endocytosis
    A Bhatnagar
    Department of Biochemistry, Case Western Reserve University Medical School, Cleveland, Ohio 44106, USA
    J Biol Chem 276:8269-77. 2001
    ....
  32. ncbi Influence of the 5-HT6 receptor on acetylcholine release in the cortex: pharmacological characterization of 4-(2-bromo-6-pyrrolidin-1-ylpyridine-4-sulfonyl)phenylamine, a potent and selective 5-HT6 receptor antagonist
    Claus Riemer
    F Hoffmann LaRoche, Pharma Division, Preclinical Research, CH 4070 Basel, Switzerland
    J Med Chem 46:1273-6. 2003
    ....
  33. ncbi Association of the HTR6 polymorphism C267T with late-onset Alzheimer's disease in Chinese
    Rui Kan
    Center for Human and Animal Genetics, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China
    Neurosci Lett 372:27-9. 2004
    ..These data suggest that the HTR6 polymorphism C267T possibly involved in the susceptibility to LOAD as an APOE epsilon4-allele independent risk factor of LOAD...
  34. ncbi Immunohistochemical localization of serotonin receptors in the rat suprachiasmatic nucleus
    R W Moyer
    Department of Obstetrics and Gynaecology, Medical School University of Adelaide, South Australia, Australia
    Neurosci Lett 271:147-50. 1999
    ....
  35. ncbi A 5-HT(1B) receptor agonist inhibits light-induced suppression of pineal melatonin production
    M A Rea
    Brain Research Institute, Air Force Research Laboratory, Brooks AFB, TX, USA
    Brain Res 858:424-8. 2000
    ..The results are consistent with the interpretation that activation of presynaptic 5-HT(1B) receptors on retinal terminals in the SCN attenuates the effect of light on pineal melatonin production, as well as on circadian phase...
  36. ncbi 5-HT2A and 5-HT2C serotonin receptors differentially modulate mouse sexual arousal and the hypothalamo-pituitary-testicular response to the presence of a female
    Nina K Popova
    Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia
    Neuroendocrinology 76:28-34. 2002
    ..05). The present findings suggest that 5-HT2A/5-HT2C receptors may be involved in the neural control of male sexual motivation and arousal, presumably by exerting reciprocal facilitative (5-HT2A) or suppressive (5-HT2C) influences...
  37. ncbi Discriminative stimulus effects of m-chlorophenylpiperazine as a model of the role of serotonin receptors in anxiety
    Michael B Gatch
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, 3500 Camp Bowie Blvd, Fort Worth, TX 76107 2699, USA
    Life Sci 73:1347-67. 2003
    ..1-(3-Chlorophenyl)-piperazine (mCPP), which binds non-selectively to a wide range of serotonin receptors, has often been used to produce anxiety in humans and in animal models...
  38. ncbi Functional characterisation of the Drosophila 5-HTdro1 and 5-HTdro2B serotonin receptors in insect cells: activation of a G(alpha) s-like protein by 5-HTdro1 but lack of coupling to inhibitory G-proteins by 5-HTdro2B
    L A Obosi
    School of Biological and Molecular Sciences, Oxford Brookes University, UK
    FEBS Lett 381:233-6. 1996
    ..Immunoblot analysis of the endogenous G-proteins revealed that Sf9 cells lack the G-protein subtypes G(alpha i 1-3) and G(alpha)o, but express the subtype G(alpha)s and G(alpha)q...
  39. ncbi Fenfluramine-induced pulmonary vasoconstriction: role of serotonin receptors and potassium channels
    S Belohlavkova
    Department of Pathophysiology, Charles University First Medical School, Prague 128 53, Czech Republic
    J Appl Physiol 91:755-61. 2001
    ..This finding suggests that preexisting K(V)-channel insufficiency may predispose some patients to the development of pulmonary hypertension during fenfluramine treatment...
  40. ncbi Structural and functional conservation of serotonin receptors throughout evolution
    R Hen
    Laboratoire de Genetique Moleculaire des Eucaryotes du CNRS, Unité 184 de Biologie Moléculaire et de Génie Génétique, INSERM, Institut de Chimie Biologique, Faculte de Medecine, Strasbourg, France
    EXS 63:266-78. 1993
    Pharmacological studies as well as molecular cloning of serotonin receptors have revealed a multiplicity of receptor subtypes not only in mammals but also in molluscs and arthropods...
  41. ncbi GABA, serotonin and serotonin receptors in the rat inferior colliculus
    Daniel Peruzzi
    New York College of Osteopathic Medicine, New York Institute of Technology, Room 027, NYCOM II, Northern Boulevard, Old Westbury, NY 11568, USA
    Brain Res 998:247-50. 2004
    ..Immunohistochemical techniques were used to study the relationship between GABA and serotonin receptors in the central nucleus of the rat inferior colliculus...
  42. doi Characterization of serotonin receptors in pregnant human myometrium
    Yolande Cordeaux
    University of Cambridge, Department of Obstetrics and Gynaecology, Level 2, The Rosie Hospital Addenbrooke s Box 223, Robinson Way, Cambridge CB22SW, UK
    J Pharmacol Exp Ther 328:682-91. 2009
    ..This study provides strong evidence for the expression of contractile 5-HT(2A) receptors in pregnant human myometrium, and this receptor is a potential target for novel uterotonic therapies...
  43. ncbi Serotonin receptors 5-HT1A and 5-HT3 reduce hyperexcitability of dorsal horn neurons after chronic spinal cord hemisection injury in rat
    Bryan C Hains
    Department of Anatomy and Neurosciences, and Marine Biomedical Institute, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555 043, USA
    Exp Brain Res 149:174-86. 2003
    ....
  44. pmc T102C polymorphism in the 5HT2A gene and schizophrenia: relation to phenotype and drug response variability
    R Joober
    Montreal General Hospital Research Institute, Douglas Hospital Research Centre, Verdun QC
    J Psychiatry Neurosci 24:141-6. 1999
    ..These result suggest that the 5HT2A-receptor gene may play a role in a subset of schizophrenia characterized by poor long-term outcome and poor response to neuroleptics...
  45. ncbi Interactions between effectors linked to serotonin receptors
    K A Berg
    Department of Pharmacology, University of Texas Health Science Center, San Antonio 78284 7764, USA
    Ann N Y Acad Sci 861:111-20. 1998
    ..Perhaps by exploiting these interactions, new targets for pharmacotherapy may be uncovered which will provide for increased efficacy and specificity of drug action...
  46. ncbi Ras-dependent ERK activation by the human G(s)-coupled serotonin receptors 5-HT4(b) and 5-HT7(a)
    Jens Henrik Norum
    Merck Sharp and Dohme Cardiovascular Research Center, Institute for Surgical Research and Department of Pharmacology, Rikshospitalet University Hospital, University of Oslo, N 0316 Oslo, Norway
    J Biol Chem 278:3098-104. 2003
    ..The human G protein-coupled serotonin receptors 5-HT(4(b)) and 5-HT(7(a)) couple to G(s) and elevate intracellular cAMP...
  47. ncbi Comparative localization of two serotonin receptors and sensorin in the central nervous system of Aplysia californica
    Demian Barbas
    Departement de Biochimie, Universite de Montreal, CP 6128, Succursale Centre Ville, Montreal, Quebec H3C 3J7, Canada
    J Comp Neurol 490:295-304. 2005
    ..Little is known about the nature and contribution of serotonin receptors involved in the numerous serotonin-mediated physiological responses in Aplysia...
  48. ncbi The roles of different types of serotonin receptors in activation of the hypophyseal-testicular complex induced in mice by the presence of a female
    T G Amstislavskaya
    Institute of Cytology and Genetics, Siberian Division, Russian Academy of Sciences, Novosibirsk
    Neurosci Behav Physiol 34:833-7. 2004
    ..Blockade of HHTC activation induced by the presence of females appears to involve 5-HT1A and 5-HT2C receptors, while activation involves 5-HT2A and 5-HT3 receptors...
  49. ncbi 5-HT6 receptor binding sites in schizophrenia and following antipsychotic drug administration: autoradiographic studies with [125I]SB-258585
    Simon Z East
    University of Oxford, Department of Psychiatry, Warneford Hospital, Oxford OX3 7JX, UK
    Synapse 45:191-9. 2002
    ....
  50. ncbi 5-Hydroxytryptamine receptors
    E Zifa
    Unité de Pharmacologie Neuro Immuno Endocrinienne Institut Pasteur, Paris, France
    Pharmacol Rev 44:401-58. 1992
  51. pmc The 5HT2 receptor defines a family of structurally distinct but functionally conserved serotonin receptors
    D Julius
    Department of Biochemistry and Molecular Biophysics, College of Physicians and Surgeons, Columbia University, New York, NY 10032
    Proc Natl Acad Sci U S A 87:928-32. 1990
    ..However, RNA blotting shows that these two receptor subtypes are differentially expressed in the central nervous system. In this manner, structurally and functionally homologous receptor subtypes may elicit distinct physiologic actions...
  52. ncbi Association of the serotonin transporter and receptor gene polymorphisms in neuropsychiatric symptoms in Alzheimer disease
    Frederic Assal
    Department of Neurology, The David Geffen School of Medicine at UCLA, Los Angeles, Calif, USA
    Arch Neurol 61:1249-53. 2004
    ..Neuropsychiatric symptoms have been associated with polymorphisms of the promoter region (5-HTTPR ) and intron 2 of the serotonin transporter gene (5-HTTVNTR) or the 5-HT2A and 5-HT2C receptor genes in some but not all studies...
  53. ncbi Drugs acting on serotonin receptors for the treatment of functional GI disorders
    Marcello Tonini
    Department of Physiological and Pharmacological Sciences, University of Pavia, Pavia, Italy
    Dig Dis 24:59-69. 2006
    ....
  54. ncbi Involvement of spinal serotonin receptors in the regulation of intraspinal acetylcholine release
    Mahinda Kommalage
    Department of Neuroscience, Division of Comparative Medicine, BMC, Uppsala University, Box 572, S 75123, Uppsala, Sweden
    Eur J Pharmacol 509:127-34. 2005
    ..The results suggest that 5-HT1A and the 5-HT2A receptors are involved in the regulation of acetylcholine release in the spinal cord...
  55. pmc Effect of loxapine on peripheral dopamine-like and serotonin receptors in patients with schizophrenia
    Amarendra N Singh
    Department of Psychiatry, Queen s University, Kingston, Ont
    J Psychiatry Neurosci 28:39-47. 2003
    ..To investigate the effect of loxapine on peripheral dopamine D2-like and serotonin receptor binding and on psychotic symptoms...
  56. ncbi gamma-Carbolines: binding at 5-HT5A serotonin receptors
    Nantaka Khorana
    Department of Medicinal Chemistry, School of Pharmacy, Virginia Commonwealth University, Richmond, VA 23298, USA
    Bioorg Med Chem 11:717-22. 2003
    ..Although 17 also binds at 5-HT(2) receptors, it serves as a novel lead for the further development of 5-HT(5A) ligands...
  57. ncbi Stable expression of constitutively activated mutant h5HT6 and h5HT7 serotonin receptors: inverse agonist activity of antipsychotic drugs
    Anil Purohit
    Center for Neuropharmacology and Neuroscience, Albany Medical College, 47 New Scotland Avenue, Albany, NY 12208, USA
    Psychopharmacology (Berl) 179:461-9. 2005
    ..Typical and atypical antipsychotic drugs were assayed for their potencies as inverse agonists at these mutated receptors...
  58. ncbi Increased mRNA expression of alpha2A-adrenoceptors, serotonin receptors and mu-opioid receptors in the brains of suicide victims
    Pablo V Escriba
    Laboratory of Neuropharmacology, Associated Unit of the Cajal Institute CSIC, Department of Biology, Institut Universitari d Investigacio en Ciencies de la Salut IUNICS, University of the Balearic Islands, Palma de Mallorca, Spain pablo escriba uib es
    Neuropsychopharmacology 29:1512-21. 2004
    ..Alterations in adrenoceptors, serotonin receptors, and other G protein-coupled receptors (GPCRs) have been associated with suicide and depression...
  59. pmc Open probability of homomeric murine 5-HT3A serotonin receptors depends on subunit occupancy
    D D Mott
    Department of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322-3090, USA
    J Physiol 535:427-43. 2001
    ..Increasing the desensitization rate constants in this model can generate desensitization that is more rapid than deactivation, as observed in a subpopulation of our patches...
  60. ncbi Adolescent nicotine administration alters serotonin receptors and cell signaling mediated through adenylyl cyclase
    Z Xu
    Department of Pharmacology and Cancer Biology, Box 3813 DUMC, Duke University Medical Center, Durham, NC 27710, USA
    Brain Res 951:280-92. 2002
    ....
  61. doi Binding of serotonin and N1-benzenesulfonyltryptamine-related analogs at human 5-HT6 serotonin receptors: receptor modeling studies
    Małgorzata Dukat
    Department of Medicinal Chemistry, School of Pharmacy, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, VA 23298 0540, USA
    J Med Chem 51:603-11. 2008
    ..The results indicate that the presence or absence of an N1-benzenesulfonyl group is a major determinant of the manner in which tryptamine-related agents bind at 5-HT6 serotonin receptors.
  62. ncbi Serotonin receptors modulate GABA(A) receptor channels through activation of anchored protein kinase C in prefrontal cortical neurons
    J Feng
    Department of Physiology and Biophysics, State University of New York at Buffalo, Buffalo, New York 14214, USA
    J Neurosci 21:6502-11. 2001
    ..The suppression of GABAergic signaling provides a novel mechanism for serotonergic modulation of PFC neuronal activity, which may underlie the actions of many antidepressant drugs...
  63. pmc Mammary gland homeostasis employs serotonergic regulation of epithelial tight junctions
    Malinda A Stull
    Department of Molecular and Cellular Physiology, University of Cincinnati, Cincinnati, OH 45267 0576, USA
    Proc Natl Acad Sci U S A 104:16708-13. 2007
    ..One mechanism responsible for this process is serotonin-mediated opening of tight junctions, which dissipates the transepithelial gradients necessary for milk secretion...
  64. ncbi The physiological role of 5-HT2A receptors in working memory
    Graham V Williams
    Section of Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Neurosci 22:2843-54. 2002
    ..We conclude that prefrontal 5-HT2A receptors have a hitherto unrecognized role in the cognitive function of working memory, which involves actions at both excitatory and inhibitory elements within local circuitry...
  65. ncbi Serotonin receptors: their key role in drugs to treat schizophrenia
    Herbert Y Meltzer
    Department of Psychiatry, Division of Psychopharmacology, Vanderbilt University School of Medicine, Suite 306, 1601 23rd Avenue, Nashville, TN 37212, USA
    Prog Neuropsychopharmacol Biol Psychiatry 27:1159-72. 2003
    ..g., the D3 or D4 receptor, and drugs that are selective for them...
  66. ncbi Role of serotonin in the hepato-gastroIntestinal tract: an old molecule for new perspectives
    M Lesurtel
    Swiss HPB Center, Department of Visceral and Transplant Surgery, University Hospital of Zurich, Ramistrasse 100, Zurich, Switzerland
    Cell Mol Life Sci 65:940-52. 2008
    ..Better understanding of the role of the serotonin receptor subtypes and serotonin mechanisms of action in the liver and gut may open new therapeutic strategies in hepato-gastrointestinal diseases...
  67. ncbi Structural features of the ligand-binding domain of the serotonin 5HT3 receptor
    D Yan
    Departments of Pharmacology and Physiology, MCP Hahnemann University, Philadelphia, Pennsylvania 19129, USA
    J Biol Chem 274:5537-41. 1999
    ....
  68. ncbi Coexpression of the cannabinoid receptor type 1 with dopamine and serotonin receptors in distinct neuronal subpopulations of the adult mouse forebrain
    H Hermann
    Group Molecular Genetics of Behavior, Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, D 80804, Munich, Germany
    Neuroscience 109:451-60. 2002
    ..Together with overlapping expression patterns of dopamine and serotonin receptors this suggests a potential of CB1 to modulate the function of the dopamine and serotonin system...
  69. ncbi Distribution of serotonin 2A, 2C and 3 receptor mRNA in spinal cord and medulla oblongata
    M I Fonseca
    Laboratory of Cellular and Molecular Neurobiology, Department of Neurobiology and Behaviour, University of California, Irvine, CA 92697-4550, USA
    Brain Res Mol Brain Res 89:11-9. 2001
    ..The results show a distinct distribution of the three subtypes of receptors supporting their physiological roles and will help to understand the mechanisms of nociception and motor function...
  70. ncbi Serotonin-induced increases in adult cell proliferation and neurogenesis are mediated through different and common 5-HT receptor subtypes in the dentate gyrus and the subventricular zone
    Mounira Banasr
    Cellular and Functional Neurobiology Unit, CNRS, Marseille, France
    Neuropsychopharmacology 29:450-60. 2004
    ....
  71. doi Serotonin receptors
    David E Nichols
    Department of Medicinal Chemistry and Molecular Pharmacology, School of Pharmacy and Pharmaceutical Sciences, Purdue University, West Lafayette, Indiana 47906 2091, USA
    Chem Rev 108:1614-41. 2008
  72. ncbi Cellular and subcellular distribution of the serotonin 5-HT2A receptor in the central nervous system of adult rat
    V Cornea-Hébert
    Départements de pathologie et biologie cellulaire et de physiologie, and Centre de Recherche en Sciences Neurologiques, Faculte de Medecine, Universite de Montreal, Quebec, Canada
    J Comp Neurol 409:187-209. 1999
    ....
  73. pmc A family of Drosophila serotonin receptors with distinct intracellular signalling properties and expression patterns
    F Saudou
    Laboratoire de Genetique Moleculaire des Eucaryotes du CNRS, Unité 184 de Génie Génétique et de Biologie Moléculaire de l INSERM, Institut de Chimie Biologique, Faculte de Medecine, Strasbourg, France
    EMBO J 11:7-17. 1992
    ..We have isolated cDNA clones encoding three distinct Drosophila serotonin receptors which belong to the G protein-coupled receptor family...
  74. ncbi Primary structure and functional expression of the 5HT3 receptor, a serotonin-gated ion channel
    A V Maricq
    Department of Pharmacology, University of California, San Francisco 94143 0450
    Science 254:432-7. 1991
    ..Messenger RNA encoding this receptor is found in the brain, spinal cord, and heart. This receptor defines a new class of excitatory ligand-gated channels...
  75. pmc Antipsychotic drugs disrupt normal development in Caenorhabditis elegans via additional mechanisms besides dopamine and serotonin receptors
    Dallas R Donohoe
    Department of Pharmacology, Toxicology and Neuroscience, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, LA 71130, USA
    Pharmacol Res 54:361-72. 2006
    ..These findings suggest that antipsychotic drugs may interfere with normal developmental processes and provide a tool for investigating the key signaling pathways involved...
  76. pmc Serotonin receptors are involved in the spinal mediation of descending facilitation of surgical incision-induced increase of Fos-like immunoreactivity in rats
    João Walter S Silveira
    Department of Pharmacology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, SP 14049 900, Brazil
    Mol Pain 6:17. 2010
    ..The number of spinal c-Fos positive neurons of rats treated intrathecally with serotonin, noradrenaline or acetylcholine antagonists where evaluated to study the descending pathways activated by a surgical paw incision...
  77. ncbi Expression of genes coding melatonin and serotonin receptors in rodent skin
    Andrzej Slominski
    Department of Pathology, University of Tennessee Health Science Center, 930 Madison Ave, Room 519, Memphis, TN 38163, USA
    Biochim Biophys Acta 1680:67-70. 2004
    Targeted search for expression of melatonin and serotonin receptors genes in the skin of C57BL/6J mice showed expression of MT1B (but not MT1A). Mouse skin and hamster melanomas also expressed 5HT2B and 5HT7...
  78. ncbi Involvement of serotonin in depression: evidence from postmortem and imaging studies of serotonin receptors and the serotonin transporter
    Craig A Stockmeier
    Department of Psychiatry and Human Behavior Box 127, The University of Mississippi Medical Center, Jackson 39211, USA
    J Psychiatr Res 37:357-73. 2003
    Definitive conclusions on the role of serotonin receptors and transporter in suicide and depression have been elusive in studies of postmortem brain tissue...
  79. ncbi Association study of 90 candidate gene polymorphisms in panic disorder
    Eduard Maron
    Department of Psychiatry, University of Tartu, Tartu 50417, Estonia
    Psychiatr Genet 15:17-24. 2005
    ..In the present investigation we screened a large number of single nucleotide polymorphisms in the genes relevant to the neurobiology of anxiety for their association with panic disorder (PD)...
  80. ncbi A systematic review of association studies investigating genes coding for serotonin receptors and the serotonin transporter: II. Suicidal behavior
    M Anguelova
    Dougals Hospital Research Center, McGill University, Montreal, Canada
    Mol Psychiatry 8:646-53. 2003
    ..09 CI : 0.93-1.27, P=0.319). The 5-HTT result was robust and remained significant following sensitivity analysis, suggesting that 5-HTT may play a role in the predisposition to suicide...
  81. ncbi Elevated alcohol consumption in null mutant mice lacking 5-HT1B serotonin receptors
    J C Crabbe
    Department of Veterans, Affairs Medical Center, Portland, Oregon, USA
    Nat Genet 14:98-101. 1996
    ....
  82. ncbi A direct interaction of PSD-95 with 5-HT2A serotonin receptors regulates receptor trafficking and signal transduction
    Zongqi Xia
    Department of Biochemistry, Case Western Reserve University School of Medicine, 10900 Euclid Avenue, Cleveland, OH 44106, USA
    J Biol Chem 278:21901-8. 2003
    ..Taken together, the present work elucidates novel roles for PSD-95 in regulating the functional activity and intracellular trafficking of 5-HT2A receptors and possibly other GPCRs...
  83. ncbi Molecular biology of serotonin receptors structure and function at the molecular level
    Wesley K Kroeze
    Department of Biochemistry, Case Western Reserve University, Cleveland, OH 44106, USA
    Curr Top Med Chem 2:507-28. 2002
    ..Finally, examples will be given to demonstrate that a detailed knowledge of the predicted structure of one receptor can be useful for structure-based drug design...
  84. ncbi Eating disorder and epilepsy in mice lacking 5-HT2c serotonin receptors
    L H Tecott
    Department of Pharmacology, University of California, San Francisco 94143 0450, USA
    Nature 374:542-6. 1995
    ..Mutant animals are also prone to spontaneous death from seizures, suggesting that 5-HT2C receptors mediate tonic inhibition of neuronal network excitability...
  85. ncbi The pharmacological and functional characteristics of the serotonin 5-HT(3A) receptor are specifically modified by a 5-HT(3B) receptor subunit
    A E Dubin
    R W Johnson Pharmaceutical Research Institute, San Diego, California 92121, USA
    J Biol Chem 274:30799-810. 1999
    ..Furthermore, 5-HT(3A) and 5-HT(3B) mRNAs were expressed in spleen and intestine. Our data suggest that 5-HT(3B) might contribute to tissue-specific functional changes in 5-HT(3)-mediated signaling and/or modulation...
  86. ncbi Molecular, pharmacological and functional diversity of 5-HT receptors
    Daniel Hoyer
    Nervous System Research, WSJ 386 745, Novartis Pharma AG, CH 4002, Basel, Switzerland daniel1 hoyer pharma novartis com
    Pharmacol Biochem Behav 71:533-54. 2002
    ..The reward for unravelling this complex array of serotonin receptor--effector systems may be substantial, the ultimate prize being the development of important new drugs in a range of disease areas...
  87. ncbi SER-7b, a constitutively active Galphas coupled 5-HT7-like receptor expressed in the Caenorhabditis elegans M4 pharyngeal motorneuron
    Robert J Hobson
    Department of Biological Sciences, University of Toledo, Ohio, USA
    J Neurochem 87:22-9. 2003
    ..This is the first report of a Galphas coupled biogenic amine receptor in nematodes and the localization of SER-7b in the M4 pharyngeal motorneuron suggests that SER-7b may play a role in the regulation of pharyngeal pumping...
  88. doi Serotonin receptors, novel targets of sulforaphane identified by proteomic analysis in Caco-2 cells
    Lina Mastrangelo
    School of Medicine, Health Policy and Practice, University of East Anglia, Norwich Research Park, Norwich, United Kingdom
    Cancer Res 68:5487-91. 2008
    ..Thus, the effect of sulforaphane may help to elucidate signaling pathways serotonin-mediated in colon cancer and lead to development of potential novel therapeutic agents...
  89. ncbi Association analysis of HTR6 and HTR2A polymorphisms in sporadic Alzheimer's disease
    J Thome
    Laboratory of Biochemistry, Central Institute of Mental Health, Mannheim, Federal Republic of Germany
    J Neural Transm 108:1175-80. 2001
    ..These polymorphisms probably do not represent major genetic risk factors of AD. However, further studies including other genetic variants of the serotonergic neurotransmitter system are needed in order to elucidate their role in AD...
  90. pmc 5-Hydroxytryptamine2A serotonin receptors in the primate cerebral cortex: possible site of action of hallucinogenic and antipsychotic drugs in pyramidal cell apical dendrites
    R L Jakab
    Section of Neurobiology, Yale University School of Medicine, New Haven, CT 06511, USA
    Proc Natl Acad Sci U S A 95:735-40. 1998
    To identify the cortical sites where 5-hydroxytryptamine2A (5-HT2A) serotonin receptors respond to the action of hallucinogens and atypical antipsychotic drugs, we have examined the cellular and subcellular distribution of these ..
  91. ncbi Higher expression of serotonin 5-HT(2A) receptors in the postmortem brains of teenage suicide victims
    Ghanshyam N Pandey
    Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, 60612, USA
    Am J Psychiatry 159:419-29. 2002
    ..The authors examined whether 5-HT(2A) receptor subtypes are altered in the postmortem brains of teenage suicide victims...
  92. pmc PSD-95 is essential for hallucinogen and atypical antipsychotic drug actions at serotonin receptors
    Atheir I Abbas
    Department of Biochemistry, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
    J Neurosci 29:7124-36. 2009
    ..These results demonstrate that PSD-95, in addition to the well known role it plays in scaffolding macromolecular glutamatergic signaling complexes, profoundly modulates metabotropic 5-HT(2A) and 5-HT(2C) receptor function...
  93. pmc Inhibition of photocarcinogenesis by platelet-activating factor or serotonin receptor antagonists
    Coimbatore S Sreevidya
    Department of Immunology and the Center for Cancer Immunology Research, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Cancer Res 68:3978-84. 2008
    ....
  94. ncbi Evidence for a model of agonist-induced activation of 5-hydroxytryptamine 2A serotonin receptors that involves the disruption of a strong ionic interaction between helices 3 and 6
    David A Shapiro
    Department of Biochemistry, Case Western Reserve University Medical School, Cleveland, Ohio 44106 4935, USA
    J Biol Chem 277:11441-9. 2002
    ..L. Roth and D. A. Shapiro (2001) Expert Opin. Ther. Targets 5, 685-695) and others, that this may represent a general mechanism of activation for many, but not all, G-protein-coupled receptors...
  95. ncbi The role of 5-hydroxytryptamine1A and 5-hydroxytryptamine1B receptors in modulating spinal nociceptive transmission in normal and carrageenan-injected rats
    Y Zhang
    State Key Laboratory of Medical Neurobiology, Department of Neurobiology, Medical Center of Fudan University, 138 Yi Xue Yuan Road, 200032, Shanghai, China
    Pain 92:201-11. 2001
    ..The excitability of dorsal horn WDR neurons and the sensitivity of the neurons to intrathecal 5-HT1A and 5-HT1B receptor agonists might increase following carrageenan-induced inflammation...
  96. ncbi 5-HT1F receptor agonists in acute migraine treatment: a hypothesis
    N M Ramadan
    Eli Lilly and Co, Indiana, USA
    Cephalalgia 23:776-85. 2003
    ..v) LY334370 is effective in acute migraine, and does not cause any symptoms/signs of coronary vasoconstriction. Preclinical experiments and clinical observations argue for a role of selective 5-HT1F agonists in migraine...
  97. ncbi The effect of paroxetine on 5-HT(2A) receptors in depression: an [(18)F]setoperone PET imaging study
    J H Meyer
    Clarke Division, Centre for Addictions and Mental Health, Department ofPsychiatry, University of Toronto, Ontario, Canada
    Am J Psychiatry 158:78-85. 2001
    ..The objective of this study was to evaluate the effect of 6 weeks of paroxetine treatment on 5-HT(2A) receptors in depressed patients...
  98. ncbi A systematic review of association studies investigating genes coding for serotonin receptors and the serotonin transporter: I. Affective disorders
    M Anguelova
    Douglas Hospital Research Center, McGill University, Montreal, Canada
    Mol Psychiatry 8:574-91. 2003
    ..investigating the association between affective disorders (MDD and BD) and variation at genes coding for serotonin receptors and the serotonin transporter...
  99. ncbi Binding of isotryptamines and indenes at h5-HT6 serotonin receptors
    Renata Kolanos
    Department of Medicinal Chemistry, School of Pharmacy, Virginia Commonwealth University, Richmond, VA 23298 0540, USA
    Bioorg Med Chem Lett 15:1987-91. 2005
    To determine if the indolic nitrogen atom is required for the binding of N(1)-benzyltryptamines at h5-HT(6) serotonin receptors, several isotryptamines and indene analogs were examined...
  100. pmc Dual excitatory and inhibitory serotonergic inputs modulate egg laying in Caenorhabditis elegans
    Vera M Hapiak
    Department of Biological Sciences, University of Toledo, Toledo, Ohio 43606 3390, USA
    Genetics 181:153-63. 2009
    ..The 5-HT sensitivity of egg laying could be restored by ser-5 muscle expression. Together, these results highlight the dual excitatory/inhibitory serotonergic inputs that combine to modulate egg laying...
  101. doi Serotonin: a review
    L F Mohammad-Zadeh
    Southern Arizona Veterinary Specialty and Emergency Center, Tucson, AZ 85705, USA
    J Vet Pharmacol Ther 31:187-99. 2008
    ..This paper provides a review the physiology of serotonin and its involvement in the pathophysiologic mechanisms of various conditions, including the Serotonin Syndrome...

Research Grants67

  1. Interaction between RNA interference and RNA editing pathways
    Kazuko Nishikura; Fiscal Year: 2013
    ..genome can result, as demonstrated with transcripts of glutamate receptor (GluR) ion channels and 5-HT2C serotonin receptors. However, the most common targets for A I editing are non-coding RNAs that contain inverted repeats of ..
  2. Mechanisms of Bone Loss from Administration of the Second-Generation Antipsychoti
    KATHERINE JEAN MOTYL; Fiscal Year: 2013
    ..a major role for serotonin in regulation of bone remodeling, and bone cells express receptors (including serotonin receptors) that could be affected by SGAs...
  3. Hiv-1 Infection: Central Serotonergic Activity and its Health Implications
    Adarsh M Kumar; Fiscal Year: 2010
    ....
  4. BRAINSTEM MATURATION IN THE SUDDEN INFANT DEATH SYNDROME
    HANNAH CHASE KINNEY; Fiscal Year: 2013
    ..Our goal is to determine the fundamental basis of this deficiency by state-of-the-art techniques in human brainstem analysis. Such knowledge is essential to the future development of a means to identify and treat living infants at risk. ..
  5. Serotonin Receptor Modulation of Neurotrophic Factors in the Retina
    Mark E Pennesi; Fiscal Year: 2013
    ..The first specific aim will characterize the presence and distribution of serotonin receptors, serotonin transporters in the mouse and human retina and RPE...
  6. Development and Functional Analysis of Components of the Zebrafish Serotonin Sign
    Kenneth N Wallace; Fiscal Year: 2012
    ..Genetic defects identified in this research will contribute to understanding these conditions. ..
  7. Mapping serotonin receptors in lower urinary tract innervation
    E Michelle Southard-Smith; Fiscal Year: 2013
    ..Signaling through serotonin receptors (5-HTRs) has been shown to modulate nociception and contributes to sensitization of the sensory neurons...
  8. Maternal flu infection and brain development in primates
    Christopher L Coe; Fiscal Year: 2010
    ..b>Serotonin receptors and transporter proteins are also present in the placenta...
  9. MECHANISM OF CARDIORESPIRATORY RHYTHM IN NEONATES
    David Mendelowitz; Fiscal Year: 2013
    ....
  10. Pathogenesis of Sleep Disordered Breathing in Spinal Cord Injury Patients
    ABDUL SANKRI-TARBICHI; Fiscal Year: 2013
    ..Specific Aim (3): To determine the stimulatory effect of systemic serotonin receptors agonists on ventilatory motor activity in SCI patients during sleep...
  11. Neurobiological basis of Depression as a Comorbidity in Epilepsy
    Andrey M Mazarati; Fiscal Year: 2010
    ..the strength of raphe-hippocampal serotonergic innervation), and quantitative autoradiography of 5-HT1A serotonin receptors and serotonin transporter in the hippocampus...
  12. MODULATION OF MIGRAINE CIRCUIT BY SEROTONIN 1D RECEPTOR-ASSOCIATED PROTEINS
    Yuqing Cao; Fiscal Year: 2013
    ....
  13. Upper airway control during disrupted and misaligned sleep
    LESZEK K KUBIN; Fiscal Year: 2013
    ..As such, they will fill a major gap in our understanding of state-dependent control of the upper airway under conditions highly relevant to OSA. ..
  14. Serotonin 1B Receptor Imaging in Major Depressive Disorder
    Alexander Neumeister; Fiscal Year: 2010
    ..Serotonin is one of the brain's natural chemicals. Serotonin binds to serotonin receptors (binding sites) type 1B on brain cells to regulate emotion, anxiety, sleep, and stress hormones...
  15. Structural Biology of G-Protein Coupled Receptors
    Wayne A Hendrickson; Fiscal Year: 2011
    ..in eukaryotic ells, and processes controlled by these receptors are relevant in human disease;notably, serotonin receptors are involved in disorders of mood such as depression, FSHR and LHR are crucial for human reproduction, and ..
  16. TWO TYPES OF MONOAMINE OXIDASE
    Jean Chen Shih; Fiscal Year: 2013
    ..abstract_text> ..
  17. 5 -Hydroxytryptophan Regulation of Endothelial Cell Signals for Lung Inflammation
    Joan M Cook-Mills; Fiscal Year: 2013
    ..5HTP is metabolized to serotonin and then serotonin binds inhibitory or stimulatory serotonin receptors (HTRs) or serotonin is covalently linked to proteins (serotonylation)...
  18. Serotonin Reuptake Inhibitors and Bone Mineralization in Adolescents
    Chadi A Calarge; Fiscal Year: 2013
    ..experiments have shown that bone cells express the serotonin transporter and a variety of functional serotonin receptors whose activity modulates bone turnover...
  19. Contribution of caveolin to diabetic vascular dysfunction
    Kathryn G Lamping; Fiscal Year: 2013
    ..Rho-dependent contractions are similarly increased in diabetes. Our overall hypothesis is that serotonin receptors and their downstream signaling molecules are localized within caveolae in an inactive state...
  20. Role of Central 5-HT Transmission in Respiratory Arrest Induced by Seizures
    Huajun Feng; Fiscal Year: 2013
    ..Successful implementation of the proposed studies will not only shed important light on the mechanisms of SUDEP but also provide useful information on treatments for this devastating epileptic event. ..
  21. Optical probes for controlling cellular function
    GRAHAM ELLIS-DAVIES; Fiscal Year: 2013
    ..g. AMPA, dopamine, adenosine, serotonin, agonists/antagonists of dopamine and serotonin receptors, etc.)...
  22. G Protein Signaling in the C. elegans Nervous System
    Michael R Koelle; Fiscal Year: 2013
    ..Our goal is to understand how the many G protein coupled serotonin receptors function together to mediate appropriate responses to this neurotransmitter, and to find out what happens ..
  23. Functional characterization of SSRI resistant genes using C. elegans
    JI Y SZE; Fiscal Year: 2010
    ..The fourth aim is to examine the genetic interactions between new fluoxetine-resistant genes and serotonin receptors. By testing serotonin deficient mutants, SERT-null mutants, serotonin receptor mutants, and fluoxetine ..
  24. Characterization of Lphn3 function using a mutant murine model
    DEEANN WALLIS-SCHULTZ; Fiscal Year: 2013
    ..as other ADHD candidate genes involving the dopaminergic and serotonergic pathways including dopamine and serotonin receptors. These scant clues have been used by us to construct our research plan...
  25. Prodrugs of NAAG Peptidase Inhibitors for the Treatment of Schizophrenia
    Jia Zhou; Fiscal Year: 2009
    ..These drugs act primarily via antagonism of dopamine and serotonin receptors. However, a substantial literature supports the involvement of glutamatergic circuits in mediating the ..
  26. Mechanisms of Platelet Activation in Depression and Acute Coronary Syndromes
    Marlene S Williams; Fiscal Year: 2013
    ..Better understandings of mechanisms leading to increased risk will likely lead to more targeted and aggressive therapy and potentially improved survival. ..
  27. Neurobiological Mechanisms of Antidepressant Effects
    David A Morilak; Fiscal Year: 2013
    ..aim 2, based on our past results with antidepressant drugs, the role of 11-adrenergic receptors and 5-HT2A serotonin receptors in mPFC in the beneficial effects of CBT will be investigated, using local microinjections into mPFC...
  28. SYNAPTIC REGULATION OF ERK-MEDIATED AMYLOID-BETA METABOLISM
    John R Cirrito; Fiscal Year: 2013
    ..Recent work by our group demonstrates that activation of serotonin receptors (5HT-Rs) cause an acute reduction in brain A[unreadable] levels in mouse models of AD (Cirrito et al...
  29. Adaptation of Brainstem Circuits to Chronic Hypoxia
    DAVID DOUGLAS KLINE; Fiscal Year: 2012
    ..Results from these studies will determine the relevance and mechanism of serotonin's action in this disease model with the expectation of understanding potential therapeutic interventions. ..
  30. Control of Serotonergic Signaling by Chimeric Light Activated Receptors
    Eugene Oh; Fiscal Year: 2010
    ..role in many physiological functions and many psychiatric disorders, however the involvement of specific serotonin receptors with function and disease is largely unknown...
  31. Serotonin Modulation of Trigeminal Nociceptors
    DAYNA RUTH LOYD; Fiscal Year: 2010
    ..This project will evaluate the potential modulation of rat and human trigeminal sensory neurons by serotonin. If so, then novel drugs targeting peripheral serotonin receptors may be highly effective at treating craniofacial pain.
  32. Striatal 5-HT6 receptors, reward and addiction
    John F Neumaier; Fiscal Year: 2013
    ..of the art gene manipulations in targeted subgroups of neurons in the rat striatum to understand how 5- HT6 serotonin receptors participate in the acquisition and maintenance of reward motivated learning and cocaine self administration...
  33. Serotonin and the Rho Signaling Pathway in Smooth Muscle Cells
    BARRY FANBURG; Fiscal Year: 2010
    ..We believe the overall experiments will provide a better appreciation of 5-HT-related cell signaling pathways that may be operative in PH and may allow new approaches to therapy of this disease. ..
  34. Interneuron and motoneuron properties in chronic spinal injury
    DAVID JAMES BENNETT; Fiscal Year: 2013
    ..Modulation of this constitutive receptor activity (or lack of activity) provides a novel approach to treating spasticity while restoring lost motor function. ..
  35. Neuromodulation of midbrain frequency sensitivity by two serotonin receptors
    Laura M Hurley; Fiscal Year: 2012
    ....
  36. Functional Properties of Protein Segments in Receptors and Transporters
    Harel Weinstein; Fiscal Year: 2013
    ..assays, and a variety of 1D and 2D mutagenesis studies will be used to study loop structure and protein and/or ligand interaction of dopamine receptors and transporters, serotonin receptors, and CRF1 - a class C GPCR.
  37. Locomotion in Parasitic Nematodes
    RICHARD WALTER KOMUNIECKI; Fiscal Year: 2012
    ....
  38. Novel 5HT2C Agonist Drugs with 5HT2A Antagonist Activity for Cocaine Addiction
    Raymond G Booth; Fiscal Year: 2010
    ..This dual activity (activation/blockade) at multiple serotonin receptors is unique to (-)-trans-PAT and is hypothesized to provide pharmacological treatment for cocaine addiction ..
  39. THE EFFECTS OF COCAINE ON FETAL OXYGENATION
    James Woods; Fiscal Year: 1993
    ..3) The response of the pregnant uterus to cocaine is mediated by norepinephrine and serotonin receptors. 4) Fetal oxygen utilization is directly affected by cocaine-induced reductions in uterine blood flow...
  40. Targeting and Trafficking of 5-HT2A serotonin Receptors
    Bryan L Roth; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Drugs which target serotonin receptors are useful for treating virtually every psychiatric disorder and many major medical disorders...
  41. 5 HYDROXTRYPTAMINE MECHANISMS OF HALLUCINOGENIC DRUGS
    DAVID MOKLER; Fiscal Year: 1992
    ....
  42. New Approaches to the study of 5-HT1a autoreceptors in the raphe
    Rodrigo Andrade; Fiscal Year: 2013
    ..Previous studies have identified serotonin receptors of the 5-HT1A subtype as important regulators of the activity of serotonergic neurons...
  43. SPINAL RELEASE OF ENDORPHINS BY OPIOIDS
    LEON TSENG; Fiscal Year: 2002
    ..activation of mu opioid receptors and subsequently induced the release of 5-HT and norepinephrine acting on serotonin receptors and alpha2-adrenoceptors, respectively, in the spinal cord...
  44. Conte Centers for the Neuroscience of Depression
    Ranga R Krishnan; Fiscal Year: 2010
    ..The second project uses post mortem cell counting and cellular localization in serotonin receptors and assessment of the type of cell loss in the orbitofrontal cortex...
  45. Brain serotonin and angiotensin II systems in migraine
    JOSE TERRON; Fiscal Year: 2007
    ..5-HT content will be measured by HPLC in brain homogenates. ..
  46. Post-transcriptional Regulation of Serotonin Receptors
    RONALD EMESON; Fiscal Year: 2006
    ..It is anticipated that these studies will provide new insights concerning the regulation of cellular processes involved in the transduction of serotonergic signals and the role(s) of multiple serotonin receptors in the nervous system.
  47. Structural Domains Essential for Serotonin Receptor Pharmacology
    Bryan Roth; Fiscal Year: 2006
    ..Novel techniques of protein biochemistry (hydroxyl-mediated 1H/2H exchange), cell biology (yeast 2-hybrid screening) and spectroscopy (FRET/BRET) will be used to arrive at testable models for 5-HT2A-Gq interactions. ..
  48. Basic mechanisms of antidepressant augmentation
    Michael Newman; Fiscal Year: 2003
    ..These experiments will permit a comprehensive assessment of the role of serotonergic mechanisms in AD augmentation by T3 and an empirical basis for its use in the treatment of depression. ..
  49. DRUGS OF ABUSE IN SEROTONIN RECEPTORS KNOCKOUT MICE
    Rene Hen; Fiscal Year: 2003
    ..abstract_text> ..
  50. Serotonin receptors in the inferior colliculus
    Laura Hurley; Fiscal Year: 2006
    ..of serotonergic effects in the IC is likely to arise at least partly as a result of multiple types of serotonin receptors. The specific aims of this study are, therefore: 1) to characterize the involvement of different serotonin ..
  51. CHARACTERIZATION OF CENTRAL SEROTONERGIC RECEPTORS
    Arnold Martin; Fiscal Year: 1992
    ....
  52. SEROTONIN (5-HT) RECEPTORS AND SALIVARY GLAND FUNCTION
    GARY WEISMAN; Fiscal Year: 2002
    ....
  53. MONOAMINERGIC MODULATION OF PREFRONTAL CORTEX
    DALTON SURMEIER; Fiscal Year: 2004
    ..The ability of atypical neuroleptics to antagonize both DA receptors and serotonin receptors is generally thought to be critical to their efficacy...
  54. CORTICOSTEROID NEUROMODULATION OF SEROTONIN SYSTEM AGING
    JOAN LAKOSKI; Fiscal Year: 2004
    ..The results of these studies may lead to an indication that specific glucocorticoid antagonists may facilitate the onset of therapeutic efficacy for antidepressants in the elderly via actions at the serotonergic system. ..
  55. 5-HT2C-receptor expression and function in depression
    Claudia Schmauss; Fiscal Year: 2003
    ..These studies would attempt to assess whether the observed alteration of 5-HT2C RNA editing in depression reflects medication effects. ..
  56. REGULATION OF SEROTONIN RECEPTORS
    Paul McGonigle; Fiscal Year: 1992
    ..aim of the experiments described in this proposal is to investigate factors involved in the regulation of serotonin receptors at a cellular and molecular level...
  57. MBRS/SCORE Program at Fisk University
    WARREN COLLINS; Fiscal Year: 2004
    ..The projects will address the following: (1) Effect of lead on cognitive defects with specific emphasis on serotonin receptors; (2) Effects on lead on cognitive defects with specific emphasis on serotonin receptors; (2) Efforts to ..
  58. CHARACTERIZATION OF CENTRAL SEROTONIN RECEPTORS
    ELAINE BUSH; Fiscal Year: 2009
    ..Defining the impact of 5-HT2C receptor variation on neural signaling may lead to a better understanding of the molecular pathology of anxiety disorders and other debilitating psychiatric diseases. ..
  59. REGULATION OF BRAIN SEROTONIN RECEPTORS
    Milt Teitler; Fiscal Year: 1992
    ....
  60. MABS SPECIFIC TO SEROTONIN 5-HT RECEPTORS
    Sujay Singh; Fiscal Year: 1999
    ..5-HT receptors are also binding sites for hallucinogenic drugs. At least sixteen serotonin receptors belonging to seven subtypes have been identified...
  61. SEROTONIN RECEPTOR IMAGING DURING ANTIDEPRESSANT THERAPY
    Mark Mintun; Fiscal Year: 1999
    ..A clearer understanding of the changes in the neurotransmitter systems during pharmacological and other treatments of depression should provide an improved rationale for the development of efficacious interventions in the future. ..
  62. PEPTIDE PROBES OF THE 5HT1A RECEPTOR/G PROTEIN INTERFAC
    Keith Parker; Fiscal Year: 1999
    ..long-term goals are to study the molecular pharmacology of these receptors, especially interactions between serotonin receptors and a significant cellular signal transducing scheme, the G protein system...
  63. ASTROGLIAL SEROTONIN RECEPTORS
    Patricia Whitaker Azmitia; Fiscal Year: 1990
    ..an inhibitory growth factor, which is produced by our cultures in response to stimulation of their membrane serotonin receptors. We will also begin studies of co-cultures of astrocytes and serotonin neurons, to further elucidate this ..
  64. MECHANISMS AND REGULATION OF 5-HT RECEPTORS IN THE CNS
    Rodrigo Andrade; Fiscal Year: 1992
    ..of in vitro binding techniques, considerable progress has been made in understanding the types of serotonin receptors present in the central nervous system...
  65. 5-HT2A BINDING DIFFERENCES IN LATE LIFE DEPRESSIONS
    Yvette Sheline; Fiscal Year: 2001
    ..This information will lead to better understanding of the pathogenesis of late life depression and may contribute to improvements in antidepressants treatment design. ..
  66. ROLE OF 5-HT RECEPTORS IN DEVELOPMENT
    Patricia Whitaker Azmitia; Fiscal Year: 1990
    ..Our work suggests that this action is mediated through the presence of two high affinity serotonin receptors in the fetal brain...
  67. CANNABINOIDERGIC CONTROL OF ALCOHOL RELATED BEHAVIORS
    Basalingappa Hungund; Fiscal Year: 2006
    ..receptors for which evidence supports a direct interaction with EtOH include; GABA-A, glutamate and several serotonin receptors. Newly developed methods for targeted alteration of gene function offer the possibility of establishing a ..