nf kappa b

Summary

Summary: Ubiquitous, inducible, nuclear transcriptional activator that binds to enhancer elements in many different cell types and is activated by pathogenic stimuli. The NF-kappa B complex is a heterodimer composed of two DNA-binding subunits: NF-kappa B1 and relA.

Top Publications

  1. ncbi A human homologue of the Drosophila Toll protein signals activation of adaptive immunity
    R Medzhitov
    Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520 8011, USA
    Nature 388:394-7. 1997
  2. ncbi Nuclear factor-kappaB: the enemy within
    Bharat B Aggarwal
    Cytokine Research Laboratory, Department of Experimental Therapeutics, Unit 143, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Cancer Cell 6:203-8. 2004
  3. ncbi NF-kappaB regulation in the immune system
    Qiutang Li
    The Salk Institute, Laboratory of Genetics, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
    Nat Rev Immunol 2:725-34. 2002
  4. ncbi Cellular survival: a play in three Akts
    S R Datta
    Division of Neuroscience, Children s Hospital and Department of Neurobiology, Harvard Medical School, Boston, MA 02115 USA
    Genes Dev 13:2905-27. 1999
  5. doi Shared principles in NF-kappaB signaling
    Matthew S Hayden
    Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06510, USA
    Cell 132:344-62. 2008
  6. ncbi NF-kappaB at the crossroads of life and death
    Michael Karin
    Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0636, USA
    Nat Immunol 3:221-7. 2002
  7. ncbi Integrating cell-signalling pathways with NF-kappaB and IKK function
    Neil D Perkins
    College of Life Sciences, Division of Gene Regulation and Expression, James Black Centre, Dow Street, University of Dundee, Dundee, DD1 5EH, Scotland, UK
    Nat Rev Mol Cell Biol 8:49-62. 2007
  8. ncbi De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling
    Ingrid E Wertz
    Department of Molecular Oncology, School of Medicine, University of California, Davis, Davis, California 95616, USA
    Nature 430:694-9. 2004
  9. pmc NF-kappaB: a key role in inflammatory diseases
    P P Tak
    Division of Clinical Immunology and Rheumatology, Academic Medical Center, Amsterdam, The Netherlands
    J Clin Invest 107:7-11. 2001
  10. ncbi NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses
    S Ghosh
    Section of Immunobiology, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Annu Rev Immunol 16:225-60. 1998

Research Grants

Detail Information

Publications341 found, 100 shown here

  1. ncbi A human homologue of the Drosophila Toll protein signals activation of adaptive immunity
    R Medzhitov
    Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520 8011, USA
    Nature 388:394-7. 1997
    ..1, which is required for the activation of naive T cells...
  2. ncbi Nuclear factor-kappaB: the enemy within
    Bharat B Aggarwal
    Cytokine Research Laboratory, Department of Experimental Therapeutics, Unit 143, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Cancer Cell 6:203-8. 2004
    ..Furthermore, there exists genetic evidence that NF-kappaB mediates tumorigenesis. Thus, suppression of NF-kappaB activation should be effective in the prevention and treatment of cancer...
  3. ncbi NF-kappaB regulation in the immune system
    Qiutang Li
    The Salk Institute, Laboratory of Genetics, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
    Nat Rev Immunol 2:725-34. 2002
    ..We also discuss the role of NF-kappaB proteins as potential therapeutic targets in clinical applications...
  4. ncbi Cellular survival: a play in three Akts
    S R Datta
    Division of Neuroscience, Children s Hospital and Department of Neurobiology, Harvard Medical School, Boston, MA 02115 USA
    Genes Dev 13:2905-27. 1999
  5. doi Shared principles in NF-kappaB signaling
    Matthew S Hayden
    Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06510, USA
    Cell 132:344-62. 2008
    ..Here, we attempt to synthesize some of the basic principles that have emerged from studies of NF-kappaB, and we aim to generate a more unified view of NF-kappaB regulation...
  6. ncbi NF-kappaB at the crossroads of life and death
    Michael Karin
    Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0636, USA
    Nat Immunol 3:221-7. 2002
    ..However, NF-kappaB cannot function alone. A variety of mechanisms exist to modulate its activity and thereby affect the ultimate outcome of a cell's fate...
  7. ncbi Integrating cell-signalling pathways with NF-kappaB and IKK function
    Neil D Perkins
    College of Life Sciences, Division of Gene Regulation and Expression, James Black Centre, Dow Street, University of Dundee, Dundee, DD1 5EH, Scotland, UK
    Nat Rev Mol Cell Biol 8:49-62. 2007
    ..This crosstalk constitutes a decision-making process that determines the consequences of NF-kappaB and IKK activation and, ultimately, cell fate...
  8. ncbi De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling
    Ingrid E Wertz
    Department of Molecular Oncology, School of Medicine, University of California, Davis, Davis, California 95616, USA
    Nature 430:694-9. 2004
    ..We also provide an example of a protein containing separate ubiquitin ligase and DUB domains, both of which participate in mediating a distinct regulatory effect...
  9. pmc NF-kappaB: a key role in inflammatory diseases
    P P Tak
    Division of Clinical Immunology and Rheumatology, Academic Medical Center, Amsterdam, The Netherlands
    J Clin Invest 107:7-11. 2001
  10. ncbi NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses
    S Ghosh
    Section of Immunobiology, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Annu Rev Immunol 16:225-60. 1998
    ..In this review, we discuss some of these recent findings and their implications for the study of NF-kappa B...
  11. ncbi IKKbeta/NF-kappaB activation causes severe muscle wasting in mice
    Dongsheng Cai
    Research Division, Joslin Diabetes Center, One Joslin Place, Boston, MA 02215, USA
    Cell 119:285-98. 2004
    ....
  12. ncbi The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5
    F Hayashi
    Department of Immunology, University of Washington, Seattle 98195, USA
    Nature 410:1099-103. 2001
    ..Our data suggest that TLR5, a member of the evolutionarily conserved Toll-like receptor family, has evolved to permit mammals specifically to detect flagellated bacterial pathogens...
  13. ncbi Signalling pathways of the TNF superfamily: a double-edged sword
    Bharat B Aggarwal
    Cytokine Research Section, Department of Bioimmunotherapy, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Box 143, Houston, Texas, USA
    Nat Rev Immunol 3:745-56. 2003
    ..These cytokines either induce cellular proliferation, survival, differentiation or apoptosis. Blockers of TNF have been approved for human use in treating TNF-linked autoimmune diseases in the United States and other countries...
  14. ncbi IAP antagonists induce autoubiquitination of c-IAPs, NF-kappaB activation, and TNFalpha-dependent apoptosis
    Eugene Varfolomeev
    Department of Protein Engineering, Genentech, Inc, South San Francisco, CA 94080, USA
    Cell 131:669-81. 2007
    ..Through their ubiquitin E3 ligase activities c-IAP1 and c-IAP2 promote proteasomal degradation of NIK, the central ser/thr kinase in the noncanonical NF-kappaB pathway...
  15. ncbi Signaling to NF-kappaB by Toll-like receptors
    Taro Kawai
    Department of Host Defense and Exploratory Research for Advanced Technology, Japan Science and Technology Agency, Research Institute for Microbial Diseases, Osaka University, 3 1 Yamada oka, Suita, Osaka 565 0871, Japan
    Trends Mol Med 13:460-9. 2007
    ..Here, we review recent progress in our understanding of the role of NF-kappaB in TLR signaling pathways and discuss potential implications for molecular medicine...
  16. ncbi IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway
    Katherine A Fitzgerald
    Division of Infectious Disease and Immunology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Nat Immunol 4:491-6. 2003
    ..Thus, IKKepsilon and TBK1 have a pivotal role in coordinating the activation of IRF3 and NF-kappaB in the innate immune response...
  17. ncbi NF-kappaB and the immune response
    M S Hayden
    Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06510, USA
    Oncogene 25:6758-80. 2006
    ..This review, therefore, describes the role of the NF-kappaB pathway in the development and functioning of the immune system...
  18. ncbi IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction
    Taro Kawai
    Exploratory Research for Advanced Technology, Japan Science and Technology Agency
    Nat Immunol 6:981-8. 2005
    ..Knockdown' of IPS-1 by small interfering RNA blocked interferon induction by virus infection. Thus, IPS-1 is an adaptor involved in RIG-I- and Mda5-mediated antiviral immune responses...
  19. ncbi TLR signaling
    T Kawai
    Exploratory Research for Advanced Technology, Japan Science and Technology Agency, 3 1 Yamada oka, Suita, Osaka 565 0871, Japan
    Cell Death Differ 13:816-25. 2006
    ..This review outlines the recent advances in our understanding of TLR-signaling pathways and their roles in immune responses. Further, we also discuss a new concept of TLR-independent mechanisms for recognition of microbial pathogens...
  20. ncbi Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes
    Olivier Micheau
    Institute of Biochemistry, University of Lausanne, BIL Biomedical Research Center, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
    Cell 114:181-90. 2003
    ..Thus, TNFR1-mediated-signal transduction includes a checkpoint, resulting in cell death (via complex II) in instances where the initial signal (via complex I, NF-kappa B) fails to be activated...
  21. pmc NF-kappaB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses
    Konstantin D Taganov
    Division of Biology, California Institute of Technology, 1200 East California Boulevard, Pasadena, CA 91125, USA
    Proc Natl Acad Sci U S A 103:12481-6. 2006
    ....
  22. ncbi NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase
    O N Ozes
    Department of Microbiology and Immunology, Indiana University School of Medicine, The Walther Oncology Center, Indianapolis 46202, USA
    Nature 401:82-5. 1999
    ..Mutation of this amino acid blocks phosphorylation by Akt or TNF and activation of NF-kappaB. These findings indicate that Akt is part of a signalling pathway that is necessary for inducing key immune and inflammatory responses...
  23. ncbi PKC-theta is required for TCR-induced NF-kappaB activation in mature but not immature T lymphocytes
    Z Sun
    Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York 10016, USA
    Nature 404:402-7. 2000
    ..These results indicate that PKC-theta functions in a unique pathway that links the TCR signalling complex to the activation of NF-kappaB in mature T lymphocytes...
  24. ncbi Nod1 detects a unique muropeptide from gram-negative bacterial peptidoglycan
    Stephen E Girardin
    Unite de Pathogenie Microbienne Moleculaire, INSERM U389, Institut Pasteur, 28, rue du Dr Roux, 75724Paris Cedex 15, France
    Science 300:1584-7. 2003
    ..Moreover, we show that in epithelial cells (which represent the first line of defense against invasive pathogens), Nod1is indispensable for intracellular Gram-negative bacterial sensing...
  25. ncbi Signaling to NF-kappaB
    Matthew S Hayden
    Section of Immunobiology and Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Genes Dev 18:2195-224. 2004
    ..In this review, we provide an overview of established NF-kappaB signaling pathways with focus on the current state of research into the mechanisms that regulate IKK activation and NF-kappaB transcriptional activity...
  26. pmc TLR4 links innate immunity and fatty acid-induced insulin resistance
    Hang Shi
    Division of Endocrinology, Department of Medicine, Beth Israel Deaconess Medical Center, and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Clin Invest 116:3015-25. 2006
    ....
  27. ncbi The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses
    Mitsutoshi Yoneyama
    Department of Tumor Cell Biology, Tokyo Metropolitan Institute of Medical Science, Tokyo Metropolitan Organization for Medical Research, 3 18 22 Honkomagome, Bunkyo ku, Tokyo 113 8613, Japan
    Nat Immunol 5:730-7. 2004
    ..Subsequent gene activation by these factors induced antiviral functions, including type I interferon production. Thus, RIG-I is key in the detection and subsequent eradication of the replicating viral genomes...
  28. ncbi Nod1 responds to peptidoglycan delivered by the Helicobacter pylori cag pathogenicity island
    Jérôme Viala
    Groupe d Immunité Innée et Signalisation, Institut National de la Sante et de la Recherche Medicale U389, Institut Pasteur, Paris, France
    Nat Immunol 5:1166-74. 2004
    ..pylori than were wild-type mice. We propose that sensing of H. pylori by Nod1 represents a model for host recognition of noninvasive pathogens...
  29. pmc NF-kappaB is essential for epithelial-mesenchymal transition and metastasis in a model of breast cancer progression
    Margit A Huber
    Department of Physiological Chemistry, Ulm University, Albert Einstein Allee 11, D 89081 Ulm, Germany
    J Clin Invest 114:569-81. 2004
    ....
  30. ncbi NF-kappaB: linking inflammation and immunity to cancer development and progression
    Michael Karin
    Laboratory of Gene Regulation and Signal Transduction, University of California at San Diego School of Medicine, Department of Pharmacology, 9500 Gilman Drive, La Jolla, California 92093 0723, USA
    Nat Rev Immunol 5:749-59. 2005
    ....
  31. ncbi Multiple control of interleukin-8 gene expression
    Elke Hoffmann
    Institute of Pharmacology, Medical School Hannover, Germany
    J Leukoc Biol 72:847-55. 2002
    ..In that way, cells are able to rapidly increase and at the same time, to fine-tune the amount of IL-8 secreted and thereby control the extent of leukocytes attracted to sites of tissue injury...
  32. ncbi The phosphorylation status of nuclear NF-kappa B determines its association with CBP/p300 or HDAC-1
    Haihong Zhong
    Immunobiology Section and Department of Molecular Biophysics and Biochemistry, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06520, USA
    Mol Cell 9:625-36. 2002
    ..Our results demonstrate that phosphorylation of p65 determines whether it associates with either CBP or HDAC-1, ensuring that only p65 entering the nucleus from cytoplasmic NF-kappa B:Ikappa B complexes can activate transcription...
  33. ncbi Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus
    Etienne Meylan
    Department of Biochemistry, University of Lausanne, BIL Biomedical Research Center, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
    Nature 437:1167-72. 2005
    ..Cardif thus functions as an adaptor, linking the cytoplasmic dsRNA receptor RIG-I to the initiation of antiviral programmes...
  34. ncbi The IKK NF-kappa B system: a treasure trove for drug development
    Michael Karin
    Laboratory of Gene Regulation and Signal Transduction Department of Pharmacology, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093 0636, USA
    Nat Rev Drug Discov 3:17-26. 2004
  35. ncbi Lipopolysaccharide activates an innate immune system response in human adipose tissue in obesity and type 2 diabetes
    S J Creely
    Diabetes and Metabolism Research Laboratories, Clinical Sciences Research Institute, Warwick Medical School, Clinical Sciences Bldg, University Hospital Coventry and Warwickshire, Clifford Bridge Road, Coventry CV2 2DX, West Midlands, UK
    Am J Physiol Endocrinol Metab 292:E740-7. 2007
    ..Thus, increased adiposity may increase proinflammatory cytokines and therefore contribute to the pathogenic risk of T2DM...
  36. pmc Frequent engagement of the classical and alternative NF-kappaB pathways by diverse genetic abnormalities in multiple myeloma
    Christina M Annunziata
    Metabolism Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA
    Cancer Cell 12:115-30. 2007
    ..These data demonstrate that addiction to the NF-kappaB pathway is frequent in myeloma and suggest that IKKbeta inhibitors hold promise for the treatment of this disease...
  37. pmc Promiscuous mutations activate the noncanonical NF-kappaB pathway in multiple myeloma
    Jonathan J Keats
    Comprehensive Cancer Center, Mayo Clinic Arizona, Scottsdale, AZ 85259, USA
    Cancer Cell 12:131-44. 2007
    ..These results highlight the critical importance of the NF-kappaB pathway in the pathogenesis of multiple myeloma...
  38. ncbi Post-translational modifications regulating the activity and function of the nuclear factor kappa B pathway
    N D Perkins
    Division of Gene Regulation and Expression, University of Dundee, Dundee, Scotland, UK
    Oncogene 25:6717-30. 2006
    ....
  39. ncbi Understanding RAGE, the receptor for advanced glycation end products
    Angelika Bierhaus
    J Mol Med (Berl) 83:876-86. 2005
    ..These data suggest that, just as RAGE is a multiligand receptor, its ligands are also likely to recognize several receptors in mediating their biologic effects...
  40. pmc Evasion of Toll-like receptor 5 by flagellated bacteria
    Erica Andersen-Nissen
    Institute for Systems Biology, 1441 North 34th Street, Seattle, WA 98103, USA
    Proc Natl Acad Sci U S A 102:9247-52. 2005
    ....
  41. ncbi Circuitry of nuclear factor kappaB signaling
    Alexander Hoffmann
    Signaling Systems Laboratory, Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093, USA
    Immunol Rev 210:171-86. 2006
    ..Understanding the genetic regulatory circuitry of NF-kappaB functionalities involves system-wide measurements, biophysical studies, and computational modeling...
  42. pmc Transcriptional activation of the NF-kappaB p65 subunit by mitogen- and stress-activated protein kinase-1 (MSK1)
    Linda Vermeulen
    Department of Molecular Biology, University of Gent VIB, K L Ledeganckstraat 35, B 9000 Gent, Belgium
    EMBO J 22:1313-24. 2003
    ..This effect represents, together with phosphorylation of nucleosome components such as histone H3, an essential step leading to selective transcriptional activation of NF-kappaB-dependent gene expression...
  43. ncbi TAB2 and TAB3 activate the NF-kappaB pathway through binding to polyubiquitin chains
    Atsuhiro Kanayama
    Department of Molecular Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Mol Cell 15:535-48. 2004
    ..These results indicate that polyubiquitin binding domains represent a new class of signaling domains that regulate protein kinase activity through a nonproteolytic mechanism...
  44. ncbi NF-kappa B: ten years after
    P A Baeuerle
    Tularik Inc, South San Francisco, California 94080, USA
    Cell 87:13-20. 1996
  45. ncbi The tumour suppressor CYLD negatively regulates NF-kappaB signalling by deubiquitination
    Andrew Kovalenko
    Department of Biological Chemistry, The Weizmann Institute of Science, 76100 Rehovot, Israel
    Nature 424:801-5. 2003
    ..Truncations of CYLD found in cylindromatosis result in reduced enzymatic activity, indicating a link between impaired deubiquitination of CYLD substrates and human pathophysiology...
  46. ncbi LPS induction of gene expression in human monocytes
    M Guha
    Departments of Immunology, C-204, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Cell Signal 13:85-94. 2001
    ..These signaling pathways in turn activate a variety of transcription factors that include NF-kappaB (p50/p65) and AP-1 (c-Fos/c-Jun), which coordinate the induction of many genes encoding inflammatory mediators...
  47. ncbi Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3
    Rashu B Seth
    Howard Hughes Medical Institute, Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Cell 122:669-82. 2005
    ..The transmembrane domain targets MAVS to the mitochondria, implicating a new role of mitochondria in innate immunity...
  48. ncbi The dorsoventral regulatory gene cassette spätzle/Toll/cactus controls the potent antifungal response in Drosophila adults
    B Lemaitre
    Institut de Biologie Moléculaire at Cellulaire, UPR 9022 du Centre National de la Recherche Scientifique, Strasbourg, France
    Cell 86:973-83. 1996
    ..Antibacterial genes are induced either by a distinct pathway involving the immune deficiency gene (imd) or by combined activation of both imd and dorsoventral pathways...
  49. ncbi Cell activation and apoptosis by bacterial lipoproteins through toll-like receptor-2
    A O Aliprantis
    Skirball Institute and Department of Microbiology, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
    Science 285:736-9. 1999
    ..Thus, hTLR2 is a molecular link between microbial products, apoptosis, and host defense mechanisms...
  50. ncbi The IkappaB kinase complex (IKK) contains two kinase subunits, IKKalpha and IKKbeta, necessary for IkappaB phosphorylation and NF-kappaB activation
    E Zandi
    Department of Pharmacology, University of California at San Diego, La Jolla 92093 0636, USA
    Cell 91:243-52. 1997
    ..While the interactions between IKKalpha and IKKbeta may be mediated through their leucine zipper motifs, their helix-loop-helix motifs may be involved in interactions with essential regulatory subunits...
  51. pmc NF-kappaB is a negative regulator of IL-1beta secretion as revealed by genetic and pharmacological inhibition of IKKbeta
    Florian R Greten
    Second Department of Medicine, Klinikum rechts der Isar, Technical University Munich, 81675 Germany
    Cell 130:918-31. 2007
    ..These results unravel an unanticipated role for IKKbeta-dependent NF-kappaB signaling in the negative control of IL-1beta production and highlight potential complications of long-term IKKbeta inhibition...
  52. ncbi RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems
    Koichi Kobayashi
    Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Nature 416:194-9. 2002
    ..Rip2 is therefore a signal transducer and integrator of signals for both the innate and adaptive immune systems...
  53. ncbi Duration of nuclear NF-kappaB action regulated by reversible acetylation
    - Chen Lf
    Gladstone Institute of Virology and Immunology, Department of Medicine, University of California, San Francisco, CA 94141, USA
    Science 293:1653-7. 2001
    ....
  54. ncbi Oscillations in NF-kappaB signaling control the dynamics of gene expression
    D E Nelson
    Centre for Cell Imaging, School of Biological Sciences, Bioscience Research Building, Crown Street, Liverpool, L69 7ZB, UK
    Science 306:704-8. 2004
    ..The functional consequences of NF-kappaB signaling may thus depend on number, period, and amplitude of oscillations...
  55. pmc Constitutive nuclear factor kappaB activity is required for survival of activated B cell-like diffuse large B cell lymphoma cells
    R E Davis
    Metabolism Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-1374, USA
    J Exp Med 194:1861-74. 2001
    ....
  56. ncbi Phosphorylation of NF-kappaB and IkappaB proteins: implications in cancer and inflammation
    Patrick Viatour
    Laboratory of Medical Chemistry and Human Genetics, CHU, Sart Tilman, Center for Biomedical Integrated Genoproteomics, University of Liege, Belgium
    Trends Biochem Sci 30:43-52. 2005
    ....
  57. ncbi Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3
    L Alexopoulou
    Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut, 06520, USA
    Nature 413:732-8. 2001
    ..Moreover, poly(I:C) can induce activation of NF-kappaB and mitogen-activated protein (MAP) kinases independently of MyD88, and cause dendritic cells to mature...
  58. ncbi Cysteine 38 in p65/NF-kappaB plays a crucial role in DNA binding inhibition by sesquiterpene lactones
    A J García-Piñeres
    Institute of Pharmaceutical Biology, Albert Ludwigs Universitat Freiburg, Stefan Meier Strasse 19, 79104 Freiburg, Germany
    J Biol Chem 276:39713-20. 2001
    ..Although a slight inhibition of IkappaB degradation was detected for all SLs, the amount of remaining IkappaB was too low to explain the observed NF-kappaB inhibition...
  59. ncbi CYLD is a deubiquitinating enzyme that negatively regulates NF-kappaB activation by TNFR family members
    Eirini Trompouki
    Institute of Immunology, Biomedical Sciences Research Center Alexander Fleming, 34 Alexander Fleming Street, Vari 16672, Greece
    Nature 424:793-6. 2003
    ..These results indicate that CYLD is a negative regulator of the cytokine-mediated activation of NF-kappaB that is required for appropriate cellular homeostasis of skin appendages...
  60. ncbi The ubiquitin-modifying enzyme A20 is required for termination of Toll-like receptor responses
    David L Boone
    Department of Medicine, University of California at San Francisco, San Francisco, California 94143 0451, USA
    Nat Immunol 5:1052-60. 2004
    ..The critical function of this deubiquitinating enzyme in the restriction of TLR signals emphasizes the importance of the regulation of ubiquitin conjugation in innate immune cells...
  61. pmc MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4
    R Shimazu
    Department of Immunology, Saga Medical School, Saga, Japan
    J Exp Med 189:1777-82. 1999
    ..MD-2 is thus a link between TLR4 and LPS signaling. Identification of this new receptor complex has potential implications for understanding host defense, as well as pathophysiologic, mechanisms...
  62. ncbi NF-kB in development and progression of human cancer
    Xavier Dolcet
    Department of Pathology and Molecular Genetics, Hospital Universitari Arnau de Vilanova, University of Lleida, Av Alcalde Rovira Roure 80, 25198, Lleida, Spain
    Virchows Arch 446:475-82. 2005
    ..In recent years, numerous studies have focused on elucidating the functional consequences of NF-kB activation as well as its signaling mechanisms. NF-kB has turned out to be an interesting therapeutic target for treatment of cancer...
  63. ncbi Nuclear factor-kappaB inhibitors as sensitizers to anticancer drugs
    Chikashi Nakanishi
    Tokyo Metropolitan Cancer and Infectious Disease Center, Komagome Hospital, 3 18 22, Honkomagome, Bunkyoku, Tokyo 113 8677, Japan
    Nat Rev Cancer 5:297-309. 2005
    ..What evidence is there that inhibitors of NF-kappaB might promote apoptosis in cancer cells and can NF-kappaB inhibitors be used to overcome resistance to chemotherapeutic agents?..
  64. pmc Acetylation of RelA at discrete sites regulates distinct nuclear functions of NF-kappaB
    Lin Feng Chen
    Gladstone Institute of Virology and Immunology, University of California at San Francisco, San Francisco, CA 94141, USA
    EMBO J 21:6539-48. 2002
    ..Together, these findings highlight how site-specific acetylation of RelA differentially regulates distinct biological activities of the NF-kappaB transcription factor complex...
  65. ncbi IkappaB kinases phosphorylate NF-kappaB p65 subunit on serine 536 in the transactivation domain
    H Sakurai
    Discovery Research Laboratory, Tanabe Seiyaku Co, Ltd, 16 89 Kashima 3 chome, Yodogawa ku, Osaka 532 8505, Japan
    J Biol Chem 274:30353-6. 1999
    ..Furthermore, activation of IKKs by NF-kappaB-inducing kinase induced phosphorylation of p65 in vivo. Our finding, together with previous observations, suggests dual roles for IKK complex in the regulation of NF-kappaB.IkappaB complex...
  66. ncbi Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway
    Masahiro Yamamoto
    Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, 3 1 Yamada oka, Suita Osaka 565 0871, Japan
    Science 301:640-3. 2003
    ..These findings demonstrate that TRIF is essential for TLR3- and TLR4-mediated signaling pathways facilitating mammalian antiviral host defense...
  67. ncbi IRAK-M is a negative regulator of Toll-like receptor signaling
    Koichi Kobayashi
    Section of Immunobiology, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06510, USA
    Cell 110:191-202. 2002
    ..Endotoxin tolerance, a protection mechanism against endotoxin shock, was significantly reduced in IRAK-M(-/-) cells. Thus, IRAK-M regulates TLR signaling and innate immune homeostasis...
  68. ncbi Shaping the nuclear action of NF-kappaB
    Lin Feng Chen
    Gladstone Institute of Virology and Immunology, University of California, San Francisco, California 94141, USA
    Nat Rev Mol Cell Biol 5:392-401. 2004
  69. ncbi Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-kappaB
    Thijn R Brummelkamp
    Division of Molecular Carcinogenesis and Center for Biomedical Genetics, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    Nature 424:797-801. 2003
    ..We show that this effect can be relieved by aspirin derivatives that inhibit NF-kappaB activity, which suggests a therapeutic intervention strategy to restore growth control in patients suffering from familial cylindromatosis...
  70. ncbi TNF-R1 signaling: a beautiful pathway
    Guoqing Chen
    Tularik Inc, Two Corporate Drive, South San Francisco, CA 94080, USA
    Science 296:1634-5. 2002
    ..We provide an overview of current knowledge of TNF signaling and introduce an STKE Connections Map that depicts a canonical view of this process...
  71. doi Regulation and function of NF-kappaB transcription factors in the immune system
    Sivakumar Vallabhapurapu
    Laboratory of Gene Regulation and Signal Transduction, Departments of Pharmacology and Pathology, Cancer Center, University of California, San Diego, California 93093, USA
    Annu Rev Immunol 27:693-733. 2009
    ..This recent progress is covered in this review...
  72. doi Involvement of linear polyubiquitylation of NEMO in NF-kappaB activation
    Fuminori Tokunaga
    Department of Biophysics and Biochemistry, Graduate School of Medicine and Cell Biology and Metabolism Group, Graduate School of Frontier Biosciences, Osaka University, Suita, Osaka 565 0871, Japan
    Nat Cell Biol 11:123-32. 2009
    ..These results indicate that LUBAC is involved in the physiological regulation of the canonical NF-kappaB activation pathway through linear polyubiquitylation of NEMO...
  73. ncbi Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection
    Stephen E Girardin
    Unite de Pathogenie Microbienne Moleculaire, INSERM U389, Paris Cedex 15, France
    J Biol Chem 278:8869-72. 2003
    ..Additionally, the characterization of Nod2 as the first pathogen-recognition molecule that detects MDP will help to unravel the well known biological activities of this immunomodulatory compound...
  74. ncbi Nod2, a Nod1/Apaf-1 family member that is restricted to monocytes and activates NF-kappaB
    Y Ogura
    Department of Pathology and Comprehensive Cancer Center, The University of Michigan Medical School, Ann Arbor, MI 48109, USA
    J Biol Chem 276:4812-8. 2001
    ..The identification of Nod2 defines a subfamily of Apaf-1-like proteins that function through RICK to activate a NF-kappaB signaling pathway...
  75. ncbi Role of NF-kappaB and Akt/PI3K in the resistance of pancreatic carcinoma cell lines against gemcitabine-induced cell death
    Alexander Arlt
    1Laboratory of Molecular Gastroenterology and Hepatology, 1st Department of Medicine, University of Kiel, Germany
    Oncogene 22:3243-51. 2003
    ....
  76. ncbi Lipopolysaccharide stimulates the MyD88-independent pathway and results in activation of IFN-regulatory factor 3 and the expression of a subset of lipopolysaccharide-inducible genes
    T Kawai
    Department of Host Defense, Research Institute for Microbial Diseases, Japan Science and Technology Corporation, Osaka University, Osaka, Japan
    J Immunol 167:5887-94. 2001
    ....
  77. pmc TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo
    Jae Hyuck Shim
    Section of Immunobiology and Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Genes Dev 19:2668-81. 2005
    ..Therefore, our studies suggests that TAK1 acts as an upstream activating kinase for IKKbeta and JNK, but not IKKalpha, revealing an unexpectedly specific role of TAK1 in inflammatory signaling pathways...
  78. ncbi Post-activation turn-off of NF-kappa B-dependent transcription is regulated by acetylation of p65
    Rosemary Kiernan
    Laboratoire de Virologie Moleculaire, Institut de Genetique Humaine, Montpellier 34296, France
    J Biol Chem 278:2758-66. 2003
    ..We propose that acetylation of p65 plays a key role in IkappaBetaalpha-mediated attenuation of NF-kappaBeta transcriptional activity which is an important process that restores the latent state in post-induced cells...
  79. pmc NF-kappaB and cancer-identifying targets and mechanisms
    Willscott E Naugler
    Department of Medicine, Division of Gastroenterology and Hepatology, Oregon Health and Sciences University, Portland, USA
    Curr Opin Genet Dev 18:19-26. 2008
    ..This review will focus on recent experimental data supporting the hypothesis that inflammation promotes carcinogenesis, and that NF-kappaB signaling is at the heart of such inflammation...
  80. ncbi A cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappaB
    J A DiDonato
    Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, University of California at San Diego, La Jolla 92093 0636, USA
    Nature 388:548-54. 1997
    ..A component of IKK was molecularly cloned and identified as a serine kinase. IKK turns out to be the long-sought-after protein kinase that mediates the critical regulatory step in NF-kappaB activation...
  81. doi Recruitment of the linear ubiquitin chain assembly complex stabilizes the TNF-R1 signaling complex and is required for TNF-mediated gene induction
    Tobias L Haas
    Division of Apoptosis Regulation, German Cancer Research Center DKFZ, 69120 Heidelberg, Germany
    Mol Cell 36:831-44. 2009
    ..Finally, we demonstrate that sustained stability of the TNF-RSC requires LUBAC's enzymatic activity, thereby adding a third form of ubiquitin linkage to the triggering of TNF signaling by the TNF-RSC...
  82. ncbi Regulation of interleukin-8 gene expression
    K A Roebuck
    Department of Immunology Microbiology, Rush Presbyterian St Luke s Medical Center, Chicago, IL 60612, USA
    J Interferon Cytokine Res 19:429-38. 1999
    ..This review discusses the regulatory role these higher-order synergistic interactions play in IL-8 transcription and in generation of the stimulus-specific and cell type-specific patterns of IL-8 expression...
  83. ncbi Akt stimulates the transactivation potential of the RelA/p65 Subunit of NF-kappa B through utilization of the Ikappa B kinase and activation of the mitogen-activated protein kinase p38
    L V Madrid
    Lineberger Comprehensive Cancer Center, Curriculum in Genetics and Molecular Biology, Department of Biology, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599, USA
    J Biol Chem 276:18934-40. 2001
    ..These studies demonstrate that Akt, functioning through IkappaB kinase and p38, induces the transcription function of NF-kappaB by stimulating the RelA/p65 transactivation subunit of NF-kappaB...
  84. pmc NF-kappa B activation in human breast cancer specimens and its role in cell proliferation and apoptosis
    Debajit K Biswas
    Department of Cancer Biology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 101:10137-42. 2004
    ....
  85. ncbi Introduction to NF-kappaB: players, pathways, perspectives
    T D Gilmore
    Biology Department, Boston University, Boston, MA 02215, USA
    Oncogene 25:6680-4. 2006
    ..The organization and focus of articles included in the following reviews are described, as well as likely future areas of research interest on NF-kappaB...
  86. ncbi Expression of toll-like receptors in human atherosclerotic lesions: a possible pathway for plaque activation
    Kristina Edfeldt
    Center for Molecular Medicine and the Department of Medicine, Karolinska Institute, Stockholm, Sweden
    Circulation 105:1158-61. 2002
    ..To explore the molecular mechanism by which microbe recognition occurs in the artery wall, we characterized the expression of toll-like receptors (TLRs), a family of pathogen pattern recognition receptors, in atherosclerotic lesions...
  87. ncbi The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway
    J Ninomiya-Tsuji
    Department of Molecular Biology, Graduate School of Science, Nagoya University, and CREST, Japan Science and Technology Corporation
    Nature 398:252-6. 1999
    ..Activated TAK1 phosphorylates NIK, which stimulates IKK-alpha activity. Our results indicate that TAK1 links TRAF6 to the NIK-IKK cascade in the IL-1 signalling pathway...
  88. ncbi Essential function for the kinase TAK1 in innate and adaptive immune responses
    Shintaro Sato
    Akira Innate Immunity Project, Exploratory Research for Advanced Technology, Japan Science and Technology Agency
    Nat Immunol 6:1087-95. 2005
    ..However, TAK1-deficient B cells were able to activate NF-kappaB but not the kinase Jnk in response to B cell receptor stimulation. These results collectively indicate that TAK1 is key in the cellular response to a variety of stimuli...
  89. ncbi Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components
    O Takeuchi
    Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Japan
    Immunity 11:443-51. 1999
    ..These results demonstrate that TLR2 and TLR4 recognize different bacterial cell wall components in vivo and TLR2 plays a major role in Gram-positive bacterial recognition...
  90. pmc Is NF-kappaB a good target for cancer therapy? Hopes and pitfalls
    Veronique Baud
    Institut Cochin, Universite Paris Descartes, CNRS UMR 8104, 75014, Paris, France
    Nat Rev Drug Discov 8:33-40. 2009
    ..The therapeutic potential and benefit of targeting NF-kappaB in cancer, and the possible complications and pitfalls of such an approach, are explored...
  91. ncbi Discrimination of bacterial lipoproteins by Toll-like receptor 6
    O Takeuchi
    Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Suita, Japan
    Int Immunol 13:933-40. 2001
    ..Taken together, these results show that TLR6 recognizes MALP-2 cooperatively with TLR2, and appears to discriminate between the N-terminal lipoylated structures of MALP-2 and lipopeptides derived from other bacteria...
  92. ncbi Nuclear factor-kappaB in cancer development and progression
    Michael Karin
    Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, University of California San Diego School of Medicine, 9500 Gilman Drive, La Jolla, California 92093, USA
    Nature 441:431-6. 2006
    ..NF-kappaB might also regulate tumour angiogenesis and invasiveness, and the signalling pathways that mediate its activation provide attractive targets for new chemopreventive and chemotherapeutic approaches...
  93. ncbi Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function
    O Adachi
    Department of Biochemistry, Hyogo College of Medicine, Nishinomiya, Japan
    Immunity 9:143-50. 1998
    ..Taken together, these results demonstrate that MyD88 is a critical component in the signaling cascade that is mediated by IL-1 receptor as well as IL-18 receptor...
  94. pmc Bruton's tyrosine kinase links the B cell receptor to nuclear factor kappaB activation
    U D Bajpai
    Department of Pathology and Program in Immunology, Tufts University School of Medicine and Sackler School of Graduate Biomedical Sciences, Boston, Massachusetts 02111, USA
    J Exp Med 191:1735-44. 2000
    ..Thus, BTK is essential for activation of NF-kappaB via the B cell receptor...
  95. pmc Cathepsin B acts as a dominant execution protease in tumor cell apoptosis induced by tumor necrosis factor
    L Foghsgaard
    Apoptosis Laboratory, Danish Cancer Society, Strandboulevarden 49, DK-2100 Copenhagen, Denmark
    J Cell Biol 153:999-1010. 2001
    ..These data imply that cathepsin B, which is commonly overexpressed in human primary tumors, may have two opposing roles in malignancy, reducing it by its proapoptotic features and enhancing it by its known facilitation of invasion...
  96. ncbi Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease
    J P Hugot
    Fondation Jean Dausset CEPH, 27 rue J Dodu 75010 Paris, France
    Nature 411:599-603. 2001
    ....
  97. ncbi The NF-kappa B and I kappa B proteins: new discoveries and insights
    A S Baldwin
    Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill 27599, USA
    Annu Rev Immunol 14:649-83. 1996
    ....
  98. ncbi The two NF-kappaB activation pathways and their role in innate and adaptive immunity
    Giuseppina Bonizzi
    Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0636, USA
    Trends Immunol 25:280-8. 2004
  99. ncbi The TRAF6 ubiquitin ligase and TAK1 kinase mediate IKK activation by BCL10 and MALT1 in T lymphocytes
    Lijun Sun
    Department of Molecular Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Mol Cell 14:289-301. 2004
    ..These results reveal an oligomerization --> ubiquitination --> phosphorylation cascade that culminates in NF-kappaB activation in T lymphocytes...
  100. pmc Influenza A virus inhibits type I IFN signaling via NF-kappaB-dependent induction of SOCS-3 expression
    Eva K Pauli
    Institute of Molecular Virology IMV, Centre of Molecular Biology of Inflammation ZMBE, WWU Muenster, Germany
    PLoS Pathog 4:e1000196. 2008
    ..The inhibitory effect is at least in part due to the induction of SOCS-3 gene expression, which results in an impaired antiviral response...
  101. ncbi NF-kappaB in cancer: from innocent bystander to major culprit
    Michael Karin
    Department of Pharmacology, School of Medicine, University of California San Diego, La Jolla 92093, USA
    Nat Rev Cancer 2:301-10. 2002
    ..NF-kappaB should therefore receive as much attention from cancer researchers as it has already from immunologists...

Research Grants74

  1. NEUTROPHIL ACTIVATION IN ACUTE LUNG INJURY
    Edward Abraham; Fiscal Year: 2009
    ....
  2. Role of IKK in NSCLC: Modulation of SMRT and NF-kappaB
    Marty W Mayo; Fiscal Year: 2012
    ..The overall goal of this project is use these newly identified gene products as novel therapeutic targets for detection and treatment of NSCLC. ..
  3. Regulation of NFkappaB activity by the Estrogen Receptor
    Kendall W Nettles; Fiscal Year: 2012
    ..We propose to use these synthetic compounds to understand the molecular details of this important anti-inflammatory pathway. ..
  4. Androgen Receptor-JunD Complex Inhibitors to Prevent Prostate Cancer Progression
    Hirak S Basu; Fiscal Year: 2012
    ..The most active agent, thus identified, can be further developed for preclinical and clinical testing to prevent progression of early-stage androgen-dependent PCa to CRPCa. ..
  5. Role of Selectins in Burns and Inhalation Injury
    Daniel Traber; Fiscal Year: 2009
    ..These aims should result in a better understanding of the injury and reduce the mortalities of ARDS patients. ..
  6. SPLENIC TOXICITY OF ANILINE
    M Firoze Khan; Fiscal Year: 2010
    ..These studies will elucidate the mechanisms of aniline-induced splenic toxicity, and will be important in devising strategies to prevent toxicity, and in risk assessment of aniline and other structurally-related aromatic amines. ..
  7. Effect of constitutive Type 2 NF-kB on adipogenesis
    LOTUS KYI LOO; Fiscal Year: 2010
    ....
  8. Diet, Biomarkers and Lung Function
    Rui Jiang; Fiscal Year: 2010
    ..This proposal will prepare the candidate well to apply successfully for R01 on diet, diet-related genes, and gene-diet interactions in lung function and COPD. ..
  9. REGULATION OF NF-KAPPA B
    INDER MOHAN VERMA; Fiscal Year: 2013
    ..We propose to study the molecular mechanism of inflammatory processes by studying the regulation of NF-?B a seminal molecule in the induction of inflammation. ..
  10. Inflammatory Cytokines Link NF-kappaB with Bim Degradation and Metastasis
    Marty W Mayo; Fiscal Year: 2012
    ..Understanding the mechanisms used by inflammatory mediators to stimulate Bim degradation will potentially result in the identification of novel approaches to preventing NSCLC metastasis. ..
  11. MicroRNA-21 in Renal Aging
    Markus Bitzer; Fiscal Year: 2012
    ..Demonstration of this protective relationship for miR-21 will open up the possibility that this micro-RNA could be used therapeutically. ..
  12. Molecular elucidation of the CBM complex in NF-kappaB activation by antigen recep
    Hao Wu; Fiscal Year: 2013
    ..These translocations likely activate NF-kB through MALT1 and Bcl10 overexpression. Collectively, these studies suggest that the CBM complex is an attractive therapeutic target neoplastic disorders of the lymphocytes. ..
  13. Regulation of NF-kappaB in Lung Epithelium by ROS/RNS
    Yvonne M W Janssen-Heininger; Fiscal Year: 2013
    ..Completion of this application will provide new avenues to limit allergic inflammation, and also provide new insights into the anti-inflammatory mechanism of GSTP, which is essentially unknown. ..
  14. Dose Ranging study of the Effects of Alpha Acid on Oxidative Stress
    Pamela Ouyang; Fiscal Year: 2010
    ..This study will determine the effective dose that should be studied in future larger studies powered to evaluate whether alpha lipoic acid therapy improves vascular function. ..
  15. Sex Hormones and the Innate Immune Response to Influenza Infection
    DIONNE ROBINSON; Fiscal Year: 2012
    ..These data and our preliminary studies support the need for an in depth evaluation of the effects of sex steroid hormones on immune responses during influenza A infection. ..
  16. Aldose Reductase: A Regulator of Inflammatory Signals
    KOTA VENKATA RAMANA; Fiscal Year: 2011
    ....
  17. Mechanism of Apoptosis and Inhibition of Tumor Progression and Metastasis by Par-
    Vivek M Rangnekar; Fiscal Year: 2012
    ....
  18. Control of NF-kappaB Activity
    ALBERT SIDNEY BALDWIN; Fiscal Year: 2013
    ..abstract_text> ..
  19. Cohort Study of Glucosamine and Chondroitin Supplement Use and Cancer Risk
    Emily White; Fiscal Year: 2012
    ..In addition, if there are observed protective associations of glucosamine and/or chondroitin with cancer risk and no major adverse effects, then these supplements would deserve further investigation as cancer preventive drugs. ..
  20. SPORE in Pancreatic Cancer
    James Abbruzzese; Fiscal Year: 2009
    ..abstract_text> ..
  21. NEUROCHEMICAL PHARMACOLOGY OF PHENCYCLIDINE
    Kenneth Johnson; Fiscal Year: 2009
    ..The potential role of CREB dephosphorylation as a result of over activation of NMDA receptors will also be assessed in the neurotoxicity of PCP treatment. ..
  22. Epigenetics of Severe Systemic Inflammation
    CHARLES EMORY MCCALL; Fiscal Year: 2013
    ..From these results, novel therapeutic interventions or preventions may be designed to improve the poor outcomes associated with SSI. ..
  23. Genotoxic NF-kB Signaling in Cancer
    Zhaohui Wu; Fiscal Year: 2013
    ....
  24. S-nitrosothiols, NF-KappaB and Inflammation in Acute Lung Injury
    Harvey E Marshall; Fiscal Year: 2012
    ..The knowledge gained from the proposed studies could lead to the development of new therapies that target inflammation in ALI/ARDS and other pulmonary disorders.. ..
  25. Effect of beta-glucan on sepsis
    COURTNI NEWSOME; Fiscal Year: 2009
    ..The potential development of beta-glucan as a therapeutic agent with negligible side effects could aid immunocompromised patients, including those undergoing chemotherapy and those with uncontrolled inflammation. ..
  26. Sepsis and Mediators: the Role of MFG-E8
    Ping Wang; Fiscal Year: 2010
    ..abstract_text> ..
  27. Sp1, kappa-B enhancers and transcriptions in neurons
    STEVEN BARGER; Fiscal Year: 2009
    ..abstract_text> ..
  28. NF-kappaB N-myc in Oncogenic Pathways of the CNS
    Raquel Sitcheran; Fiscal Year: 2010
    ..These studies have the potential to offer new insight into drug design targeting oncogenic pathways regulated by NF-KB and N-myc. ..
  29. CARMA3-mediated NF-kappaB activation in GPCR signaling pathways
    Xin Lin; Fiscal Year: 2010
    ....
  30. Wear Particle Disease and NF-kappa B Signaling
    Stuart B Goodman; Fiscal Year: 2013
    ..The proposed research is important, innovative and clinically relevant;it will suggest potential local pharmacological strategies to mitigate the chronic inflammatory reaction to wear particles and periprosthetic osteolysis. ..
  31. Interleukin-33 and Myocardial Pressure Overload
    Richard T Lee; Fiscal Year: 2013
    ..This proposal addresses a newly-discovered signaling system in the heart that is activated by overloading the heart muscle. Understanding this signaling system could lead to new therapies for preventing heart failure. ..
  32. Motor protein regulation of T cell receptor signaling
    Joel L Pomerantz; Fiscal Year: 2012
    ..abstract_text> ..
  33. Inflammatory Gene Regulation in Diabetic Conditions
    Rama Natarajan; Fiscal Year: 2013
    ..The completed studies could lead to the identification of much needed new biomarkers and therapies for diabetes induced accelerated inflammatory cardiovascular diseases. ..
  34. CD80 and CD86 mediated innate immune response in sepsis
    Anna Nolan; Fiscal Year: 2013
    ..This grant will foster a career focused on understanding the mechanisms underlying inflammation in sepsis with the goal of developing intervensions that reduce mortality in this important disease. ..
  35. Regulation of NF-kappaB and IKK by proinflammatory stimuli
    Michael Karin; Fiscal Year: 2013
    ..The proposed studies will be based on a combination of biochemistry, cell biology, and mouse physiology, an integrated approach that was proven very effective in the past. ..
  36. HOW ENVIRONMENTAL CHEMICALS IMPAIR IMMUNITY
    David Sherr; Fiscal Year: 2009
    ....
  37. Synapt G2-S System with HXMS Automation
    Elizabeth A Komives; Fiscal Year: 2013
    ....
  38. Regulation of Ptf1a in the Developing Nervous System
    David M Meredith; Fiscal Year: 2010
    ..Furthermore, the advancement in our understanding of how spinal neurons are formed should accelerate the progress in treating spinal cord trauma. ..
  39. Hypothermia enhances inflammatory cytokine expression via NF-kappa B
    Karen D Fairchild; Fiscal Year: 2010
    ..into an independent investigator elucidating the cellular, molecular, and in vivo effects of hypothermia on NF kappa B-dependent gene expression...
  40. SPORE IN GASTROINTESTINAL CANCER
    Joel Tepper; Fiscal Year: 2009
    ..Career and Developmental Research Programs are also included. ..
  41. Caspase-3 Maintains Uterine Quiescence in a PR and NF-Kappa B Dependent Manner
    Jennifer C Condon; Fiscal Year: 2013
    ....
  42. Mechanisms of PMN and Endothelial-Mediated Lung Inflammation and Injury
    Asrar B Malik; Fiscal Year: 2013
    ..abstract_text> ..
  43. 3'alpha enhancer regulation by AhR and NF-kappaB/Rel proteins
    COURTNEY ELIZABETH WILLIAMS SULENTIC; Fiscal Year: 2011
    ..Results of these studies will also be applicable to the hazard evaluation of other AhR agonists (and antagonists) which include a wide array of chemicals from environmental, dietary and pharmaceutical origin. ..
  44. ACTIVATION OF NF-KB IN GLIAL CELLS AND CNS OF EAE
    Kalipada Pahan; Fiscal Year: 2009
    ..In summary, the results obtained from this proposal will characterize molecular mechanisms for novel biological functions of p40-2 and p40 and delineate their role in the neuroinflammatory disease process of EAE. ..
  45. Mu Center for Botanical Interaction Studies
    Dennis B Lubahn; Fiscal Year: 2013
    ....
  46. NF-kappaB signaling in dystrophic cardiomyopathy
    Jennifer M Peterson; Fiscal Year: 2013
    ..Understanding the role of NF-?B signaling in the heart is critical for determining if we can target this pathway for therapy to slow disease progression and improve quality of life for patients. ..
  47. Investigation of Gene Regulation by NF-kappaB Transcription factors
    Gourisankar Ghosh; Fiscal Year: 2012
    ..The focus of this proposal is to understand the regulation of promoter and transcriptional coactivator recognition by the NF-?B dimers. ..
  48. NF-kappaB in myeloma cell growth and survival in vivo
    Babatunde Oyajobi; Fiscal Year: 2009
    ..The research outlined will provide the basis for generation of novel therapeutic approaches to treat MM. ..
  49. Role of Dab2 in Fatty Liver Disease
    Norbert Leitinger; Fiscal Year: 2013
    ..Specific Aim 2 will determine the mechanistic basis for Dab2-dependent regulation of inflammation and Specific Aim 3 will examine the hypothesis that Dab2 in myeloid cells is essential for cross talk with NK cells in the liver. ..
  50. The non-canonical NF-kappaB pathway in survival and function of T lymphocytes
    David C Parker; Fiscal Year: 2013
    ....
  51. Ras-Induced Lung Cancer: Key Roles for IKK and NF-kappaB
    ALBERT SIDNEY BALDWIN; Fiscal Year: 2013
    ..The proposed experiments have the potential to identify new targetable signaling pathways for treatment of Ras-expressing tumors, including those of the lung. ..
  52. Alcohol, iNOS upregulation, leaky gut & liver disease
    Ali Keshavarzian; Fiscal Year: 2009
    ..Significance: Showing that ALD requires a leaky gut, &that NO &cytoskeletal pathways are involved, could 1) identify drinkers at risk for LD (sugar test);2) lead to therapies to prevent LD in those drinkers unable to abstain. ..
  53. The Role of NF-kappaB in Stromal Macrophage Influence on Breast Cancer Tumorigene
    JENNIFER WEBSTER BRADFORD; Fiscal Year: 2012
    ..Inhibiting the cancer promoting activity of tumor associated macrophages could have major therapeutic benefits for chemoresistant cancers, including breast cancer. ..
  54. NF-kB Signaling and H. Pylori-induced Gastric Disease
    Lin Feng Chen; Fiscal Year: 2013
    ..pylori-initiated inflammatory diseases and cancer. ..
  55. Control of NF-kappaB and Inflammation by COMMD proteins
    Ezra Burstein; Fiscal Year: 2013
    ..Altogether, this proposal will tackle a critically significant problem that will propel the NF-?B field forward by providing important insights into homeostatic mechanisms that prevent persistent inflammation. ..
  56. MEDIATORS AND MODIFIERS OF NF-kappaB IN INSULIN RESISTANCE
    Steven E Shoelson; Fiscal Year: 2010
    ..The findings will improve our understanding of the role of subacute 'inflammation'in insulin resistance, T2D and the metabolic syndrome, and may identify new and more selective targets for therapeutic intervention. ..
  57. Cord Blood is Neuroprotective in a Rat Model of Stroke
    Alison E Willing; Fiscal Year: 2010
    ..The ultimate goal of this research program is to develop an innovative HUCB cell based therapy into a viable clinical option for transplantation in neurodegenerative disease and brain injury. ..
  58. Characterization of the Molecular Mechanism of MVA-induced NF-kappaB Activation
    Stefani Martin; Fiscal Year: 2012
    ..Furthermore, characterization of these viral products will give insights into the function of orthologous proteins produced by variola virus (the causative agent of smallpox) as well. ..
  59. NF-kappaB Signaling and Biology: From Bench to Bedside
    JAMES WAVELL AIKEN; Fiscal Year: 2012
    ..The Keystone Symposia meeting on NF-kappaB Signaling and Biology: From Bench to Bedside will examine how we might fix and cure these problems through the pharmacological targeting of the NF-kappaB system. ..
  60. Mechanisms and Function of NF-kappaB Activation at Dendritic Spines
    MOLLIE KATHERINE MEFFERT; Fiscal Year: 2012
    ....
  61. Cancer-Associated, Interdependent Regulation of mTOR, AKT, and IKK/NF-kappaB
    ALBERT SIDNEY BALDWIN; Fiscal Year: 2013
    ..The studies may identify a single mechanism to suppress mTOR and Akt activity in cancer. The studies are also the first to use a specific IKK? inhibitor for cancer studies. ..
  62. Anticarcinogenic Mechanisms of Tea Constituents
    Zigang Dong; Fiscal Year: 2012
    ..This study is to identify the molecular mechanisms/targets associated with the anti-cancer effects exhibited by tea. Such knowledge will help to develop better cancer preventing agens and design more effective cancer prevention trials. ..
  63. The Role of IKK and NF-kappaB in Controlling mTOR Signaling and TSC Progression
    Hancai Dan; Fiscal Year: 2012
    ..Further studies could lead to the identification of new therapeutic targets and ultimately help develop rational, mechanism- based treatment strategies that target TSC and TSC-related tumors. ..
  64. The Role of IKK and NF-kappaB in Controlling mTOR Signaling and TSC Progression
    Hancai Dan; Fiscal Year: 2013
    ..Further studies could lead to the identification of new therapeutic targets and ultimately help develop rational, mechanism- based treatment strategies that target TSC and TSC-related tumors. ..
  65. MOLECULAR CONTROL OF LIVER REGENERATION
    Rebecca Taub; Fiscal Year: 2000
    ....
  66. GENE EXPRESSION IN REGENERATING AND NEOPLASTIC LIVERS
    Nelson Fausto; Fiscal Year: 2000
    ....
  67. NF-kappaB Regulation by Androgen Receptor
    ALBERT BALDWIN JR; Fiscal Year: 2004
    ..The experiments have the potential to identify a new target in the regulatory cascade associated with androgen/AR signaling and to possibly identify a new target for treatment of androgen-independent cancer. ..
  68. Targeting Akt/NF-kappa beta for Pancreatic Cancer Therapy
    Fazlul Sarkar; Fiscal Year: 2007
    ..These results will provide mechanistic as well as pre-clinical data in support of our hypotheses and may open new and novel avenues for the treatment of human pancreatic cancer. ..
  69. DEFINITION AND REGULATION OF CELLULAR GENES
    Gary Nabel; Fiscal Year: 1993
    ..The goal of this research is to understand the heterogeneity of kappaB binding proteins, to define cDNAs encoding them, and to selectively inhibit their action on the HIV enhancer without affecting cell viability and function...
  70. NEOADJUVANT THERAPY OF OR CANCER BY INHIBITING NF-KAPPAB
    Cun Yu Wang; Fiscal Year: 2003
    ..These studies will uncover the genetic mechanism of oral cancer resistance to cancer therapy and have an important implication in improving the efficacy of oral cancer therapy. ..
  71. CONTROL OF TNF SIGNALING BY NFKB
    ALBERT BALDWIN JR; Fiscal Year: 2003
    ..These experiments will provide new insight into mechanisms whereby TNFalpha initiates and controls critical pathways involved in mediating inflammatory, proliferative and apoptotic functions. ..
  72. ONCOGENIC RAS REQUIRES NFKB ANTIAPOPTOTIC FUNCTION
    MARTY MAYO; Fiscal Year: 2003
    ..factor is known to play a critical role in regulating immune responses, recent evidence has suggested that NF kappa B may be important for oncogene-mediated transformation...
  73. Poxvirus regulation of NF-kB: Mechanisms for virulence
    Joanna Shisler; Fiscal Year: 2009
    ..Results obtained here may prove useful in devising novel strategies to overcome pathogenic effects of vaccinia, with implications for enhancing safety and efficacy of a smallpox vaccine. ..
  74. Nuclear Factor Kappa B in Septic Shock
    Shu Liu; Fiscal Year: 2007
    ..Results from our studies will provide an experimental basis and rationale for targeting NF-KappaB pathway as a novel therapeutic strategy for the treatment of septic shock. ..