Genomes and Genes
Summary: Cell surface proteins that bind ANGIOTENSINS and trigger intracellular changes influencing the behavior of cells.
Publications256 found, 100 shown here
- Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathyB M Brenner
Renal Division, Brigham and Women s Hospital, Boston, MA 02115, USA
N Engl J Med 345:861-9. 2001..We assessed the role of the angiotensin-II-receptor antagonist losartan in patients with type 2 diabetes and nephropathy...
- International union of pharmacology. XXIII. The angiotensin II receptorsM De Gasparo
Novartis Pharma AG, Metabolic and Cardiovascular Diseases, Basel, Switzerland
Pharmacol Rev 52:415-72. 2000..The development of specific nonpeptide receptor antagonists has led to major advances in the physiology, pharmacology, and therapy of the renin-angiotensin system...
- Renoprotective effect of the angiotensin-receptor antagonist irbesartan in patients with nephropathy due to type 2 diabetesE J Lewis
Department of Medicine, Rush-Presbyterian-St Luke's Medical Center, Chicago, IL 60612, USA
N Engl J Med 345:851-60. 2001..CONCLUSIONS: The angiotensin-II-receptor blocker irbesartan is effective in protecting against the progression of nephropathy due to type 2 diabetes. This protection is independent of the reduction in blood pressure it causes...
- Effects of different blood-pressure-lowering regimens on major cardiovascular events: results of prospectively-designed overviews of randomised trialsFiona Turnbull
Blood Pressure Lowering Treatment Trialists Collaboration, The George Institute for International Health, University of Sydney, PO Box 576, Newtown, Sydney, New South Wales 2042, Australia
Lancet 362:1527-35. 2003....
- Cardiovascular morbidity and mortality in the Losartan Intervention For Endpoint reduction in hypertension study (LIFE): a randomised trial against atenololBjorn Dahlof
Sahlgrenska University Hospital Ostra, Gothenburg, Swede
Lancet 359:995-1003. 2002..We aimed to establish whether selective blocking of angiotensin II improves LVH beyond reducing blood pressure and, consequently, reduces cardiovascular morbidity and death...
- Drugs targeting the renin-angiotensin-aldosterone systemMohammad Amin Zaman
Vascular Biology and Hypertension Program, Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
Nat Rev Drug Discov 1:621-36. 2002....
- The effect of irbesartan on the development of diabetic nephropathy in patients with type 2 diabetesH H Parving
Steno Diabetes Center, Copenhagen, Denmark
N Engl J Med 345:870-8. 2001..02). CONCLUSIONS: Irbesartan is renoprotective independently of its blood-pressure-lowering effect in patients with type 2 diabetes and microalbuminuria...
- Renoprotective properties of angiotensin receptor blockers beyond blood pressure loweringYuko Izuhara
Institute of Medical Sciences and Department of Internal Medicine, Tokai University School of Medicine, Kanagawa, Japan
J Am Soc Nephrol 16:3631-41. 2005..These benefits of ARB may contribute to the renoprotection observed beyond BP lowering...
- Angiotensin II and NGF differentially influence microtubule proteins in PC12W cells: role of the AT2 receptorU Stroth
Department of Pharmacology, Christian Albrechts University, Hospitalstrasse 4, D 24105 Kiel, Germany
Brain Res Mol Brain Res 53:187-95. 1998..These results implicate a specific role of AT2 receptors in cell differentiation and nerve regeneration via regulation of the cytoskeleton...
- Angiotensin II stimulates endothelial vascular cell adhesion molecule-1 via nuclear factor-kappaB activation induced by intracellular oxidative stressM E Pueyo
INSERM U460, Paris, France
Arterioscler Thromb Vasc Biol 20:645-51. 2000..This activation enhances the expression of VCAM-1 and probably other genes involved in the early stages of atherosclerosis...
- The renin-angiotensin-aldosterone system and the kidney: effects on kidney diseaseUrsula C Brewster
Section of Nephrology, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520 8029, USA
Am J Med 116:263-72. 2004....
- Angiotensin type 2 receptor dephosphorylates Bcl-2 by activating mitogen-activated protein kinase phosphatase-1 and induces apoptosisM Horiuchi
Department of Medicine, Harvard Medical School, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
J Biol Chem 272:19022-6. 1997..The AT2 receptor inhibits MAP kinase activation, resulting in the inactivation of Bcl-2 and the induction of apoptosis...
- Angiotensin receptors in the cardiovascular systemLodewijk J Wagenaar
University of Groningen, The Netherlands
Can J Cardiol 18:1331-9. 2002..Four types of angiotensin receptors are known, of which the type 1 (AT1) and the type 2 (AT2) receptors are the most important...
- Olmesartan medoxomil, an angiotensin II receptor blocker ameliorates insulin resistance and decreases triglyceride production in fructose-fed ratsKenta Okada
First Department of Internal Medicine, Showa University School of Medicine, Tokyo, Japan
Hypertens Res 27:293-9. 2004..Olmesartan ameliorates insulin resistance and overproduction of TG in fructose-fed rats, and these effects appear to be independent of its hypotensive action...
- The intracellular renin-angiotensin system: a new paradigmRajesh Kumar
Division of Molecular Cardiology, Cardiovascular Research Institute, Texas A and M Health Science Center, College of Medicine, Temple, TX 76508, USA
Trends Endocrinol Metab 18:208-14. 2007..A more comprehensive understanding of the intracellular RAS provides for new strategies in system regulation and a more efficacious approach to the management of RAS-related diseases...
- Distribution of type-1 and type-2 angiotensin receptors in the normal human lung and in lungs from patients with chronic obstructive pulmonary diseaseG R Bullock
Department of Pathology, Blok A 503, University Hospital, De Pintelaan 185, 9000 Ghent, Belgium
Histochem Cell Biol 115:117-24. 2001..This correlated well with the reduced lung function as expressed by the forced expiratory volume...
- Angiotensin II type 1 receptor gene polymorphisms in human essential hypertensionA Bonnardeaux
INSERM U36, College de France, Paris
Hypertension 24:63-9. 1994..These findings would be compatible with a common variant of the AT1 receptor imparting a small effect on blood pressure; further studies will be needed to address this possibility...
- Angiotensin II type 2 receptor mediates programmed cell deathT Yamada
Falk Cardiovascular Research Center, Stanford University School of Medicine, CA 94305 5246, USA
Proc Natl Acad Sci U S A 93:156-60. 1996..We hypothesize that this apoptotic function of the AT2 receptor may play an important role in developmental biology and pathophysiology...
- Emerging features of brain angiotensin receptorsJ M Saavedra
Section on Pharmacology, National Institute of Mental Health, Bethesda, MD 20892, USA
Regul Pept 85:31-45. 1999....
- Valsartan, captopril, or both in myocardial infarction complicated by heart failure, left ventricular dysfunction, or bothMarc A Pfeffer
Cardiovascular Division, Brigham and Women s Hospital, Boston, MA 02115, USA
N Engl J Med 349:1893-906. 2003..In a double-blind trial, we compared the effect of the angiotensin-receptor blocker valsartan, the ACE inhibitor captopril, and the combination of the two on mortality in this population of patients...
- Angiotensin receptors in the nervous systemA M Allen
The Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Parkville, Victoria, Australia
Brain Res Bull 47:17-28. 1998..This review examines the distribution of these specific angiotensin receptors and discusses evidence regarding the function of angiotensin peptides in various brain regions...
- Renin-angiotensin system and cardiovascular riskRoland E Schmieder
Department of Nephrology and Hypertension, University of Erlangen Nuremberg, 91054 Erlangen, Germany
Lancet 369:1208-19. 2007..Thus, blockade of this system will remain a cornerstone of our strategies to reduce cardiovascular risk...
- Molecular and cellular mechanisms of angiotensin II-mediated cardiovascular and renal diseasesS Kim
Department of Pharmacology, Osaka City University Medical School, Abeno Ku, Osaka, Japan
Pharmacol Rev 52:11-34. 2000..However, there are still unresolved questions and controversies on the mechanism of Ang II-mediated cardiovascular and renal diseases...
- Reduction of morbidity and mortality by statins, angiotensin-converting enzyme inhibitors, and angiotensin receptor blockers in patients with chronic obstructive pulmonary diseaseG B John Mancini
Division of Cardiology, Vancouver Hospital, Jack Bell Research Centre, University of British Columbia, Vancouver, British Columbia, Canada
J Am Coll Cardiol 47:2554-60. 2006....
- Angiotensin receptors as determinants of life spanPaola Cassis
Mario Negri Institute for Pharmacological Research, Via Gavazzeni, 11, 24125 Bergamo, Italy
Pflugers Arch 459:325-32. 2010....
- beta-Arrestin 1 and 2 differentially regulate heptahelical receptor signaling and traffickingT A Kohout
Howard Hughes Medical Institute, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
Proc Natl Acad Sci U S A 98:1601-6. 2001..These findings suggest that sequestration of various heptahelical receptors is regulated differently by the two beta-arrestins, whereas both isoforms are capable of supporting receptor desensitization and down-regulation...
- The renin-angiotensin-aldosterone system: a specific target for hypertension managementM R Weir
Department of Medicine, University of Maryland School of Medicine, Baltimore, USA
Am J Hypertens 12:205S-213S. 1999....
- Angiotensin II activates nuclear transcription factor-kappaB through AT1 and AT2 receptorsGunter Wolf
Division of Nephrology and Osteology, Department of Medicine, University of Hamburg, Hamburg, Germany
Kidney Int 61:1986-95. 2002..We focused particularly on the Ang II subtype 2 (AT2) receptor because we previously observed that Ang II-induction of the chemokine RANTES in vitro and in vivo is mediated through AT2 receptors...
- Maternal undernutrition during early to midgestation programs tissue-specific alterations in the expression of the glucocorticoid receptor, 11beta-hydroxysteroid dehydrogenase isoforms, and type 1 angiotensin ii receptor in neonatal sheepC B Whorwood
Endocrinology and Metabolism Unit, Division of the Fetal Origins of Adult Disease, School of Medicine, Southampton General Hospital, Southampton, United Kingdom SO16 6YD
Endocrinology 142:2854-64. 2001....
- The angiotensin AT4 receptor subtype as a target for the treatment of memory dysfunction associated with Alzheimer's diseaseJohn W Wright
Department of Psychology, Veterinary and Comparative Anatomy, Pharmacology, and Physiology, Washington State University, P O Box 644820, Pullman, WA 99164 4820, USA
J Renin Angiotensin Aldosterone Syst 9:226-37. 2008..We conclude with a working hypothesis concerning the importance of the AT4 receptor subtype as a new potential drug target for the treatment of Alzheimer's disease-associated memory loss...
- New insights into the regulation of angiotensin receptorsMasaki Mogi
Department of Molecular Cardiovascular Biology and Pharmacology, Ehime University, Graduate School of Medicine, Shitsukawa, Tohon, Ehime, Japan
Curr Opin Nephrol Hypertens 18:138-43. 2009..These emerging concepts of regulation of Ang II receptors and a new insight into future drug discovery are discussed in this review...
- Cross-talk between AT(1) and AT(2) angiotensin receptors in rat anococcygeus smooth muscleMarcio A F de Godoy
Department of Pharmacology, School of Medicine of Ribeirao Preto, University of Sao Paulo, Brazil
J Pharmacol Exp Ther 303:333-9. 2002..Results indicate the presence of a heterogeneous angiotensin receptor population in the rat anococcygeus muscle following a negative cross-talk relationship between the AT(1) and AT(2) subtypes...
- Angiotensin II subtype 2 receptor blockade and deficiency attenuate the development of atherosclerosis in an apolipoprotein E-deficient mouse model of diabetesA Koitka
JDRF Danielle Alberti Memorial Centre for Diabetic Complications, Diabetes Division, Baker IDI Heart and Diabetes Research Institute, PO Box 6492, St Kilda Road Central, Melbourne, VIC 8008, Australia
Diabetologia 53:584-92. 2010..The aim of this study was to investigate the role of AT(2)R in diabetes-associated atherosclerosis using pharmacological blockade and genetic deficiency...
- Angiotensin II in cardiac pressure-overload hypertrophy in fetal sheepJ L Segar
Department of Pediatrics, University of Iowa, Iowa City, IA 52242, USA
Am J Physiol Regul Integr Comp Physiol 281:R2037-47. 2001..Elevated ANG II levels produce a selective increase in LV mass in the fetal sheep that is, in part, independent of increased systolic load...
- Effects of gestation on ovine fetal and maternal angiotensin receptor subtypes in the heart and major blood vesselsJ H Burrell
School of Physiology and Pharmacology, University of New South Wales, Sydney 2052, Australia
Exp Physiol 86:71-82. 2001..Experimental Physiology (2001) 86.1, 71-82...
- Recent advances in angiotensin II signalingR M Touyz
Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, University of Montreal, Quebec, Canada
Braz J Med Biol Res 35:1001-15. 2002....
- Control of dendritic cell differentiation by angiotensin IIKaren A Nahmod
Laboratory of Immunology, Institute of Hematologic Research, National Academy of Medicine, Buenos Aires, Argentina
FASEB J 17:491-3. 2003..Our results support the notion that the differentiation of DC is regulated by AII...
- The angiotensin II type 2 (AT2) receptor promotes axonal regeneration in the optic nerve of adult ratsR Lucius
Institute of Anatomy, Christian Albrechts University Kiel, D 24105 Kiel, Germany
J Exp Med 188:661-70. 1998....
- Maternal autoantibodies from preeclamptic patients activate angiotensin receptors on human trophoblast cellsYang Xia
Department of Biochemistry and Molecular Biology, Houston, Texas 77303, USA
J Soc Gynecol Investig 10:82-93. 2003..We sought to evaluate the role of AT1 agonistic autoantibodies (AT1-AA) in two major features of preeclampsia-increased plasminogen activator inhibitor-1 (PAI-1) production and shallow trophoblast invasion...
- Molecular cloning of AT1 angiotensin receptorsT J Murphy
Division of Cardiology, Emory University School of Medicine, Atlanta, GA 30322
Am J Hypertens 5:236S-242S. 1992..However, the tissue-specific expression pattern of the AT1b gene differs significantly from that for the AT1a receptor...
- Sequential development of angiotensin receptors and angiotensin I converting enzyme during angiogenesis in the rat subcutaneous sponge granulomaD A Walsh
Inflammation Group, London Hospital Medical College, Whitechapel
Br J Pharmacol 120:1302-11. 1997..Pharmacological modulation of this balance may provide novel therapeutic approaches in angiogenesis-dependent diseases...
- Angiotensin receptors: signaling, vascular pathophysiology, and interactions with ceramideC Berry
Department of Medicine and Therapeutics, Western Infirmary, University of Glasgow, G11 6NT Glasgow, United Kingdom
Am J Physiol Heart Circ Physiol 281:H2337-65. 2001..This may be clinically relevant, inasmuch as inhibitors of the RAS are increasingly used in treatment of hypertension and coronary heart disease, where activation of the RAS is recognized...
- Agonistic and antagonistic properties of angiotensin analogs at the AT2 receptor in PC12W cellsV Brechler
Cardiovascular Research Department, Pharmaceuticals Division, Ciba Geigy Ltd, Basel, Switzerland
Regul Pept 44:207-13. 1993..We found CGP 42112 to behave as a full agonist in this system, whereas PD 123319 and Sar Ile angiotensin II act as antagonists. As expected, the AT1 antagonist losartan did not affect this response...
- Crosstalk between presynaptic angiotensin receptors, bradykinin receptors and alpha 2-autoreceptors in sympathetic neurons: a study in alpha 2-adrenoceptor-deficient miceAnne Ulrike Trendelenburg
Institut fur Experimentelle und Klinische Pharmakologie und Toxikologie, Albertstrasse 25, D 79104 Freiburg i Br, Germany
Br J Pharmacol 138:1389-402. 2003..The results hence also suggest that in addition to alpha(2A)- and alpha(2C)- mouse postganglionic sympathetic neurons possess alpha(2B)-autoreceptors...
- Angiotensin II activates nuclear transcription factor-kappaB in aorta of normal rats and in vascular smooth muscle cells of AT1 knockout miceM Ruiz-Ortega
Laboratory of Vascular and Renal Pathology, , , Madrid, Spain
Nephrol Dial Transplant 16:27-33. 2001....
- Angiotensin receptors: form and function and distributionWalter G Thomas
Baker Heart Research Institute, University of Melbourne, P O Box 6492, St Kilda Road Central, Melbourne 8008, Vic, Australia
Int J Biochem Cell Biol 35:774-9. 2003The peptide hormone, angiotensin II, acts primarily via type I (AT(1)) and type II (AT(2)) angiotensin receptors. Proteolytic fragments of angiotensin II also have biological activity via these and other receptors, with actions that may ..
- Angiotensin-receptor blockade in acute myocardial infarction--a matter of doseDouglas L Mann
N Engl J Med 349:1963-5. 2003
- Angiotensin receptors--evolutionary overview and perspectivesH Nishimura
Department of Physiology, University of Tennessee Health Science Center, 894 Union Avenue, Memphis, TN 38163, USA
Comp Biochem Physiol A Mol Integr Physiol 128:11-30. 2001..Specific angiotensin receptors (AT receptors) that mediate important physiological functions have been noted in a variety of tissues and ..
- Postnatal hypoxemia increases angiotensin II sensitivity and up-regulates AT1a angiotensin receptors in rat carotid body chemoreceptors- M-L Fung
Department of Physiology, Faculty of Medicine, The University of Hong Kong, Hong Kong
J Endocrinol 173:305-13. 2002..This modulation may be important for adaptation of carotid body functions in the hypoxic ventilatory response and in electrolyte and water homeostasis during perinatal and postnatal hypoxia...
- Angiotensin receptors and agingRobert M Carey
Hypertension 50:33-4. 2007
- Estrogens contribute to a sex difference in plasma potassium concentration: a mechanism for regulation of adrenal angiotensin receptorsWei Zheng
Division of Nephrology and Hypertension, Georgetown University Medical Center, Washington, DC 20057, USA
Gend Med 3:43-53. 2006..Female sex steroids such as estrogen and progesterone are known modulators of the renin-angiotensin-aldosterone system...
- The growth-dependent expression of angiotensin II type 2 receptor is regulated by transcription factors interferon regulatory factor-1 and -2M Horiuchi
Division of Cardiovascular Medicine, Falk Cardiovascular Center, Stanford University School of Medicine, California 94305 5246, USA
J Biol Chem 270:20225-30. 1995..We speculate that these transcriptional factors influence cell growth in part by regulating AT2 receptor expression...
- Brain angiotensin receptors and binding proteinsRobert C Speth
Department of Pharmacology, Research Institute of Pharmaceutical Sciences, University of Mississippi, University, Oxford, MS 38677, USA
Naunyn Schmiedebergs Arch Pharmacol 377:283-93. 2008..g., stimulation of dopamine release from the striatum, as a peptidase, or as a clearance receptor, and the importance of the state of the internal environment of the brain to its function is reviewed...
- Angiotensin II increases intracellular calcium concentration in pig endometrial stromal cells through type 1 angiotensin receptors, but does not stimulate phospholipase C activity or prostaglandin F2alpha secretionGheorghe T Braileanu
Department of Animal Sciences, Washington State University, Pullman 99164 6353, USA
Reprod Fertil Dev 14:199-205. 2002....
- Mechanical stretch induces hypertrophic responses in cardiac myocytes of angiotensin II type 1a receptor knockout miceS Kudoh
Department of Cardiovascular Medicine, University of Tokyo School of Medicine, Tokyo 113 8655, Japan
J Biol Chem 273:24037-43. 1998..These results suggest that mechanical stretch could evoke hypertrophic responses in cardiac myocytes that lack the AT1 signaling pathway possibly through tyrosine kinase activation...
- Blockade of the renin-angiotensin system increases adiponectin concentrations in patients with essential hypertensionMasato Furuhashi
Second Department of Internal Medicine, Sapporo Medical University School of Medicine, S 1, W 16, Chuo Ku, Sapporo 060 8543, Japan
Hypertension 42:76-81. 2003..These results suggest that hypoadiponectinemia is related to insulin resistance in essential hypertension and that RAS blockade increases adiponectin concentrations with improvement in insulin sensitivity...
- Evidence that the angiotensin IV (AT(4)) receptor is the enzyme insulin-regulated aminopeptidaseA L Albiston
Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Victoria 3010, Australia
J Biol Chem 276:48623-6. 2001..We have therefore demonstrated that the AT(4) receptor is IRAP and propose that AT(4) receptor ligands may exert their effects by inhibiting the catalytic activity of IRAP thereby extending the half-life of its neuropeptide substrates...
- Effects of candesartan on mortality and morbidity in patients with chronic heart failure: the CHARM-Overall programmeMarc A Pfeffer
Cardiovascular Division, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
Lancet 362:759-66. 2003..Patients with chronic heart failure (CHF) are at high risk of cardiovascular death and recurrent hospital admissions. We aimed to find out whether the use of an angiotensin-receptor blocker could reduce mortality and morbidity...
- Cortical alterations of angiotensin converting enzyme, angiotensin II and AT1 receptor in Alzheimer's dementiaE Savaskan
Department of Psychiatry, University of Basel, Wilhelm Klein Str 27, CH 4054, Basel, Switzerland
Neurobiol Aging 22:541-6. 2001..In addition, a prominent perivascular ACE and angiotensin II immunoreactivity surrounding some cortical vessels in aged controls and AD patients points to an underlying microvascular pathology in the process of neurodegeneration...
- Efficacy and tolerability of a combination tablet of candesartan cilexetil and hydrochlorothiazide in insufficiently controlled primary hypertension--comparison with a combination of losartan and hydrochlorothiazideK P Ohma
Department of Medicine and Care, Faculty of Health Sciences, University Hospital, Linkoping, Sweden
Blood Press 9:214-20. 2000..The reduction in BP and the proportion of patients with normalized BP were greater with the candesartan/HCT 16/12.5 mg combination than with the losartan/ HCT 50/12.5 mg combination...
- Role of type 1 and type 2 angiotensin receptors in angiotensin II-induced cardiomyocyte hypertrophyG W Booz
Weis Center for Research, Geisinger Clinic, Danville, PA 17822, USA
Hypertension 28:635-40. 1996..These findings have potential clinical significance in that regression of hypertension-induced cardiac hypertrophy by AT1 antagonists may be in part due to an unopposed antigrowth effect of Ang II mediated via AT2...
- Genetic polymorphisms of the renin-angiotensin system and angiographic extent and severity of coronary artery disease: the CORGENE studyX Jeunemaitre
Laboratoire de Biologie Moleculaire, Ilôt des Mariniers, Assistance Publique Hopitaux de Paris, Hopital Broussais, France
Hum Genet 99:66-73. 1997..19, P = 0.04) in patients with low-risk status. These overall results are not in favor of a role of these RAS genetic polymorphisms in the development of coronary atherosclerosis...
- Angiotensin receptor agonistic autoantibodies induce pre-eclampsia in pregnant miceCissy C Zhou
Department of Biochemistry, University of Texas Houston Medical School, 6431 Fannin, Houston, Texas 77030, USA
Nat Med 14:855-62. 2008..This hypothesis has obvious implications regarding pre-eclampsia screening, diagnosis and therapy...
- Immunohistochemical detection of angiotensin receptors AT1 and AT2 in normal rat pituitary gland, estrogen-induced rat pituitary tumor and human pituitary adenomasMarek Pawlikowski
Department of Neuroendocrinology, Chair of Endocrinology, Medical University, Lodz, Poland
Folia Histochem Cytobiol 44:173-7. 2006..The expression of AT2 receptors, in turn, may be connected with the process of tumoral neo-angiogenesis...
- Use of angiotensin receptor blockers and risk of dementia in a predominantly male population: prospective cohort analysisNien Chen Li
Center for the Assessment of Pharmaceutical Practices and Pharmaceutical Assessment, Management and Policy Program, Department of Health Policy and Management, Boston University School of Public Health, Boston, MA 02118 2526, USA
BMJ 340:b5465. 2010..To investigate whether angiotensin receptor blockers protect against Alzheimer's disease and dementia or reduce the progression of both diseases...
- A population-based European cohort study of persistence in newly diagnosed hypertensive patientsJ Hasford
Department for Medical Informatics, Biometry and Epidemiology, University of Munich, Munich, Germany
J Hum Hypertens 16:569-75. 2002..Prescribing an antihypertensive agent that provides a favourable efficacy and tolerability profile may provide greater persistence with therapy and hence a higher level of blood pressure control...
- The brain angiotensin system and extracellular matrix molecules in neural plasticity, learning, and memoryJohn W Wright
Department of Psychology, Washington State University, P O Box 644820, Pullman, WA 99164 4820, USA
Prog Neurobiol 72:263-93. 2004....
- Protective role of the angiotensin AT2 receptor in a renal wrap hypertension modelH M Siragy
Department of Medicine, University of Virginia Health Sciences Center, Charlottesville, 22908, USA
Hypertension 33:1237-42. 1999....
- Metabolism alters the selectivity of angiotensin-(1-7) receptor ligands for angiotensin receptorsR K Handa
Department of Veterinary and Comparative Anatomy, College of Veterinary Medicine, Washington State University, Pullman 99164 6520, USA
J Am Soc Nephrol 11:1377-86. 2000....
- Differential expression of angiotensin receptor 1A and 1B in mouseJ M Burson
Department of Medicine, University of Iowa College of Medicine, Iowa City 52242
Am J Physiol 267:E260-7. 1994..Despite the high homology between the coding sequence of the AT1A and AT1B genes, they exhibit disparate tissue-specific expression profiles...
- Effects of candesartan in patients with chronic heart failure and reduced left-ventricular systolic function intolerant to angiotensin-converting-enzyme inhibitors: the CHARM-Alternative trialChristopher B Granger
Division of Cardiology, Duke University Medical Center, Durham, NC 27710, USA
Lancet 362:772-6. 2003..We aimed to find out whether candesartan, an angiotensin-receptor blocker, could improve outcome in such patients not taking an ACE inhibitor...
- Angiotensin receptors contribute to blood pressure homeostasis in salt-depleted SHRShigefumi Nakamura
Hypertension and Vascular Disease Center, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
Am J Physiol Regul Integr Comp Physiol 284:R164-73. 2003..Combined blockade of AT(2) and AT((1-7)) receptors and ANG II neutralization by the ANG II antibody reversed as much as 67% of the blood pressure-lowering effect of losartan...
- Retinal angiogenesis is mediated by an interaction between the angiotensin type 2 receptor, VEGF, and angiopoietinStella Sarlos
Department of Physiology, University of Melbourne, Parkville, Victoria, Australia
Am J Pathol 163:879-87. 2003..This study has identified a potential retinoprotective role for AT2-RB possibly mediated via interactions with VEGF- and angiopoietin-dependent pathways...
- Tissue-specific expression of human angiotensin II AT1 and AT2 receptors and cellular localization of subtype mRNAs in adult human renal cortex using in situ hybridizationH Matsubara
Department of Medicine II, Division of Endocrine Hypertension and Metabolism, Kansai Medical University, Osaka, Japan
Nephron 80:25-34. 1998....
- Angiotensin II angiogenic effect in vivo involves vascular endothelial growth factor- and inflammation-related pathwaysRadia Tamarat
INSERM U541, Hopital Lariboisiere, IFR Circulation Paris 7, Universite Paris 7 Denis Diderot, Paris, France
Lab Invest 82:747-56. 2002..Therefore, in an in vivo model, Ang II induced angiogenesis through AT1 receptor, which involved activation of VEGF/eNOS-related pathway and of the inflammatory process...
- Association of beta-Arrestin 1 with the type 1A angiotensin II receptor involves phosphorylation of the receptor carboxyl terminus and correlates with receptor internalizationH Qian
Molecular Endocrinology Laboratory, Baker Medical Research Institute, Melbourne 8008, Australia
Mol Endocrinol 15:1706-19. 2001....
- AT4 receptor is insulin-regulated membrane aminopeptidase: potential mechanisms of memory enhancementAnthony L Albiston
Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Parkville, VIC 3010, Australia
Trends Endocrinol Metab 14:72-7. 2003..Here, we explore the potential mechanisms by which Ang IV binding to IRAP leads to the facilitation of learning and memory...
- Cardiovascular morbidity and mortality in patients with diabetes in the Losartan Intervention For Endpoint reduction in hypertension study (LIFE): a randomised trial against atenololLars H Lindholm
Umea University Hospital, Sweden
Lancet 359:1004-10. 2002..In prespecified analyses, we compared the effects of losartan and atenolol on cardiovascular morbidity and mortality in diabetic patients...
- Side-chain substitutions within angiotensin II reveal different requirements for signaling, internalization, and phosphorylation of type 1A angiotensin receptorsAlice C Holloway
Molecular Endocrinology Laboratory, Baker Medical Research Institute, Melbourne, Australia
Mol Pharmacol 61:768-77. 2002..The requirements for AT(1A) receptor internalization seem to be less stringent than receptor activation and signaling, suggesting an inherent bias toward receptor deactivation...
- Left ventricular size, mass and function in relation to angiotensin-converting enzyme gene and angiotensin-II type 1 receptor gene polymorphisms in patients with coronary artery diseaseMarcin Gruchala
First Department of Cardiology Medical University of Gdansk, Gdansk, Poland
Clin Chem Lab Med 41:522-8. 2003..However, it indicates that the influence of polymorphisms may be present in specific patient populations...
- In vitro evidence for an intracellular site of angiotensin actionJ L Cook
Division of Research, Ochsner Clinic Foundation, New Orleans, LA, USA
Circ Res 89:1138-46. 2001....
- A randomized trial of the angiotensin-receptor blocker valsartan in chronic heart failureJ N Cohn
Department of Medicine, University of Minnesota Medical School, Minneapolis, 55455, USA
N Engl J Med 345:1667-75. 2001..However, the post hoc observation of an adverse effect on mortality and morbidity in the subgroup receiving valsartan, an ACE inhibitor, and a beta-blocker raises concern about the potential safety of this specific combination...
- Multiple actions of angiotensin II in hypertension: benefits of AT1 receptor blockadeErnesto L Schiffrin
J Am Coll Cardiol 42:911-3. 2003
- Rab5 association with the angiotensin II type 1A receptor promotes Rab5 GTP binding and vesicular fusionJennifer L Seachrist
John P Robarts Research Institute and Department of Pharmacology and Toxicology, University of Western Ontario, London, Ontario N6A 5K8, Canada
J Biol Chem 277:679-85. 2002....
- Microalbuminuria reduction with valsartan in patients with type 2 diabetes mellitus: a blood pressure-independent effectGiancarlo Viberti
Department of Diabetes, Endocrinology, and Internal Medicine, GKT School of Medicine, Guy s Hospital, King s College London, London, UK
Circulation 106:672-8. 2002..The MicroAlbuminuria Reduction With VALsartan (MARVAL) study was designed to evaluate the BP-independent effect of valsartan on UAER in type 2 diabetic patients with microalbuminuria...
- The novel G-protein coupled receptor SALPR shares sequence similarity with somatostatin and angiotensin receptorsM Matsumoto
Molecular Medicine Laboratories, Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co, Ltd, 21 Miyukigaoka, Tsukuba, Ibaraki, Japan
Gene 248:183-9. 2000..SALPR shares the highest amount of amino acid similarity with the somatostatin (35% with SSTR5) and angiotensin receptors (31% with AT1)...
- Restoration of cardiomyocyte functional properties by angiotensin II receptor blockade in diabetic ratsLaura Raimondi
Department of Preclinical and Clinical Pharmacology, Center of Molecular Medicine, University of Florence, Florence, Italy
Diabetes 53:1927-33. 2004..These data suggest that angiotensin receptor blockers may represent a new therapeutic strategy for diabetic cardiomyopathy...
- Newly emerging pharmacologic differences in angiotensin II receptor blockersS Oparil
University of Alabama at Birmingham, USA
Am J Hypertens 13:18S-24S. 2000....
- A comparison of the efficacy and duration of action of candesartan cilexetil and losartan as assessed by clinic and ambulatory blood pressure after a missed dose, in truly hypertensive patients: a placebo-controlled, forced titration study. Candesartan/LoY Lacourciere
Hypertension Research Unit, Centre hospitalier de l Universite Laval, Quebec, Canada
Am J Hypertens 12:1181-7. 1999..The differences observed between both agents are most likely attributable to a tighter binding to, and a slower dissociation from, the receptor binding site with candesartan cilexetil...
- A combination of a PPAR-gamma agonist and an angiotensin II receptor blocker attenuates proinflammatory signaling and stimulates expression of Smad7 in human peritoneal mesothelial cellsQ Yao
Department of Clinical Science, Intervention and Technology, Division of Baxter Novum, Karolinska Institute, Stockholm, Sweden
Clin Nephrol 68:295-301. 2007....
- Angiotensin II receptor blocker inhibits abnormal accumulation of advanced glycation end products and retinal damage in a rat model of type 2 diabetesTetsuya Sugiyama
Department of Ophthalmology, Osaka Medical College, Daigaku machi 2 7, Takatsuki, Osaka 569 8686, Japan
Exp Eye Res 85:406-12. 2007..Our findings indicate the ARB may inhibit the development of diabetic retinopathy by reducing the accumulation of pentosidine, one of AGEs and expression of VEGF in the retina...
- Angiotensin receptors: molecular biology and signallingT Inagami
Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
Clin Exp Pharmacol Physiol 26:544-9. 1999..5. Newer mechanisms and functions of these and other receptors will be clarified by the combination of molecular, cellular and integrated physiological studies...
- Differential expression of angiotensin receptors in human cutaneous wound healingU M Steckelings
Centre for Cardiovascular Research, Institute for Pharmacology and Toxicology, Charite Universitatsmedizin Berlin, Hessische Strasse 3 4, 10115 Berlin, Germany
Br J Dermatol 153:887-93. 2005..Angiotensin AT1 and AT2 receptors are expressed in human skin. Furthermore, AT2 receptors have been reported to be upregulated during tissue repair and remodelling in various noncutaneous human tissues...
- Molecular biology and signaling of angiotensin receptors: an overviewT Inagami
Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0146, USA
J Am Soc Nephrol 10:S2-7. 1999..Although AT1 works mainly through Gq/11 proteins, it has been shown that AT2 binds Gialpha2 and Gialpha3. However, the exact mechanisms of these actions are not clear and much work is required in many areas...
- Comparative efficacy of two angiotensin II receptor antagonists, irbesartan and losartan in mild-to-moderate hypertension. Irbesartan/Losartan Study InvestigatorsK Kassler-Taub
Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, New Jersey 08543-4000, USA
Am J Hypertens 11:445-53. 1998....
- In vivo inhibition of angiotensin receptors in the rat kidney by candesartan cilexetil: a comparison with losartanM E Fabiani
Department of Medicine, University of Melbourne, Austin and Repatriation Medical Centre, Heidelberg, Vic, Australia
Am J Hypertens 13:1005-13. 2000..Tissue blockade of Ang II receptors in target organs, such as the kidney, may contribute to the beneficial effects of Ang II receptor antagonists as antihypertensive agents...
- The reno-protective effect of the dual blockade of the renin angiotensin system (RAS)José Luño
Hospital General Universitario Gregorio Maranon, C Dr Esquerdo 46, 28007 Madrid, Spain
Curr Pharm Des 11:1291-300. 2005..Long-term clinical trials are needed and encouraged to further establish the significant role of dual blockade in renal protection particularly in diabetic nephropathy...
- Strain differences in the anxiolytic effects of losartan in the mouseP R Gard
School of Pharmacy and Biomolecular Sciences, University of Brighton, Moulsecoomb, BN2 4GJ, Brighton, UK
Pharmacol Biochem Behav 69:35-40. 2001....
- Angiotensin II type 2 receptor-mediated duodenal mucosal alkaline secretion in the ratB Johansson
Department of Physiology, , , Sweden
Am J Physiol Gastrointest Liver Physiol 280:G1254-60. 2001The aims of this study were to elucidate the distribution of angiotensin receptors (AT(1) and AT(2)) in the duodenal wall and to investigate whether AT(2) receptors are involved in the regulation of duodenal mucosal alkaline secretion, ..
- Comparative studies on the memory-enhancing actions of captopril and losartan in mice using inhibitory shock avoidance paradigmV Raghavendra
Pharmacology Division, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, India
Neuropeptides 35:65-9. 2001..However facilitation of acquisition only by captopril may be due to other putative mechanisms...
- Systemic infusion of angiotensin II into normal rats activates nuclear factor-kappaB and AP-1 in the kidney: role of AT(1) and AT(2) receptorsM Ruiz-Ortega
Laboratory of Vascular and Renal Pathology, Fundacion Jimenez Diaz, Universidad Autonoma, Madrid, Spain
Am J Pathol 158:1743-56. 2001..Our results provide novel information on AngII receptor signaling and support the recent view of Ang II as a proinflammatory modulator...
- Understanding/ Treating Neuropsychiatric Symptoms of Pediatric Physical IllnessEva Szigethy; Fiscal Year: 2009..abstract_text> ..
- Cholesterol and Lymphatic Transport of Molecules and CellsMelody A Swartz; Fiscal Year: 2012..Several promising tools that may ultimately lead to valuable insight into how lymphatic disorders could be treated will be explored in this proposal. ..
- Endogenous Aldosterone and Glucose HomeostasisJAMES MATTHEW LUTHER; Fiscal Year: 2013..In this proposal we will test the hypothesis that the endogenous RAAS impairs peripheral insulin sensitivity, hepatic insulin sensitivity, and insulin secretion in humans via aldosterone. ..
- Role of the Renin-Angiotensin system in placental insufficiencyEugenia Mata-Greenwood; Fiscal Year: 2013..In addition, the outcomes of this proposal will shed light into the role of RAS genetics in pregnancy outcomes and will provide the scientific community with a novel animal model to study the genetics of placental insufficiency and PE. ..
- Renal Angiotensin II Receptor Function in ObesityTahir Hussain; Fiscal Year: 2013..We propose to investigate the role of a novel target, namely the Angiotensin II AT2 receptor, to improve kidney function and lower blood pressure in an obesity/diabetic animal model. ..
- Roles for Phospholipase D2 in metabolism and cardiovascular homeostasisROCHELLE NELSON; Fiscal Year: 2013..These studies will also provide information necessary for new pharmacological targets aimed at the prevention of cardiovascular disease risk factors including hypertension and atherosclerosis. ..
- Human Aging, Exercise &FMD: Translational PhysiologyDouglas R Seals; Fiscal Year: 2013.._OVIDED. University of Colorado-Boulder, Boulder, Colorado ..
- Using Genetics For Early Phenotyping &Prevention of Hypertrophic CardiomyopathyChristine E Seidman; Fiscal Year: 2013..Early treatment can be targeted to at-risk, genetically susceptible individuals to offset the consequences of pathogenic mutations and prevent disease progression. ..
- POSTTRANSCRIPTIONAL REGULATION OF ANGIOTENSIN RECEPTORSKATHRYN L SANDBERG; Fiscal Year: 2011..These studies will determine the post-transcriptional mechanisms of AT1R regulation in these reciprocally regulated tissues and how these mechanisms are impaired in aged rats in response to altered sodium intake. ..
- Novel Formulation of Topical Losartan for Treatment of Wounds in AgingJEREMY DAVID WALSTON; Fiscal Year: 2013..on wound healing through Doppler and histological studies and through quantification and comparison of angiotensin receptors type 1 and 2 and TGF-[unreadable] protein and gene expression in wound tissue...
- AGE RELATED CHANGE IN ANGIOTENSIN RECEPTORS AND ITS ROLE IN CHRONIC INFLAMMATIONPeter M Abadir; Fiscal Year: 2013Project Abstract: Aging is associated with enhanced inflammation. An altered ratio between angiotensin receptors AT1R and AT2R results in induction of inflammation in animal models...
- HTS to identify chemical probes of the apelin receptor signaling pathwayLayton Harris Smith; Fiscal Year: 2010....
- Associations among RAAS Inhibitors, Residual Kidney Function, and CV Events in PDJenny I Shen; Fiscal Year: 2013..Further, the size of the database will allow us to study relevant patient subgroups. ..
- 2010 Angiotensin Gordon Research ConferenceKathy K Griendling; Fiscal Year: 2010..Of particular interest will be sessions detailing new data on the activation of angiotensin receptors by mechanical stretch and autoantibodies, the novel role of angiotensin in blood vessel development, ..
- Improving Methods for Comparative Effectiveness Research in Cardiovascular CareSOKO SETOGUCHI-IWATA; Fiscal Year: 2012..This award would play an important role in the applicant's development as an outstanding researcher who can provide leadership in CE research for CVD, especially in large database methods. ..
- Neonatal Growth and the Neurodevelopmental Origins of HypertensionRobert D Roghair; Fiscal Year: 2013....
- Identifying therapeutic targets for vulvodyniaPeter G Smith; Fiscal Year: 2013..Information obtained in these studies has strong potential to substantively change our thinking and clinical approach to the management of some forms of vulvodynia. ..
- Safety and Effectiveness Evaluations for Kidney Disease in Complex PatientsDONALD READ MILLER; Fiscal Year: 2010..This information should guide future prescribing practices and reduce the burden of this disease in our aging population. ..
- Brain specific non-AT1, non-AT2 angiotensin binding siteROBERT CHARLES SPETH; Fiscal Year: 2010..g., brain ischemia as in stroke, genetic or experimental hypertension and in transgenic mice lacking angiotensin receptors, can alter the expression of this binding site in specific brain regions...
- Dopamine and Angiotensin Receptor Interactions in Genetic HypertensionRobin A Felder; Fiscal Year: 2013..because of activating variants, directly causes the dysregulation of dopamine receptors, as well as the angiotensin receptors, in renal proximal tubule cells (RPTCs) from humans with essential hypertension...
- Pressure and Flow-Induced Remodeling of Coronary ArteriesGhassan S Kassab; Fiscal Year: 2010..There is no doubt that hemodynamic forces (blood pressure and blood flow) affect the angiotensin receptors and oxidative balance which lead to coronary artery disease (CAD)...
- Renal Dopamine and Angiotensin II Receptor Function in Age-Related HypertensionMohammad Asghar; Fiscal Year: 2013..These studies should provide a better understanding of the mechanism by which oxidative stress causes hypertension which would subsequently lead to targeted therapy for hypertension. ..
- Treatment of Kidney Disease in Diabetes and ObesityMoshe Levi; Fiscal Year: 2013..abstract_text> ..
- Angiotensin II Blockade for Chronic Allograft NephropathyHassan N Ibrahim; Fiscal Year: 2011..The drug being studied, Losartan, has proven efficacious in a number of kidney diseases. ..
- Role of angiotensin II receptor signaling pathways in body fluid homeostasisDerek Daniels; Fiscal Year: 2013..Understanding the neural mechanisms through which hormones mediate the ingestion of water, salt, and food may lead to novel therapeutic approaches to combat these relevant disease states. ..
- Central GRK5 modulation of Angiotensin II receptor expression in heart failureKARLA HAACK; Fiscal Year: 2013..We will also perform parallel studies using a K215R dominant negative GRK5 construct to determine if the GRK5/AT1R/I?B[unreadable]/NF-?B interaction is kinase-dependent. ..
- Consortium for Translational Research in Marfan SyndromeFRANCESCO B RAMIREZ; Fiscal Year: 2013..abstract_text> ..
- The Mas Receptor is Required for Angiotensin-(1-7) Effects in Cardiac RemodelingBarry H Greenberg; Fiscal Year: 2012..effects on cardiac fibroblast functions involved in remodeling require the Mas receptor, whether other angiotensin receptors mediate or influence these Ang-(1-7) effects and whether altering Mas expression in the post-MI heart ..
- ANGIOTENSIN RECEPTOR GENES AND BLOOD PRESSURE REGULATIONThomas M Coffman; Fiscal Year: 2010..of the renin-angiotensin system (RAS) to control blood pressure are primarily mediated by type I (ATd angiotensin receptors. In work done during the previous funding period using a kidney crosstransplantation model, we ..
- Pan-arterial insulin resistance - a target for clinical interventionEUGENE JOSEPH BARRETT; Fiscal Year: 2013....
- Human Cardiorenal SyndromeHorng H Chen; Fiscal Year: 2013..Aim 3: Define in hospitalized decompensated CHF patients with CRS, the renal actions of low dose intravenous infusion of BNP in the presence and absence of acute PDE V inhibition in improving renal function. ..
- Support for the recruit of a tenure track faculty member, Lie Gao, M.D., Ph.D.Irving H Zucker; Fiscal Year: 2010..His experiments will revolve around the area of the regulation of angiotensin receptors in the autonomic regulatory areas in the brain stem and hypothalamus...
- Central Angiotensin receptors and teh neural control of homeostasisERIC GERALD KRAUSE; Fiscal Year: 2013..These studies are designed to test the overall hypothesis that inhibition of AT1R in the brain will limit stress responding and alleviate the deleterious consequences of stress related illnesses. ..
- Impact of Comorbidity Dyads on Heart Failure Treatment in Older PersonsJerry H Gurwitz; Fiscal Year: 2013..abstract_text> ..
- A(1-7)-Mediated Mitigation of Radiation Induced ThrombocytopeniaKathleen E Rodgers; Fiscal Year: 2010..The first set of studies will establish alterations in angiotensin receptors expression by TBI with and without treatment with A(1-7)...
- Therapeutic Interventions during Acute Infection to Address the CNS Reservoir forSerena S Spudich; Fiscal Year: 2013..The knowledge gained will be critically relevant to the 40 million people worldwide living with HIV, informing novel strategies aimed at viral eradication of HIV and prevention of inflammation in the CNS. ..
- Impact of Puberty on the Kidney in DiabetesPASCALE LANE; Fiscal Year: 2005..Health implications: New treatments to prevent diabetic kidney disease, the most important cause of kidney failure in the US, may emerge from a better understanding of a naturally protected state such as the prepubertal animal. ..
- Regulation of NADPH Oxidase by Angiotensin II-Role in Myometrial HypertrophyXiaolan Cui; Fiscal Year: 2007..Excessive generation of reactive oxygen species contributes to contractile failure, rigor and calcium overload. Thus we predict that the angiotensin II-NADPH oxidase-reactive oxygen species pathway plays a role in labor process as well. ..
- REGULATION OF CARDIAC SECOND MESSENGERS BY ANGIOTENSINKenneth Baker; Fiscal Year: 1993..These studies will provide a more complete understanding of the role of angiotensin peptides in the modulation of cardiac function at the level of second messengers...
- Pirfenidone: Anti-Scarring Drug for Diabetic NephropathyKumar Sharma; Fiscal Year: 2005....
- Angiotensin II Receptor Blockade and Adipose Tissue Inflammation in ObesityKevin Davy; Fiscal Year: 2009..Importantly, these findings may lead to specific targets for therapy of adipose tissue inflammation, a factor linked to many obesity-related complications, and, in turn, improved outcomes for obese individuals. ..
- Estrogen/angiotensin receptors: normal & diabetic kidneySusan Mulroney; Fiscal Year: 2006..Understanding the sex-related mechanisms will help define specific therapeutic interventions. ..
- ANGIOTENSIN-II BLOCKADE IN MITRAL REGURGITATIONMaurice Enriquez Sarano; Fiscal Year: 2004..The results of this clinical trial should provide strong evidence regarding medical treatment of patients with organic MR and define future strategies to minimize mortality and morbidity of organic MR. ..
- Angiotensin II BlockadeHassan Ibrahim; Fiscal Year: 2007..These studies should help to describe the natural history, nature and pathogenesis of CAN,elucidate early markers and predictors of this important disorder and, perhaps, define a safe and useful preventative strategy. ..
- RENAL AT1A RECEPTORS AND REGULATION OF BLOOD PRESSUREMichael Oliverio; Fiscal Year: 1999..to changes in salt intake and volume status, DOCA salt, and by pharmacologic manipulation of other angiotensin receptors and vasoactive systems. Our second specific aim is to assess the role of renal AT1A receptors...
- ANGIOTENSIN EFFECTS IN HYPOTHALAMUS AND ADRENAL MEDULLAMarc Schiavone; Fiscal Year: 1993..Substantial evidence indicates: 1) that angiotensin receptors may be classified into two or more subtypes, and 2) that other angiotensin peptides in addition to Ang II ..
- The DASH-Sodium Trial: Genetic Determinants of ResponseLaura Svetkey; Fiscal Year: 2004..Ultimately, increased understanding of these mechanisms will lead to improved strategies for prevention and control, both nutritional and pharmacologic, of high BP. ..
- VASOACTIVE HORMONES: RECEPTORS AND SIGNALING MECHANISMUlrich Hopfer; Fiscal Year: 2004..three projects that are directed at gaining a better understanding of structural/functional aspects of angiotensin receptors and cellular signaling pathways with influences on cytoskeleton and ion transporters in kidney epithelium...
- ANGIOTENSIN II RECEPTOR SIGNALING DOMAINSRobert Wayne Alexander; Fiscal Year: 2010..These studies should provide new insights into the organization of Ang II signaling and identify potential new targets for novel therapeutic apporaches to cardiovascular diseases. ..
- PRIMARY AND SECONDARY PREVENTION OF CHD AND STROKESteven Ornstein; Fiscal Year: 2002..A formative evaluation of the interventions will be conducted. At the conclusion of the trial, the impact and cost of the intervention will be assessed. ..
- ATRIAL FIBRILLATION: MECHANISMS AND PREVENTIONMichael Rosen; Fiscal Year: 2003....
- Androgen Deficiency Due to Angiotensin II Blockade inCRFJOY LOGAN; Fiscal Year: 2006..However, the impact of these important drugs on androgens in men with CKD has not been well studied and needs clarification. ..
- HUMAN ANGIOTENSIN II RECEPTOR GENE REGULATIONTerry Elton; Fiscal Year: 2009..The knowledge gained from the proposed study may lead to the development of novel therapeutics for disease states in which aberrant regulation of hAT1 R expression occurs. ..
- SMALL ANIMAL ECHOCARDIOGRAPHY SYSTEMJohn Weil; Fiscal Year: 1999..date has encompassed studies of cardiac function in transgenic mice with knock-outs of creatine kinases, angiotensin receptors, and (with a hypertrophic cardiomyopathy phenotype); and in rats with increased ventricular afterload ..
- Role of Angiotensin Receptors in Experimental AAAJack Oak; Fiscal Year: 2004..Lastly, using gene-disrupted mice of either AT1 and AT2, we will see if aneurysm formation is attenuated in our mouse model. ..
- Overexpression of angiotensin receptors in HalobacteriaGEORGE TURNER; Fiscal Year: 2003..g. receptors and ion channels) and regulate their physiological responses accordingly. Angiotensin receptors are involved in an array of physiological processes including fetal kidney development, electrolyte ..
- CHRONIC NEURAL CONTROL OF BLOOD PRESSUREALAN SVED; Fiscal Year: 2007..In particular, blockade of AT1 angiotensin receptors in the RLVM decreases blood l pressure in SHR and Dahl salt-sensitive rats but not in normotensive rats...
- AT2 Receptor Modulates Renal Angiotensin II LevelsHelmy Siragy; Fiscal Year: 2005..Data obtained from this proposal will lead to increased understanding of the pathophysiology of hypertension and development of novel therapies for its management. ..
- LEVEL OF ACE INHIBITION IN HEART FAILUREUlrich Jorde; Fiscal Year: 2003..The proposal includes a two year formal training in methodology and ethics of clinical research already in place at AECOM. ..
- Angiotensin II Mediates Early Changes in Diabetic KidneyHelmy Siragy; Fiscal Year: 2007..The proposed studies will help understand the mechanisms that are involved in diabetic the development of new therapeutic modalities to prevent or slowdown the development ..
- Cytokine-induced Neurohumoral Excitation in Heart FailureJoseph Francis; Fiscal Year: 2009..The central link between cytokines and the neurohumoral system in HF may lead to a better understanding of the progression of the disease process and ultimately lead to new and effective strategies to treat HF. ..
- Significance of GPCR/JAK-STAT Coupling in the HeartCharlene McWhinney; Fiscal Year: 2003..abstract_text> ..
- ATHEROGENESIS AND THE BONE MARROW ANGIOTENSIN SYSTEMCarlos Ferrario; Fiscal Year: 2004..are: 1) the cells of the bone marrow produce renin, angiotensinogen, angiotensin-forming enzymes, and angiotensin receptors; 2) dyslipidemia increases bone marrow Ang II production; and 3) production of activated monocytic ..