cell surface receptors

Summary

Summary: Cell surface proteins that bind signalling molecules external to the cell with high affinity and convert this extracellular event into one or more intracellular signals that alter the behavior of the target cell (From Alberts, Molecular Biology of the Cell, 2nd ed, pp693-5). Cell surface receptors, unlike enzymes, do not chemically alter their ligands.

Top Publications

  1. ncbi Notch signaling: cell fate control and signal integration in development
    S Artavanis-Tsakonas
    Massachusetts General Hospital Cancer Center, Department of Cell Biology, Harvard Medical School, Building 149, 13th Street, Charlestown, MA 02129, USA
    Science 284:770-6. 1999
  2. ncbi A Toll-like receptor recognizes bacterial DNA
    H Hemmi
    Department of Host Defense, Research Institute for Microbial Diseases, Osaka University and Core Research for Evolutional Science and Technology, Japan Science and Technology Corporation, Suita
    Nature 408:740-5. 2000
  3. ncbi Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene
    A Poltorak
    Howard Hughes Medical Institute and the Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75235 9050, USA
    Science 282:2085-8. 1998
  4. ncbi Toll-like receptors
    Kiyoshi Takeda
    Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Suita Osaka 565 0871, Japan
    Annu Rev Immunol 21:335-76. 2003
  5. ncbi Innate immune recognition
    Charles A Janeway
    Section of Immunobiology and Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut 06520 8011, USA
    Annu Rev Immunol 20:197-216. 2002
  6. ncbi Toll-like receptors: critical proteins linking innate and acquired immunity
    S Akira
    Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Osaka 565 0871, Japan
    Nat Immunol 2:675-80. 2001
  7. ncbi The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5
    F Hayashi
    Department of Immunology, University of Washington, Seattle 98195, USA
    Nature 410:1099-103. 2001
  8. ncbi Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product
    K Hoshino
    Department of Biochemistry, Hyogo College of Medicine, Japan
    J Immunol 162:3749-52. 1999
  9. ncbi A human homologue of the Drosophila Toll protein signals activation of adaptive immunity
    R Medzhitov
    Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520 8011, USA
    Nature 388:394-7. 1997
  10. ncbi Toll-like receptors and innate immunity
    R Medzhitov
    Section of Immunobiology, Yale University School Medicine, and Howard Hughes Medical Institute, New Haven, Connecticut 06520, USA
    Nat Rev Immunol 1:135-45. 2001

Detail Information

Publications270 found, 100 shown here

  1. ncbi Notch signaling: cell fate control and signal integration in development
    S Artavanis-Tsakonas
    Massachusetts General Hospital Cancer Center, Department of Cell Biology, Harvard Medical School, Building 149, 13th Street, Charlestown, MA 02129, USA
    Science 284:770-6. 1999
    ..Notch activity affects the implementation of differentiation, proliferation, and apoptotic programs, providing a general developmental tool to influence organ formation and morphogenesis...
  2. ncbi A Toll-like receptor recognizes bacterial DNA
    H Hemmi
    Department of Host Defense, Research Institute for Microbial Diseases, Osaka University and Core Research for Evolutional Science and Technology, Japan Science and Technology Corporation, Suita
    Nature 408:740-5. 2000
    ..The in vivo CpG-DNA-mediated T-helper type-1 response was also abolished in TLR9-/- mice. Thus, vertebrate immune systems appear to have evolved a specific Toll-like receptor that distinguishes bacterial DNA from self-DNA...
  3. ncbi Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene
    A Poltorak
    Howard Hughes Medical Institute and the Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75235 9050, USA
    Science 282:2085-8. 1998
    ..Destructive mutations of Tlr4 predispose to the development of Gram-negative sepsis, leaving most aspects of immune function intact...
  4. ncbi Toll-like receptors
    Kiyoshi Takeda
    Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Suita Osaka 565 0871, Japan
    Annu Rev Immunol 21:335-76. 2003
    ..The TLR-induced inflammatory response is dependent on a common signaling pathway that is mediated by the adaptor molecule MyD88. However, there is evidence for additional pathways that mediate TLR ligand-specific biological responses...
  5. ncbi Innate immune recognition
    Charles A Janeway
    Section of Immunobiology and Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut 06520 8011, USA
    Annu Rev Immunol 20:197-216. 2002
    ..Thus, microbial recognition by Toll-like receptors helps to direct adaptive immune responses to antigens derived from microbial pathogens...
  6. ncbi Toll-like receptors: critical proteins linking innate and acquired immunity
    S Akira
    Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Osaka 565 0871, Japan
    Nat Immunol 2:675-80. 2001
    ..However, evidence is accumulating that the signaling pathways associated with each TLR are not identical and may, therefore, result in different biological responses...
  7. ncbi The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5
    F Hayashi
    Department of Immunology, University of Washington, Seattle 98195, USA
    Nature 410:1099-103. 2001
    ..Our data suggest that TLR5, a member of the evolutionarily conserved Toll-like receptor family, has evolved to permit mammals specifically to detect flagellated bacterial pathogens...
  8. ncbi Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product
    K Hoshino
    Department of Biochemistry, Hyogo College of Medicine, Japan
    J Immunol 162:3749-52. 1999
    ..Overexpression of wild-type TLR4 but not the mutant TLR4 from C3H/HeJ mice activated NF-kappaB. Taken together, the present study demonstrates that TLR4 is the gene product that regulates LPS response...
  9. ncbi A human homologue of the Drosophila Toll protein signals activation of adaptive immunity
    R Medzhitov
    Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520 8011, USA
    Nature 388:394-7. 1997
    ..1, which is required for the activation of naive T cells...
  10. ncbi Toll-like receptors and innate immunity
    R Medzhitov
    Section of Immunobiology, Yale University School Medicine, and Howard Hughes Medical Institute, New Haven, Connecticut 06520, USA
    Nat Rev Immunol 1:135-45. 2001
    ..Recognition of microbial products by Toll-like receptors expressed on dendritic cells triggers functional maturation of dendritic cells and leads to initiation of antigen-specific adaptive immune responses...
  11. ncbi Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components
    O Takeuchi
    Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Japan
    Immunity 11:443-51. 1999
    ..These results demonstrate that TLR2 and TLR4 recognize different bacterial cell wall components in vivo and TLR2 plays a major role in Gram-positive bacterial recognition...
  12. ncbi Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3
    L Alexopoulou
    Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut, 06520, USA
    Nature 413:732-8. 2001
    ..Moreover, poly(I:C) can induce activation of NF-kappaB and mitogen-activated protein (MAP) kinases independently of MyD88, and cause dendritic cells to mature...
  13. pmc Dendritic cells induce peripheral T cell unresponsiveness under steady state conditions in vivo
    D Hawiger
    Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10021, USA
    J Exp Med 194:769-79. 2001
    ..We conclude that in the absence of additional stimuli DCs induce transient antigen-specific T cell activation followed by T cell deletion and unresponsiveness...
  14. pmc Interleukin 4 potently enhances murine macrophage mannose receptor activity: a marker of alternative immunologic macrophage activation
    M Stein
    Sir William Dunn School of Pathology, Oxford, United Kingdom
    J Exp Med 176:287-92. 1992
    ....
  15. ncbi Seven-transmembrane receptors
    Kristen L Pierce
    The Howard Hughes Medical Institute and the Department of Medicine, Box 3821, Duke University Medical Center, Durham, North Carolina 27710, USA
    Nat Rev Mol Cell Biol 3:639-50. 2002
    ..Recent findings indicate that the classical models of G-protein coupling and activation of second-messenger-generating enzymes do not fully explain their remarkably diverse biological actions...
  16. pmc DC-SIGN (CD209) mediates dengue virus infection of human dendritic cells
    Boonrat Tassaneetrithep
    Division of Retrovirology, Walter Reed Army Institite of Research and Henry M Jackson Foundation for the Advancement of Military Medicine Diseases, Rockville, MD 20850, USA
    J Exp Med 197:823-9. 2003
    ..Viruses produced by dendritic cells are infectious for DC-SIGN- and L-SIGN-bearing THP-1 cells and other permissive cell lines. Therefore, DC-SIGN may be considered as a new target for designing therapies that block dengue infection...
  17. ncbi Identification of the haemoglobin scavenger receptor
    M Kristiansen
    Department of Medical Biochemistry, University of Aarhus, Denmark
    Nature 409:198-201. 2001
    ..Specific CD163-mediated endocytosis of haptoglobin-haemoglobin complexes is measurable in cells transfected with CD163 complementary DNA and in CD163-expressing myelo-monocytic lymphoma cells...
  18. pmc MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4
    R Shimazu
    Department of Immunology, Saga Medical School, Saga, Japan
    J Exp Med 189:1777-82. 1999
    ..MD-2 is thus a link between TLR4 and LPS signaling. Identification of this new receptor complex has potential implications for understanding host defense, as well as pathophysiologic, mechanisms...
  19. ncbi IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway
    Katherine A Fitzgerald
    Division of Infectious Disease and Immunology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Nat Immunol 4:491-6. 2003
    ..Thus, IKKepsilon and TBK1 have a pivotal role in coordinating the activation of IRF3 and NF-kappaB in the innate immune response...
  20. ncbi Lipid rafts and signal transduction
    K Simons
    Max Planck Institute for Molecular Cell Biology and Genetics, Pfotenhauerstrasse 110, D 01307 Dresden, Germany
    Nat Rev Mol Cell Biol 1:31-9. 2000
    ..Lipid rafts containing a given set of proteins can change their size and composition in response to intra- or extracellular stimuli. This favours specific protein-protein interactions, resulting in the activation of signalling cascades...
  21. ncbi Quantitative expression of toll-like receptor 1-10 mRNA in cellular subsets of human peripheral blood mononuclear cells and sensitivity to CpG oligodeoxynucleotides
    Veit Hornung
    Department of Internal Medicine, Division of Clinical Pharmacology, University of Munich, Munich, Germany
    J Immunol 168:4531-7. 2002
    ..In addition, selective regulation of TLR7 expression in PDC and B cells by CpG ODN revealed TLR7 as a candidate TLR potentially involved in modulating the recognition of CpG motifs...
  22. pmc Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened
    James K Chen
    Department of Molecular Biology and Genetics, Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Genes Dev 16:2743-8. 2002
    ..These observations reveal the mechanism of cyclopamine's teratogenic and antitumor activities and further suggest a role for small molecules in the physiological regulation of Smo...
  23. ncbi Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways
    Yifeng Zhang
    Howard Hughes Medical Institute, Department of Biology, University of California, San Diego, La Jolla, CA 92093, USA
    Cell 112:293-301. 2003
    ..Thus, bitter is encoded independently of sweet and amino acids, and taste receptor cells are not broadly tuned across these modalities...
  24. ncbi Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway
    Masahiro Yamamoto
    Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, 3 1 Yamada oka, Suita Osaka 565 0871, Japan
    Science 301:640-3. 2003
    ..These findings demonstrate that TRIF is essential for TLR3- and TLR4-mediated signaling pathways facilitating mammalian antiviral host defense...
  25. ncbi EIN2, a bifunctional transducer of ethylene and stress responses in Arabidopsis
    J M Alonso
    Plant Science Institute, Department of Biology, University of Pennsylvania, Philadelphia, PA 19104 6018, USA
    Science 284:2148-52. 1999
    ..EIN2 is thus recognized as a molecular link between previously distinct hormone response pathways. Plants may use a combinatorial mechanism for assessing various stresses by enlisting a common set of signaling molecules...
  26. pmc The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between toll-like receptors
    A Ozinsky
    Department of Immunology, University of Washington, H 574 Health Sciences, Box 357650, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 97:13766-71. 2000
    ....
  27. ncbi Crystal structure of rhodopsin: A G protein-coupled receptor
    K Palczewski
    Department of Ophthalmology, University of Washington, Seattle, WA 98195, USA
    Science 289:739-45. 2000
    ..Identification of a set of residues that mediate interactions between the transmembrane helices and the cytoplasmic surface, where G-protein activation occurs, also suggests a possible structural change upon photoactivation...
  28. ncbi Soluble endoglin and other circulating antiangiogenic factors in preeclampsia
    Richard J Levine
    Division of Epidemiology, Statistics, and Prevention Research, National Institute of Child Health and Human Development, Department of Health and Human Services, Bethesda, MD 20892, USA
    N Engl J Med 355:992-1005. 2006
    ..Since soluble endoglin, another antiangiogenic protein, acts together with sFlt1 to induce a severe preeclampsia-like syndrome in pregnant rats, we examined whether it is associated with preeclampsia in women...
  29. ncbi Human homolog of patched, a candidate gene for the basal cell nevus syndrome
    R L Johnson
    Department of Developmental Biology, Howard Hughes Medical Institute, Stanford University School of Medicine, California 94305 5427, USA
    Science 272:1668-71. 1996
    ..The human PTC gene appears to be crucial for proper embryonic development and for tumor suppression...
  30. ncbi Toll-like receptors in innate immunity
    Kiyoshi Takeda
    Department of Molecular Genetics, Medical Institute of Bioregulation, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Int Immunol 17:1-14. 2005
    ..The involvement of TLR-mediated pathways in autoimmune and inflammatory diseases has been proposed. Thus, TLR-mediated activation of innate immunity controls not only host defense against pathogens but also immune disorders...
  31. ncbi Toll-like receptors control activation of adaptive immune responses
    M Schnare
    Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Nat Immunol 2:947-50. 2001
    ..These results suggest that distinct pathways of the innate immune system control activation of the two effector arms of adaptive immunity...
  32. ncbi TLR9 signals after translocating from the ER to CpG DNA in the lysosome
    Eicke Latz
    Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Lazare Research Building 308, 364 Plantation Street, Worcester, MA 01605, USA
    Nat Immunol 5:190-8. 2004
    ..Our data indicate a previously unknown mechanism of cellular activation involving the recruitment of TLR9 from the ER to sites of CpG DNA uptake, where signal transduction is initiated...
  33. ncbi Regulation of scavenger receptor CD163 expression in human monocytes and macrophages by pro- and antiinflammatory stimuli
    C Buechler
    Institut fur Klinische Chemie und Laboratoriumsmedizin, Klinikum der Universitat Regensburg, Germany
    J Leukoc Biol 67:97-103. 2000
    ..This expression pattern implies a functional role of CD 163 in the antiinflammatory response of monocytes...
  34. ncbi Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8
    Florian Heil
    Institute of Medical Microbiology, Immunology and Hygiene, Technische Universitat Munchen, Trogerstr 9, D 81675 Munich, Germany
    Science 303:1526-9. 2004
    ..These data suggest that ssRNA represents a physiological ligand for TLR7 and TLR8...
  35. ncbi Identification and expression cloning of a leptin receptor, OB-R
    L A Tartaglia
    Millennium Pharmaceuticals, Incorporated, Cambridge, Massachusetts 02139, USA
    Cell 83:1263-71. 1995
    ..Genetic mapping of the gene encoding OB-R shows that it is within the 5.1 cM interval of mouse chromosome 4 that contains the db locus...
  36. pmc Small molecule modulation of Smoothened activity
    James K Chen
    Department of Molecular Biology and Genetics, Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 99:14071-6. 2002
    ..The mechanistic differences between the Smo antagonists may be useful in the therapeutic manipulation of Hh signaling...
  37. ncbi Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours
    David M Berman
    Department of Molecular Biology and Genetics and Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Nature 425:846-51. 2003
    ..Our results identify a group of common lethal malignancies in which Hh pathway activity, essential for tumour growth, is activated not by mutation but by ligand expression...
  38. pmc Oligosaccharides of Hyaluronan activate dendritic cells via toll-like receptor 4
    Christian Termeer
    Department of Dermatology, University of Freiburg, Freiburg D 79104, Germany
    J Exp Med 195:99-111. 2002
    ..In conclusion, this is the first report that polysaccharide degradation products of the extracellular matrix produced during inflammation might serve as an endogenous ligand for the TLR-4 complex on DCs...
  39. ncbi Activating Smoothened mutations in sporadic basal-cell carcinoma
    J Xie
    Department of Dermatology, San Francisco General Hospital, University of California, 94110, USA
    Nature 391:90-2. 1998
    ..These findings support the role of SMO as a signalling component of the SHH-receptor complex and provide direct evidence that mutated SMO can function as an oncogene in BCCs...
  40. ncbi Cell activation and apoptosis by bacterial lipoproteins through toll-like receptor-2
    A O Aliprantis
    Skirball Institute and Department of Microbiology, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
    Science 285:736-9. 1999
    ..Thus, hTLR2 is a molecular link between microbial products, apoptosis, and host defense mechanisms...
  41. ncbi uPAR: a versatile signalling orchestrator
    Francesco Blasi
    Department of Molecular Biology and Functional Genomics, DIBIT, Universita Vita Salute San Raffaele, Via Olgettina 58, 20132 Milano, Italy
    Nat Rev Mol Cell Biol 3:932-43. 2002
    ....
  42. ncbi Cloning of adiponectin receptors that mediate antidiabetic metabolic effects
    Toshimasa Yamauchi
    Department of Internal Medicine, Graduate School of Medicine, University of Tokyo, Tokyo 113 8655, Japan
    Nature 423:762-9. 2003
    ....
  43. ncbi Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome
    H Hahn
    Centre for Molecular and Cell Biology, University of Queensland, St Lucia, Australia
    Cell 85:841-51. 1996
    ..We propose that a reduction in expression of the patched gene can lead to the developmental abnormalities observed in the syndrome and that complete loss of patched function contributes to transformation of certain cell types...
  44. ncbi Recognition of pathogen-associated molecular patterns by TLR family
    Shizuo Akira
    Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, SORST of Japan Science and Technology Corporation, 3 1 Yamada oka, Suita, Osaka 565 0871, Japan
    Immunol Lett 85:85-95. 2003
    ..These results indicate that TLR3, TLR7 and TLR9 may play an important role in detecting and combating viral infections...
  45. ncbi The dorsoventral regulatory gene cassette spätzle/Toll/cactus controls the potent antifungal response in Drosophila adults
    B Lemaitre
    Institut de Biologie Moléculaire at Cellulaire, UPR 9022 du Centre National de la Recherche Scientifique, Strasbourg, France
    Cell 86:973-83. 1996
    ..Antibacterial genes are induced either by a distinct pathway involving the immune deficiency gene (imd) or by combined activation of both imd and dorsoventral pathways...
  46. ncbi Soluble endoglin contributes to the pathogenesis of preeclampsia
    Shivalingappa Venkatesha
    Center for Vascular Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, Boston, Massachusetts 02215, USA
    Nat Med 12:642-9. 2006
    ..Our results suggest that sEng may act in concert with sFlt1 to induce severe preeclampsia...
  47. ncbi Common mechanisms of nerve and blood vessel wiring
    Peter Carmeliet
    The Center for Transgene Technology and Gene Therapy CTG, Flanders Interuniversity Institute for Biotechnology VIB, University of Leuven, 3000 Leuven, Belgium
    Nature 436:193-200. 2005
    ..Parallels have also emerged between the actions of growth factors that direct angiogenic sprouting and those that regulate axon terminal arborization...
  48. pmc Efficient targeting of protein antigen to the dendritic cell receptor DEC-205 in the steady state leads to antigen presentation on major histocompatibility complex class I products and peripheral CD8+ T cell tolerance
    Laura Bonifaz
    Laboratory of Cellular Physiology and Immunology, The Rockefeller University, New York, NY 10021, USA
    J Exp Med 196:1627-38. 2002
    ..Therefore, DEC-205 provides an efficient receptor-based mechanism for DCs to process proteins for MHC class I presentation in vivo, leading to tolerance in the steady state and immunity after DC maturation...
  49. pmc Molecular tinkering of G protein-coupled receptors: an evolutionary success
    J Bockaert
    UPR CNRS 9023, CCIPE, 141 rue de la Cardonille, 34094 Montpellier Cedex 5, France
    EMBO J 18:1723-9. 1999
    ..Finally, some GPCRs are unfaithful to G proteins and interact directly, via their C-terminal domain, with proteins containing PDZ and Enabled/VASP homology (EVH)-like domains...
  50. ncbi Tolerogenic dendritic cells
    Ralph M Steinman
    Laboratory of Cellular Physiology and Immunology, The Rockefeller University, New York, New York 10021 6399, USA
    Annu Rev Immunol 21:685-711. 2003
    ..We suggest that several clinical situations, including autoimmunity and certain infectious diseases, can be influenced by the antigen-specific tolerogenic role of DCs...
  51. ncbi Essential role of MD-2 in LPS responsiveness and TLR4 distribution
    Yoshinori Nagai
    Division of Infectious Genetics, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    Nat Immunol 3:667-72. 2002
    ..Thus, MD-2 is essential for correct intracellular distribution and LPS-recognition of TLR4...
  52. pmc C-type lectins DC-SIGN and L-SIGN mediate cellular entry by Ebola virus in cis and in trans
    Carmen P Alvarez
    Laboratory of Molecular Microbiology, Dept of Microbiology, Hospital 12 de Octubre, 28041 Madrid, Spain
    J Virol 76:6841-4. 2002
    ..Our data underscore a role for DC-SIGN and L-SIGN in the infective process and pathogenicity of Ebola virus infection...
  53. ncbi Hedgehog signalling in prostate regeneration, neoplasia and metastasis
    Sunil S Karhadkar
    Department of Molecular Biology and Genetics and the Howard Hughes Medical Institute, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Nature 431:707-12. 2004
    ..Monitoring and manipulating Hh pathway activity may thus offer significant improvements in diagnosis and treatment of prostate cancers with metastatic potential...
  54. ncbi SLAM (CDw150) is a cellular receptor for measles virus
    H Tatsuo
    Department of Virology, Faculty of Medicine, Kyushu University, Fukuoka, Japan
    Nature 406:893-7. 2000
    ..The identification of SLAM as a receptor for measles virus opens the way to a better understanding of the pathogenesis of measles virus infection, especially the immunosuppression induced by measles virus...
  55. ncbi Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA
    Sandra S Diebold
    Immunobiology Laboratory, Cancer Research UK, London Research Institute, London WC2A 3PX, UK
    Science 303:1529-31. 2004
    ..These results identify ssRNA as a ligand for TLR7 and suggest that cells of the innate immune system sense endosomal ssRNA to detect infection by RNA viruses...
  56. ncbi IRAK-M is a negative regulator of Toll-like receptor signaling
    Koichi Kobayashi
    Section of Immunobiology, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06510, USA
    Cell 110:191-202. 2002
    ..Endotoxin tolerance, a protection mechanism against endotoxin shock, was significantly reduced in IRAK-M(-/-) cells. Thus, IRAK-M regulates TLR signaling and innate immune homeostasis...
  57. ncbi Endoglin, a TGF-beta binding protein of endothelial cells, is the gene for hereditary haemorrhagic telangiectasia type 1
    K A McAllister
    Department of Genetics, Duke University Medical Center, Durham, North Carolina 27710
    Nat Genet 8:345-51. 1994
    ..We have identified endoglin as the HHT gene mapping to 9q3 and have established HHT as the first human disease defined by a mutation in a member of the TGF-beta receptor complex...
  58. ncbi Ethylene responses are negatively regulated by a receptor gene family in Arabidopsis thaliana
    J Hua
    Division of Biology, California Institute of Technology, Pasadena 91125, USA
    Cell 94:261-71. 1998
    ....
  59. ncbi The receptor DEC-205 expressed by dendritic cells and thymic epithelial cells is involved in antigen processing
    W Jiang
    Laboratory of Molecular Immunology, Rockefeller University, New York, New York 10021, USA
    Nature 375:151-5. 1995
    ..Thus DEC-205 is a novel endocytic receptor that can be used by dendritic cells and thymic epithelial cells to direct captured antigens from the extracellular space to a specialized antigen-processing compartment...
  60. ncbi Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4
    Masahiro Yamamoto
    Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Japan Science and Technology Corporation, 3 1 Yamada oka, Suita, Osaka 565 0871, Japan
    Nature 420:324-9. 2002
    ..Instead, TIRAP has a crucial role in the MyD88-dependent signalling pathway shared by TLR2 and TLR4...
  61. ncbi The Toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens
    D M Underhill
    Department of Immunology, University of Washington, Seattle 98195, USA
    Nature 401:811-5. 1999
    ....
  62. pmc Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin
    Genevieve Nguyen
    Institut National de la Santé et de la Recherche Médicale INSERM U489, and Association Claude Bernard, Hopital Tenon, Paris, France
    J Clin Invest 109:1417-27. 2002
    ..This discovery emphasizes the role of the cell surface in angiotensin II generation and opens new perspectives on the tissue renin-angiotensin system and on renin effects independent of angiotensin II...
  63. pmc Endotoxin-tolerant mice have mutations in Toll-like receptor 4 (Tlr4)
    S T Qureshi
    Department of Medicine, McGill University, Montreal, Quebec, Canada H3G 1A4
    J Exp Med 189:615-25. 1999
    ..Identification of distinct mutations involving the same gene at the Lps locus in two different hyporesponsive inbred mouse strains strongly supports the hypothesis that altered Tlr4 function is responsible for endotoxin tolerance...
  64. ncbi The Hedgehog response network: sensors, switches, and routers
    Lawrence Lum
    Department of Molecular Biology and Genetics, Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Science 304:1755-9. 2004
    ....
  65. ncbi Toll-like receptor 4 polymorphisms and atherogenesis
    Stefan Kiechl
    Department of Neurology, University Clinic, Innsbruck, Austria
    N Engl J Med 347:185-92. 2002
    ..We determined whether recently discovered genetic variants of toll-like receptor 4 (TLR4) that confer differences in the inflammatory response elicited by bacterial lipopolysaccharide are related to the development of atherosclerosis...
  66. pmc Mycobacteria target DC-SIGN to suppress dendritic cell function
    Teunis B H Geijtenbeek
    Department of Molecular Cell Biology, Vrije Universiteit Medical Center Amsterdam, 1081 BT Amsterdam, Netherlands
    J Exp Med 197:7-17. 2003
    ..Moreover, we demonstrate that DC-SIGN has a broader pathogen recognition profile than previously shown, suggesting that DC-SIGN may represent a molecular target for clinical intervention in infections other than HIV-1...
  67. ncbi Annexin I is an endogenous ligand that mediates apoptotic cell engulfment
    Swathi Arur
    Center for Vascular Biology, Department of Physiology, University of Connecticut School of Medicine, 263 Farmington Avenue, Farmington, CT 06030, USA
    Dev Cell 4:587-98. 2003
    ..These results provide novel mechanistic insights into how apoptotic cells are removed and may explain a pathogenic mechanism of chronic inflammatory diseases where annexin I autoantibodies have been described...
  68. ncbi Lipopolysaccharide stimulates the MyD88-independent pathway and results in activation of IFN-regulatory factor 3 and the expression of a subset of lipopolysaccharide-inducible genes
    T Kawai
    Department of Host Defense, Research Institute for Microbial Diseases, Japan Science and Technology Corporation, Osaka University, Osaka, Japan
    J Immunol 167:5887-94. 2001
    ....
  69. ncbi Cutting edge: TLR2-deficient and MyD88-deficient mice are highly susceptible to Staphylococcus aureus infection
    O Takeuchi
    Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan Core Research for Evolutional Science and Technology of Japan Science and Technology Corporation, Osaka, Japan
    J Immunol 165:5392-6. 2000
    ..aureus is recognized not only by TLR2, but also by other TLR family members except for TLR4...
  70. ncbi Biochemical and functional analysis of CTR1, a protein kinase that negatively regulates ethylene signaling in Arabidopsis
    Yafan Huang
    Department of Biological Sciences, University of Illinois at Chicago, Chicago, IL 60607, USA
    Plant J 33:221-33. 2003
    ..These results suggest that CTR1 interacts with ETR1 in vivo, and that this association is required to turn off the ethylene-signaling pathway...
  71. pmc In vivo depletion of CD11c+ dendritic cells abrogates priming of CD8+ T cells by exogenous cell-associated antigens
    Steffen Jung
    Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York 10016, USA
    Immunity 17:211-20. 2002
    ..e., the sensitization of the immune system for cell-associated antigens. DC-depleted mice fail to mount CTL responses to infection with the intracellular bacterium Listeria monocytogenes and the rodent malaria parasite Plasmodium yoelii...
  72. ncbi Endoglin is a component of the transforming growth factor-beta receptor system in human endothelial cells
    S Cheifetz
    Cell Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021
    J Biol Chem 267:19027-30. 1992
    ..TGF-beta however is binding with high affinity to only a small fraction of the available endoglin molecules, suggesting that some rate-limiting event is required to sustain TGF-beta binding to endoglin...
  73. pmc In vivo targeting of antigens to maturing dendritic cells via the DEC-205 receptor improves T cell vaccination
    Laura C Bonifaz
    Laboratory of Cellular Physiology and Immunology, Chris Browne Center for Immunology and Immune Diseases, The Rockefeller University, New York, NY 10021, USA
    J Exp Med 199:815-24. 2004
    ....
  74. ncbi IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines
    Jochen Schmitz
    Schering Plough Biopharma Formerly DNAX Research, Inc, 901 California Avenue, Palo Alto, California 94304, USA
    Immunity 23:479-90. 2005
    ..In vivo, IL-33 induces the expression of IL-4, IL-5, and IL-13 and leads to severe pathological changes in mucosal organs...
  75. ncbi TLR4 mutations are associated with endotoxin hyporesponsiveness in humans
    N C Arbour
    1 Department of Medicine, Department of Veterans Affairs Medical Center, The University of Iowa, Iowa City, Iowa, USA
    Nat Genet 25:187-91. 2000
    ....
  76. pmc Recognition of single-stranded RNA viruses by Toll-like receptor 7
    Jennifer M Lund
    Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 101:5598-603. 2004
    ..These results demonstrate microbial ligand recognition by TLR7 and provide insights into the pathways used by the innate immune cells in the recognition of viral pathogens...
  77. ncbi Defective angiogenesis in mice lacking endoglin
    D Y Li
    Program in Human Molecular Biology and Genetics, Department of Human Genetics, Howard Hughes Medical Institute, University of Utah, Salt Lake City, UT 84112 5330, USA
    Science 284:1534-7. 1999
    ..Loss of endoglin caused poor vascular smooth muscle development and arrested endothelial remodeling. These results demonstrate that endoglin is essential for angiogenesis and suggest a pathogenic mechanism for HHT1...
  78. ncbi Structural basis for signal transduction by the Toll/interleukin-1 receptor domains
    Y Xu
    Department of Biological Sciences, Columbia University, New York, New York 10027, USA
    Nature 408:111-5. 2000
    ....
  79. ncbi C-type lectin DC-SIGN modulates Toll-like receptor signaling via Raf-1 kinase-dependent acetylation of transcription factor NF-kappaB
    Sonja I Gringhuis
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, 1007 MB Amsterdam, The Netherlands
    Immunity 26:605-16. 2007
    ..Thus, this pathway is involved in regulation of adaptive immunity by DCs to bacterial, fungal, and viral pathogens...
  80. ncbi mRNA is an endogenous ligand for Toll-like receptor 3
    Katalin Kariko
    Division of Neurosurgery and Infectious Diseases, University of Pennsylvania, 3610 Hamilton Walk, Philadelphia, PA 19104, USA
    J Biol Chem 279:12542-50. 2004
    ..This finding has potential physiologic relevance because RNA escaping from damaged tissue or contained within endocytosed cells could serve as an endogenous ligand for TLR3 that induces or otherwise modulates immune responses...
  81. ncbi Uncovering molecular mechanisms involved in activation of G protein-coupled receptors
    U Gether
    Department of Medical Physiology, Panum Institute, University of Copenhagen, Denmark
    Endocr Rev 21:90-113. 2000
    ....
  82. pmc Tumors induce a subset of inflammatory monocytes with immunosuppressive activity on CD8+ T cells
    Giovanna Gallina
    Istituto Oncologico Veneto, Padua, Italy
    J Clin Invest 116:2777-90. 2006
    ..Moreover, our data show how the inflammatory response elicited by tumors had detrimental effects on the adaptive immune system and suggest novel approaches for the treatment of tumor-induced immune dysfunctions...
  83. ncbi Tolerization of dendritic cells by T(S) cells: the crucial role of inhibitory receptors ILT3 and ILT4
    C C Chang
    Department of Pathology, Columbia University, New York, NY 10032, USA
    Nat Immunol 3:237-43. 2002
    ..These findings demonstrate an important mechanism of immune regulation...
  84. pmc Collaborative induction of inflammatory responses by dectin-1 and Toll-like receptor 2
    Benjamin N Gantner
    Department of Immunology, University of Washington, Seattle, 98103, USA
    J Exp Med 197:1107-17. 2003
    ..The data demonstrate that collaborative recognition of distinct microbial components by different classes of innate immune receptors is crucial in orchestrating inflammatory responses...
  85. ncbi Role of the matrix metalloproteinase and plasminogen activator-plasmin systems in angiogenesis
    M S Pepper
    Department of Morphology, University Medical Center, Geneva, Switzerland
    Arterioscler Thromb Vasc Biol 21:1104-17. 2001
    ..Antiproteolysis, particularly in the context of angiogenesis, has become a key target in therapeutic strategies aimed at inhibiting tumor growth and other diseases associated with neovascularization...
  86. ncbi Cellular receptor for urokinase plasminogen activator. Carboxyl-terminal processing and membrane anchoring by glycosyl-phosphatidylinositol
    M Ploug
    Finsen Laboratory, Rigshospitalet, Copenhagen, Denmark
    J Biol Chem 266:1926-33. 1991
    ..A similar proteolytic processing has been reported for other proteins that are linked to the plasma membrane by a glycosyl-phosphatidylinositol membrane anchor...
  87. ncbi Epidermal viral immunity induced by CD8alpha+ dendritic cells but not by Langerhans cells
    Rhys S Allan
    Department of Microbiology and Immunology, The University of Melbourne, Melbourne, Victoria 3010, Australia
    Science 301:1925-8. 2003
    ..Thus, the traditional view of Langerhans cells in epidermal immunity needs to be revisited to accommodate a requirement for other dendritic cells in this response...
  88. pmc Sialic acid receptor detection in the human respiratory tract: evidence for widespread distribution of potential binding sites for human and avian influenza viruses
    John M Nicholls
    Pathology Department, The University of Hong Kong, Pok Fu Lam, Hong Kong, Hong Kong SAR
    Respir Res 8:73. 2007
    ....
  89. ncbi Leptin and the regulation of body weight in mammals
    J M Friedman
    Laboratory of Molecular Genetics, Howard Hughes Medical Institute, Rockefeller University, New York, New York 10021, USA
    Nature 395:763-70. 1998
    ..Leptin also signals nutritional status to several other physiological systems and modulates their function. Here we review the role of leptin in the control of body weight and its relevance to the pathogenesis of obesity...
  90. ncbi Specialization and complementarity in microbial molecule recognition by human myeloid and plasmacytoid dendritic cells
    D Jarrossay
    Institute for Research in Biomedicine, Bellinzona, Switzerland
    Eur J Immunol 31:3388-93. 2001
    ..These results reveal a remarkable specialization and complementarity in microbial molecule recognition as well as a flexibility in effector function among myeloid and plasmacytoid DC...
  91. ncbi TRAM is specifically involved in the Toll-like receptor 4-mediated MyD88-independent signaling pathway
    Masahiro Yamamoto
    Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, 3 1 Yamada oka, Suita Osaka 565 0871, Japan
    Nat Immunol 4:1144-50. 2003
    ..TLR4- but not TLR3-mediated MyD88-independent interferon-beta production and activation of signaling cascades were abolished in TRAM-deficient cells. Thus, TRAM provides specificity for the MyD88-independent component of TLR4 signaling...
  92. ncbi Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression
    G M Lord
    Imperial College School of Medicine, Department of Immunology, The Hammersmith Hospital, London, UK
    Nature 394:897-901. 1998
    ..Our findings suggest a new role for leptin in linking nutritional status to cognate cellular immune function, and provide a molecular mechanism to account for the immune dysfunction observed in starvation...
  93. ncbi A receptor for the malarial parasite Plasmodium vivax: the erythrocyte chemokine receptor
    R Horuk
    Genentech, Inc, South San Francisco, CA 94080
    Science 261:1182-4. 1993
    ..Third, both MGSA and IL-8 blocked the binding of the parasite ligand and the invasion of human erythrocytes by P. knowlesi, suggesting the possibility of receptor blockade for anti-malarial therapy...
  94. ncbi Hedgehog signaling promotes prostate xenograft tumor growth
    Lian Fan
    Oncology Group, Cambridge, Massachusetts 02163, USA
    Endocrinology 145:3961-70. 2004
    ..Shh overexpression dramatically accelerates tumor growth. These data suggest that hedgehog signaling from prostate cancer cells to the stroma can elicit the expression of paracrine signals, which promote tumor growth...
  95. ncbi Endoglin expression is regulated by transcriptional cooperation between the hypoxia and transforming growth factor-beta pathways
    Tilman Sanchez-Elsner
    Centro de Investigaciones Biologicas, Consejo Superior de Investigaciones Cientificas, Ramiro de Maeztu 9, 28040 Madrid, Spain
    J Biol Chem 277:43799-808. 2002
    ..We propose that basal endoglin transcription (highly dependent on Sp1) may switch from a constitutive to an inducible state through Sp1 interaction with HIF-1 and Smad transcription factors, induced by hypoxia and TGF-beta, respectively...
  96. pmc Identification of a novel contactin-associated transmembrane receptor with multiple domains implicated in protein-protein interactions
    E Peles
    SUGEN, Inc, Redwood City, CA 94063, USA
    EMBO J 16:978-88. 1997
    ..The binding of RPTPbeta to the contactin-Caspr complex could provide a mechanism for cell-cell communication between glial cells and neurons during development...
  97. ncbi Hydrophobicity: an ancient damage-associated molecular pattern that initiates innate immune responses
    Seung Yong Seong
    Ghost Lab, Laboratory of Cellular and Molecular Immunology, National Insstitute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Nat Rev Immunol 4:469-78. 2004
  98. pmc Endoglin promotes endothelial cell proliferation and TGF-beta/ALK1 signal transduction
    Franck Lebrin
    Division of Cellular Biochemistry, The Netherlands Cancer Institute, Plesmanlaan, Amsterdam, The Netherlands
    EMBO J 23:4018-28. 2004
    ..Our results indicate a pivotal role for endoglin in the balance of ALK1 and ALK5 signalling to regulate endothelial cell proliferation...
  99. ncbi Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway
    Hiroaki Hemmi
    Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, 3 1 Yamada oka, Suita, Osaka 565 0871, Japan
    Nat Immunol 3:196-200. 2002
    ..Imidazoquinoline-induced signaling events were also abolished in both MyD88- and TLR7-deficient mice...
  100. ncbi The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog
    D M Stone
    Department of Neuroscience, Genentech, Inc, South San Francisco, California 94080, USA
    Nature 384:129-34. 1996
    ..These findings, combined with available genetic evidence from Drosophila, support the hypothesis that Ptc is a receptor for Shh, and that vSmo could be a signalling component that is linked to Ptc...
  101. ncbi Toll-like receptor signalling
    Shizuo Akira
    Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, and ERATO, Japan Science and Technology Agency, 3 1 Yamada oka, Suita, Osaka 565 0871, Japan
    Nat Rev Immunol 4:499-511. 2004

Research Grants71

  1. FASEB SRC on Lysophospholipd Mediators in Health and Disease
    Julie D Saba; Fiscal Year: 2011
    ..They signal through a family of ubiquitously expressed cell surface receptors, formerly called the Endothelial Differentiation Gene (EDG) receptors...
  2. Ethanol Regulation of Serum Glucocorticoid Kinase I
    BLAIR N COSTIN; Fiscal Year: 2012
    ..Functionally, Sgk1 is an important focal point of intracellular signaling cross-talk through which the cell surface receptors, nuclear receptors, and cellular stress pathways converge to control many cellular processes including ..
  3. Tissue-specific delivery of probes by control of membrane trafficking of endoprot
    Blake Peterson; Fiscal Year: 2010
    ..In this way, N-alkyl-3[unreadable]-cholesterylamines can function as small artificial cell surface receptors;when linked to motifs that bind drugs or molecular probes, they can shuttle these compounds into cells and ..
  4. Viral and Host Determinants of New World Alphaviral Entry
    ASIM AMINSHARIF AHMED; Fiscal Year: 2013
    ..map common receptor usage through a series of binding and infection competitions, and identify specific cell surface receptors by immunoprecipitation with soluble alphaviral E2 receptor binding domains...
  5. FASEB SUMMER CONFERENCE ON PHOSPHOLIPASES
    Alex Brown; Fiscal Year: 2010
    ..C generates inositol phosphate and diglyceride second messengers in response to agonist activation of cell surface receptors. Phospholipase D generates phosphatidic acid from phosphatidylcholine, to regulate organization of the ..
  6. Dual-Receptor Targeted Nanoparticles for Photodynamic Therapy of Brain Cancer
    Ann Marie Broome; Fiscal Year: 2013
    ..to Pc 4 and tethered peptide ligands for targeting epidermal growth factor (EGF) and transferrin (Tf) cell surface receptors, which are overexpressed in brain cancer cells...
  7. Modulation of Natriuretic Peptides via Caveolin in Hypertrophy and Heart Failure.
    David M Roth; Fiscal Year: 2013
    ..Molecular signaling involved in cardiac hypertrophy is complex and involves a number of cell surface receptors, signal transduction pathways and nuclear factors...
  8. Stat3 Downstream Genes as Lung Adenocarcinoma Biomarkers
    Cong Yan; Fiscal Year: 2013
    ..This work will identify protein biomarkers for lung cancer diagnosis and prognosis in humans and in animals. ..
  9. Inflammatory hyperalgesia due to TRPV1, the pepper spray receptor in the cornea
    Sharona E Gordon; Fiscal Year: 2013
    ....
  10. Serotonin transporter-mediated regulation of neuroendocrine exocytosis
    KEVIN P CURRIE; Fiscal Year: 2013
    ..Although 5HT is typically thought to act through cell surface receptors, recently it has been proposed to act as an intracellular signaling molecule in smooth muscle, platelets, ..
  11. Signal Transduction Mechanism of Osteoclast Differentiation
    Nandini Ghosh-Choudhury; Fiscal Year: 2013
    ..Interaction of BMP with its cell surface receptors activates Smad signaling pathway...
  12. REGULATION OF CXC CHEMOKINE EXPRESSION BY H. PYLORI
    Yoshio Yamaoka; Fiscal Year: 2013
    ..We will focus on the cell surface receptors epidermal growth factor receptor (EGFR) and G protein coupled receptor (GPCR)...
  13. Adhesion of Leptospira interrogans to Human Cell Surface Receptors
    Jenifer L Coburn; Fiscal Year: 2010
    ..abstract_text> ..
  14. THE ROLE OF A-BETA SPECIES IN VASCULAR SMOOTH MUSCLE CELL AND CEREBRAL ARTERIOLE
    Gregory J Zipfel; Fiscal Year: 2013
    ..and genetic inhibition of NADPH oxidase;d) pharmacologic and genetic inhibition of the A2-binding cell surface receptors, LRP1 and HSPGs;and e) quantitation of CAA, A[unreadable]40, A[unreadable]42, APP, and ApoE...
  15. Counter-Regulation of TLR-Driven Mucosal Inflammation
    Erik P Lillehoj; Fiscal Year: 2010
    ..Respiratory mucosal epithelial cells express a variety of cell surface receptors that signal the presence of potentially harmful inhaled substances...
  16. SIGNALING THROUGH RHO GTP/GDP EXCHANGE FACTORS
    Philip B Wedegaertner; Fiscal Year: 2013
    ..The research in this application will provide new knowledge about the functions of RhoGEFs and thus better define how the RhoGEFs can be therapeutically inhibited in disease without affecting their critical normal functions. ..
  17. Sphingolipids in Acute Kidney Injury
    MARK DOUGLAS OKUSA; Fiscal Year: 2013
    ..S1P has diverse cellular signaling responses on immune and nonimmune cells through cell surface receptors. This proposal focuses on the extracellular effects of S1P analogs through S1P1R and S1P3Rs on immune ..
  18. Association of a common variant of the PPAP2B gene with cardiovascular disease.
    Andrew J Morris; Fiscal Year: 2013
    ..The bioactive lysophospholipids, sphingosphine-1-phosphate (S1P) and lysophosphatidic acid (LPA), act on cell surface receptors expressed by many vascular cells...
  19. CRP, eNOS and Endothelial Dysfunction
    Philip W Shaul; Fiscal Year: 2010
    ..The proposed research program will determine how CRP and its cell surface receptors cause hypertension and insulin resistance.
  20. Distinct roles of CARP target genes in wound healing
    Karinna Almodóvar; Fiscal Year: 2013
    ..The matrix metalloproteinase (MMP) family regulates ECM remodeling. In concert, the integrin family of cell surface receptors mediates adhesive interactions between cells and the ECM...
  21. COLLAGEN GENE STRUCTURE AND EXPRESSION
    Bjorn Reino Olsen; Fiscal Year: 2013
    ..Genetic strategies will test hypotheses of how interactions between cell surface receptors and endostatin affect angiogenesis...
  22. Inhibited Intramembranous Bone Healing in Diabetes
    Philip C Trackman; Fiscal Year: 2013
    ..AGEs and TNF-a each contribute to complications of diabetes, and each interacts with osteoblast cell surface receptors resulting in increased levels of reactive oxygen species (ROS)...
  23. Plasminogen activator inhibitor-1 in tumor progression and metastasis
    Yves A DeClerck; Fiscal Year: 2013
    ..In Aim 1, we will investigate the mechanism by which the interaction between PAI-1 and one of its cell surface receptors, the low density lipoprotein receptor-like protein 1 (LRP1) signals and protects tumor cells from ..
  24. Exploiting toxins to probe sensory signaling
    David Julius; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVANCE Cell surface receptors and ion channels play essential roles in cellular communication throughout the body, including many ..
  25. Physiology and regulation of T2R bitter taste receptors in enteroendocrine cells
    Timothy F Osborne; Fiscal Year: 2013
    ..bitter constituents in food through individual small "bitter" molecule agonists stimulation of individual cell surface receptors. These taste 2 receptors (T2Rs) are encoded by a family of single-exon g- protein coupled receptor (GPCR) ..
  26. Vagal afferent cell bodies as sensors of blood-borne factors
    STEPHEN JOHN LEWIS; Fiscal Year: 2010
    ..This unique response mechanism may be vital in helping the body to defend the cardiovascular system against disease states that threaten human health such as high blood pressure, inflammation and diabetes. ..
  27. Neutrophil Migration in Three Dimensions
    Jonathan S Reichner; Fiscal Year: 2013
    ..Like all cells, neutrophils express a set of specific cell surface receptors that elicita functional response to biological elements within a microenvironment...
  28. The Role of Intracellular Metabotropic Glutamate Receptor 5 at the Synapse
    CAROLYN ANN PURGERT; Fiscal Year: 2012
    ..intracellular G-protein coupled receptors, and clinically, in targeting drugs to intracellular receptors, cell surface receptors, or both...
  29. Mechanisms Regulating Clathrin-Mediated Endocytosis
    Sandra L Schmid; Fiscal Year: 2013
    ..of endocytosis is critical to augmenting current therapeutic strategies that target the balance of cell surface receptors as a means of altering signal transduction in disease-related cell pathologies...
  30. Underlying Mechanisms of ApoE in HCV Infection and Assembly
    GUANGXIANG GEORGE LUO; Fiscal Year: 2013
    ..and challenges the current dogma that viral envelope proteins mediate virus attachment by binding to cell surface receptors. New knowledge originating from these studies will result in a paradigm change regarding the roles of ..
  31. ApoE receptor pathways and abeta metabolism
    Guojun Bu; Fiscal Year: 2013
    ..A[unreadable] clearance and aggregation are regulated by A[unreadable] chaperones and cell surface receptors. Apolipoprotein E (apoE) is a major A[unreadable] chaperone and cholesterol carrier in the brain...
  32. Cytoskeletal Regulation During Growth Cone Migration and Axon Guidance
    Frank B Gertler; Fiscal Year: 2012
    ..We seek a comprehensive understanding of how nerve fibers form and are guided to their targets initially during fetal development expecting that this will help us learn to repair damage to the brain. ..
  33. The Renal Pathogenicity of Anti-DNA Antibodies
    Chaim Putterman; Fiscal Year: 2013
    ..antibodies in kidney cells is an important contributor to the pathogenesis of LN, mediated by binding to cell surface receptors and engagement of an additional receptor from the Toll-like receptor (TLR) family, and that serum and/or ..
  34. Hepatic drug metabolism in inflammation
    Romi Ghose; Fiscal Year: 2009
    ..Specific Aim 1: Determine whether the cell surface receptors, TLR2 and TLR4 and the critical adaptor proteins (TIRAP, TRIP), are involved in regulation of DMEs and NRs ..
  35. Manipulating Macrophage Phenotype in Laryngeal Nerve Repair
    Jonathan Cheetham; Fiscal Year: 2013
    ..In specific aim 1, we will use transgenic knock-out mice to demonstrate the effects of deletion of cell surface receptors that control macrophage phenotype on nerve repair immediately and up to 4 months after injury...
  36. Signal transduction mechanisms to myosin phosphatase
    James T Stull; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Activation of many cell surface receptors initiates diverse cellular movements such as cell migration, cell- matrix adhesion and contraction...
  37. Novel Roles of Intracrine Angiotensin II in Proximal Tubule Cells
    Jia Zhuo; Fiscal Year: 2009
    ..Ang II exerts powerful effects on proximal tubular sodium and fluid transport by activating cell surface receptors on apical and basolateral membranes of proximal tubule cells...
  38. FIBRONECTIN REGULATION OF CARCINOMA APOPTOSIS
    Yvonne Kapila; Fiscal Year: 2009
    ..These studies will help explain some of the cell-matrix interactions and signaling mechanisms that regulate tumor cell biology, and may provide insights into the pathogenesis of oral SCC. ..
  39. Quantitative Optical Imaging of Molecular Processes in Preclinical Cancer Models
    WALTER JOHN AKERS; Fiscal Year: 2013
    ..Detection of therapeutic response early initiation can speed the clinical decision- making process and improve overall response. Non-invasive imaging techniques are needed for this purpose. ..
  40. Combination immunotherapy for neuroblastoma: model of innate tumor immunity
    Shakeel Modak; Fiscal Year: 2013
    ..The capacity of an NK cell for cytotoxic response, however, is dictated by its cell surface receptors, specifically the inhibitory and activating killer-Ig like receptors (KIR) that are specific for sel-MHC ..
  41. DNA Nuclear Import Sequences for Cell-Specific Gene and Drug Delivery
    David A Dean; Fiscal Year: 2013
    ..cell types and tissues: physical delivery to a desired target organ, use of ligands or antibodies for cell surface receptors, and cell-specific promoters to drive transcription in desired cell types...
  42. Anti-melanoma Activity of Combined Lymphopenia and Immunotherapy
    Shari Pilon-Thomas; Fiscal Year: 2012
    ..These finding could have significant translation to human clinical immunotherapeutic trials. ..
  43. Cell-Binding Adhesins of Leptospira interrogans
    Jenifer L Coburn; Fiscal Year: 2013
    ..approaches to identify Leptospira interrogans molecules involved specifically in attachment to human cell surface receptors and altering the biology of host cells...
  44. G Protein Coupled Receptor Modulation of Synaptic Transmission
    EDAENI YISHAK HAMID; Fiscal Year: 2010
    ..GPCRs are the largest family of cell surface receptors. Therefore, understanding how these receptors exhibit their myriad effects is vital...
  45. Biologic Activities of the pertusis toxin B-pentamer
    ALISON A contact WEISS; Fiscal Year: 2010
    ..We will identify the essential PTX-B binding regions as a prelude to the identification of potential cell surface receptors. Specific Aim 2...
  46. Sphingolipid Signaling in Endothelial Responses to Injury
    TERESA SANCHEZ GARCIA-VAO; Fiscal Year: 2013
    ..a lipid, very abundant in plasma, which regulates many cellular functions through the interaction with its cell surface receptors S1P1-5R...
  47. TRADD as a Regulator of Cytokine Signaling in Glia
    ETTY BENVENISTE; Fiscal Year: 2009
    ..Macrophages/microglia also respond to cytokines upon engagement of cell surface receptors and activation of complex intracellular signaling pathways...
  48. DNA-binding polyamides as Hedgehog inhibitors in human carcinoma
    Amanda E Hargrove; Fiscal Year: 2012
    ..In normal HH signaling, exogenous HH ligands bind to cell surface receptors, resulting in a signaling cascade that culminates in the activation of the Gli2 transcription factor...
  49. RECEPTOR-MEDIATED TRANSPORT OF LYSOSOMAL ENZYMES
    William S Sly; Fiscal Year: 2013
    ..not accessible to native enzyme can be targeted successfully using chimeric enzymes that target other cell surface receptors. We have four Specific Aims: 1) Determine the mechanism and significance of pharmacological upregulation ..
  50. Smooth Muscle Cell Protein Serotonylation and Pulmonary Hypertension
    BARRY FANBURG; Fiscal Year: 2013
    ..through the tissue enzyme transglutaminase (TGase), is influenced by the PDGF receptor and possibly other cell surface receptors that have been associated with PH...
  51. Novel Roles of Intracrine Angiotensin II in Proximal Tubule Cells
    Jia L Zhuo; Fiscal Year: 2013
    ..Ang II exerts powerful effects on PT sodium and fluid transport by activating cell surface receptors on apical and basolateral membranes of PT cells...
  52. Inflammatory Breast Cancer: Factors Contributing to Dissemination
    Bonnie F Sloane; Fiscal Year: 2012
    ..expression/secretion/activity of cysteine cathepsins; 4) Immunostain paraffin blocks of IBC specimens for cell surface receptors of selected cytokines, chemokines and growth factors;and, 5) Establish 3D cocultures of IBC cells and ..
  53. Regulation of EGFR Signaling by the Endocytic Pathway
    Brian P Ceresa; Fiscal Year: 2013
    ..provided by applicant): The long-term goal of our laboratory is to understand how signal transduction by cell surface receptors is regulated...
  54. Developing Immature Nucleus Pulposus Cells for Regenerative Therapy
    Jun Chen; Fiscal Year: 2013
    ..are a metabolically and phenotypically distinct NP cell population, with unique expression patterns for cell surface receptors, matrix and secreted proteins that are altered upon aging...
  55. CARMA3-mediated NF-kappaB activation in GPCR signaling pathways
    Xin Lin; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): G protein-coupled receptors (GPCRs) constitute a large family of cell surface receptors, and play an important role in regulating cell survival and proliferation...
  56. Role of PDZK1 in lipid metabolism and atherosclerosis
    Olivier N Kocher; Fiscal Year: 2013
    ..likely to be a growing family of cytoplasmic adaptor proteins that control the tissue specific activity of cell surface receptors. More recently, we have determined, using a transgenic mouse model in which truncated forms of PDZK1 were ..
  57. Understanding the role of myosin in endocytosis
    ERIC BRECHER LEWELLYN; Fiscal Year: 2013
    ..is a conserved pathway in eukaryotic cells for internalizing external macromolecules, membrane lipids, and cell surface receptors. Perturbation of this process is associated with multiple types of cancer and endocytic internalization is ..
  58. Characterization of a GPCR-blocking antibody for the treatment of breast cancer.
    GARRET GUENTHER; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): G protein-coupled receptors (GPCRs) represent a diverse family of cell surface receptors that mediate important biological responses in nearly all cells...
  59. Intracellular Target of Sphingosine-1-Phosphate
    GRAHAM M STRUB; Fiscal Year: 2010
    ..nerve growth factor (NGF) and neurotrophin-3 (NT- 3), and many of its functions are mediated by its cell surface receptors (S1P1-5)...
  60. Molecular regulation of breast cancer growth
    Marsha A Moses; Fiscal Year: 2010
    ....
  61. Barrier Dysfunction in Severe Surgical Diseases
    Douglas J Turner; Fiscal Year: 2012
    ..S1P's effects are mediated through specific cell surface receptors (S1PR) which govern intracellular cytoskeletal organization and in particular regulate the organization ..
  62. Synthetic Cell Surface Receptors for Anticancer Drug Delivery
    Blake Peterson; Fiscal Year: 2012
    ..In this way, N-alkyl-3?-cholesterylamines can function as small artificial cell surface receptors;when linked to drug-binding motifs, they can shuttle drugs into cells and tissues via endocytosis...
  63. S100A8/A9 and carboxylated N-glycans in inflammation-mediated colon cancer
    GEETHA K SRIKRISHNA; Fiscal Year: 2010
    ..This project will study how sugars expressed in cell surface receptors and ligands that bind to them mediate intracellular activation, gene expression and inflammation-induced ..
  64. EFFECT OF APOLIPOPROTEIN STRUCTURAL ADAPTABILITY
    ROBERT O apos MARA RYAN; Fiscal Year: 2010
    ..The long-term goal of our research is to understand how molecular interactions between lipoproteins and cell surface receptors affect lipid metabolism and disease susceptibility...
  65. Adhesion of Leptospira interrogans to Human Cell Surface Receptors
    Jenifer Coburn; Fiscal Year: 2009
    ..is to identify leptospiral and mammalian molecules required for these bacteria to cause infection and disease, and for the purposes of this proposal we will focus on identifying the mammalian cell surface receptors for L. interrogans.
  66. Mechanisms of Microglial Activation and Phagocytosis in*
    Gary Landreth; Fiscal Year: 2005
    ..We believe that the solution to this problem requires a detailed understanding of the nature of the cell surface receptors engaged by the AB fibril, and their linkage to the phagocytic machinery...
  67. REGULATORY DOMAINS OF G PROTEIN COUPLED RECEPTORS
    Ellen Weiss; Fiscal Year: 2002
    G protein-coupled receptors are a family of cell surface receptors that regulate G protein signaling pathways in response to a variety of environmental stimuli...
  68. Nanoscale patterning that promotes cell adhesion
    HEATHER MAYNARD; Fiscal Year: 2006
    ..DO NOT EXCEED THE SPACE PROVIDED. Project Summary. Cell adhesion is governed by interactions of cell surface receptors with proteins found in the extracellular matrix (ECM)...
  69. Positive and Negative Regulatory Pathways In Human Lymphoma
    Richard Ford; Fiscal Year: 2007
    ..b>cell surface receptors. Normal B cells, involved in inflammatory, or other immune functions, transduce signals to activate and ..
  70. BASIC AND CLINICAL STUDIES OF COAGULATION PROTEINS
    Charles Francis; Fiscal Year: 2003
    ..Specific studies will define the structural domains of fibrinogen and cell surface receptors required for assembly of fibrinogen into matrix, examine cell response, examine structural domains of ..
  71. Screening for Inhibitors of the Integrated Stress Response
    David Ron; Fiscal Year: 2007
    ..provided by applicant): A large number of biologically important proteins, such as hormones, enzymes and cell surface receptors undergo early steps of their biogenesis in the endoplasmic reticulum (ER)...