calcium sensing receptors

Summary

Summary: A class of G-protein-coupled receptors that react to varying extracellular CALCIUM levels. Calcium-sensing receptors in the PARATHYROID GLANDS play an important role in the maintenance of calcium HOMEOSTASIS by regulating the release of PARATHYROID HORMONE. They differ from INTRACELLULAR CALCIUM-SENSING PROTEINS which sense intracellular calcium levels.

Top Publications

  1. ncbi Cloning and characterization of an extracellular Ca(2+)-sensing receptor from bovine parathyroid
    E M Brown
    Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts
    Nature 366:575-80. 1993
  2. ncbi Extracellular calcium sensing and extracellular calcium signaling
    E M Brown
    Endocrine Hypertension Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Physiol Rev 81:239-297. 2001
  3. ncbi Calcium sensing receptors and calcium oscillations: calcium as a first messenger
    Gerda E Breitwieser
    Weis Center for Research, Geisinger Clinic, Danville, Pennsylvania 17822, USA
    Curr Top Dev Biol 73:85-114. 2006
  4. ncbi Mutations in the human Ca(2+)-sensing receptor gene cause familial hypocalciuric hypercalcemia and neonatal severe hyperparathyroidism
    M R Pollak
    Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115
    Cell 75:1297-303. 1993
  5. ncbi Calcium-sensing receptor stimulates PTHrP release by pathways dependent on PKC, p38 MAPK, JNK, and ERK1/2 in H-500 cells
    J Tfelt-Hansen
    Endocrine Hypertension Division, Dept of Medicine and Membrane Biology Program, Brigham and Women s Hospital and Harvard Medical School, 221 Longwood Ave, Boston, MA 02115, USA
    Am J Physiol Endocrinol Metab 285:E329-37. 2003
  6. ncbi Calcium-sensing receptor activation induces intracellular calcium oscillations
    G E Breitwieser
    Department of Physiology, Johns Hopkins University School of Medicine, 725 N Wolfe St, Baltimore, MD 21205, USA
    Am J Physiol Cell Physiol 280:C1412-21. 2001
  7. ncbi Autosomal dominant hypocalcaemia caused by a Ca(2+)-sensing receptor gene mutation
    M R Pollak
    Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115
    Nat Genet 8:303-7. 1994
  8. ncbi Diseases associated with the extracellular calcium-sensing receptor
    R V Thakker
    Nuffield Department of Clinical Medicine, Botnar Research Centre, Nuffield Orthopaedic Centre, University of Oxford, Headington, Oxford OX3 7LD, UK
    Cell Calcium 35:275-82. 2004
  9. ncbi Extracellular calcium and calcium sensing receptor function in human colon carcinomas: promotion of E-cadherin expression and suppression of beta-catenin/TCF activation
    Subhas Chakrabarty
    Department of Molecular Pathology, University of Texas, M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Res 63:67-71. 2003
  10. ncbi Calcium sensing receptor in human colon carcinoma: interaction with Ca(2+) and 1,25-dihydroxyvitamin D(3)
    Subhas Chakrabarty
    Department of Molecular Pathology, University of Texas, MD Anderson Cancer Center, Houston, TX 77030, USA
    Cancer Res 65:493-8. 2005

Detail Information

Publications209 found, 100 shown here

  1. ncbi Cloning and characterization of an extracellular Ca(2+)-sensing receptor from bovine parathyroid
    E M Brown
    Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts
    Nature 366:575-80. 1993
    ....
  2. ncbi Extracellular calcium sensing and extracellular calcium signaling
    E M Brown
    Endocrine Hypertension Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Physiol Rev 81:239-297. 2001
    ..In any event, the CaR and other receptors/sensors for Ca(o)(2+) and probably for other extracellular ions represent versatile regulators of numerous cellular functions and may serve as important therapeutic targets...
  3. ncbi Calcium sensing receptors and calcium oscillations: calcium as a first messenger
    Gerda E Breitwieser
    Weis Center for Research, Geisinger Clinic, Danville, Pennsylvania 17822, USA
    Curr Top Dev Biol 73:85-114. 2006
    b>Calcium sensing receptors (CaR) are unique among G-protein-coupled receptors (GPCRs) since both the first (extracellular) and second (intracellular) messengers are Ca(2+)...
  4. ncbi Mutations in the human Ca(2+)-sensing receptor gene cause familial hypocalciuric hypercalcemia and neonatal severe hyperparathyroidism
    M R Pollak
    Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115
    Cell 75:1297-303. 1993
    ..We conclude that the mammalian Ca(2+)-sensing receptor "sets" the extracellular Ca2+ level and is defective in individuals with FHH and NSHPT...
  5. ncbi Calcium-sensing receptor stimulates PTHrP release by pathways dependent on PKC, p38 MAPK, JNK, and ERK1/2 in H-500 cells
    J Tfelt-Hansen
    Endocrine Hypertension Division, Dept of Medicine and Membrane Biology Program, Brigham and Women s Hospital and Harvard Medical School, 221 Longwood Ave, Boston, MA 02115, USA
    Am J Physiol Endocrinol Metab 285:E329-37. 2003
    ..We conclude that CaR regulation of PTHrP release in H-500 cells involves activation of PKC as well as the ERK1/2, p38 MAPK, and JNK pathways...
  6. ncbi Calcium-sensing receptor activation induces intracellular calcium oscillations
    G E Breitwieser
    Department of Physiology, Johns Hopkins University School of Medicine, 725 N Wolfe St, Baltimore, MD 21205, USA
    Am J Physiol Cell Physiol 280:C1412-21. 2001
    ..Serum Ca2+ concentrations thus chronically regulate cells expressing CaR, and small perturbations in extracellular Ca2+ alter both resting intracellular Ca2+ as well as Ca2+ dynamics...
  7. ncbi Autosomal dominant hypocalcaemia caused by a Ca(2+)-sensing receptor gene mutation
    M R Pollak
    Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115
    Nat Genet 8:303-7. 1994
    ..We conclude that this extracellular domain mutation increases the receptor's activity at low Ca2+ concentrations, causing hypocalcaemia in patients heterozygous for such a mutation...
  8. ncbi Diseases associated with the extracellular calcium-sensing receptor
    R V Thakker
    Nuffield Department of Clinical Medicine, Botnar Research Centre, Nuffield Orthopaedic Centre, University of Oxford, Headington, Oxford OX3 7LD, UK
    Cell Calcium 35:275-82. 2004
    ..e. autoimmune) of hypoparathyroidism. Thus, abnormalities of the CaSR are associated with three hypercalcaemic and three hypocalcaemic disorders...
  9. ncbi Extracellular calcium and calcium sensing receptor function in human colon carcinomas: promotion of E-cadherin expression and suppression of beta-catenin/TCF activation
    Subhas Chakrabarty
    Department of Molecular Pathology, University of Texas, M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Res 63:67-71. 2003
    ..In addition, the promotion of E-cadherin and suppression of beta-catenin/T cell factor may be an important mechanism underlying the chemopreventive action of Ca(2+) in colon cancer...
  10. ncbi Calcium sensing receptor in human colon carcinoma: interaction with Ca(2+) and 1,25-dihydroxyvitamin D(3)
    Subhas Chakrabarty
    Department of Molecular Pathology, University of Texas, MD Anderson Cancer Center, Houston, TX 77030, USA
    Cancer Res 65:493-8. 2005
    ....
  11. ncbi Association between activating mutations of calcium-sensing receptor and Bartter's syndrome
    Sumiyo Watanabe
    Department of Internal Medicine, University of Tokyo School of Medicine, Tokyo, Japan
    Lancet 360:692-4. 2002
    ..We therefore suggest that some activating mutations of CASR could provide new mechanisms for the development of Bartter's syndrome...
  12. pmc Extracellular calcium sensing receptor in human pancreatic cells
    G Z Racz
    Institute of Experimental Medicine, Hungarian Academy of Sciences, H 1083 Budapest, Hungary
    Gut 51:705-11. 2002
    ..However, the CaR has also been identified in other tissues where its role is less clear. We have investigated the presence of the CaR in the human pancreas...
  13. ncbi Calcium-sensing receptor induces proliferation through p38 mitogen-activated protein kinase and phosphatidylinositol 3-kinase but not extracellularly regulated kinase in a model of humoral hypercalcemia of malignancy
    J Tfelt-Hansen
    Division of Endocrinology, Diabetes and Hypertension, Department of Medicine and Membrane Biology Program, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Endocrinology 145:1211-7. 2004
    ..These effects are likely direct without the involvement of PTHrP in an autocrine mode...
  14. ncbi R990G polymorphism of calcium-sensing receptor does produce a gain-of-function and predispose to primary hypercalciuria
    G Vezzoli
    Nephrology and Dialysis Unit, Postgraduate School of Nephrology, Vita Salute University, IRCCS San Raffaele Hospital, Milan, Italy
    Kidney Int 71:1155-62. 2007
    ..0001). Our findings indicate that R990G polymorphism results in a gain-of-function of the calcium-sensing receptor and increased susceptibility to primary hypercalciuria...
  15. ncbi A986S polymorphism of the calcium-sensing receptor and circulating calcium concentrations
    D E Cole
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Ontario, Canada
    Lancet 353:112-5. 1999
    ..The CASR missense polymorphism, A986S, is common in the general population and is, therefore, a prime candidate as a genetic determinant of extracellular calcium concentration...
  16. pmc Identification and dissection of Ca(2+)-binding sites in the extracellular domain of Ca(2+)-sensing receptor
    Yun Huang
    Department of Chemistry, Center for Biotechnology and Drug Design Georgia State University, Atlanta, Georgia 30303, USA
    J Biol Chem 282:19000-10. 2007
    ....
  17. ncbi Structure and function of the human calcium-sensing receptor: insights from natural and engineered mutations and allosteric modulators
    Jianxin Hu
    Molecular Signalling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Cell Mol Med 11:908-22. 2007
    ....
  18. ncbi Cooperative multi-modal sensing and therapeutic implications of the extracellular Ca(2+) sensing receptor
    A D Conigrave
    Department of Biochemistry G08, University of Sydney, NSW 2006, Australia
    Trends Pharmacol Sci 21:401-7. 2000
    ..Furthermore, new work indicates that the CaR is subject to allosteric activation by L-amino acids...
  19. ncbi Blood ionized calcium is associated with clustered polymorphisms in the carboxyl-terminal tail of the calcium-sensing receptor
    Alfredo Scillitani
    Unit of Endocrinology, Hospital Casa Sollievo della Sofferenza, Istituto di Ricovero e Cura a Carattere Scientifico, Viale dei Cappuccini, 71013 San Giovanni Rotondo FG, Italy
    J Clin Endocrinol Metab 89:5634-8. 2004
    ..Given the significant between-population variations in frequency of variant alleles in this CASR SNP cluster, tri-locus haplotyping may prove to be more informative in studies of association between variation in CASR and disease...
  20. ncbi Alanine to serine polymorphism at position 986 of the calcium-sensing receptor associated with coronary heart disease, myocardial infarction, all-cause, and cardiovascular mortality
    Winfried März
    Synlab Center of Laboratory Diagnostics Heidelberg, Heidelberg, Germany
    J Clin Endocrinol Metab 92:2363-9. 2007
    ..An alanine (A) to serine (S) polymorphism at codon 986 (A986S) of the CASR gene has been associated with higher calcium and osteoporosis; the association with coronary artery disease (CAD) has not been studied...
  21. ncbi The extracellular calcium-sensing receptor and cell-cell signaling in epithelia
    Aldebaran M Hofer
    Department of Surgery, Harvard Medical School, Brigham and Women s Hospital and Boston VA Healthcare System, 1400 VFW Parkway, West Roxbury, MA 02132, USA
    Cell Calcium 35:297-306. 2004
    ..Such a mechanism could potentially provide CaR-expressing cells with the means to sense the Ca2+ signaling status of their neighbors, and expand the utility of the intracellular Ca2+ signal to a domain outside the cell...
  22. ncbi Molecular cloning and functional expression of human parathyroid calcium receptor cDNAs
    J E Garrett
    Department of Molecular Biology, NPS Pharmaceuticals, Salt Lake City, Utah 84108, USA
    J Biol Chem 270:12919-25. 1995
    ..While there is no evidence for alteration of the primary amino acid sequence of the CaR in this adenoma, modulation of CaR biosynthesis through alternative RNA processing may play a role in set-point alterations...
  23. pmc Regulation of murine fetal-placental calcium metabolism by the calcium-sensing receptor
    C S Kovacs
    Endocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Invest 101:2812-20. 1998
    ..Disruption of the CaSR causes fetal hyperparathyroidism and hypercalcemia, with additional effects on placental calcium transfer...
  24. ncbi Calcimimetic and calcilytic drugs: just for parathyroid cells?
    E F Nemeth
    NPS Pharmaceuticals, Inc, 30 College Street, Suite 301, Toronto, Ont, Canada
    Cell Calcium 35:283-9. 2004
    ....
  25. pmc Intermolecular interactions between dimeric calcium-sensing receptor monomers are important for its normal function
    M Bai
    Endocrine Hypertension Division, Department of Medicine, Brigham and Women s Hospital, and Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 96:2834-9. 1999
    ..Our study suggests that intermolecular interactions within the dimeric CaR are important for the receptor's function...
  26. ncbi The extracellular calcium Ca2+o-sensing receptor is expressed in myeloma cells and modulates cell proliferation
    Toru Yamaguchi
    Department of Internal Medicine, Takatsuki General Hospital, 1 3 13 Kosobe cho, Takatsuki 569 1192, Japan
    Biochem Biophys Res Commun 299:532-8. 2002
    ..These processes may result in promoting further growth of the tumor and aggravating the associated bone disease...
  27. ncbi Dimerization of the extracellular calcium-sensing receptor (CaR) on the cell surface of CaR-transfected HEK293 cells
    M Bai
    Endocrine Hypertension Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 273:23605-10. 1998
    ..Taken together, we conclude from these results that the functional CaR resides on the cell surface of transfected HEK293 cells in the form of a dimer...
  28. ncbi The calcium-sensing receptor: a key factor in the pathogenesis of secondary hyperparathyroidism
    Mariano Rodriguez
    Unidad de Investigacion, Servicio de Nefrologia, Hospital Universitario Reina Sofia, Avd Menendez Pidal s n, 14004 Cordoba, Spain
    Am J Physiol Renal Physiol 288:F253-64. 2005
    ..Effective new treatments for SHPT that have a positive impact on mineral metabolism are clearly needed. Recent research shows that drugs that selectively target the CaR, calcimimetics, have the potential to meet these requirements...
  29. ncbi Association between total serum calcium and the A986S polymorphism of the calcium-sensing receptor gene
    D E Cole
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada
    Mol Genet Metab 72:168-74. 2001
    ..These data are the first to show significant association between a common polymorphism and concentrations of a serum electrolyte. The A986S polymorphism is also a potential predisposing factor in disorders of bone and mineral metabolism...
  30. ncbi The calcium-sensing receptor is a target of autoantibodies in patients with autoimmune polyendocrine syndrome type 1
    Nikos G Gavalas
    Section of Endocrinology and Reproduction, School of Medicine and Biomedical Sciences, University of Sheffield, Royal Hallamshire Hospital, Glossop Road, Sheffield, UK
    J Clin Endocrinol Metab 92:2107-14. 2007
    ..However, the detection of CaSR antibodies in APS1 remains controversial, with some studies disputing the relevance of the receptor as an autoantigen...
  31. ncbi Another dimension to calcium signaling: a look at extracellular calcium
    Aldebaran M Hofer
    VA Boston Healthcare System and Brigham and Women s Hospital, Department of Surgery, Harvard Medical School, 1400 VFW Parkway, West Roxbury, MA 02132, USA
    J Cell Sci 118:855-62. 2005
    ..The extracellular space might therefore constitute a much more dynamic Ca(2+) signaling compartment than previously appreciated...
  32. ncbi Three adjacent serines in the extracellular domains of the CaR are required for L-amino acid-mediated potentiation of receptor function
    Zaixiang Zhang
    Department of Medicine, Endocrine Hypertension Division, Brigham and Women s Hospital and Harvard Medical School, 221 Longwood Avenue, Boston, MA 02115, USA
    J Biol Chem 277:33727-35. 2002
    ....
  33. ncbi Mechanisms of secondary hyperparathyroidism
    Justin Silver
    Minerva Center for Calcium and Bone Metabolism, Nephrology and Hypertension Services, Hadassah University Hospital, Jerusalem, Israel 91120
    Am J Physiol Renal Physiol 283:F367-76. 2002
    ..PT trans factors and cis elements have been defined...
  34. ncbi Functional characterization of a calcium-sensing receptor mutation in severe autosomal dominant hypocalcemia with a Bartter-like syndrome
    Rosa Vargas-Poussou
    INSERM U423, Department of Physiology, Universite Rene Descartes, Hopital Necker Enfants Malades, Paris, France
    J Am Soc Nephrol 13:2259-66. 2002
    ....
  35. ncbi Parathyroid-specific double knockout of Gq and G11 alpha-subunits leads to a phenotype resembling germline knockout of the extracellular Ca2+ -sensing receptor
    Nina Wettschureck
    Pharmakologisches Institut der Universität Heidelberg, Im Neuenheimer Feld 366, 69120 Heidelberg, Germany
    Mol Endocrinol 21:274-80. 2007
    ..Our results demonstrate the critical role of both Gq and G11 in mediating inhibition of PTH secretion by extracellular Ca2+...
  36. ncbi Calcium-sensing receptor gene polymorphism Arg990Gly and its possible effect on response to cinacalcet HCl
    Hansjörg M Rothe
    Division of Nephrology and Hypertension, The Brookdale University Hospital and Medical Center, Brooklyn, New York 11212, USA
    Pharmacogenet Genomics 15:29-34. 2005
    ....
  37. ncbi Comparison of hypocalcemic hypercalciuria between patients with idiopathic hypoparathyroidism and those with gain-of-function mutations in the calcium-sensing receptor: is it possible to differentiate the two disorders?
    M Yamamoto
    Third Department of Internal Medicine, National Defense Medical College, Saitama, Japan
    J Clin Endocrinol Metab 85:4583-91. 2000
    ....
  38. ncbi Type B gamma-aminobutyric acid receptors modulate the function of the extracellular Ca2+-sensing receptor and cell differentiation in murine growth plate chondrocytes
    Zhiqiang Cheng
    Endocrine Research Unit, Department of Veterans Affairs Medical Center, 4150 Clement Street, San Francisco, CA 94121, USA
    Endocrinology 148:4984-92. 2007
    ..These results support the idea that physical interactions between CaRs and GABA-B-R1s modulate the growth and differentiation of GPCs, potentially by altering the function of CaRs...
  39. ncbi The extracellular calcium-sensing receptor reciprocally regulates the secretion of BMP-2 and the BMP antagonist Noggin in colonic myofibroblasts
    Dinithi Peiris
    Gastrointestinal Diseases Research Unit, Kingston General Hospital, and Department of Physiology, Queen s University, Kingston, Ontario, Canada
    Am J Physiol Gastrointest Liver Physiol 292:G753-66. 2007
    ..Together, our data suggest that the CaSR mediates the effective concentration of BMP-2 in the intestine, which leads to enhanced repair and barrier development...
  40. ncbi Pharmacological and clinical properties of calcimimetics: calcium receptor activators that afford an innovative approach to controlling hyperparathyroidism
    Nobuo Nagano
    Pharmaceutical Development Laboratories, Kirin Brewery Company, Limited, Takasaki, Gunma, Japan
    Pharmacol Ther 109:339-65. 2006
    ..Indeed, cinacalcet has already been approved for marketing in several countries. Calcimimetic compounds like cinacalcet have great potential as an innovative medical approach to manage 1HPT and 2HPT...
  41. pmc Calcium sensing receptor: molecular cloning in rat and localization to nerve terminals
    M Ruat
    Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 92:3161-5. 1995
    ..Cerebral arteries display an intense network of CaSR immunoreactive fibers associated with vessel innervation. CaSR on nerve terminal membranes may regulate neurotransmitter disposition in response to Ca2+ levels in the synaptic space...
  42. ncbi Extracellular calcium-sensing receptor: structural and functional features and association with diseases
    O M Hauache
    Laboratório de Endocrinologia Molecular, Disciplina de Endocrinologia, Departamento de Medicina, Escola Paulista de Medicina, Universidade Federal de Sao Paulo, Sao Paulo, SP, Brasil
    Braz J Med Biol Res 34:577-84. 2001
    ....
  43. ncbi The extracellular calcium-sensing receptor (CaSR) on human esophagus and evidence of expression of the CaSR on the esophageal epithelial cell line (HET-1A)
    Christopher J Justinich
    Department of Pediatrics, Queen s University, Kingston, Ontario, Canada
    Am J Physiol Gastrointest Liver Physiol 294:G120-9. 2008
    ..We conclude that the CaSR is present on basal cells of the human esophagus and is present in a functional manner on the esophageal epithelial cell line, HET-1A...
  44. ncbi Prevalence of calcium sensing receptor autoantibodies in patients with sporadic idiopathic hypoparathyroidism
    Ravinder Goswami
    Department of Endocrinology and Metabolism, All India Institute of Medical Sciences, New Delhi 110029, India
    Eur J Endocrinol 150:9-18. 2004
    ....
  45. pmc Calcium-sensing receptor activation depresses synaptic transmission
    Cecilia G Phillips
    Division of Pulmonary and Critical Care Medicine, Oregon Health and Science University, Portland, Oregon 97239, USA
    J Neurosci 28:12062-70. 2008
    ..In summary, reduced CaSR function enhanced synaptic transmission and CaSR stimulation had the opposite effect. Thus CaSR provides a mechanism that may compensate for the fall in release probability that accompanies decreases in [Ca](o)...
  46. pmc The calcium-sensing receptor is required for normal calcium homeostasis independent of parathyroid hormone
    Claudine H Kos
    Renal Division, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Clin Invest 111:1021-8. 2003
    ..Thus, CaR is necessary for the fine regulation of serum calcium levels and renal calcium excretion independent of its effect on PTH secretion...
  47. ncbi Familial benign hypocalciuric hypercalcemia
    Ghada El Hajj Fuleihan
    Calcium Metabolism and Osteoporosis Program, American University of Beirut Medical Center, Lebanon
    J Bone Miner Res 17:N51-6. 2002
    ..In general, in view of the benign nature of FBHH, no particular intervention is needed except reassurance and counseling against parathyroidectomy...
  48. ncbi The Venus Fly Trap domain of the extracellular Ca2+ -sensing receptor is required for L-amino acid sensing
    Hee Chang Mun
    School of Molecular and Microbial Biosciences, University of Sydney, NSW 2006, Australia
    J Biol Chem 279:51739-44. 2004
    ..The findings support the concept that the mGlu-1 amino acid binding site for L-glutamate is conserved as an L-amino acid binding site in its homolog, the CaR...
  49. ncbi Calcium and polyamine regulated calcium-sensing receptors in cardiac tissues
    Rui Wang
    Department of Physiology, University of Saskatchewan, Saskatoon, SK, Canada
    Eur J Biochem 270:2680-8. 2003
    ..Our results demonstrated that Ca-SR was expressed in cardiac tissue and cardiomyocytes and its function was regulated by extracellular calcium and spermine...
  50. ncbi Extracellular calcium (Ca2+(o))-sensing receptor in a murine bone marrow-derived stromal cell line (ST2): potential mediator of the actions of Ca2+(o) on the function of ST2 cells
    T Yamaguchi
    Department of Medicine, Brigham and Women s Hospital, and Harvard Medical School, Boston, Massachusetts 02115, USA
    Endocrinology 139:3561-8. 1998
    ....
  51. ncbi Wnt5a secretion stimulated by the extracellular calcium-sensing receptor inhibits defective Wnt signaling in colon cancer cells
    R John Macleod
    Department of Physiology, Queen s University, 76 Stuart Street, Kingston, Ontario, Canada
    Am J Physiol Gastrointest Liver Physiol 293:G403-11. 2007
    ..Our findings demonstrate that APC status plays a key role as a determinant of Wnt5a secretion and suggest that CaSR-mediated secretion of Wnt5a will inhibit defective Wnt signaling in APC-truncated cells in an autocrine manner...
  52. pmc Rescue of the skeletal phenotype in CasR-deficient mice by transfer onto the Gcm2 null background
    Qisheng Tu
    Center for Bone and Mineral Disorders, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Clin Invest 111:1029-37. 2003
    ..Double Gcm2- and CasR-deficient mice provide an important model for evaluating the extraparathyroid functions of CasR...
  53. pmc Genetic testing in familial isolated hyperparathyroidism: unexpected results and their implications
    J Warner
    Department of Diabetes and Endocrinology, Princess Alexandra Hospital, Ipswich Rd, Woolloongabba 4102, QLD, Australia
    J Med Genet 41:155-60. 2004
    ..Also apparent is the need for further investigation to identify additional genes associated with FIHP...
  54. ncbi Homology modeling of the transmembrane domain of the human calcium sensing receptor and localization of an allosteric binding site
    Susanne U Miedlich
    Department of Biology, Syracuse University, Syracuse, New York 13244, USA
    J Biol Chem 279:7254-63. 2004
    ....
  55. ncbi Calcium-sensing receptor autoantibodies are relevant markers of acquired hypoparathyroidism
    Anne Mayer
    Unité Fonctionnelle d Auto Immunité, Centre Hospitalier Lyon Sud, 69495 Pierre Benite Cedex, France
    J Clin Endocrinol Metab 89:4484-8. 2004
    ..In conclusion, using an immunoblotting assay, we demonstrate the presence of CaSR aAbs in about one third of the patients with isolated AH, pointing out the value of detecting such aAbs to assess the autoimmune origin of the disease...
  56. ncbi Aminoglycosides induce acute cell signaling and chronic cell death in renal cells that express the calcium-sensing receptor
    Donald T Ward
    Faculty of Life Sciences, The University of Manchester, Oxford Road, Manchester, M13 9PT United Kingdom
    J Am Soc Nephrol 16:1236-44. 2005
    ....
  57. ncbi Recordings from single neocortical nerve terminals reveal a nonselective cation channel activated by decreases in extracellular calcium
    Stephen M Smith
    Department of Molecular and Cellular Physiology, Stanford University School of Medicine, CA 94305, USA
    Neuron 41:243-56. 2004
    ..Activation of NSC channels by falls in [Ca(2+)](o) would be expected during periods of high activity in the neocortex and may modulate the excitability of the presynaptic terminal...
  58. ncbi Identification of three novel mutations in the GATA3 gene responsible for familial hypoparathyroidism and deafness in the Chinese population
    Wei Yih Chiu
    Department of Laboratory Medicine, National Taiwan University Hospital, No 7, Chung Shan South Road, Taipei 100, Taiwan
    J Clin Endocrinol Metab 91:4587-92. 2006
    ..Familial hypoparathyroidism may be caused by mutations of several genes. The CaSR and GATA3 genes are the two candidates most commonly responsible for this condition...
  59. pmc An acquired hypocalciuric hypercalcemia autoantibody induces allosteric transition among active human Ca-sensing receptor conformations
    Noriko Makita
    Department of Endocrinology and Nephrology, University of Tokyo School of Medicine 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Proc Natl Acad Sci U S A 104:5443-8. 2007
    ..We thus speculate that physiological modulators may exist that enable an agonist to specifically activate only one signaling pathway via a GPCR that activates multiple signaling pathways...
  60. ncbi Clinical lessons from the calcium-sensing receptor
    Edward M Brown
    Division of Endocrinology, Diabetes and Hypertension at Brigham and Women s Hospital in Boston, MA, USA
    Nat Clin Pract Endocrinol Metab 3:122-33. 2007
    ..Finally, calcimimetics-allosteric activators of the CaR-treat secondary hyperparathyroidism effectively in end-stage renal failure...
  61. ncbi Calcium receptor-mediated intracellular signalling
    Donald T Ward
    School of Biological Sciences, University of Manchester, G38 Stopford Building, Oxford Road, Manchester M13 9PT, UK
    Cell Calcium 35:217-28. 2004
    ..This review will detail the intracellular pathways by which the CaR is believed to elicit its physiological functions and summarises the evidence for cell- and agonist-specific differential signalling...
  62. ncbi Functional effects of monoclonal antibodies to the purified amino-terminal extracellular domain of the human Ca(2+) receptor
    Jianxin Hu
    Molecular Pathophysiology Section, NIDCD, National Institutes of Health, Bethesda, MD 20892, USA
    J Bone Miner Res 22:601-8. 2007
    ..Flow cytometry studies of chimeric receptors localized their epitopes to lobe 2 of the VFT domain. These results lead us to propose a mechanism for the functional effects of these antibodies...
  63. ncbi Genetics of endocrine and metabolic disorders: parathyroid
    R V Thakker
    May Professor of Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Botnar Research Centre, Nuffield Orthopaedic Centre, Headington, Oxford OX3 7LD, UK
    Rev Endocr Metab Disord 5:37-51. 2004
  64. ncbi A syndrome of hypocalciuric hypercalcemia caused by autoantibodies directed at the calcium-sensing receptor
    Olga Kifor
    Harvard Medical School, Boston, Massachusetts 02115, USA
    J Clin Endocrinol Metab 88:60-72. 2003
    ..Autoimmune hypocalciuric hypercalcemic is an acquired disorder of Ca(2+)(o) sensing that should be differentiated from that caused by inactivating mutations of the CaR...
  65. ncbi CASRdb: calcium-sensing receptor locus-specific database for mutations causing familial (benign) hypocalciuric hypercalcemia, neonatal severe hyperparathyroidism, and autosomal dominant hypocalcemia
    Svetlana Pidasheva
    Department of Medicine, McGill University, and Calcium Research Laboratory, Royal Victoria Hospital, Montreal, Quebec, Canada
    Hum Mutat 24:107-11. 2004
    ..The CASRdb will help researchers to better understand and analyze the mutations, and aid in structure-function analyses...
  66. ncbi Parathyroid cells cultured in collagen matrix retain calcium responsiveness: importance of three-dimensional tissue architecture
    Cynthia S Ritter
    Renal Division, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Bone Miner Res 19:491-8. 2004
    ..These findings also illustrate the importance of 3-D cellular architecture in parathyroid gland function...
  67. ncbi Activating antibodies to the calcium-sensing receptor in two patients with autoimmune hypoparathyroidism
    Olga Kifor
    Division of Endocrinology, Diabetes and Hypertension, Brigham and Women s Hospital, and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Clin Endocrinol Metab 89:548-56. 2004
    ....
  68. ncbi Naturally occurring mutations of the extracellular Ca2+-sensing receptor: implications for its structure and function
    Jianxin Hu
    Molecular Pathophysiology Section, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD 20892, USA
    Trends Endocrinol Metab 14:282-8. 2003
    ....
  69. ncbi Involvement of calcium-sensing receptor in ischemia/reperfusion-induced apoptosis in rat cardiomyocytes
    Wei hua Zhang
    Department of Pathophysiology, Harbin Medical University, Harbin 150086, China
    Biochem Biophys Res Commun 347:872-81. 2006
    ..In conclusion, these results suggest that CaR is involved in the induction of cardiomyocyte apoptosis during ischemia/reperfusion through activation of cytochrome c-caspase-3 signaling pathway...
  70. ncbi Renal physiology of the extracellular calcium-sensing receptor
    Donald T Ward
    School of Biological Sciences, University of Manchester, G38 Stopford Building, Oxford Road, Manchester M13 9PT, UK
    Pflugers Arch 445:169-76. 2002
    ..The renal expression of CaR will be detailed in this review and its role in integrating [Ca2+]o with the calciotropic signals responsible for Ca2+ homeostasis will be discussed...
  71. ncbi Calcium receptor is functionally expressed in rat neonatal ventricular cardiomyocytes
    Jacob Tfelt-Hansen
    Laboratory of Molecular Cardiology, Department of Cardiology, Copenhagen University Hospital, Rigshospitaket, Denmark
    Am J Physiol Heart Circ Physiol 290:H1165-71. 2006
    ..A specific calcium-sensing receptor on cardiac myocytes could play a role in regulating cardiac development, function, and homeostasis...
  72. ncbi Regulation of MAP kinase by calcium-sensing receptor in bovine parathyroid and CaR-transfected HEK293 cells
    O Kifor
    Endocrine-Hypertension Division and Membrane Biology Program, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA
    Am J Physiol Renal Physiol 280:F291-302. 2001
    ....
  73. ncbi Activation of calcium-sensing receptor accelerates apoptosis in hyperplastic parathyroid cells
    Masahide Mizobuchi
    Department of Nephrology, School of Medicine, Showa University, Tokyo, Japan
    Biochem Biophys Res Commun 362:11-6. 2007
    ..These results suggest that CaR activation by R-568 accelerates parathyroid cell death, probably through an apoptotic mechanism in uremic rats in vitro...
  74. ncbi Complex formation with the Type B gamma-aminobutyric acid receptor affects the expression and signal transduction of the extracellular calcium-sensing receptor. Studies with HEK-293 cells and neurons
    Wenhan Chang
    Endocrine Research Unit, Department of Veterans Affairs Medical Center, Department of Medicine, University of California, San Francisco, California 94121, USA
    J Biol Chem 282:25030-40. 2007
    ....
  75. ncbi Systemic activation of the calcium sensing receptor produces acute effects on vascular tone and circulatory function in uremic and normal rats: focus on central versus peripheral control of vascular tone and blood pressure by cinacalcet
    Ryan M Fryer
    Integrative Pharmacology, Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064 6119, USA
    J Pharmacol Exp Ther 323:217-26. 2007
    ..Moreover, subsequent mechanistic studies suggest that increases in MAP produced by cinacalcet may be mediated by reduced tonic NO synthase-dependent NO production subsequent to reductions in blood iCa2+...
  76. pmc L-amino acid sensing by the extracellular Ca2+-sensing receptor
    A D Conigrave
    Endocrine Hypertension Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 97:4814-9. 2000
    ..The actions of l-amino acids on the CaR may provide explanations for several long recognized but poorly understood actions of dietary protein on calcium metabolism...
  77. pmc Regulation of calcium-sensing-receptor trafficking and cell-surface expression by GPCRs and RAMPs
    Tristan Bouschet
    Department of Anatomy, Medical Research Council Centre for Synaptic Plasticity, School of Medical Sciences, University of Bristol, University Walk, Bristol, UK
    Trends Pharmacol Sci 29:633-9. 2008
    ....
  78. ncbi The calcium sensing receptor and its alternatively spliced form in murine epidermal differentiation
    Y Oda
    Department of Medicine and Dermatology, University of California San Francisco, Veterans Affairs Medical Center, San Francisco, California 94121, USA
    J Biol Chem 275:1183-90. 2000
    ..These results indicate that CaR is important in epidermal differentiation, and that the alternatively spliced form does not fully compensate for loss of the full-length CaR...
  79. ncbi Delineating a Ca2+ binding pocket within the venus flytrap module of the human calcium-sensing receptor
    Caroline Silve
    INSERM, U426, Faculté deMédecine Xavier Bichat and IFR02, Paris, France
    J Biol Chem 280:37917-23. 2005
    ..Altogether, these data define a Ca(2+) binding pocket within the CaSR VFTM that may be conserved in several other class III GPCRs, thereby providing a molecular basis for extracellular Ca(2+) sensing by these receptors...
  80. pmc Calcimimetics with potent and selective activity on the parathyroid calcium receptor
    E F Nemeth
    NPS Pharmaceuticals, Inc, 420 Chipeta Way, Salt Lake City, UT 84108, USA
    Proc Natl Acad Sci U S A 95:4040-5. 1998
    ..Calcimimetic compounds could conceivably provide a specific medical therapy for primary hyperparathyroidism...
  81. pmc Does vitamin D receptor and calcium receptor activation therapy play a role in the histopathologic alterations of parathyroid glands in refractory uremic hyperparathyroidism?
    Carlo Lomonte
    Division of Nephrology, Miulli General Hospital, Acquaviva delle Fonti, Manduria, Italy
    Clin J Am Soc Nephrol 3:794-9. 2008
    ..This study was aimed to assess a possible association between histopathologic changes of parathyroid tissue and treatment modality...
  82. ncbi Protein kinase C phosphorylation of threonine at position 888 in Ca2+o-sensing receptor (CaR) inhibits coupling to Ca2+ store release
    M Bai
    Endocrine Hypertension Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 273:21267-75. 1998
    ..Our results suggest that phosphorylation of the CaR is the molecular basis for the previously described effect of PKC activation on Ca2+o-evoked changes in Ca2+i dynamics in parathyroid cells...
  83. ncbi Mutations in the Ca(2+)-sensing receptor gene cause autosomal dominant and sporadic hypoparathyroidism
    J Baron
    Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 1862, USA
    Hum Mol Genet 5:601-6. 1996
    ..This augmented hypercalciuria increases the risk of renal complications and thus has implications for the choice of therapy...
  84. ncbi Interaction of the calcium-sensing receptor and filamin, a potential scaffolding protein
    H Awata
    Division of Nephrology, Department of Medicine, Case Western Reserve University, Louis Stokes Veteran Affairs Medical Center, Cleveland, Ohio 44106, USA
    J Biol Chem 276:34871-9. 2001
    ....
  85. ncbi Direct in vitro evidence of the suppressive effect of cinacalcet HCl on parathyroid hormone secretion in human parathyroid cells with pathologically reduced calcium-sensing receptor levels
    Takehisa Kawata
    Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, 1 4 3Asahi machi, Abeno Ku, Osaka, 545 8585, Japan
    J Bone Miner Metab 24:300-6. 2006
    ..Data from this in vitro analysis support the clinical application of cinacalcet in PHPT and SHPT therapy...
  86. ncbi Cardiac microvascular endothelial cells express a functional Ca+ -sensing receptor
    Roberto Berra Romani
    Department of Biomedicine, School of Medicine, Benemerita Universidad Autonoma de Puebla, Puebla, Mexico
    J Vasc Res 46:73-82. 2009
    ..These data provide evidence that CMEC express CaSR, which is able to respond to physiological agonists by mobilizing Ca(2+) from intracellular InsP(3)-sensitive stores...
  87. ncbi Influence of calcium-sensing receptor gene on urinary calcium excretion in stone-forming patients
    Giuseppe Vezzoli
    Division of Nephrology Dialysis and Hypertension, Postgraduate School of Nephrology, Ateneo Vita e Salute, IRCCS San Raffaele Hospital, Milan, Italy
    J Am Soc Nephrol 13:2517-23. 2002
    ..Arg990Gly polymorphism could facilitate activation of CaSR and increase Ca excretion and susceptibility to idiopathic hypercalciuria...
  88. pmc Polyvalent cation receptor proteins (CaRs) are salinity sensors in fish
    J Nearing
    MariCal, Portland, ME 04101, USA
    Proc Natl Acad Sci U S A 99:9231-6. 2002
    ..We conclude that CaRs act as salinity sensors in both teleost and elasmobranch fish. Their tissue expression patterns in fish provide insights into CaR functions in terrestrial animals including humans...
  89. ncbi Expression and characterization of inactivating and activating mutations in the human Ca2+o-sensing receptor
    M Bai
    Endocrine Hypertension Division, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Biol Chem 271:19537-45. 1996
    ..Conversely, one activating mutation, which causes a form of autosomal dominant hypocalcemia, appears to increase the affinity of the receptor for its agonists...
  90. ncbi Activating mutations of the calcium-sensing receptor: management of hypocalcemia
    A Lienhardt
    Service de Pediatrie, Centre Hospitalier Universitaire, 87042 Limoges, France
    J Clin Endocrinol Metab 86:5313-23. 2001
    ..Treatment options should be weighed carefully in patients with serum Ca below 1.95 mmol/liter. The risk of nephrocalcinosis during treatment can be minimized by carefully monitoring urinary Ca excretion...
  91. ncbi Can calcimimetics inhibit parathyroid hyperplasia? Evidence from preclinical studies
    Tilman Drueke
    Nephrol Dial Transplant 22:1828-39. 2007
  92. ncbi Association of polymorphic alleles of the calcium-sensing receptor gene with the clinical severity of primary hyperparathyroidism
    M Yamauchi
    Third Division, Department of Medicine, Kobe University School of Medicine, Chuo Ku, Kobe, Japan
    Clin Endocrinol (Oxf) 55:373-9. 2001
    ..In this study, we examined the relationship between CaR polymorphisms and biochemical markers in pHPT patients...
  93. ncbi Frequency of the calcium-sensing receptor variant A986S in patients with primary hyperparathyroidism
    S Miedlich
    III. Medical Department, University of Leipzig, Leipzig, Germany
    Eur J Endocrinol 145:421-7. 2001
    ..The previously reported significant correlation of serum calcium levels with the genetic variant A986S in healthy subjects could not be confirmed...
  94. ncbi High calcium activates the EGF receptor potentially through the calcium-sensing receptor in Leydig cancer cells
    Jacob Tfelt-Hansen
    Division of Endocrinology, Diabetes and Hypertension, Department of Medicine and Membrane Biology Program, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Growth Factors 23:117-23. 2005
    ..In conclusion, the calcium activates the EGFR, possibly through the CaR, to regulate downstream signaling events and important biological functions in a model of HHM...
  95. ncbi Biochemical and cellular effects of direct maxacalcitol injection into parathyroid gland in uremic rats
    Kazuhiro Shiizaki
    Center of Blood Purification Therapy, Wakayama Medical University, 811 1 Kimiidera, Wakayama 641 0012, Japan
    J Am Soc Nephrol 16:97-108. 2005
    ..DI-OCT may introduce simultaneous VDR and CaSR upregulations and the regression of hyperplastic PTG, and these effects may provide a strategy for strongly suppressing PTH levels in very severe secondary hyperparathyroidism...
  96. ncbi Calcimimetics--fooling the calcium receptor
    Eberhard Ritz
    Pediatr Nephrol 20:15-8. 2005
    ..In secondary hyperparathyroidism, a specific advantage is the concomitant lowering of serum calcium and phosphate concentrations...
  97. ncbi [Clinical application of calcimimetics]
    Hiroshi Nishi
    Division of Nephrology and Dialysis Center, Kobe University School of Medicine
    Clin Calcium 14:756-9. 2004
    ....
  98. ncbi [Calcimimetics, mechanisms of action and therapeutic applications]
    P Urena
    Service de Néphrologie Dialyse, Clinique de l Orangerie, Aubervilliers 93
    Presse Med 34:1095-100. 2005
    ....
  99. ncbi [Cell proliferation of parathyroid gland in patients with progressive secondary hyperparathyroidism: Vitamin D receptor, calcium sensing receptor, and cell cycle regulation factor]
    Masanori Tokumoto
    Clin Calcium 15:206-16. 2005
  100. ncbi [Secondary hyperparathyroidism]
    Shohei Nakanishi
    Division of Nephrology and Dialysis Center, Kobe University School of Medicine
    Nihon Rinsho 63:341-6. 2005
  101. ncbi Calcimimetics and hyperparathyroidism
    Linda J Krebs
    Center for Molecular Medicine, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030 3101, USA
    Curr Opin Investig Drugs 5:1080-5. 2004
    ....

Research Grants62

  1. Conditional Knockout of Calcium Receptors in Bone Cells
    Dolores M Shoback; Fiscal Year: 2013
    ....
  2. Blood Pressure Regulation: Novel Roles for the Kidney
    Pablo A Ortiz; Fiscal Year: 2013
    ..Thus it will accelerate acquisition of knowledge of the novel mechanisms by which the kidney regulates blood pressure, and may provide new targets for anti-hypertensive drugs. ..
  3. Calcium-sensing Receptor and Keratinocyte Differentiation
    Chia Ling Tu; Fiscal Year: 2013
    ..Successful completion of this project will greatly advance our knowledge of skin cell differentiation and help understanding the pathogenesis of various skin disorders manifesting abnormal differentiation. ..
  4. Novel Ca receptor signaling pathways for control of renal ion transport
    Richard Tyler Miller; Fiscal Year: 2012
    ..This information will result in recognition of a new way to control the amount of salt in the body and hopefully new ways to treat high and low blood pressure. ..
  5. Calcium Sensing Receptor Signaling in the Gastrointestinal Tract
    Osvaldo Rey; Fiscal Year: 2009
    ..We also anticipate that these mechanistic studies will be extended to normal colon epithelial cells and thus provide a robust base for the formulation of an R01 award application. ..
  6. Calcium-Sensing Receptors and Growth Plate Development
    Wenhan Chang; Fiscal Year: 2012
    ..This proposal will investigate how Ca2+ acts on these chondrocytes and will help us understand how to treat disorders of growth and poor mineralization like rickets. ..
  7. Mechanism of Desensitization of Perivascular Nerve Ca2+-sensing Receptor Signalin
    EMMANUEL MODESTO AWUMEY; Fiscal Year: 2013
    ..In addition, the proposed studies will provide training opportunities for under-represented minority students at NCCU and prepare them for future careers in biomedical research. ..
  8. The Role of CaSR and GABA-B-R in Neuronal Responses to Ischemic Brain Injury
    Wenhan Chang; Fiscal Year: 2013
    ..The successful completion of the study will establish a novel pathway that produces ischemia-induced neuronal injury and will develop a new therapy for treating diseases due to ischemic brain injury. ..
  9. Ca2+ Signaling in Pulmonary Arterial Hypertension: Role of CaSR and TRPC6
    Jason X J Yuan; Fiscal Year: 2013
    ....
  10. A novel cannabinoid receptor in cortical nerve terminals
    Stephen M Smith; Fiscal Year: 2011
    ..By studying this new pathway we will discover more about how cannabis works and so improve the chances of designing new treatments to help stop cannabis use. ..
  11. Calcium regulation of spontaneous release of GABA
    Courtney L Williams; Fiscal Year: 2013
    ..Understanding the mechanism by which Ca2+ influences release of neurotransmitter will contribute to an improved understanding of synaptic function in general and when transmission is disrupted in disease states. ..
  12. Central calcium and cannabinoid signaling
    Stephen M Smith; Fiscal Year: 2013
    ..Moreover, distinguishing the various actions of cannabinoids may translate into the identification of a novel class of drugs that facilitate treatment of cannabis addiction and several neurological diseases. ..
  13. Sun Valley Workshop on Skeletal Biology
    David Burr; Fiscal Year: 2004
    ..An Advisory Panel is formed of session chairs. There are plans to advertise and distribute a summary of the workshop, partly using Web-based resources. ..
  14. EFFECT OF AGING ON CALCIUM BLOCKER KINETICS/DYNAMICS
    JANICE SCHWARTZ; Fiscal Year: 1993
    ..Potential age-related changes in beta-adrenergic and calcium receptors within the AV node will be studied with quantitative autoradiography of the rat AV node...
  15. DESENSITIZATION AND DOWN REGULATION OF CALCIUM RECEPTORS
    Dolores Shoback; Fiscal Year: 2002
    ..Our studies should provide insights into mechanisms underlying CaR responsiveness in secretion and growth. ..
  16. Vitamin D & Calcium Regulation Biomarkers in Colon Cancer Risk Reduction
    Roberd Bostick; Fiscal Year: 2007
    ..Two intriguing mechanistic hypotheses concern vitamin D autocrine/paracrine activity and tissue-specific calcium sensing receptors (CaSR)...
  17. CA2+ SENSING RECEPTOR EXPRESSION IN HYPERPARATHYROIDISM
    Alex Brown; Fiscal Year: 2002
    ..abstract_text> ..
  18. ANABOLIC ACTIONS OF Ca2+-RECEPTOR IN OSTEOBLASTIC CELLS
    Naibedya Chattopadhyay; Fiscal Year: 2005
    ....
  19. Signaling Complexes in Renal Epithelial Cells
    Richard Miller; Fiscal Year: 2005
    ..abstract_text> ..
  20. EXTRACELLULAR CALCIUM-SENSING RECEPTORS IN OSTEOBLASTS
    L Quarles; Fiscal Year: 2009
    ..Successful completion of this project is certain to yield important new knowledge regarding the function of GPRC6A. ..
  21. Mechanisms Linking Ca2+ Homeostasis & Vascular Tone
    Faye Calhoun; Fiscal Year: 2007
    ....
  22. CALCIUM SENSING RECEPTOR REGULATION OF SECRETION
    Ruben Diaz; Fiscal Year: 2001
    ..My long term plan is to develop a research program devoted to the identification and characterization of molecular components involved in membrane traffic effected by CaR-regulated second messengers in parathyroid and other cells. ..
  23. CALCIUM RECEPTORS AND PROLIFERATIVE SIGNALS
    Karin Rodland; Fiscal Year: 2001
    ..These aims will be accomplished through experiments using specific inhibitors and dominant negative mutants of the key participants in the hypothesized signaling pathway ..
  24. Ca Signaling Pathways and Receptors in Bipolar Disorder
    Peter Vassilev; Fiscal Year: 2005
    ..In the long term, the application of CaR potentiators and their synergistic actions with other antipsychotic drugs could help introducing novel therapeutic strategies. ..
  25. DIURNAL AND PULSATILE PTH SECRETION IN RENAL FAILURE
    William Goodman; Fiscal Year: 2001
    ....
  26. Coronary calcification in hemodialysis patients
    William Goodman; Fiscal Year: 2005
    ....
  27. A MICROSURGICAL INVESTIGATION OF GASTRIC ACID SECRETION
    John Geibel; Fiscal Year: 2004
    ..abstract_text> ..
  28. REGULATION OF THE NA+ COUPLED CL- COTRANSPORTERS
    Steven Hebert; Fiscal Year: 2004
    ..This has important relevance to understanding salt and water handling by the kidney in health and disease. ..
  29. INHIBITION OF PTH SECRETION: CaR AND THE CYTOSKELETON
    Edward M Brown; Fiscal Year: 2007
    ..Phosphorylation of caveolin-1 under high Ca 2+ conditions may anchor the CaR-PTH unit to the plasma membrane, limiting PTH secretion. ..
  30. CA2+-RECEPTOR: IMMUNE MODULATION IN VIVO AND IN VITRO
    Edward M Brown; Fiscal Year: 2007
    ..3) To develop an animal model of activating and/or inactivating antibodies by immunization with the CaR's extracellular domain. [unreadable] [unreadable]..
  31. PHARMACOLOGY OF BOVINE PARATHYROID CA++ RECEPTORS
    Edward M Brown; Fiscal Year: 2002
    ....
  32. Resolution of Stage-Specific Growth Plate Chondrocytes
    Wenhan Chang; Fiscal Year: 2004
    ..The effects of PTHrP on cyclic AMP (cAMP) formation, phospholipase C (PLC) activity, and intracellular Ca 2. mobilization will be examined in different subpopulations of chondrocytes. ..
  33. Mitochondrial Genetics of Recovery After Brain Injury
    Yvette Conley; Fiscal Year: 2008
    ....
  34. Molecular Mechanisms of Ectopic Bone Formation
    STEVEN LIETMAN; Fiscal Year: 2006
    ..abstract_text> ..
  35. INTERACTIONS BETWEEN GABA B AND CA2+-SENSING RECEPTORS
    Wenhan Chang; Fiscal Year: 2008
    ..This work can open up future studies targeted to developing therapies to modulate the function of CaRs, GABA-B-Rs, or the heteromeric complexes of these two receptors. [unreadable] [unreadable] [unreadable]..
  36. THE EFFECT OF APOE ON OUTCOMES IN TBI ADULTS
    Yvette Conley; Fiscal Year: 2003
    ....
  37. CALCIUM RECEPTOR SIGNAL RECOGNITION AND TRANSDUCTION
    Edward M Brown; Fiscal Year: 2006
    ..abstract_text> ..
  38. The Genetic Basis of a Disease Free Model of Aging
    Yvette Conley; Fiscal Year: 2006
    ..This is the first study to propose to use lens transparency as a continuous, quantitative measure of the human aging process that will be suitable for genetic linkage and gene identification. ..
  39. CA2+ RECEPTOR, PTHRP & MALIGNANCY-INDUCED OSTEOLYSIS
    Edward M Brown; Fiscal Year: 2004
    ..abstract_text> ..
  40. SPATIAL AND TEMPORAL REGULATION OF PROTEIN KINASE D
    Osvaldo Rey; Fiscal Year: 2007
    ..Our hypothesis is that the kinase activity of PKC regulates PKD by coordinating its catalytic activation and intracellular localization. [unreadable] [unreadable]..
  41. ATP2A2-Regulated Keratinocyte Ca2+ Signaling Mechanisms
    Theodora M Mauro; Fiscal Year: 2010
    ..The goal of this project is to define the pathogenic signaling pathways that lead to abnormal differentiation in Darier's disease, thus ameliorating the skin pathology of patients suffering from this condition. ..
  42. Calcium sensing receptor and scaffolds
    GERDA BREITWIESER; Fiscal Year: 2009
    ..Understand the role of scaffolds in CaR function may provide novel, specific sites for pharmacological intervention in treatment of calcium handling diseases. ..
  43. EFFECTS OF ACID ON BONE
    David A Bushinsky; Fiscal Year: 2010
    ..The current proposal is aimed at understanding the first steps by which acid is detected by bone cells. Understanding the process by which the bone detects and neutralizes the acid can lead to an improvement in bone health. ..
  44. NIH OSTEOPOROSIS & RELATED BONE DISEASES RESOURCE CENTER
    Bess Dawson Hughes; Fiscal Year: 2002
    ..Specific efforts include supporting the National Osteoporosis Data Group, collecting and disseminating definitive statistics on bone diseases and on conditions co-morbid with osteoporosis, and preparing summary reports. ..
  45. PTHrP on normal osteoblast differentiation and function
    RAMIRO TORIBIO; Fiscal Year: 2008
    ..Dr. Thomas Rosol's laboratory will provide an excellent environment for developing the skills necessary to become a successful independent researcher. ..
  46. Molecular mechanism of G protein coupling to the melanocortin-3 receptor
    Ya Xiong Tao; Fiscal Year: 2008
    ..Current pharmacotherapies are far from ideal in terms of both efficacy and side effect. Our long-term goal is to exploit the melanocortin system as a novel approach for obesity treatment. [unreadable] [unreadable] [unreadable]..
  47. THE PHYSIOLOGY AND METABOLISM OF VITAMIN D
    Rajiv Kumar; Fiscal Year: 2003
    ..Results of this investigation could lead to a better understanding of the pathogenesis of bone diseases and the formulation of new therapeutic strategies in disorders such as hyperparathyroidism and osteoporosis. ..
  48. DIFERENTIAL ACTIVATION OF THE VITAMIN D RECEPTOR
    Sara Peleg; Fiscal Year: 2003
    ..These studies will facilitate the development of selective vitamin D receptor modulators that may be useful for treatment of various clinical conditions, including osteoporosis, secondary hyperparathyroidism, and cancer. ..
  49. MYCOBACTERIAL RESISTANCE TO REACTIVE NITROGEN/OXYGEN
    Carl Nathan; Fiscal Year: 2003
    ....
  50. Low-Renin Hypertension in African Americans
    John Pratt; Fiscal Year: 2003
    ..In summary, we explore unique but simple approaches to treatment of low-renin hypertension in blacks, a treatment modality that could prove useful to many patients currently with uncontrolled blood pressure. ..
  51. ROLE OF NO SYNTHASE-2 IN MURINE ALZHEIMER'S DISEASE
    Carl Nathan; Fiscal Year: 2004
    ..abstract_text> ..
  52. Polarized Targeting of Metabotropic Glutamate Receptors
    Anna Francesconi; Fiscal Year: 2004
    ..This application is ideally suited to the R21 format in that it employs high-risk experiments based on new technologies that may lead to major advances in this field. ..
  53. CALCIUM RECEPTOR IN MAMMARY DEVELOPMENT AND PHYSIOLOGY
    Joshua VanHouten; Fiscal Year: 2006
    ..This will be accomplished through formal course work and by interactions with the co-sponsor and collaborators. Yale is an ideal training environment, with an abundance of physical and intellectual resources. ..
  54. Small Laboratory Animal Imaging: High Resolution Microcomputed Tomography System
    RAMIRO TORIBIO; Fiscal Year: 2006
    ..Salary and benefits for the Supervisor and Space and utilities for the instrument will be provided by Department of Veterinary Biosciences and the College of Veterinary Medicine. [unreadable] [unreadable]..
  55. Fiber and Colorectal Adenomas: A Pooling Project
    Elizabeth Jacobs; Fiscal Year: 2005
    ..If it is found that certain groups may receive greater benefit from fiber, then public health recommendations can be made which target these groups and prevent the recurrence of colorectal adenomas. ..
  56. Genetic Determinants of Sodium Retention
    John Pratt; Fiscal Year: 2006
    ..In summary, by exploring candidate sites for increased Na retention in blacks in comparison to whites, we seek to identify new mechanisms for common forms of hypertension. ..
  57. Cardiac Outcomes Associated with Renal Osteodystrophy
    Bryan Kestenbaum; Fiscal Year: 2007
    ..The proposed study aims to shed light on the relationship between a common renal related metabolic disorder and the epidemic burden of CVD found among this patient population. ..
  58. Biology of a Novel Phosphaturic Protein - sFRP-4
    Rajiv Kumar; Fiscal Year: 2007
    ..Our findings will have important implications with respect to Pi homeostasis, bone mineralization in mammals and humans, and the regulation of ion transport through Wnt signaling in the kidney. ..
  59. EXPRESSION AND STRUCTURE OF THE CALCIUM SENSING RECEPTOR
    Rajiv Kumar; Fiscal Year: 2007
    ..Furthermore, this information will serve as the basis for more extensive experiments involving the structure of the full-length receptor. [unreadable] [unreadable]..
  60. EFFECT OF POTASSIUM BICARBONATE ON BONE AND MUSCLE
    Bess Dawson Hughes; Fiscal Year: 2008
    ....
  61. CA++ RECEPTOR--FUNCTIONAL INTERACTIONS WITH OTHER GPCRS
    Mei Bai; Fiscal Year: 2002
    ....