heat shock proteins

Summary

Summary: Proteins which are synthesized in eukaryotic organisms and bacteria in response to hyperthermia and other environmental stresses. They increase thermal tolerance and perform functions essential to cell survival under these conditions.

Top Publications

  1. ncbi Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1
    Z Wu
    Dana Farber Cancer Institute, and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cell 98:115-24. 1999
  2. pmc XBP-1 regulates a subset of endoplasmic reticulum resident chaperone genes in the unfolded protein response
    Ann Hwee Lee
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Mol Cell Biol 23:7448-59. 2003
  3. ncbi GRP78 induction in cancer: therapeutic and prognostic implications
    Amy S Lee
    Department of Biochemistry and Molecular Biology, University of Southern California Norris Comprehensive Cancer Center, University of Southern California Keck School of Medicine, 1441 Eastlake Avenue, Los Angeles, CA 90089, USA
    Cancer Res 67:3496-9. 2007
  4. ncbi Intracellular and extracellular functions of heat shock proteins: repercussions in cancer therapy
    E Schmitt
    Inserm U 517, 7 Boulevard Jeanne d Arc, Faculty of Medicine and Pharmacy, Dijon 21079, France, and Department of Hematology Oncology, University Hospital Regensburg, Germany
    J Leukoc Biol 81:15-27. 2007
  5. pmc Guidelines for the nomenclature of the human heat shock proteins
    Harm H Kampinga
    Department of Cell Biology, Section of Radiation and Stress Cell Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Cell Stress Chaperones 14:105-11. 2009
  6. pmc Adaptation to ER stress is mediated by differential stabilities of pro-survival and pro-apoptotic mRNAs and proteins
    D Thomas Rutkowski
    Howard Hughes Medical Institute, University of Michigan Medical Center, Ann Arbor, Michigan, USA
    PLoS Biol 4:e374. 2006
  7. ncbi Heat shock proteins in cancer: chaperones of tumorigenesis
    Stuart K Calderwood
    Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Trends Biochem Sci 31:164-72. 2006
  8. doi Heat shock proteins and immune system
    Min Fu Tsan
    Office of Research Oversight, Department of Veterans Affairs, 50 Irving Street, N W, Washington, DC 20422, USA
    J Leukoc Biol 85:905-10. 2009
  9. ncbi The ER chaperone and signaling regulator GRP78/BiP as a monitor of endoplasmic reticulum stress
    Amy S Lee
    Department of Biochemistry and Molecular Biology and the USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089 9176, USA
    Methods 35:373-81. 2005
  10. ncbi ER stress regulation of ATF6 localization by dissociation of BiP/GRP78 binding and unmasking of Golgi localization signals
    Jingshi Shen
    Department of Biological Sciences, Columbia University, New York, NY 10027, USA
    Dev Cell 3:99-111. 2002

Detail Information

Publications338 found, 100 shown here

  1. ncbi Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1
    Z Wu
    Dana Farber Cancer Institute, and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cell 98:115-24. 1999
    ..These data elucidate a pathway that directly links external physiological stimuli to the regulation of mitochondrial biogenesis and function...
  2. pmc XBP-1 regulates a subset of endoplasmic reticulum resident chaperone genes in the unfolded protein response
    Ann Hwee Lee
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Mol Cell Biol 23:7448-59. 2003
    ..Further, our observations suggest the existence of additional, as-yet-unknown, key regulators of the UPR...
  3. ncbi GRP78 induction in cancer: therapeutic and prognostic implications
    Amy S Lee
    Department of Biochemistry and Molecular Biology, University of Southern California Norris Comprehensive Cancer Center, University of Southern California Keck School of Medicine, 1441 Eastlake Avenue, Los Angeles, CA 90089, USA
    Cancer Res 67:3496-9. 2007
    ..Furthermore, the recent discovery of GRP78 on the cell surface of cancer cells but not in normal tissues suggests that targeted therapy against cancer via surface GRP78 may be feasible...
  4. ncbi Intracellular and extracellular functions of heat shock proteins: repercussions in cancer therapy
    E Schmitt
    Inserm U 517, 7 Boulevard Jeanne d Arc, Faculty of Medicine and Pharmacy, Dijon 21079, France, and Department of Hematology Oncology, University Hospital Regensburg, Germany
    J Leukoc Biol 81:15-27. 2007
    Stress or heat shock proteins (HSPs) are the most conserved proteins present in both prokaryotes and eukaryotes. Their expression is induced in response to a wide variety of physiological and environmental insults...
  5. pmc Guidelines for the nomenclature of the human heat shock proteins
    Harm H Kampinga
    Department of Cell Biology, Section of Radiation and Stress Cell Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Cell Stress Chaperones 14:105-11. 2009
    ..In addition to this nomenclature, we provide a list of the human Entrez Gene IDs and the corresponding Entrez Gene IDs for the mouse orthologs...
  6. pmc Adaptation to ER stress is mediated by differential stabilities of pro-survival and pro-apoptotic mRNAs and proteins
    D Thomas Rutkowski
    Howard Hughes Medical Institute, University of Michigan Medical Center, Ann Arbor, Michigan, USA
    PLoS Biol 4:e374. 2006
    ..It underscores the contribution of posttranscriptional and posttranslational mechanisms in influencing this outcome...
  7. ncbi Heat shock proteins in cancer: chaperones of tumorigenesis
    Stuart K Calderwood
    Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Trends Biochem Sci 31:164-72. 2006
    The heat shock proteins (HSPs) induced by cell stress are expressed at high levels in a wide range of tumors and are closely associated with a poor prognosis and resistance to therapy...
  8. doi Heat shock proteins and immune system
    Min Fu Tsan
    Office of Research Oversight, Department of Veterans Affairs, 50 Irving Street, N W, Washington, DC 20422, USA
    J Leukoc Biol 85:905-10. 2009
    b>Heat shock proteins (HSPs) such as HSP 60 (Hsp60), Hsp70, Hsp90, and gp96, have been reported to play important roles in antigen presentation and cross-presentation, activation of macrophages and lymphocytes, and activation and ..
  9. ncbi The ER chaperone and signaling regulator GRP78/BiP as a monitor of endoplasmic reticulum stress
    Amy S Lee
    Department of Biochemistry and Molecular Biology and the USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089 9176, USA
    Methods 35:373-81. 2005
    ..This can be achieved by measuring the Grp78 promoter activity or by measuring the level of Grp78 transcripts or GRP78 protein. These techniques can be applied to tissue culture cells as well as tissues and organs...
  10. ncbi ER stress regulation of ATF6 localization by dissociation of BiP/GRP78 binding and unmasking of Golgi localization signals
    Jingshi Shen
    Department of Biological Sciences, Columbia University, New York, NY 10027, USA
    Dev Cell 3:99-111. 2002
    ..These results suggest that BiP retains ATF6 in the ER by inhibiting its GLSs and that dissociation of BiP during ER stress allows ATF6 to be transported to the Golgi...
  11. ncbi Regulated translation initiation controls stress-induced gene expression in mammalian cells
    H P Harding
    Skirball Institute of Biomolecular Medicine The Department of Medicine, Kaplan Cancer Center New York University School of Medicine, New York, NY 10016, USA
    Mol Cell 6:1099-108. 2000
    ..Mammalian cells thus utilize an ancient pathway to regulate gene expression in response to diverse stress signals...
  12. ncbi Heat shock proteins: modifying factors in physiological stress responses and acquired thermotolerance
    Kevin C Kregel
    Integrative Physiology Laboratory, Department of Exercise Science, The University of Iowa, Iowa City 52242, USA
    J Appl Physiol (1985) 92:2177-86. 2002
    ..respond to a variety of stresses by the rapid synthesis of a highly conserved set of polypeptides termed heat shock proteins (HSPs)...
  13. pmc Genetic and environmental factors affecting the de novo appearance of the [PSI+] prion in Saccharomyces cerevisiae
    I L Derkatch
    Department of Biological Sciences, University of Illinois at Chicago 60607, USA
    Genetics 147:507-19. 1997
    ....
  14. ncbi The unfolded protein response regulator GRP78/BiP as a novel target for increasing chemosensitivity in malignant gliomas
    Peter Pyrko
    Department of Pathology, and University of Southern California Norris Comprehensive Cancer Center, University of Southern California Keck School of Medicine, Los Angeles, California 90033, USA
    Cancer Res 67:9809-16. 2007
    ....
  15. ncbi Hsp104, Hsp70, and Hsp40: a novel chaperone system that rescues previously aggregated proteins
    J R Glover
    Howard Hughes Medical Institute and Department of Molecular Genetics and Cell Biology, The University of Chicago, Illinois 60637, USA
    Cell 94:73-82. 1998
    ..coli. We conclude that Hsp104 has a protein remodeling activity that acts on trapped, aggregated proteins and requires specific interactions with conventional chaperones to promote refolding of the intermediates it produces...
  16. ncbi Heat shock proteins: endogenous modulators of apoptotic cell death
    C Garrido
    Inserm U 517, Faculty of Medicine and Pharmacy, 7, boulevard Jeanne d Arc, Dijon, 21033, France
    Biochem Biophys Res Commun 286:433-42. 2001
    The highly conserved heat shock proteins (HSPs) accumulate in cells exposed to heat and a variety of other stressful stimuli...
  17. pmc Feedback inhibition of the unfolded protein response by GADD34-mediated dephosphorylation of eIF2alpha
    I Novoa
    Skirball Institute of Biomolecular Medicine, Department of Medicine, New York University School of Medicine, New York, NY 10016, USA
    J Cell Biol 153:1011-22. 2001
    ....
  18. ncbi The mammalian unfolded protein response
    Martin Schroder
    School of Biological and Biomedical Sciences, University of Durham, Durham DH1 3LE, United Kingdom
    Annu Rev Biochem 74:739-89. 2005
    ..Finally, we summarize data that demonstrate that UPR signaling feeds into decision making in other processes previously thought to be unrelated to ER function, e.g., eukaryotic starvation responses and differentiation programs...
  19. doi Proteomics applied on plant abiotic stresses: role of heat shock proteins (HSP)
    Anna Maria Timperio
    Department of Environmental Sciences, University of Tuscia, Largo dell Università snc, 01100 Viterbo, Italy
    J Proteomics 71:391-411. 2008
    ..beside specific proteins production, plants respond to various stresses in a similar manner by producing heat shock proteins (HSPs), indicating a similarity in the plant's adaptive mechanisms; in plants, more than in animals, HSPs ..
  20. ncbi Endoplasmic reticulum chaperone protein GRP78 protects cells from apoptosis induced by topoisomerase inhibitors: role of ATP binding site in suppression of caspase-7 activation
    Ramachandra K Reddy
    Department of Biochemistry and Molecular Biology and the USC Norris Comprehensive Cancer Center, University of Southern California Keck School of Medicine, Los Angeles, California 90089 9176, USA
    J Biol Chem 278:20915-24. 2003
    ..Lastly, a GRP78 mutant deleted of its ATP binding domain fails to bind procaspase-7 and loses its protective effect against etoposide-induced apoptosis...
  21. ncbi The ER function BiP is a master regulator of ER function
    Linda M Hendershot
    Department of Genetics and Tumor Cell Biology, St Jude Children s Research Hospital, 332 N Lauderdale, Memphis, TN 38105, USA
    Mt Sinai J Med 71:289-97. 2004
    ....
  22. ncbi Hsp90 as a capacitor for morphological evolution
    S L Rutherford
    Howard Hughes Medical Institute, University of Chicago, Illinois 60637, USA
    Nature 396:336-42. 1998
    ..This provides a plausible mechanism for promoting evolutionary change in otherwise entrenched developmental processes...
  23. ncbi Heat-shock proteins, molecular chaperones, and the stress response: evolutionary and ecological physiology
    M E Feder
    Department of Organismal Biology and Anatomy and Committee on Evolutionary Biology, University of Chicago, Illinois 60637, USA
    Annu Rev Physiol 61:243-82. 1999
    ....
  24. pmc A heat-inducible transcription factor, HsfA2, is required for extension of acquired thermotolerance in Arabidopsis
    Yee Yung Charng
    Agricultural Biotechnology Research Center, Academia Sinica, Taipei 11529, Taiwan, ROC
    Plant Physiol 143:251-62. 2007
    The expression of heat shock proteins (Hsps) induced by nonlethal heat treatment confers acquired thermotolerance (AT) to organisms against subsequent challenges of otherwise lethal temperature...
  25. pmc The unfolded protein response regulator GRP78/BiP is required for endoplasmic reticulum integrity and stress-induced autophagy in mammalian cells
    J Li
    Department of Biochemistry and Molecular Biology, USC Norris Comprehensive Cancer Center, University of Southern California Keck School of Medicine, Los Angeles, CA 90089, USA
    Cell Death Differ 15:1460-71. 2008
    ..Thus, these studies uncover 3-MA as an inhibitor of UPR activation and establish GRP78 as a novel obligatory component of autophagy in mammalian cells...
  26. ncbi Saccharomyces cerevisiae Hsp104 protein. Purification and characterization of ATP-induced structural changes
    D A Parsell
    Department of Molecular Genetics and Cell Biology, University of Chicago, Illinois 60637
    J Biol Chem 269:4480-7. 1994
    ..More strikingly, the assembly and maintenance of Hsp104 particles are dependent upon the presence of adenine nucleotides. Oligomerization appears to primarily depend upon the second of the two ATP-binding sites in the protein...
  27. ncbi Heat shock proteins in the regulation of apoptosis: new strategies in tumor therapy: a comprehensive review
    Amere Subbarao Sreedhar
    Department of Medical Chemistry, Semmelweis University, P O Box 260, H 1444 Budapest, Hungary
    Pharmacol Ther 101:227-57. 2004
    b>Heat shock proteins (Hsp) form the most ancient defense system in all living organisms on earth...
  28. pmc hsp82 is an essential protein that is required in higher concentrations for growth of cells at higher temperatures
    K A Borkovich
    Howard Hughes Medical Institute, University of Chicago, Illinois 60637
    Mol Cell Biol 9:3919-30. 1989
    hsp82 is one of the most highly conserved and abundantly synthesized heat shock proteins of eucaryotic cells. The yeast Saccharomyces cerevisiae contains two closely related genes in the HSP82 gene family...
  29. doi Heat shock proteins in toxicology: how close and how far?
    Subash C Gupta
    Embryotoxicology Section, Indian Institute of Toxicology Research, Lucknow, India
    Life Sci 86:377-84. 2010
    ..of this response a set of genes called stress genes are induced to synthesize a group of proteins called heat shock proteins (Hsps)...
  30. ncbi Heat shock proteins 27 and 70: anti-apoptotic proteins with tumorigenic properties
    Carmen Garrido
    Inserm U 517, Faculty of Medicine and Pharmacy, Université de Dijon, Dijon, France
    Cell Cycle 5:2592-601. 2006
    b>Heat shock proteins (HSP) HSP27 and HSP70 are expressed in response to a wide variety of physiological and environmental insults including anticancer chemotherapy, thus allowing the cell to survive to lethal conditions...
  31. ncbi Endoplasmic reticulum stress contributes to beta cell apoptosis in type 2 diabetes
    D R Laybutt
    Diabetes and Obesity Research Program, Garvan Institute of Medical Research, St Vincent s Hospital, Sydney, NSW, Australia
    Diabetologia 50:752-63. 2007
    ..We investigated whether endoplasmic reticulum (ER) stress is necessary for lipid-induced apoptosis in beta cells and also whether ER stress is present in islets of an animal model of diabetes and of humans with type 2 diabetes...
  32. ncbi On the role of Hsp27 in regulating apoptosis
    C G Concannon
    Department of Biochemistry and National Centre for Biomedical Engineering Science, National University of Ireland, Galway, Ireland
    Apoptosis 8:61-70. 2003
    b>Heat shock proteins (Hsps) comprise several different families of proteins that are induced in response to a wide variety of physiological and environmental insults...
  33. ncbi "The stress of dying": the role of heat shock proteins in the regulation of apoptosis
    Helen M Beere
    La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, CA 92121, USA
    J Cell Sci 117:2641-51. 2004
    b>Heat shock proteins (Hsps) are a family of highly homologous chaperone proteins that are induced in response to environmental, physical and chemical stresses and that limit the consequences of damage and facilitate cellular recovery...
  34. pmc Arabidopsis and the heat stress transcription factor world: how many heat stress transcription factors do we need?
    L Nover
    Biocenter of the Goethe University, Frankfurt Main, Germany
    Cell Stress Chaperones 6:177-89. 2001
    ..We have speculated about possible exon-intron borders in this region in the ancient precursor gene of plant Hsfs, similar to the exon-intron structure of the present mammalian Hsf-encoding genes...
  35. ncbi Hsp104 catalyzes formation and elimination of self-replicating Sup35 prion conformers
    James Shorter
    Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142, USA
    Science 304:1793-7. 2004
    ..These Hsp104 activities differed in their reaction mechanism and can explain [PSI+] inheritance patterns...
  36. ncbi Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response
    A Bertolotti
    Skirball Institute of Biomolecular Medicine, Departments of Medicine and Cell Biology and the Kaplan Cancer Center, New York University School of Medicine, New York, New York 10016, USA
    Nat Cell Biol 2:326-32. 2000
    ..These findings are consistent with a model in which BiP represses signalling through PERK and IRE1 and protein misfolding relieves this repression by effecting the release of BiP from the PERK and IRE1 lumenal domains...
  37. doi ERdj5 is required as a disulfide reductase for degradation of misfolded proteins in the ER
    Ryo Ushioda
    Department of Molecular and Cellular Biology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606 8397, Japan
    Science 321:569-72. 2008
    ..Thus, ERdj5 is a member of a supramolecular ERAD complex that recognizes and unfolds misfolded proteins for their efficient retrotranslocation...
  38. pmc Functional coupling of p38-induced up-regulation of BiP and activation of RNA-dependent protein kinase-like endoplasmic reticulum kinase to drug resistance of dormant carcinoma cells
    Aparna C Ranganathan
    Department of Biomedical Sciences, School of Public Health and Center for Excellence in Cancer Genomics, University at Albany, State University of New York, Rensselaer, NY 12144, USA
    Cancer Res 66:1702-11. 2006
    ..We propose that stress-dependent activation of p38 via BiP up-regulation and PERK activation protects dormant tumor cells from stress insults, such as chemotherapy...
  39. pmc Heat shock proteins: molecular chaperones of protein biogenesis
    E A Craig
    Department of Biomolecular Chemistry, University of Wisconsin Madison 53706
    Microbiol Rev 57:402-14. 1993
    b>Heat shock proteins (Hsps) were first identified as proteins whose synthesis was enhanced by stresses such as an increase in temperature...
  40. ncbi Escaping cell death: survival proteins in cancer
    M Jaattela
    Institute of Cancer Biology, Danish Cancer Society, Strandboulevarden 49, Copenhagen, DK 2100, Denmark
    Exp Cell Res 248:30-43. 1999
    ..Proteins fulfilling these criteria include antiapoptotic members of the Bcl-2 protein family, heat shock proteins, Hsp70 and Hsp27, as well as survivin, the novel cancer-associated member of the inhibitor of apoptosis ..
  41. ncbi Molecular chaperones and the stress of oncogenesis
    Dick D Mosser
    Department of Molecular Biology and Genetics, University of Guelph, Guelph, Ontario, Canada N1G 2W1
    Oncogene 23:2907-18. 2004
    ..The involvement of chaperones, therefore, in such diverse roles might suggest novel anticancer therapeutic approaches targeting heat-shock protein function for a broad spectrum of tumor types...
  42. ncbi Heat shock proteins as cellular lifeguards
    M Jaattela
    Apoptosis Laboratory, Institute of Cancer Biology, Danish Cancer Society, Copenhagen
    Ann Med 31:261-71. 1999
    ..The heat shock or stress response, ie the synthesis of heat shock proteins (Hsps, stress proteins) in response to a mild stress, allows cells to adapt to gradual changes in their ..
  43. ncbi Heat stress response in plants: a complex game with chaperones and more than twenty heat stress transcription factors
    Sanjeev Kumar Baniwal
    Department of Molecular Cell Biology, Goethe University Frankfurt, Marie Curie Str 9, D 60439 Frankfurt M, Germany
    J Biosci 29:471-87. 2004
    ..But in addition, it cooperates with yet to be identified other transcription factors in maintaining and/or restoring housekeeping gene expression...
  44. pmc Inflammation, heat shock proteins, and type 2 diabetes
    Philip L Hooper
    Department of Endocrinology, University of Colorado Denver, School of Medicine, Aurora, CO, USA
    Cell Stress Chaperones 14:113-5. 2009
    ..A crucial and previously under-recognized event contributing to this loss of homeostasis is a reduction in heat shock proteins (HSPs, or stress proteins)...
  45. ncbi Heat shock proteins: facts, thoughts, and dreams
    A De Maio
    Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Shock 11:1-12. 1999
    ..The intrinsic capacity of hsps to protect cells has potential relevance as a natural mechanism of organ protection during harmful environmental conditions and operative procedures, and in the combat against pathogens...
  46. pmc Regulation of longevity in Caenorhabditis elegans by heat shock factor and molecular chaperones
    James F Morley
    Department of Biochemistry, Molecular Biology, and Cell Biology, Rice Institute for Biomedical Research, Northwestern University, Evanston, Illinois 60208, USA
    Mol Biol Cell 15:657-64. 2004
    ..The interaction of ILS with HSF-1 could represent an important molecular strategy to couple the regulation of longevity with an ancient genetic switch that governs the ability of cells to sense and respond to stress...
  47. ncbi DnaK and DnaJ heat shock proteins participate in protein export in Escherichia coli
    J Wild
    Department of Bacteriology, University of Wisconsin Madison 53706
    Genes Dev 6:1165-72. 1992
    ..We report results indicating that the DnaK and DnaJ heat shock proteins are also involved in the export of several proteins, most likely by acting as their chaperones...
  48. ncbi Extracellular heat shock proteins in cell signaling
    Stuart K Calderwood
    Department of Radiation Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    FEBS Lett 581:3689-94. 2007
    Extracellular stress proteins including heat shock proteins (Hsp) and glucose regulated proteins (Grp) are emerging as important mediators of intercellular signaling and transport...
  49. ncbi Proteomic study reveals that proteins involved in metabolic and detoxification pathways are highly expressed in HER-2/neu-positive breast cancer
    Daohai Zhang
    Department of Laboratory Medicine, National University Hospital, 5 Lower Kent Ridge Road, Singapore 119074
    Mol Cell Proteomics 4:1686-96. 2005
    ....
  50. ncbi Mycobacterium tuberculosis heat shock proteins use diverse Toll-like receptor pathways to activate pro-inflammatory signals
    Yonca Bulut
    Division of Pediatric Critical Care, Cedars Sinai Medical Center, David Geffen School of Medicine at UCLA, Los Angeles, California 90048, USA
    J Biol Chem 280:20961-7. 2005
    ..tuberculosis heat shock proteins are not. An efficient immune response against the intracellular pathogen M...
  51. pmc Structure and mechanism of protein stability sensors: chaperone activity of small heat shock proteins
    Hassane S McHaourab
    Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee 37232 0615, USA
    Biochemistry 48:3828-37. 2009
    Small heat shock proteins (sHSP) make up a remarkably diverse group of molecular chaperones possessing a degree of structural plasticity unparalleled in other protein superfamilies...
  52. doi Heat shock proteins and immunity: application of hyperthermia for immunomodulation
    Toshihiko Torigoe
    Department of Pathology, Sapporo Medical University School of Medicine, Sapporo, Japan
    Int J Hyperthermia 25:610-6. 2009
    b>Heat shock proteins (HSPs) play an important role as 'endogenous danger signals' in the immune surveillance system...
  53. pmc Heat shock proteins in breast cancer progression--a suitable case for treatment?
    Stuart K Calderwood
    Molecular and Cellular Radiation Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Int J Hyperthermia 26:681-5. 2010
    b>Heat shock proteins (HSP) and heat shock factor 1 (HSF1), key factors in the heat shock response (HSR) have been implicated in the etiology of breast cancer...
  54. ncbi Active HSF1 significantly suppresses polyglutamine aggregate formation in cellular and mouse models
    Mitsuaki Fujimoto
    Department of Biochemistry and Molecular Biology, Yamaguchi University School of Medicine, Ube 775 8505, Japan
    J Biol Chem 280:34908-16. 2005
    ..These results indicated that active HSF1 has a strong inhibitory effect on polyglutamine aggregate formation in vivo and in vitro...
  55. pmc Heat shock proteins in cancer: diagnostic, prognostic, predictive, and treatment implications
    Daniel R Ciocca
    Oncology Laboratory, Institute of Experimental Medicine and Biology of Cuyo CRICYT CONICET, Mendoza, Argentina
    Cell Stress Chaperones 10:86-103. 2005
    b>Heat shock proteins (Hsps) are overexpressed in a wide range of human cancers and are implicated in tumor cell proliferation, differentiation, invasion, metastasis, death, and recognition by the immune system...
  56. ncbi Heat shock proteins in cancer
    Michael Sherman
    Department of Biochemistry, Boston University School of Medicine, Massachusetts, USA
    Ann N Y Acad Sci 1113:192-201. 2007
    b>Heat shock proteins (Hsps) are highly conserved and inhabit nearly all subcellular locations where they perform a variety of chaperoning functions including folding and unfolding of nascent polypeptides, proteins, transport of proteins, ..
  57. ncbi Between genotype and phenotype: protein chaperones and evolvability
    Suzanne L Rutherford
    Division of Basic Sciences, Fred Hutchinson Cancer Research Centre, Mailstop A2 168, 1100 Fairview Avenue North, Seattle, Washington 98109 1024, USA
    Nat Rev Genet 4:263-74. 2003
    ..Environmentally sensitive chaperone functions in protein folding and signal transduction have different potential consequences for the evolution of populations and lineages under selection in changing environments...
  58. ncbi The heat stress transcription factor HsfA2 serves as a regulatory amplifier of a subset of genes in the heat stress response in Arabidopsis
    Franziska Schramm
    Institute of Molecular Bio Sciences, Biocenter N200 R306, Goethe University, Marie Curie Str 9, D 60439, Frankfurt, Germany
    Plant Mol Biol 60:759-72. 2006
    ..The results presented here demonstrate that the expression of HsfA2 in Arabidopsis is strictly heat stress-dependent and this transcription factor represents a regulator of a subset of stress response genes in Arabidopsis...
  59. ncbi An Hsp70-like protein in the ER: identity with the 78 kd glucose-regulated protein and immunoglobulin heavy chain binding protein
    S Munro
    Cell 46:291-300. 1986
    ..We propose a specific role for this protein in the assembly of secreted and membrane-bound proteins...
  60. ncbi Cell surface expression of the stress response chaperone GRP78 enables tumor targeting by circulating ligands
    Marco A Arap
    The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Cancer Cell 6:275-84. 2004
    ..Together, these preclinical data validate GRP78 on the tumor cell surface as a functional molecular target that may prove useful for translation into clinical applications...
  61. ncbi Role of heat shock proteins in atherosclerosis
    Qingbo Xu
    Department of Cardiological Sciences, St George s Hospital Medical School, London, UK mail
    Arterioscler Thromb Vasc Biol 22:1547-59. 2002
    b>Heat shock proteins (HSPs) are present in most cells, serving as molecular chaperones, and they play a role in cell protection from damage in response to stress stimuli...
  62. pmc Heat stress phenotypes of Arabidopsis mutants implicate multiple signaling pathways in the acquisition of thermotolerance
    Jane Larkindale
    Department of Biochemistry and Molecular Biophysics, University of Arizona, Tucson, Arizona 85721, USA
    Plant Physiol 138:882-97. 2005
    ..All mutants accumulated wild-type levels of heat shock protein 101 and small heat shock proteins. These data indicate that, separate from heat shock protein induction, ABA, active oxygen species, and ..
  63. ncbi Listeriolysin O: a phagosome-specific lysin
    Pamela Schnupf
    Graduate Group in Microbiology, University of California, Berkeley, CA 94720 3202, USA
    Microbes Infect 9:1176-87. 2007
    ..In this review, we focus primarily on the role of LLO in phagosomal escape and the multiple regulatory mechanisms that control LLO activity in the host cytosol...
  64. ncbi Different efficiency of heat shock proteins (HSP) to activate human monocytes and dendritic cells: superiority of HSP60
    Karen Bethke
    First Department of Internal Medicine and Department of Dermatology, Johannes Gutenberg Universitat, Mainz, Germany
    J Immunol 169:6141-8. 2002
    ..These findings show that HSP can differ considerably in the capacity to activate monocyte-derived APC under certain conditions and underline the potential of HSP60 and HSP72 as activation signals for the innate immune system...
  65. pmc GRP78/BiP is required for cell proliferation and protecting the inner cell mass from apoptosis during early mouse embryonic development
    Shengzhan Luo
    Department of Biochemistry and Molecular Biology and the USC Norris Comprehensive Cancer Center, Keck School of Medicine of the University of Southern California, Los Angeles, CA 90089 9176, USA
    Mol Cell Biol 26:5688-97. 2006
    ..These findings provide the first evidence that GRP78 is essential for embryonic cell growth and pluripotent cell survival...
  66. ncbi Stress induction of GRP78/BiP and its role in cancer
    Jianze Li
    Department of Biochemistry and Molecular Biology, USC Norris Comprehensive Cancer Center, University of Southern California Keck School of Medicine, Los Angeles, 90089 9176, USA
    Curr Mol Med 6:45-54. 2006
    ..This review summarizes the transcriptional regulation of Grp78, the molecular basis for the cytoprotective function of GRP78 and its role in cancer progression, drug resistance and potential future cancer therapy...
  67. ncbi Thermotolerance requires refolding of aggregated proteins by substrate translocation through the central pore of ClpB
    Jimena Weibezahn
    Zentrum fur Molekulare Biologie der Universitat Heidelberg, Universitat Heidelberg, Im Neuenheimer Feld 282, Heidelberg D 69120, Germany
    Cell 119:653-65. 2004
    ..The activity switch of BAP to a degrading disaggregase does not support thermotolerance development, demonstrating that cell survival during severe thermal stress requires reactivation of aggregated proteins...
  68. ncbi Protein disaggregation mediated by heat-shock protein Hsp104
    D A Parsell
    Department of Molecular Genetics and Cell Biology, Howard Hughes Medical Institute, University of Chicago, Illinois 60637
    Nature 372:475-8. 1994
    ..Rather, Hsp104 functions in a manner not previously described for other heat-shock proteins: it mediates the resolubilization of heat-inactivated luciferase from insoluble aggregates...
  69. ncbi Soluble factors from Lactobacillus GG activate MAPKs and induce cytoprotective heat shock proteins in intestinal epithelial cells
    Yun Tao
    Martin Boyer and IBD Research Center, University of Chicago, 5841 S Maryland Ave, MC6084, IL 60637, USA
    Am J Physiol Cell Physiol 290:C1018-30. 2006
    ....
  70. ncbi Evidence for an unfolding/threading mechanism for protein disaggregation by Saccharomyces cerevisiae Hsp104
    Ronnie Lum
    Department of Biochemistry, University of Toronto, Toronto, Ontario M5S 1A8, Canada
    J Biol Chem 279:29139-46. 2004
    ....
  71. pmc In the complex family of heat stress transcription factors, HsfA1 has a unique role as master regulator of thermotolerance in tomato
    Shravan Kumar Mishra
    Biocenter of the Goethe University, D 60439 Frankfurt am Main, Germany
    Genes Dev 16:1555-67. 2002
    ..Thermotolerance in CS protoplasts was restored by plasmid-borne HsfA2, resulting in expression of chaperones, thermoprotection of firefly luciferase, and assembly of heat stress granules...
  72. doi Arabidopsis thaliana J-class heat shock proteins: cellular stress sensors
    Vinoth Babu V Rajan
    Biochemistry Department, Indian Institute of Science, Bangalore, India
    Funct Integr Genomics 9:433-46. 2009
    ..These heat shock proteins are most ubiquitous types of chaperone machineries involved in diverse cellular processes including protein ..
  73. pmc Transcriptional profiling of maturing tomato (Solanum lycopersicum L.) microspores reveals the involvement of heat shock proteins, ROS scavengers, hormones, and sugars in the heat stress response
    Gil Frank
    Department of Vegetable Research, Institute of Plant Sciences, The Volcani Center, Agricultural Research Organization, Bet Dagan, Israel
    J Exp Bot 60:3891-908. 2009
    ..This work provides a comprehensive analysis of the molecular events underlying the HSR of maturing microspores of a crop plant, tomato...
  74. ncbi Role of plant heat-shock proteins and molecular chaperones in the abiotic stress response
    Wangxia Wang
    The Robert H Smith Institute of Plant Sciences and Genetics in Agriculture, Faculty of Agricultural, Food and Environmental Quality Sciences, The Hebrew University of Jerusalem, PO Box 12, Rehovot 76100, Israel
    Trends Plant Sci 9:244-52. 2004
  75. doi Induction of heat shock proteins for protection against oxidative stress
    Bernadett Kalmar
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College London, Queen Square, London, UK
    Adv Drug Deliv Rev 61:310-8. 2009
    b>Heat shock proteins (Hsps) have been studied for many years and there is now a large body of evidence that demonstrates the role of Hsp upregulation in tissue and cell protection in a wide variety of stress conditions...
  76. ncbi Molecular chaperones and protein quality control
    Bernd Bukau
    Zentrum fur Molekulare Biologie, Universitat Heidelberg, 69120 Heidelberg, Germany
    Cell 125:443-51. 2006
    ....
  77. pmc Protection against heat stress-induced oxidative damage in Arabidopsis involves calcium, abscisic acid, ethylene, and salicylic acid
    Jane Larkindale
    Department of Plant Sciences, University of Oxford, South Parks Road, Oxford OX1 3RB, United Kingdom
    Plant Physiol 128:682-95. 2002
    ..Calcium channel blockers and calmodulin inhibitors added solely during the recovery phase suggest that this role for calcium is in protecting against oxidative damage specifically during/after recovery...
  78. ncbi Induction of Grp78/BiP by translational block: activation of the Grp78 promoter by ATF4 through and upstream ATF/CRE site independent of the endoplasmic reticulum stress elements
    Shengzhan Luo
    Department of Biochemistry and Molecular Biology, University of Southern California Keck School of Medicine, Los Angeles, California 90089 9176, USA
    J Biol Chem 278:37375-85. 2003
    ..Our studies resolve a mechanism responsible for inhibition of Grp78 mRNA induction by ER stress in cells that are functionally null for PERK or devoid of eIF2alpha phosphorylation...
  79. ncbi Mutant small heat-shock protein 27 causes axonal Charcot-Marie-Tooth disease and distal hereditary motor neuropathy
    Oleg V Evgrafov
    Department of Psychiatry, New York State Psychiatric Institute Research Foundation for Mental Hygiene, Unit 28, 1051 Riverside Drive, New York, New York 10032, USA
    Nat Genet 36:602-6. 2004
    ..Cotransfection of neurofilament light chain (NEFL) and mutant HSPB1 resulted in altered neurofilament assembly in cells devoid of cytoplasmic intermediate filaments...
  80. doi Plasmodial heat shock proteins: targets for chemotherapy
    Addmore Shonhai
    Department of Biochemistry and Microbiology, Zululand University, KwaDlangezwa, South Africa
    FEMS Immunol Med Microbiol 58:61-74. 2010
    b>Heat shock proteins act as molecular chaperones, facilitating protein folding in cells of living organisms...
  81. pmc Coupling endoplasmic reticulum stress to the cell death program: role of the ER chaperone GRP78
    Rammohan V Rao
    Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, CA 94945 1400, USA
    FEBS Lett 514:122-8. 2002
    ..These results define a novel protective role for GRP78 in preventing ER stress-induced cell death...
  82. ncbi Identification of novel heat shock factor-dependent genes and biochemical pathways in Arabidopsis thaliana
    Wolfgang Busch
    Zentrum für Molekularbiologie der Pflanzen ZMBP, Allgemeine Genetik, Universitat Tubingen, Auf der Morgenstelle 28, D 72076 Tubingen, Germany
    Plant J 41:1-14. 2005
    ..HsfA1a and HsfA1b-regulated gene expression also affects other pathways and mechanisms dealing with a broader range of physiological adaptations to stress...
  83. ncbi Interaction of heat shock proteins with peptides and antigen presenting cells: chaperoning of the innate and adaptive immune responses
    Pramod Srivastava
    Center for Immunotherapy of Cancer and Infectious Diseases, University of Connecticut School of Medicine, Farmington, Connecticut 06030 1601, USA
    Annu Rev Immunol 20:395-425. 2002
    b>Heat shock proteins are abundant soluble intracellular proteins, present in all cells. Members of the heat shock protein family bind peptides including antigenic peptides generated within cells...
  84. ncbi HSP104 required for induced thermotolerance
    Y Sanchez
    Howard Hughes Medical Institute, Department of Molecular Genetics and Cell Biology, University of Chicago, Illinois 60637
    Science 248:1112-5. 1990
    ..Transformation with the wild-type gene rescued the defect of mutant cells. The results demonstrate that a particular heat shock protein plays a critical role in cell survival at extreme temperatures...
  85. pmc Cardiovascular disease delay in centenarian offspring: role of heat shock proteins
    Dellara F Terry
    Deputy Chief, Center for Molecular Stress Response, Boston Medical Center and Boston University School of Medicine, 650 Albany Street, Boston, MA 02118
    Ann N Y Acad Sci 1019:502-5. 2004
    ..We hypothesize that low levels of circulating serum HSP70 may be an indicator of a healthy state and point to longevity of the host; therefore, our results suggest that levels of circulating serum HSP70 may be a marker for longevity...
  86. ncbi Heat shock proteins, cellular chaperones that modulate mitochondrial cell death pathways
    Arnaud Parcellier
    Inserm U 517, Faculty of Medicine and Pharmacy, 7 Boulevard Jeanne d Arc, 21033 Dijon, France
    Biochem Biophys Res Commun 304:505-12. 2003
    Stress or heat shock proteins (HSPs) are ubiquitous and highly conserved proteins whose expression is induced in response to a wide variety of physiological and environmental insults...
  87. pmc Induced autoimmunity to heat shock proteins elicits glaucomatous loss of retinal ganglion cell neurons via activated T-cell-derived fas-ligand
    Martin B Wax
    Ophthalmology Discovery Research, Alcon Corporation, Fort Worth, Texas 76134, USA
    J Neurosci 28:12085-96. 2008
    ..One hypothesis involves heat shock proteins (HSPs), because increased serum levels of HSP autoantibodies are prominent in some glaucoma patients with ..
  88. pmc Mitochondrial adaptations to NaCl. Complex I is protected by anti-oxidants and small heat shock proteins, whereas complex II is protected by proline and betaine
    E W Hamilton
    Department of Biology, Syracuse University, 130 College Place, Syracuse, New York 13244 1220, USA
    Plant Physiol 126:1266-74. 2001
    ..alpha-tocopherol), antioxidant enzymes (catalase and Cu/Zn-superoxide dismutase), and mitochondrial small heat shock proteins (sHsps)...
  89. pmc Alpha-crystallin-type heat shock proteins: socializing minichaperones in the context of a multichaperone network
    Franz Narberhaus
    Institut fur Mikrobiologie, Eidgenossische Technische Hochschule, CH 8092 Zurich, Switzerland
    Microbiol Mol Biol Rev 66:64-93; table of contents. 2002
    ..are induced by a temperature upshift in many organisms, they are often referred to as small heat shock proteins (sHsps) or, more accurately, alpha-Hsps...
  90. ncbi Hsp27 negatively regulates cell death by interacting with cytochrome c
    J M Bruey
    Inserm U 517, Faculty of Medicine and Pharmacy, 7 Boulevard Jeanne d Arc, 21033 Dijon, France
    Nat Cell Biol 2:645-52. 2000
    ..Thus, Hsp27 interferes specifically with the mitochondrial pathway of caspase-dependent cell death...
  91. pmc Control of PERK eIF2alpha kinase activity by the endoplasmic reticulum stress-induced molecular chaperone P58IPK
    Wei Yan
    Departments of Microbiology and Laboratory Medicine, School of Medicine, and Washington National Primate Research Center, University of Washington, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 99:15920-5. 2002
    ..Our studies suggest that P58(IPK) induction during the ER-stress response represses PERK activity and plays a functional role in the expression of downstream markers of PERK activity in the later phase of the ER-stress response...
  92. pmc Heat shock proteins: essential proteins for apoptosis regulation
    D Lanneau
    INSERM, UMR866, Dijon, France
    J Cell Mol Med 12:743-61. 2008
    ..intrinsic apoptotic stimuli induce the accumulation in the cells of a set of proteins known as stress or heat shock proteins (HSPs). HSPs are conserved proteins present in both prokaryotes and eukaryotes...
  93. ncbi Heat shock proteins and protection of the nervous system
    Ian R Brown
    Center for the Neurobiology of Stress, University of Toronto at Scarborough, 1265 Military Trail, Toronto, Ontario, Canada M1C 1A4
    Ann N Y Acad Sci 1113:147-58. 2007
    ..Arimoclomol, a coinducer of heat shock proteins, delayed progression of amyotrophic lateral sclerosis (ALS) in a mouse model in which motor neurons in the ..
  94. ncbi Activation and cross-talk between Akt, NF-kappaB, and unfolded protein response signaling in 1-LN prostate cancer cells consequent to ligation of cell surface-associated GRP78
    Uma Kant Misra
    Department of Pathology, Duke University, Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 281:13694-707. 2006
    ..In conclusion, alpha2M* promotes cellular proliferation of 1-LN prostate cancer cells by activating MAPK and Akt-dependent signaling, down-regulating apoptotic signaling, and activating unfolded protein response signaling...
  95. ncbi Growth suppression, altered stomatal responses, and augmented induction of heat shock proteins in cytosolic ascorbate peroxidase (Apx1)-deficient Arabidopsis plants
    Lilach Pnueli
    Department of Biology, Technion Israel Institute of Technology, Technion City, Haifa 32000, Israel
    Plant J 34:187-203. 2003
    ..characterized by suppressed growth and development, altered stomatal responses, and augmented induction of heat shock proteins during light stress...
  96. ncbi Comparison of the small heat shock proteins alphaB-crystallin, MKBP, HSP25, HSP20, and cvHSP in heart and skeletal muscle
    Nikola Golenhofen
    Institute of Anatomy and Cell Biology, University of Wurzburg, Koellikerstrasse 6, 97070, Wurzburg, Germany
    Histochem Cell Biol 122:415-25. 2004
    ..Thus sHSPs form a complex stress-response system in striated muscle tissue with some common as well as some distinct functions in different muscle types...
  97. ncbi Acetyl-L-carnitine-induced up-regulation of heat shock proteins protects cortical neurons against amyloid-beta peptide 1-42-mediated oxidative stress and neurotoxicity: implications for Alzheimer's disease
    Hafiz Mohmmad Abdul
    Department of Chemistry, Center for Membrane Sciences, University of Kentucky, Lexington, 40506, USA
    J Neurosci Res 84:398-408. 2006
    ..Addition of ALCAR to neurons also led to an elevated cellular GSH and heat shock proteins (HSPs) levels compared with untreated control cells...
  98. pmc Key features of heat shock regulatory elements
    J Amin
    Department of Biochemistry and Molecular Biology, University of Miami School of Medicine, Florida 33101
    Mol Cell Biol 8:3761-9. 1988
    ..Second, the nucleotides at the two positions immediately upstream from GAA segments played an important role in defining the competence of regulatory elements...
  99. pmc Essential role of the unfolded protein response regulator GRP78/BiP in protection from neuronal apoptosis
    M Wang
    Department of Biochemistry and Molecular Biology, USC Norris Comprehensive Cancer Center, University of Southern California Keck School of Medicine, Los Angeles, CA 90089 9176, USA
    Cell Death Differ 17:488-98. 2010
    ..Our studies uncover a novel link between GRP78 depletion and reduction in cytosolic ubiquitination and establish a novel mouse model of accelerated cerebellar degeneration with basic and clinical applications...
  100. ncbi Extensive functional overlap between sigma factors in Escherichia coli
    Joseph T Wade
    Department of Biological Chemistry and Molecular Pharmacology, Harvard University, Boston, Massachusetts 02115, USA
    Nat Struct Mol Biol 13:806-14. 2006
    ..SigmaE-regulated promoters also overlap extensively with those for sigma70. These results suggest that extensive functional overlap between sigma factors is an important phenomenon...
  101. ncbi The structure of ClpB: a molecular chaperone that rescues proteins from an aggregated state
    Sukyeong Lee
    Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Cell 115:229-40. 2003
    ..Taken together, we propose a mechanism by which an ATP-driven conformational change is coupled to a large coiled-coil motion, which is indispensable for protein disaggregation...

Research Grants74

  1. Alpha B crystallin as a novel therapeutic for SIRS and Sepsis
    Jonathan B Rothbard; Fiscal Year: 2011
    ..The ability of the small heat shock proteins to bind partially unfolded proteins and lower their concentration at sites of inflammation and consequently ..
  2. Combination drug treatment to inhibit multiple cell death pathways after TBI
    ALAN IRA FADEN; Fiscal Year: 2010
    ....
  3. Heat Shock Protein Synthesis Inhibitor Treatment of Hepatitis C Viral Infection
    SAMUEL WHEELER FRENCH; Fiscal Year: 2013
    ..We have identified the heat shock proteins (HSP)s HSP40 and HSP70 in complex with the HCV encoded protein NS5A through mass spectrometric analysis...
  4. IGFBP-5 and Hsp70 in Extracellular Matrix Homeostasis and Fibrosis
    Kristen L Veraldi; Fiscal Year: 2013
    ..involved in lGFBP-5's regulation of Hsp70 and the ECM, as well as in regulation of ECM production by heat shock proteins and transcription factors...
  5. Amelioration of cisplatin ototoxicity by transplatin
    Debashree Mukherjea; Fiscal Year: 2010
    ..of NADPH oxidase subunlts (such as N0X3, Rac1, p22phox and p67phox), stress proteins (such as TRPV1, KIM-1, heat shock proteins and heat shock factor) and apoptotic proteins will also be assessed...
  6. Heat Shock Effects on Human Mesenchymal Stem Cell Differentiation in Hydrogel
    Sihong Wang; Fiscal Year: 2010
    ..In addition, the upregulation of heat shock proteins (HSPs) and their important roles in embryonic development have been widely recognized...
  7. MECHANISM OF DRUG TRANSPORT IN LUNG CANCER CELLS
    Sanjay Awasthi; Fiscal Year: 2011
    ..Rlip and ral, cdc42, clathrin-adapter AP-2, POB1, epsin, grb2/nck, src, insulin, EGF-R, TGF beta, hsf-1 and heat shock proteins. These proteins are key elements of cell membrane plasticity, actin-cytoskeletal regulation and cell ..
  8. Prevention of Retinal Degeneration by Crystallins in Experimental Uveitis
    Narsing A Rao; Fiscal Year: 2011
    ..by well-recognized anti-apoptotic proteins, including 1B crystallin, heat shock protein 27 and other heat shock proteins. Significantly, 1A crystallin knockout mice with early EAU show prominent apoptosis in the retina;such ..
  9. Anti-inflammatory effects of colitis-induced changes in commensal gut microbes
    JONATHAN JAMES HANSEN; Fiscal Year: 2013
    ..models of IBD's suggest that inflammation causes intestinal bacteria to increase expression of small heat shock proteins, which in turn attenuate host inflammation...
  10. Role of Heat Shock Transcription Factor Hsf1 in Tumorigenesis
    Nahid F Mivechi; Fiscal Year: 2013
    ..DESCRIPTION (provided by applicant): A hallmark in the pathogenesis of cancer is the increased expression of heat shock proteins (Hsps) and other molecular chaperones...
  11. Novel Chaperone Mechanism for Platelet Disorder
    Zihai Li; Fiscal Year: 2010
    ..Successful execution of this study may lead to new understanding of the causes of BSS and potential novel treatments of BSS and other platelet disorders. ..
  12. CSHL 2010 Conference on Molecular Genetics and Bacteria & Phages
    David J Stewart; Fiscal Year: 2010
    ..This international conference will provide a forum for scientists working on related topics to share their latest discoveries and will bring together the leading experts in the field. ..
  13. The Impact of Heat Shock Protein Expression on Inflammation and Insulin Action
    Andrea L Hevener; Fiscal Year: 2013
    ..defense against inflammatory insult includes the rapid synthesis of a family of chaperone proteins known as heat shock proteins (HSPs) through the induction of heat shock transcritpion factor (HSF)-1...
  14. The Role of FKBP10 in Recessive Osteogenesis Imperfecta
    Caressa Lietman; Fiscal Year: 2013
    ..The National Institute of Dental and Craniofacial Research is the recipient organization of this fellowship because OI and Bruck syndrome are characterized by craniofacial phenotypes. ..
  15. 2012 CSHL Bacteria &Phages Conference
    David J Stewart; Fiscal Year: 2012
    ..This international conference will provide a forum for scientists working on related topics to share their latest discoveries and will bring together the leading experts in the field. ..
  16. Targeting Tight Junctions To Treat Mucositis
    FREDERICK GARY TOBACK; Fiscal Year: 2010
    ..This project is aimed at learning how this protein fragment exerts its biological effects because when it is given to mice or hamsters with experimental oral mucositis, it protects against and speeds recovery from injury. ..
  17. Liver Cell Membrane Protein-Expression and Function
    Allan W Wolkoff; Fiscal Year: 2012
    ..Ultimately, the studies performed in this Program will lead to fundamental insights that should be important for understanding and treating or preventing various acquired and inherited disorders of the liver. ..
  18. Optimization of HDAC6 Inhibitors in the Treatment of CMT
    Ludo Van Den Bosch; Fiscal Year: 2013
    ....
  19. Bacterial Stress Responses to Intestinal Inflammation
    JONATHAN JAMES HANSEN; Fiscal Year: 2013
    ....
  20. Immunomodulatory Mechanisms of Withafarin A in Her-2 neu breast cancer
    ANNALISE ROXANNE SMITH; Fiscal Year: 2013
    ..The benefit of such a strategy would impact the frequent recurrence of metastases of dormant tumor cells after conventional chemotherapy regimens that can cause tumor relapse and therapeutic failure. ..
  21. Heat shock protein 90 antagonist-based therapy of mantle cell lymphoma
    Kapil Bhalla; Fiscal Year: 2012
    ..This strategy involves combinations of treatments with heat shock protein 90 and proteosome inhibitors designed to target protein folding and degradation in MCL cells. ..
  22. Heme Oxygenase-1 in Lung Ischemia-Reperfusion Injury
    Patty J Lee; Fiscal Year: 2012
    ....
  23. DEVELOPMENT AND MAINTENANCE OF LENS TRANSPARENCY
    JOHN IRWIN CLARK; Fiscal Year: 2013
    ..AIM 1 will optimize the function of human ?B crystallin, the archetype of all small heat shock proteins (sHSP)...
  24. Regulation of Tumor Associated Macrophages by TGF-beta
    Venkateshwar G Keshamouni; Fiscal Year: 2012
    ..However, The TME is rich in host derived molecules, including heat shock proteins, double stranded DNA from necrotic tumor cells and Hyaluronic acid that can potentially activate macrophage ..
  25. Identification of key tumor cell-released factors that induce cachexia
    Yi Ping Li; Fiscal Year: 2013
    ..In preliminary studies, we found that a number of cachectic tumor cells constitutively release specific heat shock proteins (HSPs), which appear to be critical agents in tumor-induced cachexia...
  26. Microbial regulation of intestinal gene expression through microRNA
    Sushila Dalal; Fiscal Year: 2012
    ..I have chosen to investigate whether miRNAs are involved in the microbial regulation of intestinal heat shock proteins (Hsps)...
  27. Heat Shock-Induced Apoptosis
    Shawn B Bratton; Fiscal Year: 2012
    ..Thus, it is anticipated that the work proposed herein will significantly improve our understanding of how heat shock works in the clinic and may shed light on new pathways that can be exploited therapeutically in the future. ..
  28. Development of Small Heat Shock Proteins as Therapeutic Agents in the Eye
    JONATHAN MARK PETRASH; Fiscal Year: 2010
    ..The small heat shock proteins (sHSP) proteins aA-crystallin and aB-crystallin have excellent potential as therapeutic proteins against ..
  29. The Role of Beta-Arrestins 1 and 2 in Rheumatoid Arthritis
    Hongkuan Fan; Fiscal Year: 2010
    ..abstract_text> ..
  30. Stress Proteins in Brain Cell Injury
    Rona G Giffard; Fiscal Year: 2013
    ..Overall this proposal exams a novel hypothesis: that miRNAs act as master regulators of chaperones and BCL2 family members influencing Ca2+ homeostasis, mitochondria-ER crosstalk, and outcome after cerebral ischemia. ..
  31. Gene Regulation by and of LEDGF
    Dhirendra P Singh; Fiscal Year: 2012
    ....
  32. MECHANISMS FOR FETAL HEPATIC PROGRAMMING IN THE NON-HUMAN PRIMATE (NHP)
    Jacob E Friedman; Fiscal Year: 2010
    ....
  33. Targeting stress-mediated pathways in the treatment of muscle insulin resistance
    Paige C Geiger; Fiscal Year: 2013
    ..provided by applicant): There is a critical need to understand the fundamental antioxidant properties of heat shock proteins (HSPs) in skeletal muscle and establish novel HSP therapies for preventing insulin resistance...
  34. Mitogen-activated Protein Kinases and NF-kB Activation in Vascular Smooth Muscle
    Bingbing Jiang; Fiscal Year: 2010
    ....
  35. Heat shock proteins in brain ischemia and stroke
    Midori A Yenari; Fiscal Year: 2013
    ..Work by our labs and those of our collaborators'have focused on the protective potential of heat shock proteins, namely, the highly inducible 70 kD heat shock protein (HSP70)...
  36. Alcohol, Glial Gene Expression and the Heat Shock Pathway
    Neil L Harrison; Fiscal Year: 2010
    ..We will measure the effects of alcohol on the expression of heat shock proteins (Hsps) and study the translocation of HSF1, and the interaction between HSF1 and the ARE in astrocyte ..
  37. Modulation of TLR4 and TLR9 Signaling in NEC
    David J Hackam; Fiscal Year: 2013
    ....
  38. Modulation of Immune senescence by induction of Ubiquitin-Proteasome systems
    Usha Ponnappan; Fiscal Year: 2012
    ....
  39. Calcium Handling in Cardiac Pathophysiology
    Evangelia G Kranias; Fiscal Year: 2013
    ....
  40. Novel lysine deacetylase 6 Hsp domain inhibitors against AML
    CHUNG JEN JAMES CHOU; Fiscal Year: 2013
    ..We will determine the efficacy of our lead HDAC6 inhibitor candidates against AML, performing pharmacokinetic and dynamic studies on lead inhibitor candidates, and validate the inhibitor's ability to influence biomarkers in vivo. ..
  41. Development of Extracellular Heat Shock Protein-90 as a Novel Topical Wound Heali
    Wei Li; Fiscal Year: 2013
    ..Our goal is to develop a recombinant Hsp90a peptide into a novel and more effective wound-healing agent. ..
  42. Neuroprotection Against Parkinsonian Cell Death
    Jun Chen; Fiscal Year: 2013
    ..This information will be valuable for future development of new therapeutic strategies for the treatment of Parkinson's disease and, possibly, other neurological disorders. ..
  43. Novel Hsp90 Inhibitors to Reduce Misfolded Proteins in Alzheimer's Disease
    Mary L Michaelis; Fiscal Year: 2011
    ..Successful completion of this program will advance this concept toward clinical development. ..
  44. Glycosyltransferase Golgi Retention Mechanism
    Pi Wan Cheng; Fiscal Year: 2013
    ..The results will expand our fundamental understanding of the mechanism of intracellular trafficking and Golgi retention of glycosyltransferases and could help develop therapeutic interventions for these two lung diseases in veterans. ..
  45. Aging specific gene expression in Drosophila
    JOHN GERARD TOWER; Fiscal Year: 2013
    ..b>Heat shock proteins (hsps) are induced in all species in response to heat and other stresses...
  46. Small heat shock proteins in smooth muscle plasticity
    William T Gerthoffer; Fiscal Year: 2013
    ..Discovering how this pathway can alter the function of microRNAs could lead to new anti-inflammatory drugs or combinations of drugs to treat lung diseases more effectively. ..
  47. A novel treatment, TAT-HSP70, in attenuating lung injury in sepsis induced ARDS
    MARY MELANIE LYONS; Fiscal Year: 2012
    ..These aims are consistent with NINR's mission statement of creating nurse scientists dedicated to conducting rigorous research generating new developments to improve outcomes of serious illness. ..
  48. Alexander Disease: Cellular and Molecular Mechanisms
    Albee Messing; Fiscal Year: 2012
    ..of the disorder is the Rosenthal fiber, a cytoplasmic inclusion containing intermediate filaments and small heat shock proteins that accumulates in astrocytes throughout the CMS...
  49. Experimental Therapeutics in Acute Leukemias
    William G Blum; Fiscal Year: 2010
    ..Clara Bloomfield, Dr. John Byrd, and Dr. Guido Marcucci at The Ohio State University. They will be assisted in laboratory mentoring by Dr. Denis Guttridge and Dr. James Dalton. ..
  50. Mechanism of Heat Shock Protein Induction by Glutamine
    Paul E Wischmeyer; Fiscal Year: 2012
    ..abstract_text> ..
  51. Mechanisms of Human Dermal Fibroblast Migration
    Wei Li; Fiscal Year: 2013
    ....
  52. Gut micro biota in patients with multiple sclerosis
    Howard L Weiner; Fiscal Year: 2012
    ..measured by antigen arrays and other immune measures in the blood of MS patients (oxysterols, osteopontin, heat shock proteins) and the gut microbiome? In summary, we believe that the investigation of the gut microbiome in MS fits ..
  53. Functional consequences of HSPB1 mutations that result in motor neuron disease
    Stephen J Kolb; Fiscal Year: 2013
    ..Ultimately, this project will lead to the identification of novel targets for the treatment of this devastating class of nervous system disease. ..
  54. Therapeutic vaccination against genital HPV infection
    Yung Nien Chang; Fiscal Year: 2013
    ..These preclinical studies will drive future Papivax-driven clinical trials of therapeutic vaccines to eliminate persistent HPV infections. ..
  55. VEGF and Skeletal Muscle Adaptation during Chronic Overload
    KIMBERLY ANN HUEY; Fiscal Year: 2011
    ....
  56. Phase II/III Study of Arimoclomol in the Treatment of SOD1 Positive Familial?.
    Merit E Cudkowicz; Fiscal Year: 2013
    ..Mutant SOD1 reduces the activity of heat shock proteins and thereby permits the formation of protein aggregates that constitute these neuronal and astrocytic ..
  57. Repressing HIF-1: targets and mechanisms
    Nianli Sang; Fiscal Year: 2012
    ....
  58. Heat Shock Protein-Induced Protection Against Cisplatin-Induced Hair Cell Death
    TIFFANY GRAY BAKER; Fiscal Year: 2013
    ..2009). Heat shock preconditioning, which results in upregulation of heat shock proteins (Hsps), inhibits cisplatin-induced hair cell death (Cunningham and Brandon 2006)...
  59. Heat Shock Protein Therapeutics for Stroke
    Frank R Sharp; Fiscal Year: 2013
    ABSTRACT Heat shock proteins, including Hsp70, are chaperones induced by heat shock and many stresses including ischemia and assist protein folding during protein synthesis and re-folding after protein denaturation...
  60. DnaK Protein Inhibitor Antimicrobials
    Michael Sturgess; Fiscal Year: 2003
    ..abstract_text> ..
  61. The functions and mechanism of SHSP degradation in Escherichia coli
    ELLEN FRANCES VIEUX; Fiscal Year: 2011
    ....
  62. Regulation of Eye Growth and Development by the Lens
    William R Jeffery; Fiscal Year: 2012
    ..Using the blind cavefish as a model, this study is designed to provide new information about the role of the ocular lens in coordinating eye development. The results will provide insights into abnormal eye development. ..
  63. Regulation of TLR4 Signaling in Enterocytes in Necrotizing Enterocolitis
    Amin Afrazi; Fiscal Year: 2013
    ..The current proposal seeks to test whether increasing levels of Heat Shock Protein 70 can serve as a novel therapeutic approach for infants with this devastating disorder. ..
  64. The Role of HMGB1 in Acute Lung Injury-Induced Endothelial Cell Permeability
    Rachel K Wolfson; Fiscal Year: 2012
    ..This proposal aims to define the mechanism by which HMGB1 disrupts lung endothelial cell barrier function and contributes to ALI, opening the door for potential therapeutic intervention in the future. ..
  65. Use of Probiotic Conditioned Media to Protect Against Necrotizing Enterocolitis
    ERIKA CLAUD; Fiscal Year: 2009
    ..mechanisms, including (A) enhancement of intestinal barrier function, (B) induction of cytoprotective heat shock proteins and protection against ischemia-mediated oxidant injury, and (C) modulation of intestinal inflammatory ..
  66. HEAT SHOCK PROTEIN GP96 AND IMMUNITY
    Nicholas Cohen; Fiscal Year: 2003
    ..Experiments to evaluate the specificity and peptide complex-dependency of these putative alloimmune reactivities are presented as are experiments to reveal the nature of effector cells involved. ..
  67. FRACTIONATED HYPERTHERMIA AND HEAT SHOCK PROTEINS
    Gloria Li; Fiscal Year: 1999
    ..Results from this study will assist us in understanding the functions of HSF1 and CHBF, and their involvement in the dual control mechanism of heat shock gene expression. ..
  68. Heat Shock Proteins, Nitric Oxide and Oxygen Consumption in the Heart
    Govindasamy Ilangovan; Fiscal Year: 2009
    ..While HT induces the heat shock proteins (HSP), which can act as chaperones in preventing myocardial infarction, IPC is known to induce nitric oxide ..
  69. PROFILING SYNOVIAL VASCULATURE IN ARTHRITIS-PRONE RATS
    KAMAL MOUDGIL; Fiscal Year: 2005
    ..abstract_text> ..
  70. Relative Roles of HSP70 and HSP25 in the Modulation of Renal Injury
    Rajasree Sreedharan; Fiscal Year: 2010
    ..In the proposed studies the effect of endogenous heat shock proteins (HSP70 and HSP25) on cellular injury will be differentiated from the influence exerted by over expressed ..
  71. The heat shock response and cytoprotection
    Hector Wong; Fiscal Year: 2006
    ....
  72. HEAT SHOCK PROTEINS IN E COLI CELL ENVELOPE
    MARY LUCKEY; Fiscal Year: 1993
    ..Characterization of the heat shock response in Escherichia coli has allowed identification of at least twenty heat shock proteins (hsps), some of which are essential for viability at normal temperatures. About half of the hsps in E...
  73. IMMUNOLOGIC BASIS ENIVR MODULATION OF AUTOIM ARTHRITIS
    KAMAL MOUDGIL; Fiscal Year: 2001
    ....
  74. Lipids Interactions of Small Heat Shock Proteins
    Elizabeth Vierling; Fiscal Year: 2005
    ..The parent grant concerns a ubiquitous family of stress proteins, the small heat shock proteins (sHsps), that are proposed to act as molecular chaperones in stressed and diseased cells...