dietary proteins

Summary

Summary: Proteins obtained from foods. They are the main source of the essential amino acids.

Top Publications

  1. pmc Diets with high or low protein content and glycemic index for weight-loss maintenance
    Thomas Meinert Larsen
    Department of Human Nutrition, Faculty of Life Sciences, University of Copenhagen, Copenhagen, Denmark
    N Engl J Med 363:2102-13. 2010
  2. pmc Major dietary protein sources and risk of coronary heart disease in women
    Adam M Bernstein
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Circulation 122:876-83. 2010
  3. pmc Dietary protein recommendations and the prevention of sarcopenia
    Douglas Paddon-Jones
    Department of Physical Therapy, Division of Rehabilitation Sciences The University of Texas Medical Branch 301 University Blvd Galveston, Texas 77555 1144, USA
    Curr Opin Clin Nutr Metab Care 12:86-90. 2009
  4. ncbi Dietary patterns, meat intake, and the risk of type 2 diabetes in women
    Teresa T Fung
    Department of Nutrition, Simmons College, Boston, Mass 02115, USA
    Arch Intern Med 164:2235-40. 2004
  5. ncbi Validation of a self-administered food-frequency questionnaire administered in the European Prospective Investigation into Cancer and Nutrition (EPIC) Study: comparison of energy, protein, and macronutrient intakes estimated with the doubly labeled water,
    A Kroke
    Departments of Epidemiology, Intervention Studies, and Nutritional Biochemistry and Physiology, German Institute of Human Nutrition, Potsdam Rehbruecke, Germany
    Am J Clin Nutr 70:439-47. 1999
  6. pmc Protein intake and incident frailty in the Women's Health Initiative observational study
    Jeannette M Beasley
    Clinical Coordinating Center, Women s Health Initiative, Fred Hutchinson Cancer Research Center, Seattle, Washington 98101, USA
    J Am Geriatr Soc 58:1063-71. 2010
  7. ncbi Effects of protein, monounsaturated fat, and carbohydrate intake on blood pressure and serum lipids: results of the OmniHeart randomized trial
    Lawrence J Appel
    Welch Center for Prevention, Epidemiology and Clinical Research, Division of General Internal Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205 2223, USA
    JAMA 294:2455-64. 2005
  8. ncbi Limited and excess dietary protein during gestation affects growth and compositional traits in gilts and impairs offspring fetal growth
    C Rehfeldt
    Leibniz Institute for Farm Animal Biology, 18196 Dummerstorf, Germany
    J Anim Sci 89:329-41. 2011
  9. ncbi A long-term high-protein diet markedly reduces adipose tissue without major side effects in Wistar male rats
    Magali Lacroix
    Unité INRA 914 Physiologie de la Nutrition et Comportement Alimentaire, INA PG, 16 rue Claude Bernard, 75231 Paris Cedex 05, France
    Am J Physiol Regul Integr Comp Physiol 287:R934-42. 2004
  10. ncbi The underappreciated role of muscle in health and disease
    Robert R Wolfe
    University of Texas Medical Branch, Department of Surgery and Shriners Burns Hospital, Metabolism Unit, Galveston, TX 77550, USA
    Am J Clin Nutr 84:475-82. 2006

Research Grants

  1. Dietary Factors in Colon Cancer Prevention
    FRANK ALBERT SIMMEN; Fiscal Year: 2013
  2. DERMATITIS HERPETIFORMIS AND THE MUCOSAL IMMUNE RESPONSE
    Russell Hall; Fiscal Year: 2005
  3. INTESTINAL PEPTIDE HYDROLASES AND PEPTIDE TRANSPORT
    Young Kim; Fiscal Year: 2000
  4. INSECT STORAGE PROTEINS
    Michael Wells; Fiscal Year: 1992
  5. TEAR ABNORMALITIES IN NEUROLOGICAL DISEASES
    Patricia Coyle; Fiscal Year: 1990
  6. A Policy-Oriented History of Newborn Screening for PKU
    Diane Paul; Fiscal Year: 2006
  7. Mentored Patient-Oriented Research Career Development Award
    Naim Maalouf; Fiscal Year: 2009
  8. INFLUENCE OF NUTRITIONAL FACTORS ON SOMATOMEDIN ACTIVITY
    MINNIE ELDERS; Fiscal Year: 1980
  9. NUTRITIVE VALUE OF PROTEINS
    DAVID HEGSTED; Fiscal Year: 1980
  10. The Effects of Aging in Oral Tolerance
    Howard Weiner; Fiscal Year: 2009

Detail Information

Publications303 found, 100 shown here

  1. pmc Diets with high or low protein content and glycemic index for weight-loss maintenance
    Thomas Meinert Larsen
    Department of Human Nutrition, Faculty of Life Sciences, University of Copenhagen, Copenhagen, Denmark
    N Engl J Med 363:2102-13. 2010
    ..Studies of weight-control diets that are high in protein or low in glycemic index have reached varied conclusions, probably owing to the fact that the studies had insufficient power...
  2. pmc Major dietary protein sources and risk of coronary heart disease in women
    Adam M Bernstein
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Circulation 122:876-83. 2010
    ..Our objective was to examine the relation between foods that are major dietary protein sources and incident CHD...
  3. pmc Dietary protein recommendations and the prevention of sarcopenia
    Douglas Paddon-Jones
    Department of Physical Therapy, Division of Rehabilitation Sciences The University of Texas Medical Branch 301 University Blvd Galveston, Texas 77555 1144, USA
    Curr Opin Clin Nutr Metab Care 12:86-90. 2009
    ..To draw attention to recent work on the role of protein and the amount of protein needed with each meal to preserve skeletal muscle mass in ageing...
  4. ncbi Dietary patterns, meat intake, and the risk of type 2 diabetes in women
    Teresa T Fung
    Department of Nutrition, Simmons College, Boston, Mass 02115, USA
    Arch Intern Med 164:2235-40. 2004
    ..To examine the association between major dietary patterns and risk of type 2 diabetes mellitus in a cohort of women...
  5. ncbi Validation of a self-administered food-frequency questionnaire administered in the European Prospective Investigation into Cancer and Nutrition (EPIC) Study: comparison of energy, protein, and macronutrient intakes estimated with the doubly labeled water,
    A Kroke
    Departments of Epidemiology, Intervention Studies, and Nutritional Biochemistry and Physiology, German Institute of Human Nutrition, Potsdam Rehbruecke, Germany
    Am J Clin Nutr 70:439-47. 1999
    ..The validation of dietary assessment instruments is critical in the evaluation of diet as a chronic disease risk factor...
  6. pmc Protein intake and incident frailty in the Women's Health Initiative observational study
    Jeannette M Beasley
    Clinical Coordinating Center, Women s Health Initiative, Fred Hutchinson Cancer Research Center, Seattle, Washington 98101, USA
    J Am Geriatr Soc 58:1063-71. 2010
    ..To evaluate the association between protein intake and incident frailty...
  7. ncbi Effects of protein, monounsaturated fat, and carbohydrate intake on blood pressure and serum lipids: results of the OmniHeart randomized trial
    Lawrence J Appel
    Welch Center for Prevention, Epidemiology and Clinical Research, Division of General Internal Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205 2223, USA
    JAMA 294:2455-64. 2005
    ..Reduced intake of saturated fat is widely recommended for prevention of cardiovascular disease. The type of macronutrient that should replace saturated fat remains uncertain...
  8. ncbi Limited and excess dietary protein during gestation affects growth and compositional traits in gilts and impairs offspring fetal growth
    C Rehfeldt
    Leibniz Institute for Farm Animal Biology, 18196 Dummerstorf, Germany
    J Anim Sci 89:329-41. 2011
    ....
  9. ncbi A long-term high-protein diet markedly reduces adipose tissue without major side effects in Wistar male rats
    Magali Lacroix
    Unité INRA 914 Physiologie de la Nutrition et Comportement Alimentaire, INA PG, 16 rue Claude Bernard, 75231 Paris Cedex 05, France
    Am J Physiol Regul Integr Comp Physiol 287:R934-42. 2004
    ..Our study suggests that the long-term consumption of an HP diet in male rats has no deleterious effects and could prevent metabolic syndrome...
  10. ncbi The underappreciated role of muscle in health and disease
    Robert R Wolfe
    University of Texas Medical Branch, Department of Surgery and Shriners Burns Hospital, Metabolism Unit, Galveston, TX 77550, USA
    Am J Clin Nutr 84:475-82. 2006
    ....
  11. ncbi Muscle full effect after oral protein: time-dependent concordance and discordance between human muscle protein synthesis and mTORC1 signaling
    Philip J Atherton
    School of Graduate Entry Medicine and Health, Division of Clinical Physiology, University of Nottingham, Royal Derby Hospital, Derby, United Kingdom
    Am J Clin Nutr 92:1080-8. 2010
    ..We previously showed that human muscle protein synthesis (MPS) increased during infusion of amino acids (AAs) and peaked at ≈120 min before returning to baseline rates, despite elevated plasma AA concentrations...
  12. pmc Nutritional status of Flemish vegetarians compared with non-vegetarians: a matched samples study
    Peter Deriemaeker
    Department of Human Biometry and Biomechanics, Faculty of Physical Education and Physical Therapy, Vrije Universiteit Brussel, Pleinlaan 2, B 1050 Brussel, Belgium Email K A M H P C
    Nutrients 2:770-80. 2010
    ..The intakes of the V subjects were closer to the recommendations for a healthy diet when compared to a group of well matched NV subjects...
  13. pmc Dietary intake of total, animal, and vegetable protein and risk of type 2 diabetes in the European Prospective Investigation into Cancer and Nutrition (EPIC)-NL study
    Ivonne Sluijs
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherland
    Diabetes Care 33:43-8. 2010
    ....
  14. pmc Dietary protein restriction of pregnant rats in the F0 generation induces altered methylation of hepatic gene promoters in the adult male offspring in the F1 and F2 generations
    Graham C Burdge
    Developmental Origins of Health and Disease Division, University of Southampton, Southampton, UK
    Br J Nutr 97:435-9. 2007
    ..This may represent a mechanism for the transmission of induced phenotypes between generations..
  15. pmc Leucine supplementation chronically improves muscle protein synthesis in older adults consuming the RDA for protein
    Shanon L Casperson
    Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX 77555, USA
    Clin Nutr 31:512-9. 2012
    ..Protein-energy supplementation is routinely employed to combat muscle loss. However, success is often compromised by increased satiety, poor palatability, high costs and low compliance...
  16. ncbi Obesity and the metabolic syndrome: role of different dietary macronutrient distribution patterns and specific nutritional components on weight loss and maintenance
    Itziar Abete
    Department of Nutrition, Food Science, Physiology and Toxicology, University of Navarra, Pamplona, Navarra, Spain
    Nutr Rev 68:214-31. 2010
    ....
  17. ncbi Dietary fat and meat intake in relation to risk of type 2 diabetes in men
    Rob M van Dam
    Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Diabetes Care 25:417-24. 2002
    ..To examine dietary fat and meat intake in relation to risk of type 2 diabetes...
  18. ncbi Dietary reference intakes for energy, carbohydrate, fiber, fat, fatty acids, cholesterol, protein and amino acids
    Paula Trumbo
    Food and Nutrition Board, Institute of Medicine, The National Academies, Washington, DC 20001, USA
    J Am Diet Assoc 102:1621-30. 2002
  19. ncbi Using intake biomarkers to evaluate the extent of dietary misreporting in a large sample of adults: the OPEN study
    Amy F Subar
    Applied Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, MD, USA
    Am J Epidemiol 158:1-13. 2003
    ..There was little underreporting of the percentage of energy from protein for men or women. These findings have important implications for nutritional epidemiology and dietary surveillance...
  20. ncbi Effect of normal-fat diets, either medium or high in protein, on body weight in overweight subjects: a randomised 1-year trial
    A Due
    Department of Human Nutrition, Centre for Advanced Food Studies, The Royal Veterinary and Agricultural University, 1958 Frederiksberg C, Denmark
    Int J Obes Relat Metab Disord 28:1283-90. 2004
    ..We have previously reported that a fat-reduced high-protein diet had more favourable effects on body weight loss over 6 months than a medium-protein diet...
  21. ncbi A central role for neuronal AMP-activated protein kinase (AMPK) and mammalian target of rapamycin (mTOR) in high-protein diet-induced weight loss
    Eduardo R Ropelle
    Department of Internal Medicine, State University of Campinas UNICAMP, 13083 970, Campinas, Sao Paulo, Brazil
    Diabetes 57:594-605. 2008
    ..Here, we sought to determine whether the response of the AMPK and mTOR pathways could contribute to the molecular effects of an HPD...
  22. ncbi Effects of supplemented isoenergetic diets differing in cereal fiber and protein content on insulin sensitivity in overweight humans
    Martin O Weickert
    Department of Clinical Nutrition, German Institute of Human Nutrition, Potsdam Rehbruecke, Germany
    Am J Clin Nutr 94:459-71. 2011
    ....
  23. ncbi Dietary protein intake in community-dwelling, frail, and institutionalized elderly people: scope for improvement
    Michael Tieland
    Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands
    Eur J Nutr 51:173-9. 2012
    ..Therefore, we assessed dietary protein intake, distribution of protein intake throughout the day, and the use of protein-containing food sources in community-dwelling, frail, and institutionalized elderly people in the Netherlands...
  24. ncbi Role of dietary protein in the sarcopenia of aging
    Douglas Paddon-Jones
    Department of Physical Therapy, The University of Texas Medical Branch, Galveston, TX 77555 1144, USA
    Am J Clin Nutr 87:1562S-1566S. 2008
    ..However, renal function decreases with age, and high protein intake is contraindicated in individuals with renal disease. Assessment of renal function is recommended for older individuals before they adopt a higher-protein diet...
  25. ncbi Differential effects of macronutrient content in 2 energy-restricted diets on cardiovascular risk factors and adipose tissue cell size in moderately obese individuals: a randomized controlled trial
    Salwa W Rizkalla
    INSERM, U, Nutriomique team 7, Centre de Recherche des Cordeliers, UMR S, Paris, France
    Am J Clin Nutr 95:49-63. 2012
    ..The most effective and safe dietary approach for weight loss and its impact on the metabolic functions and morphology of adipose tissue remain unclear...
  26. pmc Effect of dietary protein content on weight gain, energy expenditure, and body composition during overeating: a randomized controlled trial
    George A Bray
    Pennington Biomedical Research Center, 6400 Perkins Rd, Baton Rouge, LA 70808, USA
    JAMA 307:47-55. 2012
    ..The role of diet composition in response to overeating and energy dissipation in humans is unclear...
  27. ncbi Intake of total, animal and plant proteins, and their food sources in 10 countries in the European Prospective Investigation into Cancer and Nutrition
    J Halkjaer
    Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark
    Eur J Clin Nutr 63:S16-36. 2009
    ..To describe dietary protein intakes and their food sources among 27 redefined centres in 10 countries participating in the European Prospective Investigation into Cancer and Nutrition (EPIC)...
  28. ncbi Low carbohydrate-high protein diet and mortality in a cohort of Swedish women
    P Lagiou
    Department of Hygiene and Epidemiology, University of Athens Medical School, Goudi, Athens, Greece
    J Intern Med 261:366-74. 2007
    ..We have evaluated the association of the frequently recommended low carbohydrate diets - usually characterized by concomitant increase in protein intake - with long-term mortality...
  29. pmc Intrauterine growth retarded progeny of pregnant sows fed high protein:low carbohydrate diet is related to metabolic energy deficit
    Cornelia C Metges
    Research Unit Nutritional Physiology Oskar Kellner, Leibniz Institute for Farm Animal Biology FBN, Dummerstorf, Germany
    PLoS ONE 7:e31390. 2012
    ....
  30. ncbi Critical role for peptide YY in protein-mediated satiation and body-weight regulation
    Rachel L Batterham
    Centre for Diabetes and Endocrinology, Department of Medicine, University College London, WC1E 6JJ, United Kingdom
    Cell Metab 4:223-33. 2006
    ..Our findings suggest that modulating the release of endogenous satiety factors, such as PYY, through alteration of specific diet constituents could provide a rational therapy for obesity...
  31. ncbi A moderate-protein diet produces sustained weight loss and long-term changes in body composition and blood lipids in obese adults
    Donald K Layman
    University of Illinois, Department of Food Science and Human Nutrition, Urbana, IL 61801, USA
    J Nutr 139:514-21. 2009
    ..01). The PRO diet was more effective for FM loss and body composition improvement during initial weight loss and long-term maintenance and produced sustained reductions in TAG and increases in HDL-C compared with the CHO diet...
  32. ncbi Dietary protein intake is associated with lean mass change in older, community-dwelling adults: the Health, Aging, and Body Composition (Health ABC) Study
    Denise K Houston
    Sticht Center on Aging, Wake Forest University School of Medicine, Winston Salem, NC 27157 1207, USA
    Am J Clin Nutr 87:150-5. 2008
    ..Dietary surveys suggest that many older, community-dwelling adults consume insufficient dietary protein, which may contribute to the age-related loss of lean mass (LM)...
  33. ncbi Postnatal malnutrition and growth retardation: an inevitable consequence of current recommendations in preterm infants?
    N E Embleton
    Special Care Baby Unit, Royal Victoria Infirmary, Newcastle upon Tyne, United Kingdom
    Pediatrics 107:270-3. 2001
    ..RDI are based on needs for maintenance and growth, with no provision to replace this deficit. We, therefore, hypothesized that postnatal malnutrition and growth retardation were inevitable in infants fed current RDI...
  34. ncbi Effect of a high-protein, high-monounsaturated fat weight loss diet on glycemic control and lipid levels in type 2 diabetes
    Barbara Parker
    CSIRO Health Sciences and Nutrition, Adelaide, Australia
    Diabetes Care 25:425-30. 2002
    ..To determine the effect of a high-protein (HP) weight loss diet compared with a lower-protein (LP) diet on fat and lean tissue and fasting and postprandial glucose and insulin concentrations...
  35. pmc Processed meat and colorectal cancer: a review of epidemiologic and experimental evidence
    Raphaëlle L Santarelli
    UMR1089 INRA ENVT Xénobiotiques, Universite de Toulouse, Ecole Nationale Veterinaire, Toulouse, France
    Nutr Cancer 60:131-44. 2008
    ..Nitrosation might increase the toxicity of heme in cured products. Solving this puzzle is a challenge that would permit to reduce cancer load by changing the processes rather than by banning processed meat...
  36. pmc Differential stimulation of myofibrillar and sarcoplasmic protein synthesis with protein ingestion at rest and after resistance exercise
    Daniel R Moore
    Exercise Metabolism Research Group, Department of Kinesiology, McMaster University, Hamilton, Ontario, Canada
    J Physiol 587:897-904. 2009
    ..These data highlight the importance of measuring the synthetic response of specific muscle protein fractions when examining the effects of exercise and nutrition...
  37. ncbi Dietary implications on mechanisms of sarcopenia: roles of protein, amino acids and antioxidants
    Jeong Su Kim
    Department of Nutrition, Food and Exercise Sciences, College of Human Sciences, The Florida State University, Tallahassee, FL 32306 1493, USA
    J Nutr Biochem 21:1-13. 2010
    ..To address this gap in extant knowledge, this review will examine the effects of protein, amino acid and/or antioxidant intake on sarcopenia both at rest and following resistance training exercise...
  38. ncbi Effects of a high-protein ketogenic diet on hunger, appetite, and weight loss in obese men feeding ad libitum
    Alexandra M Johnstone
    Division of Obesity and Metabolic Health and Biomathematics and Statistics Scotland, Rowett Research Institute, Aberdeen, United Kingdom
    Am J Clin Nutr 87:44-55. 2008
    ..Altering the macronutrient composition of the diet influences hunger and satiety. Studies have compared high- and low-protein diets, but there are few data on carbohydrate content and ketosis on motivation to eat and ad libitum intake...
  39. ncbi Role of dietary proteins and amino acids in the pathogenesis of insulin resistance
    Frederic Tremblay
    Department of Anatomy and Physiology and Lipid Research Unit, Laval University Hospital Research Center, Quebec, Canada
    Annu Rev Nutr 27:293-310. 2007
    b>Dietary proteins and amino acids are important modulators of glucose metabolism and insulin sensitivity...
  40. ncbi Gluconeogenesis and energy expenditure after a high-protein, carbohydrate-free diet
    Margriet A B Veldhorst
    NUTRIM School for Nutrition, Toxicology and Metabolism, Department of Human Biology, Maastricht University Medical Centre, Netherlands
    Am J Clin Nutr 90:519-26. 2009
    ..High-protein diets have been shown to increase energy expenditure (EE)...
  41. pmc Low-carbohydrate diets and all-cause and cause-specific mortality: two cohort studies
    Teresa T Fung
    Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Ann Intern Med 153:289-98. 2010
    ..Data on the long-term association between low-carbohydrate diets and mortality are sparse...
  42. ncbi Dose-dependent satiating effect of whey relative to casein or soy
    Margriet A B Veldhorst
    Department of Human Biology of the Nutrition, Toxicology Research Institute Maastricht, Maastricht University, P O Box 616, Maastricht 6200 MD, The Netherlands
    Physiol Behav 96:675-82. 2009
    ..The results suggest that a difference in appetite ratings between types of protein appears when certain amino acids are above and below particular threshold values...
  43. ncbi The Diet, Obesity and Genes (Diogenes) Dietary Study in eight European countries - a comprehensive design for long-term intervention
    T M Larsen
    Department of Human Nutrition, Faculty of Life Sciences, University of Copenhagen, Copenhagen, Denmark
    Obes Rev 11:76-91. 2010
    ..Despite major cultural and dietary regional differences in Europe, interventions addressing effects of dietary factors are feasible with a reasonable attrition...
  44. ncbi Lower protein in infant formula is associated with lower weight up to age 2 y: a randomized clinical trial
    Berthold Koletzko
    Dr von Hauner Children s Hospital, University of Munich Medical Centre, Munich, Germany
    Am J Clin Nutr 89:1836-45. 2009
    ..Protein intake during infancy was associated with rapid early weight gain and later obesity in observational studies...
  45. pmc Protecting muscle mass and function in older adults during bed rest
    Kirk L English
    Department of Physical Therapy, Division of Rehabilitation Sciences, The University of Texas Medical Branch, Galveston, Texas 77555 1144, USA
    Curr Opin Clin Nutr Metab Care 13:34-9. 2010
    ....
  46. pmc Novel locus including FGF21 is associated with dietary macronutrient intake
    Audrey Y Chu
    Division of Preventive Medicine, Brigham and Women s Hospital, Boston, MA, USA
    Hum Mol Genet 22:1895-902. 2013
    ..9 × 10(-9)). A cytokine involved in cellular metabolism, FGF21 is a potential susceptibility gene for obesity and type 2 diabetes. Our results highlight the potential of genetic variation for determining dietary macronutrient intake...
  47. pmc The addition of a protein-rich breakfast and its effects on acute appetite control and food intake in 'breakfast-skipping' adolescents
    H J Leidy
    Department of Dietetics and Nutrition, University of Kansas Medical Center KUMC, Kansas City, KS 66160, USA
    Int J Obes (Lond) 34:1125-33. 2010
    ..It is unclear whether the addition of breakfast, with emphasis on dietary protein, leads to better appetite and energy intake regulation in adolescents...
  48. pmc Effect of dietary protein supplementation on blood pressure: a randomized, controlled trial
    Jiang He
    Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA 70112, USA
    Circulation 124:589-95. 2011
    ..Observational studies have reported an inverse association between dietary protein intake and blood pressure (BP). We compared the effect of soy protein, milk protein, and carbohydrate supplementation on BP among healthy adults...
  49. pmc A moderate serving of high-quality protein maximally stimulates skeletal muscle protein synthesis in young and elderly subjects
    T Brock Symons
    Graduate Center for Gerontology, University of Kentucky, Lexington, USA
    J Am Diet Assoc 109:1582-6. 2009
    ..Ingestion of more than 30 g protein in a single meal does not further enhance the stimulation of muscle protein synthesis in young and elderly...
  50. ncbi Dietary protein causes a decline in the glomerular filtration rate of the remnant kidney mediated by metabolic acidosis and endothelin receptors
    S Phisitkul
    Department of Internal Medicine, Texas Tech University Health Sciences Center, Lubbock, Texas, USA
    Kidney Int 73:192-9. 2008
    ..Our study suggests that the casein-induced decline in GFR of the remnant kidney is mediated by metabolic acidosis through endothelin A receptors...
  51. ncbi Effect of proteins from different sources on body composition
    J A Gilbert
    Division of Kinesiology, Faculty of Medicine, Laval University, Canada
    Nutr Metab Cardiovasc Dis 21:B16-31. 2011
    ..Protein intake enhances energy expenditure, satiety and fat loss, but there is no clear evidence to indicate whether there is a difference in the effect dependent on the source of the protein, i.e. from animal or plant-based foods...
  52. ncbi Effects of moderate variations in macronutrient composition on weight loss and reduction in cardiovascular disease risk in obese, insulin-resistant adults
    Tracey McLaughlin
    Stanford University School of Medicine, Stanford, CA 94305, USA
    Am J Clin Nutr 84:813-21. 2006
    ..Obese, insulin-resistant persons are at risk of cardiovascular disease. How best to achieve both weight loss and clinical benefit in these persons is controversial, and recent reports questioned the superiority of low-fat diets...
  53. pmc The influence of carbohydrate-protein co-ingestion following endurance exercise on myofibrillar and mitochondrial protein synthesis
    Leigh Breen
    School of Sport and Exercise Sciences, University of Birmingham, Birmingham, UK
    J Physiol 589:4011-25. 2011
    ..These data indicate that the increase in myofibrillar MPS for C+P could, potentially, be mediated through p70S6K, downstream of mTOR, which in turn may suppress the rise in eEF2 on translation elongation...
  54. pmc Dietary protein sources and the risk of stroke in men and women
    Adam M Bernstein
    Wellness Institute of the Cleveland Clinic, 1950 Richmond Road TR2 203, Lyndhurst, OH 44124, USA
    Stroke 43:637-44. 2012
    ..Few dietary protein sources have been studied prospectively in relation to stroke. We examined the relation between foods that are major protein sources and risk of stroke...
  55. pmc Comparative effects of low-carbohydrate high-protein versus low-fat diets on the kidney
    Allon N Friedman
    Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Clin J Am Soc Nephrol 7:1103-11. 2012
    ..Concerns exist about deleterious renal effects of low-carbohydrate high-protein weight loss diets. This issue was addressed in a secondary analysis of a parallel randomized, controlled long-term trial...
  56. ncbi Consumption of fluid skim milk promotes greater muscle protein accretion after resistance exercise than does consumption of an isonitrogenous and isoenergetic soy-protein beverage
    Sarah B Wilkinson
    Exercise Metabolism Research Group, Department of Kinesiology, McMaster University, Hamilton, Canada
    Am J Clin Nutr 85:1031-40. 2007
    ..Proteins from different sources may differ in their ability to support muscle protein accretion because of different patterns of postprandial hyperaminoacidemia...
  57. ncbi Protein supplementation during resistance-type exercise training in the elderly
    Marika Leenders
    Top Institute Food and Nutrition, Wageningen, The Netherlands
    Med Sci Sports Exerc 45:542-52. 2013
    ..We assessed whether dietary protein supplementation can further augment the adaptive response to prolonged resistance-type exercise training in healthy elderly men and women...
  58. ncbi The metabolism of "surplus" amino acids
    David A Bender
    Division of Biosciences and Division of Medical Education, University College London, Gower St, London WC1E 6BT, UK
    Br J Nutr 108:S113-21. 2012
    ....
  59. pmc Is there a maximal anabolic response to protein intake with a meal?
    Nicolaas E Deutz
    Center for Translational Research in Aging and Longevity, Department of Health and Kinesiology, Texas A and M University, College Station, TX 77843 4253, USA
    Clin Nutr 32:309-13. 2013
    ..We conclude that there is no practical upper limit to the anabolic response to protein or amino acid intake in the context of a meal...
  60. pmc Neural responses to visual food stimuli after a normal vs. higher protein breakfast in breakfast-skipping teens: a pilot fMRI study
    Heather J Leidy
    Department of Dietetics and Nutrition, University of Kansas Medical Center, Kansas City, Kansas, USA
    Obesity (Silver Spring) 19:2019-25. 2011
    ..Due to the small sample size, caution is warranted when interpreting these preliminary findings...
  61. ncbi Postexercise carbohydrate-protein supplementation improves subsequent exercise performance and intracellular signaling for protein synthesis
    Lisa Ferguson-Stegall
    Exercise Physiology and Metabolism Laboratory, Department of Kinesiology, University of Texas at Austin, Austin, Texas, USA
    J Strength Cond Res 25:1210-24. 2011
    ..7 vs. 69.2 ± 5.5%, p ≤ 0.05). These results indicate that postexercise CM supplementation can improve subsequent exercise performance and provide a greater intracellular signaling stimulus for PRO synthesis compared to CHO and placebo...
  62. ncbi Protein intake during gestation affects postnatal bovine skeletal muscle growth and relative expression of IGF1, IGF1R, IGF2 and IGF2R
    G C Micke
    School of Veterinary Science, The University of Queensland, St Lucia, QLD 4072, Australia
    Mol Cell Endocrinol 332:234-41. 2011
    ..Changes to expression of IGF genes in progeny skeletal muscle resulting from variations to maternal protein intake during gestation may have permanent and sex-specific effect on postnatal skeletal muscle growth...
  63. ncbi Protein supplementation before and after exercise does not further augment skeletal muscle hypertrophy after resistance training in elderly men
    Lex B Verdijk
    Department of Human Movement Sciences, Nutrition and Toxicology Research Institute Maastricht NUTRIM, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, Netherlands
    Am J Clin Nutr 89:608-16. 2009
    ..Considerable discrepancy exists in the literature on the proposed benefits of protein supplementation on the adaptive response of skeletal muscle to resistance-type exercise training in the elderly...
  64. ncbi Urine nitrogen as a biomarker for the validation of dietary protein intake
    Sheila A Bingham
    Medical Research Council, Cambridge, UK
    J Nutr 133:921S-924S. 2003
    ..Other markers of dietary intake and intermediate risk markers may also be measured in the 24-h urine that is obtained...
  65. pmc Associations of gestational exposure to famine with energy balance and macronutrient density of the diet at age 58 years differ according to the reference population used
    Aryeh D Stein
    Rollins School of Public Health, Emory University, Atlanta, GA 30322, USA
    J Nutr 139:1555-61. 2009
    ..Associations were weak, differed by choice of control, and may reflect sampling variability or methodological differences. Persistent small energy imbalances could explain the increased weight of famine-exposed individuals...
  66. ncbi Dosing and efficacy of glutamine supplementation in human exercise and sport training
    Michael Gleeson
    School of Sport and Exercise Sciences, Loughborough University, Loughborough LE11 3TU England
    J Nutr 138:2045S-2049S. 2008
    ....
  67. ncbi High-protein, reduced-carbohydrate weight-loss diets promote metabolite profiles likely to be detrimental to colonic health
    Wendy R Russell
    Rowett Institute of Nutrition and Health, University of Aberdeen, Aberdeen, United Kingdom
    Am J Clin Nutr 93:1062-72. 2011
    ..However, the effect of such diets on microbiota-derived metabolites that influence colonic health has not been established...
  68. ncbi Biomarkers of meat intake and the application of nutrigenomics
    Lars O Dragsted
    Department of Human Nutrition, University of Copenhagen, 30 Rolighedsvej, DK 1958 Frederiksberg C, Denmark
    Meat Sci 84:301-7. 2010
    ..Metabolomics by NMR spectroscopy of urine has also been applied to search for meat intake markers. Studies on single compounds or metabolomics markers are shortly reviewed here...
  69. ncbi Exercising before protein intake allows for greater use of dietary protein-derived amino acids for de novo muscle protein synthesis in both young and elderly men
    Bart Pennings
    Top Institute Food and Nutrition, Wageningen, Netherlands
    Am J Clin Nutr 93:322-31. 2011
    ..This blunted response could be the result of impaired protein digestion and absorption kinetics and lead to lower postprandial plasma amino acid availability...
  70. ncbi A diet high in protein, dairy, and calcium attenuates bone loss over twelve months of weight loss and maintenance relative to a conventional high-carbohydrate diet in adults
    Matthew P Thorpe
    Division of Nutritional Sciences, University of Illinois, Urbana Champaign, Urbana, IL 61801, USA
    J Nutr 138:1096-100. 2008
    ..4 g.kg(-1).d(-1) protein and 3 dairy servings increased urinary calcium excretion but provided improved calcium intake and attenuated bone loss over 4 mo of weight loss and 8 additional mo of weight maintenance...
  71. ncbi Maternal consumption of high-prebiotic fibre or -protein diets during pregnancy and lactation differentially influences satiety hormones and expression of genes involved in glucose and lipid metabolism in offspring in rats
    Alannah D Maurer
    Faculty of Kinesiology, University of Calgary, 2500 University Drive NW, Calgary, AB, Canada T2N 1N4
    Br J Nutr 105:329-38. 2011
    ..These early changes could have long-term consequences for obesity risk...
  72. pmc Reduced body weight and adiposity with a high-protein diet improves functional status, lipid profiles, glycemic control, and quality of life in patients with heart failure: a feasibility study
    Lorraine S Evangelista
    School of Nursing, University of California, Los Angeles, CA 90095 6918, USA
    J Cardiovasc Nurs 24:207-15. 2009
    ..The effectiveness of high-protein (HP) diets in reducing body weight and adiposity and potentially improving clinical outcomes in heart failure (HF) is not known...
  73. ncbi Limited and excess protein intake of pregnant gilts differently affects body composition and cellularity of skeletal muscle and subcutaneous adipose tissue of newborn and weanling piglets
    Charlotte Rehfeldt
    Research Unit Muscle Biology and Growth, Leibniz Institute for Farm Animal Biology, Wilhelm Stahl Allee 2, Dummerstorf, Germany
    Eur J Nutr 51:151-65. 2012
    ....
  74. ncbi Coingestion of protein with carbohydrate during recovery from endurance exercise stimulates skeletal muscle protein synthesis in humans
    Krista R Howarth
    Exercise Metabolism Research Group, Department of Kinesiology, McMaster University, Hamilton, Ontario, Canada
    J Appl Physiol (1985) 106:1394-402. 2009
    ..However, adding protein or additional CHO to a feeding strategy that provided 1.2 g CHO x kg(-1) x h(-1) did not further enhance glycogen resynthesis during recovery...
  75. ncbi The effects of high protein diets on thermogenesis, satiety and weight loss: a critical review
    Thomas L Halton
    Dept of Nutrition, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115, USA
    J Am Coll Nutr 23:373-85. 2004
    ..Although recent evidence supports potential benefit, rigorous longer-term studies are needed to investigate the effects of high protein diets on weight loss and weight maintenance...
  76. ncbi Short-term, increasing dietary protein and fat moderately affect energy expenditure, substrate oxidation and uncoupling protein gene expression in rats
    Klaus J Petzke
    Groups of Stable Isotopes and of Energy Metabolism, German Institute of Human Nutrition in Potsdam Rehbrücke DIfE, D 14558 Nuthetal, Germany
    J Nutr Biochem 18:400-7. 2007
    ..A function of UCPs in energy balance and dissipating food energy was suggested. Future experiments are focused on the regulation of UCP gene expression by dietary protein, which could be important for body-weight management...
  77. ncbi A high-protein, high-fat, carbohydrate-free diet reduces energy intake, hepatic lipogenesis, and adiposity in rats
    Lisa Pichon
    UMR INRA 914 Physiologie de la Nutrition et du Comportement Alimentaire, Institut National Agronomique Paris Grignon, F75231 Paris Cedex 05, France
    J Nutr 136:1256-60. 2006
    ..These reductions in adipose tissue development with decreases in the C:L ratio of the diet seemed to be due primarily to reduced hepatic lipogenesis...
  78. ncbi Diet-induced thermogenesis and substrate oxidation are not different between lean and obese women after two different isocaloric meals, one rich in protein and one rich in fat
    Nicholas Tentolouris
    1st Department of Propaedeutic Medicine, Athens University Medical School, Laiko Hospital, 115 23, Athens Greece
    Metabolism 57:313-20. 2008
    ..Over the long term, a low DIT after regular or frequent fat intake may contribute to the development and maintenance of obesity...
  79. ncbi Aging does not impair the anabolic response to a protein-rich meal
    T Brock Symons
    Division of Rehabilitation Sciences, The University of Texas Medical Branch, Galveston, TX 77555 1144, USA
    Am J Clin Nutr 86:451-6. 2007
    ..However, the ability of an actual protein-rich food to stimulate anabolism in the young and the elderly has not been explored...
  80. ncbi A crucial role of sterol regulatory element-binding protein-1 in the regulation of lipogenic gene expression by polyunsaturated fatty acids
    N Yahagi
    Department of Metabolic Diseases, Faculty of Medicine, University of Tokyo, Tokyo 113 8655, Japan
    J Biol Chem 274:35840-4. 1999
    ....
  81. ncbi Effects of variation in protein and carbohydrate intake on body mass and composition during energy restriction: a meta-regression 1
    James W Krieger
    Department of Food Science and Human Nutrition and of Statistics, University of Florida, Gainesville, FL 32611 0370, USA
    Am J Clin Nutr 83:260-74. 2006
    ..It is unclear whether low-carbohydrate, high-protein, weight-loss diets benefit body mass and composition beyond energy restriction alone...
  82. ncbi Postexercise muscle glycogen recovery enhanced with a carbohydrate-protein supplement
    John M Berardi
    Exercise Nutrition Research Laboratory, Faculty of Health Sciences, School of Kinesiology, The University of Western Ontario, Ontario, Canada
    Med Sci Sports Exerc 38:1106-13. 2006
    ....
  83. ncbi Differential effects of casein versus whey on fasting plasma levels of insulin, IGF-1 and IGF-1/IGFBP-3: results from a randomized 7-day supplementation study in prepubertal boys
    C Hoppe
    Department of Human Nutrition, Faculty of Life Sciences, University of Copenhagen, Frederiksberg, Denmark
    Eur J Clin Nutr 63:1076-83. 2009
    ..Milk increases both fasting insulin and insulin-like growth factor 1 (IGF-1), and thereby growth, in healthy prepubertal boys. It is, however, unknown which components in milk are responsible for milk's growth-stimulating effect...
  84. ncbi Plasma insulin responses after ingestion of different amino acid or protein mixtures with carbohydrate
    L J van Loon
    Nutrition and Toxicology Research Institute Maastricht NUTRIM, Department of Human Biology, Maastricht University, Maastricht, The Netherlands
    Am J Clin Nutr 72:96-105. 2000
    ..However, the insulinotropic properties of different amino acids or protein (hydrolysates) when co-ingested with carbohydrate have not been investigated...
  85. ncbi Effect of a chicken-based diet on renal function and lipid profile in patients with type 2 diabetes: a randomized crossover trial
    Jorge L Gross
    Endocrine Division, Hospital de Clinicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
    Diabetes Care 25:645-51. 2002
    ..To assess the effect of replacing red meat with chicken in the usual diet and the effect of a low-protein diet on glomerular filtration rate (GFR), urinary albumin excretion rate (UAER), and lipid levels in patients with type 2 diabetes...
  86. ncbi Low-carbohydrate-high-protein diet and long-term survival in a general population cohort
    A Trichopoulou
    Department of Hygiene and Epidemiology, School of Medicine, University of Athens, Athens, Greece
    Eur J Clin Nutr 61:575-81. 2007
    ..We have evaluated the effects on mortality of habitual low carbohydrate-high-protein diets that are thought to contribute to weight control...
  87. ncbi One-year weight maintenance after significant weight loss in healthy overweight and obese subjects: does diet composition matter?
    Elizabeth A Delbridge
    Department of Medicine, Heidelberg Repatriation Hospital, Heidelberg, Australia
    Am J Clin Nutr 90:1203-14. 2009
    ..Furthermore, the literature lacks consensus on the long-term effects of an HP diet on cardiovascular disease risk factors...
  88. ncbi A comparison of nutrient regulation between solitarious and gregarious phases of the specialist caterpillar, Spodoptera exempta (Walker)
    Kwang Pum Lee
    Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, UK
    J Insect Physiol 50:1171-80. 2004
    ..These phase-associated nutritional differences are consistent with the life-history strategies of the two phases...
  89. ncbi Physiopathological mechanism of sarcopenia
    Y Boirie
    Human Nutrition Unit, Clinical Nutrition Department, Human Nutrition Research Center of Auvergne, Clermont Ferrand, France
    J Nutr Health Aging 13:717-23. 2009
    ..Thus a multimodal approach combining nutrition, exercise, hormones, specific anabolic drugs may an innovative treatment for limiting the development of sarcopenia with aging...
  90. ncbi The effect of a high-protein, low glycemic-load diet versus a conventional, high glycemic-load diet on biochemical parameters associated with acne vulgaris: a randomized, investigator-masked, controlled trial
    Robyn N Smith
    School of Applied Sciences, RMIT University, Melbourne, Victoria, Australia
    J Am Acad Dermatol 57:247-56. 2007
    ..No previous study has sought to examine the influence of dietary composition on acne vulgaris...
  91. ncbi An adaptive metabolic demand model for protein and amino acid requirements
    D J Millward
    Centre for Nutrition and Food Safety, School of Biomedical and Molecular Sciences, University of Surrey, Guildford GU2 7XH, Surrey, UK
    Br J Nutr 90:249-60. 2003
    ..However, from a diagnostic perspective, indicators other than N balance need to be identified, since maintenance of N balance can no longer be used as a surrogate of adequate protein-related health...
  92. ncbi Low-carbohydrate-diet score and the risk of coronary heart disease in women
    Thomas L Halton
    Departments of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    N Engl J Med 355:1991-2002. 2006
    ..Low-carbohydrate diets have been advocated for weight loss and to prevent obesity, but the long-term safety of these diets has not been determined...
  93. ncbi Mediterranean and carbohydrate-restricted diets and mortality among elderly men: a cohort study in Sweden
    Per Sjogren
    Department of Public Health and Caring Sciences, Section of Clinical Nutrition and Metabolism, Uppsala University, Uppsala, Sweden
    Am J Clin Nutr 92:967-74. 2010
    ..Comparative studies on dietary patterns and long-term mortality are sparse...
  94. ncbi Protein, weight management, and satiety
    Douglas Paddon-Jones
    Department of Physical Therapy, The University of Texas Medical Branch, Galveston, TX 77555 1144, USA
    Am J Clin Nutr 87:1558S-1561S. 2008
    ..Nevertheless, any potential benefits associated with a moderately elevated protein intake must be evaluated in the light of customary dietary practices and individual variability...
  95. ncbi Stimulation by food proteins plays a critical role in the maturation of the immune system
    Juscilene da Silva Menezes
    Departamento de Imunologia, Universidade de Sao Paulo, Av Prof Lineu Prestes 1730, Sao Paulo, SP 05508 900 Brazil
    Int Immunol 15:447-55. 2003
    ..In the present study, we replaced intact dietary proteins by equivalent amounts of amino acids from weaning on and investigated its effects on the development of the ..
  96. ncbi Oral nutritional supplements containing (n-3) polyunsaturated fatty acids affect the nutritional status of patients with stage III non-small cell lung cancer during multimodality treatment
    Barbara S van der Meij
    Department of Nutrition and Dietetics, Internal Medicine, VU University Medical Center, Amsterdam, The Netherlands
    J Nutr 140:1774-80. 2010
    ..03 and B = 25.0 g, P = 0.01, respectively). In conclusion, a protein- and energy-dense oral nutritional supplement containing (n-3) fatty acids beneficially affects nutritional status during multimodality treatment in patients with NSCLC...
  97. pmc Sex differences in transgenerational alterations of growth and metabolism in progeny (F2) of female offspring (F1) of rats fed a low protein diet during pregnancy and lactation
    E Zambrano
    Department of Reproductive Biology, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran Vasco de Quiroga 15, 14000, Mexico, DF Mexico
    J Physiol 566:225-36. 2005
    ....
  98. ncbi Maternal protein restriction with or without folic acid supplementation during pregnancy alters the hepatic transcriptome in adult male rats
    Karen A Lillycrop
    Development and Cell Biology, University of Southampton, Bassett Crescent East, Southampton, UK
    Br J Nutr 103:1711-9. 2010
    ..The present findings show that the pattern of induced changes in the adult liver transcriptome were dependent on maternal protein and folic acid intakes during pregnancy...
  99. ncbi Casein and whey exert different effects on plasma amino acid profiles, gastrointestinal hormone secretion and appetite
    W L Hall
    Centre for Nutrition and Food Safety, School of Biomedical and Life Sciences, University of Surrey, Guildford, Surrey GU2 7XH
    Br J Nutr 89:239-48. 2003
    ....
  100. ncbi Early macronutrient intake and overweight at five years of age
    S Scaglioni
    Department of Paediatrics, San Paolo Hospital, Milan, Italy
    Int J Obes Relat Metab Disord 24:777-81. 2000
    ..To examine the influence of the macronutrient intake in early life on the development of overweight in children...
  101. ncbi Prenatal high protein exposure decreases energy expenditure and increases adiposity in young rats
    Maren Daenzer
    Department Biochemistry and Physiology of Nutrition, German Institute of Human Nutrition, 14558 Bergholz Rehbrucke, Germany
    J Nutr 132:142-4. 2002
    ..05). Postnatal HP alone had no significant effect on body composition or metabolic rate. These results indicate that in utero exposure to a high protein level reprograms body weight and energy homeostasis...

Research Grants67

  1. Dietary Factors in Colon Cancer Prevention
    FRANK ALBERT SIMMEN; Fiscal Year: 2013
    ..Diets will contain equal amounts of casein (control protein) or soy protein isolate (SPI). These dietary proteins elicited significant differences in intestinal tumor indices after administration of the chemical carcinogen, ..
  2. DERMATITIS HERPETIFORMIS AND THE MUCOSAL IMMUNE RESPONSE
    Russell Hall; Fiscal Year: 2005
    ..will provide new information regarding factors that may modify and regulate the mucosal immune response to dietary proteins in man and how mucosal inflammation results in inflammatory disease in the skin, joints and other organs...
  3. INTESTINAL PEPTIDE HYDROLASES AND PEPTIDE TRANSPORT
    Young Kim; Fiscal Year: 2000
    ..define the molecular, biochemical and physiological mechanisms involved in the digestion and absorption of dietary proteins, peptides and amino acids in the mammalian small intestine...
  4. INSECT STORAGE PROTEINS
    Michael Wells; Fiscal Year: 1992
    Insects have evolved a system for storage of amino acids in which amino acids derived from dietary proteins during the last feeding larval stage are used to synthesize large amounts of a few well-defined proteins, called storage proteins...
  5. TEAR ABNORMALITIES IN NEUROLOGICAL DISEASES
    Patricia Coyle; Fiscal Year: 1990
    ..Mucosal integrity will be studies by looking for circulating Antigen-Ab complexes to normally excluded dietary proteins. The presence of viral specific immune complexes will be correlated with viral Ab in secretory fluids...
  6. A Policy-Oriented History of Newborn Screening for PKU
    Diane Paul; Fiscal Year: 2006
    ..with this rare inherited disease are unable to metabolize phenylalanine, an essential amino acid found in all dietary proteins. In the absence of treatment, ingested phenylalanine and its metabolites accumulate to toxic levels in blood ..
  7. Mentored Patient-Oriented Research Career Development Award
    Naim Maalouf; Fiscal Year: 2009
    ..Excessive intake of dietary proteins has long been known to significantly raise the urinary excretion of calcium, increasing the risk for kidney ..
  8. INFLUENCE OF NUTRITIONAL FACTORS ON SOMATOMEDIN ACTIVITY
    MINNIE ELDERS; Fiscal Year: 1980
    ..To perform these studies, we will study the effects of specific alterations of dietary proteins, fats, and carbohydrates on plasma growth hormone concentrations, somatomedin activity, growth rate, ..
  9. NUTRITIVE VALUE OF PROTEINS
    DAVID HEGSTED; Fiscal Year: 1980
    ..objective of these studies is to develop adequate methods for the evaluation of nutritional quality of dietary proteins. Specifically, it includes extension of the previously proposed method for the evaluation of the efficiency ..
  10. The Effects of Aging in Oral Tolerance
    Howard Weiner; Fiscal Year: 2009
    ..aging raises concern about possible allergic reactions in the older individuals upon oral exposure to novel dietary proteins. With the increasing number of elderly worldwide, studies on the impact of aging in these immune processes ..
  11. EXERCISE, LIPOLYSIS AND FAT OXIDATION
    Robert Wolfe; Fiscal Year: 2002
    ..abstract_text> ..
  12. Amino Acids and Muscle Protein Synthesis
    Robert Wolfe; Fiscal Year: 2006
    ..abstract_text> ..
  13. MUSCLE PROTEIN METABOLISM AND NUTRITION IN THE ELDERLY
    Robert Wolfe; Fiscal Year: 2002
    ..These studies will provide the metabolic basis for the formulation of a nutritional supplement that should optimally stimulate net muscle protein synthesis. ..
  14. EXERCISE EFFECTS ON PROTEIN METABOLISM
    Robert Wolfe; Fiscal Year: 2002
    ..The results of this study will also contribute to our understanding of the mechanism whereby nutritional intake affects muscle protein metabolism. ..
  15. DIETARY PROTEIN REQUIREMENTS OF ELDERLY MEN AND WOMEN
    WAYNE CAMPBELL; Fiscal Year: 2002
    ..The results of the study will contribute to our understanding of the metabolism and requirement for protein, and will be critical to establishing a RDA for protein of elderly people. ..
  16. Food Rheology and Exercise in Aging Humans
    WAYNE CAMPBELL; Fiscal Year: 2009
    ..abstract_text> ..
  17. Anti-Inflammatory and Anti-Oxidative Nutrition in Dialysis Patients
    Kamyar Kalantar Zadeh; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  18. Iron and the Breast-fed Infant
    Ekhard Ziegler; Fiscal Year: 2005
    ..We expect to find that infants re-excrete iron into the feces when their iron stores are full, but retain most of the absorbed iron when iron stores are low. ..
  19. EFFECTS OF EARLY AGGRESSIVE NUTRITION ON VLBW INFANTS
    Sudha Kashyap; Fiscal Year: 2005
    ....
  20. Nutritional/Inflammatory Evaluation of Dialysis Patients
    Kamyar Kalantar Zadeh; Fiscal Year: 2005
    ....
  21. Developing Educational Approaches for Mexican-Americans
    Julio Licinio; Fiscal Year: 2005
    ..Their input will also be incorporated into the article that will be submitted to a peer-reviewed journal. ..
  22. Prevention of Vitamin D Deficiency in Breastfed Infants
    Ekhard Ziegler; Fiscal Year: 2009
    ..The study has considerable public health importance because of the importance of preventing vitamin D deficiency not only in its severe form, rickets, but also in its milder forms. ..
  23. "MENTORED PATIENT-ORIENTED RESEARCH CAREER DEVELOPMENT AWARD"
    Allon Friedman; Fiscal Year: 2009
    ..abstract_text> ..
  24. Glutathione in Environmental Toxicity and Disease
    HOWARD SHERTZER; Fiscal Year: 2007
    ..Our proposed research should therefore help focus future genotype-phenotype association studies between the appropriate DNA variant sites in the GCLC and GCLM genes and disease. ..
  25. Age-related changes in glutathione synthesis
    NAOMI FUKAGAWA; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  26. ENDOCRINE EFFECTS OF HUMAN LEPTIN REPLACEMENT
    Julio Licinio; Fiscal Year: 2005
    ..Discontinuation of this study would be highly deleterious, not only for the patients, but also for our understanding of the long-term effects of leptin in humans. ..
  27. Identification of Biomarkers of Autoimmunity in T1D by Novel Tools
    Mikael Knip; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  28. Metabonomic Urine Analysis: The INTERMAP Diet-BP Study
    Jeremiah Stamler; Fiscal Year: 2003
    ..abstract_text> ..
  29. MECHANISMS OF HYPOALBUMINEMIA IN ENDSTAGE RENAL DISEASE
    George Kaysen; Fiscal Year: 2001
    ..We will further establish the effect of KT/V, dialyzer permeability and reuse on changes in albumin, nutritional status and acute phase response. ..
  30. RECEPTOR MEDIATED OXIDATIVE STRESS
    HOWARD SHERTZER; Fiscal Year: 2003
    ..These studies will improve our understanding of how PHAHs such as TCDD generate oxidative stress and mutagenesis, leading to better models for risk assessment and novel strategies for intervention in PHAH-mediated toxicity. ..
  31. EFFECT OF AGE AND GLYCEMIA ON TRANSCRIPTION FACTORS
    NAOMI FUKAGAWA; Fiscal Year: 2004
    ..abstract_text> ..
  32. UCLA GRADUATE TRAINING PROGRAM IN TRANSITIONAL INVESTIGA
    Julio Licinio; Fiscal Year: 2004
    ..abstract_text> ..
  33. Chaperones, ROS systems, & IGF-1:Roles in vascular aging
    David Clemmons; Fiscal Year: 2008
    ..abstract_text> ..
  34. Dysbiosis in Inflammatory Bowel Disease
    Ece Mutlu; Fiscal Year: 2008
    ..ALH may enable a real-time survey of microfloral changes for the first time in medicine and may provide the first evidence linking IBD with specific microbial patterns. [unreadable] [unreadable] [unreadable]..
  35. Tuberculosis Diagnostics: Towards More Precise Testing in Children
    Joseph Bellanti; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  36. IRON SUPPLEMENTS AND ZINC IN PREGNANCY AND LACTATION
    Janet King; Fiscal Year: 2001
    ..Results from this comprehensive, longitudinal study will provide new data on the effects of iron supplementation on zinc utilization during pregnancy and lactation. ..
  37. International Trace Elements Conference
    Janet King; Fiscal Year: 2002
    ..The purpose of this proposal is to seek funding for the travel of selected speakers, young investigator awards, and publication of the proceedings. ..
  38. Metabolic analysis in human sulfur amino acid deficiency
    Dean Jones; Fiscal Year: 2005
    ..g., 300 samples/day with a flow cell), results will show whether this approach could be useful for nutritional assessment of complex metabolic effects of SAA intake. ..
  39. RENAL MEDULLARY NITRIC OXIDE AND BLOOD PRESSURE
    David Mattson; Fiscal Year: 2001
    ....
  40. MATRIX GLA PROTEIN AND CARTILAGE CALCIFICATION
    Paul Price; Fiscal Year: 2001
    ..The investigators will further study the demonstrated ability of MGP to inhibit calcification in supersaturated solutions, and will investigate the ability of MGP to inhibit matrix vesicle -initiated calcification. ..
  41. KINETICS OF HUMAN POSTPRANDIAL LIPOPROTEIN METABOLISM
    Frank Sacks; Fiscal Year: 2001
    ..These studies will increase our understanding of the metabolic pathways that are activated or suppressed postprandially, and could lead to treatments for reducing the development of atherosclerosis. ..
  42. LA Health:Primary and Secondary Obesity Prevention
    Donald Williamson; Fiscal Year: 2009
    ..The results of this investigation will significantly impact public health policy related to obesity prevention in rural communities, minority communities, and in children from families that are economically disadvantaged. ..
  43. INCREASING SCHOOL SNACK BAR FRUIT AND VEGETABLE INTAKE
    Karen Cullen; Fiscal Year: 2001
    ..Positive findings from this study should be applicable to middle schools where snack bars are available. ..
  44. Understanding Disparities in Obesity and its Comorbidities in the US
    Youfa Wang; Fiscal Year: 2010
    ..S. using an interdisciplinary approach. ..
  45. Sulfur Amino Acid Metabolism in NAFLD
    Satish C Kalhan; Fiscal Year: 2010
    ..The proposed studies are aimed at examining the metabolic mechanisms involved in the progression of this disease, so that specific targeted intervention strategies related to the stage of the disease can be identified and evaluated. ..
  46. Role of Leptin in the Neuroendocrine Response to Fasting
    Christos S Mantzoros; Fiscal Year: 2011
    ..abstract_text> ..
  47. Obstructive Sleep Apnea (OSA) in obese teens & preteens: Neurobahavioral effects
    Dean Beebe; Fiscal Year: 2008
    ..abstract_text> ..
  48. Isoflavones:Acute Response in Chronic Renal Failure
    Paolo Fanti; Fiscal Year: 2002
    ..3. Intake of soy isoflavones suppresses NF-KB activity in peripheral blood monocytic cells of ESRD patients, in a manner consistent with change of cytokine levels and of clinical parameters of disease. ..
  49. Exploring strategies to increase school breakfast consumption in middle schools
    Karen Cullen; Fiscal Year: 2007
    ..Improving SB participation may be an important public health environmental intervention with both significant health and academic outcomes. [unreadable] [unreadable] [unreadable]..
  50. Dietary Glycemic Load, Body Weight, and Blood Lipids
    Yunsheng Ma; Fiscal Year: 2005
    ..abstract_text> ..
  51. Mechanisms of Sexual Dimorphism in Perinatal Programming
    LORI WOODS; Fiscal Year: 2005
    ..Renal renin-angiotensin system components will be measured in the neonatal period, and arterial pressure, renal function, and glomerular number and volume will be measured in juvenile and adult animals. ..
  52. Single Muscle Fiber Contractile Properties With Aging
    Scott Trappe; Fiscal Year: 2005
    ..With this information we will be able to determine, for the first time, the interaction of aging, resistance training, and gender on single muscle fiber contractile function. ..
  53. Renal and Hormonal Mechanisms of Perinatal Programming
    LORI WOODS; Fiscal Year: 2005
    ..Intrarenal RAS activity will be measured in fetal and newborn animals. Arterial pressure, renal function, and nephron number will be measured in chronically instrumented juvenile and adult offspring. ..
  54. Plant-Based Dietry Intervention in Type 2 Diabetes
    Neal Barnard; Fiscal Year: 2004
    ..Glycosylated hemoglobin, insulin concentrations, 24-hour urinary albumin, body weight, blood pressure, serum lipids, and related cardiovascular risk factors will be measured at baseline, 22 weeks, and 74 weeks. ..
  55. Genetic Polymorphisms Benign Prostatic Hyperplasia
    ROSEBUD ROBERTS; Fiscal Year: 2004
    ..This community-based cohort study should provide insights that should improve our understanding of the genetic control of hormonal mechanisms in the pathogenesis of BPH. ..
  56. Immunotherapy for Peanut Allergy
    ARVIL BURKS; Fiscal Year: 2007
    ..The significance of this proposal is that if peanut SLIT in peanut allergic patients is effective, the treatment would provide an immediate therapeutic option for patients. ..
  57. EXTRAMURAL RES FACILITIES CONSTR PROJ
    ARVIL BURKS; Fiscal Year: 2002
    ....
  58. Investigation of a Behavioral Substitute for Sunbathing
    Sherry Pagoto; Fiscal Year: 2007
    ..Prevention interventions that target high-risk segments of the community in settings where risk behavior occurs have potential for a large and focused public health impact. [unreadable] [unreadable] [unreadable]..
  59. Dietary Treatment of Crohn's Disease
    Ece Mutlu; Fiscal Year: 2007
    ..Significance. This study could provide information to suggest diet as a safe therapy for IBD and lay the groundwork for more definitive, randomized, controlled trials. ..
  60. Patient Oriented Research in Pediatric Nutrition
    Nancy Krebs; Fiscal Year: 2008
    ..abstract_text> ..
  61. Bone-Sparing by Ca Salts With & Without Extra Phosphorus
    Robert Heaney; Fiscal Year: 2008
    ..1 Description, ..
  62. International Medical Conference of Congenital Hyperinsulinism
    Charles Stanley; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  63. Genetic Epidemiology of Parkinson's Disease
    Karen Marder; Fiscal Year: 2008
    ..unreadable] [unreadable]..