c type lectins

Summary

Summary: A class of animal lectins that bind to carbohydrate in a calcium-dependent manner. They share a common carbohydrate-binding domain that is structurally distinct from other classes of lectins.

Top Publications

  1. pmc Interleukin 4 potently enhances murine macrophage mannose receptor activity: a marker of alternative immunologic macrophage activation
    M Stein
    Sir William Dunn School of Pathology, Oxford, United Kingdom
    J Exp Med 176:287-92. 1992
  2. pmc DC-SIGN (CD209) mediates dengue virus infection of human dendritic cells
    Boonrat Tassaneetrithep
    Division of Retrovirology, Walter Reed Army Institite of Research and Henry M Jackson Foundation for the Advancement of Military Medicine Diseases, Rockville, MD 20850, USA
    J Exp Med 197:823-9. 2003
  3. ncbi The C-type lectin-like domain superfamily
    Alex N Zelensky
    Computational Proteomics and Therapy Design Group, John Curtin School of Medical Research, Australian National University, Canberra, Australia
    FEBS J 272:6179-217. 2005
  4. ncbi Dendritic cell subsets in health and disease
    Hideki Ueno
    Baylor Institute for Immunology Research, Dallas, TX 75204, USA
    Immunol Rev 219:118-42. 2007
  5. pmc Efficient targeting of protein antigen to the dendritic cell receptor DEC-205 in the steady state leads to antigen presentation on major histocompatibility complex class I products and peripheral CD8+ T cell tolerance
    Laura Bonifaz
    Laboratory of Cellular Physiology and Immunology, The Rockefeller University, New York, NY 10021, USA
    J Exp Med 196:1627-38. 2002
  6. pmc Tumor therapy in mice via antigen targeting to a novel, DC-restricted C-type lectin
    David Sancho
    Immunobiology Laboratory, Cancer Research UK, London Research Institute, London, United Kingdom
    J Clin Invest 118:2098-110. 2008
  7. pmc Identification of a novel population of Langerin+ dendritic cells
    Laura S Bursch
    Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA
    J Exp Med 204:3147-56. 2007
  8. pmc Mycobacteria target DC-SIGN to suppress dendritic cell function
    Teunis B H Geijtenbeek
    Department of Molecular Cell Biology, Vrije Universiteit Medical Center Amsterdam, 1081 BT Amsterdam, Netherlands
    J Exp Med 197:7-17. 2003
  9. pmc CD8+ CD205+ splenic dendritic cells are specialized to induce Foxp3+ regulatory T cells
    Sayuri Yamazaki
    Laboratory of Cellular Physiology and Immunology and Chris Browne Center of Immunology and Immune Disease, The Rockefeller University, New York, NY 10065, USA
    J Immunol 181:6923-33. 2008
  10. pmc In vivo targeting of antigens to maturing dendritic cells via the DEC-205 receptor improves T cell vaccination
    Laura C Bonifaz
    Laboratory of Cellular Physiology and Immunology, Chris Browne Center for Immunology and Immune Diseases, The Rockefeller University, New York, NY 10021, USA
    J Exp Med 199:815-24. 2004

Research Grants

  1. Carole R Mendelson; Fiscal Year: 2016
  2. Inhibiting Mucosal HIV-1 Transmission by Host Cell RNA Interference
    Alexandra L Howell; Fiscal Year: 2013
  3. DC-SIGN Inhibitors for the Treatment of HIV Infection
    ALLEN BERNARD REITZ; Fiscal Year: 2013
  4. Sulfotransferases in the Synthesis of L-Selectin Ligands
    Steven D Rosen; Fiscal Year: 2010
  5. Microenvironmental changes on NK cell responses to primary HSV-1
    Andrew J Tarr; Fiscal Year: 2011
  6. miRNAs and epidermal langerhans cell development and function
    Qing Sheng Mi; Fiscal Year: 2011
  7. Evaluation of the Effects of Chikungunya N-linked Glycosylation on Pathogenesis
    CHARLES EDWIN MCGEE; Fiscal Year: 2013
  8. JEFFREY NEAL WEISER; Fiscal Year: 2016
  9. T1D:Investigating the Gut Microbiome, Urinary Proteome and Metabolome
    Ramana Madupu; Fiscal Year: 2011
  10. Tobias M Hohl; Fiscal Year: 2016

Detail Information

Publications350 found, 100 shown here

  1. pmc Interleukin 4 potently enhances murine macrophage mannose receptor activity: a marker of alternative immunologic macrophage activation
    M Stein
    Sir William Dunn School of Pathology, Oxford, United Kingdom
    J Exp Med 176:287-92. 1992
    ....
  2. pmc DC-SIGN (CD209) mediates dengue virus infection of human dendritic cells
    Boonrat Tassaneetrithep
    Division of Retrovirology, Walter Reed Army Institite of Research and Henry M Jackson Foundation for the Advancement of Military Medicine Diseases, Rockville, MD 20850, USA
    J Exp Med 197:823-9. 2003
    ..Viruses produced by dendritic cells are infectious for DC-SIGN- and L-SIGN-bearing THP-1 cells and other permissive cell lines. Therefore, DC-SIGN may be considered as a new target for designing therapies that block dengue infection...
  3. ncbi The C-type lectin-like domain superfamily
    Alex N Zelensky
    Computational Proteomics and Therapy Design Group, John Curtin School of Medical Research, Australian National University, Canberra, Australia
    FEBS J 272:6179-217. 2005
    ..Recent studies highlight the functional versatility of this protein superfamily and the CTLD scaffold, and suggest further interesting discoveries have yet to be made...
  4. ncbi Dendritic cell subsets in health and disease
    Hideki Ueno
    Baylor Institute for Immunology Research, Dallas, TX 75204, USA
    Immunol Rev 219:118-42. 2007
    ..Alterations of the DC system result in diseases such as autoimmunity, allergy, and cancer. Conversely, DCs can be exploited for vaccination, and novel vaccines that directly target DCs in vivo are being designed...
  5. pmc Efficient targeting of protein antigen to the dendritic cell receptor DEC-205 in the steady state leads to antigen presentation on major histocompatibility complex class I products and peripheral CD8+ T cell tolerance
    Laura Bonifaz
    Laboratory of Cellular Physiology and Immunology, The Rockefeller University, New York, NY 10021, USA
    J Exp Med 196:1627-38. 2002
    ..Therefore, DEC-205 provides an efficient receptor-based mechanism for DCs to process proteins for MHC class I presentation in vivo, leading to tolerance in the steady state and immunity after DC maturation...
  6. pmc Tumor therapy in mice via antigen targeting to a novel, DC-restricted C-type lectin
    David Sancho
    Immunobiology Laboratory, Cancer Research UK, London Research Institute, London, United Kingdom
    J Clin Invest 118:2098-110. 2008
    ..We conclude that DNGR-1 is a novel, highly specific marker of mouse and human DC subsets that can be exploited for CTL cross-priming and tumor therapy...
  7. pmc Identification of a novel population of Langerin+ dendritic cells
    Laura S Bursch
    Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA
    J Exp Med 204:3147-56. 2007
    ..This suggests that dermal LCs can mediate CHS and provides an explanation for previous differences observed in the two-model systems...
  8. pmc Mycobacteria target DC-SIGN to suppress dendritic cell function
    Teunis B H Geijtenbeek
    Department of Molecular Cell Biology, Vrije Universiteit Medical Center Amsterdam, 1081 BT Amsterdam, Netherlands
    J Exp Med 197:7-17. 2003
    ..Moreover, we demonstrate that DC-SIGN has a broader pathogen recognition profile than previously shown, suggesting that DC-SIGN may represent a molecular target for clinical intervention in infections other than HIV-1...
  9. pmc CD8+ CD205+ splenic dendritic cells are specialized to induce Foxp3+ regulatory T cells
    Sayuri Yamazaki
    Laboratory of Cellular Physiology and Immunology and Chris Browne Center of Immunology and Immune Disease, The Rockefeller University, New York, NY 10065, USA
    J Immunol 181:6923-33. 2008
    ..Targeting of Ag to these DCs might be useful for inducing Ag-specific Foxp3(+) Treg for treatment of autoimmune diseases, transplant rejection, and allergy...
  10. pmc In vivo targeting of antigens to maturing dendritic cells via the DEC-205 receptor improves T cell vaccination
    Laura C Bonifaz
    Laboratory of Cellular Physiology and Immunology, Chris Browne Center for Immunology and Immune Diseases, The Rockefeller University, New York, NY 10021, USA
    J Exp Med 199:815-24. 2004
    ....
  11. ncbi Type 1 and type 2 cytokine regulation of macrophage endocytosis: differential activation by IL-4/IL-13 as opposed to IFN-gamma or IL-10
    L J Montaner
    The Wistar Institute, Philadelphia, PA 19104, USA
    J Immunol 162:4606-13. 1999
    ..In summary, our data document differential effects on macrophage endocytic functions by type 1 or type 2 cytokines associated with induction and effector pathways in immunity...
  12. ncbi C-type lectin DC-SIGN modulates Toll-like receptor signaling via Raf-1 kinase-dependent acetylation of transcription factor NF-kappaB
    Sonja I Gringhuis
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, 1007 MB Amsterdam, The Netherlands
    Immunity 26:605-16. 2007
    ..Thus, this pathway is involved in regulation of adaptive immunity by DCs to bacterial, fungal, and viral pathogens...
  13. ncbi Epidermal viral immunity induced by CD8alpha+ dendritic cells but not by Langerhans cells
    Rhys S Allan
    Department of Microbiology and Immunology, The University of Melbourne, Melbourne, Victoria 3010, Australia
    Science 301:1925-8. 2003
    ..Thus, the traditional view of Langerhans cells in epidermal immunity needs to be revisited to accommodate a requirement for other dendritic cells in this response...
  14. ncbi The C-type lectin DC-SIGN (CD209) is an antigen-uptake receptor for Candida albicans on dendritic cells
    Alessandra Cambi
    Department of Tumor Immunology, Nijmegen Center for Molecular Life Sciences, University Medical Center Nijmegen, Nijmegen, The Netherlands
    Eur J Immunol 33:532-8. 2003
    ..albicans receptor expressed by DC. Together, these results demonstrate that DC-SIGN is an exquisite pathogen-uptake receptor that captures not only viruses but also fungi...
  15. ncbi Differential antigen processing by dendritic cell subsets in vivo
    Diana Dudziak
    Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10021, USA
    Science 315:107-11. 2007
    ..This difference in antigen processing is intrinsic to the DC subsets and is associated with increased expression of proteins involved in MHC processing...
  16. pmc Blood-derived dermal langerin+ dendritic cells survey the skin in the steady state
    Florent Ginhoux
    Department of Gene and Cell Medicine, Mount Sinai School of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Exp Med 204:3133-46. 2007
    ..We propose that this is an important and previously unappreciated element of immunosurveillance that needs to be taken into account in the design of novel vaccine strategies...
  17. ncbi The receptor DEC-205 expressed by dendritic cells and thymic epithelial cells is involved in antigen processing
    W Jiang
    Laboratory of Molecular Immunology, Rockefeller University, New York, New York 10021, USA
    Nature 375:151-5. 1995
    ..Thus DEC-205 is a novel endocytic receptor that can be used by dendritic cells and thymic epithelial cells to direct captured antigens from the extracellular space to a specialized antigen-processing compartment...
  18. ncbi Human diversity in killer cell inhibitory receptor genes
    M Uhrberg
    Department of Structural Biology, Stanford University School of Medicine, California 94305, USA
    Immunity 7:753-63. 1997
    ..Group B comprises more noninhibitory KIR genes and contains at least one additional gene not represented in group A. The KIR locus therefore appears to be polygenic and polymorphic within the human population...
  19. ncbi The dendritic cell-specific adhesion receptor DC-SIGN internalizes antigen for presentation to T cells
    Anneke Engering
    Department of Molecular Cell Biology, Vrye Universiteit Medical Center, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
    J Immunol 168:2118-26. 2002
    ..These data point to a novel function of the adhesion receptor DC-SIGN as an efficient DC-specific Ag receptor that can be used as a target to induce viral and antitumor immunity...
  20. doi Origin, homeostasis and function of Langerhans cells and other langerin-expressing dendritic cells
    Miriam Merad
    Department of Gene and Cell Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    Nat Rev Immunol 8:935-47. 2008
    ..In this Review we describe new developments in the understanding of the biology of LCs and other langerin(+) DCs and discuss the challenges that remain in identifying the role of different DC subsets in tissue immunity...
  21. ncbi Dynamics and function of Langerhans cells in vivo: dermal dendritic cells colonize lymph node areas distinct from slower migrating Langerhans cells
    Adrien Kissenpfennig
    Centre d immunologie de Marseille Luminy, INSERM CNRS Universite de la Mediterranee, Parc Scientifique et Technologique de Luminy, Case 906, 13288 Marseille Cedex 09, France
    Immunity 22:643-54. 2005
    ..By using a similar knockin strategy involving a diphtheria toxin receptor (DTR) fused to EGFP, we demonstrated that LCs were dispensable for triggering hapten-specific T cell effectors through skin immunization...
  22. pmc Inducible ablation of mouse Langerhans cells diminishes but fails to abrogate contact hypersensitivity
    Clare L Bennett
    Department of Cell Biology and Histology, Academic Medical Center AMC, University of Amsterdam, 1105 AZ Amsterdam, Netherlands
    J Cell Biol 169:569-76. 2005
    ..Our results establish Langerin-DTR mice as a unique tool to study LC function in the steady state and to explore their relative importance compared with dDC in orchestrating skin immunity and tolerance...
  23. pmc The human macrophage mannose receptor directs Mycobacterium tuberculosis lipoarabinomannan-mediated phagosome biogenesis
    Peter B Kang
    Division of Infectious Diseases, Department of Internal Medicine, Center for Microbial Interface Biology, The Ohio State University, Columbus, OH 43210, USA
    J Exp Med 202:987-99. 2005
    ..0 +/- 5.1% vs. 38.6 +/- 0.6%). Thus, engagement of the MR by ManLAM during the phagocytic process directs M.tb to its initial phagosomal niche, thereby enhancing survival in human macrophages...
  24. ncbi The carbohydrate-recognition domain of Dectin-2 is a C-type lectin with specificity for high mannose
    Eamon P McGreal
    Sir William Dunn School of Pathology, Oxford University, Oxford OX1 3RE, UK
    Glycobiology 16:422-30. 2006
    ....
  25. ncbi How C-type lectins detect pathogens
    Alessandra Cambi
    Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University, Nijmegen, The Netherlands
    Cell Microbiol 7:481-8. 2005
    ..Moreover, the cross-talk of C-type lectins with other receptors, such as Toll-like receptors, will be discussed, highlighting the emerging model that microbial recognition is based on a complex network of interacting receptors...
  26. doi Dcir deficiency causes development of autoimmune diseases in mice due to excess expansion of dendritic cells
    Noriyuki Fujikado
    Center for Experimental Medicine, The Institute of Medical Science, The University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Nat Med 14:176-80. 2008
    ..These observations indicate that Dcir is a negative regulator of DC expansion and has a crucial role in maintaining the homeostasis of the immune system...
  27. ncbi Functionally and structurally distinct NK cell receptor repertoires in the peripheral blood of two human donors
    N M Valiante
    Department of Structural Biology, Stanford University School of Medicine, California 94305, USA
    Immunity 7:739-51. 1997
    ..Because of these differences, the first donor has subpopulations of NK cells that kill cells of the second donor, whereas the NK cells of the second donor are universally tolerant of cells from the first donor...
  28. ncbi Specific and nonspecific NK cell activation during virus infection
    A O Dokun
    Howard Hughes Medical Institute, Rheumatology Division, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA
    Nat Immunol 2:951-6. 2001
    ..These findings indicated that Ly49H+ NK cells were specifically activated by MCMV and that MCMV infection was characterized by nonspecific and specific phases of NK cell activation in vivo...
  29. ncbi Langerin, a novel C-type lectin specific to Langerhans cells, is an endocytic receptor that induces the formation of Birbeck granules
    J Valladeau
    Schering Plough Laboratory for Immunological Research, Dardilly, France
    Immunity 12:71-81. 2000
    ..Our data suggest that induction of BG is a consequence of the antigen-capture function of Langerin, allowing routing into these organelles and providing access to a nonclassical antigen-processing pathway...
  30. ncbi Characterization of the murine macrophage mannose receptor: demonstration that the downregulation of receptor expression mediated by interferon-gamma occurs at the level of transcription
    N Harris
    Division of Hematology Oncology, Children s Hospital, Boston, MA 02115
    Blood 80:2363-73. 1992
    ..Therefore, the regulation of mannose receptor expression by IFN-gamma provides a novel system in which to study the mechanisms by which this cytokine represses gene expression...
  31. ncbi In vivo developmental stages in murine natural killer cell maturation
    Sungjin Kim
    Howard Hughes Medical Institute and Rheumatology Division, Department of Internal Medicine, Barnes Jewish Hospital and Washington University School of Medicine, St Louis, MO 63110, USA
    Nat Immunol 3:523-8. 2002
    ....
  32. ncbi Functional interactions between dendritic cells and NK cells during viral infection
    Daniel M Andrews
    Department of Microbiology, School of Biomedical and Chemical Sciences, The University of Western Australia, Nedlands, Perth, Australia
    Nat Immunol 4:175-81. 2003
    ..This study provides evidence for a functional interrelationship between DCs and NK cells during viral infection and defines some of the critical cytokines...
  33. ncbi DC-SIGN: a novel HIV receptor on DCs that mediates HIV-1 transmission
    T B H Geijtenbeek
    Department of Molecular Cell Biology, Vrije Universiteit Medical Center Amsterdam, Van de Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
    Curr Top Microbiol Immunol 276:31-54. 2003
    ....
  34. ncbi Epidermal langerhans cell-deficient mice develop enhanced contact hypersensitivity
    Daniel H Kaplan
    Department of Dermatology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Immunity 23:611-20. 2005
    ..Moreover, we showed that LCs act during the priming and not the effector phase. Thus, LCs not only were dispensable for CHS, but they served to regulate the response, a previously unappreciated function...
  35. pmc Dendritic-cell interactions with HIV: infection and viral dissemination
    Li Wu
    Department of Microbiology and Molecular Genetics, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, Wisconsin 53226, USA
    Nat Rev Immunol 6:859-68. 2006
    ..This Review highlights the latest advances in our understanding of the interactions between DCs and HIV, focusing on the mechanisms of DC-mediated viral dissemination...
  36. ncbi Human cytomegalovirus binding to DC-SIGN is required for dendritic cell infection and target cell trans-infection
    Franck Halary
    Laboratoire d Immunologie, CNRS UMR 5540, Universite Bordeaux 2, France
    Immunity 17:653-64. 2002
    ..These results provide new insights into the molecular interactions contributing to cell infection by CMV and extend DC-SIGN implication in virus propagation...
  37. ncbi Plasmacytoid dendritic cells: from specific surface markers to specific cellular functions
    Andrzej Dzionek
    Miltenyi Biotec, Bergisch Gladbach, Germany
    Hum Immunol 63:1133-48. 2002
    ..In blood and bone marrow, BDCA-4/NP-1 is exclusively expressed on PDCs, but in tonsils also on a few other cells, primarily follicular B helper memory T cells (T(FH))...
  38. pmc DC-SIGN and DC-SIGNR interact with the glycoprotein of Marburg virus and the S protein of severe acute respiratory syndrome coronavirus
    Andrea Marzi
    Institute for Clinical and Molecular Virology, University Erlangen Nurnberg, Nikolaus Fiebiger Center, Glückstrasse 6, D 91054 Erlangen, Germany
    J Virol 78:12090-5. 2004
    ..SIGNR1, a murine DC-SIGN homologue, also enhanced infection driven by MARV and Ebola virus GP and could be targeted to assess the role of attachment factors in filovirus infection in vivo...
  39. ncbi Syk-dependent cytokine induction by Dectin-1 reveals a novel pattern recognition pathway for C type lectins
    Neil C Rogers
    Immunobiology Laboratory, Cancer Research UK, London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3PX, United Kingdom
    Immunity 22:507-17. 2005
    ..These results identify a novel signaling pathway involved in pattern recognition by C type lectins and suggest a potential role for Syk kinase in regulation of innate immunity.
  40. ncbi Specificity of DC-SIGN for mannose- and fucose-containing glycans
    Ellis Van Liempt
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, Van der Boechorstsraat 7, 1081 BT Amsterdam, The Netherlands
    FEBS Lett 580:6123-31. 2006
    ..These results demonstrate that DC-SIGN is selective in its recognition of specific types of fucosylated glycans and subsets of oligomannose- and complex-type N-glycans...
  41. ncbi Cloning of a novel C-type lectin expressed by murine macrophages
    S G Balch
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, United Kingdom
    J Biol Chem 273:18656-64. 1998
    ..The mcl gene locus has been mapped between the genes for the interleukin-17 receptor and CD4 on mouse chromosome 6, the same chromosome as the mouse natural killer cell gene complex...
  42. ncbi A novel LPS-inducible C-type lectin is a transcriptional target of NF-IL6 in macrophages
    M Matsumoto
    Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Japan
    J Immunol 163:5039-48. 1999
    ..The Mincle gene locus was mapped at 0.6 centiMorgans proximal to CD4 on mouse chromosome 6...
  43. ncbi Identification of DC-SIGN, a novel dendritic cell-specific ICAM-3 receptor that supports primary immune responses
    T B Geijtenbeek
    Department of Tumor Immunology, University Medical Center St Radboud, Nijmegen, The Netherlands
    Cell 100:575-85. 2000
    ..Since antibodies against DC-SIGN inhibit DC-induced proliferation of resting T cells, our findings predict that DC-SIGN enables T cell receptor engagement by stabilization of the DC-T cell contact zone...
  44. pmc A dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin (DC-SIGN)-related protein is highly expressed on human liver sinusoidal endothelial cells and promotes HIV-1 infection
    A A Bashirova
    Laboratory of Genomic Diversity, Science Applications International Corporation Frederick, Frederick, MD 21702, USA
    J Exp Med 193:671-8. 2001
    ..We propose that L-SIGN may play an important role in the interaction between liver sinusoidal endothelium and trafficking lymphocytes, as well as function in the pathogenesis of HIV-1...
  45. ncbi Versican is upregulated in CNS injury and is a product of oligodendrocyte lineage cells
    Richard A Asher
    Physiological Laboratory, University of Cambridge, Downing Site, Cambridge CB2 3EG, United Kingdom
    J Neurosci 22:2225-36. 2002
    ..Because large numbers of OLCs are recruited to CNS lesions, these results suggest that OLC-derived versican contributes to the inhospitable environment of the injured CNS...
  46. ncbi Functional characterization of mannose receptor expressed by immunocompetent mouse microglia
    Heiko Zimmer
    Department of Neurobiology, University of Heidelberg, Germany
    Glia 42:89-100. 2003
    ..Together, these observations demonstrate that cytokine-stimulated immunocompetent microglia express a functional mannose receptor...
  47. ncbi Cis association of Ly49A with MHC class I restricts natural killer cell inhibition
    Marie Agnès Doucey
    Institute of Biochemistry, University of Lausanne, Ch des Boveresses 155, 1066 Epalinges, Switzerland
    Nat Immunol 5:328-36. 2004
    ..By lowering the threshold at which NK cell activation exceeds NK cell inhibition, cis interaction allows optimal discrimination of normal and abnormal host cells...
  48. pmc Langerhans cells utilize CD1a and langerin to efficiently present nonpeptide antigens to T cells
    Robert E Hunger
    Division of Dermatology, Department of Medicine, David Geffen School of Medicine at the University of California, Los Angeles UCLA, Los Angeles, California 90095, USA
    J Clin Invest 113:701-8. 2004
    ..LCs in leprosy lesions coexpress CD1a and langerin, placing LCs in position to efficiently present a subset of antigens to T cells as part of the host response to human infectious disease...
  49. pmc TLR activation triggers the rapid differentiation of monocytes into macrophages and dendritic cells
    Stephan R Krutzik
    Division of Dermatology, University of California at Los Angeles, 611 Charles Young Drive East, 536 Boyer Hall, Los Angeles, CA 90095, USA
    Nat Med 11:653-60. 2005
    ..Thus, TLR-induced differentiation of monocytes into either macrophages or dendritic cells seems to crucially influence effective host defenses in human infectious disease...
  50. ncbi Phospholipase C-gamma 2 is a critical signaling mediator for murine NK cell activating receptors
    Ilaria Tassi
    Department of Pathology and Immunology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    J Immunol 175:749-54. 2005
    ..These results demonstrate that PLCgamma2 is crucial for development of the NK cell receptor repertoire and signaling of activating NK cell receptors, mediating optimal NK cell function in vivo...
  51. ncbi Polymorphisms in human langerin affect stability and sugar binding activity
    Eliot M Ward
    Glycobiology Institute, Department of Biochemistry, University of Oxford, Oxford OX1 3QU, United Kingdom
    J Biol Chem 281:15450-6. 2006
    ..These findings suggest that certain langerin haplotypes may differ in their binding to pathogens and thus might be associated with susceptibility to infection...
  52. pmc Symbiotic bacteria direct expression of an intestinal bactericidal lectin
    Heather L Cash
    Center for Immunology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Science 313:1126-30. 2006
    ..We propose that these proteins represent an evolutionarily primitive form of lectin-mediated innate immunity, and that they reveal intestinal strategies for maintaining symbiotic host-microbial relationships...
  53. ncbi Cutting edge: langerin/CD207 receptor on dendritic cells mediates efficient antigen presentation on MHC I and II products in vivo
    Juliana Idoyaga
    Laboratory of Cellular Physiology and Immunology, Chris Browne Center for Immunology and Immune Diseases, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA
    J Immunol 180:3647-50. 2008
    ..Peptide MHC I and II complexes persist for days. Dose response studies indicate only modest differences between Langerin and DEC receptors in these functions. Thus, Langerin effectively mediates Ag presentation...
  54. ncbi Costimulation of dectin-1 and DC-SIGN triggers the arachidonic acid cascade in human monocyte-derived dendritic cells
    Isela Valera
    Instituto de Biologia y Genetica Molecular, Consejo Superior de Investigaciones Cientificas, Universidad de Valladolid, Valladolid, Spain
    J Immunol 180:5727-36. 2008
    ..These findings help explain the distinct functional properties of DC matured by immune complexes vs those matured by beta-glucans...
  55. ncbi The macrophage-inducible C-type lectin, mincle, is an essential component of the innate immune response to Candida albicans
    Christine A Wells
    National Centre for Adult Stem Cell Research, Eskitis Institute for Cell and Molecular Therapies, Griffith University, Brisbane, Queensland, Australia
    J Immunol 180:7404-13. 2008
    ..In addition, mice lacking Mincle showed a significantly increased susceptibility to systemic candidiasis. Thus, Mincle plays a novel and nonredundant role in the induction of inflammatory signaling in response to C. albicans infection...
  56. doi Reg IV is an independent prognostic factor for relapse in patients with clinically localized prostate cancer
    Shinya Ohara
    Department of Molecular Pathology, Hiroshima Graduate School of Biomedical Sciences, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    Cancer Sci 99:1570-7. 2008
    ..In the LNCaP cell line, EGFR phosphorylation was induced by the addition of Reg IV-conditioned medium. These results suggest that Reg IV expression is an independent prognostic indicator of relapse after radical prostatectomy...
  57. doi Characterization of murine MGL1 and MGL2 C-type lectins: distinct glycan specificities and tumor binding properties
    Satwinder Kaur Singh
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands
    Mol Immunol 46:1240-9. 2009
    ..Strikingly, MGL2 interacted strongly to adenocarcinoma cells, suggesting a potential role in tumor immunity...
  58. pmc DC-SIGNR, a DC-SIGN homologue expressed in endothelial cells, binds to human and simian immunodeficiency viruses and activates infection in trans
    S Pohlmann
    Department of Pathology and Laboratory Medicine, University of Pennsylvania, 806 Abramson, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 98:2670-5. 2001
    ....
  59. pmc Functional interaction of common allergens and a C-type lectin receptor, dendritic cell-specific ICAM3-grabbing non-integrin (DC-SIGN), on human dendritic cells
    Shih Chang Hsu
    Johns Hopkins Asthma and Allergy Center, Baltimore, Maryland 21224, USA
    J Biol Chem 285:7903-10. 2010
    ..These results suggest that allergens are able to interact with DC-SIGN and induce tumor necrosis factor-alpha expression in MDDCs via, in part, Raf-1 signaling pathways...
  60. ncbi Natural killer cell receptors in the horse: evidence for the existence of multiple transcribed LY49 genes
    Tomoko Takahashi
    Department of Biosystems Science, School of Advanced Sciences, The Graduate University for Advanced Studies Sokendai, Hayama, Japan
    Eur J Immunol 34:773-84. 2004
    ..We also show that horse spleen expresses ILT-like genes with unique domain organizations. Radiation hybrid mapping and fluorescence in situ hybridization localized horse LY49 and KIR/ILT genes to chromosomes 6q13 and 10p12, respectively...
  61. ncbi The molecular basis for the immunogenicity of Cryptococcus neoformans mannoproteins
    Stuart M Levitz
    Department of Medicine, Boston Medical Center and Boston University School of Medicine, Boston, MA 02118, USA
    FEMS Yeast Res 6:513-24. 2006
    ..Inhibition of mannose receptors or deglycosylation of mannoproteins profoundly inhibits T-cell responses, demonstrating the crucial contribution of mannosylation to immunogenicity...
  62. ncbi Distinct roles for DC-SIGN+-dendritic cells and Langerhans cells in HIV-1 transmission
    Lot de Witte
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands
    Trends Mol Med 14:12-9. 2008
    ..Here, we will discuss the molecular mechanisms involved in HIV-1 transmission and viral clearance. A better understanding of these processes is crucial to understand and develop strategies to combat transmission...
  63. pmc Dendritic cells induce peripheral T cell unresponsiveness under steady state conditions in vivo
    D Hawiger
    Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10021, USA
    J Exp Med 194:769-79. 2001
    ..We conclude that in the absence of additional stimuli DCs induce transient antigen-specific T cell activation followed by T cell deletion and unresponsiveness...
  64. ncbi DC-SIGN and DC-SIGNR bind ebola glycoproteins and enhance infection of macrophages and endothelial cells
    Graham Simmons
    Department of Molecular Histopathology, University of Cambridge, Cambridge, CB2 1QP, United Kingdom
    Virology 305:115-23. 2003
    ....
  65. ncbi Characterization of carbohydrate recognition by langerin, a C-type lectin of Langerhans cells
    Nicola S Stambach
    Glycobiology Institute, Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK
    Glycobiology 13:401-10. 2003
    ..The results are consistent with a role for langerin in internalization of both self and nonself glycoprotein antigens...
  66. pmc Human macrophage C-type lectin specific for galactose and N-acetylgalactosamine promotes filovirus entry
    Ayato Takada
    Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo 108 8639, Japan
    J Virol 78:2943-7. 2004
    ..We propose that filoviruses use different C-type lectins to gain cellular entry, depending on the cell type, and promote efficient viral replication...
  67. ncbi Association of arthritis with a gene complex encoding C-type lectin-like receptors
    Johnny C Lorentzen
    Department of Medicine, Rheumatology Unit, Karolinska Institutet, Karolinska University Hospital, S 17176 Stockholm, Sweden
    Arthritis Rheum 56:2620-32. 2007
    ..To identify susceptibility genes in a rat model of rheumatoid arthritis (RA) and to determine whether the corresponding human genes are associated with RA...
  68. ncbi Dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin mediates binding and internalization of Aspergillus fumigatus conidia by dendritic cells and macrophages
    Diego Serrano-Gomez
    Centro de Investigaciones Biologicas, Consejo Superior de Investigaciones Cientificas, Madrid, Spain
    J Immunol 173:5635-43. 2004
    ..Our results suggest the involvement of DC-SIGN in the initial stages of pulmonary infection as well as in fungal spreading during invasive aspergillosis...
  69. ncbi Mannose receptor-targeted vaccines
    Tibor Keler
    Medarex, Inc, 519 Route 173 West, Bloomsbury, NJ 08804, USA
    Expert Opin Biol Ther 4:1953-62. 2004
    ....
  70. ncbi RANTES -28G delays and DC-SIGN - 139C enhances AIDS progression in HIV type 1-infected Japanese hemophiliacs
    Yusuke Koizumi
    Department of Viral Infection and International Health, Graduate School of Medical Science, Kanazawa University, Kanazawa 920 8640, Japan
    AIDS Res Hum Retroviruses 23:713-9. 2007
    ..These results suggest that RANTES -28G was associated with delayed AIDS progression, while DC-SIGN -139C was associated with accelerated AIDS progression in HIV-1-infected Japanese hemophiliacs...
  71. ncbi APCs express DCIR, a novel C-type lectin surface receptor containing an immunoreceptor tyrosine-based inhibitory motif
    E E Bates
    Laboratory for Immunological Research, Schering Plough, Dardilly, France
    J Immunol 163:1973-83. 1999
    ..DCIR represents a novel surface molecule expressed by Ag presenting cells, and of potential importance in regulation of DC function...
  72. pmc C-type lectins DC-SIGN and L-SIGN mediate cellular entry by Ebola virus in cis and in trans
    Carmen P Alvarez
    Laboratory of Molecular Microbiology, Dept of Microbiology, Hospital 12 de Octubre, 28041 Madrid, Spain
    J Virol 76:6841-4. 2002
    ..Our data underscore a role for DC-SIGN and L-SIGN in the infective process and pathogenicity of Ebola virus infection...
  73. ncbi Involvement of macrophage mannose receptor in the binding and transmission of HIV by macrophages
    Deborah Greene Nguyen
    Department of Pharmacology, Johns Hopkins School of Medicine, Baltimore, USA
    Eur J Immunol 33:483-93. 2003
    ..Together, these results suggest a substantial role for MMR in the binding and transmission of HIV-1 by macrophages...
  74. ncbi Pattern recognition receptors and differentiation antigens define murine myeloid cell heterogeneity ex vivo
    Philip R Taylor
    Sir William Dunn School of Pathology, Oxford University, Oxford, GB
    Eur J Immunol 33:2090-7. 2003
    ....
  75. pmc Dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin/CD209 is abundant on macrophages in the normal human lymph node and is not required for dendritic cell stimulation of the mixed leukocyte reaction
    Angela Granelli-Piperno
    Laboratory of Cellular Physiology and Immunology and Chris Browne Center for Immunology and Immune Diseases, Rockefeller University, New York, NY 10021, USA
    J Immunol 175:4265-73. 2005
    ..These results indicate that DC-SIGN has the potential to contribute to macrophage function in normal human lymph node, and that DCs do not require DC-SIGN to transmit HIV or to initiate T cell responses...
  76. ncbi DC-SIGN (CD209), pentraxin 3 and vitamin D receptor gene variants associate with pulmonary tuberculosis risk in West Africans
    R Olesen
    MRC Laboratories, Banjul, The Gambia
    Genes Immun 8:456-67. 2007
    ..78, 95% CI 0.63-0.98). Our findings support previous data showing that VDR SNPs modulate the risk for TB in West Africans and suggest that variation within DC-SIGN and PTX3 also affect the disease outcome...
  77. ncbi DC-SIGN, a C-type lectin on dendritic cells that unveils many aspects of dendritic cell biology
    Teunis B H Geijtenbeek
    Department of Molecular Cell Biology, Vrije Universiteit Medical Center Amsterdam, The Netherlands
    J Leukoc Biol 71:921-31. 2002
    ..Here we discuss the carbohydrate/protein recognition profile and other features of DC-SIGN that contribute to the potency of DC to control immunity...
  78. ncbi DC-SIGN; a related gene, DC-SIGNR; and CD23 form a cluster on 19p13
    E J Soilleux
    Immunology, Department of Pathology, Cambridge University, United Kingdom
    J Immunol 165:2937-42. 2000
    ..The existence of a DC-SIGN-related gene calls for reinterpretation of the HIV data to consider possible DC-SIGN/DC-SIGNR hetero-oligomerization...
  79. pmc A signal peptide derived from hsp60 binds HLA-E and interferes with CD94/NKG2A recognition
    Jakob Michaelsson
    Microbiology and Tumor Biology Center, Karolinska Institutet, 171 77 Stockholm, Sweden
    J Exp Med 196:1403-14. 2002
    ..Such stress induced peptide interference would gradually uncouple CD94/NKG2A inhibitory recognition and provide a mechanism for NK cells to detect stressed cells in a peptide-dependent manner...
  80. ncbi Targeting of antigens to activated dendritic cells in vivo cures metastatic melanoma in mice
    Karsten Mahnke
    Department of Dermatology, University of Heidelberg, Heidelberg, Germany
    Cancer Res 65:7007-12. 2005
    ..Thus, these data show that targeting of dendritic cells in situ by the means of antibody-antigen conjugates may be a novel way to induce long-lasting antitumor immunity...
  81. ncbi Myeloid C-type lectins in innate immunity
    Matthew J Robinson
    Immunobiology Laboratory, Cancer Research UK, London Research Institute, London WC2A 3PX, United Kingdom
    Nat Immunol 7:1258-65. 2006
    ..Here we focus on the known signaling pathways of myeloid C-type lectins and on their possible functions as autonomous activating or inhibitory receptors involved in innate responses to pathogens or self...
  82. pmc The mannose receptor mediates uptake of pathogenic and nonpathogenic mycobacteria and bypasses bactericidal responses in human macrophages
    C Astarie-Dequeker
    Institut de Pharmacologie et de Biologie Structurale, Centre National de la Recherche Scientifique, UPR 9062, 31077 Toulouse, France
    Infect Immun 67:469-77. 1999
    ..In conclusion, MR-dependent phagocytosis is coupled neither to the activation of NADPH oxidase nor to the maturation of phagosomes until fusion with the Hck compartment and therefore constitutes a safe portal of entry for microorganisms...
  83. ncbi Cross-linking of the mannose receptor on monocyte-derived dendritic cells activates an anti-inflammatory immunosuppressive program
    Marcello Chieppa
    Department of Immunology, Istituto Mario Negri, Milan, Italy
    J Immunol 171:4552-60. 2003
    ....
  84. pmc Pneumocystis activates human alveolar macrophage NF-kappaB signaling through mannose receptors
    Jianmin Zhang
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Infect Immun 72:3147-60. 2004
    ....
  85. pmc Promoter variation in the DC-SIGN-encoding gene CD209 is associated with tuberculosis
    Luis B Barreiro
    CNRS FRE2849, Unit of Molecular Prevention and Therapy of Human Diseases, Institut Pasteur, Paris, France
    PLoS Med 3:e20. 2006
    ..We reasoned that if DC-SIGN interacts with M. tuberculosis, as well as with other pathogens, variation in this gene might have a broad range of influence in the pathogenesis of a number of infectious diseases, including tuberculosis...
  86. ncbi Langerin is a natural barrier to HIV-1 transmission by Langerhans cells
    Lot de Witte
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, van de Boechorstraat 7, 1081BT Amsterdam, The Netherlands
    Nat Med 13:367-71. 2007
    ..Thus Langerin is a natural barrier to HIV-1 infection, and strategies to combat infection must enhance, preserve or, at the very least, not interfere with Langerin expression and function...
  87. pmc Renal cells activate the platelet receptor CLEC-2 through podoplanin
    Charita M Christou
    Henry Wellcome Building for Molecular Physiology, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK
    Biochem J 411:133-40. 2008
    ..The interaction has an affinity of 24.5+/-3.7 microM. The present study identifies podoplanin as a ligand for CLEC-2 on renal cells...
  88. doi Signalling through C-type lectin receptors: shaping immune responses
    Teunis B H Geijtenbeek
    Academic Medical Center, University of Amsterdam, The Netherlands
    Nat Rev Immunol 9:465-79. 2009
    ..In this Review we describe the role of CLR signalling in regulating adaptive immunity and immunopathogenesis and discuss how this knowledge can be harnessed for the development of innovative vaccination approaches...
  89. ncbi In vivo-matured Langerhans cells continue to take up and process native proteins unlike in vitro-matured counterparts
    C Ruedl
    Basel Institute for Immunology, Basel, Switzerland
    J Immunol 166:7178-82. 2001
    ..Surprisingly, however, these cells, instead of shutting down, maintain the capacity to capture and process protein Ags during the couple of days they stay alive in stark contrast to in vitro-matured dendritic cells...
  90. pmc The C-type lectin surface receptor DCIR acts as a new attachment factor for HIV-1 in dendritic cells and contributes to trans- and cis-infection pathways
    Alexandra A Lambert
    Faculte de Medecine, Centre de Recherche en Infectiologie, Centre hospitalier de l Universite Laval, Universite Laval, Quebec, QC, Canada
    Blood 112:1299-307. 2008
    ..These results point to a possible role for DCIR in HIV-1 pathogenesis by supporting the productive infection of DCs and promoting virus propagation...
  91. ncbi HLA-E binds to natural killer cell receptors CD94/NKG2A, B and C
    V M Braud
    Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, UK
    Nature 391:795-9. 1998
    ....
  92. ncbi Structure and function of natural killer cell receptors: multiple molecular solutions to self, nonself discrimination
    Kannan Natarajan
    Molecular Biology Section, Laboratory of Immunology, NIAID, NIH, Bethesda, Maryland 20892 1892, USA
    Annu Rev Immunol 20:853-85. 2002
    ....
  93. ncbi Direct recognition of cytomegalovirus by activating and inhibitory NK cell receptors
    Hisashi Arase
    Department of Microbiology and Immunology and the Cancer Research Institute, University of California San Francisco, San Francisco, CA 94143, USA
    Science 296:1323-6. 2002
    ..These activating and inhibitory receptors are highly homologous, suggesting the possibility that one evolved from the other in response to selective pressure imposed by the pathogen...
  94. ncbi Regional quantification of cartilage type II collagen and aggrecan messenger RNA in joints with early experimental osteoarthritis
    John Robert Matyas
    Department of Cell Biology and Anatomy, McCaig Centre for Joint Injury and Arthritis Research, Faculty of Medicine, University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta T2N 4N1, Canada
    Arthritis Rheum 46:1536-43. 2002
    ..This study was conducted to explore the anabolic metabolism of chondrocytes early in the natural history of an experimental canine model of OA...
  95. ncbi Ligand recognition by antigen-presenting cell C-type lectin receptors
    Eamon P McGreal
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK
    Curr Opin Immunol 17:18-24. 2005
    ..New studies have also demonstrated that different ligand binding and/or sensing receptors collaborate for full and effective immune responses...
  96. ncbi Cellular encapsulation and melanization are enhanced by immulectins, pattern recognition receptors from the tobacco hornworm Manduca sexta
    Erjun Ling
    Division of Cell Biology and Biophysics, School of Biological Sciences, University of Missouri Kansas City, Kansas City, MO 64110, USA
    Dev Comp Immunol 30:289-99. 2006
    ..Our results suggest that humoral pattern recognition receptors may enhance cellular encapsulation and melanization...
  97. ncbi The C type lectins DC-SIGN and L-SIGN: receptors for viral glycoproteins
    Pierre Yves Lozach
    Laboratoire de Pathogénie Virale Moléculaire, Institut Pasteur, Paris, France
    Methods Mol Biol 379:51-68. 2007
    ..We will also describe techniques to investigate the molecular mechanisms by which DC-SIGN or L-SIGN spread viral infections...
  98. pmc Role of the mannose receptor in a murine model of Cryptococcus neoformans infection
    Jennifer M Dan
    Department of Microbiology and Immunology Training Program, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Infect Immun 76:2362-7. 2008
    ..These studies demonstrate a nonredundant role for the MR in the development of CD4(+) T-cell responses to MP and protection from C. neoformans...
  99. doi CLEC5A is critical for dengue-virus-induced lethal disease
    Szu Ting Chen
    Department and Institute of Microbiology and Immunology, National Yang Ming University, Taipei 112, Taiwan
    Nature 453:672-6. 2008
    ....
  100. pmc Dectin-2 recognition of house dust mite triggers cysteinyl leukotriene generation by dendritic cells
    Nora A Barrett
    Department of Medicine, Harvard Medical School, and Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Immunol 182:1119-28. 2009
    ....
  101. doi Novel subset of CD8{alpha}+ dendritic cells localized in the marginal zone is responsible for tolerance to cell-associated antigens
    Chun Hong Qiu
    RIKEN Research Center for Allergy and Immunology, Kanagawa, Japan
    J Immunol 182:4127-36. 2009
    ..Transient ablation of this DC subset by cytochrome c injection resulted in a failure of tolerance induction to cell-associated Ags, indicating that this DC subset is essential for tolerance induction by apoptotic cell clearance...

Research Grants67

  1. Carole R Mendelson; Fiscal Year: 2016
    ....
  2. Inhibiting Mucosal HIV-1 Transmission by Host Cell RNA Interference
    Alexandra L Howell; Fiscal Year: 2013
    ..In addition, DC can capture HIV-1 via viral binding to C type lectins including DC-SIGN (DC-specific ICAM-grabbing non-integrin)...
  3. DC-SIGN Inhibitors for the Treatment of HIV Infection
    ALLEN BERNARD REITZ; Fiscal Year: 2013
    ....
  4. Sulfotransferases in the Synthesis of L-Selectin Ligands
    Steven D Rosen; Fiscal Year: 2010
    ..Understanding this mechanism may lead to new pharmacologic approaches for dampening eosinophil responses. ..
  5. Microenvironmental changes on NK cell responses to primary HSV-1
    Andrew J Tarr; Fiscal Year: 2011
    ..Understanding the mechanisms by which these factors enhance anti-viral immunity is essential to the development of novel strategies to delay onset and progression of HSV in at risk populations. ..
  6. miRNAs and epidermal langerhans cell development and function
    Qing Sheng Mi; Fiscal Year: 2011
    ....
  7. Evaluation of the Effects of Chikungunya N-linked Glycosylation on Pathogenesis
    CHARLES EDWIN MCGEE; Fiscal Year: 2013
    ....
  8. JEFFREY NEAL WEISER; Fiscal Year: 2016
    ..Together these studies will provide mechanistic insight into the three main features of pneumococcal carriage;why it is common, why it is transient, and why it varies greatly among isolates by capsule type. ..
  9. T1D:Investigating the Gut Microbiome, Urinary Proteome and Metabolome
    Ramana Madupu; Fiscal Year: 2011
    ..We propose to study the complex interplay of environmental, immunological and genetic factors to discover molecular signatures with a potential to advance clinical diagnosis and therapy at or before the onset of T1D. ..
  10. Tobias M Hohl; Fiscal Year: 2016
    ..fumigatus. The proposed studies serve as a model for in vivo fluorescence-based approaches that dissect the bilateral cellular outcomes of host-pathogen encounters. ..
  11. Protein Carbohydrate Interactions in Cell Communication
    James C Paulson; Fiscal Year: 2010
    ....
  12. Peripheral blood dendritic cells and periodontitis
    CHRISTOPHER WILLIAM CUTLER; Fiscal Year: 2012
    ..We propose to ultimately develop immunotherapeutic strategies for the prevention of pathogen trafficking DCs in patients at high risk for developing coronary artery disease. ..
  13. Minor fimbriae of P. gingivalis and dendritic cells
    AMIR EMANUEL ZEITUNI; Fiscal Year: 2010
    ....
  14. Lectin-Carbohydrate Interactions in the Host-Parasite System
    Xiao Qiang Yu; Fiscal Year: 2010
    ....
  15. Elizabeth Scisci; Fiscal Year: 2015
    ..Understanding the nature of these reactions between DCs and PMNs to P. gingivalis may lead to the detailed insight required for more effective means of treating chronic periodontitis. ..
  16. The regulation of inflammation and phagocytosis by CD93
    SUZANNE BOHLSON; Fiscal Year: 2009
    ..These studies will contribute to our understanding of inflammation, and may lead to CD93 directed therapeutics to regulate this process. ..
  17. Astrid E Cardona; Fiscal Year: 2016
    ..Our proposed studies will provide the first detailed assessment of CLR expression and function in CNS parasite infections and present novel therapeutic strategies. ..
  18. Peisong Gao; Fiscal Year: 2016
    ..This will provide novel insights into the role of cockroach allergen-CD206 axis in the pathogenesis of allergic diseases and offer an opportunity for novel therapies. ..
  19. Robert M Prins; Fiscal Year: 2014
    ..The generated CTL will be functionally and phenotypically characterized in vitro and in vivo using mouse glioma cell targets or those enriched for brain tumor stem cells in culture. ..
  20. Characterization of the Innate Immune Response to Crystalline Silica
    Christian W Schindler; Fiscal Year: 2010
    ..Based on intriguing preliminary studies, we propose to investigate the role receptors from the innate immune system play in mediating the specific and destructive inflammatory response to crystalline silica. ..
  21. Regulation of Lymphocyte Trafficking by S1P1 and CD69
    Mehrdad Matloubian; Fiscal Year: 2012
    ..The knowledge gained from these studies will facilitate development of therapies that target white blood cell trafficking for treatment of inflammatory diseases. ..
  22. CYTOTOXIC T CELL RESPONSES TO HHV-8
    Charles R Rinaldo; Fiscal Year: 2013
    ..This study will provide important information on CD8 T cell immunity during HHV-8 infection for development of adequate treatment and prevention strategies for HHV-8 related cancers. ..
  23. Michael B Brenner; Fiscal Year: 2015
    ..Here, we will determine what activates them and how they play a critical role in control of important fungal infections. ..
  24. Nancy L Thompson; Fiscal Year: 2016
    ....
  25. Mannose Receptor in Ricin Pathogenesis
    Nicholas J Mantis; Fiscal Year: 2010
    ..This study proposes to investigate how ricin toxin enters into cells and causes disease. The results of this study are expected to yield new insights the design of an effective antidote against this deadly toxin. ..
  26. New HIV/AIDS vaccines employing inflammatory dendritic cells
    Chae Gyu Park; Fiscal Year: 2012
    ..Successful harnessing of inflammatory dendritic cells also impacts on developing vaccines against other infections and cancer. ..
  27. Mechanisms by which Human Milk Oligosaccharides Protect Against Rotavirus
    SHARON MARIE DONOVAN; Fiscal Year: 2012
    ..Reducing the morbidity and mortality from RV will decrease health care costs and improve the quality of life for infants worldwide. ..
  28. Edward A Clark; Fiscal Year: 2016
    ....
  29. Sriram Neelamegham; Fiscal Year: 2014
    ..In the long run, we anticipate that novel strategies to antagonize selectin-ligand binding interactions will be identified from this work that may aid future drug design. ..
  30. Lora V Hooper; Fiscal Year: 2016
    ..Together, these studies should lead to fundamental insights into immune control of bacterial-mucosal associations, and will provide new perspectives on symbiotic host-microbial associations. ..
  31. Identification and vaccine adjuvant responses of dendritic cells in humans
    Sarah Schlesinger; Fiscal Year: 2011
    ..We now aim to determine the role of human Mo- DCs in vivo in concert with aims 1 and 2, looking for Mo-DCs in volunteers during exposure to safe synthetic TLR4 agonists for humans. ..
  32. Variable Proteins of Diversity-generating Retroelements
    Partho Ghosh; Fiscal Year: 2010
    ..Our project is aimed at providing basic knowledge on how these variable bacterial proteins recognize diverse targets, with the expectation that this knowledge will have practical applications. ..
  33. SCOTT PALMER COMMINS; Fiscal Year: 2014
    ....
  34. FCR DEFICIENT MICE SUSCEPTIBILITY TO PATHOGENS
    JEFFREY VICTOR RAVETCH; Fiscal Year: 2012
    ....
  35. Probing Function of the C-type Lectin DC-SIGN with Glycomimetic Ligands
    Lynne Prost; Fiscal Year: 2011
    ..A better understanding of how these types of receptors function may allow us to manipulate them for the purpose of killing pathogens, making better vaccines, or targeting immune cells to clear tumors. ..
  36. James E Casanova; Fiscal Year: 2015
    ..abstract_text> ..
  37. Yoshihide Kanaoka; Fiscal Year: 2014
    ..Utilizing an engineered Dectin-2 carbohydrate-recognition domain(s) as a tool for capturing allergen-associated ligands for DC activation may be better for new therapy. ..
  38. Richard D Cummings; Fiscal Year: 2016
    ..abstract_text> ..
  39. Variable-Protein Surface Display in Treponema denticola
    Jeffery F Miller; Fiscal Year: 2012
    ..Our studies will contribute to an understanding of colonization and virulence mechanisms by this oral bacterium. ..
  40. CHRISTOPHER WILLIAM CUTLER; Fiscal Year: 2014
    ..The purpose of this application is to determine how this species is able to persist in dendritic cells and suppress their functions. ..
  41. Docking DRibbles to dendritic cells via C-type lectin receptors
    Hong Ming Hu; Fiscal Year: 2010
    ..Data generated from this innovative grant will be used to support future clinical trials. ..
  42. Eric Pearlman; Fiscal Year: 2016
    ..Results of these studies will further our understanding of the role of PMN-17 cells in fungal keratitis and identify novel targets for anti-inflammatory intervention to limit tissue damage in the cornea. ..
  43. CD1d and NKT Cell Activation and Function in Infection
    Michael B Brenner; Fiscal Year: 2010
    ..abstract_text> ..
  44. Molecular Mechanisms Regulating Axon Guidance Receptor Activity
    William G Wadsworth; Fiscal Year: 2013
    ....
  45. A T-independent pathway of B cell responses to oligomannosyl antigens of HIV-1
    Denong Wang; Fiscal Year: 2013
    ..Information obtained by this study is likely instructive to development of novel vaccination strategies against HIV-1 and other pathogens that express oligomannosyl sugar moieties. ..
  46. Regulation of Myoblast Fusion
    Grace K Pavlath; Fiscal Year: 2010
    ..Studies of the MR may lead to new strategies for manipulating myoblasts in disease, repair and aging and define novel therapeutic targets for enhancing muscle growth. ..
  47. Robert L Modlin; Fiscal Year: 2016
    ....
  48. Innate Signaling, Cysteinyl Leukotrienes, and Asthma Elicited by House Dust Mite
    NORA AMANDA BARRETT; Fiscal Year: 2013
    ..Studies to determine why this house dust mite is so immunogenic will be helpful to design new therapies for asthma prevention and treatment. ..
  49. Anergizing effect of NK cell receptor expression on HIV-specific CD8+ T cells
    Galit Alter; Fiscal Year: 2009
    ..abstract_text> ..
  50. James H Prestegard; Fiscal Year: 2016
    ..abstract_text> ..
  51. Structure/function studies of CTLD NK immunoreceptors
    Roland K Strong; Fiscal Year: 2010
    ....
  52. Immunogenetic Analysis of Human Immune Response to Allergens
    Shau Ku Huang; Fiscal Year: 2012
    ....
  53. Altered M. tuberculosis Mannosylation and the Macrophage
    Larry S Schlesinger; Fiscal Year: 2010
    ..abstract_text> ..
  54. Dendritic cells, Mucosal Immunity and C-type Lectins
    Edward Clark; Fiscal Year: 2009
    ..gingivalis as measured by alveolar bone loss and antibody responses. This work will lead to better understanding about how microflora can affect DCs. ..
  55. Role of the Fetus in the Initiation of Parturition
    CAROLE MENDELSON; Fiscal Year: 2004
    ..abstract_text> ..
  56. Novel Antioxidant Mechanisms of Surfactant Proteins
    Francis McCormack; Fiscal Year: 2006
    ..The results will provide important insights into the roles of the surfactant proteins in preventing oxidative lung disease and may be useful for the design of novel recombinant proteins and peptides of therapeutic value. ..
  57. BRAIN EXTRACELLULAR MATRIX--ROLES IN NEURAL FUNCTION AND
    Yu Yamaguchi; Fiscal Year: 2002
    ....
  58. Growth Factor Interactions with Type II Procollagen
    Audrey McAlinden; Fiscal Year: 2004
    ..The data obtained will assist with the development of strategies to examine the effect of over-expressing selected mutants in transgenic mice. ..
  59. Role of sLeX-modified O-glycans in carcinoma metastasis
    Catherine St Hill; Fiscal Year: 2009
    ..abstract_text> ..
  60. Synthetic oligosaccharides for dendritic cell targeting
    Nir Hacohen; Fiscal Year: 2006
    ..abstract_text> ..
  61. CELL SURFACE CARBOHYDRATE RECOGNITION BY C-TYPE LECTINS
    WILLIAM WEIS; Fiscal Year: 2006
    ..The structures of strongly binding peptides bound to DC-SIGN will be determined. ..
  62. Novel Immunotoxins for Depletion of Dendritic Cells
    Warren Shlomchik; Fiscal Year: 2005
    ..The goal of our work is to prevent this attack, thereby making this therapy safer and more widely applicable ..
  63. Targeting TLR/CLR to enhance immunoregulation and prevent or treat diabetes.
    Pascale Alard; Fiscal Year: 2007
    ..The results of these experiments should provide a basis for the development of novel strategies for the treatment of diabetes. ..