chemokine receptors

Summary

Summary: Cell surface glycoproteins that bind to chemokines and thus mediate the migration of pro-inflammatory molecules. The receptors are members of the seven-transmembrane G protein-coupled receptor family. Like the CHEMOKINES themselves, the receptors can be divided into at least three structural branches: CR, CCR, and CXCR, according to variations in a shared cysteine motif.

Top Publications

  1. ncbi Involvement of chemokine receptors in breast cancer metastasis
    A Muller
    Department of Immunology, DNAX Research Institute, Palo Alto, California 94304, USA
    Nature 410:50-6. 2001
  2. ncbi Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
    F Sallusto
    Basel Institute for Immunology, Switzerland
    Nature 401:708-12. 1999
  3. ncbi The many roles of chemokines and chemokine receptors in inflammation
    Israel F Charo
    Gladstone Institute of Cardiovascular Disease and the Cardiovascular Research Institute, Department of Medicine, University of California, San Francisco, San Francisco, USA
    N Engl J Med 354:610-21. 2006
  4. ncbi CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs
    R Forster
    Molecular Tumorgenetics and Immunogenetics, Max Delbruck Center for Molecular Medicine, Berlin, Germany
    Cell 99:23-33. 1999
  5. ncbi A chemokine-driven positive feedback loop organizes lymphoid follicles
    K M Ansel
    Department of Microbiology and Immunology, University of California San Francisco, 94143, USA
    Nature 406:309-14. 2000
  6. ncbi The beta-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates
    H Choe
    Division of Human Retrovirology Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Cell 85:1135-48. 1996
  7. pmc Specific recruitment of antigen-presenting cells by chemerin, a novel processed ligand from human inflammatory fluids
    Valerie Wittamer
    Institut de Recherche en Biologie Humaine et Moléculaire, ULB Campus Erasme, 808 Route de Lennik, B 1070 Brussels, Belgium
    J Exp Med 198:977-85. 2003
  8. pmc Differential expression of chemokine receptors and chemotactic responsiveness of type 1 T helper cells (Th1s) and Th2s
    R Bonecchi
    Istituto di Ricerche Farmacologiche Mario Negri, I 20157 Milan, Italy
    J Exp Med 187:129-34. 1998
  9. ncbi International union of pharmacology. XXII. Nomenclature for chemokine receptors
    P M Murphy
    Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Pharmacol Rev 52:145-76. 2000
  10. pmc Chemokines and chemokine receptors: new insights into cancer-related inflammation
    Gwendal Lazennec
    INSERM, U844, Site Saint Eloi Bâtiment INM 80 rue Augustin Fliche, University of Montpellier I, Montpellier, F 34090, France
    Trends Mol Med 16:133-44. 2010

Detail Information

Publications371 found, 100 shown here

  1. ncbi Involvement of chemokine receptors in breast cancer metastasis
    A Muller
    Department of Immunology, DNAX Research Institute, Palo Alto, California 94304, USA
    Nature 410:50-6. 2001
    ..Here we report that the chemokine receptors CXCR4 and CCR7 are highly expressed in human breast cancer cells, malignant breast tumours and metastases...
  2. ncbi Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
    F Sallusto
    Basel Institute for Immunology, Switzerland
    Nature 401:708-12. 1999
    ....
  3. ncbi The many roles of chemokines and chemokine receptors in inflammation
    Israel F Charo
    Gladstone Institute of Cardiovascular Disease and the Cardiovascular Research Institute, Department of Medicine, University of California, San Francisco, San Francisco, USA
    N Engl J Med 354:610-21. 2006
  4. ncbi CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs
    R Forster
    Molecular Tumorgenetics and Immunogenetics, Max Delbruck Center for Molecular Medicine, Berlin, Germany
    Cell 99:23-33. 1999
    ..Thus, in order to bring together lymphocytes and dendritic cells to form the characteristic microarchitecture of secondary lymphoid organs, CCR7 is required to rapidly initiate an adoptive immune response...
  5. ncbi A chemokine-driven positive feedback loop organizes lymphoid follicles
    K M Ansel
    Department of Microbiology and Immunology, University of California San Francisco, 94143, USA
    Nature 406:309-14. 2000
    ..In germinal centres the feedback loop is overridden, with B-cell lymphotoxin alpha1beta2 expression being induced by a mechanism independent of BLC...
  6. ncbi The beta-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates
    H Choe
    Division of Human Retrovirology Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Cell 85:1135-48. 1996
    We examined the ability of chemokine receptors and related G protein-coupled receptors to facilitate infection by primary, clinical HIV-1 isolates...
  7. pmc Specific recruitment of antigen-presenting cells by chemerin, a novel processed ligand from human inflammatory fluids
    Valerie Wittamer
    Institut de Recherche en Biologie Humaine et Moléculaire, ULB Campus Erasme, 808 Route de Lennik, B 1070 Brussels, Belgium
    J Exp Med 198:977-85. 2003
    ..ChemR23 is an orphan G protein-coupled receptor related to chemokine receptors, which is expressed specifically in these cell types...
  8. pmc Differential expression of chemokine receptors and chemotactic responsiveness of type 1 T helper cells (Th1s) and Th2s
    R Bonecchi
    Istituto di Ricerche Farmacologiche Mario Negri, I 20157 Milan, Italy
    J Exp Med 187:129-34. 1998
    ..Here we report that among four CXC (CXCR1-4) and five CC (CCR1-5) chemokine receptors analyzed, CXCR3 and CCR5 are preferentially expressed in human Th1s...
  9. ncbi International union of pharmacology. XXII. Nomenclature for chemokine receptors
    P M Murphy
    Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Pharmacol Rev 52:145-76. 2000
    b>Chemokine receptors comprise a large family of seven transmembrane domain G protein-coupled receptors differentially expressed in diverse cell types...
  10. pmc Chemokines and chemokine receptors: new insights into cancer-related inflammation
    Gwendal Lazennec
    INSERM, U844, Site Saint Eloi Bâtiment INM 80 rue Augustin Fliche, University of Montpellier I, Montpellier, F 34090, France
    Trends Mol Med 16:133-44. 2010
    ..Recently, the importance of chemokines and chemokine receptors in inflammation associated with carcinogenesis has been highlighted...
  11. pmc Impaired neuropathic pain responses in mice lacking the chemokine receptor CCR2
    Catherine Abbadie
    Department of Pharmacology, Merck Research Laboratories, P O Box 2000, Rahway, NJ 07065, USA
    Proc Natl Acad Sci U S A 100:7947-52. 2003
    ..Accordingly, blockade of the CCR2 receptor may provide a novel therapeutic modality for the treatment of chronic pain...
  12. pmc Follicular B helper T cells express CXC chemokine receptor 5, localize to B cell follicles, and support immunoglobulin production
    D Breitfeld
    Molecular Tumor and Immunogenetics, Max Delbruck Center for Molecular Medicine, 13092 Berlin, Germany
    J Exp Med 192:1545-52. 2000
    ..Based on the characteristic localization within secondary lymphoid organs, we suggest to term these cells "follicular B helper T cells" (T(FH))...
  13. ncbi Blood monocytes consist of two principal subsets with distinct migratory properties
    Frederic Geissmann
    Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
    Immunity 19:71-82. 2003
    ..These findings raise the potential for novel therapeutic strategies in inflammatory diseases...
  14. pmc CXC chemokine receptor 5 expression defines follicular homing T cells with B cell helper function
    P Schaerli
    Theodor Kocher Institute, University of Bern, CH 3000 Bern 9, Switzerland
    J Exp Med 192:1553-62. 2000
    ..These properties portray CXCR5(+) T cells as a distinct memory T cell subset with B cell helper function, designated here as follicular B helper T cells (T(FH))...
  15. ncbi Chemokines and disease
    C Gerard
    Department of Pediatrics, Perlmutter Laboratory, Children s Hospital, Boston, MA, USA
    Nat Immunol 2:108-15. 2001
    ..Discussion focuses on therapeutic directions in which the rapidly evolving chemokine field appears to be headed...
  16. ncbi Identification and molecular characterization of fractalkine receptor CX3CR1, which mediates both leukocyte migration and adhesion
    T Imai
    Shionogi Institute for Medical Science, Settsu, Japan
    Cell 91:521-30. 1997
    ..Thus, fractalkine and CX3CR1 represent new types of leukocyte trafficking regulators, performing both adhesive and chemotactic functions...
  17. ncbi Langerhans cells renew in the skin throughout life under steady-state conditions
    Miriam Merad
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94304, USA
    Nat Immunol 3:1135-41. 2002
    ..These data indicate that under steady-state conditions, LCs are maintained locally, but inflammatory changes in the skin result in their replacement by blood-borne LC progenitors...
  18. ncbi Human bone marrow stromal cells express a distinct set of biologically functional chemokine receptors
    Marek Honczarenko
    Joint Program in Transfusion Medicine, Children s Hospital Boston, Harvard Medical School, Karp Family Research Bldg, RB10217, 1 Blackfan Circle, Boston, Massachusetts 02115, USA
    Stem Cells 24:1030-41. 2006
    ..In the present study, we found that second passage BMSCs express a unique set of chemokine receptors: three CC chemokine receptors (CCR1, CCR7, and CCR9) and three CXC chemokine receptors (CXCR4, CXCR5, and ..
  19. pmc Impaired monocyte migration and reduced type 1 (Th1) cytokine responses in C-C chemokine receptor 2 knockout mice
    L Boring
    Gladstone Institute of Cardiovascular Disease, University of California, San Francisco 94141 9100, USA
    J Clin Invest 100:2552-61. 1997
    ..These data suggest an important and unexpected role for CCR2 activation in modulating the immune response, as well as in recruiting monocytes/macrophages to sites of inflammation...
  20. ncbi The role of chemokine receptors in primary, effector, and memory immune responses
    F Sallusto
    Basel Institute for Immunology, Grenzacherstrasse 487, CH 4005 Basel, Switzerland
    Annu Rev Immunol 18:593-620. 2000
    ..There is growing evidence that the large families of chemokines and chemokine receptors provide a flexible code for regulating cell traffic and positioning in both homeostatic and inflammatory ..
  21. ncbi Chemokine receptors and their role in inflammation and infectious diseases
    C Murdoch
    Division of Child Health, University of Sheffield, Sheffield Children s Hospital, Sheffield, United Kingdom
    Blood 95:3032-43. 2000
    ..b>Chemokine receptors have also recently been implicated in several disease states including allergy, psoriasis, atherosclerosis, ..
  22. ncbi Decreased lesion formation in CCR2-/- mice reveals a role for chemokines in the initiation of atherosclerosis
    L Boring
    Gladstone Institute of Cardiovascular Disease, San Francisco, California 94141, USA
    Nature 394:894-7. 1998
    ..and have recently been shown to block the HIV-1 infection of target cells through interactions with chemokine receptors. In addition to their function in viral disease, chemokines have been implicated in the pathogenesis of ..
  23. ncbi TNF/iNOS-producing dendritic cells mediate innate immune defense against bacterial infection
    Natalya V Serbina
    Infectious Disease Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, Immunology Program, Sloan Kettering Institute, 1275 York Avenue, New York, NY 10021, USA
    Immunity 19:59-70. 2003
    ..Tip-DCs, as the predominant source of TNF and iNOS during L. monocytogenes infection, orchestrate and mediate innate immune defense against this intracellular bacterial pathogen...
  24. ncbi Lymphocyte traffic control by chemokines
    B Moser
    Theodor Kocher Institute, University of Bern, CH 3000 Bern 9, Switzerland
    Nat Immunol 2:123-8. 2001
    ..finely tuned by changing sets of chemokines that are selective for developmentally regulated chemokine receptors. Thus, the chemokine system assures that cell traffic during inflammatory responses occurs in the proper ..
  25. ncbi Bone marrow mesenchymal stem cells express a restricted set of functionally active chemokine receptors capable of promoting migration to pancreatic islets
    Valeria Sordi
    Telethon Juvenile Diabetes Research Foundation Center for Beta Cell Replacement, H S Raffaele Telethon Institute for Gene Therapy, and Renal Pathophysiology Laboratory, Division of Medicine, Via Olgettina 60, 20132 Milan, Italy
    Blood 106:419-27. 2005
    ..A minority of BM-MSCs (2% to 25%) expressed a restricted set of chemokine receptors (CXC receptor 4 [CXCR4], CX3C receptor 1 [CX3CR1], CXCR6, CC chemokine receptor 1 [CCR1], CCR7) and, ..
  26. ncbi A transmembrane CXC chemokine is a ligand for HIV-coreceptor Bonzo
    M Matloubian
    Department of Microbiology and Immunology, University of California San Francisco, San Francisco, CA 94143, USA
    Nat Immunol 1:298-304. 2000
    ..CXCL16 was also found in the thymic medulla and in some nonlymphoid tissues, indicating roles in thymocyte development and effector T cell trafficking...
  27. ncbi Molecular cloning of a novel human CC chemokine liver and activation-regulated chemokine (LARC) expressed in liver. Chemotactic activity for lymphocytes and gene localization on chromosome 2
    K Hieshima
    Department of Biochemistry, Kumamoto University Medical School, Honjo, Kumamoto 860, Japan
    J Biol Chem 272:5846-53. 1997
    ..4 nM and 2100 sites/cell. Collectively, LARC is a novel CC chemokine, which may represent a new group of CC chemokines localized on chromosome 2...
  28. ncbi Chemokine receptors in the central nervous system: role in brain inflammation and neurodegenerative diseases
    Laetitia Cartier
    Biology of Ageing Laboratory, Department of Geriatrics, Geneva University Hospitals, 2 Chemin du Petit Bel Air, CH 1225 Chene Bourg, Switzerland
    Brain Res Brain Res Rev 48:16-42. 2005
    ..Research over the last decade, however, has shown that chemokine receptors are not restricted to leukocytes...
  29. ncbi Cancer and the chemokine network
    Fran Balkwill
    Cancer Research UK Translational Oncology Laboratory, Barts and The London, Queen Mary s Medical School, Charterhouse Square, London EC1M 6BQ, UK
    Nat Rev Cancer 4:540-50. 2004
  30. pmc Dynamic imaging of dendritic cell extension into the small bowel lumen in response to epithelial cell TLR engagement
    Marcello Chieppa
    Lymphocyte Biology Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases NIAID, National Institutes of Health NIH, Bethesda, MD 20892, USA
    J Exp Med 203:2841-52. 2006
    ..Collectively, these findings support a model in which epithelial cell TLR signaling upon exposure to microbial stimuli induces active DC sampling of the gut lumen at sites distant from organized lymphoid tissues...
  31. ncbi Selective imprinting of gut-homing T cells by Peyer's patch dendritic cells
    J Rodrigo Mora
    The Center for Blood Research and Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 424:88-93. 2003
    ..These findings establish that Peyer's patch dendritic cells imprint gut-homing specificity on T cells, and thus license effector/memory cells to access anatomical sites most likely to contain their cognate antigen...
  32. ncbi Signal transduction by the chemokine receptor CXCR3: activation of Ras/ERK, Src, and phosphatidylinositol 3-kinase/Akt controls cell migration and proliferation in human vascular pericytes
    A Bonacchi
    Dipartimento di Medicina Interna, University of Florence, Italy
    J Biol Chem 276:9945-54. 2001
    ..These data characterize CXCR3 signaling in pericytes and clarify the relevance of downstream pathways in the modulation of different biologic responses...
  33. ncbi A putative chemokine receptor, BLR1, directs B cell migration to defined lymphoid organs and specific anatomic compartments of the spleen
    R Forster
    Max Delbruck Center for Molecular Medicine, Berlin Buch, Germany
    Cell 87:1037-47. 1996
    ..Our results identify the putative chemokine receptor BLR1 as the first G protein-coupled receptor involved in B cell migration and localization of these cells within specific anatomic compartments...
  34. ncbi Chemerin is a novel adipokine associated with obesity and metabolic syndrome
    Kiymet Bozaoglu
    Metabolic Research Unit, School of Exercise and Nutrition Sciences, Deakin University, Pigdons Road, Waurn Ponds, Geelong, Victoria 3217, Australia
    Endocrinology 148:4687-94. 2007
    ..Here we report, for the first time, that chemerin is an adipokine, and circulating levels of chemerin are associated with several key aspects of metabolic syndrome...
  35. pmc Functional specialization of gut CD103+ dendritic cells in the regulation of tissue-selective T cell homing
    Bengt Johansson-Lindbom
    Immunology Section, Lund University, BMC I 13, 221 84 Lund, Sweden
    J Exp Med 202:1063-73. 2005
    ..Collectively, these results demonstrate a unique function for LP-derived CD103+ MLN DCs in the generation of gut-tropic effector T cells...
  36. pmc A coordinated change in chemokine responsiveness guides plasma cell movements
    D C Hargreaves
    Howard Hughes Medical Institute and Department of Microbiology and Immunology, University of California at San Francisco, San Francisco, CA 94143, USA
    J Exp Med 194:45-56. 2001
    ..Our findings indicate that as B cells differentiate into plasma cells they undergo a coordinated change in chemokine responsiveness that regulates their movements in secondary lymphoid organs and promotes lodgment within the bone marrow...
  37. pmc Chemokines and chemokine receptors: standing at the crossroads of immunobiology and neurobiology
    Richard M Ransohoff
    Neuroinflammation Research Center Lerner Research Institute and Mellen Center for MS Treatment and Research Neurological Institute, Cleveland Clinic, Mail Code NC30, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Immunity 31:711-21. 2009
    ..The challenge is to integrate knowledge of the roles of key receptors (as well as their ligands) into a coherent account of events during pathologic processes, in order to guide therapeutic development...
  38. ncbi Chemokines in pathology and medicine
    M Baggiolini
    Theodor Kocher Institute, University of Bern, and Institute for Research in Biomedicine, Bellinzona, Switzerland
    J Intern Med 250:91-104. 2001
    ....
  39. ncbi Germinal center dark and light zone organization is mediated by CXCR4 and CXCR5
    Christopher D C Allen
    Howard Hughes Medical Institute and Department of Microbiology and Immunology, University of California San Francisco, San Francisco, California 94143 0414, USA
    Nat Immunol 5:943-52. 2004
    ..In contrast, CXCR5 helped direct cells to the light zone and deficiency in CXCL13 was associated with aberrant light zone localization...
  40. pmc Rules of chemokine receptor association with T cell polarization in vivo
    C H Kim
    Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of Medicine, Stanford, California, USA
    J Clin Invest 108:1331-9. 2001
    ..We conclude that the combinatorial expression of CKRs, which allow tissue- and subset-dependent targeting of effector cells during chemotactic navigation, defines physiologically significant subsets of polarized and nonpolarized T cells...
  41. ncbi Distinct differentiation potential of blood monocyte subsets in the lung
    Limor Landsman
    Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel
    J Immunol 178:2000-7. 2007
    ..Our results therefore indicate an intrinsic dichotomy in the differentiation potential of the two main blood monocyte subsets...
  42. ncbi Langerhans cells arise from monocytes in vivo
    Florent Ginhoux
    Department of Gene and Cell Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    Nat Immunol 7:265-73. 2006
    ..These results identify Gr-1(hi) monocytes as the direct precursors for LCs in vivo and establish the importance of the CSF-1 receptor in this process...
  43. pmc Excitatory monocyte chemoattractant protein-1 signaling is up-regulated in sensory neurons after chronic compression of the dorsal root ganglion
    Fletcher A White
    Department of Cell Biology, Neurobiology, and Anatomy, and Anesthesiology, Stritch School of Medicine, Loyola University Chicago, Maywood, IL 60153, USA
    Proc Natl Acad Sci U S A 102:14092-7. 2005
    ..MCP-1/CCR2 signaling is directly involved with a chronic compression injury and may contribute to associated neuronal hyperexcitability and neuropathic pain...
  44. pmc Chemokine receptor CCR7 required for T lymphocyte exit from peripheral tissues
    Gudrun F Debes
    Department of Pathology, Stanford University School of Medicine, Stanford University, Stanford, California 94305, USA
    Nat Immunol 6:889-94. 2005
    ..The regulated expression of CCR7 by tissue T lymphocytes may control their exit, acting with recruitment mechanisms to regulate lymphocyte transit and accumulation during immune surveillance and inflammation...
  45. pmc Control of cell migration in the development of the posterior lateral line: antagonistic interactions between the chemokine receptors CXCR4 and CXCR7/RDC1
    Christine Dambly-Chaudière
    Lab of Neurogenetics INSERM U881, Montpellier, France
    BMC Dev Biol 7:23. 2007
    ..sdf1a is expressed along the path of migration. There is no evidence for a gradient of sdf1a expression, however, and the origin of the directionality of migration is not known...
  46. ncbi International Union of Pharmacology. XXX. Update on chemokine receptor nomenclature
    Philip M Murphy
    Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Pharmacol Rev 54:227-9. 2002
    ..An update of the International Union of Pharmacology nomenclature for chemokines is outlined, defining one new receptor type, CXCR6, and disqualifying the putative receptor, CCR11...
  47. pmc Lymphocyte CC chemokine receptor 9 and epithelial thymus-expressed chemokine (TECK) expression distinguish the small intestinal immune compartment: Epithelial expression of tissue-specific chemokines as an organizing principle in regional immunity
    E J Kunkel
    Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA
    J Exp Med 192:761-8. 2000
    ..Selective expression of chemokines by differentiated epithelium may represent an important mechanism for targeting and specialization of immune responses...
  48. ncbi Beta-defensins: linking innate and adaptive immunity through dendritic and T cell CCR6
    D Yang
    Laboratory of Molecular Immunoregulation, Division of Basic Sciences, Intramural Research Support Program, SAIC Frederick, National Cancer Institute Frederick Cancer Research and Development Center, Frederick, MD 21702 1201, USA
    Science 286:525-8. 1999
    ..Thus, beta-defensins may promote adaptive immune responses by recruiting dendritic and T cells to the site of microbial invasion through interaction with CCR6...
  49. pmc CC chemokine receptor (CCR)4 and the CCR10 ligand cutaneous T cell-attracting chemokine (CTACK) in lymphocyte trafficking to inflamed skin
    Y Reiss
    Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Exp Med 194:1541-7. 2001
    ..We conclude that CTACK and CCR4 can both support homing of T cells to skin, and that either one or the other is required for lymphocyte recruitment in cutaneous delayed type hypersensitivity...
  50. pmc Severe reduction in leukocyte adhesion and monocyte extravasation in mice deficient in CC chemokine receptor 2
    W A Kuziel
    Department of Pathology and Laboratory Medicine, University of North Carolina Medical School, 702 Brinkhous Bullitt Building, Chapel Hill, NC 27599 7525, USA
    Proc Natl Acad Sci U S A 94:12053-8. 1997
    ..These results demonstrate that CCR2 is a major regulator of induced macrophage trafficking in vivo...
  51. ncbi C5L2 is a functional receptor for acylation-stimulating protein
    David Kalant
    Mike Rosenbloom Laboratory for Cardiovascular Research, Division of Cardiology, Department of Medicine, McGill University Health Centre, Montreal, Quebec H3A 1A1, Canada
    J Biol Chem 280:23936-44. 2005
    ..This is the first demonstration that C5L2 is a functional receptor, mediating ASP triglyceride stimulation...
  52. pmc An alternatively spliced variant of CXCR3 mediates the inhibition of endothelial cell growth induced by IP-10, Mig, and I-TAC, and acts as functional receptor for platelet factor 4
    Laura Lasagni
    Department of Clinical Pathophysiology, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy
    J Exp Med 197:1537-49. 2003
    ....
  53. ncbi The chemokine TECK is expressed by thymic and intestinal epithelial cells and attracts double- and single-positive thymocytes expressing the TECK receptor CCR9
    M A Wurbel
    Centre d Immunologie INSERM CNRS de Marseille Luminy, Marseille, France
    Eur J Immunol 30:262-71. 2000
    ..In conclusion, the interplay of TECK and its receptor CCR9 is likely to have a significant role in the recruitment of developing thymocytes to discrete compartments of the thymus...
  54. pmc Resistance to experimental autoimmune encephalomyelitis in mice lacking the CC chemokine receptor (CCR)2
    L Izikson
    Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Exp Med 192:1075-80. 2000
    ..normal T cell expressed and secreted), MCP-1, and interferon (IFN)-inducible protein 10 (IP-10) as well the chemokine receptors CCR1, CCR2, and CCR5...
  55. ncbi Chemokines and chemokine receptors: their manifold roles in homeostasis and disease
    Yingying Le
    Laboratory of Molecular Immunoregulation, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, Maryland 21702, USA
    Cell Mol Immunol 1:95-104. 2004
    ..Therefore, chemokines and their receptors are important targets for modulation of host responses in pathophysiological conditions and for therapeutic intervention of human diseases...
  56. pmc Decreased atherosclerosis in CX3CR1-/- mice reveals a role for fractalkine in atherogenesis
    Philippe Lesnik
    Gladstone Institute of Cardiovascular Disease, San Francisco, California 94141, USA
    J Clin Invest 111:333-40. 2003
    ..CX(3)CR1(-/-) mice have a significant reduction in macrophage recruitment to the vessel wall and decreased atherosclerotic lesion formation. Taken together, these data provide strong evidence that FK plays a key role in atherogenesis...
  57. ncbi Rapid and coordinated switch in chemokine receptor expression during dendritic cell maturation
    F Sallusto
    Basel Institute for Immunology, Switzerland
    Eur J Immunol 28:2760-9. 1998
    ..These different patterns of chemokine receptors are consistent with "inflammatory" and "primary response" phases of DC function.
  58. ncbi Chemokines and chemokine receptors in leukocyte trafficking
    Timothy S Olson
    Department of Molecular Physiology, University of Virginia, Charlottesville, VA 22908, USA
    Am J Physiol Regul Integr Comp Physiol 283:R7-28. 2002
    ..This review draws on recent experimental findings as well as current models proposed by experts in the chemokine field...
  59. pmc Role of ChemR23 in directing the migration of myeloid and plasmacytoid dendritic cells to lymphoid organs and inflamed skin
    William Vermi
    Department of Pathology, University of Brescia, 25123 Brescia, Italy
    J Exp Med 201:509-15. 2005
    ....
  60. ncbi The biology of chemokines and their receptors
    D Rossi
    PharMingen Inc, San Diego, California 92121 1111, USA
    Annu Rev Immunol 18:217-42. 2000
    ..and EST databases has been primarily responsible for the identification of many new chemokines and chemokine receptors. The chemokine field has also received considerable attention since chemokine receptors were found to act ..
  61. pmc Selective generation of gut tropic T cells in gut-associated lymphoid tissue (GALT): requirement for GALT dendritic cells and adjuvant
    Bengt Johansson-Lindbom
    Immunology Section, Dept of Cell and Molecular Biology, Lund University, BMC I 13, S 22184 Lund, Sweden
    J Exp Med 198:963-9. 2003
    ..Together, these results demonstrate that GALT DCs and T cell expression of CCR9 play critical and integrated roles during T cell homing to the gut...
  62. ncbi Chemokines as regulators of T cell differentiation
    S A Luther
    Howard Hughes Medical Institute and Department of Microbiology and Immunology, University of California San Francisco, 513 Parnassus Ave, San Francisco, CA 94143 0414, USA
    Nat Immunol 2:102-7. 2001
    ..Models to account for the action of chemokines and G protein-coupled receptor signals in regulating T cell differentiation are discussed...
  63. ncbi Specialized roles of the chemokine receptors CCR1 and CCR5 in the recruitment of monocytes and T(H)1-like/CD45RO(+) T cells
    C Weber
    Institut für Prophylaxe der Kreislaufkrankheiten, Medizinische Poliklinik, and Institut für Immunologie, Ludwig Maximilians Universitat Munchen, Munich, Germany
    Blood 97:1144-6. 2001
    ....
  64. ncbi Expression of chemokine receptor CCR7 is associated with lymph node metastasis of gastric carcinoma
    Kohjiro Mashino
    Department of Surgery, Medical Institute of Bioregulation, Kyushu University, 4546 Tsurumibaru, Beppu 874 0838, Japan
    Cancer Res 62:2937-41. 2002
    ..These results indicated that CCR7 and its ligands interaction is associated with preferential lymph node metastasis of gastric carcinoma...
  65. ncbi Chemokine receptor CCR7 guides T cell exit from peripheral tissues and entry into afferent lymphatics
    Shannon K Bromley
    Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Nat Immunol 6:895-901. 2005
    ..Delivery of both CCR7(+) and CCR7(-) T cells directly into the airways showed that only CCR7(+) T cells exited the lung and entered draining lymph nodes. Our study establishes a molecular basis for T cell exit from peripheral tissues...
  66. pmc Cloning, expression, and characterization of the human eosinophil eotaxin receptor
    B L Daugherty
    Department of Inflammation Research, Merck Research Laboratories, Rahway, New Jersey 07065, USA
    J Exp Med 183:2349-54. 1996
    ..Eosinophils also express a much lower level of a second chemokine receptor, CC CKR1, which appears to be responsible for the effects of MIP-1 alpha...
  67. ncbi Unique subpopulations of CD56+ NK and NK-T peripheral blood lymphocytes identified by chemokine receptor expression repertoire
    J J Campbell
    Joint Program in Transfusion Medicine, Children s Hospital, 300 Longwood Avenue, Room BD 401, Boston, MA 02115
    J Immunol 166:6477-82. 2001
    ..These findings describe a diverse population of cells that may have trafficking patterns entirely different from each other, and from other lymphocyte types...
  68. ncbi The role of chemerin in the colocalization of NK and dendritic cell subsets into inflamed tissues
    Silvia Parolini
    Section of Histology, University of Brescia, 25123 Brescia, Italy
    Blood 109:3625-32. 2007
    ..These findings propose a role for the ChemR23/chemerin axis in the recruitment of blood NK cells and strongly implicate chemerin as a key factor for the colocalization of NK cells and DC subsets in pathologic peripheral tissues...
  69. ncbi Chemokine receptors
    R Horuk
    Department of Immunology, Berlex Bioscience, 15049 San Pablo Avenue, Richmond, CA 94804, USA
    Cytokine Growth Factor Rev 12:313-35. 2001
    ..In addition, chemokine receptors play an important role in the pathogenesis of the AIDS virus, HIV-1...
  70. ncbi The chemokine receptor CCR4 in vascular recognition by cutaneous but not intestinal memory T cells
    J J Campbell
    Department of Pathology, Stanford University School of Medicine, California 94305, USA
    Nature 400:776-80. 1999
    ..Our results suggest that CCR4 and TARC are important in the recognition of skin vasculature by circulating T cells and in directing lymphocytes that are involved in systemic as opposed to intestinal immunity to their target tissues...
  71. ncbi Expression of CC chemokine receptor-7 and regional lymph node metastasis of B16 murine melanoma
    H E Wiley
    Dermatology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Natl Cancer Inst 93:1638-43. 2001
    ..CONCLUSION: Expression of a single chemokine receptor gene, CCR7, increased B16 cell metastasis to draining lymph nodes, suggesting that cancer cells may co-opt normal mechanisms of lymph node homing during metastasis...
  72. ncbi Peripheral chemokine receptors, their ligands, cytokines and Alzheimer's disease
    Marcella Reale
    Department of Oncology and Neuroscience, University G D Annunzio, Chieti, Italy
    J Alzheimers Dis 14:147-59. 2008
    ..and mitogen stimulated production of peripheral blood mononuclear cell (PBMC) cytokines, chemokines and chemokine receptors in clinically diagnosed patients with AD were unregulated...
  73. pmc CC chemokine receptor (CCR)2 is required for langerhans cell migration and localization of T helper cell type 1 (Th1)-inducing dendritic cells. Absence of CCR2 shifts the Leishmania major-resistant phenotype to a susceptible state dominated by Th2 cytokin
    N Sato
    South Texas Veterans Health Care System, Audie L Murphy Division, Austin, 78712 1095, USA
    J Exp Med 192:205-18. 2000
    ..major-susceptible genetic background. Thus, CCR2 is an important determinant of not only DC migration and localization but also the development of protective cell-mediated immune responses to L. major...
  74. ncbi Interactions of chemokines and chemokine receptors mediate the migration of mesenchymal stem cells to the impaired site in the brain after hypoglossal nerve injury
    Jun Feng Ji
    Department of Anatomy, Faculty of Medicine, National University of Singapore, Singapore
    Stem Cells 22:415-27. 2004
    ..found that rMSCs express CXCR4 and CX3CR1, the respective receptors for SDF-1 and fractalkine, and other chemokine receptors, CCR2 and CCR5...
  75. pmc The chemokine receptors CCR2 and CX3CR1 mediate monocyte/macrophage trafficking in kidney ischemia-reperfusion injury
    Li Li
    Division of Nephrology, Department of Medicine, University of Virginia, Charlottesville, Virginia 22908, USA
    Kidney Int 74:1526-37. 2008
    ..Our study shows that inflamed monocyte migration, through CCR2- and CX3CR1-dependent mechanisms, plays a critical role in kidney injury following ischemia reperfusion...
  76. pmc Chemotaxis, chemokine receptors and human disease
    Tian Jin
    Chemotaxis Signal Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, NIH, Twinbrook II Facility, 12441 Parklawn Drive, Rockville, MD 20852, USA
    Cytokine 44:1-8. 2008
    ..chemokines, serves as the extracellular signals and a family of G-protein-coupled receptors (GPCRs), chemokine receptors, detects gradients of chemokines and guides cell movement in vivo...
  77. pmc Chemokine requirements for B cell entry to lymph nodes and Peyer's patches
    Takaharu Okada
    Howard Hughes Medical Institute and Department of Microbiology and Immunology, University of California San Francisco, San Francisco, CA 94143, USA
    J Exp Med 196:65-75. 2002
    ..These findings establish the principal chemokine and chemokine receptor requirements for B cell entry to lymph nodes and Peyer's patches...
  78. pmc CCL25 mediates the localization of recently activated CD8alphabeta(+) lymphocytes to the small-intestinal mucosa
    Marcus Svensson
    Immunology Section, Department of Cell and Molecular Biology, Lund University, Lund, Sweden
    J Clin Invest 110:1113-21. 2002
    ....
  79. ncbi Towards in situ tissue repair: human mesenchymal stem cells express chemokine receptors CXCR1, CXCR2 and CCR2, and migrate upon stimulation with CXCL8 but not CCL2
    Jochen Ringe
    Tissue Engineering Laboratory, Department of Rheumatology, Charite University Medicine Berlin, Berlin, Germany
    J Cell Biochem 101:135-46. 2007
    ..The expression profile of all 18 chemokine receptors was determined by real-time PCR and immunohistochemistry...
  80. ncbi Chemokine receptors as HIV-1 coreceptors: roles in viral entry, tropism, and disease
    E A Berger
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Annu Rev Immunol 17:657-700. 1999
    ..The chemokine receptors CXCR4 and CCR5, members of the G protein-coupled receptor superfamily, have been identified as the ..
  81. pmc CC chemokine receptor 2 is critical for induction of experimental autoimmune encephalomyelitis
    B T Fife
    Department of Pathology, Northwestern University Medical School, Chicago, Illinois 60611, USA
    J Exp Med 192:899-905. 2000
    ..These results suggest that CCR2 expression on host-derived mononuclear cells is critical for disease induction...
  82. ncbi Association of CC chemokine receptor 7 with lymph node metastasis of esophageal squamous cell carcinoma
    Yongzeng Ding
    Department of Surgery and Surgical Basic Science, Graduate School of Medicine, Kyoto University, Kyoto 606 8507, Japan
    Clin Cancer Res 9:3406-12. 2003
    ..Recent studies have shown that CCR7 is involved in metastasis in some malignant diseases. The role of CCR7 in esophageal squamous cell carcinoma (SCC) has not yet been clarified...
  83. ncbi Chemotactic responsiveness toward ligands for CXCR3 and CXCR4 is regulated on plasma blasts during the time course of a memory immune response
    Anja E Hauser
    Deutsches Rheuma ForschungsZentrum Berlin, Germany
    J Immunol 169:1277-82. 2002
    ..e., CXCR3 and CXCR4, in the regulation of plasma blast migration into the bone marrow and/or inflamed tissues...
  84. ncbi Molecular cloning of human eotaxin, an eosinophil-selective CC chemokine, and identification of a specific eosinophil eotaxin receptor, CC chemokine receptor 3
    M Kitaura
    Shionogi Institute for Medical Science, Osaka, Japan
    J Biol Chem 271:7725-30. 1996
    ....
  85. pmc B cell-attracting chemokine 1, a human CXC chemokine expressed in lymphoid tissues, selectively attracts B lymphocytes via BLR1/CXCR5
    D F Legler
    Theodor Kocher Institute, University of Bern, CH 3000 Bern 9, Switzerland
    J Exp Med 187:655-60. 1998
    ..respond to several different chemokines, there is virtually no information on chemokine activities and chemokine receptors in B lymphocytes...
  86. pmc Molecular basis for hematopoietic/mesenchymal interaction during initiation of Peyer's patch organogenesis
    K Honda
    Department of Molecular Genetics, Graduate School of Medicine, Kyoto University, Syogoin Kawaharacho 53, Sakyo ku, Kyoto 606 8507, Japan
    J Exp Med 193:621-30. 2001
    ..Thus, promotion of PP development relies on mutual interaction between mesenchymal and lymphoid cells...
  87. ncbi Distinct patterns and kinetics of chemokine production regulate dendritic cell function
    F Sallusto
    Basel Institute for Immunology, Switzerland
    Eur J Immunol 29:1617-25. 1999
    ..The time-ordered production of inflammatory and constitutive chemokines provides DC with the capacity to self-regulate their migratory behavior as well as to recruit other cells for the afferent and efferent limb of the immune response...
  88. ncbi Chemokine receptor CCR7 induces intracellular signaling that inhibits apoptosis of mature dendritic cells
    Noelia Sanchez-Sanchez
    Centro de Investigaciones Biologicas, Consejo Superior de Investigaciones Cientificas, Madrid, Spain
    Blood 104:619-25. 2004
    ..In summary, in addition to its well-established role in chemotaxis, we show that CCR7 also induces antiapoptotic signaling in mature DCs...
  89. ncbi Chemokines and chemokine receptors: an overview
    Raffaella Bonecchi
    Department of Translational Medicine, University of Milan, IRCCS Istituto Clinico Humanitas, I 20089 Rozzano, Italy
    Front Biosci (Landmark Ed) 14:540-51. 2009
    ..Here we analyze the chemokine system, with particular attention to available information on clinical situations in which chemokines or their receptors might assume diagnostic value...
  90. ncbi An anti-inflammatory function for the complement anaphylatoxin C5a-binding protein, C5L2
    Norma P Gerard
    Pulmonary Division, Department of Pediatrics, Children s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 280:39677-80. 2005
    ..Accordingly, up-regulation of C5L2 may be of benefit in inflammatory states driven by C5a, including sepsis, asthma, cystic fibrosis, and chronic obstructive lung disease...
  91. ncbi Monocyte emigration from bone marrow during bacterial infection requires signals mediated by chemokine receptor CCR2
    Natalya V Serbina
    Infectious Disease Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, Immunology Program, Sloan Kettering Institute, New York, New York 10021, USA
    Nat Immunol 7:311-7. 2006
    ..Thus, CCR2-mediated signals in bone marrow determine the frequency of Ly6C(hi) monocytes in the circulation...
  92. ncbi Control of microglial neurotoxicity by the fractalkine receptor
    Astrid E Cardona
    Neuroinflammation Research Center and Department of Neurosciences, Lerner Research Institute, Cleveland, Ohio 44195, USA
    Nat Neurosci 9:917-24. 2006
    ..Augmenting CX3CR1 signaling may protect against microglial neurotoxicity, whereas CNS penetration by pharmaceutical CX3CR1 antagonists could increase neuronal vulnerability...
  93. pmc Human immunodeficiency virus type 1 uses lipid raft-colocalized CD4 and chemokine receptors for productive entry into CD4(+) T cells
    Waldemar Popik
    Oncology Center, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
    J Virol 76:4709-22. 2002
    ..Colocalization of CCR5 with GM1 and gp120 upon engagement of CD4 and CXCR4 by HIV-1 further supports our observation that HIV-1 receptors localize to the same lipid rafts in PM1 T cells...
  94. ncbi Expression of chemokine receptors predicts the site of metastatic relapse in patients with axillary node positive primary breast cancer
    F Andre
    Department of Medicine and Translational Research Unit UPRES03535, Institut Gustave Roussy, Villejuif, France
    Ann Oncol 17:945-51. 2006
    Recent studies have suggested that chemokine receptors are involved in development of organ-specific pattern of metastases...
  95. ncbi CCR7 expression and memory T cell diversity in humans
    J J Campbell
    Joint Program in Transfusion Medicine, Children s Hospital, and Harvard Medical School, Department of Pathology, Boston, MA 02115, USA
    J Immunol 166:877-84. 2001
    ..The ratio of CD27(neg)/CCR7(neg) cells to CD27(pos)/CCR7(pos) cells varies from tissue to tissue, and may correlate with the number of cells actively engaged in Ag recognition within a given tissue...
  96. ncbi Differential regulation of eosinophil chemokine signaling via CCR3 and non-CCR3 pathways
    I Sabroe
    Leukocyte Biology Section, Biomedical Sciences Division, Imperial College School of Medicine, South Kensington, London, United Kingdom
    J Immunol 162:2946-55. 1999
    ..The observed up-regulation of MIP-1alpha signaling via non-CCR3 pathways may play a role in eosinophil recruitment in inflammatory states such as occurs in the asthmatic lung...
  97. pmc Cloning of the human eosinophil chemoattractant, eotaxin. Expression, receptor binding, and functional properties suggest a mechanism for the selective recruitment of eosinophils
    P D Ponath
    LeukoSite, Inc, Cambridge, Massachusetts 02142, USA
    J Clin Invest 97:604-12. 1996
    ..Thus eotaxin in humans is a potent and selective eosinophil chemoattractant that is expressed by a variety cell types in certain inflammatory conditions...
  98. ncbi CCR2 expression determines T1 versus T2 polarization during pulmonary Cryptococcus neoformans infection
    T R Traynor
    Pulmonary Division, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA
    J Immunol 164:2021-7. 2000
    ..neoformans infection and lack of CCR2 results in a switch to a T2-type response. Thus, CCR2 plays a critical role in promoting the development of T1- over T2-type immune responses in the lung following cryptococcus infection...
  99. ncbi Human mesenchymal stem cells constitutively express chemokines and chemokine receptors that can be upregulated by cytokines, IFN-beta, and Copaxone
    Juliana Croitoru-Lamoury
    Centre for Immunology, St Vincent s Hospital, Department of Neurology, Sydney NSW, Australia
    J Interferon Cytokine Res 27:53-64. 2007
    ..We, therefore, systematically assessed the expression and modulating factors for chemokines and chemokine receptors in human MSCs (HuMSCs)...
  100. ncbi Chemokine receptors in advanced breast cancer: differential expression in metastatic disease sites with diagnostic and therapeutic implications
    N Cabioglu
    Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77230, USA
    Ann Oncol 20:1013-9. 2009
    ....
  101. ncbi Mice with a selective deletion of the CC chemokine receptors 5 or 2 are protected from dextran sodium sulfate-mediated colitis: lack of CC chemokine receptor 5 expression results in a NK1.1+ lymphocyte-associated Th2-type immune response in the intestine
    P G Andres
    Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    J Immunol 164:6303-12. 2000
    The chemokine receptors CCR2 and CCR5 and their respective ligands regulate leukocyte chemotaxis and activation...

Research Grants76

  1. Suppression of pathogenic autoantibodies in lupus by inhibition of AID
    John D Mountz; Fiscal Year: 2012
    ..Upregulation of these genes decrease, rather than increase, the signaling to the CXCR4 and CXCR5 chemokine receptors expressed on GC B and T cells. In this application, we will address the following questions...
  2. A novel allele influencing HIV infection among injection drug users
    Xiao Fang Yu; Fiscal Year: 2012
    ..to those of polyphorphisms in other host genetic factors, including HLA alleles, chemokines, and chemokine receptors. The proposed research is both innovative and significant in that it utilizes a unique population of ..
  3. Immune Mechanisms That Control Ectromelia Virus Infection
    Luis J Sigal; Fiscal Year: 2013
    ..In Aim 2 we will determine the chemokines and chemokine receptors expressed at the site of ECTV infection in resistant or susceptible mice, and the chemokines that are ..
  4. Naturally Occurring IgM Anti-Leucocyte Autoantibodies Protect Against Renal IRI
    MARK DOUGLAS OKUSA; Fiscal Year: 2013
    ..production of certain proinflammatory cytokines (TNF-1, IL-2) but not others (IL-6 and IL-8), (ii) bind to chemokine receptors and inhibit chemotaxis...
  5. CHEMOKINE RECEPTOR DYNAMICS IN GRANULOMA FORMATION
    Stephen W Chensue; Fiscal Year: 2013
    ..role of chemoattractant proteins in these responses with the objective to identify critical chemokines and chemokine receptors required for effective and appropriate responses to these pathogens...
  6. Homing Receptor Determinants of HSC
    Irving L Weissman; Fiscal Year: 2013
    ..Under this grant, we have made several surprising findings. First, we identified the homing receptors and chemokine receptors used by HSC to home from blood to marrow hematopoiesis sites...
  7. Targeting fibrocytes in Duchenne muscular dystrophy
    Lan Zhou; Fiscal Year: 2013
    ..We further showed that mdx diaphragm fibrocytes expressed chemokine receptors CCR1, CCR2, CCR5, and CXCR4...
  8. Definition of an Ancient T cell-like System in Lampreys
    MAX DALE COOPER; Fiscal Year: 2013
    ..transcriptomes to obtain information about the differential expression of cytokines, chemokines, cytokine/chemokine receptors, cytolytic components, VLR co-receptor candidates, co-stimulatory molecules, signaling elements, and ..
  9. Immunosuppression by Adult Stem Cells
    Yufang Shi; Fiscal Year: 2013
    ..Blockade of NO production or chemokine receptors reversed the inhibition of T cells...
  10. Cellular and molecular mechanisms of gp120 neurotoxicity
    Italo Mocchetti; Fiscal Year: 2012
    ..The neurotoxic effect of gp120 occurs through chemokine receptors. Preliminary evidence has shown that the chemokine receptor CXCR4 promotes endocytosis of T-tropic gp120 ..
  11. Role of the Angiogenic Chemokine, CXCL5, in Prostate Cancer
    Liz Simon; Fiscal Year: 2012
    ..However, it has been demonstrated that tumor cells express chemokine receptors and/or their ligands that facilitate tumor cell survival, growth and migration...
  12. Id3/B Lymphocytes and Atherosclerosis
    Coleen A McNamara; Fiscal Year: 2010
    ..that Id3 regulates B cell expression of specific chemokines: CXCR4, CXCR7, and CCR6 but not CXCR5 or CCR7 (chemokine receptors known to regulate B cell homing to lymphoid tissue), providing a potential mechanism whereby Id3 may ..
  13. Personalized therapeutics for inhibiting breast cancer metastasis
    DEBRA AUGUSTE; Fiscal Year: 2012
    ..clinical trials, this method has the advantage of localizing within tumors, cooperatively binding multiple chemokine receptors, blocking chemotaxis, delivering Lcn2 siRNA to impede the EMT, and monitoring biodistribution in vivo via ..
  14. Synthetic Fabs for Crystallization of Chemokine:Receptor Complexes
    Tracy M Handel; Fiscal Year: 2013
    ..As allosteric membrane proteins, chemokine receptors like other GPCRs are intrinsically unstable and dynamic by nature, which has made them difficult structural ..
  15. Role of mast cells in obesity
    Guo Ping Shi; Fiscal Year: 2012
    ..2). To identify which chemokine receptors that mast cells use for homing to the adipose tissues and to identify which of those common mast cell ..
  16. Genetic Regulation of B Lymphocyte Aortic Homing and Atheroprotection
    Coleen A McNamara; Fiscal Year: 2013
    ..the helix-loop-helix factor (HLH), Id3, as a novel atheroprotective factor that regulates expression of chemokine receptors and aortic homing of B lymphocytes and demonstrated that Id3 was essential for B lymphocyte-mediated ..
  17. Dermatotropic cellular immune responses induced by a novel smallpox vaccine
    Stephen R Walsh; Fiscal Year: 2013
    ..lymphocyte homing molecules, including the cutaneous lymphocyte-associated antigen (CLA) and specific chemokine receptors such as CCR4 and CCR10...
  18. Drugs of Abuse Affecting AIDS Pathogenesis
    Thomas J Rogers; Fiscal Year: 2012
    ..address the combined influence of morphine and SIV infection on the expression of critical chemokines and chemokine receptors that play an important role in the development of SIV encephalitis...
  19. Insulin-Like Growth Factor-1 and Atherosclerosis
    Patrice Delafontaine; Fiscal Year: 2013
    ..We will examine mechanisms whereby IGF-1 exerts these effects and in particular the roles of chemokine receptors (CCR1, CCR2) and of 12/15-lipoxygenase and lipoprotein lipase...
  20. Interferon Effects on HIV Transmission in Human Models
    Judy Lieberman; Fiscal Year: 2013
    ..activation status of CD4 T cells in the genital mucosa, the recruitment of immune cells to the tissue and the expression of cytokines and chemokines and chemokine receptors that regulate immune cell ingress and egress from the tissue.
  21. Transcriptional control of chemokine receptors and naive T cell trafficking
    Eric Sebzda; Fiscal Year: 2013
    ..naive and effector T cells respond to diverse chemokine gradients via homeostatic and inflammatory chemokine receptors (CRs), respectively...
  22. HS1 Function in Dendritic Cells
    Deborah A Klos Dehring; Fiscal Year: 2010
    ..Flow cytometry and transwell assays will identify the chemokine receptors expressed on the HS1-/- DCs and the effects of HS1- deficiency on migration towards specific chemokines...
  23. Function and Targeting of CCR6/CCL20 in Autoimmune Psoriasiform Skin Disease
    Sam T Hwang; Fiscal Year: 2013
    ..Among the ~20 known chemokine receptors, CC chemokine receptor-6 (CCR6) is particularly important for Th17-directed immune activity since it is ..
  24. Regulation of CXCR4 by cognate and non-cognate ligands
    Elias Lolis; Fiscal Year: 2013
    ..the chemokine superfamily as defined by their sequence and structure and would be expected to interact with chemokine receptors. More recently, a non-cognate protein, macrophage migration inhibitory protein (MIF), was reported to ..
  25. Immunodominant Stress Proteins of Porphyromonas gingivalis
    Dennis E Lopatin; Fiscal Year: 2010
    ..In periodontitis P. gingivalis HtpG recruits antibody producing cells to the lesion and upregulates chemokine receptors on both leukocytes and vascular cells contributing to the continuning tissue destruction...
  26. Structure-Function Studies &Molecular Interactions of Chemokines
    Tracy M Handel; Fiscal Year: 2013
    ..migration is a complex multistep process involving many different interactions, not only of chemokines with chemokine receptors, but also with glycosaminoglycans (GAGs) and with each other through homo- and hetero-oligomerization...
  27. Structural Biology of G-Protein Coupled Receptors
    Wayne A Hendrickson; Fiscal Year: 2011
    ..5HT) notably receptor 5HT2c;the human glycoprotein hormone receptors, FSHR and LHR;and human chemokine receptors that are co-opted by HIV, CCR5 and CXCR4. Continued studies are also planned for other GPCRs...
  28. Epithelia Associated Dendritic Cells: Phenotype and Function
    Rodney D Newberry; Fiscal Year: 2010
    ..to define the EA-DC subtypes and examine these cells for the expression of toll like receptors and chemokine receptors. The morphology of these EA-DC subtypes will be evaluated with electron microscopy...
  29. Treg Migration in GVHD
    Jonathan Serody; Fiscal Year: 2009
    ..Additionally, we have recently shown that Treg cells express a different pattern of chemokine receptors after activation, that the chemokine receptor, CCR5, is markedly increased after activation, and that the ..
  30. Characterization of CCL28,CXCL14, and CXCL17, three mucosal chemokines
    Albert Zlotnik; Fiscal Year: 2013
    ..Importantly, through these experiments we will identify a new chemokine receptor. Other chemokine receptors have been implicated in human diseases, and represent potential targets for pharmaceutical development...
  31. T Cell Memory in Organ Transplantation
    Fadi G Lakkis; Fiscal Year: 2010
    ..Congenic markers will be used to track adoptively transferred CD8 memory T cells. Gene knockout mice and monoclonal antibodies will be used to examine the roles of chemokine receptors and adhesion molecules.
  32. Transnasal Delivery of Chemokine Analogs in mouse NeuroAIDS Models
    Stuart A Lipton; Fiscal Year: 2013
    ..As potential treatment, we and our collaborators have synthesized new peptide inhibitors of chemokine receptors (CXCR4 and CCR5, which are co-receptors for HIV/gp120), and found that these novel synthetically and ..
  33. New tools to study leukocyte infiltration into the CNS
    CHARLES LEE HOWE; Fiscal Year: 2013
    ..Based on this concept, and in an effort to dissect the role of specific chemokine receptors in the trafficking of myelomonocytic cells to the CNS, our first objective in this small grant proposal is ..
  34. CHEMOKINE RECEPTOR FUNCTION IN THE NERVOUS SYSTEM
    Richard J Miller; Fiscal Year: 2013
    ..funding period we determined that neural stem cells in the developing and adult nervous systems expressed chemokine receptors and that chemokines were important in regulating the directed migration and development of these cells...
  35. Initiation of the Immune Response to M. tuberculosis
    Joel D Ernst; Fiscal Year: 2012
    ..mediastinal lymph node for initiation of the adaptive immune response, we will test the hypothesis that the chemokine receptors CCR7 and CCR8 mediate migration of mature DCs from the lungs to the mediastinal lymph node...
  36. Balance of chemokine entry and exit signals controls T cell accumulation in skin
    Shannon K Bromley; Fiscal Year: 2010
    ..the consequence of effector/memory T cell antigen recognition in peripheral tissues on their expression of chemokine receptors and their retention in skin versus migration into afferent lymph;3) Attempt to override the balance in ..
  37. Somatic Diversification of Immunoglobulin Genes in GALT
    Katherine L Knight; Fiscal Year: 2013
    ..The goal of this grant is to test this model of GALT development. In Aim 1 we will use soluble chemokine receptors to inhibit chemokine-driven migration and determine how the migration of B cells is altered;in Aim 2, we ..
  38. Sequential Control of Neutrophil Recruitment by LTB4 and Other Chemoattractants
    Andrew D Luster; Fiscal Year: 2013
    ..the asthmatic airway, initially directed by the leukotriene B4 (LTB4) receptor BLT1 and subsequently by chemokine receptors. In this period, we have also discovered that neutrophil synthesis of LTB4 and BLT1-induced neutrophil ..
  39. Molecular characterization of T-bet's role in immunity
    AMY SUSAN WEINMANN; Fiscal Year: 2013
    ..Previous work has shown that T-bet positively regulates the effector cytokines and chemokine receptors that are the prototypic genes in Th1 cellular differentiation...
  40. Environmental Control of the Immunological Synapse
    MICHAEL LORAN DUSTIN; Fiscal Year: 2013
    ..b>Chemokine receptors are a major class of G-protein coupled receptors and CCR7 is the most important member of this class of ..
  41. Chemokines, TRP Channels and Cancer Pain
    Durga Prasanna Mohapatra; Fiscal Year: 2013
    ..We also show that, sustained activation of these chemokine receptors in sensory neurons upregulate the expression of TRPV1 protein, and might decrease the temperature-..
  42. HIV drug abusers, polymorphisms and brain plasticity
    Italo Mocchetti; Fiscal Year: 2012
    ..Chronic opiates alter the expression of chemokine receptors CCR5 and CXCR4, known to mediate the neurotoxic effect of HIV...
  43. AMPK and adipose tissue biology in bariatric surgery patients
    Neil B Ruderman; Fiscal Year: 2012
    ..bariatric surgery that revealed AMPK activity is lower and the expression of inflammatory markers and chemokine receptors higher in adipose tissue of patients who were insulin resistant (70 percent of total)...
  44. CXCR4 regulation of tumor progression in Multiple Myeloma
    Irene M Ghobrial; Fiscal Year: 2012
    ..and in vivo, and difference in signaling of these two receptors in MM, and identifying the role of other chemokine receptors and adhesion molecules in the regulation of homing...
  45. Chemokine regulation of liver injury and recovery
    Alex B Lentsch; Fiscal Year: 2013
    ..In addition, we hypothesize that expression of the chemokine receptors, CXCR1 and CXCR2, differs in response to these insults and that this also contributeisting therapeutic ..
  46. HTS to Identify Novel Chemical Probes for CCR6
    GREGORY PAUL ROTH; Fiscal Year: 2010
    b>Chemokine receptors are members of one of the largest gene families encoded within the human genome;the class A, rhodopsin-like, G protein coupled receptors (GPCRs)...
  47. Role of the Fractalkine Signaling in EOC
    Maria V Barbolina; Fiscal Year: 2012
    ..Chemokines are promising drug targets. Moreover, chemokine receptors are the G protein coupled receptors, a class of proteins that are effective drug targets covering an ..
  48. Infant Mycotoxin Exposure and Mucosal Immune Activation in HIV-Endemic South Afri
    Lianna F Wood; Fiscal Year: 2013
    ..adult and infant blood and oral mucosa will be used to define the network of chemokines and chemokine receptors expressed by oral mucosa cells in response to stimulation with mycotoxins...
  49. Chemokines and Th2 Cell Trafficking in Asthma
    Andrew D Luster; Fiscal Year: 2013
    ..In addition, we will determine the chemokine receptors responsible for lung-specific homing and identify the lung DC subset that imprints lung-specific homing...
  50. CHEMOKINE-MEDIATED NEUROPROTECTION AND REPAIR DURING WNV ENCEPHALITIS
    ROBYN SUE KLEIN; Fiscal Year: 2013
    ..factors that determine the neuropathogenesis and outcome of WNV encephalitis in humans, including several chemokine receptors that determine the entry and fate of infiltrating immune cells...
  51. BAFF Pathology: Novel Therapeutic Targets in Chronic Graft versus Host Disease
    Stefanie Sarantopoulos; Fiscal Year: 2013
    ..of Graft versus Host Disease (GVHD) having led several NIH-funded laboratory studies focused on the role of chemokine receptors and immune regulatory cells in GVHD...
  52. Neuroprotective roles for apelin in HIV-associated excitotoxic injury
    DENISE RAE COOK; Fiscal Year: 2011
    ..neurotoxicity demonstrates that activation of certain neuronal G-protein coupled receptors (GPCRs), such as chemokine receptors, can counteract excitotoxic neuronal injury through modulation of cell survival signaling pathways...
  53. Nanodisc Reconstitution and Characterization of Chemokine Receptors
    DAMON JUSTIN HAMEL; Fiscal Year: 2010
    ..These studies will establish a protocol for the preparation of soluble, monodisperse, and functional chemokine receptors for use in a wide array of biophysical experiments aimed at increasing our understanding of disease-related ..
  54. Molecular Characterization of T-bet's Role in Immunity
    AMY WEINMANN; Fiscal Year: 2009
    ..Previous work has shown that T-bet positively regulates the effector cytokines and chemokine receptors that are the prototypic genes in Th1 cellular differentiation...
  55. Radiotherapy as Immunotherapy of Tumors
    Samuel Strober; Fiscal Year: 2013
    ..of T cell migration to the tumors after radiotherapy by investigating chemokines produced by the tumors and chemokine receptors on the T cells that can infiltrate tumors...
  56. Mechanisms of KSHV-Induced Cellular Transformation
    Ashlee V Moses; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: Chemokines, secreted proteins that regulate cell function by binding to specific chemokine receptors (CR) on responsive cells, play an essential role in the development, growth and metastasis of human tumors ..
  57. The Role of Regulator of G-protein Signaling 10 (RGS10) in Monocyte Chemotaxis
    George T Kannarkat; Fiscal Year: 2013
    ..The process of immune cell recruitment is controlled by chemokines binding to Gay-protein coupled chemokine receptors (CRs)...
  58. Chemokine receptors and the interferon gamma pathway in Th1 cell trafficking
    Zamaneh Mikhak; Fiscal Year: 2010
    Homing of Th1 cells to sites of Th1 inflammation relies on the interaction of chemokine receptors on Th1 cells with the chemokines secreted at Th1 inflammatory sites...
  59. Modulating chemokine receptors at the blood-brain barrier under flow
    Richard M Ransohoff; Fiscal Year: 2012
    ..The overall hypothesis is that individual chemokine receptors are regulated differentially on different subsets of leukocytes, contingent on ligand availability;..
  60. Chemokines and Viral-Induced Neurologic Disease
    Thomas E Lane; Fiscal Year: 2013
    ..The long-term objective of this competitive renewal is to evaluate the functional role of chemokine and chemokine receptors in contributing to neurologic disease and repair following infection with a neurotropic murine coronavirus, ..
  61. Role of chemokine receptors in neuronal survival
    Olimpia Meucci; Fiscal Year: 2013
    ..abstract_text> ..
  62. The Role of C-C Chemokines in Eosinophil Airway Inflammation
    Nicholas W Lukacs; Fiscal Year: 2012
    ..This renewal application will focus on the role of specific chemokine receptors and their ligands in RSV infection as well as the effects of RSV on exacerbation of cockroach allergen ..
  63. HOST GENETIC DETERMINANTS OF HIV PATHOGENESIS
    Sunil Ahuja; Fiscal Year: 1999
    ..evidence supporting the hypothesis that polymorphisms in the genes encoding critical HIV entry cofactors (chemokine receptors) and their ligands, as well the major histocompatibility (MHC) proteins strongly influence HIV-1 ..
  64. Donor CD8+ cell facilitates mixed chimerism in NOD mice
    Defu Zeng; Fiscal Year: 2005
    ..host lymphohematopoietic tissues in anti-CD3-conditioned recipients is due to the lack of up-regulation of chemokine receptors including CCR5, CCR9, CCR10 and CXCR3 on donor CD8+ T cells; and the expression of chemokine receptors is ..
  65. Migration of polyomavirus JC across the blood-brain-barrier
    Vivek Nerurkar; Fiscal Year: 2009
    ..CAM), such as very late antigen-4 (VLA-4) and lymphocyte function associated-antigen-1 (LFA-1), and chemokine receptors, CCR2 and CXCR1/CXCR2, to preferentially cross the BBB...
  66. Tyrosine Sulfation and Chemokine Receptor Function
    Kevin Moore; Fiscal Year: 2006
    ..Recently, several G-protein-coupled receptors (GPCRs), including the chemokine receptors CCR2B, CXCR4, CCR5, and CX3CR1, the C5a receptor, and the TSH receptor were shown to be tyrosine sulfated ..
  67. Hydrogen Deuterium Exchange Mapping of Chemokine Receptor Complex Interfaces
    Tracy Handel; Fiscal Year: 2009
    ..Specific chemokine receptors provide the portals for HIV to get into cells, while others contribute to inflammatory disease, and ..
  68. CHEMOKINES IN CTL FUNCTION AND TRAFFICKING IN HIV
    Andrew Luster; Fiscal Year: 2004
    ..b>Chemokine receptors on CD8+ T lymphocyte have recently been implicated in their cytolytic function and survival...
  69. HIV-1 gp120 Mediated Chemotaxis of Blood Cells
    Ramesh Ganju; Fiscal Year: 2005
    DESCRIPTION: (provided by applicant) Chemokine receptors CXCR4 and CCR5 play critical roles in H1V infection...
  70. CHEMOKINES AND CHEMOKINE RECEPTORS IN SIV ENCEPHALITIS
    M Zink; Fiscal Year: 2003
    ..result in the development of HIV-associated neurological disease, particularly the roles of chemokines and chemokine receptors, are not well understood...
  71. Chemokines and Macrophages in HIV Neuronal Apoptosis
    Stuart Lipton; Fiscal Year: 2003
    ..Microglia, astrocytes and neurons express co-receptors for HIV-1, namely the chemokine receptors CCR5 and CXCR4...
  72. T CELL DEPENDENT TERMINAL MATURATION OF LANGERHANS CELLS
    Akira Takashima; Fiscal Year: 2005
    ..The specific aims are: 1) To define functional roles played by chemokines and chemokine receptors in LC migration...
  73. Chemokine Receptor Signaling in HIV Neuropathology
    Marcus Kaul; Fiscal Year: 2007
    ..The HIV-1 envelope protein gpl20 binds to macrophages, microglia and T-cells via the chemokine receptors CCR5 and CXCR4, which serve besides CD4 as co-receptors for the virus...
  74. Natural IgM antilymphocyte autoantibodies inhibit HIV-1
    PETER LOBO; Fiscal Year: 2003
    ..The latency period is determined by host factors that control viral infectivity. Chemokine receptors (CCR5 and CXCR4) serve as co-receptors for HIV-1 entry into cells...
  75. CHEMOKINE RECEPTORS AND ITP AND HIV THROMBOCYTOPE
    Shahin Rafii; Fiscal Year: 2002
    ..Identification of chemokine receptors that may regulate platelet production may elucidate pathogenesis of thrombocytopenia in HIV or other ..
  76. CHEMOKINE RECEPTORS IN VASCULAR DISEASE
    Jay Nelson; Fiscal Year: 2007
    ..In addition we have shown that chemokine receptors encoded by CMV not only induce SMC migration but also decrease the incidence and severity of ..