eye proteins

Summary

Top Publications

  1. pmc Safety and efficacy of gene transfer for Leber's congenital amaurosis
    Albert M Maguire
    Scheie Eye Institute, University of Pennsylvania, USA
    N Engl J Med 358:2240-8. 2008
  2. ncbi Pax6: a multi-level regulator of ocular development
    Ohad Shaham
    Sackler Faculty of Medicine, Department of Human Molecular Genetics and Biochemistry, Tel Aviv University, Ramat Aviv, Tel Aviv 69978, Israel
    Prog Retin Eye Res 31:351-76. 2012
  3. pmc neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas
    G Gradwohl
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Centre National de la Recherche Scientifique Institut National de la Santé et de la Recherche Médicale Université Louis Pasteur, F 67404 Illkirch, France
    Proc Natl Acad Sci U S A 97:1607-11. 2000
  4. pmc Treatment of leber congenital amaurosis due to RPE65 mutations by ocular subretinal injection of adeno-associated virus gene vector: short-term results of a phase I trial
    William W Hauswirth
    Department of Ophthalmology, University of Florida, Gainesville, FL 32610, USA
    Hum Gene Ther 19:979-90. 2008
  5. ncbi Pax6 is required for the multipotent state of retinal progenitor cells
    T Marquardt
    Max Planck Institute of Biophysical Chemistry, Department of Molecular Cell Biology, Am Fassberg 11, D 37077, Gottingen, Germany
    Cell 105:43-55. 2001
  6. ncbi TREK-1 and Best1 channels mediate fast and slow glutamate release in astrocytes upon GPCR activation
    Dong Ho Woo
    Center for Neural Science, Korea Institute of Science and Technology, Seoul, Republic of Korea
    Cell 151:25-40. 2012
  7. ncbi Reiterative use of the EGF receptor triggers differentiation of all cell types in the Drosophila eye
    M Freeman
    MRC Laboratory of Molecular Biology, Cambridge, United Kingdom
    Cell 87:651-60. 1996
  8. ncbi Differentiation of mouse embryonic stem cells into a defined neuronal lineage
    Miriam Bibel
    Friedrich Miescher Institute, CH 4058 Basel, Switzerland
    Nat Neurosci 7:1003-9. 2004
  9. ncbi Channel-mediated tonic GABA release from glia
    Soojung Lee
    Center for Neural Science, Korea Institute of Science and Technology KIST, Seoul, Korea
    Science 330:790-6. 2010
  10. ncbi Effect of gene therapy on visual function in Leber's congenital amaurosis
    James W B Bainbridge
    Institute of Ophthalmology, University College London, London, United Kingdom
    N Engl J Med 358:2231-9. 2008

Research Grants

  1. Early-onset retinal degenerations
    Samuel Jacobson; Fiscal Year: 2005
  2. PATHOGENESIS OF RETINAL DEGENERATIONS
    Samuel Jacobson; Fiscal Year: 2001
  3. Molecular Basis of Myocilin Function in the Human Eye
    W Daniel Stamer; Fiscal Year: 2010
  4. CELLULAR BIOLOGY OF THE TRABECULAR MESHWORK
    Michael P Fautsch; Fiscal Year: 2010
  5. CADHERIN REGULATION OF AQUEOUS HUMOR OUTFLOW
    W Stamer; Fiscal Year: 2004
  6. Molecular Analysis of the Human Aqueous Outflow Pathway
    Michael P Fautsch; Fiscal Year: 2010
  7. SELENIUM-INDUCED GLAUCOMA
    W Stamer; Fiscal Year: 2006
  8. CADHERIN DYNAMICS AND GLAUCOMA
    W Daniel Stamer; Fiscal Year: 2010
  9. A New Method for Retinal Imaging
    Alan Marmorstein; Fiscal Year: 2005
  10. Regulation of the Ocular Immune Response by Retinal Pigment Epithelium
    Hui Shao; Fiscal Year: 2007

Detail Information

Publications316 found, 100 shown here

  1. pmc Safety and efficacy of gene transfer for Leber's congenital amaurosis
    Albert M Maguire
    Scheie Eye Institute, University of Pennsylvania, USA
    N Engl J Med 358:2240-8. 2008
    ..Although the follow-up was very short and normal vision was not achieved, this study provides the basis for further gene therapy studies in patients with LCA...
  2. ncbi Pax6: a multi-level regulator of ocular development
    Ohad Shaham
    Sackler Faculty of Medicine, Department of Human Molecular Genetics and Biochemistry, Tel Aviv University, Ramat Aviv, Tel Aviv 69978, Israel
    Prog Retin Eye Res 31:351-76. 2012
    ..Pax6 functions at multiple levels to integrate extracellular information and execute cell-intrinsic differentiation programs that culminate in the specification and differentiation of a distinct ocular lineage...
  3. pmc neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas
    G Gradwohl
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Centre National de la Recherche Scientifique Institut National de la Santé et de la Recherche Médicale Université Louis Pasteur, F 67404 Illkirch, France
    Proc Natl Acad Sci U S A 97:1607-11. 2000
    ..Thus, ngn3 is required for the specification of a common precursor for the four pancreatic endocrine cell types...
  4. pmc Treatment of leber congenital amaurosis due to RPE65 mutations by ocular subretinal injection of adeno-associated virus gene vector: short-term results of a phase I trial
    William W Hauswirth
    Department of Ophthalmology, University of Florida, Gainesville, FL 32610, USA
    Hum Gene Ther 19:979-90. 2008
    ..99). Comparisons are drawn between the present work and two other studies of ocular gene therapy for RPE65-LCA that were carried out contemporaneously and reported...
  5. ncbi Pax6 is required for the multipotent state of retinal progenitor cells
    T Marquardt
    Max Planck Institute of Biophysical Chemistry, Department of Molecular Cell Biology, Am Fassberg 11, D 37077, Gottingen, Germany
    Cell 105:43-55. 2001
    ....
  6. ncbi TREK-1 and Best1 channels mediate fast and slow glutamate release in astrocytes upon GPCR activation
    Dong Ho Woo
    Center for Neural Science, Korea Institute of Science and Technology, Seoul, Republic of Korea
    Cell 151:25-40. 2012
    ..Our results reveal two distinct sources of astrocytic glutamate that can differentially influence neighboring neurons...
  7. ncbi Reiterative use of the EGF receptor triggers differentiation of all cell types in the Drosophila eye
    M Freeman
    MRC Laboratory of Molecular Biology, Cambridge, United Kingdom
    Cell 87:651-60. 1996
    ..These results broaden our view of eye development to include the whole ommatidium and suggest that reiterative activation of DER is critical for triggering the differentiation of all cell types...
  8. ncbi Differentiation of mouse embryonic stem cells into a defined neuronal lineage
    Miriam Bibel
    Friedrich Miescher Institute, CH 4058 Basel, Switzerland
    Nat Neurosci 7:1003-9. 2004
    ..As they do in vivo, these cells went on to generate neurons with remarkably uniform biochemical and electrophysiological characteristics...
  9. ncbi Channel-mediated tonic GABA release from glia
    Soojung Lee
    Center for Neural Science, Korea Institute of Science and Technology KIST, Seoul, Korea
    Science 330:790-6. 2010
    ..Our results identify a molecular mechanism for tonic inhibition and establish a role for interactions between glia and neurons in mediating tonic inhibition...
  10. ncbi Effect of gene therapy on visual function in Leber's congenital amaurosis
    James W B Bainbridge
    Institute of Ophthalmology, University College London, London, United Kingdom
    N Engl J Med 358:2231-9. 2008
    ..These findings provide support for further clinical studies of this experimental approach in other patients with mutant RPE65. (ClinicalTrials.gov number, NCT00643747 [ClinicalTrials.gov].)...
  11. ncbi Nrl is required for rod photoreceptor development
    A J Mears
    Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, Michigan 48105, USA
    Nat Genet 29:447-52. 2001
    ..On the basis of these findings, we postulate that Nrl acts as a 'molecular switch' during rod-cell development by directly modulating rod-specific genes while simultaneously inhibiting the S-cone pathway through the activation of Nr2e3...
  12. ncbi The role of Pax-6 in eye and nasal development
    J C Grindley
    Developmental Genetics Section, Western General Hospital, Edinburgh, UK
    Development 121:1433-42. 1995
    ....
  13. pmc Gene therapy rescues photoreceptor blindness in dogs and paves the way for treating human X-linked retinitis pigmentosa
    William A Beltran
    Section of Ophthalmology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 109:2132-7. 2012
    ..Efficacy of gene therapy in these large animal models of X-linked retinitis pigmentosa provides a path for translation to human treatment...
  14. ncbi Concise review: Pax6 transcription factor contributes to both embryonic and adult neurogenesis as a multifunctional regulator
    Noriko Osumi
    Division of Developmental Neuroscience, Center for Translational and Advanced Animal Research, Tohoku University School of Medicine, 2 1, Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    Stem Cells 26:1663-72. 2008
    ..Pax6 is a multifunctional player regulating proliferation and differentiation through the control of expression of different downstream molecules in a highly context-dependent manner...
  15. ncbi CRY, a Drosophila clock and light-regulated cryptochrome, is a major contributor to circadian rhythm resetting and photosensitivity
    P Emery
    Department of Biology, Brandeis University Waltham, Massachusetts 02454, USA
    Cell 95:669-79. 1998
    ..Taken together with the data in the accompanying paper, we propose that CRY is a major Drosophila photoreceptor dedicated to the resetting of circadian rhythms...
  16. ncbi Proteases, proteolysis and inflammatory molecules in the tears of people with keratoconus
    Sivaraman Arumugam Balasubramanian
    Brien Holden Vision Institute, Sydney, NSW, Australia
    Acta Ophthalmol 90:e303-9. 2012
    ..To investigate the expression of proteases, proteolytic activity and cytokines in the tear film of people with keratoconus...
  17. pmc Current concepts on primary open-angle glaucoma genetics: a contribution to disease pathophysiology and future treatment
    M Gemenetzi
    Southampton Eye Unit, Southampton General Hospital, Southampton, UK
    Eye (Lond) 26:355-69. 2012
    ..It emphasizes the correlation of recent achievements in genetics with glaucoma pathophysiology, glaucoma treatment perspectives, and the possibility of future prevention of irreversible visual loss caused by the disease...
  18. pmc Inhibition of Eyes Absent Homolog 4 expression induces malignant peripheral nerve sheath tumor necrosis
    S J Miller
    Department of Pediatrics, Division of Experimental Hematology and Cancer Biology, Cincinnati Children s Hospital Research Foundation, University of Cincinnati College of Medicine, Cincinnati, OH 45229 3039, USA
    Oncogene 29:368-79. 2010
    ..Our findings identify a role of EYA4 and possibly interacting SIX and DACH proteins in MPNSTs and suggest the EYA4 pathway as a rational therapeutic target...
  19. pmc Norrin, frizzled-4, and Lrp5 signaling in endothelial cells controls a genetic program for retinal vascularization
    Xin Ye
    Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Cell 139:285-98. 2009
    ....
  20. ncbi A functional polymorphism at 3'UTR of the PAX6 gene may confer risk for extreme myopia in the Chinese
    Chung Ling Liang
    Bright Eyes Clinic, Kaohsiung, Taiwan
    Invest Ophthalmol Vis Sci 52:3500-5. 2011
    ..Conflicting results have been reported regarding the association between PAX6 polymorphism and myopia. This case-control study and functional assay were conducted to identified a functional risk polymorphism for myopia...
  21. pmc In-frame deletion in a novel centrosomal/ciliary protein CEP290/NPHP6 perturbs its interaction with RPGR and results in early-onset retinal degeneration in the rd16 mouse
    Bo Chang
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    Hum Mol Genet 15:1847-57. 2006
    ..Our findings suggest a critical function for CEP290 in ciliary transport and provide insights into the mechanism of early-onset photoreceptor degeneration...
  22. ncbi Effective gene therapy with nonintegrating lentiviral vectors
    Rafael J Yáñez-Muñoz
    Molecular Immunology Unit, Institute of Child Health, University College London, 30 Guilford Street, London WC1N 1EH, UK
    Nat Med 12:348-53. 2006
    ..For therapeutic application to postmitotic tissues, this system substantially reduces the risk of insertional mutagenesis...
  23. ncbi The role of Pax6 in forebrain development
    Petrina A Georgala
    Genes and Development Group, Centre for Integrative Physiology, University of Edinburgh, Edinburgh EH89XD, United Kingdom
    Dev Neurobiol 71:690-709. 2011
    ..Such studies should also help generate an increasingly coherent understanding of how this pleiotropic transcription factor becomes involved in so many facets of neural development...
  24. ncbi Leber congenital amaurosis: genes, proteins and disease mechanisms
    Anneke I den Hollander
    Department of Human Genetics and Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Prog Retin Eye Res 27:391-419. 2008
    ....
  25. ncbi Crumbs, the Drosophila homologue of human CRB1/RP12, is essential for photoreceptor morphogenesis
    Milena Pellikka
    Department of Zoology, University of Toronto, Toronto, Ontario M5S 3G5, Canada
    Nature 416:143-9. 2002
    ..Defects in such scaffolds may contribute to human CRB1-related retinal dystrophies...
  26. pmc Pax6 activity in the lens primordium is required for lens formation and for correct placement of a single retina in the eye
    R Ashery-Padan
    Max Planck Institute of Biophysical Chemistry, Department of Molecular Cell Biology, Goettingen D 37077, Germany
    Genes Dev 14:2701-11. 2000
    ....
  27. pmc Primary open-angle glaucoma genes
    J H Fingert
    Department of Ophthalmology and Visual Sciences, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    Eye (Lond) 25:587-95. 2011
    ..Each of these different approaches to study glaucoma genetics is providing new insights into the pathogenesis of POAG...
  28. ncbi RIBEYE, a component of synaptic ribbons: a protein's journey through evolution provides insight into synaptic ribbon function
    F Schmitz
    Howard Hughes Medical Institute, Center for Basic Neuroscience, Department of Molecular Genetics, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Neuron 28:857-72. 2000
    ..Our results define a unique component of synaptic ribbons and suggest that RIBEYE evolved in vertebrates under utilization of a preexisting protein to build a unique scaffold for a specialized synapse...
  29. ncbi The genetics of primary open-angle glaucoma: a review
    R Rand Allingham
    Duke University Eye Center, Duke University, Durham, NC 27710, USA
    Exp Eye Res 88:837-44. 2009
    ..This review examines what is currently known about the underlying genetic structure, what remains to be learned, and how this may affect our medical management of this major blinding disease...
  30. ncbi VSX1: a gene for posterior polymorphous dystrophy and keratoconus
    Elise Heon
    Cellular and Molecular Division, Toronto Western Research Institute, Toronto Western Hospital, 399 Bathurst Street, Toronto, Ontario, Canada M5T 2S8
    Hum Mol Genet 11:1029-36. 2002
    ..These data define the molecular basis of two important corneal dystrophies and reveal the importance of the CVC domain in the human retina...
  31. ncbi Pax6 is crucial for β-cell function, insulin biosynthesis, and glucose-induced insulin secretion
    Yvan Gosmain
    Diabetes Unit, Division of Endocrinology, Diabetes, and Nutrition, University Hospital, University of Geneva Medical School, 1211 Geneva 14, Switzerland
    Mol Endocrinol 26:696-709. 2012
    ..We provide further evidence that Pax6 represents a key element of mature β-cell function...
  32. ncbi The role of Pax6 in regulating the orientation and mode of cell division of progenitors in the mouse cerebral cortex
    Maki Asami
    Institute for Stem Cell Research, Helmholtz Zentrum Munchen German Research Center for Environmental Health, Ingolstadter Landstr 1, 85764 Neuherberg Munich, Germany
    Development 138:5067-78. 2011
    ..Taken together, our work reveals several direct effects that the transcription factor Pax6 has on the machinery that mediates the orientation and mode of cell division...
  33. pmc Exaggerated eye growth in IRBP-deficient mice in early development
    Jeffrey Wisard
    Department of Ophthalmology, Emory University, Atlanta, Georgia 30322, USA
    Invest Ophthalmol Vis Sci 52:5804-11. 2011
    ..Because interphotoreceptor retinoid-binding protein (IRBP) is expressed before being needed in its presumptive role in the visual cycle, we tested whether it controls eye growth during development...
  34. pmc CRB1 mutations in inherited retinal dystrophies
    Kinga Bujakowska
    INSERM, U968, Paris, France
    Hum Mutat 33:306-15. 2012
    ..This meta-analysis suggests that the differential phenotype of patients with CRB1 mutations is due to additional modifying factors rather than particular mutant allele combination...
  35. pmc Relative roles of the different Pax6 domains for pancreatic alpha cell development
    Petra Dames
    Ludwig Maximilians Universitat, Klinikum Grosshadern, Medizinische Klinik, Munchen, Germany
    BMC Dev Biol 10:39. 2010
    ..We ask the question of how the differentiation of pancreatic endocrine cells, in particular that of alpha-cells, is affected by selective inactivation of either one of the three major domains of Pax6...
  36. ncbi Drosophila CRY is a deep brain circadian photoreceptor
    P Emery
    Department of Biology, National Science Foundation Center for Biological Timing, Waltham, Massachusetts 02454, USA
    Neuron 26:493-504. 2000
    ..These brain neurons therefore contain an identified deep brain photoreceptor, as well as the other circadian elements: a central pace-maker and a behavioral output system...
  37. pmc The level of the transcription factor Pax6 is essential for controlling the balance between neural stem cell self-renewal and neurogenesis
    Stephen N Sansom
    Gurdon Institute and Department of Biochemistry, University of Cambridge, Cambridge, UK
    PLoS Genet 5:e1000511. 2009
    ....
  38. pmc Tubby and tubby-like protein 1 are new MerTK ligands for phagocytosis
    Nora B Caberoy
    Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    EMBO J 29:3898-910. 2010
    ..PPBD was mapped to the highly conserved 54 amino acids at the C-terminal end of tubby and Tulp1. These data suggest that tubby and Tulp1 are novel bridging molecules to facilitate phagocytosis through MerTK...
  39. ncbi Six3, a murine homologue of the sine oculis gene, demarcates the most anterior border of the developing neural plate and is expressed during eye development
    G Oliver
    Department of Molecular Cell Biology, Max Planck Institute of Biophysical Chemistry, Gottingen, Germany
    Development 121:4045-55. 1995
    ..This region shares a homology with the distal region of mouse chromosome 17 where Six3 has been mapped...
  40. pmc Genetic analysis of Indian families with autosomal recessive retinitis pigmentosa by homozygosity screening
    Hardeep Pal Singh
    Kallam Anji Reddy Molecular Genetics Laboratory, Champalimaud Translational Centre for Eye Research, Hyderabad Eye Research Foundation, Hyderabad, India
    Invest Ophthalmol Vis Sci 50:4065-71. 2009
    ..To identify the disease-causing genes in families with autosomal recessive RP (ARRP)...
  41. ncbi Circulating pigment epithelium-derived factor levels are associated with insulin resistance and decrease after weight loss
    Monica Sabater
    Department of Diabetes, Endocrinology, and Nutrition, Institut d Investigació Biomédica de Girona, Instituto de Salud Carlos III, Girona, Spain
    J Clin Endocrinol Metab 95:4720-8. 2010
    ..We aimed to study circulating pigment epithelium-derived factor (PEDF) in vivo in association with insulin resistance and in vitro in human adipocytes...
  42. pmc PAX6 haplotypes are associated with high myopia in Han chinese
    Bo Jiang
    Department of Ophthalmology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
    PLoS ONE 6:e19587. 2011
    ..Linkage of myopia to the PAX6 region on chromosome 11p13 was shown in several studies, but the results for association between myopia and PAX6 were inconsistent so far...
  43. pmc Constitutive overexpression of pigment epithelium-derived factor inhibition of ocular melanoma growth and metastasis
    Hua Yang
    Department of Ophthalmology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Invest Ophthalmol Vis Sci 51:28-34. 2010
    ..This study investigates whether constitutive overexpression of PEDF inhibits the growth and hepatic micrometastasis of ocular melanoma...
  44. pmc VSX1 gene analysis in keratoconus
    Mukesh Tanwar
    Laboratory for Molecular Reproduction and Genetics, Department of Anatomy, Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India
    Mol Vis 16:2395-401. 2010
    ..To screen the visual system homeobox 1 (VSX1) gene in keratoconus patients...
  45. pmc Crystal structure of the human Pax6 paired domain-DNA complex reveals specific roles for the linker region and carboxy-terminal subdomain in DNA binding
    H E Xu
    Department of Biology and Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139 USA
    Genes Dev 13:1263-75. 1999
    ....
  46. ncbi Two independent and interactive DNA-binding subdomains of the Pax6 paired domain are regulated by alternative splicing
    J A Epstein
    Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts
    Genes Dev 8:2022-34. 1994
    ..The functional nonequivalence of the two Pax6 proteins is underscored by a T-->C mutation at position -3 of the alternative splice acceptor site that changes the ratio of the two isoforms and causes a distinct human ocular syndrome...
  47. pmc Rpe65 is the retinoid isomerase in bovine retinal pigment epithelium
    Minghao Jin
    Jules Stein Eye Institute, UCLA School of Medicine, Los Angeles, California 90095, USA
    Cell 122:449-59. 2005
    ..Rpe65 with the Leber-associated C330Y and Y368H substitutions had no isomerase activity. Identification of Rpe65 as the isomerase explains the phenotypes in rpe65-/- knockout mice and in humans with Leber congenital amaurosis...
  48. pmc Pax6 is essential for lens fiber cell differentiation
    Ohad Shaham
    Department of Human Molecular Genetics and Biochemistry, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Development 136:2567-78. 2009
    ..This study reveals that Pax6 is pivotal for initiation of the lens fiber differentiation program in the mammalian eye...
  49. ncbi Leber congenital amaurosis - a model for efficient genetic testing of heterogeneous disorders: LXIV Edward Jackson Memorial Lecture
    Edwin M Stone
    Department of Ophthalmology, The University of Iowa College of Medicine, Carver Family Center for Macular Degeneration, Iowa City, IA 52242, USA
    Am J Ophthalmol 144:791-811. 2007
    ....
  50. ncbi Pax-6 expression and activity are induced in the reepithelializing cornea and control activity of the transcriptional promoter for matrix metalloproteinase gelatinase B
    J M Sivak
    Vision Research Laboratories of the New England Eye Center, Department of Ophthalmology, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    Dev Biol 222:41-54. 2000
    ..These data suggest a mechanism by which Pax-6 may direct gelB expression in an eye-specific manner...
  51. ncbi The transcription factor Pax6 regulates survival of dopaminergic olfactory bulb neurons via crystallin αA
    Jovica Ninkovic
    Helmholtz Zentrum Munchen, Institute of Stem Cell Research, Ingolstädter Landstraße 1, D 85764 Neuherberg, Germany
    Neuron 68:682-94. 2010
    ..Strikingly, Pax6 utilizes different DNA-binding domains for its well-known role in fate specification and this role of regulating the survival of specific neuronal subtypes in the mature, healthy brain...
  52. ncbi Characterization of PEDF: a multi-functional serpin family protein
    S Filleur
    Department of Urology, Texas Tech University Health Sciences Center, 3601 4th Street, MS 6591, Lubbock, Texas 79430 6591, USA
    J Cell Biochem 106:769-75. 2009
    ....
  53. pmc Expression of cone-photoreceptor-specific antigens in a cell line derived from retinal tumors in transgenic mice
    Elaine Tan
    Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    Invest Ophthalmol Vis Sci 45:764-8. 2004
    ..To examine an immortalized mouse retinal cell line (661W) for markers characteristic of photoreceptor cells and validate its photoreceptor origin...
  54. pmc Pax6 is a human neuroectoderm cell fate determinant
    Xiaoqing Zhang
    Waisman Center and the WiCell Institute, Madison, WI 53705, USA
    Cell Stem Cell 7:90-100. 2010
    ....
  55. pmc Reduction of ER stress via a chemical chaperone prevents disease phenotypes in a mouse model of primary open angle glaucoma
    Gulab S Zode
    Howard Hughes Medical Institute, Department of Pediatrics, College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA
    J Clin Invest 121:3542-53. 2011
    ..These results demonstrate that ER stress is linked to the pathogenesis of POAG and may be a target for treatment in human patients...
  56. ncbi A point mutation of the rhodopsin gene in one form of retinitis pigmentosa
    T P Dryja
    Howe Laboratory of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston 02114
    Nature 343:364-6. 1990
    ....
  57. ncbi A human homologue of the Drosophila eyes absent gene underlies branchio-oto-renal (BOR) syndrome and identifies a novel gene family
    S Abdelhak
    Unite de Genetique Moleculaire Humaine, URA CNRS 1968, Institut Pasteur, Paris, France
    Nat Genet 15:157-64. 1997
    ..In the developing kidney, the expression pattern is indicative of a role for Eya1 in the metanephric cells surrounding the 'just-divided' ureteric branches...
  58. ncbi The Crumbs complex: from epithelial-cell polarity to retinal degeneration
    Natalia A Bulgakova
    Max Planck Institute for Molecular Cell Biology and Genetics, Pfotenhauerstr 108, Dresden, Germany
    J Cell Sci 122:2587-96. 2009
    ..In addition, we discuss recent results that suggest its participation in various human diseases, including blindness and tumour formation...
  59. pmc Overexpression of pigment epithelium-derived factor decreases angiogenesis and inhibits the growth of human malignant melanoma cells in vivo
    Riichiro Abe
    Department of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Am J Pathol 164:1225-32. 2004
    ..PEDF therefore might be a promising novel therapeutic agent for treatment of patients with melanoma...
  60. ncbi Identification of a gene that causes primary open angle glaucoma
    E M Stone
    Department of Ophthalmology, University of Iowa College of Medicine, Iowa City, IA 52242, USA
    Science 275:668-70. 1997
    ..One of these mutations was also found in a control individual (0.2 percent). Identification of these mutations will aid in early diagnosis, which is essential for optimal application of existing therapies...
  61. ncbi Proinflammatory cytokines and angiogenic and anti-angiogenic factors in vitreous of patients with proliferative diabetic retinopathy and eales' disease
    Ponnalagu Murugeswari
    Department of Immunology, Dr G Venkataswamy Eye Research Institute, Aravind Medical Research Foundation, Tamilnadu, India
    Retina 28:817-24. 2008
    ....
  62. ncbi Clinical and molecular aspects of aniridia
    H Kokotas
    Department of Genetics, Institute of Child Health, Aghia Sophia Children s Hospital, Athens, Greece
    Clin Genet 77:409-20. 2010
    ..Here we review the data regarding the mechanisms and the mutations that relate to aniridia...
  63. ncbi Pigment epithelium-derived factor (PEDF) is an endogenous antiinflammatory factor
    Sarah X Zhang
    Department of Medicine Endocrinology, Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA
    FASEB J 20:323-5. 2006
    ..These findings suggest that PEDF is a novel endogenous anti-inflammatory factor in the eye. The decrease of ocular PEDF levels may contribute to inflammation and vascular leakage in DR...
  64. ncbi Mutations at the PAX6 locus are found in heterogeneous anterior segment malformations including Peters' anomaly
    I M Hanson
    MRC Human Genetics Unit, Western General Hospital, Edinburgh, UK
    Nat Genet 6:168-73. 1994
    ..We therefore propose that a variety of anterior segment anomalies may be associated with PAX6 mutations...
  65. ncbi Mice lacking the homeodomain transcription factor Nkx2.2 have diabetes due to arrested differentiation of pancreatic beta cells
    L Sussel
    Nina Ireland Laboratory of Developmental Neurobiology, Department of Psychiatry, University of California, San Francisco, CA 94143, USA
    Development 125:2213-21. 1998
    ..1. We propose that Nkx2.2 is required for the final differentiation of pancreatic beta cells, and in its absence, beta cells are trapped in an incompletely differentiated state...
  66. ncbi Pigment epithelium-derived factor: a potent inhibitor of angiogenesis
    D W Dawson
    Department of Microbiology Immunology, Department of Pathology, Robert H Lurie Comprehensive Cancer Center, Northwestern University Medical School, Chicago, IL 60611, USA
    Science 285:245-8. 1999
    ..These results suggest that PEDF may be of therapeutic use, especially in retinopathies where pathological neovascularization compromises vision and leads to blindness...
  67. ncbi Pax6 is required for making specific subpopulations of granule and periglomerular neurons in the olfactory bulb
    Minoree Kohwi
    Department of Neurological Surgery, Program in Developmental and Stem Cell Biology, University of California, San Francisco, California 94143, USA
    J Neurosci 25:6997-7003. 2005
    ..Our data show that SVZ neuroblasts are heterogeneous and that Pax6 is required in a cell-autonomous manner for the production of cells in the dopaminergic lineage...
  68. pmc Rhythm defects caused by newly engineered null mutations in Drosophila's cryptochrome gene
    Eva Dolezelova
    Department of Biology, Brandeis University, Waltham, Massachusetts 02454, USA
    Genetics 177:329-45. 2007
    ..Because some norpAP24 cry0 individuals can resynchronize to novel photic regimes, an as-yet undetermined light-input route exists in Drosophila...
  69. ncbi Characterization of the vitreous proteome in diabetes without diabetic retinopathy and diabetes with proliferative diabetic retinopathy
    Ben Bo Gao
    Research Division, Beetham Eye Institute, Joslin Diabetes Center, One Joslin Place, Boston, Massachusetts 02215, USA
    J Proteome Res 7:2516-25. 2008
    ..These data provide an in depth analysis of the human vitreous proteome and reveal protein alterations that are associated with PDR...
  70. ncbi Neuronal fate determinants of adult olfactory bulb neurogenesis
    Michael A Hack
    GSF National Research Center for Environment and Health, Institute for Stem Cell Research, Ingolstadter Landstr 1, D 85764 Neuherberg, Germany
    Nat Neurosci 8:865-72. 2005
    ..Together, these data explain both extrinsic and intrinsic mechanisms controlling neuronal identity in adult neurogenesis...
  71. ncbi Pax6 overexpression suppresses cell proliferation and retards the cell cycle in corneal epithelial cells
    Jie Ouyang
    Bascom Palmer Eye Institute, Miller School of Medicine, University of Miami, FL 33136, USA, and Department of Ophthalmology, Veterans General Hospital, Taichung, Taiwan
    Invest Ophthalmol Vis Sci 47:2397-407. 2006
    ..Pax6 continues to be expressed in the ocular surface epithelia of the postnatal eye. The goal of this study was to investigate a possible role for Pax6 in controlling dynamics of the ocular surface epithelia...
  72. pmc AKAP2 anchors PKA with aquaporin-0 to support ocular lens transparency
    Matthew G Gold
    Department of Pharmacology, Howard Hughes Medical Institute, University of Washington School of Medicine, Seattle, WA, USA
    EMBO Mol Med 4:15-26. 2012
    ..Thus, anchored PKA modulation of AQP0 is a homeostatic mechanism that must be physically intact to preserve lens transparency...
  73. pmc DNaseI hypersensitivity and ultraconservation reveal novel, interdependent long-range enhancers at the complex Pax6 cis-regulatory region
    David J McBride
    Medical Research Council Human Genetics Unit, Medical Research Council Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, United Kingdom
    PLoS ONE 6:e28616. 2011
    ....
  74. pmc 3T3 cell lines stably expressing Pax6 or Pax6(5a)--a new tool used for identification of common and isoform specific target genes
    Yury Kiselev
    Research Group of Pharmacology, Department of Pharmacy, University of Tromsø, Tromsø, Norway
    PLoS ONE 7:e31915. 2012
    ..Furthermore, a change in morphology of the stably transfected Pax6 and Pax6(5a) cells was observed, and the Pax6 expressing cells were shown to have increased proliferation and migration capacities...
  75. ncbi Levels of lactoferrin, secretory IgA and serum albumin in the tear film of people with keratoconus
    Sivaraman Arumugam Balasubramanian
    Brien Holden Vision Institute, Sydney, NSW 2052, Australia
    Exp Eye Res 96:132-7. 2012
    ..05). The tears of keratoconus subjects appear to have an altered protein profile, and one that might change with the severity of the disease. These findings may lead the way to understanding or monitoring disease progression...
  76. pmc Cerulean cataract mapped to 12q13 and associated with a novel initiation codon mutation in MIP
    Xueshan Xiao
    State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat Sen University, Guangzhou, China
    Mol Vis 17:2049-55. 2011
    ..To identify the genetic defect in a large Chinese family with autosomal dominant cerulean cataract...
  77. pmc Pigment epithelium-derived factor regulates lipid metabolism via adipose triglyceride lipase
    Melissa L Borg
    Biology of Lipid Metabolism Laboratory, Department of Physiology, Monash University, Clayton, Victoria, Australia
    Diabetes 60:1458-66. 2011
    ..We used ATGL(-/-) mice to determine the role of PEDF in regulating lipid and glucose metabolism...
  78. pmc Normal ventral telencephalic expression of Pax6 is required for normal development of thalamocortical axons in embryonic mice
    T Ian Simpson
    Genes and Development Group, Centre for Integrative Physiology, University of Edinburgh, Hugh Robson Building, George Square, Edinburgh, EH8 9XD, UK
    Neural Dev 4:19. 2009
    ..Its functions in these cells are unknown...
  79. ncbi Tear analysis in ocular surface diseases
    Lei Zhou
    Singapore Eye Research Institute, Singapore
    Prog Retin Eye Res 31:527-50. 2012
    ....
  80. pmc Human retinal pigment epithelium cells as functional models for the RPE in vivo
    Zsolt Ablonczy
    Department of Ophthalmology, Medical University of South Carolina, SEI Room 518E, 167 Ashley Avenue, Charleston, SC 29425, USA
    Invest Ophthalmol Vis Sci 52:8614-20. 2011
    ..To compare their utility as RPE models, their morphologic and functional characteristics were analyzed...
  81. pmc Mutational screening of VSX1, SPARC, SOD1, LOX, and TIMP3 in keratoconus
    Patrizia De Bonis
    Unità di Genetica Medica, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy
    Mol Vis 17:2482-94. 2011
    ....
  82. ncbi Neuroprotection in diabetic retinopathy
    Cristina Hernandez
    CIBERDEM and Diabetes and Metabolism Research Unit, Vall Hebron Institut de Recerca, Universitat Autonoma de Barcelona, Spain
    Curr Diab Rep 12:329-37. 2012
    ..In this review we will focus on neurotrophic factors already synthesized by the retina in physiological conditions as a new therapy strategy for neuroprotection...
  83. pmc The Zw5 protein, a component of the scs chromatin domain boundary, is able to block enhancer-promoter interaction
    M Gaszner
    Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544 USA
    Genes Dev 13:2098-107. 1999
    ..We show that SBP is encoded by the zeste-white 5 gene and that mutations in zeste-white 5 reduce the enhancer-blocking activity of the multimerized oligonucleotides...
  84. ncbi The cataract-inducing S50P mutation in Cx50 dominantly alters the channel gating of wild-type lens connexins
    Adam M DeRosa
    Department of Physiology and Biophysics and the Graduate Program in Genetics, State University of New York, Stony Brook, NY 11794, USA
    J Cell Sci 120:4107-16. 2007
    ..Additionally, mixed channels displayed significantly altered gating properties, a phenomenon that may contribute to the cataract that is associated with this mutation...
  85. pmc Pigment epithelium-derived factor inhibits neointimal hyperplasia after vascular injury by blocking NADPH oxidase-mediated reactive oxygen species generation
    Kazuo Nakamura
    Department of Medicine, Division of Cardio Vascular Medicine, Kurume University School of Medicine, 67 Asahi Machi, Kurume 830 0011, Japan
    Am J Pathol 170:2159-70. 2007
    ..Our present study suggests that substitution of PEDF may be a novel therapeutic strategy for restenosis after balloon angioplasty...
  86. pmc A dominant mutation in RPE65 identified by whole-exome sequencing causes retinitis pigmentosa with choroidal involvement
    Sara J Bowne
    Human Genetics Center, The University of Texas Health Science Center, Houston, TX, USA
    Eur J Hum Genet 19:1074-81. 2011
    ..Gene therapy for LCA patients with RPE65 mutations has shown great promise, raising the possibility of related therapies for dominant-acting mutations in this gene...
  87. ncbi Composition and function of the Crumbs protein complex in the mammalian retina
    Ilse Gosens
    Department of Human Genetics and Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Geert Grooteplein zuid 10, PO Box 9101, 6500 HB, Nijmegen, The Netherlands
    Exp Eye Res 86:713-26. 2008
    ....
  88. ncbi Pigment epithelium-derived factor suppresses ischemia-induced retinal neovascularization and VEGF-induced migration and growth
    Elia J Duh
    Department of Ophthalmology, Johns Hopkins University School of Medicine, Maumenee 809, 600 N Wolfe Street, Baltimore, MD 21287, USA
    Invest Ophthalmol Vis Sci 43:821-9. 2002
    ....
  89. pmc Anti-tumor effect of adenovirus-mediated gene transfer of pigment epithelium-derived factor on mouse B16-F10 melanoma
    Li Ping Yang
    State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Clinical Medicine School, Sichuan University, Chengdu, Sichuan, PR China
    J Exp Clin Cancer Res 28:75. 2009
    ..As a potent inhibitor of tumor angiogenesis, pigment epithelium-derived factor (PEDF) has recently been studied and used as an anticancer agent in several tumor models...
  90. pmc Dual transcriptional activities of SIX proteins define their roles in normal and ectopic eye development
    Abigail M Anderson
    Department of Biology, Indiana University, Bloomington, IN 47405, USA
    Development 139:991-1000. 2012
    ..This model of repression-mediated induction of developmental programs could have implications beyond the eye and might be applicable to other systems...
  91. ncbi In vitro and in vivo biological activity of PEDF against a range of tumors
    Matthew L Broadhead
    University of Melbourne, St Vincent s Hospital, Department of Orthopaedics and Surgery, L3, Daly Wing, 35 Victoria Pde, Fitzroy 3065, Vic, Australia
    Expert Opin Ther Targets 13:1429-38. 2009
    ..These direct and indirect effects of PEDF have been examined in vitro and in vivo for a range of malignancies...
  92. pmc Protective effect of perindopril on diabetic retinopathy is associated with decreased vascular endothelial growth factor-to-pigment epithelium-derived factor ratio: involvement of a mitochondria-reactive oxygen species pathway
    Zhi Zheng
    Department of Ophthalmology, First People s Hospital of Shanghai, Shanghai Jiaotong University, Shanghai, China
    Diabetes 58:954-64. 2009
    ....
  93. ncbi The ratio of VEGF/PEDF expression in bone marrow mesenchymal stem cells regulates neovascularization
    Wei Fan
    Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove Campus, Brisbane QLD 4059, Australia
    Differentiation 81:181-91. 2011
    ....
  94. ncbi Pax6, Tbr2, and Tbr1 are expressed sequentially by radial glia, intermediate progenitor cells, and postmitotic neurons in developing neocortex
    Chris Englund
    Department of Pathology, University of Washington, Seattle, Washington 98195 7470, USA
    J Neurosci 25:247-51. 2005
    ....
  95. pmc Identification of the antivasopermeability effect of pigment epithelium-derived factor and its active site
    Hua Liu
    Wilmer Ophthalmological Institute, Johns Hopkins Hospital, Baltimore, MD 21287 8984, USA
    Proc Natl Acad Sci U S A 101:6605-10. 2004
    ..Furthermore, PEDF may represent a superior therapeutic approach to sepsis-associated hypotension, nephrotic syndrome, and other sight-threatening and life-threatening diseases resulting from excessive vascular permeability...
  96. ncbi Pax 6: mastering eye morphogenesis and eye evolution
    W J Gehring
    Department of Cell Biology, Biozentrum, University of Basel, Klingelbergstrasse 70, 4056 Basel, Switzerland
    Trends Genet 15:371-7. 1999
    ..It is proposed that the various eye-types found in metazoa are derived from a common prototype, monophyletically, by a mechanism called intercalary evolution...
  97. pmc Identification of pax6-dependent gene regulatory networks in the mouse lens
    Louise V Wolf
    Department of Ophthalmology, Albert Einstein College of Medicine, Bronx, New York, United States of America
    PLoS ONE 4:e4159. 2009
    ..Collectively, the present studies represent an integrative genome-wide approach to identify downstream networks controlled by Pax6 that control mouse lens and forebrain development...
  98. ncbi Crumbs homolog 1 (CRB1) mutations result in a thick human retina with abnormal lamination
    Samuel G Jacobson
    Department of Ophthalmology, Scheie Eye Institute, University of Pennsylvania, Philadelphia, PA 19104, USA
    Hum Mol Genet 12:1073-8. 2003
    ..The results suggest that the CRB1 disease pathway disturbs the development of normal human retinal organization by interrupting naturally occurring apoptosis...
  99. ncbi Oa1 knock-out: new insights on the pathogenesis of ocular albinism type 1
    B Incerti
    Telethon Institute of Genetics and Medicine, San Raffaele Biomedical Science Park, Via Olgettina 58, I 20132 Milan, Italy
    Hum Mol Genet 9:2781-8. 2000
    ..Ultrastructural analysis of the RPE cells, suggests that the giant melanosomes may form by abnormal growth of single melanosomes, rather than the fusion of several, shedding light on the pathogenesis of ocular albinism...
  100. pmc Photic signaling by cryptochrome in the Drosophila circadian system
    F J Lin
    Department of Neuroscience, Howard Hughes Medical Institute, University of Pennsylvania Medical School, Philadelphia, Pennsylvania 19104, USA
    Mol Cell Biol 21:7287-94. 2001
    ..High levels of CRY block TIM ubiquitination, suggesting a mechanism by which light-driven changes in CRY could control TIM ubiquitination...
  101. ncbi Direct interaction of geminin and Six3 in eye development
    Filippo Del Bene
    Developmental Biology Programme, EMBL, Meyerhofstrasse 1, 69012 Heidelberg, Germany
    Nature 427:745-9. 2004
    ..Our data indicate that the transcription factor Six3 and the replication-initiation inhibitor geminin act antagonistically to control the balance between proliferation and differentiation during early vertebrate eye development...

Research Grants70

  1. Early-onset retinal degenerations
    Samuel Jacobson; Fiscal Year: 2005
    ....
  2. PATHOGENESIS OF RETINAL DEGENERATIONS
    Samuel Jacobson; Fiscal Year: 2001
    ..The results of this research will lead to the formulation of hypotheses about the underlying molecular events in these diseases and may evolve into recommendations for treatment paradigms in these blinding retinal degenerations. ..
  3. Molecular Basis of Myocilin Function in the Human Eye
    W Daniel Stamer; Fiscal Year: 2010
    ..abstract_text> ..
  4. CELLULAR BIOLOGY OF THE TRABECULAR MESHWORK
    Michael P Fautsch; Fiscal Year: 2010
    ..These regions will be "preferential flow" regions, and aqueous tracers should appear in these regions first. If this occurs, it would change our basic understanding of how aqueous passes through the TM (aim 5). ..
  5. CADHERIN REGULATION OF AQUEOUS HUMOR OUTFLOW
    W Stamer; Fiscal Year: 2004
    ..abstract_text> ..
  6. Molecular Analysis of the Human Aqueous Outflow Pathway
    Michael P Fautsch; Fiscal Year: 2010
    ..We will also determine gene and protein expression changes in the meshwork induced by normal and POAG aqueous humor. Develop a medium that can be used to mimic aqueous humor for trabecular meshwork cell culture. ..
  7. SELENIUM-INDUCED GLAUCOMA
    W Stamer; Fiscal Year: 2006
    ..abstract_text> ..
  8. CADHERIN DYNAMICS AND GLAUCOMA
    W Daniel Stamer; Fiscal Year: 2010
    ..Results obtained from these investigations will provide a basic understanding of the role of cadherin proteins in aqueous outflow resistance and uncover novel therapeutic targets for glaucoma therapy. ..
  9. A New Method for Retinal Imaging
    Alan Marmorstein; Fiscal Year: 2005
    ..One form of basal deposit, basal linear deposits, are more common in AMD eyes than age-matched controls. A positive outcome to this study would warrant future clinical trials. ..
  10. Regulation of the Ocular Immune Response by Retinal Pigment Epithelium
    Hui Shao; Fiscal Year: 2007
    ..The results of our studies will provide new insights into the pathogenesis of uveitis. [unreadable] [unreadable] [unreadable]..
  11. The role of costimulatory molecules in uveitis
    Hui Shao; Fiscal Year: 2011
    ..These studies should provide insights into the pathogenic mechanism leading to disease progression and help in the development of supplementary therapies for this devastating disease. ..
  12. Proteomic Analysis of Retinal Ganglion Cell Death in Glaucoma
    GULGUN TEZEL; Fiscal Year: 2010
    ..These studies are expected to provide comprehensive information about the nerve cell death process, thereby allowing new treatment possibilities for 3 million Americans suffering from glaucoma. ..
  13. LDL Modification in Diabetic Complications
    MARGO COHEN; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  14. Transgenic Rod Development and Function
    Baerbel Rohrer; Fiscal Year: 2005
    ..However, more importantly, it will provide avenues for studying gene defects at the single cell level not only in the retina, but in other systems as well. ..
  15. Molecular Phenotypes of Primary Open Angle Glaucoma
    Mary K Wirtz; Fiscal Year: 2010
    ..This study will form the basis for future studies aimed at identifying and characterizing the genes that influence POAG risk factors. ..
  16. ROD NEURODEGENERATIVE AND PROTECTIVE GENES
    Baerbel Rohrer; Fiscal Year: 2005
    ..We expect to isolate common downstream target genes that are activated both during degeneration and neuroprotection. ..
  17. Reducing Renal TGF-B in Diabetic Glomerulosclerosis
    MARGO COHEN; Fiscal Year: 2005
    ..abstract_text> ..
  18. Dissecting the Molecular Basis of Ocular Albinism type 1
    Maria Vittoria Schiaffino; Fiscal Year: 2007
    ..abstract_text> ..
  19. The Optic Nerve Head in Glaucoma
    Elaine Johnson; Fiscal Year: 2008
    ..abstract_text> ..
  20. Molecular and Cellular Mechanisms of Glaucoma
    OLEG KISSELEV; Fiscal Year: 2007
    ..abstract_text> ..
  21. IMAGING OF ROD OUTER SEGMENT BY CRYO-ELECTRON TOMOGRAPHY
    Krzysztof Palczewski; Fiscal Year: 2008
    ..These studies will add significantly to our understanding of the normal and disease stage organization of the rod outer segments. [unreadable] [unreadable] [unreadable]..
  22. Melanopsin-based form vision in photoreceptor disease
    MICHAEL SANDBERG; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  23. Point-of-Care Measurement of Glycated Hemoglobin
    MARGO COHEN; Fiscal Year: 2004
    ....
  24. Reading Enhancement for Patients with Visual Field Loss
    MICHAEL SANDBERG; Fiscal Year: 2004
    ....
  25. STRUCTURAL STUDIES OF G PROTEIN-COUPLED RECEPTORS
    KRZYSZTOF NMI PALCZEWSKI; Fiscal Year: 2010
    ..The importance of the protein family for human health makes this effort worthwhile. ..
  26. SPECTROSCOPIC AND RELATED STUDIES ON LENS MEMBRANE LIPID
    Douglas Borchman; Fiscal Year: 2003
    ..An understanding of these alterations will facilitate the development of therapies to prevent or perhaps even reverse these changes. ..
  27. PHOSPHODIESTERASES IN PHOTORECEPTOR METABOLISM & DISEASE
    Debora Farber; Fiscal Year: 2003
    ..Overall, these studies are designed to increase our knowledge of the etiology and possibly the pathogenesis of certain hereditary retinal degenerations and open new avenues for future therapeutic modalities. ..
  28. Pancreatic Development in Modeling Pancreatic Disease
    Paul Grippo; Fiscal Year: 2003
    ..Targeting pancreatic progenitor cells with various genetic alterations will provide valuable information for the developmental biologist and clinical pathologist alike. ..
  29. Molecular Mechanisms in Retinal Degeneration
    Debora B Farber; Fiscal Year: 2011
    ....
  30. Culture and Transplantation of Human Retinal Spheres
    DAVID GAMM; Fiscal Year: 2008
    ..Together, these experiments are designed to build on recent advances in the burgeoning field of stem cell biology and apply them to the basic and clinical science of ophthalmology. ..
  31. MOLECULAR GENETIC DISSECTION OF PHOTORECEPTOR FUNCTION
    WILLIAM PAK; Fiscal Year: 2008
    ..Moreover, it has now been shown over and over again what is learned in Drosophila provide important insights into the corresponding processes in mammals. ..
  32. GLAUCOMA-CONNECTIVE TISSUE CHANGES IN OPTIC NERVE HEAD
    M Rosario Hernandez; Fiscal Year: 2008
    ..abstract_text> ..
  33. Gene Therapy for Usher Syndrome (USH1C)
    Jean Bennett; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  34. Epidermal Mechanisms Opposing Ceramide-Induced Apoptosis
    Yoshikazu Uchida; Fiscal Year: 2009
    ....
  35. Regulation of Angiogenesis via EphB4 Signaling
    JENA STEINLE; Fiscal Year: 2002
    ..These results from both mesenteric and retinal endothelial cells will greatly increase our understanding of Eph B4 receptor regulation of the various stages of angiogenesis. ..
  36. Elevated potassium ion in lacrimal fluid and the health of the ocular surface
    John Ubels; Fiscal Year: 2009
    ..If the high potassium in tears is important for the health of the ocular surface, this information will be useful in the development of improved treatments for dry eye disease. ..
  37. TECNIA 12 BioTWIN Transmission Electron Microscope
    Guido Zampighi; Fiscal Year: 2003
    ..abstract_text> ..
  38. Molecular Analysis of Synaptic Transmission Mutants
    William L Pak; Fiscal Year: 2010
    ..Although this work will be carried out using Drosophila because of its experimental tractability, the work is expected to lead to the identification of novel mammalian homologs and insights into their functions. ..
  39. Conference Proposal: Calcium and Cell Function
    Craig Montell; Fiscal Year: 2004
    ..The topics to be covered at the meeting are of fundamental importance and are relevant to understanding the bases of a diseases such as neurodegeneration, communicative disorders, aging, cancer, kidney and cardiovascular disease. ..
  40. Conference--The Biology and Chemistry of Vision
    Wolfgang Baehr; Fiscal Year: 2003
    ..Proposed sessions include topics on the biology and physiology of photoreceptors, human genetics and retinal disease, as well as gene therapy of recessive and dominant dystrophies. ..
  41. MOLECULAR INDUCTION OF CORNEAL ENDOTHELIAL PROLIFERATION
    Nancy Joyce; Fiscal Year: 2009
    ..If our hypothesis is correct, molecular approaches could tap the residual proliferative capacity of HCEC in older donors by decreasing p21 expression. ..
  42. Vestibulocerebellar function in channelopathy mutants
    John Stahl; Fiscal Year: 2004
    ..Thus, the insights into normal cerebellar function generated by this study should also advance our understanding of mechanisms of heritable neurological disease. ..
  43. Characterizing a genetic history of African populations
    FLOYD REED; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  44. Genetic model of retinal pigment epithelium degeneration
    Douglas Vollrath; Fiscal Year: 2005
    ....
  45. Transgenic/Molecular Approaches for Ocular Albinism
    Debora Farber; Fiscal Year: 2006
    ..abstract_text> ..
  46. Identifying the RP10 gene causing retinitis pigmentosa
    Stephen Daiger; Fiscal Year: 2004
    ..abstract_text> ..
  47. CLEK STUDY CORNEAL TOPOGRAPHY READING CENTER
    Timothy McMahon; Fiscal Year: 2004
    ..This proposal seeks support for a period of five years to provide for salaries, equipment, computer programming support, consultants, supplies and travel. ..
  48. Proteomic Studies of Age Related Macular Degeneration
    John Crabb; Fiscal Year: 2005
    ..The results will help establish a firm link between oxidative damage and the pathogenesis of AMD and provide new opportunities for developing strategies and therapies for preventing or limiting the complications of AMD. ..
  49. Thymosin beta 4 and Autoimmune Ocular Surface Disease
    Gabriel Sosne; Fiscal Year: 2004
    ..abstract_text> ..
  50. Genetic Studies of POAG in Ghana, West Africa
    R Allingham; Fiscal Year: 2005
    ..This dataset can also serve as a foundation for genetic linkage dataset for genome-wide screen to identify new candidate genes and loci in this important population. ..
  51. DEVELOPMENT OF SENSORY/MOTOR SYNAPSES IN THE SPINAL CORD
    Eric Frank; Fiscal Year: 2005
    ....
  52. OCULAR DEVELOPMENT IN INFANCY/EARLY CHILDHOOD
    Donald Mutti; Fiscal Year: 2005
    ..abstract_text> ..
  53. Gene Therapy for Inherited Retinal Degeneration
    Jean Bennett; Fiscal Year: 2007
    ..The ability to rescue photoreceptors in the PDEbeta or abcr -based animal models could ultimately pave the way for genetic therapy as a treatment for blinding retinal diseases. ..
  54. Circadian organization in the aged rodent
    Alec Davidson; Fiscal Year: 2004
    ....
  55. Proteomic Analysis of the Retina
    MONICA JABLONSKI; Fiscal Year: 2007
    ..These studies will also generate the framework for future project periods in which the precise molecular mechanisms and detailed pathways that control photoreceptor outer segment assembly will be determined. [unreadable] [unreadable]..
  56. LIFE AND DEATH OF RETINAL GANGLION CELLS
    Vittorio Porciatti; Fiscal Year: 2007
    ..Such outcomes are significant, since exploiting an animal model for testing neuroprotective strategies that preserve visual function is an important component of future research on treatments for glaucoma. ..
  57. Biophysics of CNS Connexins
    VYTAUTAS VERSELIS; Fiscal Year: 2006
    ..abstract_text> ..
  58. TRANSGENIC STUDIES OF AMYOTROPHIC LATERAL SCLEROSIS
    Han Xiang Deng; Fiscal Year: 2004
    ..To achieve this goal we propose to develop additional transgenic mouse lines that over express successively smaller fragments of SOD 1 polypeptide to determine the smallest segment of SOD 1 that causes ALS. ..
  59. Genoplasty in Ocular Gene Therapy
    JOHN NICKERSON; Fiscal Year: 2004
    ..abstract_text> ..
  60. Pak1 - PIN Pathway in Breast Cancer Progression
    Rakesh Kumar; Fiscal Year: 2008
    ..Our proposed research is significant as this research might form the basis for new advances in identifying novel molecular targets, detecting, preventing and treating breast cancer, by identifying PIN as a key regulatory nodule. ..
  61. Endothelial Transmigration Across the RPE Barrier
    Mary Elizabeth Hartnett; Fiscal Year: 2005
    ..Increased knowledge of the mechanisms that cause this destructive phenomenon may lead to future means to prevent CNV in the neurosensory retina, and thus, reduce vision loss in AMD. ..
  62. VISUAL CYCLE PROTEINS
    John Crabb; Fiscal Year: 2002
    ..The proposed studies will lead to a better understanding of the structure, function and regulation of CRALBP and the visual disorders with which at may be associated. ..
  63. REDOX CONTROL OF FGF GENE EXPRESSION IN AGING RPE
    LEONARD HJELMELAND; Fiscal Year: 2002
    ..Our hypothesis provides a plausible link between cell death in the outer retina and the events of oxidative stress and RPE aging and may provide new approaches for the understanding and treatment of AMD. ..
  64. HER2 Pathway in Breast Cancer Progression and Treatment
    Rakesh Kumar; Fiscal Year: 2007
    ..abstract_text> ..
  65. The Contact Lens and Dry Eye Study
    Jason Nichols; Fiscal Year: 2006
    ..The long-term objective of this research is to contribute to a better understanding of the etiology and risk factors for contact lens-related dry eye so that progress can be made toward its prevention. ..
  66. BIOCHEMICAL BASIS OF KERATOCONUS
    BEATRICE YUE; Fiscal Year: 2007
    ..We hope to gain a greater understanding toward the etiologic basis of KC and provide insights to ultimately lead to prevention and treatment of this corneal disease. ..
  67. OCULAR MELANOMA
    Judy Kim; Fiscal Year: 2003
    ..Standardized clinical and data collection procedures will be employed, and standardized forms will be used in all centers. Central training and certification of all study staff will be required. ..
  68. BIOLOGY OF TRABECULAR MESHWORK IN HEALTH AND DISEASE
    BEATRICE YUE; Fiscal Year: 2009
    ..The overall goal of our proposal is to illustrate the mechanisms to provide a deeper understanding regarding the pathogenesis of glaucomas. ..