drosophila proteins

Summary

Summary: Proteins that originate from insect species belonging to the genus DROSOPHILA. The proteins from the most intensely studied species of Drosophila, DROSOPHILA MELANOGASTER, are the subject of much interest in the area of MORPHOGENESIS and development.

Top Publications

  1. pmc The developmental transcriptome of Drosophila melanogaster
    Brenton R Graveley
    Department of Genetics and Developmental Biology, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, Connecticut 06030 6403, USA
    Nature 471:473-9. 2011
  2. pmc FlyBase: enhancing Drosophila Gene Ontology annotations
    Susan Tweedie
    Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, UK
    Nucleic Acids Res 37:D555-9. 2009
  3. pmc Identification of functional elements and regulatory circuits by Drosophila modENCODE
    Sushmita Roy
    Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology MIT, Cambridge, MA 02139, USA
    Science 330:1787-97. 2010
  4. ncbi Role of histone H3 lysine 27 methylation in Polycomb-group silencing
    Ru Cao
    Department of Biochemistry and Biophysics, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7295, USA
    Science 298:1039-43. 2002
  5. ncbi A Toll-like receptor recognizes bacterial DNA
    H Hemmi
    Department of Host Defense, Research Institute for Microbial Diseases, Osaka University and Core Research for Evolutional Science and Technology, Japan Science and Technology Corporation, Suita
    Nature 408:740-5. 2000
  6. ncbi Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene
    A Poltorak
    Howard Hughes Medical Institute and the Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75235 9050, USA
    Science 282:2085-8. 1998
  7. pmc Systematic protein location mapping reveals five principal chromatin types in Drosophila cells
    Guillaume J Filion
    Division of Gene Regulation, Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    Cell 143:212-24. 2010
  8. pmc A GAL4-driver line resource for Drosophila neurobiology
    Arnim Jenett
    Janelia Farm Research Campus, Howard Hughes Medical Institute, 19700 Helix Drive, Ashburn, VA 20147, USA
    Cell Rep 2:991-1001. 2012
  9. ncbi bantam encodes a developmentally regulated microRNA that controls cell proliferation and regulates the proapoptotic gene hid in Drosophila
    Julius Brennecke
    European Molecular Biology Laboratory, Meyerhofstr 1, 69117 Heidelberg, Germany
    Cell 113:25-36. 2003
  10. pmc Comprehensive analysis of the chromatin landscape in Drosophila melanogaster
    Peter V Kharchenko
    Center for Biomedical Informatics, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 471:480-5. 2011

Detail Information

Publications263 found, 100 shown here

  1. pmc The developmental transcriptome of Drosophila melanogaster
    Brenton R Graveley
    Department of Genetics and Developmental Biology, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, Connecticut 06030 6403, USA
    Nature 471:473-9. 2011
    ..These data substantially expand the number of known transcribed elements in the Drosophila genome and provide a high-resolution view of transcriptome dynamics throughout development...
  2. pmc FlyBase: enhancing Drosophila Gene Ontology annotations
    Susan Tweedie
    Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, UK
    Nucleic Acids Res 37:D555-9. 2009
    ..Many of these changes stem from our participation in the GO Reference Genome Annotation Project--a multi-database collaboration producing comprehensive GO annotation sets for 12 diverse species...
  3. pmc Identification of functional elements and regulatory circuits by Drosophila modENCODE
    Sushmita Roy
    Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology MIT, Cambridge, MA 02139, USA
    Science 330:1787-97. 2010
    ..Our results provide a foundation for directed experimental and computational studies in Drosophila and related species and also a model for systematic data integration toward comprehensive genomic and functional annotation...
  4. ncbi Role of histone H3 lysine 27 methylation in Polycomb-group silencing
    Ru Cao
    Department of Biochemistry and Biophysics, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7295, USA
    Science 298:1039-43. 2002
    ..Methylation on H3-K27 facilitates binding of Polycomb (PC), a component of the PRC1 complex, to histone H3 amino-terminal tail. Thus, these studies establish a link between histone methylation and PcG-mediated gene silencing...
  5. ncbi A Toll-like receptor recognizes bacterial DNA
    H Hemmi
    Department of Host Defense, Research Institute for Microbial Diseases, Osaka University and Core Research for Evolutional Science and Technology, Japan Science and Technology Corporation, Suita
    Nature 408:740-5. 2000
    ..The in vivo CpG-DNA-mediated T-helper type-1 response was also abolished in TLR9-/- mice. Thus, vertebrate immune systems appear to have evolved a specific Toll-like receptor that distinguishes bacterial DNA from self-DNA...
  6. ncbi Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene
    A Poltorak
    Howard Hughes Medical Institute and the Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75235 9050, USA
    Science 282:2085-8. 1998
    ..Destructive mutations of Tlr4 predispose to the development of Gram-negative sepsis, leaving most aspects of immune function intact...
  7. pmc Systematic protein location mapping reveals five principal chromatin types in Drosophila cells
    Guillaume J Filion
    Division of Gene Regulation, Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    Cell 143:212-24. 2010
    ..Finally, we provide evidence that the different chromatin types help to target DNA-binding factors to specific genomic regions. These results provide a global view of chromatin diversity and domain organization in a metazoan cell...
  8. pmc A GAL4-driver line resource for Drosophila neurobiology
    Arnim Jenett
    Janelia Farm Research Campus, Howard Hughes Medical Institute, 19700 Helix Drive, Ashburn, VA 20147, USA
    Cell Rep 2:991-1001. 2012
    ..The set of DNA fragments, each driving a documented expression pattern, will facilitate the generation of additional constructs for manipulating neuronal function...
  9. ncbi bantam encodes a developmentally regulated microRNA that controls cell proliferation and regulates the proapoptotic gene hid in Drosophila
    Julius Brennecke
    European Molecular Biology Laboratory, Meyerhofstr 1, 69117 Heidelberg, Germany
    Cell 113:25-36. 2003
    ..bantam microRNA simultaneously stimulates cell proliferation and prevents apoptosis. We identify the pro-apoptotic gene hid as a target for regulation by bantam miRNA, providing an explanation for bantam's anti-apoptotic activity...
  10. pmc Comprehensive analysis of the chromatin landscape in Drosophila melanogaster
    Peter V Kharchenko
    Center for Biomedical Informatics, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 471:480-5. 2011
    ..This systematic profiling and integrative analysis of chromatin signatures provides insights into how genomic elements are regulated, and will serve as a resource for future experimental investigations of genome structure and function...
  11. ncbi Discrete small RNA-generating loci as master regulators of transposon activity in Drosophila
    Julius Brennecke
    Cold Spring Harbor Laboratory, Watson School of Biological Sciences and Howard Hughes Medical Institute, Cold Spring Harbor, NY 11724, USA
    Cell 128:1089-103. 2007
    ..Thus, sense piRNAs, formed following cleavage of transposon mRNAs may enhance production of antisense piRNAs, complementary to active elements, by directing cleavage of transcripts from master control loci...
  12. pmc The hippo signaling pathway in development and cancer
    Duojia Pan
    Department of Molecular Biology and Genetics, Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Dev Cell 19:491-505. 2010
    ..These studies suggest that the core Hippo kinase cascade integrates multiple upstream inputs, enabling dynamic regulation of tissue homeostasis in animal development and physiology...
  13. ncbi The dorsoventral regulatory gene cassette spätzle/Toll/cactus controls the potent antifungal response in Drosophila adults
    B Lemaitre
    Institut de Biologie Moléculaire at Cellulaire, UPR 9022 du Centre National de la Recherche Scientifique, Strasbourg, France
    Cell 86:973-83. 1996
    ..Antibacterial genes are induced either by a distinct pathway involving the immune deficiency gene (imd) or by combined activation of both imd and dorsoventral pathways...
  14. ncbi Toll-like receptors: critical proteins linking innate and acquired immunity
    S Akira
    Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Osaka 565 0871, Japan
    Nat Immunol 2:675-80. 2001
    ..However, evidence is accumulating that the signaling pathways associated with each TLR are not identical and may, therefore, result in different biological responses...
  15. ncbi Spatiotemporal rescue of memory dysfunction in Drosophila
    Sean E McGuire
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Science 302:1765-8. 2003
    ..The TARGET system offers general utility in simultaneously addressing issues of when and where gene products are required...
  16. ncbi A human homologue of the Drosophila Toll protein signals activation of adaptive immunity
    R Medzhitov
    Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520 8011, USA
    Nature 388:394-7. 1997
    ..1, which is required for the activation of naive T cells...
  17. pmc The Hippo pathway in organ size control, tissue regeneration and stem cell self-renewal
    Bin Zhao
    Life Sciences Institute, Zhejiang University, Hangzhou, Zhejiang 310058, China
    Nat Cell Biol 13:877-83. 2011
    ..In this review we summarize current understanding of the composition and regulation of the Hippo pathway, and discuss how cell polarity and cell adhesion proteins inform the role of this pathway in organ size control and regeneration...
  18. pmc Elucidation of a universal size-control mechanism in Drosophila and mammals
    Jixin Dong
    Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Cell 130:1120-33. 2007
    ..These results uncover a universal size-control mechanism in metazoan...
  19. ncbi The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila Homolog of YAP
    Jianbin Huang
    Department of Physiology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA
    Cell 122:421-34. 2005
    ..Thus, Yki is a critical target of the Wts/Lats protein kinase and a potential oncogene...
  20. pmc Construction of transgenic Drosophila by using the site-specific integrase from phage phiC31
    Amy C Groth
    Department of Genetics, Stanford University School of Medicine, Stanford, California 94305, USA
    Genetics 166:1775-82. 2004
    ..These experiments demonstrate the potential for precise genetic engineering of the Drosophila genome with the phiC31 integrase system and will likely benefit research in Drosophila and other insects...
  21. pmc Atypical membrane topology and heteromeric function of Drosophila odorant receptors in vivo
    Richard Benton
    Laboratory of Neurogenetics and Behavior, The Rockefeller University, New York, New York, USA
    PLoS Biol 4:e20. 2006
    ....
  22. pmc Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control
    Bin Zhao
    Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109, USA
    Genes Dev 21:2747-61. 2007
    ..Our observations demonstrate that YAP plays a key role in the Hippo pathway to control cell proliferation in response to cell contact...
  23. ncbi Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin
    Ira E Clark
    Nature 441:1162-6. 2006
    ..The role of the pink1-parkin pathway in regulating mitochondrial function underscores the importance of mitochondrial dysfunction as a central mechanism of Parkinson's disease pathogenesis...
  24. ncbi Drosophila odorant receptors are both ligand-gated and cyclic-nucleotide-activated cation channels
    Dieter Wicher
    Department of Evolutionary Neuroethology, Max Planck Institute for Chemical Ecology, Hans Knöll St 8, D 07745 Jena, Germany
    Nature 452:1007-11. 2008
    ..Thereby, they provide rapid and transient as well as sensitive and prolonged odorant signalling...
  25. pmc Cofactor binding evokes latent differences in DNA binding specificity between Hox proteins
    Matthew Slattery
    Department of Biochemistry and Molecular Biophysics, Columbia University, 701 West 168 th Street, HHSC 1104, New York, NY 10032, USA
    Cell 147:1270-82. 2011
    ..Together, these data suggest that emergent DNA recognition properties revealed by interactions with cofactors contribute to transcription factor specificities in vivo...
  26. ncbi Hsp90 as a capacitor for morphological evolution
    S L Rutherford
    Howard Hughes Medical Institute, University of Chicago, Illinois 60637, USA
    Nature 396:336-42. 1998
    ..This provides a plausible mechanism for promoting evolutionary change in otherwise entrenched developmental processes...
  27. pmc A protein complex network of Drosophila melanogaster
    K G Guruharsha
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Cell 147:690-703. 2011
    ..analysis, we examined protein associations involving nearly 5,000 individual, FLAG-HA epitope-tagged Drosophila proteins. Stringent analysis of these data, based on a statistical framework designed to define individual protein-..
  28. pmc miRNA repression involves GW182-mediated recruitment of CCR4-NOT through conserved W-containing motifs
    Marina Chekulaeva
    Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland
    Nat Struct Mol Biol 18:1218-26. 2011
    ....
  29. ncbi HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the UPS
    Udai Bhan Pandey
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Nature 447:859-63. 2007
    ..Morover, these findings suggest that it may be possible to intervene in neurodegeneration by augmenting HDAC6 to enhance autophagy...
  30. ncbi Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components
    O Takeuchi
    Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Japan
    Immunity 11:443-51. 1999
    ..These results demonstrate that TLR2 and TLR4 recognize different bacterial cell wall components in vivo and TLR2 plays a major role in Gram-positive bacterial recognition...
  31. ncbi Role of histone H2A ubiquitination in Polycomb silencing
    Hengbin Wang
    Department of Biochemistry and Biophysics, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7295, USA
    Nature 431:873-8. 2004
    ..Thus, our studies identify the H2A ubiquitin ligase, and link H2A ubiquitination to Polycomb silencing...
  32. ncbi Ablation of insulin-producing neurons in flies: growth and diabetic phenotypes
    Eric J Rulifson
    Department of Developmental Biology, Beckman Center B300, Stanford University, Stanford, CA 94305 5329, USA
    Science 296:1118-20. 2002
    ..Interestingly, the phenotype of flies lacking IPCs includes certain features of diabetes mellitus...
  33. pmc Drosophila parkin requires PINK1 for mitochondrial translocation and ubiquitinates mitofusin
    Elena Ziviani
    Department of Biomedical Sciences, Medical Research Council Centre for Developmental and Biomedical Genetics, University of Sheffield, Sheffield S10 2TN, United Kingdom
    Proc Natl Acad Sci U S A 107:5018-23. 2010
    ..We hypothesize that Mfn ubiquitination may provide a mechanism by which terminally damaged mitochondria are labeled and sequestered for degradation by autophagy...
  34. ncbi Genome regulation by polycomb and trithorax proteins
    Bernd Schuettengruber
    Institute of Human Genetics, CNRS, 141, rue de la Cardonille, 34396 Montpellier Cedex 5, France
    Cell 128:735-45. 2007
    ..Recent work suggests that PcG proteins regulate the nuclear organization of their target genes and that PcG-mediated gene silencing involves noncoding RNAs and the RNAi machinery...
  35. ncbi Or83b encodes a broadly expressed odorant receptor essential for Drosophila olfaction
    Mattias C Larsson
    Laboratory of Neurogenetics and Behavior, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Neuron 43:703-14. 2004
    ..Consistent with this cellular defect, the Or83b mutation disrupts behavioral and electrophysiological responses to many odorants. Or83b therefore encodes an atypical odorant receptor that plays an essential general role in olfaction...
  36. pmc Molecular evolution and functional characterization of Drosophila insulin-like peptides
    Sebastian Gronke
    Institute of Healthy Ageing, Department of Genetics, Evolution, and Environment, University College London, London, United Kingdom
    PLoS Genet 6:e1000857. 2010
    ..Evolutionary conservation has thus been accompanied by synergy, redundancy, and functional differentiation between DILPs, and these features may themselves be of evolutionary advantage...
  37. pmc TRANSFAC and its module TRANSCompel: transcriptional gene regulation in eukaryotes
    V Matys
    BIOBASE GmbH, Halchtersche Strasse 33, D 38304 Wolfenbuttel, Germany
    Nucleic Acids Res 34:D108-10. 2006
    ..The here described public releases, TRANSFAC 7.0 and TRANSCompel 7.0, are accessible under http://www.gene-regulation.com/pub/databases.html...
  38. pmc An internal thermal sensor controlling temperature preference in Drosophila
    Fumika N Hamada
    National Center for Behavioral Genomics, Volen Center for Complex Systems, Biology Department, Brandeis University MS 008, 415 South Street, Waltham, Massachusetts 02454, USA
    Nature 454:217-20. 2008
    ..This provides a potentially general strategy for robustly selecting a narrow temperature range optimal for survival...
  39. ncbi Drosophila intestinal response to bacterial infection: activation of host defense and stem cell proliferation
    Nicolas Buchon
    Global Health Institute, Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland
    Cell Host Microbe 5:200-11. 2009
    ..The Drosophila gut provides a powerful model to study the integration of stress and immunity with pathways associated with stem cell control, and this study should prove to be a useful resource for such further studies...
  40. pmc Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein
    Andrei Kuzmichev
    Howard Hughes Medical Institute, Division of Nucleic Acids Enzymology, Department of Biochemistry, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    Genes Dev 16:2893-905. 2002
    ..The presence of Su(z)12, a strong suppressor of position effect variegation, in PRC2 suggests that PRC2 may play a widespread role in heterochromatin-mediated silencing...
  41. pmc Recruitment of human muscleblind proteins to (CUG)(n) expansions associated with myotonic dystrophy
    J W Miller
    Department of Molecular Genetics and Microbiology, Centers for Gene Therapy and Mammalian Genetics, University of Florida College of Medicine, Gainesville, FL 32610, USA
    EMBO J 19:4439-48. 2000
    ..We propose that DM1 disease is caused by aberrant recruitment of the EXP proteins to the DMPK transcript (CUG)(n) expansion...
  42. ncbi Histone methyltransferase activity of a Drosophila Polycomb group repressor complex
    Jurg Muller
    EMBL, Gene Expression Programme, Meyerhofstr 1, 69117 Heidelberg, Germany
    Cell 111:197-208. 2002
    ..These results identify E(Z) as a PcG protein with enzymatic activity and implicate histone methylation in PcG-mediated silencing...
  43. ncbi Histone H4-K16 acetylation controls chromatin structure and protein interactions
    Michael Shogren-Knaak
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Science 311:844-7. 2006
    ....
  44. pmc Exploiting position effects and the gypsy retrovirus insulator to engineer precisely expressed transgenes
    Michele Markstein
    Department of Genetics and Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Genet 40:476-83. 2008
    ..The generality of our approach makes it adaptable to other model systems to identify and modify loci for optimal transgene expression...
  45. ncbi Notch signaling: simplicity in design, versatility in function
    Emma R Andersson
    Department of Cell and Molecular Biology, Karolinska Institute, SE 171 77 Stockholm, Sweden
    Development 138:3593-612. 2011
    ....
  46. ncbi Correlates of sleep and waking in Drosophila melanogaster
    P J Shaw
    The Neurosciences Institute, 10640 John Jay Hopkins Drive, San Diego, CA 92121, USA
    Science 287:1834-7. 2000
    ..These results implicate the catabolism of monoamines in the regulation of sleep and waking in the fly and suggest that Drosophila may serve as a model system for the genetic dissection of sleep...
  47. pmc Cytokine/Jak/Stat signaling mediates regeneration and homeostasis in the Drosophila midgut
    Huaqi Jiang
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA
    Cell 137:1343-55. 2009
    ..Hence, cytokine-mediated feedback enables stem cells to replace spent progeny as they are lost, thereby establishing gut homeostasis...
  48. pmc Hippo signaling: growth control and beyond
    Georg Halder
    Department of Biochemistry and Molecular Biology, MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Development 138:9-22. 2011
    ....
  49. ncbi hippo encodes a Ste-20 family protein kinase that restricts cell proliferation and promotes apoptosis in conjunction with salvador and warts
    Shian Wu
    Department of Physiology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Cell 114:445-56. 2003
    ..A human homolog of hpo completely rescues the overgrowth phenotype of Drosophila hpo mutants, suggesting that hpo might play a conserved role for growth control in mammals...
  50. ncbi Evolution of genes and genomes on the Drosophila phylogeny
    Andrew G Clark
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853, USA
    Nature 450:203-18. 2007
    ..These may prove to underlie differences in the ecology and behaviour of these diverse species...
  51. pmc X chromosome dosage compensation via enhanced transcriptional elongation in Drosophila
    Erica Larschan
    Division of Genetics, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Nature 471:115-8. 2011
    ..Improving transcriptional output downstream of typical gene-specific controls may explain how dosage compensation can be imposed on the diverse set of genes along an entire chromosome...
  52. ncbi Drosophila enhancer of Zeste/ESC complexes have a histone H3 methyltransferase activity that marks chromosomal Polycomb sites
    Birgit Czermin
    Adolf Butenandt Institut, University of Munich, Schillerstrasse 44, 80336 Munich, Germany
    Cell 111:185-96. 2002
    ..Histone H3 methylated in vitro by the E(Z)/ESC complex binds specifically to Polycomb protein...
  53. pmc The Toll and Imd pathways are the major regulators of the immune response in Drosophila
    Ennio De Gregorio
    Centre de Genetique Moleculaire, CNRS, F 91198 Gif sur Yvette, France
    EMBO J 21:2568-79. 2002
    ..Interestingly, we observed that some Drosophila immune-responsive genes are located in gene clusters, which often are transcriptionally co-regulated...
  54. pmc MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4
    R Shimazu
    Department of Immunology, Saga Medical School, Saga, Japan
    J Exp Med 189:1777-82. 1999
    ..MD-2 is thus a link between TLR4 and LPS signaling. Identification of this new receptor complex has potential implications for understanding host defense, as well as pathophysiologic, mechanisms...
  55. pmc A comprehensive map of insulator elements for the Drosophila genome
    Nicolas Negre
    Institute for Genomics and Systems Biology, Department of Human Genetics, and Department of Ecology and Evolution, University of Chicago, Chicago, Illinois, USA
    PLoS Genet 6:e1000814. 2010
    ..Together, these results provide a map demarcating the boundaries of gene regulatory units and a framework for understanding insulator function during the development and evolution of Drosophila...
  56. pmc Contact chemoreceptors mediate male-male repulsion and male-female attraction during Drosophila courtship
    Robert Thistle
    Department of Molecular and Cell Biology and Helen Wills Neuroscience Institute, 16 Barker Hall, University of California, Berkeley, Berkeley, CA 94720, USA
    Cell 149:1140-51. 2012
    ..These studies identify a large population of pheromone-sensing neurons and demonstrate the essential role of contact chemosensation in the early courtship steps of mate selection and courtship initiation...
  57. pmc Chromatin remodelling during development
    Lena Ho
    Stanford University Medical School, Room B211, Beckman Center, 279 Campus Drive, Stanford, California 94305, USA
    Nature 463:474-84. 2010
    ..Particularly intriguing are the findings that specialized assemblies of ATP-dependent remodellers are essential for establishing and maintaining pluripotent and multipotent states in cells...
  58. ncbi GW182 proteins directly recruit cytoplasmic deadenylase complexes to miRNA targets
    Joerg E Braun
    Department of Biochemistry, Max Planck Institute for Developmental Biology, Spemannstrasse 35, D 72076 Tubingen, Germany
    Mol Cell 44:120-33. 2011
    ....
  59. ncbi Human Argonaute2 mediates RNA cleavage targeted by miRNAs and siRNAs
    Gunter Meister
    Laboratory of RNA Molecular Biology, The Rockefeller University, 1230 York Avenue, Box 186, New York, NY 10021, USA
    Mol Cell 15:185-97. 2004
    ..The specific role of Ago2 in guiding target RNA cleavage was confirmed independently by siRNA-based depletion of individual Ago members in combination with a sensitive positive-readout reporter assay...
  60. ncbi Polycomb-dependent regulatory contacts between distant Hox loci in Drosophila
    Frédéric Bantignies
    Institut de Genetique Humaine, CNRS UPR 1142, Montpellier, France
    Cell 144:214-26. 2011
    ..Thus, the three-dimensional organization of Polycomb target genes in the cell nucleus stabilizes the maintenance of epigenetic gene silencing...
  61. ncbi Remote control of insulin secretion by fat cells in Drosophila
    Charles Geminard
    Institute for Developmental Biology and Cancer, CNRS University of Nice Sophia Antipolis, Parc Valrose, 06108 Nice, France
    Cell Metab 10:199-207. 2009
    ..Thus, the availability of nutrients is remotely sensed in fat body cells and conveyed to the brain IPCs by a humoral signal controlling ILP release...
  62. ncbi Global analysis of mRNA localization reveals a prominent role in organizing cellular architecture and function
    Eric Lecuyer
    Banting and Best Department of Medical Research, University of Toronto, Toronto, Canada
    Cell 131:174-87. 2007
    ..A searchable web resource documenting mRNA expression and localization dynamics has been established and will serve as an invaluable tool for dissecting localization mechanisms and for predicting gene functions and interactions...
  63. ncbi Reactive oxygen species prime Drosophila haematopoietic progenitors for differentiation
    Edward Owusu-Ansah
    Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, California 90095, USA
    Nature 461:537-41. 2009
    ..Our results lead to a model that could be extended to reveal a probable signalling role for ROS in the differentiation of CMPs in mammalian haematopoietic development and oxidative stress response...
  64. pmc Genome-wide analysis of self-renewal in Drosophila neural stem cells by transgenic RNAi
    Ralph A Neumüller
    Institute of Molecular Biotechnology of the Austrian Academy of Sciences IMBA, Dr Bohr Gasse 3, 1030 Vienna, Austria
    Cell Stem Cell 8:580-93. 2011
    ..As our data are strongly enriched for genes highly expressed in murine neural stem cells, they are likely to provide valuable insights into mammalian stem cell biology as well...
  65. pmc Analysis of homeodomain specificities allows the family-wide prediction of preferred recognition sites
    Marcus B Noyes
    Program in Gene Function and Expression, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Cell 133:1277-89. 2008
    ..This resource also allows prediction of homeodomain specificities from other organisms, which is demonstrated by the prediction and analysis of human homeodomain specificities...
  66. pmc An endogenous small interfering RNA pathway in Drosophila
    Benjamin Czech
    Watson School of Biological Sciences, Howard Hughes Medical Institute, Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA
    Nature 453:798-802. 2008
    ..These observations expand the repertoire of small RNAs in Drosophila, adding a class that blurs distinctions based on known biogenesis mechanisms and functional roles...
  67. ncbi Evidence that stem cells reside in the adult Drosophila midgut epithelium
    Craig A Micchelli
    Department of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA
    Nature 439:475-9. 2006
    ..The ability to identify, manipulate and genetically trace cell lineages in the midgut should lead to the discovery of additional genes that regulate stem and progenitor cell biology in the gastrointestinal tract...
  68. ncbi Rest in Drosophila is a sleep-like state
    J C Hendricks
    Center for Sleep and Respiratory Neurobiology, School of Medicine, University of Pennsylvania, Philadelphia 19104, USA
    Neuron 25:129-38. 2000
    ..Finally, normal homeostatic regulation depends on the timeless but not the period central clock gene. Understanding the molecular features of Drosophila rest should shed new light on the mechanisms and function of sleep...
  69. ncbi Gene expression divergence recapitulates the developmental hourglass model
    Alex T Kalinka
    Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstr 108, 01307 Dresden, Germany
    Nature 468:811-4. 2010
    ..These results indicate that natural selection acts to conserve patterns of gene expression during mid-embryogenesis, and provide a genome-wide insight into the molecular basis of the hourglass pattern of developmental evolution...
  70. ncbi The adult Drosophila posterior midgut is maintained by pluripotent stem cells
    Benjamin Ohlstein
    Howard Hughes Medical Institute Research Laboratories, Department of Embryology, Carnegie Institution of Washington, 3520 San Martin Drive, Baltimore, Maryland 21218, USA
    Nature 439:470-4. 2006
    ..The identification of Drosophila intestinal stem cells with striking similarities to their vertebrate counterparts will facilitate the genetic analysis of normal and abnormal intestinal function...
  71. pmc The role of Drosophila Piezo in mechanical nociception
    Sung Eun Kim
    Department of Cell Biology, Dorris Neuroscience Center, The Scripps Research Institute, La Jolla, California 92037, USA
    Nature 483:209-12. 2012
    ..These data demonstrate the physiological relevance of the Piezo family in mechanotransduction in vivo, supporting a role of Piezo proteins in mechanosensory nociception...
  72. pmc Phenotypic robustness conferred by apparently redundant transcriptional enhancers
    Nicolas Frankel
    Howard Hughes Medical Institute and Department of Ecology and Evolutionary Biology, Princeton University, Princeton, New Jersey 08544, USA
    Nature 466:490-3. 2010
    ..These results support the hypothesis that secondary enhancers contribute to phenotypic robustness in the face of environmental and genetic variability...
  73. ncbi Antimicrobial peptides in insects; structure and function
    P Bulet
    Institut de Biologie Moleculaire et Cellulaire, Unité Propre de Recherche du CNRS 9022, Strasbourg, France
    Dev Comp Immunol 23:329-44. 1999
    ..This review presents the main results obtained during the last four years in the field of antimicrobial peptides from insects with a special focus on the proline-rich and cysteine-rich peptides...
  74. pmc Genome-wide kinetics of nucleosome turnover determined by metabolic labeling of histones
    Roger B Deal
    Basic Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Science 328:1161-4. 2010
    ....
  75. pmc Sorting of Drosophila small silencing RNAs partitions microRNA* strands into the RNA interference pathway
    Megha Ghildiyal
    Howard Hughes Medical Institute, Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    RNA 16:43-56. 2010
    ..Our findings provide the first genome-wide test for the idea that Drosophila small RNAs are sorted between Ago1 and Ago2 according to their duplex structure and the identity of their first nucleotide...
  76. ncbi Epigenetic regulation of cellular memory by the Polycomb and Trithorax group proteins
    Leonie Ringrose
    ZMBH, University of Heidelberg, 69120 Heidelberg, Germany
    Annu Rev Genet 38:413-43. 2004
    ..Here we review current ideas on the protein and DNA components of this transcriptional memory system and how they interact dynamically with each other to orchestrate cellular memory for several hundred genes...
  77. ncbi Flies without centrioles
    Renata Basto
    The Gurdon Institute, Tennis Court Road, Cambridge CB2 1QN, UK
    Cell 125:1375-86. 2006
    ..Thus, centrioles are essential for the formation of centrosomes, cilia, and flagella, but, remarkably, they are not essential for most aspects of Drosophila development...
  78. ncbi The shaping of male courtship posture by lateralized gustatory inputs to male-specific interneurons
    Masayuki Koganezawa
    Division of Neurogenetics, Tohoku University Graduate School of Life Sciences, Sendai 980 8578, Japan
    Curr Biol 20:1-8. 2010
    ..These observations prompted the postulation that the proper wing display by courting males of D. melanogaster does not require sensory inputs...
  79. ncbi Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
    D D Sarbassov
    Whitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Technology, Nine Cambridge Center, Cambridge, MA 02142, USA
    Science 307:1098-101. 2005
    ..Rictor-mTOR may serve as a drug target in tumors that have lost the expression of PTEN, a tumor suppressor that opposes Akt/PKB activation...
  80. ncbi Activation of pheromone-sensitive neurons is mediated by conformational activation of pheromone-binding protein
    John D Laughlin
    Department of Pharmacology, University of Colorado at Denver and Health Sciences Center, 12801 East 17th Avenue, M S 8303, P O Box 6511, Aurora, CO 80045, USA
    Cell 133:1255-65. 2008
    ..Therefore, the pheromone-binding protein is an inactive, extracellular ligand converted by pheromone molecules into an activator of pheromone-sensitive neurons and reveals a distinct paradigm for detection of odorants...
  81. pmc Opposing effects of polyglutamine expansion on native protein complexes contribute to SCA1
    Janghoo Lim
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Nature 452:713-8. 2008
    ..This model provides mechanistic insight into the molecular pathogenesis of SCA1 as well as other polyglutamine diseases...
  82. pmc Alternative epigenetic chromatin states of polycomb target genes
    Yuri B Schwartz
    Department of Molecular Biology and Biochemistry, Rutgers University, Nelson Laboratories, Piscataway, New Jersey, United States of America
    PLoS Genet 6:e1000805. 2010
    ..These results have important implications for Polycomb gene regulation, the "bivalent" chromatin state of embryonic stem cells, and gene expression in development...
  83. ncbi A single p450 allele associated with insecticide resistance in Drosophila
    P J Daborn
    Department of Biology and Biochemistry, University of Bath, Bath BA2 7AY, UK
    Science 297:2253-6. 2002
    ..This allele is characterized by the insertion of an Accord transposable element into the 5' end of the Cyp6g1 gene...
  84. pmc DroID 2011: a comprehensive, integrated resource for protein, transcription factor, RNA and gene interactions for Drosophila
    Thilakam Murali
    Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, Michigan, USA
    Nucleic Acids Res 39:D736-43. 2011
    ..Improvements have been made to the web and graphical interfaces to help biologists gain a comprehensive view of the interaction networks relevant to the genes and systems that they study...
  85. ncbi Two chemosensory receptors together mediate carbon dioxide detection in Drosophila
    Walton D Jones
    Laboratory of Neurogenetics and Behavior, The Rockefeller University, 1230 York Avenue, New York, New York 10021, USA
    Nature 445:86-90. 2007
    ..This in turn could bolster the worldwide fight against malaria and other insect-borne diseases...
  86. pmc The role of anorexia in resistance and tolerance to infections in Drosophila
    Janelle S Ayres
    Department of Microbiology and Immunology, Stanford University, Stanford, California, USA
    PLoS Biol 7:e1000150. 2009
    ..This suggests that attempts to extend lifespan through diet restriction or the manipulation of pathways mimicking this process will have complicated effects on a host's ability to fight infections...
  87. pmc RNAi-independent role for Argonaute2 in CTCF/CP190 chromatin insulator function
    Nellie Moshkovich
    Laboratory of Cellular and Developmental Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Genes Dev 25:1686-701. 2011
    ..We propose that RNAi-independent recruitment of AGO2 to chromatin by insulator proteins promotes the definition of transcriptional domains throughout the genome...
  88. ncbi Signalling downstream of activated mammalian Notch
    S Jarriault
    Unité de Biologie Moléculaire de l Expression Génique, URA 1149 CNRS, Institut Pasteur, Paris, France
    Nature 377:355-8. 1995
    ..Here we show that activated forms of mNotch associate with the human analogue of Su(H), KBF2/RBP-J kappa (refs 8,9) and act as transcriptional activators through the KBF2-binding sites of the HES-1 promoter...
  89. pmc Fat cells reactivate quiescent neuroblasts via TOR and glial insulin relays in Drosophila
    Rita Sousa-Nunes
    Division of Developmental Neurobiology, Medical Research Council National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Nature 471:508-12. 2011
    ..This mechanism indicates that dietary nutrients and remote organs, as well as local niches, are key regulators of transitions in stem-cell behaviour...
  90. ncbi The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5
    F Hayashi
    Department of Immunology, University of Washington, Seattle 98195, USA
    Nature 410:1099-103. 2001
    ..Our data suggest that TLR5, a member of the evolutionarily conserved Toll-like receptor family, has evolved to permit mammals specifically to detect flagellated bacterial pathogens...
  91. pmc Transforming properties of YAP, a candidate oncogene on the chromosome 11q22 amplicon
    Michael Overholtzer
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 103:12405-10. 2006
    ....
  92. pmc Paucity of genes on the Drosophila X chromosome showing male-biased expression
    Michael Parisi
    Laboratory of Cellular and Developmental Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892 8028, USA
    Science 299:697-700. 2003
    ..These data indicate that the X chromosome is a disfavored location for genes selectively expressed in males...
  93. pmc High-fat-diet-induced obesity and heart dysfunction are regulated by the TOR pathway in Drosophila
    Ryan T Birse
    NASCR Center, Sanford Burnham Medical Research Institute, La Jolla, CA 92037, USA
    Cell Metab 12:533-44. 2010
    ..We conclude that deregulation of insulin-TOR signaling due to a HFD is responsible for mediating the detrimental effects on metabolism and heart function...
  94. pmc Principles of planar polarity in animal development
    Lisa V Goodrich
    Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA
    Development 138:1877-92. 2011
    ..Here, we review the molecular mechanisms and cellular consequences of planar polarisation in diverse contexts, seeking to identify the common principles across the animal kingdom...
  95. pmc Polycomb preferentially targets stalled promoters of coding and noncoding transcripts
    Daniel Enderle
    Department of Biosystems Science and Engineering, ETH Zurich, CH 4058 Basel, Switzerland
    Genome Res 21:216-26. 2011
    ..Interestingly, this set includes previously unknown promoters for primary transcripts of microRNA genes, thereby expanding the scope of Polycomb control to noncoding RNAs essential for development, apoptosis, and growth...
  96. pmc A novel class of evolutionarily conserved genes defined by piwi are essential for stem cell self-renewal
    D N Cox
    Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710 USA
    Genes Dev 12:3715-27. 1998
    ..Decreasing C. elegans piwi expression reduces the proliferation of GSC-equivalent cells. Thus, piwi represents a novel class of genes required for GSC division in diverse organisms...
  97. pmc Endogenous siRNAs derived from transposons and mRNAs in Drosophila somatic cells
    Megha Ghildiyal
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Science 320:1077-81. 2008
    ..We propose that endo-siRNAs generated by the fly RNAi pathway silence selfish genetic elements in the soma, much as Piwi-interacting RNAs do in the germ line...
  98. pmc Hox specificity unique roles for cofactors and collaborators
    Richard S Mann
    Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, USA
    Curr Top Dev Biol 88:63-101. 2009
    ....
  99. ncbi Drosophila innate immunity: an evolutionary perspective
    Jules A Hoffmann
    CNRS, Institute of Molecular and Cellular Biology, 15 rue Descartes, 67000 Strasbourg, France
    Nat Immunol 3:121-6. 2002
    ..We discuss here evolutionary perspectives on our present understanding of the antimicrobial defenses of Drosophila...
  100. ncbi Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3
    L Alexopoulou
    Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut, 06520, USA
    Nature 413:732-8. 2001
    ..Moreover, poly(I:C) can induce activation of NF-kappaB and mitogen-activated protein (MAP) kinases independently of MyD88, and cause dendritic cells to mature...
  101. pmc Functional genomic screen reveals genes involved in lipid-droplet formation and utilization
    Yi Guo
    Department of Biochemistry and Biophysics, University of California, San Francisco, California 94158, USA
    Nature 453:657-61. 2008
    ..These phenotypes are conserved in mammalian cells, suggesting that insights from these studies are likely to be central to our understanding of human diseases involving excessive lipid storage...

Research Grants65

  1. Cycling of Circadian Rhythm Proteins
    Amita Sehgal; Fiscal Year: 2013
    ..we have recently discovered/generated to dissect the post-translational regulation of the major cycling Drosophila proteins, period (PER) and timeless (TIM)...
  2. Molecular genetic analysis of ion regulation by glia at the blood-nerve barrier
    HAIG S KESHISHIAN; Fiscal Year: 2012
    ..We have found extensive molecular and functional homologies between the Drosophila proteins and their human counterparts, SPAK and NKCC1...
  3. A Cis Regulatory map of the Drosophila Genome
    Kevin P White; Fiscal Year: 2011
    ..In many cases, human proteins function in Drosophila just as well as Drosophila proteins. In addition to the shared biology, the fly also offers powerful experimental tools not yet available for ..
  4. Large-Scale High-Confidence Binary Protein Interaction Network for Drosophila
    Norbert Perrimon; Fiscal Year: 2013
    ..multi-cellular eukaryotic genome, there remains much to be learned about the functions and interactivity of Drosophila proteins. Moreover, an ultimate goal of biology is not just to understand individual gene or protein activities but ..
  5. A Systems Biology Approach To Cardiomyopathy in the D. Melanogaster Model System
    BRIAN O'ROURKE; Fiscal Year: 2013
    ..e. targets for future rapid targeted knockdown and overexpression. Human homologues of these novel modified drosophila proteins may represent novel targets for therapeutic drug design.
  6. Functional and Coevolutionary Analysis of Interacting Reproductive Proteins in Dr
    GEOFFREY DAVID FINDLAY; Fiscal Year: 2013
    ..Thus, the methods used to study the functions of Drosophila proteins and the types of interactions involving these proteins may generate useful techniques and hypotheses for ..
  7. Molecular Characterization of Axon-Glial Interactions
    Manzoor A Bhat; Fiscal Year: 2013
    ..b>Drosophila proteins: Neurexin IV (NRX IV), Contactin (CONT) and Neuroglian (NRG) form a tripartite complex that localizes to ..
  8. METALLOENZYME SYNTHESIS, STRUCTURE AND FUNCTION
    William Konigsberg; Fiscal Year: 1999
    ..Zinc finger" proteins are essential in the process of development and differentiation (several Drosophila proteins controlling developmental destiny are zinc finger proteins), metabolic control (fungal transcription ..
  9. GENETIC MODEL OF NEURODEGENERATION
    Mel Feany; Fiscal Year: 2003
    ..The ability of many Drosophila proteins, including several discussed in the current application, to substitute functionally for their mammalian ..
  10. Molecular Analysis of 5HT Receptor Mediated Signaling
    KERRY GARRITY; Fiscal Year: 2006
    ..It is known that significant structural similarities exist between the mammalian and Drosophila proteins that comprise the serotonergic pathway (i.e. 5HT synthetic enzymes, transporters, and receptors)...
  11. ROLES OF TOLL LIKE RECEPTORS IN INNATE IMMUNITY
    Matthew Fenton; Fiscal Year: 2000
    ..The related Drosophila proteins Toll and 18-Wheeler are required for ani-fungal and anti-bacterial responses in the fly...
  12. Repressible Gal4-UAS expression systems for Drosphila
    James Mohler; Fiscal Year: 2001
    ..proteins, TetR and LexA, will be made by fusing their DNA-binding domains with repression domains from the Drosophila proteins Hairy and Groucho...
  13. ID of Drosophila proteins modified by neural activity
    Mani Ramaswami; Fiscal Year: 2003
    ..In addition, results from these experiments may identify new molecules to targets for pharmacological therapy. ..
  14. ROLES OF TOLL LIKE RECEPTORS IN INNATE IMMUNITY
    Stefanie Vogel; Fiscal Year: 2005
    ..The related Drosophila proteins Toll and 18-Wheeler are required for anti-fungal and anit-bacterial responses in the fly...
  15. TRANSCRIPTIONAL CONTROL OF PANCREATIC DEVELOPMENT
    RAYMOND MACDONALD; Fiscal Year: 2005
    ..can also form a trimeric complex with P48 and an E protein and that this ability is conserved for the Drosophila proteins. We propose that PTF1 containing either SUH or SUH-L and in concert with Notch-signaling may control cell-..
  16. MECHANISMS & REGULATION OF DROSOPHILA P ELEMENT TRANSPST
    Donald Rio; Fiscal Year: 2003
    ..5. Analyze the role of the Drosophila proteins IRBP, DmKup70, DmKup80 and DmDNA-PKcs (p470) in P element transposition. 6...
  17. GERM LINE ESTABLISHMENT IN DROSOPHILA MELANOGASTER
    Paul Lasko; Fiscal Year: 2009
    ..Finally, in the 5th aim the relationship between Tud, a protein essential downstream of Vas for germ line establishment, Cup, a translational regulator, TACC, a microtubule binding protein, and Dynein heavy chain will be examined. ..
  18. Gene Activation by Remote Transcriptional Enhancers
    Dale Dorsett; Fiscal Year: 2004
    ..This will help illuminate the basic mechanisms underlying gene expression defects that occur in some human diseases. ..
  19. AXON GIUDANCE AND TARGETING IN DROSOPHILA
    S Zipursky; Fiscal Year: 2005
    ..As Drosophila Dscam is structurally related to a human gene implicated in Down Syndrome, the studies described in this grant may provide insights into the abnormalities in brain development in Down Syndrome patients. ..
  20. GENETIC ANALYSIS OF PREHAIR MORPHOGENESIS
    Paul Adler; Fiscal Year: 2005
    ....
  21. GORDON RESEARCH CONFERENCE ON NEURAL DEVELOPMENT
    S Zipursky; Fiscal Year: 2002
    ..Participants will be encouraged to present posters, which serves as an excellent training and scientific function. ..
  22. Conference Proposal: Calcium and Cell Function
    Craig Montell; Fiscal Year: 2004
    ..The topics to be covered at the meeting are of fundamental importance and are relevant to understanding the bases of a diseases such as neurodegeneration, communicative disorders, aging, cancer, kidney and cardiovascular disease. ..
  23. Molecular Analysis of Synaptic Transmission Mutants
    William L Pak; Fiscal Year: 2010
    ..Although this work will be carried out using Drosophila because of its experimental tractability, the work is expected to lead to the identification of novel mammalian homologs and insights into their functions. ..
  24. "Model organisms to human biology: strategies for the future of genetic research"
    Allan Spradling; Fiscal Year: 2008
    ..The meeting is expected to attract 300-5000 people. It will be held at the Town and Country Resort, about 10 miles outside of San Diego, All meeting attendees will be housed on- ..
  25. GENETIC DISSECTION OF DENDRITE DEVELOPMENT
    YUH JAN; Fiscal Year: 2009
    ..The Core programs identified from this work will contribute to the understanding and eventual treatment of human neurological diseases many of which have pathology in dendrites. ..
  26. Drosophila Screens for Diabetes and Glucose Toxicity
    Ross Cagan; Fiscal Year: 2007
    ..Together, these genetic and compound screens should provide important functional information and the potential for new treatments. ..
  27. RNAi-directed assembly of heterochromatin in Drosophila
    Sarah Elgin; Fiscal Year: 2008
    ..abstract_text> ..
  28. Analysis of Mitochondrial Morphology and Function
    DENNIS LA JEUNESSE; Fiscal Year: 2007
    ..As AREA grant, this project has been designed to accommodate the training and education of undergraduate researchers. [unreadable] [unreadable] [unreadable]..
  29. The structural basis for APP cleavability
    Ya Ha; Fiscal Year: 2009
    ..abstract_text> ..
  30. Development of tissue-specific cell lines in Drosophila
    Amanda Simcox; Fiscal Year: 2009
    ..Subsequent use of the cell lines by individual investigators to study diverse biological problems is expected to impact our understanding of human disease. ..
  31. Molecular Mechanisms Regulating Drosophila Ovarian Germline Stem Cells
    Ting Xie; Fiscal Year: 2010
    ..Therefore, this proposed study will surely contribute to a better understanding of stem cell biology, cancer formation and aging as well as to using stem cells in future regenerative medicine. ..
  32. Phosphorylation dependent recognition of a histone mRNA hairpin by SLBP
    William Marzluff; Fiscal Year: 2009
    ..abstract_text> ..
  33. Re-engineering the MEGA software package
    Sudhir Kumar; Fiscal Year: 2009
    ..These core software enhancements will contribute to the longevity of MEGA for use in molecular evolution, bioinformatics, functional genomics, computational biology, and basic biomedicine applications. ..
  34. Lysozymes and immunity in Anopheles gambiae
    Susan M Paskewitz; Fiscal Year: 2010
    ....
  35. Presenilins and neuronal calcium signaling
    ILYA B BEZPROZVANNY; Fiscal Year: 2010
    ..These data will also help to evaluate "Ca2+ hypothesis of AD" and will contribute to selecting optimal strategies for treatment of AD. ..
  36. Hormonal Factors and Recruitment of Neurons into the Stress Response Circuitry
    Wendi S Neckameyer; Fiscal Year: 2010
    ..This will provide a unique and innovative approach to modeling the development and organization of the stress circuitry in mammals. ..
  37. Compartmentalized Exosome Structure and Function
    Erik D Andrulis; Fiscal Year: 2010
    ..An in-depth understanding of how the exosome processes and degrades mRNAs is fundamentally important to human health, as aberrant gene expression is an etiological factor in numerous disease states. ..
  38. The Role of Wnt2 in Drosophila Antenna Lobe Development
    Faith Liebl; Fiscal Year: 2007
    ..The aim of this proposal is to investigate the role of Wnt2 in olfactory map formation by determining its cellular function, developmental requirements, and the cell types that express Wnt2. [unreadable] [unreadable] [unreadable]..
  39. SHARED HIGH RESOLUTION MULTIMODE MICROSCOPE SYSTEM
    Greenfield Sluder; Fiscal Year: 2001
    ..The proposed instrument system will allow these researchers to take their investigations in new directions, obtain novel information, and thus, significantly advance their programs in basic biomedical research. ..
  40. Ocular proteomics of retina
    Hiroyuki Matsumoto; Fiscal Year: 2005
    ..Accomplishment of this project will help researchers investigating vision and its disorders at the protein level using rodent models. ..
  41. STRUCTURAL AND FUNCTIONAL LIGAND-BINDING FEATURES OF USP
    Grace Jones; Fiscal Year: 2002
    ....
  42. Analysis of fringe-dependent cell-signaling
    Kenneth Irvine; Fiscal Year: 2004
    ....
  43. 2003 Gordon Research Conference - Biology of Aging
    John Tower; Fiscal Year: 2003
    ..Significant funding is also provided by the Gordon Research Conference Organization, and additional funds are being solicited from private foundations and industry. ..
  44. SYNAPTIC CONNECTIVITY IN CENTRAL BRAIN
    Wayne Johnson; Fiscal Year: 2004
    ..abstract_text> ..
  45. GENETIC CONTROL OF CELL FATE DIVERSITY IN DROSOPHILA
    Amy Bejsovec; Fiscal Year: 2003
    ..This specificity may indicate a novel function in the Wg pathway. Aim 4 describes a plan for the molecular cloning of this new gene and for the subsequent characterization of its gene product. ..
  46. INTERACTIONS OF CALCIUM CHANNELS WITH ADAPTOR PROTEINS
    Ilya Bezprozvanny; Fiscal Year: 2003
    ....
  47. DROSOPHILA LONGEVITY ASSURANCE GENES
    John Tower; Fiscal Year: 2003
    ..PdL creates dominant conditional mutations, which should greatly facilitate the identification, characterization and cloning of novel Drosophila LAGs. ..
  48. Drosophila DNA Replication Origins
    John Tower; Fiscal Year: 2005
    ..The experiments will test a number of specific hypotheses as to the organization and regulation of the chorion locus DNA replication origins. ..
  49. Screen:Blockers of a CaV2.2-Mint-PDZ1 association (RMI)
    Ilya Bezprozvanny; Fiscal Year: 2004
    ..Biological activity of compounds identified in the full HTS screen will be tested in whole animal pain assays (formalin, hot plate, tail flick). ..
  50. Structural studies of bacterial quorum sensing regulator
    Mair Churchill; Fiscal Year: 2005
    ..Study the structures and mechanisms to determine similarities to other AHL synthases. ..
  51. Identification of Genetic Modifiers of an Epstein-Barr Virus Protein.
    AMY ADAMSON; Fiscal Year: 2007
    ..Our studies aim to find human genes whose protein products enhance or suppress Epstein-Barr virus protein activity. [unreadable] [unreadable] [unreadable]..
  52. Screen for molecules inhibiting histone pre-mRNA process
    William Marzluff; Fiscal Year: 2006
    ..We are adapting the screen to an automated microscope which can rapidly read the 384 well plates. ..
  53. The insulin receptor regulates axon guidance
    Leslie Pick; Fiscal Year: 2006
    ..abstract_text> ..
  54. BIAcore 3000 System
    LESLIE GRIFFITH; Fiscal Year: 2002
    ..The salary of the Principal Operator, as well as space in the Facility, and funds for maintenance of the instrument are guaranteed into the foreseeable future. ..
  55. The enhancer of rudimentary gene
    STUART TSUBOTA; Fiscal Year: 2002
    ..The expression data of e(r) suggest that mutants may be embryonic lethals. If this is the case, the mutants will be analyzed for cellular defects in the embryo that that will help uncover the normal function of e(r). ..
  56. GENE REGULATION OF RAT DENTIN SIALOPROTEIN
    HELENA RITCHIE; Fiscal Year: 2006
    ..These ongoing studies, which combine gene regulation and protein function approaches, will reveal underlying mechanisms of dentin mineralization and will later be applicable to reparative dentistry. ..
  57. Cell Cycle Regulation by Checkpoints in Drosophila
    Tin Tin Su; Fiscal Year: 2006
    ..Aim 4) We will screen through existing mutagensensitive Drosophila mutants for their ability to regulate mitosis, S phase and cell death after irradiation, in order to uncover novel genes needed for proper response to DNA damage. ..
  58. PHOSPHOLIPASE C AND CARDIAC HYPERTROPHY
    GERALD DORN; Fiscal Year: 2005
    ..abstract_text> ..
  59. Genetic Modifiers of Epstein-Barr Virus/Host Interactns
    AMY ADAMSON; Fiscal Year: 2003
    ..The results from this genetic screen will shed light onto the mechanisms by which EBV alters normal cellular functions, as well as how genetic predisposition may play a role in EBV-related diseases. ..
  60. Calpains as Mediators of Cardiac Ischemic Injury
    Gerald W Dorn; Fiscal Year: 2010
    ..Collectively, these studies will apply state-of-the-art techniques for in vivo genetic manipulation, microphysiologic analysis, and biochemical assessment to achieve insight into the roles of myocardial calpains in health and disease. ..
  61. Molecular Mechanisms of dendrite development in mammalia
    YUH JAN; Fiscal Year: 2007
    ..The Core programs identified from this work will contribute to the understanding and eventual treatment of human neurological diseases many of which have pathology in dendrites. ..
  62. Visual System Development 2008 Gordon Research Conference
    Ross Cagan; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  63. STRUCTURAL STUDIES OF CHROMOSOMAL PROTEIN/DNA COMPLEXES
    Mair Churchill; Fiscal Year: 2002
    ..Structural studies with HMG-D will be valuable for understanding DNA recognition at a level of detail that will be helpful in the design of improved anti-tumor drugs. ..
  64. SIZE-CONTROL MECHANISMS IN DROSOPHILA DEVELOPMENT
    Duojia Pan; Fiscal Year: 2005
    ..Understanding the molecular mechanisms of dPTEN function will not only provide insights into size control mechanisms in development, but also shed light on how PTEN functions as a tumor suppressor gene in humans. ..