angiotensin receptors

Summary

Summary: Cell surface proteins that bind ANGIOTENSINS and trigger intracellular changes influencing the behavior of cells.

Top Publications

  1. ncbi Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathy
    B M Brenner
    Renal Division, Brigham and Women s Hospital, Boston, MA 02115, USA
    N Engl J Med 345:861-9. 2001
  2. ncbi International union of pharmacology. XXIII. The angiotensin II receptors
    M De Gasparo
    Novartis Pharma AG, Metabolic and Cardiovascular Diseases, Basel, Switzerland
    Pharmacol Rev 52:415-72. 2000
  3. ncbi Renoprotective effect of the angiotensin-receptor antagonist irbesartan in patients with nephropathy due to type 2 diabetes
    E J Lewis
    Department of Medicine, Rush-Presbyterian-St Luke's Medical Center, Chicago, IL 60612, USA
    N Engl J Med 345:851-60. 2001
  4. ncbi Effects of different blood-pressure-lowering regimens on major cardiovascular events: results of prospectively-designed overviews of randomised trials
    Fiona Turnbull
    Blood Pressure Lowering Treatment Trialists Collaboration, The George Institute for International Health, University of Sydney, PO Box 576, Newtown, Sydney, New South Wales 2042, Australia
    Lancet 362:1527-35. 2003
  5. ncbi Cardiovascular morbidity and mortality in the Losartan Intervention For Endpoint reduction in hypertension study (LIFE): a randomised trial against atenolol
    Bjorn Dahlof
    Sahlgrenska University Hospital Ostra, Gothenburg, Swede
    Lancet 359:995-1003. 2002
  6. ncbi Drugs targeting the renin-angiotensin-aldosterone system
    Mohammad Amin Zaman
    Vascular Biology and Hypertension Program, Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Nat Rev Drug Discov 1:621-36. 2002
  7. ncbi The effect of irbesartan on the development of diabetic nephropathy in patients with type 2 diabetes
    H H Parving
    Steno Diabetes Center, Copenhagen, Denmark
    N Engl J Med 345:870-8. 2001
  8. ncbi Renoprotective properties of angiotensin receptor blockers beyond blood pressure lowering
    Yuko Izuhara
    Institute of Medical Sciences and Department of Internal Medicine, Tokai University School of Medicine, Kanagawa, Japan
    J Am Soc Nephrol 16:3631-41. 2005
  9. ncbi Angiotensin II and NGF differentially influence microtubule proteins in PC12W cells: role of the AT2 receptor
    U Stroth
    Department of Pharmacology, Christian Albrechts University, Hospitalstrasse 4, D 24105 Kiel, Germany
    Brain Res Mol Brain Res 53:187-95. 1998
  10. ncbi Angiotensin II stimulates endothelial vascular cell adhesion molecule-1 via nuclear factor-kappaB activation induced by intracellular oxidative stress
    M E Pueyo
    INSERM U460, Paris, France
    Arterioscler Thromb Vasc Biol 20:645-51. 2000

Detail Information

Publications256 found, 100 shown here

  1. ncbi Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathy
    B M Brenner
    Renal Division, Brigham and Women s Hospital, Boston, MA 02115, USA
    N Engl J Med 345:861-9. 2001
    ..We assessed the role of the angiotensin-II-receptor antagonist losartan in patients with type 2 diabetes and nephropathy...
  2. ncbi International union of pharmacology. XXIII. The angiotensin II receptors
    M De Gasparo
    Novartis Pharma AG, Metabolic and Cardiovascular Diseases, Basel, Switzerland
    Pharmacol Rev 52:415-72. 2000
    ..The development of specific nonpeptide receptor antagonists has led to major advances in the physiology, pharmacology, and therapy of the renin-angiotensin system...
  3. ncbi Renoprotective effect of the angiotensin-receptor antagonist irbesartan in patients with nephropathy due to type 2 diabetes
    E J Lewis
    Department of Medicine, Rush-Presbyterian-St Luke's Medical Center, Chicago, IL 60612, USA
    N Engl J Med 345:851-60. 2001
    ..CONCLUSIONS: The angiotensin-II-receptor blocker irbesartan is effective in protecting against the progression of nephropathy due to type 2 diabetes. This protection is independent of the reduction in blood pressure it causes...
  4. ncbi Effects of different blood-pressure-lowering regimens on major cardiovascular events: results of prospectively-designed overviews of randomised trials
    Fiona Turnbull
    Blood Pressure Lowering Treatment Trialists Collaboration, The George Institute for International Health, University of Sydney, PO Box 576, Newtown, Sydney, New South Wales 2042, Australia
    Lancet 362:1527-35. 2003
    ....
  5. ncbi Cardiovascular morbidity and mortality in the Losartan Intervention For Endpoint reduction in hypertension study (LIFE): a randomised trial against atenolol
    Bjorn Dahlof
    Sahlgrenska University Hospital Ostra, Gothenburg, Swede
    Lancet 359:995-1003. 2002
    ..We aimed to establish whether selective blocking of angiotensin II improves LVH beyond reducing blood pressure and, consequently, reduces cardiovascular morbidity and death...
  6. ncbi Drugs targeting the renin-angiotensin-aldosterone system
    Mohammad Amin Zaman
    Vascular Biology and Hypertension Program, Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Nat Rev Drug Discov 1:621-36. 2002
    ....
  7. ncbi The effect of irbesartan on the development of diabetic nephropathy in patients with type 2 diabetes
    H H Parving
    Steno Diabetes Center, Copenhagen, Denmark
    N Engl J Med 345:870-8. 2001
    ..02). CONCLUSIONS: Irbesartan is renoprotective independently of its blood-pressure-lowering effect in patients with type 2 diabetes and microalbuminuria...
  8. ncbi Renoprotective properties of angiotensin receptor blockers beyond blood pressure lowering
    Yuko Izuhara
    Institute of Medical Sciences and Department of Internal Medicine, Tokai University School of Medicine, Kanagawa, Japan
    J Am Soc Nephrol 16:3631-41. 2005
    ..These benefits of ARB may contribute to the renoprotection observed beyond BP lowering...
  9. ncbi Angiotensin II and NGF differentially influence microtubule proteins in PC12W cells: role of the AT2 receptor
    U Stroth
    Department of Pharmacology, Christian Albrechts University, Hospitalstrasse 4, D 24105 Kiel, Germany
    Brain Res Mol Brain Res 53:187-95. 1998
    ..These results implicate a specific role of AT2 receptors in cell differentiation and nerve regeneration via regulation of the cytoskeleton...
  10. ncbi Angiotensin II stimulates endothelial vascular cell adhesion molecule-1 via nuclear factor-kappaB activation induced by intracellular oxidative stress
    M E Pueyo
    INSERM U460, Paris, France
    Arterioscler Thromb Vasc Biol 20:645-51. 2000
    ..This activation enhances the expression of VCAM-1 and probably other genes involved in the early stages of atherosclerosis...
  11. ncbi The renin-angiotensin-aldosterone system and the kidney: effects on kidney disease
    Ursula C Brewster
    Section of Nephrology, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520 8029, USA
    Am J Med 116:263-72. 2004
    ....
  12. ncbi Angiotensin type 2 receptor dephosphorylates Bcl-2 by activating mitogen-activated protein kinase phosphatase-1 and induces apoptosis
    M Horiuchi
    Department of Medicine, Harvard Medical School, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Biol Chem 272:19022-6. 1997
    ..The AT2 receptor inhibits MAP kinase activation, resulting in the inactivation of Bcl-2 and the induction of apoptosis...
  13. ncbi Angiotensin receptors in the cardiovascular system
    Lodewijk J Wagenaar
    University of Groningen, The Netherlands
    Can J Cardiol 18:1331-9. 2002
    ..Four types of angiotensin receptors are known, of which the type 1 (AT1) and the type 2 (AT2) receptors are the most important...
  14. ncbi Olmesartan medoxomil, an angiotensin II receptor blocker ameliorates insulin resistance and decreases triglyceride production in fructose-fed rats
    Kenta Okada
    First Department of Internal Medicine, Showa University School of Medicine, Tokyo, Japan
    Hypertens Res 27:293-9. 2004
    ..Olmesartan ameliorates insulin resistance and overproduction of TG in fructose-fed rats, and these effects appear to be independent of its hypotensive action...
  15. ncbi The intracellular renin-angiotensin system: a new paradigm
    Rajesh Kumar
    Division of Molecular Cardiology, Cardiovascular Research Institute, Texas A and M Health Science Center, College of Medicine, Temple, TX 76508, USA
    Trends Endocrinol Metab 18:208-14. 2007
    ..A more comprehensive understanding of the intracellular RAS provides for new strategies in system regulation and a more efficacious approach to the management of RAS-related diseases...
  16. ncbi Distribution of type-1 and type-2 angiotensin receptors in the normal human lung and in lungs from patients with chronic obstructive pulmonary disease
    G R Bullock
    Department of Pathology, Blok A 503, University Hospital, De Pintelaan 185, 9000 Ghent, Belgium
    Histochem Cell Biol 115:117-24. 2001
    ..This correlated well with the reduced lung function as expressed by the forced expiratory volume...
  17. ncbi Angiotensin II type 1 receptor gene polymorphisms in human essential hypertension
    A Bonnardeaux
    INSERM U36, College de France, Paris
    Hypertension 24:63-9. 1994
    ..These findings would be compatible with a common variant of the AT1 receptor imparting a small effect on blood pressure; further studies will be needed to address this possibility...
  18. pmc Angiotensin II type 2 receptor mediates programmed cell death
    T Yamada
    Falk Cardiovascular Research Center, Stanford University School of Medicine, CA 94305 5246, USA
    Proc Natl Acad Sci U S A 93:156-60. 1996
    ..We hypothesize that this apoptotic function of the AT2 receptor may play an important role in developmental biology and pathophysiology...
  19. ncbi Emerging features of brain angiotensin receptors
    J M Saavedra
    Section on Pharmacology, National Institute of Mental Health, Bethesda, MD 20892, USA
    Regul Pept 85:31-45. 1999
    ....
  20. ncbi Valsartan, captopril, or both in myocardial infarction complicated by heart failure, left ventricular dysfunction, or both
    Marc A Pfeffer
    Cardiovascular Division, Brigham and Women s Hospital, Boston, MA 02115, USA
    N Engl J Med 349:1893-906. 2003
    ..In a double-blind trial, we compared the effect of the angiotensin-receptor blocker valsartan, the ACE inhibitor captopril, and the combination of the two on mortality in this population of patients...
  21. ncbi Angiotensin receptors in the nervous system
    A M Allen
    The Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Parkville, Victoria, Australia
    Brain Res Bull 47:17-28. 1998
    ..This review examines the distribution of these specific angiotensin receptors and discusses evidence regarding the function of angiotensin peptides in various brain regions...
  22. ncbi Renin-angiotensin system and cardiovascular risk
    Roland E Schmieder
    Department of Nephrology and Hypertension, University of Erlangen Nuremberg, 91054 Erlangen, Germany
    Lancet 369:1208-19. 2007
    ..Thus, blockade of this system will remain a cornerstone of our strategies to reduce cardiovascular risk...
  23. ncbi Molecular and cellular mechanisms of angiotensin II-mediated cardiovascular and renal diseases
    S Kim
    Department of Pharmacology, Osaka City University Medical School, Abeno Ku, Osaka, Japan
    Pharmacol Rev 52:11-34. 2000
    ..However, there are still unresolved questions and controversies on the mechanism of Ang II-mediated cardiovascular and renal diseases...
  24. ncbi Reduction of morbidity and mortality by statins, angiotensin-converting enzyme inhibitors, and angiotensin receptor blockers in patients with chronic obstructive pulmonary disease
    G B John Mancini
    Division of Cardiology, Vancouver Hospital, Jack Bell Research Centre, University of British Columbia, Vancouver, British Columbia, Canada
    J Am Coll Cardiol 47:2554-60. 2006
    ....
  25. ncbi Angiotensin receptors as determinants of life span
    Paola Cassis
    Mario Negri Institute for Pharmacological Research, Via Gavazzeni, 11, 24125 Bergamo, Italy
    Pflugers Arch 459:325-32. 2010
    ....
  26. pmc beta-Arrestin 1 and 2 differentially regulate heptahelical receptor signaling and trafficking
    T A Kohout
    Howard Hughes Medical Institute, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 98:1601-6. 2001
    ..These findings suggest that sequestration of various heptahelical receptors is regulated differently by the two beta-arrestins, whereas both isoforms are capable of supporting receptor desensitization and down-regulation...
  27. ncbi The renin-angiotensin-aldosterone system: a specific target for hypertension management
    M R Weir
    Department of Medicine, University of Maryland School of Medicine, Baltimore, USA
    Am J Hypertens 12:205S-213S. 1999
    ....
  28. ncbi Angiotensin II activates nuclear transcription factor-kappaB through AT1 and AT2 receptors
    Gunter Wolf
    Division of Nephrology and Osteology, Department of Medicine, University of Hamburg, Hamburg, Germany
    Kidney Int 61:1986-95. 2002
    ..We focused particularly on the Ang II subtype 2 (AT2) receptor because we previously observed that Ang II-induction of the chemokine RANTES in vitro and in vivo is mediated through AT2 receptors...
  29. ncbi Maternal undernutrition during early to midgestation programs tissue-specific alterations in the expression of the glucocorticoid receptor, 11beta-hydroxysteroid dehydrogenase isoforms, and type 1 angiotensin ii receptor in neonatal sheep
    C B Whorwood
    Endocrinology and Metabolism Unit, Division of the Fetal Origins of Adult Disease, School of Medicine, Southampton General Hospital, Southampton, United Kingdom SO16 6YD
    Endocrinology 142:2854-64. 2001
    ....
  30. ncbi The angiotensin AT4 receptor subtype as a target for the treatment of memory dysfunction associated with Alzheimer's disease
    John W Wright
    Department of Psychology, Veterinary and Comparative Anatomy, Pharmacology, and Physiology, Washington State University, P O Box 644820, Pullman, WA 99164 4820, USA
    J Renin Angiotensin Aldosterone Syst 9:226-37. 2008
    ..We conclude with a working hypothesis concerning the importance of the AT4 receptor subtype as a new potential drug target for the treatment of Alzheimer's disease-associated memory loss...
  31. ncbi New insights into the regulation of angiotensin receptors
    Masaki Mogi
    Department of Molecular Cardiovascular Biology and Pharmacology, Ehime University, Graduate School of Medicine, Shitsukawa, Tohon, Ehime, Japan
    Curr Opin Nephrol Hypertens 18:138-43. 2009
    ..These emerging concepts of regulation of Ang II receptors and a new insight into future drug discovery are discussed in this review...
  32. ncbi Cross-talk between AT(1) and AT(2) angiotensin receptors in rat anococcygeus smooth muscle
    Marcio A F de Godoy
    Department of Pharmacology, School of Medicine of Ribeirao Preto, University of Sao Paulo, Brazil
    J Pharmacol Exp Ther 303:333-9. 2002
    ..Results indicate the presence of a heterogeneous angiotensin receptor population in the rat anococcygeus muscle following a negative cross-talk relationship between the AT(1) and AT(2) subtypes...
  33. ncbi Angiotensin II subtype 2 receptor blockade and deficiency attenuate the development of atherosclerosis in an apolipoprotein E-deficient mouse model of diabetes
    A Koitka
    JDRF Danielle Alberti Memorial Centre for Diabetic Complications, Diabetes Division, Baker IDI Heart and Diabetes Research Institute, PO Box 6492, St Kilda Road Central, Melbourne, VIC 8008, Australia
    Diabetologia 53:584-92. 2010
    ..The aim of this study was to investigate the role of AT(2)R in diabetes-associated atherosclerosis using pharmacological blockade and genetic deficiency...
  34. ncbi Angiotensin II in cardiac pressure-overload hypertrophy in fetal sheep
    J L Segar
    Department of Pediatrics, University of Iowa, Iowa City, IA 52242, USA
    Am J Physiol Regul Integr Comp Physiol 281:R2037-47. 2001
    ..Elevated ANG II levels produce a selective increase in LV mass in the fetal sheep that is, in part, independent of increased systolic load...
  35. ncbi Effects of gestation on ovine fetal and maternal angiotensin receptor subtypes in the heart and major blood vessels
    J H Burrell
    School of Physiology and Pharmacology, University of New South Wales, Sydney 2052, Australia
    Exp Physiol 86:71-82. 2001
    ..Experimental Physiology (2001) 86.1, 71-82...
  36. ncbi Recent advances in angiotensin II signaling
    R M Touyz
    Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, University of Montreal, Quebec, Canada
    Braz J Med Biol Res 35:1001-15. 2002
    ....
  37. ncbi Control of dendritic cell differentiation by angiotensin II
    Karen A Nahmod
    Laboratory of Immunology, Institute of Hematologic Research, National Academy of Medicine, Buenos Aires, Argentina
    FASEB J 17:491-3. 2003
    ..Our results support the notion that the differentiation of DC is regulated by AII...
  38. pmc The angiotensin II type 2 (AT2) receptor promotes axonal regeneration in the optic nerve of adult rats
    R Lucius
    Institute of Anatomy, Christian Albrechts University Kiel, D 24105 Kiel, Germany
    J Exp Med 188:661-70. 1998
    ....
  39. ncbi Maternal autoantibodies from preeclamptic patients activate angiotensin receptors on human trophoblast cells
    Yang Xia
    Department of Biochemistry and Molecular Biology, Houston, Texas 77303, USA
    J Soc Gynecol Investig 10:82-93. 2003
    ..We sought to evaluate the role of AT1 agonistic autoantibodies (AT1-AA) in two major features of preeclampsia-increased plasminogen activator inhibitor-1 (PAI-1) production and shallow trophoblast invasion...
  40. ncbi Molecular cloning of AT1 angiotensin receptors
    T J Murphy
    Division of Cardiology, Emory University School of Medicine, Atlanta, GA 30322
    Am J Hypertens 5:236S-242S. 1992
    ..However, the tissue-specific expression pattern of the AT1b gene differs significantly from that for the AT1a receptor...
  41. pmc Sequential development of angiotensin receptors and angiotensin I converting enzyme during angiogenesis in the rat subcutaneous sponge granuloma
    D A Walsh
    Inflammation Group, London Hospital Medical College, Whitechapel
    Br J Pharmacol 120:1302-11. 1997
    ..Pharmacological modulation of this balance may provide novel therapeutic approaches in angiogenesis-dependent diseases...
  42. ncbi Angiotensin receptors: signaling, vascular pathophysiology, and interactions with ceramide
    C Berry
    Department of Medicine and Therapeutics, Western Infirmary, University of Glasgow, G11 6NT Glasgow, United Kingdom
    Am J Physiol Heart Circ Physiol 281:H2337-65. 2001
    ..This may be clinically relevant, inasmuch as inhibitors of the RAS are increasingly used in treatment of hypertension and coronary heart disease, where activation of the RAS is recognized...
  43. ncbi Agonistic and antagonistic properties of angiotensin analogs at the AT2 receptor in PC12W cells
    V Brechler
    Cardiovascular Research Department, Pharmaceuticals Division, Ciba Geigy Ltd, Basel, Switzerland
    Regul Pept 44:207-13. 1993
    ..We found CGP 42112 to behave as a full agonist in this system, whereas PD 123319 and Sar Ile angiotensin II act as antagonists. As expected, the AT1 antagonist losartan did not affect this response...
  44. pmc Crosstalk between presynaptic angiotensin receptors, bradykinin receptors and alpha 2-autoreceptors in sympathetic neurons: a study in alpha 2-adrenoceptor-deficient mice
    Anne Ulrike Trendelenburg
    Institut fur Experimentelle und Klinische Pharmakologie und Toxikologie, Albertstrasse 25, D 79104 Freiburg i Br, Germany
    Br J Pharmacol 138:1389-402. 2003
    ..The results hence also suggest that in addition to alpha(2A)- and alpha(2C)- mouse postganglionic sympathetic neurons possess alpha(2B)-autoreceptors...
  45. ncbi Angiotensin II activates nuclear transcription factor-kappaB in aorta of normal rats and in vascular smooth muscle cells of AT1 knockout mice
    M Ruiz-Ortega
    Laboratory of Vascular and Renal Pathology, , , Madrid, Spain
    Nephrol Dial Transplant 16:27-33. 2001
    ....
  46. ncbi Angiotensin receptors: form and function and distribution
    Walter G Thomas
    Baker Heart Research Institute, University of Melbourne, P O Box 6492, St Kilda Road Central, Melbourne 8008, Vic, Australia
    Int J Biochem Cell Biol 35:774-9. 2003
    The peptide hormone, angiotensin II, acts primarily via type I (AT(1)) and type II (AT(2)) angiotensin receptors. Proteolytic fragments of angiotensin II also have biological activity via these and other receptors, with actions that may ..
  47. ncbi Angiotensin-receptor blockade in acute myocardial infarction--a matter of dose
    Douglas L Mann
    N Engl J Med 349:1963-5. 2003
  48. ncbi Angiotensin receptors--evolutionary overview and perspectives
    H Nishimura
    Department of Physiology, University of Tennessee Health Science Center, 894 Union Avenue, Memphis, TN 38163, USA
    Comp Biochem Physiol A Mol Integr Physiol 128:11-30. 2001
    ..Specific angiotensin receptors (AT receptors) that mediate important physiological functions have been noted in a variety of tissues and ..
  49. ncbi Postnatal hypoxemia increases angiotensin II sensitivity and up-regulates AT1a angiotensin receptors in rat carotid body chemoreceptors
    - M-L Fung
    Department of Physiology, Faculty of Medicine, The University of Hong Kong, Hong Kong
    J Endocrinol 173:305-13. 2002
    ..This modulation may be important for adaptation of carotid body functions in the hypoxic ventilatory response and in electrolyte and water homeostasis during perinatal and postnatal hypoxia...
  50. ncbi Angiotensin receptors and aging
    Robert M Carey
    Hypertension 50:33-4. 2007
  51. ncbi Estrogens contribute to a sex difference in plasma potassium concentration: a mechanism for regulation of adrenal angiotensin receptors
    Wei Zheng
    Division of Nephrology and Hypertension, Georgetown University Medical Center, Washington, DC 20057, USA
    Gend Med 3:43-53. 2006
    ..Female sex steroids such as estrogen and progesterone are known modulators of the renin-angiotensin-aldosterone system...
  52. ncbi The growth-dependent expression of angiotensin II type 2 receptor is regulated by transcription factors interferon regulatory factor-1 and -2
    M Horiuchi
    Division of Cardiovascular Medicine, Falk Cardiovascular Center, Stanford University School of Medicine, California 94305 5246, USA
    J Biol Chem 270:20225-30. 1995
    ..We speculate that these transcriptional factors influence cell growth in part by regulating AT2 receptor expression...
  53. ncbi Brain angiotensin receptors and binding proteins
    Robert C Speth
    Department of Pharmacology, Research Institute of Pharmaceutical Sciences, University of Mississippi, University, Oxford, MS 38677, USA
    Naunyn Schmiedebergs Arch Pharmacol 377:283-93. 2008
    ..g., stimulation of dopamine release from the striatum, as a peptidase, or as a clearance receptor, and the importance of the state of the internal environment of the brain to its function is reviewed...
  54. ncbi Angiotensin II increases intracellular calcium concentration in pig endometrial stromal cells through type 1 angiotensin receptors, but does not stimulate phospholipase C activity or prostaglandin F2alpha secretion
    Gheorghe T Braileanu
    Department of Animal Sciences, Washington State University, Pullman 99164 6353, USA
    Reprod Fertil Dev 14:199-205. 2002
    ....
  55. ncbi Mechanical stretch induces hypertrophic responses in cardiac myocytes of angiotensin II type 1a receptor knockout mice
    S Kudoh
    Department of Cardiovascular Medicine, University of Tokyo School of Medicine, Tokyo 113 8655, Japan
    J Biol Chem 273:24037-43. 1998
    ..These results suggest that mechanical stretch could evoke hypertrophic responses in cardiac myocytes that lack the AT1 signaling pathway possibly through tyrosine kinase activation...
  56. ncbi Blockade of the renin-angiotensin system increases adiponectin concentrations in patients with essential hypertension
    Masato Furuhashi
    Second Department of Internal Medicine, Sapporo Medical University School of Medicine, S 1, W 16, Chuo Ku, Sapporo 060 8543, Japan
    Hypertension 42:76-81. 2003
    ..These results suggest that hypoadiponectinemia is related to insulin resistance in essential hypertension and that RAS blockade increases adiponectin concentrations with improvement in insulin sensitivity...
  57. ncbi Evidence that the angiotensin IV (AT(4)) receptor is the enzyme insulin-regulated aminopeptidase
    A L Albiston
    Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Victoria 3010, Australia
    J Biol Chem 276:48623-6. 2001
    ..We have therefore demonstrated that the AT(4) receptor is IRAP and propose that AT(4) receptor ligands may exert their effects by inhibiting the catalytic activity of IRAP thereby extending the half-life of its neuropeptide substrates...
  58. ncbi Effects of candesartan on mortality and morbidity in patients with chronic heart failure: the CHARM-Overall programme
    Marc A Pfeffer
    Cardiovascular Division, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Lancet 362:759-66. 2003
    ..Patients with chronic heart failure (CHF) are at high risk of cardiovascular death and recurrent hospital admissions. We aimed to find out whether the use of an angiotensin-receptor blocker could reduce mortality and morbidity...
  59. ncbi Cortical alterations of angiotensin converting enzyme, angiotensin II and AT1 receptor in Alzheimer's dementia
    E Savaskan
    Department of Psychiatry, University of Basel, Wilhelm Klein Str 27, CH 4054, Basel, Switzerland
    Neurobiol Aging 22:541-6. 2001
    ..In addition, a prominent perivascular ACE and angiotensin II immunoreactivity surrounding some cortical vessels in aged controls and AD patients points to an underlying microvascular pathology in the process of neurodegeneration...
  60. ncbi Efficacy and tolerability of a combination tablet of candesartan cilexetil and hydrochlorothiazide in insufficiently controlled primary hypertension--comparison with a combination of losartan and hydrochlorothiazide
    K P Ohma
    Department of Medicine and Care, Faculty of Health Sciences, University Hospital, Linkoping, Sweden
    Blood Press 9:214-20. 2000
    ..The reduction in BP and the proportion of patients with normalized BP were greater with the candesartan/HCT 16/12.5 mg combination than with the losartan/ HCT 50/12.5 mg combination...
  61. ncbi Role of type 1 and type 2 angiotensin receptors in angiotensin II-induced cardiomyocyte hypertrophy
    G W Booz
    Weis Center for Research, Geisinger Clinic, Danville, PA 17822, USA
    Hypertension 28:635-40. 1996
    ..These findings have potential clinical significance in that regression of hypertension-induced cardiac hypertrophy by AT1 antagonists may be in part due to an unopposed antigrowth effect of Ang II mediated via AT2...
  62. ncbi Genetic polymorphisms of the renin-angiotensin system and angiographic extent and severity of coronary artery disease: the CORGENE study
    X Jeunemaitre
    Laboratoire de Biologie Moleculaire, Ilôt des Mariniers, Assistance Publique Hopitaux de Paris, Hopital Broussais, France
    Hum Genet 99:66-73. 1997
    ..19, P = 0.04) in patients with low-risk status. These overall results are not in favor of a role of these RAS genetic polymorphisms in the development of coronary atherosclerosis...
  63. pmc Angiotensin receptor agonistic autoantibodies induce pre-eclampsia in pregnant mice
    Cissy C Zhou
    Department of Biochemistry, University of Texas Houston Medical School, 6431 Fannin, Houston, Texas 77030, USA
    Nat Med 14:855-62. 2008
    ..This hypothesis has obvious implications regarding pre-eclampsia screening, diagnosis and therapy...
  64. ncbi Immunohistochemical detection of angiotensin receptors AT1 and AT2 in normal rat pituitary gland, estrogen-induced rat pituitary tumor and human pituitary adenomas
    Marek Pawlikowski
    Department of Neuroendocrinology, Chair of Endocrinology, Medical University, Lodz, Poland
    Folia Histochem Cytobiol 44:173-7. 2006
    ..The expression of AT2 receptors, in turn, may be connected with the process of tumoral neo-angiogenesis...
  65. pmc Use of angiotensin receptor blockers and risk of dementia in a predominantly male population: prospective cohort analysis
    Nien Chen Li
    Center for the Assessment of Pharmaceutical Practices and Pharmaceutical Assessment, Management and Policy Program, Department of Health Policy and Management, Boston University School of Public Health, Boston, MA 02118 2526, USA
    BMJ 340:b5465. 2010
    ..To investigate whether angiotensin receptor blockers protect against Alzheimer's disease and dementia or reduce the progression of both diseases...
  66. ncbi A population-based European cohort study of persistence in newly diagnosed hypertensive patients
    J Hasford
    Department for Medical Informatics, Biometry and Epidemiology, University of Munich, Munich, Germany
    J Hum Hypertens 16:569-75. 2002
    ..Prescribing an antihypertensive agent that provides a favourable efficacy and tolerability profile may provide greater persistence with therapy and hence a higher level of blood pressure control...
  67. ncbi The brain angiotensin system and extracellular matrix molecules in neural plasticity, learning, and memory
    John W Wright
    Department of Psychology, Washington State University, P O Box 644820, Pullman, WA 99164 4820, USA
    Prog Neurobiol 72:263-93. 2004
    ....
  68. ncbi Protective role of the angiotensin AT2 receptor in a renal wrap hypertension model
    H M Siragy
    Department of Medicine, University of Virginia Health Sciences Center, Charlottesville, 22908, USA
    Hypertension 33:1237-42. 1999
    ....
  69. ncbi Metabolism alters the selectivity of angiotensin-(1-7) receptor ligands for angiotensin receptors
    R K Handa
    Department of Veterinary and Comparative Anatomy, College of Veterinary Medicine, Washington State University, Pullman 99164 6520, USA
    J Am Soc Nephrol 11:1377-86. 2000
    ....
  70. ncbi Differential expression of angiotensin receptor 1A and 1B in mouse
    J M Burson
    Department of Medicine, University of Iowa College of Medicine, Iowa City 52242
    Am J Physiol 267:E260-7. 1994
    ..Despite the high homology between the coding sequence of the AT1A and AT1B genes, they exhibit disparate tissue-specific expression profiles...
  71. ncbi Effects of candesartan in patients with chronic heart failure and reduced left-ventricular systolic function intolerant to angiotensin-converting-enzyme inhibitors: the CHARM-Alternative trial
    Christopher B Granger
    Division of Cardiology, Duke University Medical Center, Durham, NC 27710, USA
    Lancet 362:772-6. 2003
    ..We aimed to find out whether candesartan, an angiotensin-receptor blocker, could improve outcome in such patients not taking an ACE inhibitor...
  72. ncbi Angiotensin receptors contribute to blood pressure homeostasis in salt-depleted SHR
    Shigefumi Nakamura
    Hypertension and Vascular Disease Center, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Am J Physiol Regul Integr Comp Physiol 284:R164-73. 2003
    ..Combined blockade of AT(2) and AT((1-7)) receptors and ANG II neutralization by the ANG II antibody reversed as much as 67% of the blood pressure-lowering effect of losartan...
  73. pmc Retinal angiogenesis is mediated by an interaction between the angiotensin type 2 receptor, VEGF, and angiopoietin
    Stella Sarlos
    Department of Physiology, University of Melbourne, Parkville, Victoria, Australia
    Am J Pathol 163:879-87. 2003
    ..This study has identified a potential retinoprotective role for AT2-RB possibly mediated via interactions with VEGF- and angiopoietin-dependent pathways...
  74. ncbi Tissue-specific expression of human angiotensin II AT1 and AT2 receptors and cellular localization of subtype mRNAs in adult human renal cortex using in situ hybridization
    H Matsubara
    Department of Medicine II, Division of Endocrine Hypertension and Metabolism, Kansai Medical University, Osaka, Japan
    Nephron 80:25-34. 1998
    ....
  75. ncbi Angiotensin II angiogenic effect in vivo involves vascular endothelial growth factor- and inflammation-related pathways
    Radia Tamarat
    INSERM U541, Hopital Lariboisiere, IFR Circulation Paris 7, Universite Paris 7 Denis Diderot, Paris, France
    Lab Invest 82:747-56. 2002
    ..Therefore, in an in vivo model, Ang II induced angiogenesis through AT1 receptor, which involved activation of VEGF/eNOS-related pathway and of the inflammatory process...
  76. ncbi Association of beta-Arrestin 1 with the type 1A angiotensin II receptor involves phosphorylation of the receptor carboxyl terminus and correlates with receptor internalization
    H Qian
    Molecular Endocrinology Laboratory, Baker Medical Research Institute, Melbourne 8008, Australia
    Mol Endocrinol 15:1706-19. 2001
    ....
  77. ncbi AT4 receptor is insulin-regulated membrane aminopeptidase: potential mechanisms of memory enhancement
    Anthony L Albiston
    Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Parkville, VIC 3010, Australia
    Trends Endocrinol Metab 14:72-7. 2003
    ..Here, we explore the potential mechanisms by which Ang IV binding to IRAP leads to the facilitation of learning and memory...
  78. ncbi Cardiovascular morbidity and mortality in patients with diabetes in the Losartan Intervention For Endpoint reduction in hypertension study (LIFE): a randomised trial against atenolol
    Lars H Lindholm
    Umea University Hospital, Sweden
    Lancet 359:1004-10. 2002
    ..In prespecified analyses, we compared the effects of losartan and atenolol on cardiovascular morbidity and mortality in diabetic patients...
  79. ncbi Side-chain substitutions within angiotensin II reveal different requirements for signaling, internalization, and phosphorylation of type 1A angiotensin receptors
    Alice C Holloway
    Molecular Endocrinology Laboratory, Baker Medical Research Institute, Melbourne, Australia
    Mol Pharmacol 61:768-77. 2002
    ..The requirements for AT(1A) receptor internalization seem to be less stringent than receptor activation and signaling, suggesting an inherent bias toward receptor deactivation...
  80. ncbi Left ventricular size, mass and function in relation to angiotensin-converting enzyme gene and angiotensin-II type 1 receptor gene polymorphisms in patients with coronary artery disease
    Marcin Gruchala
    First Department of Cardiology Medical University of Gdansk, Gdansk, Poland
    Clin Chem Lab Med 41:522-8. 2003
    ..However, it indicates that the influence of polymorphisms may be present in specific patient populations...
  81. ncbi In vitro evidence for an intracellular site of angiotensin action
    J L Cook
    Division of Research, Ochsner Clinic Foundation, New Orleans, LA, USA
    Circ Res 89:1138-46. 2001
    ....
  82. ncbi A randomized trial of the angiotensin-receptor blocker valsartan in chronic heart failure
    J N Cohn
    Department of Medicine, University of Minnesota Medical School, Minneapolis, 55455, USA
    N Engl J Med 345:1667-75. 2001
    ..However, the post hoc observation of an adverse effect on mortality and morbidity in the subgroup receiving valsartan, an ACE inhibitor, and a beta-blocker raises concern about the potential safety of this specific combination...
  83. ncbi Multiple actions of angiotensin II in hypertension: benefits of AT1 receptor blockade
    Ernesto L Schiffrin
    J Am Coll Cardiol 42:911-3. 2003
  84. ncbi Rab5 association with the angiotensin II type 1A receptor promotes Rab5 GTP binding and vesicular fusion
    Jennifer L Seachrist
    John P Robarts Research Institute and Department of Pharmacology and Toxicology, University of Western Ontario, London, Ontario N6A 5K8, Canada
    J Biol Chem 277:679-85. 2002
    ....
  85. ncbi Microalbuminuria reduction with valsartan in patients with type 2 diabetes mellitus: a blood pressure-independent effect
    Giancarlo Viberti
    Department of Diabetes, Endocrinology, and Internal Medicine, GKT School of Medicine, Guy s Hospital, King s College London, London, UK
    Circulation 106:672-8. 2002
    ..The MicroAlbuminuria Reduction With VALsartan (MARVAL) study was designed to evaluate the BP-independent effect of valsartan on UAER in type 2 diabetic patients with microalbuminuria...
  86. ncbi The novel G-protein coupled receptor SALPR shares sequence similarity with somatostatin and angiotensin receptors
    M Matsumoto
    Molecular Medicine Laboratories, Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co, Ltd, 21 Miyukigaoka, Tsukuba, Ibaraki, Japan
    Gene 248:183-9. 2000
    ..SALPR shares the highest amount of amino acid similarity with the somatostatin (35% with SSTR5) and angiotensin receptors (31% with AT1)...
  87. ncbi Restoration of cardiomyocyte functional properties by angiotensin II receptor blockade in diabetic rats
    Laura Raimondi
    Department of Preclinical and Clinical Pharmacology, Center of Molecular Medicine, University of Florence, Florence, Italy
    Diabetes 53:1927-33. 2004
    ..These data suggest that angiotensin receptor blockers may represent a new therapeutic strategy for diabetic cardiomyopathy...
  88. ncbi Newly emerging pharmacologic differences in angiotensin II receptor blockers
    S Oparil
    University of Alabama at Birmingham, USA
    Am J Hypertens 13:18S-24S. 2000
    ....
  89. ncbi A comparison of the efficacy and duration of action of candesartan cilexetil and losartan as assessed by clinic and ambulatory blood pressure after a missed dose, in truly hypertensive patients: a placebo-controlled, forced titration study. Candesartan/Lo
    Y Lacourciere
    Hypertension Research Unit, Centre hospitalier de l Universite Laval, Quebec, Canada
    Am J Hypertens 12:1181-7. 1999
    ..The differences observed between both agents are most likely attributable to a tighter binding to, and a slower dissociation from, the receptor binding site with candesartan cilexetil...
  90. ncbi A combination of a PPAR-gamma agonist and an angiotensin II receptor blocker attenuates proinflammatory signaling and stimulates expression of Smad7 in human peritoneal mesothelial cells
    Q Yao
    Department of Clinical Science, Intervention and Technology, Division of Baxter Novum, Karolinska Institute, Stockholm, Sweden
    Clin Nephrol 68:295-301. 2007
    ....
  91. ncbi Angiotensin II receptor blocker inhibits abnormal accumulation of advanced glycation end products and retinal damage in a rat model of type 2 diabetes
    Tetsuya Sugiyama
    Department of Ophthalmology, Osaka Medical College, Daigaku machi 2 7, Takatsuki, Osaka 569 8686, Japan
    Exp Eye Res 85:406-12. 2007
    ..Our findings indicate the ARB may inhibit the development of diabetic retinopathy by reducing the accumulation of pentosidine, one of AGEs and expression of VEGF in the retina...
  92. ncbi Angiotensin receptors: molecular biology and signalling
    T Inagami
    Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Clin Exp Pharmacol Physiol 26:544-9. 1999
    ..5. Newer mechanisms and functions of these and other receptors will be clarified by the combination of molecular, cellular and integrated physiological studies...
  93. ncbi Differential expression of angiotensin receptors in human cutaneous wound healing
    U M Steckelings
    Centre for Cardiovascular Research, Institute for Pharmacology and Toxicology, Charite Universitatsmedizin Berlin, Hessische Strasse 3 4, 10115 Berlin, Germany
    Br J Dermatol 153:887-93. 2005
    ..Angiotensin AT1 and AT2 receptors are expressed in human skin. Furthermore, AT2 receptors have been reported to be upregulated during tissue repair and remodelling in various noncutaneous human tissues...
  94. ncbi Molecular biology and signaling of angiotensin receptors: an overview
    T Inagami
    Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0146, USA
    J Am Soc Nephrol 10:S2-7. 1999
    ..Although AT1 works mainly through Gq/11 proteins, it has been shown that AT2 binds Gialpha2 and Gialpha3. However, the exact mechanisms of these actions are not clear and much work is required in many areas...
  95. ncbi Comparative efficacy of two angiotensin II receptor antagonists, irbesartan and losartan in mild-to-moderate hypertension. Irbesartan/Losartan Study Investigators
    K Kassler-Taub
    Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, New Jersey 08543-4000, USA
    Am J Hypertens 11:445-53. 1998
    ....
  96. ncbi In vivo inhibition of angiotensin receptors in the rat kidney by candesartan cilexetil: a comparison with losartan
    M E Fabiani
    Department of Medicine, University of Melbourne, Austin and Repatriation Medical Centre, Heidelberg, Vic, Australia
    Am J Hypertens 13:1005-13. 2000
    ..Tissue blockade of Ang II receptors in target organs, such as the kidney, may contribute to the beneficial effects of Ang II receptor antagonists as antihypertensive agents...
  97. ncbi The reno-protective effect of the dual blockade of the renin angiotensin system (RAS)
    José Luño
    Hospital General Universitario Gregorio Maranon, C Dr Esquerdo 46, 28007 Madrid, Spain
    Curr Pharm Des 11:1291-300. 2005
    ..Long-term clinical trials are needed and encouraged to further establish the significant role of dual blockade in renal protection particularly in diabetic nephropathy...
  98. ncbi Strain differences in the anxiolytic effects of losartan in the mouse
    P R Gard
    School of Pharmacy and Biomolecular Sciences, University of Brighton, Moulsecoomb, BN2 4GJ, Brighton, UK
    Pharmacol Biochem Behav 69:35-40. 2001
    ....
  99. ncbi Angiotensin II type 2 receptor-mediated duodenal mucosal alkaline secretion in the rat
    B Johansson
    Department of Physiology, , , Sweden
    Am J Physiol Gastrointest Liver Physiol 280:G1254-60. 2001
    The aims of this study were to elucidate the distribution of angiotensin receptors (AT(1) and AT(2)) in the duodenal wall and to investigate whether AT(2) receptors are involved in the regulation of duodenal mucosal alkaline secretion, ..
  100. ncbi Comparative studies on the memory-enhancing actions of captopril and losartan in mice using inhibitory shock avoidance paradigm
    V Raghavendra
    Pharmacology Division, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, India
    Neuropeptides 35:65-9. 2001
    ..However facilitation of acquisition only by captopril may be due to other putative mechanisms...
  101. pmc Systemic infusion of angiotensin II into normal rats activates nuclear factor-kappaB and AP-1 in the kidney: role of AT(1) and AT(2) receptors
    M Ruiz-Ortega
    Laboratory of Vascular and Renal Pathology, Fundacion Jimenez Diaz, Universidad Autonoma, Madrid, Spain
    Am J Pathol 158:1743-56. 2001
    ..Our results provide novel information on AngII receptor signaling and support the recent view of Ang II as a proinflammatory modulator...

Research Grants63

  1. Understanding/ Treating Neuropsychiatric Symptoms of Pediatric Physical Illness
    Eva Szigethy; Fiscal Year: 2009
    ..abstract_text> ..
  2. Cholesterol and Lymphatic Transport of Molecules and Cells
    Melody A Swartz; Fiscal Year: 2012
    ..Several promising tools that may ultimately lead to valuable insight into how lymphatic disorders could be treated will be explored in this proposal. ..
  3. Endogenous Aldosterone and Glucose Homeostasis
    JAMES MATTHEW LUTHER; Fiscal Year: 2013
    ..In this proposal we will test the hypothesis that the endogenous RAAS impairs peripheral insulin sensitivity, hepatic insulin sensitivity, and insulin secretion in humans via aldosterone. ..
  4. Role of the Renin-Angiotensin system in placental insufficiency
    Eugenia Mata-Greenwood; Fiscal Year: 2013
    ..In addition, the outcomes of this proposal will shed light into the role of RAS genetics in pregnancy outcomes and will provide the scientific community with a novel animal model to study the genetics of placental insufficiency and PE. ..
  5. Renal Angiotensin II Receptor Function in Obesity
    Tahir Hussain; Fiscal Year: 2013
    ..We propose to investigate the role of a novel target, namely the Angiotensin II AT2 receptor, to improve kidney function and lower blood pressure in an obesity/diabetic animal model. ..
  6. Roles for Phospholipase D2 in metabolism and cardiovascular homeostasis
    ROCHELLE NELSON; Fiscal Year: 2013
    ..These studies will also provide information necessary for new pharmacological targets aimed at the prevention of cardiovascular disease risk factors including hypertension and atherosclerosis. ..
  7. Human Aging, Exercise &FMD: Translational Physiology
    Douglas R Seals; Fiscal Year: 2013
    .._OVIDED. University of Colorado-Boulder, Boulder, Colorado ..
  8. Using Genetics For Early Phenotyping &Prevention of Hypertrophic Cardiomyopathy
    Christine E Seidman; Fiscal Year: 2013
    ..Early treatment can be targeted to at-risk, genetically susceptible individuals to offset the consequences of pathogenic mutations and prevent disease progression. ..
  9. POSTTRANSCRIPTIONAL REGULATION OF ANGIOTENSIN RECEPTORS
    KATHRYN L SANDBERG; Fiscal Year: 2011
    ..These studies will determine the post-transcriptional mechanisms of AT1R regulation in these reciprocally regulated tissues and how these mechanisms are impaired in aged rats in response to altered sodium intake. ..
  10. Novel Formulation of Topical Losartan for Treatment of Wounds in Aging
    JEREMY DAVID WALSTON; Fiscal Year: 2013
    ..on wound healing through Doppler and histological studies and through quantification and comparison of angiotensin receptors type 1 and 2 and TGF-[unreadable] protein and gene expression in wound tissue...
  11. AGE RELATED CHANGE IN ANGIOTENSIN RECEPTORS AND ITS ROLE IN CHRONIC INFLAMMATION
    Peter M Abadir; Fiscal Year: 2013
    Project Abstract: Aging is associated with enhanced inflammation. An altered ratio between angiotensin receptors AT1R and AT2R results in induction of inflammation in animal models...
  12. HTS to identify chemical probes of the apelin receptor signaling pathway
    Layton Harris Smith; Fiscal Year: 2010
    ....
  13. Associations among RAAS Inhibitors, Residual Kidney Function, and CV Events in PD
    Jenny I Shen; Fiscal Year: 2013
    ..Further, the size of the database will allow us to study relevant patient subgroups. ..
  14. 2010 Angiotensin Gordon Research Conference
    Kathy K Griendling; Fiscal Year: 2010
    ..Of particular interest will be sessions detailing new data on the activation of angiotensin receptors by mechanical stretch and autoantibodies, the novel role of angiotensin in blood vessel development, ..
  15. Improving Methods for Comparative Effectiveness Research in Cardiovascular Care
    SOKO SETOGUCHI-IWATA; Fiscal Year: 2012
    ..This award would play an important role in the applicant's development as an outstanding researcher who can provide leadership in CE research for CVD, especially in large database methods. ..
  16. Neonatal Growth and the Neurodevelopmental Origins of Hypertension
    Robert D Roghair; Fiscal Year: 2013
    ....
  17. Identifying therapeutic targets for vulvodynia
    Peter G Smith; Fiscal Year: 2013
    ..Information obtained in these studies has strong potential to substantively change our thinking and clinical approach to the management of some forms of vulvodynia. ..
  18. Safety and Effectiveness Evaluations for Kidney Disease in Complex Patients
    DONALD READ MILLER; Fiscal Year: 2010
    ..This information should guide future prescribing practices and reduce the burden of this disease in our aging population. ..
  19. Brain specific non-AT1, non-AT2 angiotensin binding site
    ROBERT CHARLES SPETH; Fiscal Year: 2010
    ..g., brain ischemia as in stroke, genetic or experimental hypertension and in transgenic mice lacking angiotensin receptors, can alter the expression of this binding site in specific brain regions...
  20. Dopamine and Angiotensin Receptor Interactions in Genetic Hypertension
    Robin A Felder; Fiscal Year: 2013
    ..because of activating variants, directly causes the dysregulation of dopamine receptors, as well as the angiotensin receptors, in renal proximal tubule cells (RPTCs) from humans with essential hypertension...
  21. Pressure and Flow-Induced Remodeling of Coronary Arteries
    Ghassan S Kassab; Fiscal Year: 2010
    ..There is no doubt that hemodynamic forces (blood pressure and blood flow) affect the angiotensin receptors and oxidative balance which lead to coronary artery disease (CAD)...
  22. Renal Dopamine and Angiotensin II Receptor Function in Age-Related Hypertension
    Mohammad Asghar; Fiscal Year: 2013
    ..These studies should provide a better understanding of the mechanism by which oxidative stress causes hypertension which would subsequently lead to targeted therapy for hypertension. ..
  23. Treatment of Kidney Disease in Diabetes and Obesity
    Moshe Levi; Fiscal Year: 2013
    ..abstract_text> ..
  24. Angiotensin II Blockade for Chronic Allograft Nephropathy
    Hassan N Ibrahim; Fiscal Year: 2011
    ..The drug being studied, Losartan, has proven efficacious in a number of kidney diseases. ..
  25. Role of angiotensin II receptor signaling pathways in body fluid homeostasis
    Derek Daniels; Fiscal Year: 2013
    ..Understanding the neural mechanisms through which hormones mediate the ingestion of water, salt, and food may lead to novel therapeutic approaches to combat these relevant disease states. ..
  26. Central GRK5 modulation of Angiotensin II receptor expression in heart failure
    KARLA HAACK; Fiscal Year: 2013
    ..We will also perform parallel studies using a K215R dominant negative GRK5 construct to determine if the GRK5/AT1R/I?B[unreadable]/NF-?B interaction is kinase-dependent. ..
  27. Consortium for Translational Research in Marfan Syndrome
    FRANCESCO B RAMIREZ; Fiscal Year: 2013
    ..abstract_text> ..
  28. The Mas Receptor is Required for Angiotensin-(1-7) Effects in Cardiac Remodeling
    Barry H Greenberg; Fiscal Year: 2012
    ..effects on cardiac fibroblast functions involved in remodeling require the Mas receptor, whether other angiotensin receptors mediate or influence these Ang-(1-7) effects and whether altering Mas expression in the post-MI heart ..
  29. ANGIOTENSIN RECEPTOR GENES AND BLOOD PRESSURE REGULATION
    Thomas M Coffman; Fiscal Year: 2010
    ..of the renin-angiotensin system (RAS) to control blood pressure are primarily mediated by type I (ATd angiotensin receptors. In work done during the previous funding period using a kidney crosstransplantation model, we ..
  30. Pan-arterial insulin resistance - a target for clinical intervention
    EUGENE JOSEPH BARRETT; Fiscal Year: 2013
    ....
  31. Human Cardiorenal Syndrome
    Horng H Chen; Fiscal Year: 2013
    ..Aim 3: Define in hospitalized decompensated CHF patients with CRS, the renal actions of low dose intravenous infusion of BNP in the presence and absence of acute PDE V inhibition in improving renal function. ..
  32. Support for the recruit of a tenure track faculty member, Lie Gao, M.D., Ph.D.
    Irving H Zucker; Fiscal Year: 2010
    ..His experiments will revolve around the area of the regulation of angiotensin receptors in the autonomic regulatory areas in the brain stem and hypothalamus...
  33. Central Angiotensin receptors and teh neural control of homeostasis
    ERIC GERALD KRAUSE; Fiscal Year: 2013
    ..These studies are designed to test the overall hypothesis that inhibition of AT1R in the brain will limit stress responding and alleviate the deleterious consequences of stress related illnesses. ..
  34. Impact of Comorbidity Dyads on Heart Failure Treatment in Older Persons
    Jerry H Gurwitz; Fiscal Year: 2013
    ..abstract_text> ..
  35. A(1-7)-Mediated Mitigation of Radiation Induced Thrombocytopenia
    Kathleen E Rodgers; Fiscal Year: 2010
    ..The first set of studies will establish alterations in angiotensin receptors expression by TBI with and without treatment with A(1-7)...
  36. Therapeutic Interventions during Acute Infection to Address the CNS Reservoir for
    Serena S Spudich; Fiscal Year: 2013
    ..The knowledge gained will be critically relevant to the 40 million people worldwide living with HIV, informing novel strategies aimed at viral eradication of HIV and prevention of inflammation in the CNS. ..
  37. Impact of Puberty on the Kidney in Diabetes
    PASCALE LANE; Fiscal Year: 2005
    ..Health implications: New treatments to prevent diabetic kidney disease, the most important cause of kidney failure in the US, may emerge from a better understanding of a naturally protected state such as the prepubertal animal. ..
  38. Regulation of NADPH Oxidase by Angiotensin II-Role in Myometrial Hypertrophy
    Xiaolan Cui; Fiscal Year: 2007
    ..Excessive generation of reactive oxygen species contributes to contractile failure, rigor and calcium overload. Thus we predict that the angiotensin II-NADPH oxidase-reactive oxygen species pathway plays a role in labor process as well. ..
  39. REGULATION OF CARDIAC SECOND MESSENGERS BY ANGIOTENSIN
    Kenneth Baker; Fiscal Year: 1993
    ..These studies will provide a more complete understanding of the role of angiotensin peptides in the modulation of cardiac function at the level of second messengers...
  40. Pirfenidone: Anti-Scarring Drug for Diabetic Nephropathy
    Kumar Sharma; Fiscal Year: 2005
    ....
  41. Angiotensin II Receptor Blockade and Adipose Tissue Inflammation in Obesity
    Kevin Davy; Fiscal Year: 2009
    ..Importantly, these findings may lead to specific targets for therapy of adipose tissue inflammation, a factor linked to many obesity-related complications, and, in turn, improved outcomes for obese individuals. ..
  42. Estrogen/angiotensin receptors: normal & diabetic kidney
    Susan Mulroney; Fiscal Year: 2006
    ..Understanding the sex-related mechanisms will help define specific therapeutic interventions. ..
  43. ANGIOTENSIN-II BLOCKADE IN MITRAL REGURGITATION
    Maurice Enriquez Sarano; Fiscal Year: 2004
    ..The results of this clinical trial should provide strong evidence regarding medical treatment of patients with organic MR and define future strategies to minimize mortality and morbidity of organic MR. ..
  44. Angiotensin II Blockade
    Hassan Ibrahim; Fiscal Year: 2007
    ..These studies should help to describe the natural history, nature and pathogenesis of CAN,elucidate early markers and predictors of this important disorder and, perhaps, define a safe and useful preventative strategy. ..
  45. RENAL AT1A RECEPTORS AND REGULATION OF BLOOD PRESSURE
    Michael Oliverio; Fiscal Year: 1999
    ..to changes in salt intake and volume status, DOCA salt, and by pharmacologic manipulation of other angiotensin receptors and vasoactive systems. Our second specific aim is to assess the role of renal AT1A receptors...
  46. ANGIOTENSIN EFFECTS IN HYPOTHALAMUS AND ADRENAL MEDULLA
    Marc Schiavone; Fiscal Year: 1993
    ..Substantial evidence indicates: 1) that angiotensin receptors may be classified into two or more subtypes, and 2) that other angiotensin peptides in addition to Ang II ..
  47. The DASH-Sodium Trial: Genetic Determinants of Response
    Laura Svetkey; Fiscal Year: 2004
    ..Ultimately, increased understanding of these mechanisms will lead to improved strategies for prevention and control, both nutritional and pharmacologic, of high BP. ..
  48. VASOACTIVE HORMONES: RECEPTORS AND SIGNALING MECHANISM
    Ulrich Hopfer; Fiscal Year: 2004
    ..three projects that are directed at gaining a better understanding of structural/functional aspects of angiotensin receptors and cellular signaling pathways with influences on cytoskeleton and ion transporters in kidney epithelium...
  49. ANGIOTENSIN II RECEPTOR SIGNALING DOMAINS
    Robert Wayne Alexander; Fiscal Year: 2010
    ..These studies should provide new insights into the organization of Ang II signaling and identify potential new targets for novel therapeutic apporaches to cardiovascular diseases. ..
  50. PRIMARY AND SECONDARY PREVENTION OF CHD AND STROKE
    Steven Ornstein; Fiscal Year: 2002
    ..A formative evaluation of the interventions will be conducted. At the conclusion of the trial, the impact and cost of the intervention will be assessed. ..
  51. ATRIAL FIBRILLATION: MECHANISMS AND PREVENTION
    Michael Rosen; Fiscal Year: 2003
    ....
  52. Androgen Deficiency Due to Angiotensin II Blockade inCRF
    JOY LOGAN; Fiscal Year: 2006
    ..However, the impact of these important drugs on androgens in men with CKD has not been well studied and needs clarification. ..
  53. HUMAN ANGIOTENSIN II RECEPTOR GENE REGULATION
    Terry Elton; Fiscal Year: 2009
    ..The knowledge gained from the proposed study may lead to the development of novel therapeutics for disease states in which aberrant regulation of hAT1 R expression occurs. ..
  54. SMALL ANIMAL ECHOCARDIOGRAPHY SYSTEM
    John Weil; Fiscal Year: 1999
    ..date has encompassed studies of cardiac function in transgenic mice with knock-outs of creatine kinases, angiotensin receptors, and (with a hypertrophic cardiomyopathy phenotype); and in rats with increased ventricular afterload ..
  55. Role of Angiotensin Receptors in Experimental AAA
    Jack Oak; Fiscal Year: 2004
    ..Lastly, using gene-disrupted mice of either AT1 and AT2, we will see if aneurysm formation is attenuated in our mouse model. ..
  56. Overexpression of angiotensin receptors in Halobacteria
    GEORGE TURNER; Fiscal Year: 2003
    ..g. receptors and ion channels) and regulate their physiological responses accordingly. Angiotensin receptors are involved in an array of physiological processes including fetal kidney development, electrolyte ..
  57. CHRONIC NEURAL CONTROL OF BLOOD PRESSURE
    ALAN SVED; Fiscal Year: 2007
    ..In particular, blockade of AT1 angiotensin receptors in the RLVM decreases blood l pressure in SHR and Dahl salt-sensitive rats but not in normotensive rats...
  58. AT2 Receptor Modulates Renal Angiotensin II Levels
    Helmy Siragy; Fiscal Year: 2005
    ..Data obtained from this proposal will lead to increased understanding of the pathophysiology of hypertension and development of novel therapies for its management. ..
  59. LEVEL OF ACE INHIBITION IN HEART FAILURE
    Ulrich Jorde; Fiscal Year: 2003
    ..The proposal includes a two year formal training in methodology and ethics of clinical research already in place at AECOM. ..
  60. Angiotensin II Mediates Early Changes in Diabetic Kidney
    Helmy Siragy; Fiscal Year: 2007
    ..The proposed studies will help understand the mechanisms that are involved in diabetic the development of new therapeutic modalities to prevent or slowdown the development ..
  61. Cytokine-induced Neurohumoral Excitation in Heart Failure
    Joseph Francis; Fiscal Year: 2009
    ..The central link between cytokines and the neurohumoral system in HF may lead to a better understanding of the progression of the disease process and ultimately lead to new and effective strategies to treat HF. ..
  62. Significance of GPCR/JAK-STAT Coupling in the Heart
    Charlene McWhinney; Fiscal Year: 2003
    ..abstract_text> ..
  63. ATHEROGENESIS AND THE BONE MARROW ANGIOTENSIN SYSTEM
    Carlos Ferrario; Fiscal Year: 2004
    ..are: 1) the cells of the bone marrow produce renin, angiotensinogen, angiotensin-forming enzymes, and angiotensin receptors; 2) dyslipidemia increases bone marrow Ang II production; and 3) production of activated monocytic ..