pol1 transcription initiation complex proteins

Summary

Summary: Factors that form a preinitiation complex at promoters that are specifically transcribed by RNA POLYMERASE I.

Top Publications

  1. ncbi The role of UBF in regulating the structure and dynamics of transcriptionally active rDNA chromatin
    Elaine Sanij
    Research Division, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia
    Epigenetics 4:374-82. 2009
  2. pmc UBF binding in vivo is not restricted to regulatory sequences within the vertebrate ribosomal DNA repeat
    Audrey C O'Sullivan
    Biomedical Research Centre, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, United Kingdom
    Mol Cell Biol 22:657-68. 2002
  3. pmc UBF levels determine the number of active ribosomal RNA genes in mammals
    Elaine Sanij
    Research Division, Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Australia
    J Cell Biol 183:1259-74. 2008
  4. pmc mTOR-dependent activation of the transcription factor TIF-IA links rRNA synthesis to nutrient availability
    Christine Mayer
    Division of Molecular Biology of the Cell II, German Cancer Research Center, D 69120 Heidelberg, Germany
    Genes Dev 18:423-34. 2004
  5. pmc Dysregulation of upstream binding factor-1 acetylation at K352 is linked to impaired ribosomal DNA transcription in Huntington's disease
    J Lee
    VA Boston Healthcare System, MA, USA
    Cell Death Differ 18:1726-35. 2011
  6. ncbi Growth factor signaling regulates elongation of RNA polymerase I transcription in mammals via UBF phosphorylation and r-chromatin remodeling
    Victor Stefanovsky
    Cancer Research Centre and Department of Medical Biology, Laval University, Hotel Dieu de Quebec, 11 Cote du Palais, G1R 2J6 Québec, Canada
    Mol Cell 21:629-39. 2006
  7. pmc Tor pathway regulates Rrn3p-dependent recruitment of yeast RNA polymerase I to the promoter but does not participate in alteration of the number of active genes
    Jonathan A Claypool
    Department of Biological Chemistry, University of California, Irvine, Irvine, California 92697 1700, USA
    Mol Biol Cell 15:946-56. 2004
  8. pmc Acetylation of TAF(I)68, a subunit of TIF-IB/SL1, activates RNA polymerase I transcription
    V Muth
    Division of Molecular Biology of the Cell II, German Cancer Research Center, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    EMBO J 20:1353-62. 2001
  9. pmc The transcriptional activity of RNA polymerase I is a key determinant for the level of all ribosome components
    Arnaud Laferté
    Laboratoire de Transcription des Gènes, Service de Biochimie et de Génétique Moléculaire, CEA Saclay, F Gif sur Yvette, France
    Genes Dev 20:2030-40. 2006
  10. pmc TOR-dependent reduction in the expression level of Rrn3p lowers the activity of the yeast RNA Pol I machinery, but does not account for the strong inhibition of rRNA production
    Anja Philippi
    Institut fur Biochemie, Genetik und Mikrobiologie, Universitat Regensburg, Universitätsstr 31, 93053 Regensburg, Germany
    Nucleic Acids Res 38:5315-26. 2010

Research Grants

  1. NEPHRECTOMY AT BIRTH AND DURING GROWTH
    RONALD MALT; Fiscal Year: 1992
  2. A Novel HTP Assay for Identification of Compounds that Reduce PNC Prevalence
    Sui Huang; Fiscal Year: 2008
  3. The Perinucleolar Compartment as Breast Cancer Marker
    Sui Huang; Fiscal Year: 2005
  4. PERINUCLEOLAR COMPARTMENT AND CANCER
    Sui Huang; Fiscal Year: 2003
  5. RNA PROCESSING AND RIBONUCLEOPROTEIN
    Thoru Pederson; Fiscal Year: 2001
  6. VIRAL REGULATION OF RIBOSOMAL RNA TRANSCRIPTION
    Lucio Comai; Fiscal Year: 2007
  7. The Werner syndrome protein in CPT-induced DNA damage
    Lucio Comai; Fiscal Year: 2008
  8. RNA Transport Within the Nucleus
    Thoru Pederson; Fiscal Year: 2005
  9. AUTOANTIGEN RNA HELICASE II/GU
    Benigno Valdez; Fiscal Year: 2003
  10. Characterization of p53-independent ARF pathway
    Jason Weber; Fiscal Year: 2007

Scientific Experts

Detail Information

Publications144 found, 100 shown here

  1. ncbi The role of UBF in regulating the structure and dynamics of transcriptionally active rDNA chromatin
    Elaine Sanij
    Research Division, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia
    Epigenetics 4:374-82. 2009
    ..In particular we discuss evidence to suggest that UBF dynamically regulates the active rRNA gene pool during differentiation and malignancy...
  2. pmc UBF binding in vivo is not restricted to regulatory sequences within the vertebrate ribosomal DNA repeat
    Audrey C O'Sullivan
    Biomedical Research Centre, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, United Kingdom
    Mol Cell Biol 22:657-68. 2002
    ..These results are consistent with a structural role for UBF at active nucleolar organizer regions in addition to its recognized role in stable transcription complex formation at the promoter...
  3. pmc UBF levels determine the number of active ribosomal RNA genes in mammals
    Elaine Sanij
    Research Division, Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Australia
    J Cell Biol 183:1259-74. 2008
    ..We also show that the active rRNA gene pool is not static but decreases during differentiation, correlating with diminished UBF expression. Thus, UBF1 levels regulate active rRNA gene chromatin during growth and differentiation...
  4. pmc mTOR-dependent activation of the transcription factor TIF-IA links rRNA synthesis to nutrient availability
    Christine Mayer
    Division of Molecular Biology of the Cell II, German Cancer Research Center, D 69120 Heidelberg, Germany
    Genes Dev 18:423-34. 2004
    ..The results identify a new target formTOR-signaling pathways and elucidate the molecular mechanism underlying mTOR-dependent regulation of RNA synthesis...
  5. pmc Dysregulation of upstream binding factor-1 acetylation at K352 is linked to impaired ribosomal DNA transcription in Huntington's disease
    J Lee
    VA Boston Healthcare System, MA, USA
    Cell Death Differ 18:1726-35. 2011
    ..This novel mechanism suggests that modulation of UBF-mediated rDNA synthesis by CBP may be a therapeutic target for improving neuronal rDNA transcription in HD...
  6. ncbi Growth factor signaling regulates elongation of RNA polymerase I transcription in mammals via UBF phosphorylation and r-chromatin remodeling
    Victor Stefanovsky
    Cancer Research Centre and Department of Medical Biology, Laval University, Hotel Dieu de Quebec, 11 Cote du Palais, G1R 2J6 Québec, Canada
    Mol Cell 21:629-39. 2006
    ..The data suggest a mechanism for coordinating the cotranscriptional assembly of preribosomal particles...
  7. pmc Tor pathway regulates Rrn3p-dependent recruitment of yeast RNA polymerase I to the promoter but does not participate in alteration of the number of active genes
    Jonathan A Claypool
    Department of Biological Chemistry, University of California, Irvine, Irvine, California 92697 1700, USA
    Mol Biol Cell 15:946-56. 2004
    ....
  8. pmc Acetylation of TAF(I)68, a subunit of TIF-IB/SL1, activates RNA polymerase I transcription
    V Muth
    Division of Molecular Biology of the Cell II, German Cancer Research Center, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    EMBO J 20:1353-62. 2001
    ....
  9. pmc The transcriptional activity of RNA polymerase I is a key determinant for the level of all ribosome components
    Arnaud Laferté
    Laboratoire de Transcription des Gènes, Service de Biochimie et de Génétique Moléculaire, CEA Saclay, F Gif sur Yvette, France
    Genes Dev 20:2030-40. 2006
    ....
  10. pmc TOR-dependent reduction in the expression level of Rrn3p lowers the activity of the yeast RNA Pol I machinery, but does not account for the strong inhibition of rRNA production
    Anja Philippi
    Institut fur Biochemie, Genetik und Mikrobiologie, Universitat Regensburg, Universitätsstr 31, 93053 Regensburg, Germany
    Nucleic Acids Res 38:5315-26. 2010
    ..However, our analysis reveals that the dramatic reduction of rRNA synthesis in the immediate cellular response to impaired TOR signalling cannot be explained by the simple down-regulation of Rrn3p and Pol I-Rrn3p levels...
  11. pmc Upstream binding factor association induces large-scale chromatin decondensation
    Danyang Chen
    Department of Cell and Molecular Biology, The Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Proc Natl Acad Sci U S A 101:15106-11. 2004
    ..These studies also provide an in vivo model simulating ribosomal DNA transactivation outside the nucleolus, allowing temporal and spatial analyses of chromatin remodeling and assembly of the pol I transcription machinery...
  12. ncbi Activity of RNA polymerase I transcription factor UBF blocked by Rb gene product
    A H Cavanaugh
    Sigfried and Janet Weis Center for Research, Geisinger Clinic, Danville, Pennsylvania 17822 2618
    Nature 374:177-80. 1995
    ..These results indicate that there is an additional mechanism by which Rb suppresses cell growth, namely that Rb directly represses transcription of the rRNA genes...
  13. pmc Phosphorylation of UBF at serine 388 is required for interaction with RNA polymerase I and activation of rDNA transcription
    R Voit
    Division of Molecular Biology of the Cell II, German Cancer Research Center, D 69120 Heidelberg, Germany
    Proc Natl Acad Sci U S A 98:13631-6. 2001
    ..The results suggest that phosphorylation of UBF represents a powerful means of modulating the assembly of the transcription initiation complex in a proliferation- and cell cycle-dependent fashion...
  14. pmc TBP-TAF complex SL1 directs RNA polymerase I pre-initiation complex formation and stabilizes upstream binding factor at the rDNA promoter
    J Karsten Friedrich
    Division of Gene Regulation and Expression, School of Life Sciences, Wellcome Trust Biocentre, University of Dundee, Scotland, UK
    J Biol Chem 280:29551-8. 2005
    ....
  15. pmc A step subsequent to preinitiation complex assembly at the ribosomal RNA gene promoter is rate limiting for human RNA polymerase I-dependent transcription
    K I Panov
    Division of Gene Regulation and Expression, Wellcome Trust Biocentre, School of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, United Kingdom
    Mol Cell Biol 21:2641-9. 2001
    ..This rate-limiting step in Pol I transcription is likely to be a major target in the regulation of rRNA gene expression...
  16. ncbi Nucleolar transcription factor hUBF contains a DNA-binding motif with homology to HMG proteins
    H M Jantzen
    Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California, Berkeley 94720
    Nature 344:830-6. 1990
    ....
  17. ncbi Is cell size important?
    Renato Baserga
    Department of Cancer Biology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Cell Cycle 6:814-6. 2007
    ..This is probably due to the fact that the IGF-IR is more effective than the InR in translocationg to the nuclei IRS-1, which then binds UBF1, one of the proteins that regulate RNA pol I activity...
  18. pmc Phosphorylation by G1-specific cdk-cyclin complexes activates the nucleolar transcription factor UBF
    R Voit
    Division of Molecular Biology of the Cell II, German Cancer Research Center, D 69120 Heidelberg, Germany
    EMBO J 18:1891-9. 1999
    ..The data demonstrate that UBF is regulated in a cell cycle-dependent manner and suggest a link between G1 cdks-cyclins, UBF phosphorylation and rDNA transcription activation...
  19. ncbi When rDNA transcription is arrested during mitosis, UBF is still associated with non-condensed rDNA
    J Gebrane-Younes
    Institut Jacques Monod, Paris, France
    J Cell Sci 110:2429-40. 1997
    ..It is proposed that modifications of the transcription machinery occurring in prometaphase could explain the arrest of transcription, while reverse modifications in late anaphase could explain activation...
  20. ncbi ERK-dependent phosphorylation of the transcription initiation factor TIF-IA is required for RNA polymerase I transcription and cell growth
    Jian Zhao
    Division of Molecular Biology of the Cell II, German Cancer Research Center, D 69120, Heidelberg, Germany
    Mol Cell 11:405-13. 2003
    ..The results provide a link between growth factor signaling, ribosome production, and cell growth, and may have a major impact on the mechanism of cell transformation...
  21. pmc Two RNA polymerase I subunits control the binding and release of Rrn3 during transcription
    Frederic Beckouët
    CEA, iBiTec S, Service de Biologie Intégrative and Génétique Moléculaire, Gif sur Yvette Cedex F 91191, France
    Mol Cell Biol 28:1596-605. 2008
    ..These data suggest a dual role of the Rpa49-Rpa34 dimer during the recruitment of Rrn3 and its subsequent dissociation from the elongating polymerase...
  22. pmc MAD1 and c-MYC regulate UBF and rDNA transcription during granulocyte differentiation
    Gretchen Poortinga
    Division of Research, Peter MacCallum Cancer Centre, St Andrews Place, East Melbourne, Victoria, Australia
    EMBO J 23:3325-35. 2004
    ....
  23. pmc A specialized form of RNA polymerase I, essential for initiation and growth-dependent regulation of rRNA synthesis, is disrupted during transcription
    P Milkereit
    BZH Biochemie Zentrum Heidelberg, Im Neuenheimer Feld 328, 69120 Heidelberg, Germany
    EMBO J 17:3692-703. 1998
    ..We propose that the formation and disruption of the pol I-Rrn3p complex reflects a molecular switch for regulating rRNA synthesis and its growth rate-dependent regulation...
  24. ncbi Insulin-like growth factor I receptor signaling and nuclear translocation of insulin receptor substrates 1 and 2
    Hongzhi Sun
    Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Mol Endocrinol 17:472-86. 2003
    ..The interaction of nuclear IRS proteins with upstream binding factor 1 constitutes the first direct link of these proteins with the ribosomal DNA transcription machinery...
  25. ncbi Life on a planet of its own: regulation of RNA polymerase I transcription in the nucleolus
    Ingrid Grummt
    Division of Molecular Biology of the Cell II, German Cancer Research Center, D 69120 Heidelberg, Germany
    Genes Dev 17:1691-702. 2003
  26. pmc Pol I transcription and pre-rRNA processing are coordinated in a transcription-dependent manner in mammalian cells
    K Kopp
    Department of Cell and Molecular Biology, Division of Pulmonary and Critical Care Medicine, Feinberg School of Medicine Northwestern University, Chicago, IL 60611, USA
    Mol Biol Cell 18:394-403. 2007
    ..Our observations suggest a model for sequential recruitment of pol I transcription factors and pre-rRNA processing factors to elongating pre-rRNA on an as-needed basis rather than corecruitment to sites of active transcription...
  27. ncbi The giant fibrillar center: a nucleolar structure enriched in upstream binding factor (UBF) that appears in transcriptionally more active sensory ganglia neurons
    Iñigo Casafont
    Department of Anatomy and Cell Biology, and Biomedicine Unit, CSIC, University of Cantabria, Avd Cardenal Herrera Oria s n, 39011 Santander, Spain
    J Struct Biol 159:451-61. 2007
    ..We suggest that the formation of GFCs is associated with a high rate of ribosome biogenesis of the transcriptionally more active large-size neurons...
  28. ncbi xUBF contains a novel dimerization domain essential for RNA polymerase I transcription
    B McStay
    Basic Sciences Division, Hutchinson Cancer Research Center, Seattle, Washington 98104
    Genes Dev 5:1957-68. 1991
    ..This suggests that the gap region has a critical function in transcription distinct from any effect on dimerization or DNA binding...
  29. pmc Activation of mammalian ribosomal gene transcription requires phosphorylation of the nucleolar transcription factor UBF
    R Voit
    Division of Molecular Biology of the Cell II, German Cancer Research Center, Heidelberg
    Nucleic Acids Res 23:2593-9. 1995
    ..The marked differences in the tryptic peptide maps of UBF from growing and serum-starved cells suggest that alterations in the degree of UBF phosphorylation may modulate rRNA synthetic activity in response to extracellular signals...
  30. pmc Differential roles of phosphorylation in the formation of transcriptional active RNA polymerase I
    S Fath
    Biochemie-Zentrum Heidelberg, Im Neuenheimer Feld 328, D-69120 Heidelberg, Germany
    Proc Natl Acad Sci U S A 98:14334-9. 2001
    ..We suggest that phosphorylation at specific sites of pol I is a prerequisite for proper transcription initiation and that phosphorylation/dephosphorylation of pol I is one possibility to modulate cellular rDNA transcription activity...
  31. pmc xUBF and Rib 1 are both required for formation of a stable polymerase I promoter complex in X. laevis
    B McStay
    Hutchinson Cancer Research Center, Basic Sciences Division, Seattle, WA 98104
    EMBO J 10:2297-303. 1991
    ..xUBF is closely similar in amino acid sequence to its previously reported human homolog, hUBF, except that xUBF has only three of the HMG-related domains while hUBF has four and therefore is 63 amino acids longer than xUBF...
  32. pmc Identification of two forms of the RNA polymerase I transcription factor UBF
    D J O'Mahony
    Sigfried and Janet Weis Center for Research, Geisinger Clinic, Danville, PA 17822
    Proc Natl Acad Sci U S A 88:3180-4. 1991
    ..Thus, the existence of different forms of UBF may have important ramifications for transcription by RNA polymerase I...
  33. pmc Transcription factor UAF, expansion and contraction of ribosomal DNA (rDNA) repeats, and RNA polymerase switch in transcription of yeast rDNA
    M Oakes
    Department of Biological Chemistry, University of California, Irvine, Irvine, California 92697 1700, USA
    Mol Cell Biol 19:8559-69. 1999
    ..We discuss the significance of these observations in relation to the plasticity of rDNA tandem repeats and nucleolar structures as well as evolution of the Pol I machinery...
  34. ncbi The mitotically phosphorylated form of the transcription termination factor TTF-1 is associated with the repressed rDNA transcription machinery
    V Sirri
    Institut Jacques Monod, UMR 7592, Paris, France
    J Cell Sci 112:3259-68. 1999
    ..The reorganization of the mitotic rDNA promoter might be induced by phosphorylation of certain components of the rDNA transcription machinery and participate in silencing of rDNA during mitosis...
  35. ncbi Downregulation of the upstream binding factor1 by glycogen synthase kinase3beta in myeloid cells induced to differentiate
    Mingli Liu
    Kimmel Cancer Center, Thomas Jefferson University, 624 Bluemle, Life Sciences Building, Philadelphia, Pennsylvania 19107, USA
    J Cell Biochem 100:1154-69. 2007
    ..Taken together, our results indicate that the induction of granulocytic differentiation in 32D murine myeloid cells causes the degradation of UBF1, via GSK3beta and the proteasome pathway...
  36. pmc Multiple interactions between RNA polymerase I, TIF-IA and TAF(I) subunits regulate preinitiation complex assembly at the ribosomal gene promoter
    Xuejun Yuan
    Division of Molecular Biology of the Cell II, German Cancer Research Center, D 69120 Heidelberg, Germany
    EMBO Rep 3:1082-7. 2002
    ..The results uncover an interphase for essential protein-protein interactions that facilitate Pol I preinitiation complex formation...
  37. pmc DNA looping in the RNA polymerase I enhancesome is the result of non-cooperative in-phase bending by two UBF molecules
    V Y Stefanovsky
    Cancer Research Centre and Department of Medical Biology, Laval University, , , , Canada
    Nucleic Acids Res 29:3241-7. 2001
    ..We use this and previous data to refine the existing enhancesome model and show that HMG boxes 1 and 2 of UBF lie head-to-head along the DNA...
  38. pmc hRRN3 is essential in the SL1-mediated recruitment of RNA Polymerase I to rRNA gene promoters
    G Miller
    Division of Gene Regulation and Expression, School of Life Sciences, Wellcome Trust Biocentre, University of Dundee, Dundee DD1 5EH, UK
    EMBO J 20:1373-82. 2001
    ..We conclude that hRRN3 functions to recruit initiation-competent Pol I to rRNA gene promoters. The essential role for hRRN3 in linking Pol I to SL1 suggests a mechanism for growth control of Pol I transcription...
  39. pmc mTOR-dependent regulation of ribosomal gene transcription requires S6K1 and is mediated by phosphorylation of the carboxy-terminal activation domain of the nucleolar transcription factor UBF
    Katherine M Hannan
    Trescowthick Research Laboratories, Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, USA
    Mol Cell Biol 23:8862-77. 2003
    ..Thus, mTOR plays a critical role in the regulation of ribosome biogenesis via a mechanism that requires S6K1 activation and phosphorylation of UBF...
  40. pmc UBF-binding site arrays form pseudo-NORs and sequester the RNA polymerase I transcription machinery
    Christine Mais
    Biomedical Research Centre, Ninewells Hospital and Medical School, University of Dundee, Dundee, DD1 9SY Scotland, United Kingdom
    Genes Dev 19:50-64. 2005
    ..Furthermore, we propose that UBF mediates recruitment of the pol I machinery to nucleoli independently of promoter elements...
  41. ncbi Mitotic occupancy and lineage-specific transcriptional control of rRNA genes by Runx2
    Daniel W Young
    Department of Cell Biology and Cancer Center, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    Nature 445:442-6. 2007
    ..Our results suggest that lineage-specific control of ribosomal biogenesis may be a fundamental function of transcription factors that govern cell fate...
  42. pmc Putative involvement of the histone acetyltransferase Tip60 in ribosomal gene transcription
    Kalipso Halkidou
    Prostate Research Group, School of Surgical and Reproductive Sciences, The Medical School, University of Newcastle upon Tyne, Newcastle upon Tyne NE2 4HH, UK
    Nucleic Acids Res 32:1654-65. 2004
    ..The present study underlines the importance of acetylation in rDNA transcription and directly implicates Tip60 in the process of ribosomal gene transcription...
  43. pmc The Treacher Collins syndrome (TCOF1) gene product is involved in ribosomal DNA gene transcription by interacting with upstream binding factor
    Benigno C Valdez
    Department of Pharmacology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 101:10709-14. 2004
    ..The elucidation of a physiological function of treacle provides important information of relevance to the molecular dissection of the biochemical pathology of TCS...
  44. ncbi Rrn3 becomes inactivated in the process of ribosomal DNA transcription
    Iwona Hirschler-Laszkiewicz
    Sigfried and Janet Weis Center for Research, Geisinger Clinic, Danville, Pennsylvania 17821, USA
    J Biol Chem 278:18953-9. 2003
    ..Our results indicate that Rrn3 functions stoichiometrically in rDNA transcription and that its ability to associate with RNA polymerase I is lost upon transcription...
  45. ncbi Functional significance of type 1 insulin-like growth factor-mediated nuclear translocation of the insulin receptor substrate-1 and beta-catenin
    Jia Chen
    Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Biol Chem 280:29912-20. 2005
    ..This possibility is supported by the demonstration that enforced nuclear localization of IRS-1 causes nuclear translocation of beta-catenin and transformation of normal mouse embryo fibroblasts (colony formation in soft agar)...
  46. pmc Ribosomal biogenesis induction by high glucose requires activation of upstream binding factor in kidney glomerular epithelial cells
    Meenalakshmi M Mariappan
    Mail Code 7882, Department of Medicine Division of Nephrology, University of Texas Health Science Center, 7703 Floyd Curl Dr, San Antonio, TX 78229, USA
    Am J Physiol Renal Physiol 300:F219-30. 2011
    ....
  47. pmc UBF activates RNA polymerase I transcription by stimulating promoter escape
    Kostya I Panov
    Division of Gene Regulation and Expression, School of Life Sciences, Wellcome Trust Biocentre, University of Dundee, Dundee, UK
    EMBO J 25:3310-22. 2006
    ..We posit that stimulation of promoter escape could be a general mechanism of activator function...
  48. pmc RNA polymerase I-specific subunit CAST/hPAF49 has a role in the activation of transcription by upstream binding factor
    Kostya I Panov
    Division of Gene Regulation and Expression, School of Life Sciences, Wellcome Trust Biocentre, University of Dundee, Dundee DD1 5EH, United Kingdom
    Mol Cell Biol 26:5436-48. 2006
    ....
  49. pmc Phosphorylation by casein kinase 2 facilitates rRNA gene transcription by promoting dissociation of TIF-IA from elongating RNA polymerase I
    Holger Bierhoff
    Molecular Biology of Cell II, German Cancer Research Center, DKFZ ZMBH Alliance, D 69120 Heidelberg, Germany
    Mol Cell Biol 28:4988-98. 2008
    ..The results reveal a mechanism by which the functional interplay between CK2 and FCP1 sustains multiple rounds of Pol I transcription...
  50. ncbi Rb and p130 regulate RNA polymerase I transcription: Rb disrupts the interaction between UBF and SL-1
    K M Hannan
    Henry Hood Research Program, Weis Center for Research, Geisinger Clinic, 100 N Academy Ave, Danville, Pennsylvania, PA 17822 USA
    Oncogene 19:4988-99. 2000
    ..These results suggest that p130 may regulate rDNA transcription in a similar manner to Rb...
  51. ncbi Cloning and sequencing of the genes encoding the hamster ribosomal transcription factors UBF1 and UBF2
    J Bolivar
    Departamento de Bioquimica y Biologia Molecular, Facultad de Ciencias, Universidad de Cadiz, Spain
    Gene 176:257-8. 1996
    ..This insertion is completely conserved among mammalian UBF1 which indicates a putative role of this region on the function of this transcript...
  52. pmc A TBP-containing multiprotein complex (TIF-IB) mediates transcription specificity of murine RNA polymerase I
    D Eberhard
    Institute of Cell and Tumor Biology, German Cancer Research Center, Heidelberg
    Nucleic Acids Res 21:4180-6. 1993
    ....
  53. ncbi An immediate response of ribosomal transcription to growth factor stimulation in mammals is mediated by ERK phosphorylation of UBF
    V Y Stefanovsky
    Cancer Research Centre and Department of Medical Biology, Laval University, Hotel Dieu de Quebec, 11 Cote du Palais, G1R 2J6, Quebec, Canada
    Mol Cell 8:1063-73. 2001
    ..Thus, growth factor regulation of ribosomal transcription likely acts by a cyclic modulation of DNA architecture. The data suggest a central role for ribosome biogenesis in growth regulation...
  54. pmc RNA polymerase I associated factor 53 binds to the nucleolar transcription factor UBF and functions in specific rDNA transcription
    K Hanada
    Department of Biochemistry, University of Tokyo School of Medicine, Japan
    EMBO J 15:2217-26. 1996
    ....
  55. ncbi The cell cycle regulatory factor TAF1 stimulates ribosomal DNA transcription by binding to the activator UBF
    Chih Yin Lin
    Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    Curr Biol 12:2142-6. 2002
    ..Thus, TAF1 may be involved in the coordinate expression of Pol I- and Pol II-transcribed genes required for protein biosynthesis and cell cycle progression...
  56. ncbi Competitive recruitment of CBP and Rb-HDAC regulates UBF acetylation and ribosomal transcription
    G Pelletier
    Cancer Research Centre and Department of Medical Biology Laval University Hotel Dieu de Quebec 11 cote du Palais G1R 2J6, Quebec, Canada
    Mol Cell 6:1059-66. 2000
    ..Thus, PolI transcription is regulated by protein acetylation, and the competitive recruitment of CBP and Rb...
  57. pmc A functional screen in human cells identifies UBF2 as an RNA polymerase II transcription factor that enhances the beta-catenin signaling pathway
    Dorre A Grueneberg
    Aventis Cambridge Genomics Center, Cambridge, Massachusetts 02139, USA
    Mol Cell Biol 23:3936-50. 2003
    ....
  58. ncbi ERK modulates DNA bending and enhancesome structure by phosphorylating HMG1-boxes 1 and 2 of the RNA polymerase I transcription factor UBF
    Victor Y Stefanovsky
    Cancer Research Centre and Department of Medical Biology of Laval University, Centre de recherche de L Hôtel Dieu de Québec, 9 rue McMahon G1R 2J6 Québec, QC, Canada
    Biochemistry 45:3626-34. 2006
    ..The data demonstrate that ERK phosphorylation of UBF prevents DNA bending by its first two HMG boxes, leading to a cooperative unfolding of the enhancesome...
  59. pmc Phenotypic transcription factors epigenetically mediate cell growth control
    Syed A Ali
    Department of Cell Biology and Cancer Center, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
    Proc Natl Acad Sci U S A 105:6632-7. 2008
    ..We conclude that epigenetic control of ribosomal biogenesis by lineage-specific differentiation factors is a general developmental mechanism for coordinate control of cell growth and phenotype...
  60. pmc The splice variants of UBF differentially regulate RNA polymerase I transcription elongation in response to ERK phosphorylation
    Victor Y Stefanovsky
    Cancer Research Centre and Department of Medical Biology of Laval University, Centre de recherche de L Hôtel Dieu de Québec, 9 rue McMahon, G1R 3S3 Québec, QC, Canada
    Nucleic Acids Res 36:5093-101. 2008
    ..Thus, UBF2 functionally simulates a hemi-phosphorylated UBF whose expression may provide a means by which to tune the response of the ribosomal RNA genes to growth factor stimulation...
  61. pmc Direct regulation of rRNA transcription by fibroblast growth factor 2
    Zhi Sheng
    Molecular and Cellular Biology Program, State University of New York, Downstate Medical Center, 450 Clarkson Ave, Brooklyn, NY 11203, USA
    Mol Cell Biol 25:9419-26. 2005
    ..The 18-kDa FGF-2 localizes to rRNA genes and is necessary for the full activation of pre-rRNA synthesis in vivo. Our results demonstrate that 18-kDa FGF-2 directly regulates rRNA transcription...
  62. ncbi The composition of the RNA polymerase I transcription machinery switches from initiation to elongation mode
    Mirko Bier
    Biochemie Zentrum Heidelberg, Im Neuenheimer Feld 328, D 69120 Heidelberg, Germany
    FEBS Lett 564:41-6. 2004
    ..Our data support a model in which the elongating Pol I leaves the initiation factors UAF, CF and Rrn3p close by the promoter...
  63. pmc CK2-mediated stimulation of Pol I transcription by stabilization of UBF-SL1 interaction
    Chih Yin Lin
    Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, 2250 Alcazar Street, Los Angeles, CA 90033, USA
    Nucleic Acids Res 34:4752-66. 2006
    ..These data demonstrate that CK2 is recruited to the rRNA gene promoter and directly regulates Pol I transcription re-initiation by stabilizing the association between UBF and SL1...
  64. ncbi Nucleolar protein upstream binding factor is sequestered into adenovirus DNA replication centres during infection without affecting RNA polymerase I location or ablating rRNA synthesis
    Fiona J Lawrence
    Division of Virology, Department of Cellular and Molecular Medicine, University Walk, University of Bristol, Bristol, BS8 1TD, UK
    J Cell Sci 119:2621-31. 2006
    ..We propose that UBF plays a role in viral DNA replication, further strengthening the role of nucleolar antigens in the adenovirus life cycle...
  65. pmc Acetylation of UBF changes during the cell cycle and regulates the interaction of UBF with RNA polymerase I
    Joachim Meraner
    Division of Molecular Biology, Biocenter, Innsbruck Medical University, A 6020 Innsbruck, Austria
    Nucleic Acids Res 34:1798-806. 2006
    ..The results suggest that acetylation and deacetylation of UBF regulate rRNA synthesis during cell cycle progression...
  66. pmc RNA-polymerase-I-directed rDNA transcription, life and works
    Jackie Russell
    Division of Gene Regulation and Expression, Wellcome Trust Biocentre, University of Dundee, Dundee DD1 5EH, Scotland, UK
    Trends Biochem Sci 30:87-96. 2005
    ....
  67. pmc The nucleolus as a stress sensor: JNK2 inactivates the transcription factor TIF-IA and down-regulates rRNA synthesis
    Christine Mayer
    Division of Molecular Biology of the Cell II, German Cancer Research Center, D 69120 Heidelberg, Germany
    Genes Dev 19:933-41. 2005
    ..Our data identify TIF-IA as a downstream target of the JNK pathway and suggest a critical role of JNK2 to protect rRNA synthesis against the harmful consequences of cellular stress...
  68. pmc Casein kinase 2 associates with initiation-competent RNA polymerase I and has multiple roles in ribosomal DNA transcription
    Tatiana B Panova
    Division of Gene Regulation and Expression, School of Life Sciences, Wellcome Trust Biocentre, University of Dundee, Dundee DD1 5EH, United Kingdom
    Mol Cell Biol 26:5957-68. 2006
    ..Thus, CK2 has the potential to regulate Pol I transcription at multiple levels, in PIC formation, activation, and reinitiation of transcription...
  69. pmc Recruitment of factors linking transcription and processing of pre-rRNA to NOR chromatin is UBF-dependent and occurs independent of transcription in human cells
    José Luis Prieto
    Biomedical Research Centre, Ninewells Hospital and Medical School, University of Dundee, Dundee, DD1 9SY Scotland, United Kingdom
    Genes Dev 21:2041-54. 2007
    ..Taken together, these results highlight the importance of the specialized chromatin structure at active NORs in coordinating early events in ribosome biogenesis and nucleolar formation...
  70. ncbi Reconstitution of transcription factor SL1: exclusive binding of TBP by SL1 or TFIID subunits
    L Comai
    Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California at Berkeley 94720 3204
    Science 266:1966-72. 1994
    ..These results suggest that a mutually exclusive binding specificity for TBP intrinsic to SL1 and TFIID subunits directs the formation of promoter- and RNA polymerase-selective TBP-TAF complexes...
  71. pmc Overlapping functions of the pRb family in the regulation of rRNA synthesis
    S Ciarmatori
    Division of Molecular Biology of the Cell II, German Cancer Research Centre, Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany
    Mol Cell Biol 21:5806-14. 2001
    ..This reflects an ability of p130 to bind and inactivate the upstream binding factor, UBF. The data imply that rRNA synthesis in living cells is subject to redundant control by endogenous pRb and p130...
  72. pmc The role of acetylation in rDNA transcription
    I Hirschler-Laszkiewicz
    The Henry Hood Research Program, Sigfried and Janet Weis Center for Research, The Geisinger Clinic, 100 North Academy Avenue, Danville, PA 17822-2618, USA
    Nucleic Acids Res 29:4114-24. 2001
    ....
  73. pmc Cloning of murine RNA polymerase I-specific TAF factors: conserved interactions between the subunits of the species-specific transcription initiation factor TIF-IB/SL1
    J Heix
    Division of Molecular Biology of the Cell II, German Cancer Research Center, Heidelberg
    Proc Natl Acad Sci U S A 94:1733-8. 1997
    ..rodent promoter selectivity mediated by the TBP-TAFI complex is likely to be the result of cumulative subtle differences between individual subunits that lead to species-specific properties of RNA polymerase I transcription...
  74. pmc Nucleolar components involved in ribosome biogenesis cycle between the nucleolus and nucleoplasm in interphase cells
    D Chen
    Department of Cell and Molecular Biology, Northwestern University Medical School, Chicago, Illinois 60611, USA
    J Cell Biol 153:169-76. 2001
    ....
  75. pmc TIF-IA, the factor mediating growth-dependent control of ribosomal RNA synthesis, is the mammalian homolog of yeast Rrn3p
    J Bodem
    Division of Molecular Biology of the Cell II, German Cancer Research Center, Heidelberg
    EMBO Rep 1:171-5. 2000
    ..We demonstrate that TIF-IA interacts with Pol I in the absence of template DNA, augments Pol I transcription in vivo and rescues transcription in extracts from growth-arrested cells in vitro...
  76. pmc The species-specific RNA polymerase I transcription factor SL-1 binds to upstream binding factor
    W M Hempel
    Weis Center for Research, Geisinger Clinic, Danville, Pennsylvania 17822, USA
    Mol Cell Biol 16:557-63. 1996
    ..These data provide evidence that UBF and SL-1 interact...
  77. ncbi Rrn3 phosphorylation is a regulatory checkpoint for ribosome biogenesis
    Alice H Cavanaugh
    Sigfried and Janet Weis Center for Research, Geisinger Clinic, 100 N Academy Avenue, Danville, PA 17821, USA
    J Biol Chem 277:27423-32. 2002
    ..These results suggest that the phosphorylation state of Rrn3 regulates rDNA transcription by determining the steady-state concentration of the Rrn3.RNA polymerase I complex within the nucleolus...
  78. pmc RNA polymerase I transcription factor Rrn3 is functionally conserved between yeast and human
    B Moorefield
    Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA
    Proc Natl Acad Sci U S A 97:4724-9. 2000
    ..Rrn3 is the first RNA polymerase I-specific transcription factor shown to be functionally conserved between yeast and mammals, suggesting that at least one mechanism that regulates ribosomal RNA synthesis is conserved among eukaryotes...
  79. ncbi A kinetic framework for a mammalian RNA polymerase in vivo
    Miroslav Dundr
    National Cancer Institute NCI, National Institutes of Health, Bethesda, MD 20892, USA
    Science 298:1623-6. 2002
    ..Our data provide a kinetic and mechanistic framework for the function of a mammalian RNA polymerase in living cells...
  80. pmc Human autoantibody to RNA polymerase I transcription factor hUBF. Molecular identity of nucleolus organizer region autoantigen NOR-90 and ribosomal RNA transcription upstream binding factor
    E K Chan
    W M Keck Autoimmune Disease Center, Department of Molecular and Experimental Medicine, Scripps Research Institute, La Jolla, California 92037
    J Exp Med 174:1239-44. 1991
    ..Furthermore, we identified a nucleolar transcription factor as a novel target for human autoimmune response...
  81. pmc TBP-associated factors interact with DNA and govern species specificity of RNA polymerase I transcription
    U Rudloff
    Division of Molecular Biology of the Cell II, German Cancer Research Center, Heidelberg
    EMBO J 13:2611-6. 1994
    ..Thus, evolutionary changes of rDNA promoter sequences have been accompanied by changes in specific TAFs...
  82. pmc New model for the yeast RNA polymerase I transcription cycle
    P Aprikian
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Mol Cell Biol 21:4847-55. 2001
    ..This model accounts for previous observations that rRNA synthesis may be controlled by regulating both promoter accessibility and polymerase activity...
  83. ncbi The role of TBP in rDNA transcription by RNA polymerase I in Saccharomyces cerevisiae: TBP is required for upstream activation factor-dependent recruitment of core factor
    J S Steffan
    Department of Biological Chemistry, University of California, Irvine 92697 1700, USA
    Genes Dev 10:2551-63. 1996
    ..Additionally, we observed an interaction between Rrn9p and Rrn7p both in vitro and in the two-hybrid system; thus, this interaction might also contribute to the recruitment of CF...
  84. ncbi Modifications of both selectivity factor and upstream binding factor contribute to poliovirus-mediated inhibition of RNA polymerase I transcription
    Rajeev Banerjee
    Department of Microbiology, Immunology and Molecular Genetics, University of California Los Angeles, UCLA School of Medicine, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA
    J Gen Virol 86:2315-22. 2005
    ..These results suggested that both SL-1 and UBF are transcriptionally inactivated in PV-infected HeLa cells...
  85. pmc PTEN represses RNA Polymerase I transcription by disrupting the SL1 complex
    Cheng Zhang
    Department of Biochemistry and Molecular Biology, University of Southern California, Keck School of Medicine, Los Angeles, 90033, USA
    Mol Cell Biol 25:6899-911. 2005
    ..Furthermore, PTEN induces dissociation of the SL1 subunits. Together, these results demonstrate that PTEN represses RNA Pol I transcription through a novel mechanism that involves disruption of the SL1 complex...
  86. ncbi The association of TIF-IA and polymerase I mediates promoter recruitment and regulation of ribosomal RNA transcription in Acanthamoeba castellanii
    Joseph C Gogain
    Department of Biochemistry and Molecular Genetics, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Gene Expr 12:259-71. 2005
    ..This downregulation coincides with an altered electrophoretic mobility of TIF-IA, suggesting at least it is phosphorylated...
  87. pmc Epigenetic programming of the rRNA promoter by MBD3
    Shelley E Brown
    Department of Pharmacology and Therapeutics, McGill University, 3655 Sir William Osler Promenade, Montreal, Quebec H3G 1Y6, Canada
    Mol Cell Biol 27:4938-52. 2007
    ..This is the first demonstration that MBD3 is involved in inducing and maintaining the demethylated state of a specific promoter...
  88. pmc The yeast nucleolar protein Cbf5p is involved in rRNA biosynthesis and interacts genetically with the RNA polymerase I transcription factor RRN3
    C Cadwell
    Department of Molecular, Cellular, and Developmental Biology, University of California, Santa Barbara 93106, USA
    Mol Cell Biol 17:6175-83. 1997
    ..A cbf5delta null mutant is not rescued by plasmid pNOY103 containing a yeast 35S rRNA gene under the control of a Pol II promoter, indicating that Cbf5p has one or more essential functions in addition to its role in rRNA transcription...
  89. ncbi Reconstitution of yeast RNA polymerase I transcription in vitro from purified components. TATA-binding protein is not required for basal transcription
    J Keener
    Department of Biological Chemistry, University of California, Irvine, California 92697 1700, USA
    J Biol Chem 273:33795-802. 1998
    ..The role of TBP in pol I transcription is fundamentally different from its role in pol II or pol III transcription...
  90. ncbi Mass spectrometric identification of phosphorylation sites of rRNA transcription factor upstream binding factor
    C Huie Lin
    Department of Molecular Physiology and Biological Physics, University of Virginia, Box 800736, 1300 Jefferson Park Ave, Charlottesville, VA 22908, USA
    Am J Physiol Cell Physiol 292:C1617-24. 2007
    ..e., recruitment of SL1. Moreover, studies provide critical new data regarding multiple additional UBF phosphorylation sites that will require further characterization by the field...
  91. ncbi Regulation of upstream binding factor 1 activity by insulin-like growth factor I receptor signaling
    An Wu
    Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Biol Chem 280:2863-72. 2005
    ....
  92. ncbi The fission yeast protein Ker1p is an ortholog of RNA polymerase I subunit A14 in Saccharomyces cerevisiae and is required for stable association of Rrn3p and RPA21 in RNA polymerase I
    Yukiko Imazawa
    Department of Molecular Biology, Saitama Medical School, 38 Morohongo, Moroyama, Iruma gun, Saitama 350 0495, Japan
    J Biol Chem 280:11467-74. 2005
    ..We also found that Ker1p dissociated from pol I in post-log-phase cells, suggesting that Ker1p is involved in growth-dependent regulation of rDNA transcription...
  93. pmc The recruitment of RNA polymerase I on rDNA is mediated by the interaction of the A43 subunit with Rrn3
    G Peyroche
    Service de Biochimie et de Génétique Moléculaire, CEA Saclay, F 91191 Gif sur Yvette Cedex, France
    EMBO J 19:5473-82. 2000
    ..The existence of mammalian orthologues of A43 and Rrn3 suggests evolutionary conservation of the molecular mechanisms underlying rDNA transcription in eukaryotes...
  94. pmc Condensed mitotic chromatin is accessible to transcription factors and chromatin structural proteins
    Danyang Chen
    Department of Cell and Molecular Biology, The Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    J Cell Biol 168:41-54. 2005
    ..The phase-specific exchanges of nucleosome components during late mitotic phases are consistent with an emerging model of replication independent core histone replacement...
  95. ncbi Net1 stimulates RNA polymerase I transcription and regulates nucleolar structure independently of controlling mitotic exit
    W Shou
    Division of Biology, California Institute of Technology, Pasadena 91125, USA
    Mol Cell 8:45-55. 2001
    ..The independent functions of Net1 link a key event in the cell cycle to nucleolar processes that are fundamental to cell growth...
  96. pmc Multiple protein-protein interactions by RNA polymerase I-associated factor PAF49 and role of PAF49 in rRNA transcription
    Kazuo Yamamoto
    Department of Biochemistry, Saitama Medical School, Iruma gun, Japan
    Mol Cell Biol 24:6338-49. 2004
    ..These results strongly suggest that PAF49/ASE-1 plays an important role in rRNA transcription...
  97. pmc RNA polymerase I remains intact without subunit exchange through multiple rounds of transcription in Saccharomyces cerevisiae
    David A Schneider
    Department of Biological Chemistry, University of California, Irvine, CA 92697, USA
    Proc Natl Acad Sci U S A 101:15112-7. 2004
    ..Thus, Pol I is not a dynamic protein complex but rather a stable enzyme...
  98. ncbi Activation of RNA polymerase I transcription by hepatitis C virus core protein
    Chih Fei Kao
    Institute of Biochemistry, National Yang Ming University, Taipei 112, Taiwan, ROC
    J Biomed Sci 11:72-94. 2004
    ..Notably, the ability of the HCV core protein to upregulate RNA Pol I and Pol III transcription supports its active role in promoting cell growth, proliferation, and the progression of liver carcinogenesis during HCV infection...
  99. ncbi Nucleolar localization of the human telomeric repeat binding factor 2 (TRF2)
    Suisheng Zhang
    Biochemistry, Institute of Molecular Biotechnology, PO Box 100 813, 07708 Jena, Germany
    J Cell Sci 117:3935-45. 2004
    ..These results support the view that the nucleolus may sequester TRF2 and thereby influences its telomeric functions...
  100. ncbi Unusual structure of ribosomal DNA in the copepod Tigriopus californicus: intergenic spacer sequences lack internal subrepeats
    R S Burton
    Marine Biology Research Division 0202, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, CA 92093 0202, USA
    Gene 344:105-13. 2005
    ....
  101. ncbi DNA protein interactions at the rRNA of Saccharomyces cerevisiae
    Francesco Cioci
    Dipartimento di Genetica e Biologia Molecolare, Universita di Roma La Sapienza
    Ital J Biochem 56:81-90. 2007
    ..These in vivo studies help to characterize the molecular basis of important phenomena as the transcriptional silencing and genome stability in yeast...

Research Grants10

  1. NEPHRECTOMY AT BIRTH AND DURING GROWTH
    RONALD MALT; Fiscal Year: 1992
    ..mitochondrial proliferation and gene expression are components of recovery 7. effects of ischemia on renal proteins are controlled by genetic mechanisms...
  2. A Novel HTP Assay for Identification of Compounds that Reduce PNC Prevalence
    Sui Huang; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  3. The Perinucleolar Compartment as Breast Cancer Marker
    Sui Huang; Fiscal Year: 2005
    ..We expect the proposed studies will clarify whether the PNC, an easily detectable cellular structure, could improve the accuracy of breast cancer prognosis and prediction when used in combination with existing markers. ..
  4. PERINUCLEOLAR COMPARTMENT AND CANCER
    Sui Huang; Fiscal Year: 2003
    ..The results of these experiments will provide an important foundation to address the significance of the PNC in malignant cells. ..
  5. RNA PROCESSING AND RIBONUCLEOPROTEIN
    Thoru Pederson; Fiscal Year: 2001
    ..The same studies should provide information on sequences required for nuclear export. These two inter-related projects test the hypothesis that the nucleolus is a more pluri-functional organelle than previously thought. ..
  6. VIRAL REGULATION OF RIBOSOMAL RNA TRANSCRIPTION
    Lucio Comai; Fiscal Year: 2007
    ..These studies will provide important insights into the mechanistic basis of cell transformation by viral oncogenes. ..
  7. The Werner syndrome protein in CPT-induced DNA damage
    Lucio Comai; Fiscal Year: 2008
    ..Taken together, these experiments should provide important mechanistic insights into the process of human aging. ..
  8. RNA Transport Within the Nucleus
    Thoru Pederson; Fiscal Year: 2005
    ..Another aspect of the project will address the intranuclear traffic of these RNAs in relation to proteins known to be involved in nuclear import or RNA export, i.e. the Ran-GTPase and TAP. ..
  9. AUTOANTIGEN RNA HELICASE II/GU
    Benigno Valdez; Fiscal Year: 2003
    ..This study may also provide an impetus for understanding the pathological roles of RH-II/Gu on the elicitation of autoimmune responses. ..
  10. Characterization of p53-independent ARF pathway
    Jason Weber; Fiscal Year: 2007
    ..unreadable] [unreadable]..