p selectin

Summary

Summary: Cell adhesion molecule and CD antigen that mediates the adhesion of neutrophils and monocytes to activated platelets and endothelial cells.

Top Publications

  1. ncbi Expression cloning of a functional glycoprotein ligand for P-selectin
    D Sako
    Genetics Institute, Small Molecule Drug Discovery Group, Cambridge, Massachusetts 02140
    Cell 75:1179-86. 1993
  2. ncbi Insights into the molecular basis of leukocyte tethering and rolling revealed by structures of P- and E-selectin bound to SLe(X) and PSGL-1
    W S Somers
    Genetics Institute, Wyeth Research, Cambridge, Massachusetts 02140, USA
    Cell 103:467-79. 2000
  3. pmc Infectious susceptibility and severe deficiency of leukocyte rolling and recruitment in E-selectin and P-selectin double mutant mice
    D C Bullard
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    J Exp Med 183:2329-36. 1996
  4. ncbi Rapid upregulation of endothelial P-selectin expression via reactive oxygen species generation
    Manabu Takano
    Department of Surgery, The Johns Hopkins University School of Medicine, 600 N Wolfe Street, Baltimore, MD 21287, USA
    Am J Physiol Heart Circ Physiol 283:H2054-61. 2002
  5. pmc GMP-140, a platelet alpha-granule membrane protein, is also synthesized by vascular endothelial cells and is localized in Weibel-Palade bodies
    R P McEver
    St Francis Medical Research Institute, University of Oklahoma Health Science Center, Oklahoma City 73104
    J Clin Invest 84:92-9. 1989
  6. pmc Targeted gene disruption demonstrates that P-selectin glycoprotein ligand 1 (PSGL-1) is required for P-selectin-mediated but not E-selectin-mediated neutrophil rolling and migration
    J Yang
    Center for Hemostasis, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Exp Med 190:1769-82. 1999
  7. ncbi Specialized contributions by alpha(1,3)-fucosyltransferase-IV and FucT-VII during leukocyte rolling in dermal microvessels
    W Weninger
    The Center for Blood Research and Department of Pathology, Children s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Immunity 12:665-76. 2000
  8. ncbi Platelets: physiology and biochemistry
    Kerstin Jurk
    Department of Anaesthesiology and Intensive Care, Experimental and Clinical Haemostasis, University Hospital Munster, Munster, Germany
    Semin Thromb Hemost 31:381-92. 2005
  9. pmc Podocalyxin-like protein is an E-/L-selectin ligand on colon carcinoma cells: comparative biochemical properties of selectin ligands in host and tumor cells
    Susan N Thomas
    Dept of Chemical and Biomolecular Engineering, The Johns Hopkins Univ, 3400 N Charles St, Baltimore, MD 21218, USA
    Am J Physiol Cell Physiol 296:C505-13. 2009
  10. ncbi Thrombogenesis in sickle cell disease
    A Tomer
    Department of Hematology and Oncology, Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA 30303, USA
    J Lab Clin Med 137:398-407. 2001

Detail Information

Publications290 found, 100 shown here

  1. ncbi Expression cloning of a functional glycoprotein ligand for P-selectin
    D Sako
    Genetics Institute, Small Molecule Drug Discovery Group, Cambridge, Massachusetts 02140
    Cell 75:1179-86. 1993
    ..A soluble ligand construct, when coexpressed with fucosyltransferase in COS cells, also mediates P-selectin binding and is immunocrossreactive with the major HL-60 glycoprotein that specifically binds P-selectin...
  2. ncbi Insights into the molecular basis of leukocyte tethering and rolling revealed by structures of P- and E-selectin bound to SLe(X) and PSGL-1
    W S Somers
    Genetics Institute, Wyeth Research, Cambridge, Massachusetts 02140, USA
    Cell 103:467-79. 2000
    ..These structures reveal differences in how E- and P-selectin bind SLe(X) and the molecular basis of the high-affinity interaction between P-selectin and PSGL-1...
  3. pmc Infectious susceptibility and severe deficiency of leukocyte rolling and recruitment in E-selectin and P-selectin double mutant mice
    D C Bullard
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    J Exp Med 183:2329-36. 1996
    ..These mice provide strong evidence for the functional importance of selectins in vivo...
  4. ncbi Rapid upregulation of endothelial P-selectin expression via reactive oxygen species generation
    Manabu Takano
    Department of Surgery, The Johns Hopkins University School of Medicine, 600 N Wolfe Street, Baltimore, MD 21287, USA
    Am J Physiol Heart Circ Physiol 283:H2054-61. 2002
    ....
  5. pmc GMP-140, a platelet alpha-granule membrane protein, is also synthesized by vascular endothelial cells and is localized in Weibel-Palade bodies
    R P McEver
    St Francis Medical Research Institute, University of Oklahoma Health Science Center, Oklahoma City 73104
    J Clin Invest 84:92-9. 1989
    ..The restricted expression of GMP-140 in secretory granules of platelets and endothelium suggests that it has a specific function in the vascular system rather than a general role related to inducible secretion...
  6. pmc Targeted gene disruption demonstrates that P-selectin glycoprotein ligand 1 (PSGL-1) is required for P-selectin-mediated but not E-selectin-mediated neutrophil rolling and migration
    J Yang
    Center for Hemostasis, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Exp Med 190:1769-82. 1999
    ..These kinetics are consistent with a model in which PSGL-1 is the predominant neutrophil P-selectin ligand but is not a required counterreceptor for E-selectin under in vivo physiological conditions...
  7. ncbi Specialized contributions by alpha(1,3)-fucosyltransferase-IV and FucT-VII during leukocyte rolling in dermal microvessels
    W Weninger
    The Center for Blood Research and Department of Pathology, Children s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Immunity 12:665-76. 2000
    ..These results demonstrate a role for FucT-IV in selectin-dependent adhesion and suggest that the endothelial selectins and FucTs have distinct but overlapping functions in the immunosurveillance of the skin...
  8. ncbi Platelets: physiology and biochemistry
    Kerstin Jurk
    Department of Anaesthesiology and Intensive Care, Experimental and Clinical Haemostasis, University Hospital Munster, Munster, Germany
    Semin Thromb Hemost 31:381-92. 2005
    ..Finally, special emphasis is placed on important stimulatory and inhibitory signaling pathways that modulate platelet function...
  9. pmc Podocalyxin-like protein is an E-/L-selectin ligand on colon carcinoma cells: comparative biochemical properties of selectin ligands in host and tumor cells
    Susan N Thomas
    Dept of Chemical and Biomolecular Engineering, The Johns Hopkins Univ, 3400 N Charles St, Baltimore, MD 21218, USA
    Am J Physiol Cell Physiol 296:C505-13. 2009
    ..The novel finding that PCLP is an E-/L-selectin ligand on carcinoma cells offers a unifying perspective on the apparent enhanced metastatic potential associated with tumor cell PCLP overexpression and the role of selectins in metastasis...
  10. ncbi Thrombogenesis in sickle cell disease
    A Tomer
    Department of Hematology and Oncology, Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA 30303, USA
    J Lab Clin Med 137:398-407. 2001
    ..These changes are predictive of frequency of pain and interval to next pain episode, thereby implicating thrombogenic activity in the development of SCD pain episodes...
  11. ncbi The P-selectin gene is highly polymorphic: reduced frequency of the Pro715 allele carriers in patients with myocardial infarction
    S M Herrmann
    INSERM SC7, 17 Rue du Fer a Moulin, 75005 Paris, France
    Hum Mol Genet 7:1277-84. 1998
    ..Whether this variant affects the properties of the P-selectin protein in a way which is compatible with this hypothesis needs to be checked experimentally...
  12. ncbi Vascular endothelial growth factor and soluble P-selectin in acute and chronic congestive heart failure
    Bernard S P Chin
    Haemostasis Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham, United Kingdom
    Am J Cardiol 90:1258-60. 2002
  13. ncbi DNA polymorphisms in adhesion molecule genes--a new risk factor for early atherosclerosis
    K Wenzel
    Department of Internal Medicine I, Charite, Humboldt University, Berlin, Germany
    Hum Genet 97:15-20. 1996
    ..Results suggest that these polymorphisms are associated with a higher risk for early severe atherosclerosis...
  14. ncbi Investigating the feasibility of stem cell enrichment mediated by immobilized selectins
    Nichola Charles
    Department of Biomedical Engineering, University of Rochester, Rochester, New York, USA
    Biotechnol Prog 23:1463-72. 2007
    ..Optimal cell enrichment in immobilized selectin surfaces can be achieved within 10 min, much faster than most current commercially available systems...
  15. ncbi Serum-soluble selectin levels in patients with rheumatoid arthritis and systemic sclerosis
    A Ates
    Department of Clinical Immunology and Rheumatology, Ankara University Medical School, Ankara, Turkey
    Scand J Immunol 59:315-20. 2004
    ..Serum levels of selectins may provide a useful additional marker for disease activity in RA patients and for disease severity in SSc patients...
  16. pmc Embryonic trafficking of gammadelta T cells to skin is dependent on E/P selectin ligands and CCR4
    Xiaodong Jiang
    Department of Dermatology, Harvard Skin Disease Research Center, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 107:7443-8. 2010
    ..We demonstrate that DETC in adult skin, as well as the DETC precursors in fetal thymus, express E and P selectin ligands (E- and P-lig)...
  17. ncbi Increased plasma P-selectin and decreased thrombomodulin in pulmonary arterial hypertension were improved by continuous prostacyclin therapy
    F Sakamaki
    Division of Cardiology and Pulmonary Circulation, Department of Medicine, National Cardiovascular Center, Osaka, Japan
    Circulation 102:2720-5. 2000
    ....
  18. ncbi The influence of acute smoking on leucocytes, platelets and the endothelium
    A D Blann
    University Department of Medicine, City Hospital, Birmingham, UK
    Atherosclerosis 141:133-9. 1998
    ..We conclude that the acute smoking of two cigarettes in succession will activate leucocytes and cause endothelial cell damage, but will not immediately influence platelet activity...
  19. pmc Endothelium-derived Toll-like receptor-4 is the key molecule in LPS-induced neutrophil sequestration into lungs
    Graciela Andonegui
    Immunology Research Group, Department of Physiology and Biophysics, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada
    J Clin Invest 111:1011-20. 2003
    ..In conclusion, our data challenge the view that LPS directly activates neutrophils to trap in lungs and suggest a far more important role than previously appreciated for the endothelial cells...
  20. pmc Agent-based model of therapeutic adipose-derived stromal cell trafficking during ischemia predicts ability to roll on P-selectin
    Alexander M Bailey
    Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia, USA
    PLoS Comput Biol 5:e1000294. 2009
    ..Thus, our work led to a fundamentally new understanding of hASC biology, which may have important therapeutic implications...
  21. ncbi P-selectin mediates adhesion of leukocytes, platelets, and cancer cells in inflammation, thrombosis, and cancer growth and metastasis
    Ming Chen
    Laboratory of Molecular Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Graduate School of Chinese Academy of Sciences, Shanghai, 200031, China
    Arch Immunol Ther Exp (Warsz) 54:75-84. 2006
    ..Here we provide a comprehensive summary of the functional roles and the biological importance of P-selectin-mediated cell adhesive interactions in the pathogeneses of inflammation, thrombosis, and the growth and metastasis of cancers...
  22. ncbi Course of platelet activation markers after ischemic stroke
    Lars Marquardt
    Department of Neurology, University of Heidelberg, Germany
    Stroke 33:2570-4. 2002
    ..The aim of this study was to evaluate the time course of platelet activation after ischemic stroke and to investigate whether platelet activation and inflammation are correlated with each other...
  23. pmc Defect in regulated secretion of P-selectin affects leukocyte recruitment in von Willebrand factor-deficient mice
    C V Denis
    Center for Blood Research, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 98:4072-7. 2001
    ..This defect results in decreased P-selectin translocation to the cell surface and reduced leukocyte recruitment in early phases of inflammation...
  24. ncbi Expression of adhesion molecules by endovascular trophoblast and decidual endothelial cells: implications for vascular invasion during implantation
    T D Burrows
    Department of Pathology, University of Cambridge, UK
    Placenta 15:21-33. 1994
    ..Our data suggests that vascular invasion by trophoblast is regulated by the expression of appropriate adhesion molecules which permit interaction between endovascular trophoblast and decidual endothelial cells...
  25. ncbi Platelet-endothelial cell interactions during ischemia/reperfusion: the role of P-selectin
    S Massberg
    Ludwig Maximilians University, Institute for Surgical Research, Klinikum Grosshadern, Munich, Germany
    Blood 92:507-15. 1998
    ..Platelet recruitment and subsequent activation might play an important role in the pathogenesis of I/R injury...
  26. pmc Adhesive dynamics simulation of G-protein-mediated chemokine-activated neutrophil adhesion
    Kelly E Caputo
    Department of Chemical and Biomolecular Engineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Biophys J 96:2989-3004. 2009
    ....
  27. pmc P-Selectin glycoprotein ligand 1 (PSGL-1) is expressed on platelets and can mediate platelet-endothelial interactions in vivo
    P S Frenette
    The Center for Blood Research, Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
    J Exp Med 191:1413-22. 2000
    ..Our results indicate that functional PSGL-1 is expressed on platelets, and suggest an additional mechanism by which selectins and their ligands participate in inflammatory and/or hemostatic responses...
  28. ncbi Platelet activation markers and soluble adhesion molecules in patients with systemic lupus erythematosus
    M Nagahama
    The First Department of Internal Medicine, Kansai Medical University, Osaka, Japan
    Autoimmunity 33:85-94. 2001
    ..These findings suggest the possibility that activated platelets and cytokines participate in the pathogenesis of SLE in patients with elevated sTM levels...
  29. ncbi P-selectin glycoprotein ligand-1 supports rolling on E- and P-selectin in vivo
    K E Norman
    Cardiovascular Research Group and Section of Surgery, Division of Clinical Sciences NGH, University of Sheffield, United Kingdom
    Blood 96:3585-91. 2000
    ..The results suggest that P-selectin-PSGL-1 interaction alone is sufficient to mediate rolling in vivo and that E-selectin-PSGL-1 interaction supports slow rolling...
  30. ncbi CD4+ T cells migrate into inflamed skin only if they express ligands for E- and P-selectin
    W Tietz
    Department of Immunology, Medical Clinic, University Hospital Eppendorf, Hamburg, Germany
    J Immunol 161:963-70. 1998
    ..These data indicate that the expression of functional ligands for E- and for P-selectin is essential for homing of CD4+ T cells into the inflamed skin...
  31. ncbi Soluble P selectin levels in chronic liver disease: relationship to disease severity
    Eser Vardareli
    Osmangazi University, Medical Faculty, Department of Gastroenterology, Eskisehir, Turkey
    Hepatogastroenterology 54:466-9. 2007
    ....
  32. ncbi The roles of L-selectin, beta 7 integrins, and P-selectin in leukocyte rolling and adhesion in high endothelial venules of Peyer's patches
    E J Kunkel
    Department of Biomedical Engineering, University of Virginia School of Medicine, Charlottesville 22908, USA
    J Immunol 161:2449-56. 1998
    ..In situ, beta 7 integrins and L-selectin account for all lymphocyte homing to Peyer's patches, but P-selectin-dependent rolling, as induced by minimal trauma, may support trafficking of effector T lymphocytes to Peyer's patches...
  33. ncbi P-selectin expression on platelets determines size and stability of platelet aggregates
    M Merten
    Division of Cardiology, Department of Internal Medicine, University of Texas Houston Medical School 77030, USA
    Circulation 102:1931-6. 2000
    ..After platelet activation, P-selectin is translocated from intracellular granules to the external membrane, whereas fibrinogen aggregates platelets by bridging glycoprotein (GP) IIb/IIIa between adjacent platelets...
  34. ncbi A journey with platelet P-selectin: the molecular basis of granule secretion, signalling and cell adhesion
    B Furie
    Center for Hemostasis and Thrombosis Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Thromb Haemost 86:214-21. 2001
    ..P-selectin upregulates tissue factor in monocytes and leads to leukocyte accumulation in areas of vascular injury associated with thrombosis and inflammation...
  35. pmc Tyrosine sulfation enhances but is not required for PSGL-1 rolling adhesion on P-selectin
    S D Rodgers
    Department of Bioengineering, Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Biophys J 81:2001-9. 2001
    ..These findings are consistent with structural and functional characterizations of the interactions between these peptides and E- and P-selectin published recently...
  36. pmc Dynamic alterations of membrane tethers stabilize leukocyte rolling on P-selectin
    Vishwanath Ramachandran
    Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    Proc Natl Acad Sci U S A 101:13519-24. 2004
    ..Gradual remodeling of tether architecture may further reduce rolling velocities, facilitating integrin-dependent deceleration and arrest on inflamed vascular surfaces...
  37. ncbi Heat-stable antigen (CD24) as ligand for mouse P-selectin
    M Sammar
    Tumor Immunology Programme, German Cancer Research Center, Heidelberg
    Int Immunol 6:1027-36. 1994
    ..It is suggested that in its L2/HNK-1 modified form the HSA molecule on leukocytes could represent a ligand for P-selectin on endothelial cells or platelets...
  38. ncbi Platelet microparticles and soluble P selectin in peripheral artery disease: relationship to extent of disease and platelet activation markers
    Kiat T Tan
    Haemostasis, Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham B18 7QH, UK
    Ann Med 37:61-6. 2005
    ..Furthermore, we tested the hypothesis that PMP levels are correlated with other markers of platelet activation, such as soluble P-selectin, membrane bound P-selectin (CD62P) and 63...
  39. ncbi Soluble P selectin in systemic sclerosis: relationship with von Willebrand factor, autoantibodies and diffuse or localised/limited disease
    A D Blann
    Haemostasis, Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Dudley Road, Birmingham B18 7QH, UK
    Thromb Res 109:203-6. 2003
  40. ncbi In vitro effects of gelatin solutions on platelet function: a comparison with hydroxyethyl starch solutions
    U Thaler
    Department of General Anesthesiology and Intensive Care B, Vienna Medical University, 1090 Vienna, Austria
    Anaesthesia 60:554-9. 2005
    ..p-selectin expression remained unchanged in all samples. The present in vitro study indicates that chemical characteristics of colloidal solutions modulate their influence on platelet reactivity...
  41. ncbi P-selectin suppresses hepatic inflammation and fibrosis in mice by regulating interferon gamma and the IL-13 decoy receptor
    Thomas A Wynn
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 50, Room 6154, MSC 8003, Bethesda, MD 20892, USA
    Hepatology 39:676-87. 2004
    ..By suppressing IFN-gamma and up-regulating the decoy IL-13 receptor, P-selectin dramatically inhibits the pathologic tissue remodeling that results from chronic type 2 cytokine-mediated inflammation...
  42. ncbi Platelet-leukocyte-endothelial cell interactions after middle cerebral artery occlusion and reperfusion
    Mami Ishikawa
    Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, Shreveport, Louisiana 71130 3932, USA
    J Cereb Blood Flow Metab 24:907-15. 2004
    ..These findings implicate a major role for both platelet-associated and endothelial cell-associated P-selectin, as well as neutrophils in the inflammatory and prothrombogenic responses in the microcirculation after focal cerebral I/R...
  43. ncbi Attachment of the PSGL-1 cytoplasmic domain to the actin cytoskeleton is essential for leukocyte rolling on P-selectin
    Karen R Snapp
    Department of Microbiology Immunology, Northwestern University Medical School, Chicago, IL 60611, USA
    Blood 99:4494-502. 2002
    ..Thus, attachment of PSGL-1 to the leukocyte cortical cytoskeleton is essential for leukocyte rolling on P-selectin...
  44. pmc P-selectin glycoprotein ligand-1-deficient mice have impaired leukocyte tethering to E-selectin under flow
    Lijun Xia
    Warren Medical Research Institute and Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
    J Clin Invest 109:939-50. 2002
    ..The residual PSGL-1-/- leukocytes that tethered rolled with slow velocities equivalent to those of PSGL-1+/+ leukocytes. These results reveal a novel function for PSGL-1 in tethering leukocytes to E-selectin under flow...
  45. pmc Remodeling of the lectin-EGF-like domain interface in P- and L-selectin increases adhesiveness and shear resistance under hydrodynamic force
    Uyen T Phan
    CBR Institute for Biomedical Research, Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Immunol 7:883-9. 2006
    ..Our results demonstrate that force, by 'favoring' an extended selectin conformation, can strengthen selectin-ligand bonds...
  46. pmc Distinct molecular and cellular contributions to stabilizing selectin-mediated rolling under flow
    Tadayuki Yago
    Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, OK 74104, USA
    J Cell Biol 158:787-99. 2002
    ..Thus, stable, shear-resistant rolling requires cellular properties that optimize selectin-ligand interactions...
  47. ncbi A novel P-selectin glycoprotein ligand-1 monoclonal antibody recognizes an epitope within the tyrosine sulfate motif of human PSGL-1 and blocks recognition of both P- and L-selectin
    K R Snapp
    Department of Microbiology Immunology, Northwestern University Medical School, Chicago, IL 60611, USA
    Blood 91:154-64. 1998
    ..Variation in tyrosine sulfation during B-cell differentiation may affect the ability of B cells to interact with P- and L-selectin...
  48. ncbi Platelet morphology, soluble P selectin and platelet P-selectin in acute ischaemic stroke. The West Birmingham Stroke Project
    Sunil K Nadar
    Haemostasis Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham B18 7QH, UK
    Thromb Haemost 92:1342-8. 2004
    ..Further study of platelet activation and the role of P-selectin is warranted...
  49. ncbi Treatment with an oral small molecule inhibitor of P selectin (PSI-697) decreases vein wall injury in a rat stenosis model of venous thrombosis
    Daniel D Myers
    Jobst Vascular Research Laboratories, Section of Vascular Surgery, University of Michigan Medical Center, Ann Arbor, 48109 0654, USA
    J Vasc Surg 44:625-32. 2006
    ....
  50. ncbi Role of selectins in experimental Staphylococcus aureus-induced arthritis
    M Verdrengh
    Department of Rheumatology, University of Goteborg, Sweden
    Eur J Immunol 30:1606-13. 2000
    ..aureus-induced arthritis: on the one hand, blockade of these selectins leads to less severe arthritic lesions in the initial stage of the disease; on the other, delayed recruitment of phagocytes decreases the clearance of bacteria...
  51. ncbi P38 MAPK: critical molecule in thrombin-induced NF-kappa B-dependent leukocyte recruitment
    Jaswinder Kaur
    Immunology Research Group, Department of Physiology, University of Calgary, Calgary, Alberta, Canada T2N 4N1
    Am J Physiol Heart Circ Physiol 284:H1095-103. 2003
    ..These data suggest that thrombin induces p38 MAPK activation, which leads to NF-kappa B mobilization to the nucleus and causes the upregulation of E-selectin and subsequent leukocyte recruitment...
  52. ncbi Decreased venous thrombosis with an oral inhibitor of P selectin
    Daniel D Myers
    Section of Vascular Surgery, Jobst Vascular Research Laboratories, Ann Arbor, Mich, USA
    J Vasc Surg 42:329-36. 2005
    ..In this study, we hypothesized that oral inhibition of P selectin with a novel oral nonprotein inhibitor (PSI-697) would decrease thrombosis and circulating microparticle ..
  53. ncbi Recombinant soluble form of PSGL-1 accelerates thrombolysis and prevents reocclusion in a porcine model
    A Kumar
    Preclinical R and D, Genetics Institute, Inc, Andover, MA, USA
    Circulation 99:1363-9. 1999
    ....
  54. pmc P-selectin mediates neutrophil rolling on histamine-stimulated endothelial cells
    D A Jones
    Rice University, Houston, Texas 77251 1892
    Biophys J 65:1560-9. 1993
    ..We further characterize these interactions by determining the effects of the various MAbs and wall shear stresses on adhesion patterns, rolling velocities, and distributions of rolling velocities...
  55. ncbi Synergism between platelets and neutrophils in provoking cardiac dysfunction after ischemia and reperfusion: role of selectins
    A M Lefer
    Department of Physiology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA, USA
    Circulation 98:1322-8. 1998
    ..This study was designed to test the effects of PMNs and platelets separately and together in provoking cardiac dysfunction in isolated perfused rat hearts after ischemia and reperfusion...
  56. pmc Determinants in the cytoplasmic domain of P-selectin required for sorting to secretory granules
    P W Modderman
    Department of Immunohaematology, Central Laboratory of the Netherlands Red Cross Blood Transfusion Service, University of Amsterdam, Academic Medical Center, The Netherlands
    Biochem J 336:153-61. 1998
    ..Taken together, these results indicate that Tyr777, Gly778 and Phe780 form part of an atypical tyrosine-based motif, which also requires the presence Leu768 and/or Asn769 to mediate sorting of P-selectin to secretory granules...
  57. ncbi Differential role of E-selectin and P-selectin in T lymphocyte migration to cutaneous inflammatory reactions induced by cytokines
    Anna A Kulidjian
    Department of Immunology, University of Toronto, Toronto, Ontario M5S 1A8, Canada
    Int Immunol 14:751-60. 2002
    ..The relative contribution of the selectins varies depending on the initiating inflammatory stimulus and the genetic background...
  58. ncbi P-, E-, and L-selectin mediate migration of activated CD8+ T lymphocytes into inflamed skin
    Takako Hirata
    Center for Hemostasis and Thrombosis Research, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    J Immunol 169:4307-13. 2002
    ..P- and E-selectin-independent migration of Tc1 cells into the inflamed skin was predominantly mediated by L-selectin. These observations indicate that all three selectins can mediate Tc1 cell migration into the inflamed skin...
  59. pmc The glycoprotein Ib-IX-V complex is a platelet counterreceptor for P-selectin
    G M Romo
    Department of Medicine, Baylor College of Medicine and Veterans Affairs Medical Center, Houston, Texas 77030, USA
    J Exp Med 190:803-14. 1999
    ..Thus, the GP Ib-IX-V complex mediates platelet attachment to both subendothelium and activated endothelium...
  60. ncbi Blood cell dynamics in P-selectin-deficient mice
    R C Johnson
    Center for Blood Research, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Blood 86:1106-14. 1995
    ..Thus, whereas P-selectin is known to be involved in early stages of an inflammatory response, our results indicate that it is additionally responsible for leukocyte rolling and macrophage recruitment in more prolonged tissue injury...
  61. ncbi Platelets and inflammation
    M H Klinger
    Institute of Anatomy, University of Lubeck, Medical School, Germany
    Anat Embryol (Berl) 196:1-11. 1997
    ..On the other hand, the connection between IgE and platelets, besides the platelet-induced eosinophil infiltration, offers a functional basis for the involvement of platelets in allergic processes, particular in the skin and the airways...
  62. pmc Complete reversal of acid-induced acute lung injury by blocking of platelet-neutrophil aggregation
    Alexander Zarbock
    Robert M Berne Cardiovascular Research Center, University of Virginia, Charlottesville, VA 22908 1394, USA
    J Clin Invest 116:3211-9. 2006
    ..The key findings were confirmed in a sepsis-induced model of ALI. These findings may translate into improved clinical treatments for ALI...
  63. ncbi The P-selectin, tissue factor, coagulation triad
    J Polgar
    The CBR Institute for Biomedical Research and Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
    J Thromb Haemost 3:1590-6. 2005
    ..In this review, we discuss the roles of P-sel and TF-positive MPs and highlight strategies to modulate hemostasis by modulating the P-sel, TF, coagulation triad...
  64. ncbi A sulfated peptide segment at the amino terminus of PSGL-1 is critical for P-selectin binding
    D Sako
    Genetics Institute, Small Molecule Drug Discovery Group, Cambridge, Massachusetts 02140, USA
    Cell 83:323-31. 1995
    ..We propose that this sulfotyrosine-containing segment of PSGL-1, in conjunction with sLex presented on O-linked glycans, constitutes the high affinity P-selectin-binding site...
  65. pmc Absence of trauma-induced leukocyte rolling in mice deficient in both P-selectin and intercellular adhesion molecule 1
    E J Kunkel
    Department of Biomedical Engineering, University of Virginia School of Medicine, Charlottesville 22908, USA
    J Exp Med 183:57-65. 1996
    ..This severe defect in leukocyte rolling may explain the absence of leukocyte recruitment into the inflamed peritoneal cavity of P-selectin/ICAM-1-deficient mice at early time points (< or = 4 h)...
  66. pmc Endothelial selectins and vascular cell adhesion molecule-1 promote hematopoietic progenitor homing to bone marrow
    P S Frenette
    The Center for Blood Research, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 95:14423-8. 1998
    ..Optimal recruitment of HPC after lethal doses of irradiation requires the combined action of both selectins and VCAM-1 expressed on endothelium of the BM...
  67. ncbi Direct observation of catch bonds involving cell-adhesion molecules
    Bryan T Marshall
    Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, Georgia 30332, USA
    Nature 423:190-3. 2003
    ..This dual response to force provides a mechanism for regulating cell adhesion under conditions of variable mechanical stress...
  68. ncbi Cloning of the mouse endothelial selectins. Expression of both E- and P-selectin is inducible by tumor necrosis factor alpha
    A Weller
    Hans Spemann Laboratory, Max Planck Institut fur Immunbiologie, Freiburg, Germany
    J Biol Chem 267:15176-83. 1992
    ..While the transport of stored P-selectin to the cell surface is controlled by regulated secretion of storage granules, the synthesis and surface expression can be induced by TNF-alpha similarly to that of E-selectin...
  69. ncbi Different levels of platelet activation in preeclamptic, normotensive pregnant, and nonpregnant women
    Mette R Holthe
    Research Forum, Ullevaal University Hospital, Oslo, Norway
    Am J Obstet Gynecol 190:1128-34. 2004
    ....
  70. ncbi CD24, a mucin-type glycoprotein, is a ligand for P-selectin on human tumor cells
    S Aigner
    Tumor Immunology Programme, German Cancer Research Center, Heidelberg
    Blood 89:3385-95. 1997
    ..The CD24/P-selectin binding pathway could be important in the dissimination of tumor cells by facilitating the interaction with platelets or endothelial cells...
  71. ncbi Structure of the human gene encoding granule membrane protein-140, a member of the selectin family of adhesion receptors for leukocytes
    G I Johnston
    Department of Medicine, St Francis Medical Research Institute, University of Oklahoma Health Sciences Center, Oklahoma City 73104
    J Biol Chem 265:21381-5. 1990
    ..The structure of the GMP-140 gene supports the concept that the selectins evolved as a result of exon duplication and rearrangement...
  72. ncbi Soluble P-selectin as a marker of in vivo platelet activation
    Patrizia Ferroni
    Laboratory of Thrombosis and Haemostasis, Department of Laboratory Medicine and Advanced Biotechnologies, IRCCS San Raffaele, via della Pisana 235, 00163 Rome, Italy
    Clin Chim Acta 399:88-91. 2009
    ..Thus, we investigated whether sP-selectin dosage might reflect platelet function in patients with risk factors for or with established cardiovascular diseases and whether its levels can be modulated by aspirin therapy...
  73. ncbi P-selectin cell adhesion molecule in inflammation, thrombosis, cancer growth and metastasis
    Jian Guo Geng
    Vascular Biology Center and Division of Hematology, Oncology and Transplantation, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    Curr Med Chem 11:2153-60. 2004
    ....
  74. ncbi Role of genetic background in P selectin-dependent immune surveillance of the central nervous system
    Michael D Carrithers
    Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520 0811, USA
    J Neuroimmunol 129:51-7. 2002
    ..Our prior results suggested that early CNS migration of a CD4 Th1 cell line was facilitated by P selectin (CD62P) in (PL/JxSJL/J)F1 mice...
  75. ncbi Mouse P-selectin glycoprotein ligand-1: molecular cloning, chromosomal localization, and expression of a functional P-selectin receptor
    J Yang
    Center for Hemostasis and Thrombosis Research, Division of Hematology Oncology, New England Medical Center, Boston, MA, USA
    Blood 87:4176-86. 1996
    ..PSGL-1 on mouse myeloid cells is critical for high-affinity binding to P-selectin but not E-selectin...
  76. pmc Novel case-control test in a founder population identifies P-selectin as an atopy-susceptibility locus
    Catherine Bourgain
    Department of Human Genetics, University of Chicago, Chicago, IL, USA
    Am J Hum Genet 73:612-26. 2003
    ..10-6) between atopy and an amino acid polymorphism in the P-selectin gene, detected with the QLS test and also, but less significantly (P=.0014), with the transmission/disequilibrium test...
  77. ncbi Susceptibility to infection and altered hematopoiesis in mice deficient in both P- and E-selectins
    P S Frenette
    Center for Blood Research, Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cell 84:563-74. 1996
    ..Our results show that the absence of endothelial selectins severely affects leukocyte homeostasis and indicate that these two selectins are as important for normal leukocyte function as are the leukocyte beta2 integrins...
  78. ncbi Cloning of GMP-140, a granule membrane protein of platelets and endothelium: sequence similarity to proteins involved in cell adhesion and inflammation
    G I Johnston
    St Francis Medical Research Institute, University of Oklahoma Health Sciences Center, Oklahoma City
    Cell 56:1033-44. 1989
    ..This similarity suggests that GMP-140 belongs to a new family of inducible receptors with related structure and function on vascular cells...
  79. ncbi Leukocyte rolling and extravasation are severely compromised in P selectin-deficient mice
    T N Mayadas
    New England Medical Center, Department of Medicine, Boston, Massachusetts
    Cell 74:541-54. 1993
    b>P selectin, expressed on surfaces of activated endothelial cells and platelets, is an adhesion receptor for leukocytes...
  80. pmc Divergent fates of P- and E-selectins after their expression on the plasma membrane
    M Subramaniam
    Department of Medicine, New England Medical Center, Boston, Massachusetts
    Mol Biol Cell 4:791-801. 1993
    ..In summary, after a brief surface exposure, internalized E-selectin is degraded in the lysosomes, whereas P-selectin returns to the storage granules from where it can be reused...
  81. pmc Expression of E-selectin, P-selectin, and intercellular adhesion molecule-1 during experimental murine listeriosis
    S Lopez
    Department of Pathology, Veterinary School, Bellaterra, Barcelona, Spain
    Am J Pathol 155:1391-7. 1999
    ..Up-regulation of P-selectin and ICAM-1 during experimental murine listeriosis could play an important role in the recruitment of leukocytes, especially to the liver, lymphoid organs, and central nervous system...
  82. ncbi Selectin ligand expression regulates the initial vascular interactions of colon carcinoma cells: the roles of CD44v and alternative sialofucosylated selectin ligands
    Susan L Napier
    Department of Chemical and Biomolecular Engineering, The Johns Hopkins University, Baltimore, Maryland 21218, USA
    J Biol Chem 282:3433-41. 2007
    ..Our finding that CD44v is a functional P-selectin ligand on colon carcinoma provides a novel perspective on the enhanced metastatic potential associated with tumor CD44v overexpression and the role of selectins in metastasis...
  83. ncbi Role of P-selectin and intercellular adhesion molecule-1 in TNB-induced colitis in rats
    N Yoshida
    First Department of Internal Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Digestion 63:81-6. 2001
    ..These results suggest that neutrophil-endothelial cell interactions via P-selectin and ICAM-1 play an important role in the development of TNB-induced colitis in rats...
  84. pmc Multiple, targeted deficiencies in selectins reveal a predominant role for P-selectin in leukocyte recruitment
    S D Robinson
    Howard Hughes Medical Institute, Department of Biology, 77 Massachusetts Avenue, Building E17, Room 227, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 96:11452-7. 1999
    ..Data from the ELP(-/-) mice indicate, however, that all three selectins are important to leukocyte homeostasis and efficient neutrophil recruitment...
  85. ncbi Recruitment of adult thymic progenitors is regulated by P-selectin and its ligand PSGL-1
    Fabio M V Rossi
    The Biomedical Research Centre, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada
    Nat Immunol 6:626-34. 2005
    ..Furthermore, the number of resident thymic progenitors controls thymic expression of P-selectin, suggesting that regulation of P-selectin expression by a thymic 'niche occupancy sensor' may be used to direct progenitor access...
  86. pmc P-selectin/ICAM-1 double mutant mice: acute emigration of neutrophils into the peritoneum is completely absent but is normal into pulmonary alveoli
    D C Bullard
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    J Clin Invest 95:1782-8. 1995
    ....
  87. ncbi Molecular determinants of the prothrombogenic and inflammatory phenotype assumed by the postischemic cerebral microcirculation
    Mami Ishikawa
    Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, 1501 Kings Hwy, Shreveport, LA 71130 3932, USA
    Stroke 34:1777-82. 2003
    ..The objective of this study was to define the magnitude and molecular determinants of the platelet- and leukocyte-endothelial cell adhesive interactions induced by I/R in the mouse brain...
  88. ncbi Genomic organization and chromosomal localization of the gene encoding human P-selectin glycoprotein ligand
    G M Veldman
    Small Molecule Drug Discovery Group, Genetics Institute, Cambridge, Massachusetts 02140, USA
    J Biol Chem 270:16470-5. 1995
    ....
  89. ncbi Performance of a panel of maternal serum markers in predicting preeclampsia at 11-15 weeks' gestation
    Irina Banzola
    Department of Embryology Division of Prenatal Medicine, University of Bologna, Bologna, Italy
    Prenat Diagn 27:1005-10. 2007
    ....
  90. ncbi Tyrosine sulfation of P-selectin glycoprotein ligand-1 is required for high affinity binding to P-selectin
    P P Wilkins
    Departments of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City 73190, USA
    J Biol Chem 270:22677-80. 1995
    ..These studies demonstrate that tyrosine sulfate on PSGL-1 functions in conjunction with sialylated and fucosylated glycans to mediate high affinity binding to P-selectin...
  91. ncbi Platelet, not endothelial, P-selectin is required for neointimal formation after vascular injury
    Kai Wang
    Department of Cardiovascular Medicine, Cleveland Clinic Foundation, 9500 Euclid Ave, Cleveland, OH 44195, USA
    Arterioscler Thromb Vasc Biol 25:1584-9. 2005
    ..This study was designed to determine whether P-selectin expression on platelet, endothelial, or both surfaces is critical to the inflammatory response and neointimal formation after arterial injury...
  92. pmc Activated platelets induce Weibel-Palade-body secretion and leukocyte rolling in vivo: role of P-selectin
    Vandana S Dole
    CBR Institute for Biomedical Research, Boston, MA 02115, USA
    Blood 106:2334-9. 2005
    ..We conclude that the presence of activated platelets in circulation promotes acute inflammation by stimulating secretion of Weibel-Palade bodies and P-selectin-mediated leukocyte rolling...
  93. pmc Dynamics of in silico leukocyte rolling, activation, and adhesion
    Jonathan Tang
    The UCSF UCB Joint Graduate Group in Bioengineering, University of California, Berkeley, CA, USA
    BMC Syst Biol 1:14. 2007
    ..The experimentally measured, phenotypic attributes of the analogue were compared and contrasted to those of leukocytes in vitro from three different experimental conditions...
  94. pmc P-selectin deficiency exacerbates experimental glomerulonephritis: a protective role for endothelial P-selectin in inflammation
    A R Rosenkranz
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Clin Invest 103:649-59. 1999
    ..Thus, the protective effect in wild-type mice may be accounted for, in part by soluble P-selectin shed by non-renal endothelial cells, although other endothelial P-selectin-dependent mechanisms cannot be ruled out...
  95. ncbi Platelets adhered to endothelial cell-bound ultra-large von Willebrand factor strings support leukocyte tethering and rolling under high shear stress
    A Bernardo
    Thrombosis Research Section, Department of Medicine, Houston, TX 77030, USA
    J Thromb Haemost 3:562-70. 2005
    ..The observed phenomenon delineates a mechanism for leukocytes to be tethered to arterial endothelial cells under high shear, providing a potential link between inflammation and thrombosis...
  96. ncbi Midazolam attenuates adenosine diphosphate-induced P-selectin expression and platelet-leucocyte aggregation
    C S Tsai
    Department of Surgery Taipei, Tri Service General Hospital, Taiwan, ROC
    Eur J Anaesthesiol 21:871-6. 2004
    ..We have examined the influence of midazolam on adenosine diphosphate (ADP)-induced platelet surface P-selectin expression and platelet-leucocyte aggregation in whole blood...
  97. ncbi Autoperfused mouse flow chamber reveals synergistic neutrophil accumulation through P-selectin and E-selectin
    Michael L Smith
    Department of Biomedical Engineering, University of Virginia, Charlottesville, USA
    J Leukoc Biol 76:985-93. 2004
    ..The unexpected synergism between E- and P-selectins explains why neutrophil recruitment is enhanced when both selectins are expressed...
  98. ncbi Molecular cloning and analysis of in vivo expression of murine P-selectin
    W E Sanders
    Baylor College of Medicine, Department of Internal Medicine, Houston, TX 77030
    Blood 80:795-800. 1992
    ..After administration of endotoxin, the highest levels of mRNA expression were detected in liver, lung, kidney, and heart...
  99. ncbi P-selectin in haemostasis
    Patrick Andre
    Portola Pharmaceuticals, South San Francisco, CA 94080, USA
    Br J Haematol 126:298-306. 2004
    ....
  100. pmc Mechanical switching and coupling between two dissociation pathways in a P-selectin adhesion bond
    Evan Evans
    Department of Biomedical Engineering, Boston University, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 101:11281-6. 2004
    ..The two-pathway switch seems to provide a mechanism for the "catch bond" response observed recently with PSGL-1-P-selectin bonds subjected to small-constant forces...
  101. ncbi Elevation of platelet activation markers and chemokines during peripheral blood stem cell harvest with G-CSF
    Shosaku Nomura
    First Department of Internal Medicine, Kansai Medical University, 10 15 Fumizono cho, Moriguchi, Osaka 570 8507, Japan
    Stem Cells 22:696-703. 2004
    ..Further study is required to determine if a cause-and-effect relationship in their pattern of change exists among them...

Research Grants63

  1. Comprehensive biomarker study to capitalize on existing GWAS in 10K South Asians
    Danish Saleheen; Fiscal Year: 2010
    ..We seek support for additional blood markers to PROMIS by assaying plasma biomarkers potentially relevant to atherogenesis, plaque rupture and/or thrombosis. ..
  2. Comparison of Diesel and Biodiesel Emissions and Health Effects in Underground Mi
    Jefferey L Burgess; Fiscal Year: 2013
    ..Information on the health effects of conversion to biodiesel fuels in occupational and environmental settings will also help to inform future policy decisions. ..
  3. Thiol Isomerases During Thrombus Formation
    Barbara C Furie; Fiscal Year: 2013
    ..abstract_text> ..
  4. Novel Glycosaminoglycan Ethers for Prevention of Metastasis
    Alana L Welm; Fiscal Year: 2011
    ..We propose to develop anionic, partially lipophilic hyaluronic acid derivatives as a synthetic, low anticoagulant, sulfated polysaccharide approach to inhibiting metastatic spread from neoplasms. ..
  5. Homing of Stem Cells in Stroke Therapeutics
    EVAN YALE contact SNYDER; Fiscal Year: 2010
    ..hNSCs following peripheral administration 24 hrs post-stroke, particularly under conditions where their homing has been optimized by fucosylation. ..
  6. Translational studies of the Platelet Specific Receptor Trem Like Transcript (TLT
    A Valance Washington; Fiscal Year: 2013
    ..Our laboratory, having identified TLT-1and developed many TLT-1 reagents is the best suited to delineate TLT-1 function and to translate TLT-1's association with p-selectin from basic biology into clinical significance. ..
  7. The Association of Chronic Exposure to Particulate Matter Air Pollutants, Inflamm
    RODRIGO XAVIER ARMIJOS; Fiscal Year: 2013
    ..The samples will be analyzed using an automated energy dispersive XRF instrument. . ..
  8. Development of an Anti-PSGL-1 Antibody to Treat Crohn's Disease
    Scott A Rollins; Fiscal Year: 2011
    ..S. The drug being developed addresses a major unmet medical need for a therapy that can maintain remission and/or ameliorate the devastating effects of this disease. ..
  9. IMMUNE RESPONSES IN LUPUS
    Joseph Craft; Fiscal Year: 2013
    ..The results of the proposed studies, that utilize a combination of cellular, genetic, and imaging approaches, should help address these issues, and advance knowledge of how normal and autoimmune responses develop in humans. ..
  10. Molecular Imaging of Ischemic Memory with Ultrasound - Transition to Humans
    Jonathan R Lindner; Fiscal Year: 2010
    ..The successful completion of our aims will lead to the development of a new strategy that can be used to more accurately diagnosis life-threatening coronary artery disease. ..
  11. Regulation of Adipose Tissue Inflammation by P-selectin Glycoprotein Ligand-1
    Daniel T Eitzman; Fiscal Year: 2013
    ..Identification of the cellular and molecular mediators of fat inflammation may lead to novel therapeutic agents aimed at reducing the risk of myocardial infarction and stroke in an overweight population. ..
  12. Intracavitary Hemostatic Agent for Non-compressible Hemorrhage
    Martin Bluth; Fiscal Year: 2007
    ..This therapeutic approach will reduce killed in action (KIA) rate, increased life saving capability for the medic, and reduce need for surgery and transfusion. [unreadable] [unreadable] [unreadable]..
  13. Cigarette Smoke Induced Injury in Alveolar Cells in Model Systems
    Charles A Downs; Fiscal Year: 2010
    ....
  14. Cellular Regulation of Selectin-Ligand Interactions
    RODGER PAUL MCEVER; Fiscal Year: 2013
    ..Because excessive recruitment of leukocytes contributes to many diseases, including heart attacks and strokes, understanding how cells regulate adhesion receptors may suggest new therapeutic strategies. ..
  15. Biomechanics of Leukocytes and Molecular Imaging Agents
    MICHAEL BRANDEAU LAWRENCE; Fiscal Year: 2010
    ..Since ultrasound is the most economical of the modern imaging modalities, cost savings in health care can also be expected from the proposed research. ..
  16. The role of neutrophil recruitment in arterial diseases
    Yuqing Huo; Fiscal Year: 2013
    ..These studies will provide evidence that inhibition of neutrophil recruitment to arteries is a viable approach to the prevention and treatment of arterial diseases. ..
  17. Ultrasound mediated targeted therapy for kidney disease
    Joshua J Rychak; Fiscal Year: 2010
    ....
  18. Ethanol Prevents Microvascular Dysfunction
    Ronald J Korthuis; Fiscal Year: 2010
    ....
  19. Quantification and monitoring inflammation in IBD with Molecular Ultrasound
    JUERGEN KARL WILLMANN; Fiscal Year: 2013
    ....
  20. Microparticle Docking in Pancreatic Cancer Induced VTE
    Julia E Geddings; Fiscal Year: 2013
    ..The identification of specific ligand-receptor interactions involved in the docking of pancreatic TMPs to the activated endothelium may lead to the development of novel drugs for preventing cancer-induced VTE. ..
  21. Novel Microparticle Contrast Agent for Near Infrared Molecular Imaging
    Joshua J Rychak; Fiscal Year: 2010
    ..The optical imaging contrast agents described here will enable a substantial increase in the throughput and versatility of optical imaging in the preclinical research setting. ..
  22. Molecular Imaging of Inflammation in Atherosclerosis
    Jonathan R Lindner; Fiscal Year: 2012
    ..abstract_text> ..
  23. Preconditioning Improves Coronary Patency
    Karin Przyklenk; Fiscal Year: 2012
    ..The ultimate goal of our proposal is to obtain novel mechanistic insights that may, in future, be exploited for the design of new treatments for patients at risk of developing thrombotic events. ..
  24. Amyloid-B peptide on endothelial adhesion and its related cellular pathways
    James C M Lee; Fiscal Year: 2010
    ..We use atomic force microscopy to investigate the mechanism underlying the altered adhesion properties of endothelium induced by amyloid beta peptide. The mechanism is important in part of Alzheimer's disease development. ..
  25. Novel Therapeutic Targets for Venous Thromboembolism
    THOMAS WILLIAM WAKEFIELD; Fiscal Year: 2012
    ..abstract_text> ..
  26. Role of complement in brain death induced injury to donor hearts
    Stephen Tomlinson; Fiscal Year: 2010
    ..Determine the effect of anti-complement therapy in the BD donor, the recipient, or both, on the severity of myocardial IRI after heart transplantation and on the development of an alloimmune response and acute rejection of the graft. ..
  27. Selectin-dependent lineage-specific leukocyte recruitment in atherogenesis.
    Jonathon Homeister; Fiscal Year: 2012
    ....
  28. SELECTIN MEDIATED CELL ADHESION UNDER HYDRODYNAMIC SHEAR
    Sriram Neelamegham; Fiscal Year: 2013
    ..In the long run, we anticipate that novel strategies to antagonize selectin-ligand binding interactions will be identified from this work that may aid future drug design. ..
  29. The Thrombin-Thrombomodulin Interaction
    Elizabeth A Komives; Fiscal Year: 2012
    ..Our hope is that by understanding how thrombomodulin alters the activity of thrombin, we may be able to mimic this interaction with better pharmaceuticals that control hemostasis. ..
  30. Mechanisms for Blood Cell Adhesion Under Flow
    RODGER PAUL MCEVER; Fiscal Year: 2012
    ..This information obtained may offer new methods to treat excessive blood cell adhesion in heart attacks, strokes, deep venous thrombosis, and other disorders. ..
  31. Stress and Platelet NPY in Vascular Remodeling
    John W Osborn; Fiscal Year: 2012
    ..This will be the first time that mechanisms of actions of chronic stress on atherosclerotic remodeling will be studied at the cellular-molecular level. ..
  32. Fusing Glycobiology and Nutritional Sciences to Prevent Necrotizing Enterocolitis
    Lars Bode; Fiscal Year: 2009
    ..Our studies will support the efforts to provide formula-fed infants with the same benefits that breast-fed infants receive with their mother's milk. ..
  33. Cancer, venous thromboembolic disease and tissue factor-bearing microparticles
    Bruce Furie; Fiscal Year: 2012
    ..abstract_text> ..
  34. Cardioprotective Effects of Dietary Flavonoids in the Framingham Offspring Cohort
    Paul Jacques; Fiscal Year: 2009
    ....
  35. Novel Platelet Functions in Sepsis and Venous Thromboembolism
    MATTHEW THOMAS RONDINA; Fiscal Year: 2013
    ..These studies may ultimately provide new therapeutic targets to improve our care of patients with sepsis. ..
  36. Sulfated Polysaccharide Derivatives for the Treatment of Rosacea
    NARAYANAM RAO; Fiscal Year: 2009
    ..We propose to develop anionic, partially lipophilic hyaluronic acid derivatives as the first mechanistically-based treatment for this chronic, disfiguring skin disorder. ..
  37. ADHESION MOLECULES IN TRANSFUSION BIOLOGY
    Denisa D Wagner; Fiscal Year: 2010
    ....
  38. Endothelial regulation of IL17 producing T effector cell migration
    MARIA PILAR ALCAIDE ALONSO; Fiscal Year: 2013
    ..abstract_text> ..
  39. Nanoparticles for targeting drug delivery to the injured vascular wall
    Kytai Nguyen; Fiscal Year: 2009
    ..abstract_text> ..
  40. Development of an Anti-P-selectin Antibody for the Treatment of Sickle Cell Disea
    Scott A Rollins; Fiscal Year: 2013
    ....
  41. Regulation of Chronic Viral Infections
    LINDA MAC PHERSON BRADLEY; Fiscal Year: 2013
    ..On the basis of our findings we propose to investigate the mechanisms engaged by PSGL-1 to limit anti-viral immunity and explore therapeutic approaches to target this receptor to enhance anti-viral effector T cell responses ..
  42. Sulfated Polysaccharide Derivatives for Treatment of Macular Degeneration
    Jianxing Zhang; Fiscal Year: 2009
    ..We propose to develop sulfated, partially lipophilic hylauronic acid derivatives as an anti-complement, anti-RAGE, anti-inflammatory and anti-angiogenic therapy for this devastating cause of blindness in older Americans. ..
  43. X-RAYS INDUCE EXOCYTOSIS OF ENDOTHELIAL P-SELECTIN
    Dennis Hallahan; Fiscal Year: 2002
    ..We will study the roles of calcium and calmodulin in the activation of motor proteins that are required for microtubule- dependent translocation of WPB to the cell membrane. ..
  44. HTS assay development for inhibitors of sickle cell
    PAUL FRENETTE; Fiscal Year: 2006
    ..These studies may pave the way to important progress in the treatment or prevention of vasoocclusive episodes in sickle cell disease. ..
  45. CELL ADHESION AND CARBOHYDRATE LIGANDS
    ROGER LAINE; Fiscal Year: 1993
    ..There will be two joint sessions on carbohydrate recognition which promise to bring together the best of current research and investigators in these areas for cross stimulation on these two exciting areas of investigation...
  46. The Regulation of Inflammatory Gene Responses in Aging
    MATTHEW THOMAS RONDINA; Fiscal Year: 2012
    ..Ultimately, this information will provide the basis for novel therapeutic targets for the prevention and treatment of inflammatory and thrombotic disorders in elderly patients. ..
  47. Stability of Severe Asthma Phenotypes: Impact of Exacerbations
    Nizar N Jarjour; Fiscal Year: 2013
    ....
  48. Hematopoietic Stem Cell Therapy for Myocardial Regeneration
    Roberto Bolli; Fiscal Year: 2007
    ..The results may eventually lead to the development of novel therapeutic strategies in patients with ischemic heart disease. ..
  49. PRECONDITIONING: PMN ADHESION AND MICROVASCULAR INJURY
    RONALD KORTHUIS; Fiscal Year: 2003
    ....
  50. SELECTIN MEDIATED LEUKOCYTE ADHESION IN VIVO
    Klaus Ley; Fiscal Year: 2002
    ..The knowledge gained will improve the understanding of the inflammatory process and provide significant information pertinent to the development of potential anti-inflammatory therapies for future clinical use in patients. ..
  51. Multi-analyte Biosensor for Emerging Cardiac Markers
    CHARLES PENNINGTON; Fiscal Year: 2001
    ..The Phase I program has been designed to demonstrate orthogonal confirmation of sensor performance, thus building customer confidence in this novel sensing technology. ..
  52. ISCHEMIA/REPERFUSION INJURY IN SURGERY AND TRAUMA
    Nicholas Vedder; Fiscal Year: 2000
    ..These studies should yield new insights into the basic mechanisms of neutrophil-endothelial interactions in reperfusion injury and potentially suggest new therapeutic strategies to a wide range of important disease processes. ..
  53. Role of Vascular Heterogeneity in Thrombosis
    Barbara Furie; Fiscal Year: 2006
    ..abstract_text> ..
  54. SELECTINS AND HEMATOPOIETIC HOMING AND HOMEOSTASIS
    Michael Long; Fiscal Year: 2000
    ..e., without myeloablation/irradiation). In all these transplantation studies the contribution of WT vs FT-null cells to recipient hematopoiesis is monitored by determining the relative contribution of each to blood leukocyte and ..
  55. Genetic mechanisms which control hematopoietic cell migration
    GEOFFREY KANSAS; Fiscal Year: 2009
    ..Understanding how expression of these sugars is regulated is therefore of high importance to understanding how bone marrow transplantation works as well as related processes. ..
  56. Lung Endothelium in Vaso-Occlusion
    Songwei Wu; Fiscal Year: 2006
    ....
  57. SYSTEMATIC STUDY OF THREE TYPES OF GLYCOSYLTRANSFERASES
    Khushi Matta; Fiscal Year: 2005
    ..As a long term objective, the combination of both inhibitors of critical enzyme for generating human tumor associated antigen and antigens as vaccine may prove beneficial in the treatment of cancer. ..
  58. Selectin Control of Leukocyte Adhesion in Shear
    Michael Lawrence; Fiscal Year: 2006
    ..Such insight may lead to identification of more effective molecular targets for anti-inflammatory therapeutics. ..
  59. SELECTINS ROLE IN VASCULAR INJURY IN GENE-TARGETED
    Ian Sarembock; Fiscal Year: 2004
    ..In addition, these studies will open new avenues to potential therapeutic strategies to limit neointimal growth after vascular injury. ..
  60. AGBD T CELL DEPENDENT MECHANISMS OF GLOMERULONEPHRITIS
    Tanya Mayadas; Fiscal Year: 2006
    ..abstract_text> ..
  61. CHARACTERIZATION OF PLATELET:LEUKOCYTE INTERACTIONS
    THOMAS DIACOVO; Fiscal Year: 2000
    ..The strengths of these laboratories in basic science research plus their interests in disease processes involving adhesion molecules make an ideal environment for training a young investigator. ..
  62. PHTHALOCYANINE PDT--IN VIVO RESPONSES AND MECHANISMS
    Craig Elmets; Fiscal Year: 2004
    ..The long-term goal of these studies is to generate new knowledge regarding the in vivo mechanisms by which PDT works so that it can be used more effectively to treat cancer. ..
  63. Exocytosis and Vascular Inflammation
    Charles Lowenstein; Fiscal Year: 2007
    ..Next we plan to study how specific enzymes reduce oxidized NSF. Finally, we plan to develop a novel class of drugs that decrease vascular inflammation by targeting endothelial cell exocytosis. ..