calcitonin gene related peptide receptors

Summary

Summary: Cell surface proteins that bind calcitonin gene-related peptide (CGRP) with high affinity and trigger intracellular changes which influence the behavior of cells. CGRP receptors are present in both the central nervous system and the periphery and are not the same as calcitonin receptors.

Top Publications

  1. ncbi CGRP receptors: a headache to study, but will antagonists prove therapeutic in migraine?
    Susan D Brain
    Centre for Cardiovascular Biology and Medicine, New Hunt s House, King s College, Guy s Campus, SE1 1UL, London, UK
    Trends Pharmacol Sci 23:51-3. 2002
  2. ncbi RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor
    L M McLatchie
    Receptor Systems and Cell Biology Units, Glaxo Wellcome Medicines Research Centre, Stevenage, Hertfordshire, UK
    Nature 393:333-9. 1998
  3. ncbi The role of calcitonin gene-related peptide (CGRP) in the generation and maintenance of mechanical allodynia and hyperalgesia in rats after intradermal injection of capsaicin
    Rui Qing Sun
    Department of Anatomy and Neuroscience, Marine Biomedical Institute, The University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555 1069, USA
    Pain 104:201-8. 2003
  4. ncbi Agonist-promoted internalization of a ternary complex between calcitonin receptor-like receptor, receptor activity-modifying protein 1 (RAMP1), and beta-arrestin
    S Hilairet
    Departement de Biochimie, Universite de Montreal, Montreal, Quebec, H3C 3J7, Canada
    J Biol Chem 276:42182-90. 2001
  5. ncbi Functional calcitonin gene-related peptide receptors are formed by the asymmetric assembly of a calcitonin receptor-like receptor homo-oligomer and a monomer of receptor activity-modifying protein-1
    Madeleine Heroux
    Department of Biochemistry and Groupe de Recherche Universitaire sur le Médicament, Universite de Montreal, Montreal, Quebec H3C 3J7, Canada
    J Biol Chem 282:31610-20. 2007
  6. ncbi Pharmacological characterization of MK-0974 [N-[(3R,6S)-6-(2,3-difluorophenyl)-2-oxo-1-(2,2,2-trifluoroethyl)azepan-3-yl]-4-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxamide], a potent and orally active calcitonin gene-related pept
    Christopher A Salvatore
    Merck Research Laboratories, WP26A 2000, West Point, PA 19486, USA
    J Pharmacol Exp Ther 324:416-21. 2008
  7. ncbi Role of calcitonin gene-related peptide in the sensitization of dorsal horn neurons to mechanical stimulation after intradermal injection of capsaicin
    Rui Qing Sun
    Department of Neuroscience and Cell Biology, The University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555 1069, USA
    J Neurophysiol 92:320-6. 2004
  8. pmc Treatment of migraine attacks based on the interaction with the trigemino-cerebrovascular system
    Andrea Stephanie Link
    Biomedical Center Lund, Lund, Sweden
    J Headache Pain 9:5-12. 2008
  9. ncbi Efficacy and tolerability of MK-0974 (telcagepant), a new oral antagonist of calcitonin gene-related peptide receptor, compared with zolmitriptan for acute migraine: a randomised, placebo-controlled, parallel-treatment trial
    Tony W Ho
    Merck Research Laboratories, North Wales, PA 19454 1099, USA
    Lancet 372:2115-23. 2008
  10. ncbi Presence and function of the calcitonin gene-related peptide receptor on rat pial arteries investigated in vitro and in vivo
    K A Petersen
    Danish Headache Center, University of Copenhagen, Denmark
    Cephalalgia 25:424-32. 2005

Detail Information

Publications209 found, 100 shown here

  1. ncbi CGRP receptors: a headache to study, but will antagonists prove therapeutic in migraine?
    Susan D Brain
    Centre for Cardiovascular Biology and Medicine, New Hunt s House, King s College, Guy s Campus, SE1 1UL, London, UK
    Trends Pharmacol Sci 23:51-3. 2002
  2. ncbi RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor
    L M McLatchie
    Receptor Systems and Cell Biology Units, Glaxo Wellcome Medicines Research Centre, Stevenage, Hertfordshire, UK
    Nature 393:333-9. 1998
    ..RAMP1 presents the receptor at the cell surface as a mature glycoprotein and a CGRP receptor. RAMP2-transported receptors are core-glycosylated and are adrenomedullin receptors...
  3. ncbi The role of calcitonin gene-related peptide (CGRP) in the generation and maintenance of mechanical allodynia and hyperalgesia in rats after intradermal injection of capsaicin
    Rui Qing Sun
    Department of Anatomy and Neuroscience, Marine Biomedical Institute, The University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555 1069, USA
    Pain 104:201-8. 2003
    ..Collectively, these results suggest that CGRP receptors present in the dorsal horn are involved in the generation and maintenance of nociceptive behaviors associated with cutaneous inflammation...
  4. ncbi Agonist-promoted internalization of a ternary complex between calcitonin receptor-like receptor, receptor activity-modifying protein 1 (RAMP1), and beta-arrestin
    S Hilairet
    Departement de Biochimie, Universite de Montreal, Montreal, Quebec, H3C 3J7, Canada
    J Biol Chem 276:42182-90. 2001
    ..These results therefore indicate that although atypical by its heterodimeric composition and its targeting to the plasma membrane, the CGRP receptor shares endocytotic mechanisms that are common to most classical 7TM receptors...
  5. ncbi Functional calcitonin gene-related peptide receptors are formed by the asymmetric assembly of a calcitonin receptor-like receptor homo-oligomer and a monomer of receptor activity-modifying protein-1
    Madeleine Heroux
    Department of Biochemistry and Groupe de Recherche Universitaire sur le Médicament, Universite de Montreal, Montreal, Quebec H3C 3J7, Canada
    J Biol Chem 282:31610-20. 2007
    ....
  6. ncbi Pharmacological characterization of MK-0974 [N-[(3R,6S)-6-(2,3-difluorophenyl)-2-oxo-1-(2,2,2-trifluoroethyl)azepan-3-yl]-4-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxamide], a potent and orally active calcitonin gene-related pept
    Christopher A Salvatore
    Merck Research Laboratories, WP26A 2000, West Point, PA 19486, USA
    J Pharmacol Exp Ther 324:416-21. 2008
    ..In conclusion, MK-0974 is a highly potent, selective, and orally bioavailable CGRP receptor antagonist, which may be valuable in the acute treatment of migraine...
  7. ncbi Role of calcitonin gene-related peptide in the sensitization of dorsal horn neurons to mechanical stimulation after intradermal injection of capsaicin
    Rui Qing Sun
    Department of Neuroscience and Cell Biology, The University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555 1069, USA
    J Neurophysiol 92:320-6. 2004
    ..The effect could be blocked by CGRP(8-37) dose-dependently. Collectively, these results suggest that CGRP and its receptors are involved in the spinal cord central sensitization induced by intradermal injection of capsaicin...
  8. pmc Treatment of migraine attacks based on the interaction with the trigemino-cerebrovascular system
    Andrea Stephanie Link
    Biomedical Center Lund, Lund, Sweden
    J Headache Pain 9:5-12. 2008
    ..The purpose of this review is to give a short overview of the pathological background of migraine headache and to illustrate the mechanisms behind the actions of triptans and the promising CGRP receptor blockers...
  9. ncbi Efficacy and tolerability of MK-0974 (telcagepant), a new oral antagonist of calcitonin gene-related peptide receptor, compared with zolmitriptan for acute migraine: a randomised, placebo-controlled, parallel-treatment trial
    Tony W Ho
    Merck Research Laboratories, North Wales, PA 19454 1099, USA
    Lancet 372:2115-23. 2008
    ..We aimed to assess the clinical profile of MK-0974 (telcagepant), an orally bioavailable antagonist of CGRP receptor...
  10. ncbi Presence and function of the calcitonin gene-related peptide receptor on rat pial arteries investigated in vitro and in vivo
    K A Petersen
    Danish Headache Center, University of Copenhagen, Denmark
    Cephalalgia 25:424-32. 2005
    ..8 +/- 3.3 mmHg and 49.2 +/- 3.3 mmHg. Our results suggest that CGRP receptors are probably functional on the smooth muscle cells and not on the endothelium of rat cerebral arteries...
  11. ncbi Calcitonin gene-related peptide receptor antagonist BIBN 4096 BS for the acute treatment of migraine
    Jes Olesen
    Department of Neurology, Glostrup Hospital, University of Copenhagen, Copenhagen, Denmark
    N Engl J Med 350:1104-10. 2004
    ..Calcitonin gene-related peptide (CGRP) may have a causative role in migraine. We therefore hypothesized that a CGRP-receptor antagonist might be effective in the treatment of migraine attacks...
  12. ncbi CGRP-RCP, a novel protein required for signal transduction at calcitonin gene-related peptide and adrenomedullin receptors
    B N Evans
    Departments of Physiology and Biophysics, Biochemistry and Molecular Biology, and Neuroscience Program, University of Miami School of Medicine, Miami, Florida 33101, USA
    J Biol Chem 275:31438-43. 2000
    ....
  13. ncbi BIBN4096BS antagonizes human alpha-calcitonin gene related peptide-induced headache and extracerebral artery dilatation
    Kenneth A Petersen
    Danish Headache Center, University of Copenhagen and Department of Neurology, Glostrup University Hospital, KAS Glostrup, DK 2600 Glostrup, Denmark
    Clin Pharmacol Ther 77:202-13. 2005
    ..We investigated the ability of BIBN4096BS to inhibit human alphaCGRP (h-alphaCGRP)-induced headache and cerebral hemodynamic changes in healthy volunteers...
  14. ncbi Calcitonin gene-related peptide receptor activation produces PKA- and PKC-dependent mechanical hyperalgesia and central sensitization
    Rui Qing Sun
    Department of Neuroscience and Cell Biology, The University of Texas Medical Branch, 301 University Blvd, Galveston, Texas 77555 1069, USA
    J Neurophysiol 92:2859-66. 2004
    ....
  15. ncbi Randomized controlled trial of an oral CGRP receptor antagonist, MK-0974, in acute treatment of migraine
    T W Ho
    Merck Research Laboratories, UG 4C 18, PO Box 1000, North Wales, PA 19454 1099, USA
    Neurology 70:1304-12. 2008
    ..To determine an effective and tolerable dose of a novel oral calcitonin gene-related peptide (CGRP) receptor antagonist, MK-0974, for the acute treatment of migraine...
  16. ncbi Functional and biophysical analysis of the C-terminus of the CGRP-receptor; a family B GPCR
    Matthew Conner
    School of Biosciences, University of Birmingham, UK
    Biochemistry 47:8434-44. 2008
    ..This helix structure appears to be found in most other family B GPCRs...
  17. ncbi Blockade of CGRP receptors in the intracranial vasculature: a new target in the treatment of headache
    L Edvinsson
    Department of Internal Medicine, Lund University Hospital, Lund, Sweden
    Cephalalgia 24:611-22. 2004
    ..The initial pharmacological profile of such a group of compounds has recently been disclosed. One of these compounds has been found to be efficacious in the relief of acute attacks of migraine...
  18. pmc Pharmacological profile of BIBN4096BS, the first selective small molecule CGRP antagonist
    H Doods
    Boehringer Ingelheim Pharma KG, Biberach, Germany
    Br J Pharmacol 129:420-3. 2000
    ..v.) inhibited the effects of CGRP, released by stimulation of the trigeminal ganglion, on facial blood flow in marmoset monkeys. It is concluded that BIBN4096BS is a potent and selective CGRP antagonist...
  19. ncbi Calcitonin gene-related peptide 8-37 inhibits the evoked discharge frequency of wide dynamic range neurons in dorsal horn of the spinal cord in rats
    L C Yu
    Department of Physiology, College of Life Science, Peking University, Beijing, People s Republic of China
    Regul Pept 83:21-4. 1999
    ..The results indicate that CGRP receptors play an important role in the transmission of presumed nociceptive information in the dorsal horn of the spinal cord...
  20. ncbi Calcitonin gene-related peptide antagonists as treatments of migraine and other primary headaches
    Peter J Goadsby
    Headache Group, Institute of Neurology and The National Hospital for Neurology and Neurosurgery, London, UK
    Drugs 65:2557-67. 2005
    ..The prospect of a non-vasoconstricting therapy for acute migraine offers a real opportunity to patients, and perhaps more importantly, provides a therapeutic rationale to reinforce migraine as a neurological disorder...
  21. pmc Inhibitory effect of BIBN4096BS, CGRP(8-37), a CGRP antibody and an RNA-Spiegelmer on CGRP induced vasodilatation in the perfused and non-perfused rat middle cerebral artery
    L Edvinsson
    Department of Medicine, Institute of Clinical Sciences, University Hospital, Lund, Sweden
    Br J Pharmacol 150:633-40. 2007
    ..We have compared these CGRP scavengers with two known receptor antagonists (CGRP8-37 and BIBN4096BS) on CGRP-induced relaxations in the rat middle cerebral artery (MCA). Furthermore, the role of the endothelial barrier has been studied...
  22. ncbi Critical role of calcitonin gene-related peptide 1 receptors in the amygdala in synaptic plasticity and pain behavior
    Jeong S Han
    Department of Neuroscience and Cell Biology, The University of Texas Medical Branch, Galveston, Texas 77555 1069, USA
    J Neurosci 25:10717-28. 2005
    ..This study provides direct evidence for the critical dependence of pain behavior on CGRP1-mediated amygdala plasticity...
  23. ncbi Development of human calcitonin gene-related peptide (CGRP) receptor antagonists. 1. Potent and selective small molecule CGRP antagonists. 1-[N2-[3,5-dibromo-N-[[4-(3,4-dihydro-2(1H)-oxoquinazolin-3-yl)-1-piperidinyl]carbonyl]-D-tyrosyl]-l-lysyl]-4-(4-pyr
    Klaus Rudolf
    Boehringer Ingelheim Pharma GmbH and Co KG, Research Division, Birkendorfer Strasse 65, 88397 Biberach Riss, Germany
    J Med Chem 48:5921-31. 2005
    ..This finding strongly supports our initial working hypothesis that CGRP plays an important role in the pathophysiology of migraine...
  24. ncbi Structure-function analysis of RAMP1 by alanine mutagenesis
    John Simms
    School of Life and Health Sciences, Aston University, Birmingham B4 7ET, UK
    Biochemistry 48:198-205. 2009
    ..The data are consistent with a CLR recognition site particularly involving Y66 and H97, with lesser roles for adjacent residues in helix 3. L69 and T73 may contribute to a CGRP recognition site in helix 2 also involving nearby residues...
  25. ncbi RAMPs: accessory proteins for seven transmembrane domain receptors
    S M Foord
    Receptor Systems, Molecular Pharmacology Unit, GlaxoWellcome Medicines Research Centre, Gunnels Wood Road, Stevenage, UK SG1 2NY
    Trends Pharmacol Sci 20:184-7. 1999
  26. ncbi Potent, orally bioavailable calcitonin gene-related peptide receptor antagonists for the treatment of migraine: discovery of N-[(3R,6S)-6-(2,3-difluorophenyl)-2-oxo-1- (2,2,2-trifluoroethyl)azepan-3-yl]-4- (2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin- 1-yl
    Daniel V Paone
    Department of Medicinal Chemistry, Merck Research Laboratories, P O Box 4, West Point, Pennsylvania 19486, USA
    J Med Chem 50:5564-7. 2007
    ....
  27. ncbi Safety, tolerability and pharmacokinetics of BIBN 4096 BS, the first selective small molecule calcitonin gene-related peptide receptor antagonist, following single intravenous administration in healthy volunteers
    M Iovino
    Human Pharmacology Centre, Department of Clinical Research, Boehringer Ingleheim Pharma GmbH and Co KG, Ingelheim, Germany
    Cephalalgia 24:645-56. 2004
    ..The mean renal clearance (CLR) was approximately 2 l/h, suggesting that renal excretion plays only a minor role in the elimination of unchanged BIBN 4096 BS...
  28. ncbi Sensitization of calcitonin gene-related peptide receptors by receptor activity-modifying protein-1 in the trigeminal ganglion
    Zhongming Zhang
    Department of Molecular Physiology and Biophysics, University of Iowa, Iowa City, Iowa 52242, USA
    J Neurosci 27:2693-703. 2007
    ..These results demonstrate that RAMP1 is functionally rate limiting for CGRP receptor activity in the trigeminal ganglion, which raises the possibility that elevated RAMP1 might sensitize some individuals to CGRP actions in migraine...
  29. pmc Calcitonin gene-related peptide (CGRP) modulates nociceptive trigeminovascular transmission in the cat
    Robin James Storer
    Headache Group, Institute of Neurology, Queen Square, London WCIN SBG
    Br J Pharmacol 142:1171-81. 2004
    ....
  30. ncbi In-depth characterization of CGRP receptors in human intracranial arteries
    Inger Jansen-Olesen
    Department of Neurology, Glostrup Hospital, Nordre Ringvej 57 Dk 2600 Glostrup, Denmark
    Eur J Pharmacol 481:207-16. 2003
    ..In conclusion, our molecular and pharmacological data support the existence of a single type of CGRP(1) receptors in the human intracranial circulation...
  31. ncbi Immunohistochemical localization of calcitonin receptor-like receptor and receptor activity-modifying proteins in the human cerebral vasculature
    Kevin R Oliver
    The Neuroscience Research Center, Merck, Sharp and Dohme Research Laboratories, Terling s Park, Harlow, Essex CM20 2QR, United Kingdom
    J Cereb Blood Flow Metab 22:620-9. 2002
    ....
  32. ncbi Effect of the CGRP receptor antagonist BIBN4096BS in human cerebral, coronary and omental arteries and in SK-N-MC cells
    Lars Edvinsson
    Department of Internal Medicine, Lund University Hospital, 22185 Lund, Sweden
    Eur J Pharmacol 434:49-53. 2002
    ..BIBN4096 had a pA(2) value of 10.1 in cerebral and 10.4 in coronary arteries. The results of clinical trials with BIBN4096BS for acute migraine attacks are awaited with great interest...
  33. ncbi Identification and pharmacological characterization of domains involved in binding of CGRP receptor antagonists to the calcitonin-like receptor
    Christopher A Salvatore
    Pain Research Department, Merck Research Laboratories, West Point, Pennsylvania 19486, USA
    Biochemistry 45:1881-7. 2006
    ..Collectively, these data provide insight into two alternative mechanisms of antagonism for this unique heterodimeric receptor complex...
  34. ncbi Mutations of the asparagine117 residue of a receptor activity-modifying protein 1-dependent human calcitonin gene-related peptide receptor result in selective loss of function
    R Gujer
    Research Laboratory for Calcium Metabolism, Departments of Orthopedic Surgery and Medicine, University of Zurich, Klinik Balgrist, 8008 Zurich, Switzerland
    Biochemistry 40:5392-8. 2001
    ..Unlike Asn(60) and Asn(112), Asn(117) is normally not N-glycosylated, but essential for CGRP binding to the hCRLR-RAMP1 complex...
  35. ncbi Characterisation of CGRP receptors in the human isolated middle meningeal artery
    Saurabh Gupta
    Department of Pharmacology, Erasmus MC, University Medical Center Rotterdam, P O Box 1738, 3000 DR Rotterdam, The Netherlands
    Life Sci 79:265-71. 2006
    ..This view is reinforced by Schild plot analysis, which revealed a slope of unity in all experiments, giving further evidence for a homogeneous CGRP receptor population in this vascular preparation...
  36. ncbi Positive inotropy mediated via CGRP receptors in isolated human myocardial trabeculae
    O Saetrum Opgaard
    Department of Pharmacology, Erasmus University, 3000 DR, Rotterdam, Netherlands
    Eur J Pharmacol 397:373-82. 2000
    ..mRNAs for calcitonin receptor-like receptor and specific RAMPs further support the presence of CGRP receptors...
  37. ncbi Investigation of the species selectivity of a nonpeptide CGRP receptor antagonist using a novel pharmacodynamic assay
    James C Hershey
    Department of Cardiovascular Diseases, Merck Research Laboratories, West Point, PA 19486, USA
    Regul Pept 127:71-7. 2005
    ..In conclusion, this is the first report to describe and validate a noninvasive model in nonhuman primates that allows rapid evaluation of CGRP antagonist activity against endogenous CGRP...
  38. pmc Calcitonin gene-related peptide enhances release of native brain-derived neurotrophic factor from trigeminal ganglion neurons
    Ilya Buldyrev
    Department of Integrative Biosciences, Oregon Health and Science University, Portland, Oregon 97239, USA
    J Neurochem 99:1338-50. 2006
    ..Together, these results reveal a previously unknown role for CGRP in regulating BDNF availability, and point to BDNF as a candidate mediator of trigeminal nociceptive plasticity...
  39. ncbi Immature osteoblastic MG63 cells possess two calcitonin gene-related peptide receptor subtypes that respond differently to [Cys(Acm)(2,7)] calcitonin gene-related peptide and CGRP(8-37)
    Tomoyuki Kawase
    Division of Cellular Pharmacology, Department of Signal Transduction Research, Graduate School of Medical and Dental Sciences, Niigata University, 2 5274 Gakkocho dori, Niigata 951 8514, Japan
    Am J Physiol Cell Physiol 289:C811-8. 2005
    ....
  40. ncbi Mechanisms of the vasorelaxant effect of Danshen (Salvia miltiorrhiza) in rat knee joints
    F Y Lam
    Department of Pharmacology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, China
    J Ethnopharmacol 104:336-44. 2006
    ..However, there is no evidence to support a role for muscarinic receptors, adrenoceptors, or histamine receptors...
  41. ncbi Intermedin is a calcitonin/calcitonin gene-related peptide family peptide acting through the calcitonin receptor-like receptor/receptor activity-modifying protein receptor complexes
    Jaesook Roh
    Division of Reproductive Biology, Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, California 94305 5317, USA
    J Biol Chem 279:7264-74. 2004
    ....
  42. ncbi Involvement of calcitonin gene-related peptide and capsaicin-sensitive afferents in central thyrotropin-releasing hormone-induced hepatic cytoprotection
    Masashi Yoneda
    Department of Gastroenterology, Dokkyo University School of Medicine, Kitakobayashi 880, Mibu, Tochigi 321 0293, Japan
    Eur J Pharmacol 478:173-7. 2003
    ..These data demonstrate the involvement of capsaicin-sensitive afferent neurons and CGRP in central TRH-induced hepatic cytoprotection...
  43. ncbi New evidence on the mechanisms underlying bradykinin-mediated contraction of the pig iris sphincter in vitro
    Mariem El Sayah
    Department of Pharmacology, Centre of Biological Sciences, Universidade Federal de Santa Catarina, Rua Ferreira Lima 82, Florianopolis, SC 88015 420, Brazil
    Peptides 24:1045-51. 2003
    ..Finally, these responses are mediated by activation of both protein kinase A- and C-dependent mechanisms...
  44. ncbi Peripheral adrenomedullin inhibits gastric emptying through CGRP8-37 -sensitive receptors and prostaglandins pathways in rats
    V Martinez
    CURE Digestive Diseases Research Center, Department of Medicine, David Geffen School of Medicine at UCLA, University of California Los Angeles and VA Greater Los Angeles Healthcare System, Los Angeles, CA 90073, USA
    Peptides 27:1376-82. 2006
    ..These data indicate that peripheral AM inhibits gastric emptying through the interaction with CGRP8-37 -sensitive receptors, likely CGRP1 receptors, and the recruitment of prostaglandin-dependent mechanisms...
  45. ncbi Mechanisms involved in calcitonin gene-related Peptide-induced relaxation in pregnant rat uterine artery
    P R R Gangula
    Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, Texas 77555, USA
    Biol Reprod 69:1635-41. 2003
    ..These studies suggest that CGRP-induced increases in uterine artery relaxation may play a role in regulating blood flow to the uterus during pregnancy and, therefore, in fetal growth and survival...
  46. ncbi Neurogenic components of trypsin- and thrombin-induced inflammation in rat skin, in vivo
    Otilia Obreja
    Department of Anaesthesiology and Intensive Care, Faculty of Clinical Medicine Mannheim, University of Medicine Heidelberg, Mannheim, Germany
    Exp Dermatol 15:58-65. 2006
    ..Thrombin-induced PE and VD are mediated mainly by a non-neurogenic mechanism...
  47. ncbi Enhanced vascular responses to adrenomedullin in mice overexpressing receptor-activity-modifying protein 2
    C W Tam
    Cardiovascular Division, King s College London, United Kingdom
    Circ Res 98:262-70. 2006
    ..Thus RAMP2 plays a key role in the sensitivity and potency of AM-induced hypotensive responses via the AM1 receptor, providing evidence that this receptor is a selective target for novel therapeutic approaches...
  48. ncbi Expression of calcitonin gene-related peptide receptor components, calcitonin receptor-like receptor and receptor activity modifying protein 1, in the rat placenta during pregnancy and their cellular localization
    Y L Dong
    Department of Obstetrics and Gynecology, 301 University Blvd, Medical Research Building, Rm 11 138, The University of Texas Medical Branch, Galveston, TX 77555 1062, USA
    Mol Hum Reprod 9:481-90. 2003
    ..Elevated placental CRLR and RAMP(1) may be involved in CGRP-related increases in blood flow and therefore fetal growth and decreases at term labour may help minimize the blood loss...
  49. ncbi Female sex steroid hormones and pregnancy regulate receptors for calcitonin gene-related peptide in rat mesenteric arteries, but not in aorta
    C Yallampalli
    Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, Texas 77555 1062, USA
    Biol Reprod 70:1055-62. 2004
    ....
  50. ncbi Identification, structural determination, and biological activity of bovine and canine calcitonin receptor-stimulating peptides
    Takeshi Katafuchi
    National Cardiovascular Center Research Institute, 5 7 1 Fujishirodai, Suita, Osaka 565 8565, Japan
    Biochem Biophys Res Commun 313:74-9. 2004
    ....
  51. ncbi Pharmacological characterization of novel alpha-Calcitonin Gene-Related Peptide (CGRP) receptor peptide antagonists that are selective for human CGRP receptors
    Christopher K Taylor
    Creighton University School of Medicine, Department of Pharmacology, 2500 California Plaza, Omaha, NE 68178, USA
    J Pharmacol Exp Ther 319:749-57. 2006
    ..Thus, these analogs may be useful compounds for development of drugs to treat migraine headache and other cardiovascular diseases...
  52. ncbi Calcitonin gene-related peptide and substance P regulate the intestinal radiation response
    Junru Wang
    Arkansas Cancer Research Center, Little Rock, Arkansas 72205, USA
    Clin Cancer Res 12:4112-8. 2006
    ..This study assessed the role of the two major neuropeptides released by sensory nerves, calcitonin gene-related peptide (CGRP) and substance P, in the intestinal radiation response...
  53. ncbi Mechanism of CGRP-induced vasodilation in the rat isolated perfused kidney
    Ilknur Ay
    Department of Pharmacology, Faculty of Medicine, Hacettepe University, Ankara, Turkey
    Pharmacology 71:209-15. 2004
    ....
  54. pmc Protective effect of proteinase-activated receptor 2 activation on motility impairment and tissue damage induced by intestinal ischemia/reperfusion in rodents
    Fiore Cattaruzza
    Center for Ulcer Research and Education, Digestive Diseases Research Center, Division of Digestive Diseases, Department of Medicine, David Geffen School of Medicine University of California, Los Angeles, California, USA
    Am J Pathol 169:177-88. 2006
    ..PAR(2) might be a signaling system in the neuroimmune communication in intestinal ischemia/reperfusion...
  55. ncbi Antithrombin reduces endotoxin-induced hypotension by enhancing pulmonary sensory neuron activation in rats
    Naoaki Harada
    Department of Biodefense Medicine, Nagoya City University, Graduate School of Medical Sciences, Kawasumi 1, 1 1 1 Nagoya 467 8601, Japan
    Thromb Haemost 95:1011-8. 2006
    ..These results strongly suggested that AT might reduce endotoxin-induced hypotension in rats by enhancing activation of sensory neurons via activation of protein kinase A...
  56. ncbi Evidence for decreased calcitonin gene-related peptide (CGRP) receptors and compromised responsiveness to CGRP of fetoplacental vessels in preeclamptic pregnancies
    Yuan Lin Dong
    Department of Obstetrics and Gynecology, University of Texas Medical Branch, 301 University Boulevard, Medical Research Building, 11 138, Galveston, Texas 77555 1062, USA
    J Clin Endocrinol Metab 90:2336-43. 2005
    ..We concluded that CGRP may contribute to the low fetoplacental vascular resistance in normal pregnancies; however, CGRP-dependent vascular relaxation appears to be compromised in preeclamptic pregnancies...
  57. ncbi Exogenous and endogenous ghrelin in gastroprotection against stress-induced gastric damage
    T Brzozowski
    Department of Physiology, Jagiellonian University Medical College, 16, Grzegorzecka Street, 31 531 Cracow, Poland
    Regul Pept 120:39-51. 2004
    ..We conclude that ghrelin exerts a potent protective action on the stomach of rats exposed to ethanol and WRS, and these effects depend upon vagal activity, sensory nerves and hyperemia mediated by NOS-NO and COX-PG systems...
  58. pmc Characterization and effects on cAMP accumulation of adrenomedullin and calcitonin gene-related peptide (CGRP) receptors in dissociated rat spinal cord cell culture
    Mohammad A Takhshid
    Fasa Medical School, Shiraz University of Medical Sciences, Shiraz, Iran
    Br J Pharmacol 148:459-68. 2006
    ..30) on cAMP accumulation. These pharmacological profiles suggest that effects of CGRP are mediated by the CGRP(1) (CLR/RAMP1) receptor in our model while those of AM are related to the activation of the AM(1) (CLR/RAMP2) receptor subtype...
  59. ncbi Nitroglycerin-induced release of calcitonin gene-related peptide from sensory nerves attenuates the development of nitrate tolerance
    Srinivas Ghatta
    Department of Pharmaceutical Sciences North Dakota State University, Fargo, North Dakota 58105 5055, USA
    J Cardiovasc Pharmacol 47:175-81. 2006
    ....
  60. ncbi Cys2,7EtalphaCGRP is a potent agonist for CGRP1 receptors in SK-N-MC cells
    Christina Nodin
    Preclinical Research and Development, AstraZeneca Mölndal, 43183 Molndal, Sweden
    Biochem Pharmacol 69:1235-40. 2005
    ..Differences between the agonistic profile of this ligand in this and other experimental systems might be species--or even cell type--dependent...
  61. ncbi Characterisation of CGRP receptors in human and porcine isolated coronary arteries: evidence for CGRP receptor heterogeneity
    Saurabh Gupta
    Department of Pharmacology, University Medical Center Rotterdam, The Netherlands
    Eur J Pharmacol 530:107-16. 2006
    ....
  62. ncbi Effects of neuropeptides on the sumatriptan-disturbed circulation in the optic nerve head of rabbits
    M N Gaspar
    Department of Pharmacology, Institute of Biomedical Research on Light and Image, Faculty of Medicine, University of Coimbra, Coimbra, Portugal
    Pharmacology 70:152-9. 2004
    ..2+/-2.9%), antagonized by the tachykinin receptor antagonists and CGRP8-37. These results suggest, for the first time, the presence of NK1, NK2, and CGRP receptors on the retinal arteriolar wall of the rabbit...
  63. ncbi Role of CGRP and GABA in the hypotensive effect of intrathecally administered anandamide to anesthetized rats
    Maria del Carmen Garcia
    Catedra de Farmacologia, Facultad de Farmacia y Bioquímica Universidad de Buenos Aires, Junin 956, 5o piso, 1113 Buenos Aires, Argentina
    Eur J Pharmacol 532:88-98. 2006
    ..NO does not appear to have a direct participation in the spinal mechanisms involved in the decrease of the blood pressure caused by anandamide...
  64. ncbi Calcitonin gene-related peptides: their binding sites and receptor accessory proteins in adult mammalian skeletal muscles
    H L Fernandez
    Research and Development Service 151, Department of Veterans Affairs Medical Center, PO Box 4125, Bay Pines, FL 33744, USA
    Neuroscience 119:335-45. 2003
    ....
  65. ncbi Antinociceptive effect of calcitonin gene-related peptide in the central nucleus of amygdala: activating opioid receptors through amygdala-periaqueductal gray pathway
    W Xu
    Department of Physiology, College of Life Sciences, Peking University, Beijing 100871, China
    Neuroscience 118:1015-22. 2003
    ..The results indicate that CGRP activates the met-enkephalinergic neurons, which project from CeA to the periaqueductal gray, producing antinociceptive effect in rats...
  66. ncbi Mechanisms of vasodilation in the dorsal aorta of the elephant fish, Callorhinchus milii (Chimaeriformes: Holocephali)
    Brett L Jennings
    School of Life and Environmental Sciences, Deakin University, Geelong, Vic, 3217, Australia
    J Comp Physiol B 177:557-67. 2007
    ..We propose that nicotine is mediating a neurally-derived vasodilation in the dorsal aorta that is independent of NO, prostaglandins and the endothelium, and partly mediated by CGRP...
  67. ncbi Infusion of pregnant rats with calcitonin gene-related peptide (CGRP)(8-37), a CGRP receptor antagonist, increases blood pressure and fetal mortality and decreases fetal growth
    P R R Gangula
    Department of Obstetrics Gynecology, The University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555 1062, USA
    Biol Reprod 67:624-9. 2002
    ..Therefore, we suggest that endogenous CGRP plays an important role in maintaining normal fetoplacental development, fetal survival, and vascular adaptations during pregnancy...
  68. pmc Increased GFR and renal excretory function by activation of TRPV1 in the isolated perfused kidney
    Jianping Li
    Department of Medicine, Neuroscience Program, and Cell and Molecular Biology Program, Michigan State University, East Lansing, MI 48824, USA
    Pharmacol Res 57:239-46. 2008
    ....
  69. ncbi Production of cAMP by adrenomedullin in human oligodendroglial cell line KG1C: comparison with calcitonin gene-related peptide and amylin
    Y Uezono
    Department of Pharmacology, Miyazaki Medical College, 5200 Kihara, 889 1692, Kiyotake, Japan
    Brain Res Mol Brain Res 97:59-69. 2001
    ..Collectively, these findings imply that AM released from oligodendroglial cells may play a role in the regulation of oligodendrocytes via autocrine/paracrine through AM receptors and CGRP(1) receptors...
  70. ncbi Vasodilatation in hyperalgesic rat skin evoked by stimulation of afferent A beta-fibers: further evidence for a role of dorsal root reflexes in allodynia
    E Garcia-Nicas
    Department of Physiology, , , E-28871 Madrid, Spain
    Pain 94:283-91. 2001
    ..These results support our hypothesis by showing activation of nociceptive primary afferents by A beta-fibers in areas of allodynia in a manner consistent with a pre-synaptic interaction evoking dorsal root reflexes...
  71. ncbi Analysis of responses to hAmylin, hCGRP, and hADM in isolated resistance arteries from the mesenteric vascular bed of the rat
    H C Champion
    Department of Pharmacology, Tulane University School of Medicine, New Orleans, LA 70112, USA
    Peptides 22:1427-34. 2001
    ..These data suggest that hCGRP and hAmylin have direct vasodilator effects in the isolated mesenteric resistance artery that are mediated by hAmylin-(8-37)- and hCGRP-(8-37)-sensitive receptors...
  72. ncbi Modulatory effect of two novel CGRP receptor antagonists on nasal vasodilatatory responses to exogenous CGRP, capsaicin, bradykinin and histamine in anaesthetised pigs
    D D Malis
    Laboratory of Experimental Rhinology, Clinic of Otorhinolaryngology, University Hospital, CH-1211, Geneva, Switzerland
    Regul Pept 101:101-8. 2001
    ..In addition, they may have putative therapeutic applications in the treatment of rhinitic patients suffering from chronic nasal obstruction...
  73. ncbi Calcitonin gene-related peptide (CGRP), acting via CGRP type 1 receptors, inhibits potassium-stimulated aldosterone secretion and enhances basal catecholamine secretion from rat adrenal gland
    C Tortorella
    Department of Human Anatomy and Physiology, Section of Anatomy, University of Padua, Via Gabelli 65, I-35121 Padua, Italy
    Int J Mol Med 8:261-4. 2001
    ..The conclusion is drawn that CGRP, like ADM, inhibits agonist-stimulated aldosterone secretion and stimulates basal catecholamine release in the rat, exclusively acting via CGRP1 receptors...
  74. ncbi The transmembrane domain of receptor-activity-modifying protein 1 is essential for the functional expression of a calcitonin gene-related peptide receptor
    Sarah Steiner
    Research Laboratory for Calcium Metabolism, Department of Orthopedic Surgery, University of Zurich, Klinik Balgrist, 8008 Zurich, Switzerland
    Biochemistry 41:11398-404. 2002
    ..The entire single transmembrane domain of hRAMP1 together with one hydrophilic amino acid residue at its C-terminus is required for the formation of a fully functional CGRP/hRAMP1/hCRLR receptor complex...
  75. ncbi Homologous desensitization of calcitonin gene-related peptide-induced relaxation in rat intramural coronary arteries
    Majid Sheykhzade
    Department of Pharmacology, The Danish University of Pharmaceutical Sciences, Universitetsparken 2, DK 2100 Ø, Copenhagen, Denmark
    Eur J Pharmacol 484:91-101. 2004
    ..In conclusion, these results suggest that development of tachyphylaxis to CGRP in U46619-precontracted coronary is related to CGRP receptor-mediated activation of protein kinase...
  76. pmc Interdependent regulation of afferent renal nerve activity and renal function: role of transient receptor potential vanilloid type 1, neurokinin 1, and calcitonin gene-related peptide receptors
    Chaoqin Xie
    Department of Medicine, Michigan State University, East Lansing, MI 48824, USA
    J Pharmacol Exp Ther 325:751-7. 2008
    ..Taken together, our data indicate that NK1 activation induced by SP release upon TRPV1 activation governs TRPV1 function and that a TRPV1-dependent mechanism is operant in CGRP action...
  77. ncbi Pharmacologic study of C-terminal fragments of frog skin calcitonin gene-related peptide
    Ali Ladram
    Peptidome de la Peau des Amphibiens, FRE2852, Universite Pierre et Marie Curie Paris 6, Tour 43, 2 place Jussieu, 75251 Paris Cedex 05, France
    Peptides 29:1150-6. 2008
    ..pbCGRP(27-37) was also as potent as [D(31), A(34), F(35)] halphaCGRP(27-37), a prototypic antagonist analog derived from structure-activity relationship studies of halphaCGRP(8-37)...
  78. ncbi Adrenomedullin-2/intermedin induces cAMP accumulation in dissociated rat spinal cord cells: evidence for the existence of a distinct class of sites of action
    Ali Akbar Owji
    Department of Biochemistry, Shiraz University of Medical Sciences, Shiraz, Fars, Iran
    J Mol Neurosci 35:355-61. 2008
    ..Taken together, these data provide evidence for the possible existence of a distinct class of receptor sites for adrenomedullin-2/intermedin in embryonic rat spinal cord cells...
  79. ncbi Endotoxin inhibits gastric emptying in rats via a capsaicin-sensitive afferent pathway
    S Calatayud
    Department of Pharmacology, Faculty of Medicine, University of Valencia, Spain
    Naunyn Schmiedebergs Arch Pharmacol 363:276-80. 2001
    ..1 mg/kg i.p.) failed to reverse the delay in gastric emptying induced by endotoxin. These observations indicate that endotoxin-induced delay in gastric emptying of a solid nutrient meal is mediated by capsaicin-sensitive afferent neurons...
  80. pmc Interaction of human adrenomedullin 13-52 with calcitonin gene-related peptide receptors in the microvasculature of the rat and hamster
    J M Hall
    Biomedical Sciences Division, King s College London
    Br J Pharmacol 114:592-7. 1995
    ..It mediates its vasodilator effect by arteriolar dilatation and this effect is due, at least in part, to the stimulation of CGRPI receptors...
  81. ncbi Calcitonin gene-related peptide regulates expression of neurokinin1 receptors by rat spinal neurons
    Virginia S Seybold
    Department of Neuroscience, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Neurosci 23:1816-24. 2003
    ..The data provide evidence that a neuropeptide receptor controls gene expression in the CNS and add another dimension to understanding the cotransmission of substance P and CGRP by primary afferent neurons...
  82. ncbi Calcitonin gene-related peptide8-37 antagonizes capsaicin-induced vasodilation in the skin: evaluation of a human in vivo pharmacodynamic model
    B J Van der Schueren
    Center for Clinical Pharmacology, University Hospital Gasthuisberg, Herestraat 49, 3000 Leuven, Belgium
    J Pharmacol Exp Ther 325:248-55. 2008
    ..The response to capsaicin does not display a circadian rhythm. A pharmacodynamic model is proposed to evaluate CGRP receptor antagonists in humans in vivo...
  83. pmc The role of the 8-18 helix of CGRP8-37 in mediating high affinity binding to CGRP receptors; coulombic and steric interactions
    Stephen G Howitt
    Pharmaceutical Sciences Research Institute, Aston University, Birmingham, B4 7ET
    Br J Pharmacol 138:325-32. 2003
    ..Leu(16) is in a conformationally restricted site when CGRP(8-37) binds to CGRP(1) receptors, unlike Leu(12) and Leu(15)...
  84. ncbi Responses to human CGRP, ADM, and PAMP in human thymic arteries
    Hunter C Champion
    Department of Pharmacology, Tulane University Health Sciences Center, New Orleans, Louisiana 70112, USA
    Am J Physiol Regul Integr Comp Physiol 284:R531-7. 2003
    ..A different endothelial receptor recognizes PAMP and signals by a nitric oxide-dependent mechanism...
  85. ncbi Investigation of CGRP receptors and peptide pharmacology in human coronary arteries. Characterization with a nonpeptide antagonist
    Philip Hasbak
    Department of Clinical Experimental Research, University Hospital of Copenhagen, Glostrup, Denmark
    J Pharmacol Exp Ther 304:326-33. 2003
    ..alphaCGRP, AM, and amylin mediated vasorelaxation via the CGRP1 receptor. Compound 1 acted as a nonpeptide antagonist at the CGRP1 receptor and could thus become a tool for the study of CGRP-mediated functional responses in human tissue...
  86. ncbi Sequencing of a calcitonin receptor-like receptor in salmon Oncorhynchus gorbuscha. Functional studies using the human receptor activity-modifying proteins
    Elisabeth Pidoux
    U 349 Institut National de la Santé et de la Recherche Médicale, 6 rue Guy Patin, Centre Viggo Petersen, 75475 Paris Cedex 10, France
    Gene 298:203-10. 2002
    ..The availability of this receptor must allow to further study their structural basis. This identification of a non-mammalian CL receptor, and characterization of its function, give insight in the evolution of the CL receptor molecule...
  87. ncbi Increased depressor response to N-arachidonoyl-dopamine during high salt intake: role of the TRPV1 receptor
    Youping Wang
    Department of Medicine, Neuroscience Program, and Cell and Molecular Biology Program, Michigan State University, East Lansing, Michigan 48824, USA
    J Hypertens 25:2426-33. 2007
    ....
  88. ncbi TRPV1 receptor signaling mediates afferent nerve sensitization during colitis-induced motility disorders in rats
    H U De Schepper
    Laboratory of Gastroenterology, Faculty of Medicine, Univ of Antwerp, Universiteitsplein 1, 2610 Antwerp Belgium
    Am J Physiol Gastrointest Liver Physiol 294:G245-53. 2008
    ..We provided pharmacological, immunocytochemical, and molecular biological evidence that this sensitization is mediated by TRPV1 receptors and involves CGRP release...
  89. ncbi Adrenomedullin inhibits doxorubicin-induced cultured rat cardiac myocyte apoptosis via a cAMP-dependent mechanism
    Takeshi Tokudome
    Research Institute, National Cardiovascular Center, Suita, Osaka 565 8565, Japan
    Endocrinology 143:3515-21. 2002
    ..AM, as an autocrine factor, may play a protective role against cardiomyocyte injury by doxorubicin...
  90. pmc A comparison of the actions of BIBN4096BS and CGRP(8-37) on CGRP and adrenomedullin receptors expressed on SK-N-MC, L6, Col 29 and Rat 2 cells
    Debbie L Hay
    Pharmaceutical Sciences Research Institute, Aston University, Aston Triangle, Birmingham B4 7ET
    Br J Pharmacol 137:80-6. 2002
    ..Its slow kinetics may explain its apparent 'non-competitive' behaviour. At concentrations of up to 10 micro M, it has no antagonist actions at the adrenomedullin, CRLR/RAMP2 receptor, unlike CGRP(8-37)...
  91. pmc Pharmacological characterisation of capsaicin-induced relaxations in human and porcine isolated arteries
    Saurabh Gupta
    Department of Pharmacology, Erasmus MC, University Medical Center Rotterdam, 3000 DR, Rotterdam, The Netherlands
    Naunyn Schmiedebergs Arch Pharmacol 375:29-38. 2007
    ..Therefore, these relaxant responses to capsaicin are likely to be attributed to a non-specific, CGRP-independent mechanism...
  92. ncbi Proton acts as a neurotransmitter for nicotine-induced adrenergic and calcitonin gene-related peptide-containing nerve-mediated vasodilation in the rat mesenteric artery
    Hiromu Kawasaki
    Department of Clinical Pharmaceutical Science, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 1 1 1 Tsushima naka, Okayama 700 8530, Japan
    J Pharmacol Exp Ther 330:745-55. 2009
    ..These results indicate that nicotine initially stimulates adrenergic nerves via nicotinic alpha(3)beta(4)-receptors to release protons and thereby induces CGRPergic nerve-mediated vasodilation via TRPV1...
  93. ncbi Role of afferent nerves and sensory peptides in the mediation of hepatic artery buffer response
    J Biernat
    Department of Physiology, Jagiellonian University, Medical College, Cracow, Poland
    J Physiol Pharmacol 56:133-45. 2005
    ..The observed vasodilation in the vascular bed of the hepatic artery is due to stimulation of CGRP and NK-1 receptors...
  94. pmc Characterization of the receptor and the mechanisms underlying the inflammatory response induced by des-Arg9-BK in mouse pleurisy
    R M Vianna
    Department of Pharmacology, Centre of Biological Sciences, Universidade Federal de Santa Catarina, , Brazil
    Br J Pharmacol 123:281-91. 1998
    ....
  95. ncbi Development of angiotensin II-induced hypertension: role of CGRP and its receptor
    Jianping Li
    Department of Medicine and Pharmacology and Toxicology, Michigan State University, East Lansing, Michigan 48824, USA
    J Hypertens 23:113-8. 2005
    ..To determine the role of endogenous calcitonin gene-related peptide (CGRP) and its receptor in development of angiotensin II (Ang II)-induced hypertension...
  96. ncbi Differential distribution of calcitonin gene-related peptide and its receptor components in the human trigeminal ganglion
    S Eftekhari
    Department of Clinical Sciences, Division of Experimental Vascular Research, Lund University, Lund, Sweden
    Neuroscience 169:683-96. 2010
    ..This suggests a possible site of action for the novel CGRP receptor antagonists in migraine therapy...
  97. pmc Vanilloid receptors on capsaicin-sensitive sensory nerves mediate relaxation to methanandamide in the rat isolated mesenteric arterial bed and small mesenteric arteries
    V Ralevic
    School of Biomedical Sciences, University of Nottingham Medical School, Queen s Medical Centre, Nottingham NG7 2UH
    Br J Pharmacol 130:1483-8. 2000
    ..In conclusion, vanilloid receptors on capsaicin-sensitive sensory nerves play an important role in the vasorelaxant action of methanandamide in the rat isolated mesenteric arterial bed and small mesenteric arterial segments...
  98. pmc The anti-migraine 5-HT(1B/1D) agonist rizatriptan inhibits neurogenic dural vasodilation in anaesthetized guinea-pigs
    D J Williamson
    Department of Pharmacology, Merck Sharp and Dohme Research Laboratories, Neuroscience Research Centre, Terlings Park, Harlow, Essex, CM20 2QR, UK
    Br J Pharmacol 133:1029-34. 2001
    ....
  99. pmc Transient receptor potential vanilloid subtype 1 channel mediated neuropeptide secretion and depressor effects: role of endoplasmic reticulum associated Ca2+ release receptors in rat dorsal root ganglion neurons
    Wei Huang
    Department of Medicine and Pharmacology and Toxicology, Michigan State University, East Lansing, Michigan 48824, USA
    J Hypertens 26:1966-75. 2008
    ....
  100. ncbi Neuropeptide receptor transcripts are expressed in the rat clitoris and oscillate during the estrus cycle in the rat vagina
    David Dangoor
    Department of Clinical Biochemistry, Sackler School of Medicine, Tel Aviv University, Einstein Street, 69978 Tel Aviv, Israel
    Peptides 26:2579-84. 2005
    ..The expression pattern of neuropeptide receptors in the female sexual organs suggest an intimate involvement of the corresponding neuropeptides in female sexual function...
  101. ncbi Calcitonin gene-related peptide receptor expression in the neurons and glia of developing rat cerebellum: an autoradiographic and immunohistochemical analysis
    S Morara
    Istituto Neuroscienze e Bioimmagini CNR, 20131, Milano, Italy
    Neuroscience 100:381-91. 2000
    ..As a result of glia-neuron interactions, an indirect effect on the differentiation of the cerebellar neuronal circuitry is also likely to occur...

Research Grants29

  1. Autonomic and Antihypertensive Actions of Neuronal CGRP/RAMP1 Receptors
    Mark W Chapleau; Fiscal Year: 2013
    ..Inhibition of Ang II-mediated effects by activation of CGRP/RAMP1 receptors has widespread implications in hypertension and heart failure. ..
  2. The role of BNST CGRP in stress-enhanced anxiety behavior and HPA-axis function
    Kelly S Sink; Fiscal Year: 2013
    ....
  3. Neurogenic inflammation and psoriasiform dermatitis
    NICOLE LEANNE WARD; Fiscal Year: 2013
    ....
  4. The role of stress and mast cells in a preclinical mouse model of migraine
    ANN CHRISTINE RADDANT; Fiscal Year: 2013
    ..Additionally, it will provide some insight into the mechanism of how stress precipitates migraine. Overall, this project will assess the first evidence of a physiological trigger of a migraine symptom in an animal model. ..
  5. CGRP-induced light aversion in a preclinical migraine model
    Andrew F Russo; Fiscal Year: 2013
    ..The impact of this proposal will be a validated preclinical model for translational studies to develop new therapeutics for migraine. ..
  6. Treat Neuropathic Pain with Dissolvable Microneedles Containing Anti-CGRP Peptide
    Xinmin Simon Xie; Fiscal Year: 2013
    ....
  7. Development of a Mouse Trigeminal Pain Model
    ANDREW RUSSO; Fiscal Year: 2009
    ....
  8. Coronary Dysregulation Associated with Obesity
    Christine L Oltman; Fiscal Year: 2013
    ..With the global increase in type II diabetes and onset of obesity increasing in younger populations, the burden to deliver health care to these individuals will continue to increase. ..
  9. MOLECULAR BIOLOGY OF COCHLEAR EFFERENT RECEPTORS
    Anne Luebke; Fiscal Year: 2009
    ..Information gained from these studies will provide direct assessment of the molecular mechanisms used by the CGRP efferent feedback pathway to enhance sound-evoked activity in the cochlear nerve. ..
  10. Neuronal Plasticity Related to TMD and Fibromyalgia
    Dean Dessem; Fiscal Year: 2006
    ..Because a gender difference is reported for TMD and FM, both hypotheses will be tested in males, estrous females and diestrous females. ..
  11. NEUROGENIC MECHANISMS OF INTESTINAL INFLAMMATION
    Eileen Grady; Fiscal Year: 2006
    ..Together, the results of these experiments will provide new insights into peptide signaling, generate novel information about mechanisms of intestinal inflammation, and suggest new strategies for therapy. ..
  12. Ontogeny of CRLR and RAMPs in Myometrium
    Chandrasekhar Yallampalli; Fiscal Year: 2002
    ..A necessary first step is the development of quality reagents to aid in this study and for further use in probing receptor structure/function relationships. ..
  13. UV, Neuropeptides, Histamine and Buruli Ulcer Disease
    RHIAN COPE; Fiscal Year: 2005
    ..Irrespective of the outcomes of these experiments, new and important information on BUD pathogenesis will be obtained. ..
  14. Efferent Signaling through the CGRP receptor complex
    RHIANNON BUSSEY; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  15. Human Fetoplacental Vasculature and CGRP
    Yuan Lin Dong; Fiscal Year: 2005
    ..Our results may indicate that CGRP has vasodilatory effects on human fetoplacental vasculature and is regulated by sex steroid hormones, as well as elucidate the role of CGRP in IUGR and/or preeclampsia. ..
  16. Molecular Mechanisms Critical to CGRP Receptor Signaling
    James Porter; Fiscal Year: 2003
    ....
  17. Inflammatory Signaling Mechanisms of the CGRP Receptor
    James Porter; Fiscal Year: 2004
    ..abstract_text> ..
  18. MOLECULAR BIOLOGY OF COCHLEAR EFFERENT RECEPTORS
    Anne Luebke; Fiscal Year: 2000
    ..Information gained from these studies may contribute to future drug therapies that target the cochlear efferents system, and thus, help decrease the occurrence of, and improve the treatment for patients with high-frequency hearing loss. ..
  19. Adrenomedullin and Human Trophoblast Invasion
    Yuan Lin Dong; Fiscal Year: 2006
    ..Knowledge gained from these studies may assist in designing appropriate therapeutic strategies to prevent preeclampsia in the human. ..
  20. Low birth weight, uterine infection, and nitric oxide
    Chandrasekhar Yallampalli; Fiscal Year: 2007
    ..2 will test the hypothesis that NO donor can reverse the increases in DAF expression in uteroplacental and vascular tissues and in fetal growth restriction ..
  21. Nitric Oxide Control of CGRP in Trigeminal Neurons
    Paul Durham; Fiscal Year: 2002
    ..abstract_text> ..
  22. Regulation of B Cell Development by Neuropeptides
    JOSEPH MCGILLIS; Fiscal Year: 2005
    ..A better understanding of CGRP's role in B cell development may offer new avenues for new therapeutic approaches. ..
  23. Keratinocyte-derived immuno-suppressive cytokines
    Stephen Ullrich; Fiscal Year: 2005
    ..A better understanding of the mechanisms involved may help with the design of rational approaches to block the induction of immune suppression, thereby reducing one of the major risk factors for skin cancer induction. ..
  24. Do NKT cells mediate UV induced Immune Suppression?
    Stephen Ullrich; Fiscal Year: 2005
    ..A better understanding of the mechanisms involved in UV-induced immune suppression may help with the design of rational approaches to block immune suppression, thereby reducing one of the major risk factors for skin cancer induction. ..
  25. Characterization of Neuroendocrine CGRP Receptors
    Ian Dickerson; Fiscal Year: 2006
    ..abstract_text> ..
  26. CGRP CONTROL IN TRIGEMINAL NEURONS IN VITRO AND IN VIVO
    Paul Durham; Fiscal Year: 2006
    ..abstract_text> ..
  27. CGRP Regulation of iNOS and MAP Kinases/Phosphatases in Trigeminal Ganglia Glia
    Paul L Durham; Fiscal Year: 2010
    ....
  28. Peptidergic Neurotransmission in the Spinal Cord
    VIRGINIA SEYBOLD; Fiscal Year: 2009
    ..If the hypothesis is proven to be true, the data will provide evidence for a new therapeutic strategy that may be effective in treating peripheral inflammatory diseases. ..
  29. Inflammatory mediators and UV-induced carcinogenesis
    Stephen Ullrich; Fiscal Year: 2009
    ..The focus of the studies presented here is to provide evidence to support the hypothesis that these drugs can act as novel agents to prevent skin cancer formation. ..