glucocorticoid receptors

Summary

Summary: Cytoplasmic proteins that specifically bind glucocorticoids and mediate their cellular effects. The glucocorticoid receptor-glucocorticoid complex acts in the nucleus to induce transcription of DNA. Glucocorticoids were named for their actions on blood glucose concentration, but they have equally important effects on protein and fat metabolism. Cortisol is the most important example.

Top Publications

  1. ncbi Disruption of the glucocorticoid receptor gene in the nervous system results in reduced anxiety
    F Tronche
    Molecular Biology of the Cell I, Deutsches Krebsforschungzentrum, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Nat Genet 23:99-103. 1999
  2. ncbi Antiinflammatory action of glucocorticoids--new mechanisms for old drugs
    Turk Rhen
    Department of Biology, University of North Dakota, Grand Forks, USA
    N Engl J Med 353:1711-23. 2005
  3. ncbi Glucocorticoid receptors in major depression: relevance to pathophysiology and treatment
    C M Pariante
    Section of Clinical Neuropharmacology, Institute of Psychiatry, King's College London, London, United Kingdom
    Biol Psychiatry 49:391-404. 2001
  4. ncbi Mice with genetically altered glucocorticoid receptor expression show altered sensitivity for stress-induced depressive reactions
    Stephanie Ridder
    Division of Molecular Biology of the Cell I, German Cancer Research Center, D 69120 Heidelberg, Germany
    J Neurosci 25:6243-50. 2005
  5. ncbi Neuroendocrine regulation of immunity
    Jeanette I Webster
    Section on Neuroimmune Immunology and Behavior, National Institute of Mental Health, Bldg 36, Room 1A 23 MSC 4020, 36 Convent Drive, Bethesda, Maryland 20892 4020, USA
    Annu Rev Immunol 20:125-63. 2002
  6. pmc Analysis of binding reactions by fluorescence recovery after photobleaching
    Brian L Sprague
    Laboratory of Receptor Biology and Gene Expression, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
    Biophys J 86:3473-95. 2004
  7. pmc Mineralocorticoid receptors are indispensable for nongenomic modulation of hippocampal glutamate transmission by corticosterone
    Henk Karst
    Swammerdam Institute for Life Sciences, Center for Neurosciences SILS CNS, University of Amsterdam, Kruislaan 320, 1098 SM Amsterdam, The Netherlands
    Proc Natl Acad Sci U S A 102:19204-7. 2005
  8. ncbi Targeted disruption of the glucocorticoid receptor gene blocks adrenergic chromaffin cell development and severely retards lung maturation
    T J Cole
    Division of Molecular Biology of the Cell I, German Cancer Research Center, Heidelberg
    Genes Dev 9:1608-21. 1995
  9. pmc Physical association and functional antagonism between the p65 subunit of transcription factor NF-kappa B and the glucocorticoid receptor
    A Ray
    Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520
    Proc Natl Acad Sci U S A 91:752-6. 1994
  10. ncbi Cloning of human mineralocorticoid receptor complementary DNA: structural and functional kinship with the glucocorticoid receptor
    J L Arriza
    Science 237:268-75. 1987

Research Grants

  1. Steroid Responsive Mechanisms in the Ear
    DENNIS ROYAL TRUNE; Fiscal Year: 2012
  2. Ethanol Regulation of Serum Glucocorticoid Kinase I
    BLAIR N COSTIN; Fiscal Year: 2012
  3. Chronic Stress and Abdominal Pain: Novel Mechanisms
    John W Wiley; Fiscal Year: 2013
  4. An Aldosterone-Endothelin Feedback Mechanism on Sodium Homeostasis
    Charles S Wingo; Fiscal Year: 2012
  5. Understanding Pain of Gastrointestinal Origin in Women that Serve in OEF/OIF
    Beverley Greenwood-Van Meerveld; Fiscal Year: 2013
  6. Preclinical drug trial in mouse models of inflammation
    Kanneboyina Nagaraju; Fiscal Year: 2011
  7. REGULATION OF GENE EXPRESSION BY DNA BINDING LIGANDS
    Peter B Dervan; Fiscal Year: 2013
  8. STRESS, ADRENAL STEROIDS AND THE BRAIN
    Bruce S McEwen; Fiscal Year: 2013
  9. Arsenic, Histone Modification, and Transcription
    LYNN SHELDON; Fiscal Year: 2009
  10. Preclinical drug trial in mouse models of inflammation
    Kanneboyina Nagaraju; Fiscal Year: 2013

Detail Information

Publications391 found, 100 shown here

  1. ncbi Disruption of the glucocorticoid receptor gene in the nervous system results in reduced anxiety
    F Tronche
    Molecular Biology of the Cell I, Deutsches Krebsforschungzentrum, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Nat Genet 23:99-103. 1999
    ..Conditional mutagenesis of Gr in the nervous system provides genetic evidence for the importance of Gr signalling in emotional behaviour because mutant animals show an impaired behavioural response to stress and display reduced anxiety...
  2. ncbi Antiinflammatory action of glucocorticoids--new mechanisms for old drugs
    Turk Rhen
    Department of Biology, University of North Dakota, Grand Forks, USA
    N Engl J Med 353:1711-23. 2005
  3. ncbi Glucocorticoid receptors in major depression: relevance to pathophysiology and treatment
    C M Pariante
    Section of Clinical Neuropharmacology, Institute of Psychiatry, King's College London, London, United Kingdom
    Biol Psychiatry 49:391-404. 2001
    ..Further elucidation of the biochemical and molecular mechanisms involved in GR changes in major depression is an exciting frontier that will no doubt lead to new insights into the pathophysiology and treatment of affective disorders...
  4. ncbi Mice with genetically altered glucocorticoid receptor expression show altered sensitivity for stress-induced depressive reactions
    Stephanie Ridder
    Division of Molecular Biology of the Cell I, German Cancer Research Center, D 69120 Heidelberg, Germany
    J Neurosci 25:6243-50. 2005
    ..As a first potential molecular correlate for such changes, we identified a downregulation of BDNF protein content in the hippocampus of GR+/- mice, which is in agreement with the so-called neurotrophin hypothesis of depression...
  5. ncbi Neuroendocrine regulation of immunity
    Jeanette I Webster
    Section on Neuroimmune Immunology and Behavior, National Institute of Mental Health, Bldg 36, Room 1A 23 MSC 4020, 36 Convent Drive, Bethesda, Maryland 20892 4020, USA
    Annu Rev Immunol 20:125-63. 2002
    ..Particular details are presented on the effects of interruptions of this regulatory loop at multiple levels in predisposition and expression of immune diseases and on mechanisms of glucocorticoid effects on immune cells and molecules...
  6. pmc Analysis of binding reactions by fluorescence recovery after photobleaching
    Brian L Sprague
    Laboratory of Receptor Biology and Gene Expression, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
    Biophys J 86:3473-95. 2004
    ..Overall our approach establishes a more general framework to assess the role of diffusion, the number of binding states, and the binding constants underlying a FRAP recovery...
  7. pmc Mineralocorticoid receptors are indispensable for nongenomic modulation of hippocampal glutamate transmission by corticosterone
    Henk Karst
    Swammerdam Institute for Life Sciences, Center for Neurosciences SILS CNS, University of Amsterdam, Kruislaan 320, 1098 SM Amsterdam, The Netherlands
    Proc Natl Acad Sci U S A 102:19204-7. 2005
    ..regulates responsive genes in the rodent hippocampus through nuclear mineralocorticoid and glucocorticoid receptors. Via this genomic pathway the hormone alters properties of hippocampal cells slowly and for a prolonged ..
  8. ncbi Targeted disruption of the glucocorticoid receptor gene blocks adrenergic chromaffin cell development and severely retards lung maturation
    T J Cole
    Division of Molecular Biology of the Cell I, German Cancer Research Center, Heidelberg
    Genes Dev 9:1608-21. 1995
    ....
  9. pmc Physical association and functional antagonism between the p65 subunit of transcription factor NF-kappa B and the glucocorticoid receptor
    A Ray
    Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520
    Proc Natl Acad Sci U S A 91:752-6. 1994
    ..These studies suggest that direct interactions between NF-kappa B and glucocorticoid receptor may partly account for the antiinflammatory properties of glucocorticoids in vivo...
  10. ncbi Cloning of human mineralocorticoid receptor complementary DNA: structural and functional kinship with the glucocorticoid receptor
    J L Arriza
    Science 237:268-75. 1987
    ....
  11. ncbi Primary structure and expression of a functional human glucocorticoid receptor cDNA
    S M Hollenberg
    Nature 318:635-41. 1985
    ..Pure radiolabelled glucocorticoid receptor, synthesized in vitro, is immunoreactive and possesses intrinsic steroid-binding activity characteristic of the native glucocorticoid receptor...
  12. ncbi The glucocorticoid receptor: rapid exchange with regulatory sites in living cells
    J G McNally
    Laboratory of Receptor Biology and Gene Expression, Building 41, Room B602, National Cancer Institute, Bethesda, MD 20892 5055, USA
    Science 287:1262-5. 2000
    ..Thus, the interaction of regulatory proteins with target sites in chromatin is a more dynamic process than previously believed...
  13. pmc Glucocorticoid receptor phosphorylation differentially affects target gene expression
    Weiwei Chen
    Department of Pharmacology, and the NYU Cancer Institute, NYU School of Medicine, 550 First Avenue, New York, New York 10016, USA
    Mol Endocrinol 22:1754-66. 2008
    ..Furthermore, the effect of GR S211 phosphorylation is gene specific and, in some cases, dependent upon the amount of activated receptor...
  14. ncbi Proteasome-mediated glucocorticoid receptor degradation restricts transcriptional signaling by glucocorticoids
    A D Wallace
    Molecular Endocrinology Group, Laboratory of Signal Transduction, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    J Biol Chem 276:42714-21. 2001
    ..Together these findings suggest a major role of the ubiquitin-proteasome pathway in regulating glucocorticoid receptor protein turnover, thereby providing a mechanism to terminate glucocorticoid responses...
  15. pmc Repression of inflammatory responses in the absence of DNA binding by the glucocorticoid receptor
    H M Reichardt
    Division of Molecular Biology, German Cancer Research Center, Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany
    EMBO J 20:7168-73. 2001
    ..The only defect of immune suppression detected so far concerns the induced apoptosis of thymocytes and T lymphocytes...
  16. pmc Macrophage glucocorticoid receptors regulate Toll-like receptor 4-mediated inflammatory responses by selective inhibition of p38 MAP kinase
    Sandip Bhattacharyya
    Departments of Pediatrics, Washington University School of Medicine, St Louis, MO 63110, USA
    Blood 109:4313-9. 2007
    ..Taken together, we identify p38 MAPK and its downstream targets as essential for GR-mediated immunosuppression in macrophages...
  17. pmc Cytokine-effects on glucocorticoid receptor function: relevance to glucocorticoid resistance and the pathophysiology and treatment of major depression
    Thaddeus W W Pace
    Department of Psychiatry and Behavioral Sciences, Winship Cancer Institute, Emory University School of Medicine, 101 Woodruff Cricle, Suite 4000, Atlanta, GA 30322, USA
    Brain Behav Immun 21:9-19. 2007
    ....
  18. pmc Target-specific utilization of transcriptional regulatory surfaces by the glucocorticoid receptor
    Inez Rogatsky
    Department of Cellular and Molecular Pharmacology, Genentech Hall, Room S574, University of California, 600 16th Street, San Francisco, CA 94143 2280, USA
    Proc Natl Acad Sci U S A 100:13845-50. 2003
    ..These findings have strong implications for the nature of gene response element signaling, the composition and structure of regulatory complexes, and the mechanisms of context-specific transcriptional regulation...
  19. ncbi The human glucocorticoid receptor: one gene, multiple proteins and diverse responses
    Junguo Zhou
    Molecular Endocrinology Group, The Laboratory of Signal Transduction, National Institute of Environmental Health Sciences NIEHS NIH, DHHS, 111 T W Alexander Drive, Research Triangle Park, NC 27709, USA
    Steroids 70:407-17. 2005
    ..We speculate that the composition and proportion of individual isoforms expressed in particular cellular contexts account for the diverse effects of glucocorticoid hormones...
  20. ncbi The N363S polymorphism of the glucocorticoid receptor: potential contribution to central obesity in men and lack of association with other risk factors for coronary heart disease and diabetes mellitus
    M G Dobson
    Department of Endocrinology, Medical School, and Queen Elizabeth Hospital, University of Newcastle, Newcastle upon Tyne NE2 4HH, United Kingdom
    J Clin Endocrinol Metab 86:2270-4. 2001
    ..The results of this study suggest that this GR polymorphism may contribute to central obesity in men. Further studies are required to elucidate the properties of GR(363S) at a molecular level...
  21. ncbi Estradiol inhibits glucocorticoid receptor expression and induces glucocorticoid resistance in MCF-7 human breast cancer cells
    A V Krishnan
    Division of Endocrinology, Department of Medicine, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 95305-5103, USA
    J Steroid Biochem Mol Biol 77:29-37. 2001
    ....
  22. pmc GRIP1, a novel mouse protein that serves as a transcriptional coactivator in yeast for the hormone binding domains of steroid receptors
    H Hong
    Department of Pathology, University of Southern California, Los Angeles, 90033, USA
    Proc Natl Acad Sci U S A 93:4948-52. 1996
    ..Thus, in yeast, GRIP1 can serve as a coactivator, potentiating the transactivation functions in steroid receptor HBDs, possibly by acting as a bridge between HBDs of the receptors and the basal transcription machinery...
  23. ncbi Genetic dissection of glucocorticoid receptor function in mice
    F Tronche
    Molecular Biology of the Cell I, Deutsches Krebsforschungzentrum, Im Neuenheimer Feld 280, 69120, Heidelberg, Federal Republic of Germany
    Curr Opin Genet Dev 8:532-8. 1998
    ..Recent gene-targeting studies in mice provide new insight into the role of GR in vivo and are helping decipher the molecular mechanisms underlying its actions...
  24. pmc Ligand-dependent interaction of the glucocorticoid receptor with p53 enhances their degradation by Hdm2
    S Sengupta
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, BP 163, 67404 Illkirch Cedex, France
    Genes Dev 15:2367-80. 2001
    ..The ubiquitylation of GR requires p53, the interaction of p53 with Hdm2, and E3 ligase activity of Hdm2. These results provide a mechanistic basis for GR and p53 acting as opposing forces in the decision between cell death and survival...
  25. ncbi Mechanisms of glucocorticoid signalling
    Onard J L M Schoneveld
    AMC Liver Center, Academic Medical Center, University of Amsterdam, Meibergdreef 69 71, 1105 BK, Amsterdam, The Netherlands
    Biochim Biophys Acta 1680:114-28. 2004
    ..We propose that the activating signal of a distal enhancer can be relayed onto the transcription-initiation complex by coupling elements located proximal to the promoter...
  26. ncbi Inhibition of glucocorticoid-induced apoptosis by targeting the major splice variants of BIM mRNA with small interfering RNA and short hairpin RNA
    Marc T Abrams
    Department of Biochemistry and Molecular Pharmacology, Thomas Jefferson University, 233 S 10th Street, Philadelphia, PA 19107, USA
    J Biol Chem 279:55809-17. 2004
    ..These results offer evidence that the induction of Bim by GC is a required event for the complete apoptotic response in pre-B ALL cells...
  27. ncbi Glucocorticoid receptor isoforms generate transcription specificity
    Nick Z Lu
    Molecular Endocrinology Group, Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, NIH DHHS, Research Triangle Park, NC 27709, USA
    Trends Cell Biol 16:301-7. 2006
    ..Here, we discuss a new molecular model potentially underlying tissue-specific glucocorticoid resistance and selectivity...
  28. ncbi The genomic structure of the human glucocorticoid receptor
    I J Encio
    Clinical Neurogenetics Branch, National Institute of Mental Health, Bethesda, Maryland 20892
    J Biol Chem 266:7182-8. 1991
    ..This comparison also permitted the prediction of the positions of the splice sites and the sizes of the putative exons in the human mineralocorticoid receptor...
  29. ncbi Genomic and nongenomic effects of glucocorticoids
    Cindy Stahn
    Department of Rheumatology and Clinical Immunology, Charite University Hospital, Berlin, Germany
    Nat Clin Pract Rheumatol 4:525-33. 2008
    ..and immunosuppressive effects of glucocorticoids are mediated primarily by the cytosolic glucocorticoid receptors. These receptors are members of the steroid hormone receptor family, a superfamily of ligand-inducible ..
  30. ncbi Structural determinants of a glucocorticoid receptor recognition element
    S K Nordeen
    Department of Pathology, University of Colorado Health Sciences Center, Denver 80262
    Mol Endocrinol 4:1866-73. 1990
    ..A further implication is that the DNA-binding domain of the glucocorticoid receptor is composed of distinct subdomains, which interact with the subelements of the recognition sequence...
  31. ncbi Novel insights into mechanisms of glucocorticoid action and the development of new glucocorticoid receptor ligands
    Mark Lowenberg
    Department of Gastroenterology and Hepatology, Academic Medical Center, Meibergdreef 9, NL 1105 AZ Amsterdam, The Netherlands
    Steroids 73:1025-9. 2008
    ..As a consequence, membrane-linked GC receptors might be a potential candidate target for GC therapy. The ultimate goal is to convert these molecular insights into new GC receptor modulators with an improved therapeutic index...
  32. ncbi Molecular determinants of glucocorticoid sensitivity and resistance in acute lymphoblastic leukemia
    W J E Tissing
    University Hospital Rotterdam Sophia Children s Hospital, Department of Paediatric Oncology Hematology, Rotterdam, The Netherlands
    Leukemia 17:17-25. 2003
    ....
  33. ncbi Separating transrepression and transactivation: a distressing divorce for the glucocorticoid receptor?
    Robert Newton
    Department of Cell Biology and Anatomy, Faculty of Medicine, University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta, Canada
    Mol Pharmacol 72:799-809. 2007
    ..Considerable care is therefore required to avoid loss of anti-inflammatory effectiveness in the development of novel transactivation-defective ligands of GR...
  34. ncbi The conformation of the glucocorticoid receptor af1/tau1 domain induced by osmolyte binds co-regulatory proteins
    R Kumar
    Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston, Texas 77555, USA
    J Biol Chem 276:18146-52. 2001
    ..These data indicate that TMAO induces a conformation in AF1/tau1 that is important for its interaction with certain co-regulatory proteins...
  35. ncbi Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1
    J C Yoon
    Dana Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 413:131-8. 2001
    ..These results implicate PGC-1 as a key modulator of hepatic gluconeogenesis and as a central target of the insulin-cAMP axis in liver...
  36. pmc Risk factors for development of depression and psychosis. Glucocorticoid receptors and pituitary implications for treatment with antidepressant and glucocorticoids
    Carmine M Pariante
    Sections of Perinatal Psychiatry and Stress, Psychiatry and Immunology, Division of Psychological Medicine and Psychiatry Institute of Psychiatry, King s College London, London, United Kingdom
    Ann N Y Acad Sci 1179:144-52. 2009
    ..the full impact of the high glucocorticoid levels is felt on the brain, through over-stimulation of the glucocorticoid receptors (GRs); indeed, normalizing these high levels leads to an improvement of mood in these patients...
  37. ncbi Glucocorticoid and mineralocorticoid receptor mRNA expression in squirrel monkey brain
    P D Patel
    Mental Health Research Institute, University of Michigan Medical Center, 3064 NSL, 1103 East Huron Street, Ann Arbor, MI 48104 1687, USA
    J Psychiatr Res 34:383-92. 2000
    ..Different subregional distributions and distinctive laminar patterns suggest specialized functions or coordinated interactions between GR and MR mediated functions in primate PFC...
  38. ncbi Identification of the BclI polymorphism in the glucocorticoid receptor gene: association with sensitivity to glucocorticoids in vivo and body mass index
    Elisabeth F C van Rossum
    Department of Internal Medicine, Erasmus Medical Center, Rotterdam The Netherlands
    Clin Endocrinol (Oxf) 59:585-92. 2003
    ....
  39. ncbi Localization of glucocorticoid receptors at postsynaptic membranes in the lateral amygdala
    L R Johnson
    NIMH Conte Center for the Neuroscience of Fear and Anxiety Center for Neural Science, 4 Washington Place, New York University, New York, NY 10003, USA
    Neuroscience 136:289-99. 2005
    ..released in high concentrations from the adrenal cortex during stressful experiences, bind to glucocorticoid receptors in nuclear and peri-nuclear sites in neuronal somata...
  40. ncbi The dominant negative activity of the human glucocorticoid receptor beta isoform. Specificity and mechanisms of action
    R H Oakley
    Laboratory of Signal Transduction, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    J Biol Chem 274:27857-66. 1999
    ..Taken together, our results suggest that formation of transcriptionally impaired hGRalpha-hGRbeta heterodimers is an important component of the mechanism responsible for the dominant negative activity of hGRbeta...
  41. pmc Central amygdala glucocorticoid receptor action promotes fear-associated CRH activation and conditioning
    Benedict J Kolber
    Department of Pediatrics, Washington University, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 105:12004-9. 2008
    ..into the molecular mechanisms and subregional specificity of fear conditioning, we disrupted type II glucocorticoid receptors (GRs) in the central nucleus of the amygdala (CeA) by delivering lentiviral vectors containing Cre-..
  42. ncbi The human glucocorticoid receptor beta isoform. Expression, biochemical properties, and putative function
    R H Oakley
    Laboratory of Integrative Biology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    J Biol Chem 271:9550-9. 1996
    ..Thus, hGRbeta potentially functions as a dominant negative inhibitor of hGRalpha activity...
  43. ncbi Central glucocorticoid receptors modulate the expression and function of spinal NMDA receptors after peripheral nerve injury
    Shuxing Wang
    Pain Research Group, Massachusetts General Hospital Pain Center, Department of Anesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Neurosci 25:488-95. 2005
    Central glucocorticoid receptors (GRs) and NMDA receptors (NMDARs) have been shown to play a significant role in the mechanisms of neuropathic pain after peripheral nerve injury; however, how central GRs and NMDARs interact in this ..
  44. pmc The glucocorticoid receptor and FOXO1 synergistically activate the skeletal muscle atrophy-associated MuRF1 gene
    David S Waddell
    Department of Neurobiology, Physiology, and Behavior, University of California, Davis, California 95616, USA
    Am J Physiol Endocrinol Metab 295:E785-97. 2008
    ..These findings present new insights into the role of the GR and FOXO family of transcription factors in the transcriptional regulation of the MuRF1 gene, a direct target of the GR in skeletal muscle...
  45. ncbi Chronic stress attenuates glucocorticoid negative feedback: involvement of the prefrontal cortex and hippocampus
    K Mizoguchi
    Pharmacology Department, Central Research Laboratories, Tsumura and Co, 3586 Yoshiwara, Ami Machi, Inashiki Gun, Ibaraki, 300 1192, Japan
    Neuroscience 119:887-97. 2003
    ..This disruption is thought to involve down-regulation of glucocorticoid receptors (GRs) in the feedback sites of the brain...
  46. ncbi Role of adrenal steroid mineralocorticoid and glucocorticoid receptors in long-term potentiation in the CA1 field of hippocampal slices
    C Pavlides
    Rockefeller University, New York, NY 10021, USA
    Brain Res 738:229-35. 1996
    ..The present results are in agreement with previous studies showing that elevations in corticosterone or an acute episode of experimentally induced stress in vivo causes a suppression in LTP in the hippocampal CA1 field, in vitro...
  47. ncbi The etiology of steroid cataract
    Eric R James
    Sanaria, Inc, Rockville, MD 20850, USA
    J Ocul Pharmacol Ther 23:403-20. 2007
    ....
  48. pmc The HIV-1 virion-associated protein vpr is a coactivator of the human glucocorticoid receptor
    T Kino
    Section on Pediatric Endocrinology, Developmental Endocrinology Branch, National Institute of Child Health and Human Development, Bethesda, MD 20892, USA
    J Exp Med 189:51-62. 1999
    ..The glucocorticoid coactivator activity of Vpr may contribute to increased tissue glucocorticoid sensitivity in the absence of hypercortisolism and to the pathogenesis of AIDS...
  49. ncbi The proinflammatory cytokine, interleukin-1alpha, reduces glucocorticoid receptor translocation and function
    C M Pariante
    Section of Clinical Neuropharmacology, Institute of Psychiatry, London, United Kingdom
    Endocrinology 140:4359-66. 1999
    ....
  50. ncbi The crystal structure of the estrogen receptor DNA-binding domain bound to DNA: how receptors discriminate between their response elements
    J W Schwabe
    Medical Research Council Laboratory of Molecular Biology, Cambridge, England
    Cell 75:567-78. 1993
    ..Since all nuclear hormone receptors recognize one or the other of these two consensus half site sequences, this recognition mechanism applies generally to the whole receptor family...
  51. ncbi Prenatal exposure to maternal depression, neonatal methylation of human glucocorticoid receptor gene (NR3C1) and infant cortisol stress responses
    Tim F Oberlander
    Department of Pediatrics, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada
    Epigenetics 3:97-106. 2008
    ....
  52. ncbi A transgenic model of visceral obesity and the metabolic syndrome
    H Masuzaki
    Division of Endocrinology and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, Boston, MA, 02215, USA
    Science 294:2166-70. 2001
    ..Increased adipocyte 11beta HSD-1 activity may be a common molecular etiology for visceral obesity and the metabolic syndrome...
  53. ncbi Corticosterone slowly enhances miniature excitatory postsynaptic current amplitude in mice CA1 hippocampal cells
    Henk Karst
    Center for Neuroscience, Swammerdam Institute for Life Sciences, University of Amsterdam, Kruislaan 320, 1098 SM Amsterdam, The Netherlands
    J Neurophysiol 94:3479-86. 2005
    ..These effects were mimicked by 100 nM RU 28362, a selective agonist for intracellular glucocorticoid receptors. Evoked AMPA responses at the single cell were significantly enhanced when measured 2-4 h after ..
  54. pmc Acute stress enhances glutamatergic transmission in prefrontal cortex and facilitates working memory
    Eunice Y Yuen
    Department of Physiology and Biophysics, State University of New York at Buffalo, School of Medicine and Biomedical Sciences, Buffalo, NY 14214, USA
    Proc Natl Acad Sci U S A 106:14075-9. 2009
    ..stressors in vivo cause a long-lasting potentiation of NMDAR- and AMPAR-mediated synaptic currents via glucocorticoid receptors (GRs) selectively in PFC pyramidal neurons...
  55. pmc Differential regulation of glucocorticoid receptor transcriptional activation via AF-1-associated proteins
    A B Hittelman
    Department of Microbiology and the Kaplan Comprehensive Cancer Center, NYU School of Medicine, 550 First Avenue, New York, NY 10016, USA
    EMBO J 18:5380-8. 1999
    ..These results suggest that DRIP150 and DRIP205 functionally link GR AF-1 and AF-2, and represent important mediators of GR transcriptional enhancement...
  56. ncbi Nuclear localisation of calreticulin in vivo is enhanced by its interaction with glucocorticoid receptors
    H L Roderick
    Department of Medical Biochemistry, University of Wales College of Medicine, Cardiff, UK
    FEBS Lett 405:181-5. 1997
    ..The higher levels of nuclear fluorescence in LM(TK-) and HeLa cells suggested that glucocorticoid receptors might enhance nuclear localisation of calreticulin...
  57. ncbi The role of DnaJ-like proteins in glucocorticoid receptor.hsp90 heterocomplex assembly by the reconstituted hsp90.p60.hsp70 foldosome complex
    K D Dittmar
    Department of Pharmacology, The University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    J Biol Chem 273:7358-66. 1998
    ..hsp90 heterocomplex assembled in reticulocyte lysate. We conclude that hsp40 is a component of the multiprotein hsp90-based chaperone system where it potentiates GR.hsp90 heterocomplex assembly...
  58. ncbi Glucocorticoids, metabolism and metabolic diseases
    Alexandros Vegiopoulos
    Molecular Metabolic Control, German Cancer Research Center Heidelberg, Germany
    Mol Cell Endocrinol 275:43-61. 2007
    ..Therefore, this review focuses on the role of the GC-GR axis for metabolic homeostasis and dysregulation, emphasizing tissue-specific functions of GCs in the control of energy metabolism...
  59. ncbi A new first step in activation of steroid receptors: hormone-induced switching of FKBP51 and FKBP52 immunophilins
    Todd H Davies
    Department of Pharmacology, Medical College of Ohio, Toledo, Ohio 43614, USA
    J Biol Chem 277:4597-600. 2002
    ....
  60. pmc The glucocorticoid receptor inhibits NFkappaB by interfering with serine-2 phosphorylation of the RNA polymerase II carboxy-terminal domain
    R M Nissen
    Departments of Cellular and Molecular Pharmacology, and Biochemistry and Biophysics, PIBS Biochemistry and Molecular Biology Program, University of California, San Francisco, San Francisco, California 94143 0450, USA
    Genes Dev 14:2314-29. 2000
    ..Remarkably, GR did not inhibit PIC assembly under repressing conditions, but rather interfered with phosphorylation of serine 2 of the pol II CTD...
  61. pmc Determinants of cell- and gene-specific transcriptional regulation by the glucocorticoid receptor
    Alex Yick Lun So
    Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, California, United States of America
    PLoS Genet 3:e94. 2007
    ..We conclude that GR occupancy is a primary determinant of glucocorticoid responsiveness in A549 cells and that core GR binding sequences as well as GRE architecture likely harbor gene-specific regulatory information...
  62. ncbi A polymorphism in the glucocorticoid receptor gene may be associated with and increased sensitivity to glucocorticoids in vivo
    N A Huizenga
    Department of Internal Medicine III, Dijkzigt University Hospital, Rotterdam, The Netherlands
    J Clin Endocrinol Metab 83:144-51. 1998
    ..Life-long exposure to the mutated allele may be accompanied by an increased BMI and a lowered BMD in the lumbar spine but does not affect blood pressure...
  63. ncbi The glucose-6-phosphatase catalytic subunit gene promoter contains both positive and negative glucocorticoid response elements
    Beth T Vander Kooi
    Department of Molecular Physiology and Biophysics, 761 PRB MRB II, Vanderbilt University Medical School, Nashville, TN 37232 0615, USA
    Mol Endocrinol 19:3001-22. 2005
    ..We hypothesize that targeted signaling to the negative accessory element within the GRU may provide tight regulation of the glucocorticoid stimulation...
  64. ncbi Heterodimerization of mineralocorticoid and glucocorticoid receptors at a novel negative response element of the 5-HT1A receptor gene
    X M Ou
    Neuroscience Research Institute, University of Ottawa, Ottawa, Ontario K1H 8M5, Canada
    J Biol Chem 276:14299-307. 2001
    ..These data represent the first identification of an nMRE/GRE and indicate that heterodimerization of MR and GR mediates direct corticosteroid-induced transrepression of the 5-HT1A receptor promoter...
  65. pmc Selective regulation of bone cell apoptosis by translational isoforms of the glucocorticoid receptor
    Nick Z Lu
    Molecular Endocrinology Group, Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA
    Mol Cell Biol 27:7143-60. 2007
    ..Together, these findings provide new evidence that translational glucocorticoid receptor isoforms can elicit distinct glucocorticoid responses and may be useful for the development of safe glucocorticoids with reduced side effects...
  66. ncbi The origin and functions of multiple human glucocorticoid receptor isoforms
    Nick Z Lu
    The Laboratory of Signal Transduction, Molecular Endocrinology Group, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, 111 Alexander Drive, Research Triangle Park, NC 27709, USA
    Ann N Y Acad Sci 1024:102-23. 2004
    ..Unchecked expression of some isoforms, for example hGRbeta, has been implicated in various diseases...
  67. ncbi Antenatal maternal stress and long-term effects on child neurodevelopment: how and why?
    Nicole M Talge
    Institute of Child Development, University of Minnesota, USA
    J Child Psychol Psychiatry 48:245-61. 2007
    ....
  68. pmc Molecular determinants of crosstalk between nuclear receptors and toll-like receptors
    Sumito Ogawa
    Department of Cellular and Molecular Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA
    Cell 122:707-21. 2005
    ..These findings reveal combinatorial control of homeostasis and immune responses by nuclear receptors and suggest new approaches for treatment of inflammatory diseases...
  69. ncbi Glucocorticoids engage different signal transduction pathways to induce apoptosis in thymocytes and mature T cells
    Dapeng Wang
    Molecular Immunology, Institute for Virology and Immunobiology, University of Wurzburg, Wurzburg, Germany
    J Immunol 176:1695-702. 2006
    ..Collectively, the apoptotic program induced by GCs comprises cell type-specific as well as common features...
  70. ncbi A plant-derived ligand favoring monomeric glucocorticoid receptor conformation with impaired transactivation potential attenuates collagen-induced arthritis
    Pieter Dewint
    Department of Rheumatology, Ghent University Hospital, De Pintelaan 185, Ghent, Belgium
    J Immunol 180:2608-15. 2008
    ..Therefore, we conclude that GR monomers are sufficient for inhibition of inflammation in vivo...
  71. ncbi The glucocorticoid agonist activities of mifepristone (RU486) and progesterone are dependent on glucocorticoid receptor levels but not on EC50 values
    Shimin Zhang
    Division of Molecular Pathobiology, Department of Environmental and Infectious Disease Sciences, American Registry of Pathology, Armed Forces Institute of Pathology, Washington, DC 20306, USA
    Steroids 72:600-8. 2007
    ..299 had no agonist activity under any condition. Taken together, these results suggest that the phenomenon of receptor concentration-dependence is a property of partial GR agonists in general...
  72. ncbi Glucocorticoid receptor action in beneficial and side effects of steroid therapy: lessons from conditional knockout mice
    Anna Kleiman
    Leibniz Institute for Age Research, Fritz Lipmann Institute, Group of Tissue specific Hormone Action, Beutenberg Str 11, D 07745 Jena, Germany
    Mol Cell Endocrinol 275:98-108. 2007
    ..Also side effects of GCs occur in these mice. Thus, depending on the process that is treated, SEGRA could be therapeutically more or less effective and not all side effects of steroid therapy may be reduced...
  73. ncbi Structure of the glucocorticoid receptor (NR3C1) gene 5' untranslated region: identification, and tissue distribution of multiple new human exon 1
    Jonathan D Turner
    Institute of Immunology, Laboratoire National de Santé, 20A rue Auguste Lumière, L 1011, Luxembourg
    J Mol Endocrinol 35:283-92. 2005
    ....
  74. ncbi Effects of glucocorticoids on the growth and chemosensitivity of carcinoma cells are heterogeneous and require high concentration of functional glucocorticoid receptors
    Yen Shen Lu
    Department of Oncology, National Taiwan University Hospital, Taipei 10016, Taiwan, China
    World J Gastroenterol 11:6373-80. 2005
    ..To determine how glucocorticoids (GCs) may affect the growth and chemosensitivity of common carcinoma cells...
  75. pmc Stress-induced changes in corticosteroid receptor expression in primate hippocampus and prefrontal cortex
    Paresh D Patel
    Department of Psychiatry, Molecular and Behavioral Neuroscience Institute, University of Michigan Medical Center, 5053 Biomedical Sciences Research Building, 109 Zina Pitcher Place, Ann Arbor, MI 48109 2200, USA
    Psychoneuroendocrinology 33:360-7. 2008
    ..053). These results provide new information on regional differences and the long-term effects of stress on MR and GR distributions in corticolimbic regions that control cognitive and neuroendocrine functions...
  76. ncbi Transcriptional regulation of CYP2C9 gene. Role of glucocorticoid receptor and constitutive androstane receptor
    Sabine Gerbal-Chaloin
    INSERM U128, IFR24, Campus CNRS, 1919 Route de Mende, 34293 Montpellier, France
    J Biol Chem 277:209-17. 2002
    ..CYP2C9 appears therefore to be a primary glucocorticoid-responsive gene, which in addition, may be induced by xenobiotics through CAR/pregnane X receptor activation...
  77. pmc Glucocorticoid receptor activation of the I kappa B alpha promoter within chromatin
    B J Deroo
    Department of Biochemistry, The University of Western Ontario, London, Ontario, N6A 4L6, Canada
    Mol Biol Cell 12:3365-74. 2001
    ..However, glucocorticoids may be required for transcription factor binding, because DNaseI footprinting studies suggested that regulatory factors bind to the promoter upon glucocorticoid treatment...
  78. ncbi Mineralocorticoid and glucocorticoid receptors inhibit UCP expression and function in brown adipocytes
    S Viengchareun
    INSERM U 478, , , 16 rue Henri Huchard, 75870 Paris, France
    Am J Physiol Endocrinol Metab 280:E640-9. 2001
    ..Our results demonstrate that MR and GR inhibit expression of UCP1 and UCP3, thus participating in the control of energy expenditure...
  79. ncbi Ligand-selective transactivation and transrepression via the glucocorticoid receptor: role of cofactor interaction
    Katharina Ronacher
    Department of Biochemistry, University of Stellenbosch, Private Bag X1, Matieland 7602, South Africa
    Mol Cell Endocrinol 299:219-31. 2009
    ....
  80. pmc At least three promoters direct expression of the mouse glucocorticoid receptor gene
    U Strahle
    Institute of Cell and Tumor Biology, German Cancer Research Center, Heidelberg
    Proc Natl Acad Sci U S A 89:6731-5. 1992
    ..In contrast to a conservation of exon-intron structure, differences in promoter organization suggest a divergence between the evolution of regulatory and coding regions among members of the steroid receptor super-family...
  81. pmc Molecular chaperones function as steroid receptor nuclear mobility factors
    Cem Elbi
    Laboratory of Receptor Biology and Gene Expression, Building 41, Room B602, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 5055, USA
    Proc Natl Acad Sci U S A 101:2876-81. 2004
    ..Thus, our results provide a description of soluble nuclear mobility factors and furthermore demonstrate a previously unrecognized role for molecular chaperones in the regulation of steroid receptor function within the nucleus...
  82. ncbi Nuclear export of glucocorticoid receptor is enhanced by c-Jun N-terminal kinase-mediated phosphorylation
    M Itoh
    First Department of Internal Medicine, Sapporo Medical University School of Medicine, Sapporo, 060 8543, Japan
    Mol Endocrinol 16:2382-92. 2002
    ..Taken together, these findings suggest that JNK-mediated phosphorylation of the GR-Ser226 enhances GR nuclear export and may contribute to termination of GR-mediated transcription...
  83. pmc Human glucocorticoid receptor beta binds RU-486 and is transcriptionally active
    Laura J Lewis-Tuffin
    Laboratory of Signal Transduciton, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Mol Cell Biol 27:2266-82. 2007
    ....
  84. ncbi Differences between brain structures in nuclear translocation and DNA binding of the glucocorticoid receptor during stress and the circadian cycle
    Pierre Kitchener
    INSERM U588, Laboratoire de Physiopathologie du Comportement, Universite Bordeaux 2, Domaine de Carreire, rue Camille Saint Saens, 33077 Bordeaux Cedex, France
    Eur J Neurosci 19:1837-46. 2004
    b>Glucocorticoid receptors (GRs) are transcription factors that, upon activation by glucocorticoids, translocate to the cell nucleus, and bind to specific response elements (GREs) in the promoter region of target genes...
  85. ncbi Regulation of hippocampal glucocorticoid receptor gene transcription and protein expression in vivo
    J P Herman
    Department of Anatomy and Neurobiology, University of Kentucky Medical Center, Lexington, Kentucky 40536 0084, USA
    J Neurosci 18:7462-73. 1998
    b>Glucocorticoid receptors (GRs) are glucocorticoid-activated transcription factors that modulate expression of a variety of neuronal genes...
  86. ncbi Modelling the glucocorticoid receptor and producing therapeutic agents with anti-inflammatory effects but reduced side-effects
    Andrew McMaster
    Endocrine Sciences Research Group, Room 3 903, Stopford Building, University of Manchester, Manchester M13 9PT, UK
    Exp Physiol 92:299-309. 2007
    ..Current efforts have identified several useful tool compounds, and further molecules are in development in several pharmaceutical companies...
  87. ncbi The interplay between the glucocorticoid receptor and nuclear factor-kappaB or activator protein-1: molecular mechanisms for gene repression
    Karolien De Bosscher
    Department of Molecular Biology, Ghent University, K L Ledeganckstraat 35, 9000 Gent, Belgium
    Endocr Rev 24:488-522. 2003
    ..The various molecular pathways proposed so far are discussed in more detail...
  88. ncbi Stable and specific binding of heat shock protein 90 by geldanamycin disrupts glucocorticoid receptor function in intact cells
    L Whitesell
    Department of Pediatrics, University of Arizona Health Sciences Center, Tucson 85724, USA
    Mol Endocrinol 10:705-12. 1996
    ....
  89. pmc The glucocorticoid receptor blocks P-TEFb recruitment by NFkappaB to effect promoter-specific transcriptional repression
    Hans F Luecke
    Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA 94107 2280, USA
    Genes Dev 19:1116-27. 2005
    ..Thus, GR accomplishes selective repression by targeting promoter-specific components of NFkappaB regulatory complexes...
  90. ncbi Rapid spinogenesis of pyramidal neurons induced by activation of glucocorticoid receptors in adult male rat hippocampus
    Yoshimasa Komatsuzaki
    School of Science and Technology, Meiji University, 1 1 1 Higasimita, Tama, Kawasaki, Kanagawa 214, Japan
    Biochem Biophys Res Commun 335:1002-7. 2005
    ..Western immunoblot analysis demonstrated the localization of classical type GR in Triton-insoluble synaptosomal fractions (enriched in postsynaptic membranes) from hippocampal slices, suggesting a possible action site of DEX at spines...
  91. ncbi Tissue glucocorticoid resistance/hypersensitivity syndromes
    Tomoshige Kino
    Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 1583, USA
    J Steroid Biochem Mol Biol 85:457-67. 2003
    ....
  92. ncbi CD4(+)CD8(+)TCR(low) thymocytes express low levels of glucocorticoid receptors while being sensitive to glucocorticoid-induced apoptosis
    G J Wiegers
    Institute for General and Experimental Pathology, Medical School, University of Innsbruck, Austria
    Eur J Immunol 31:2293-301. 2001
    ..The latter finding and the presence of a homogeneous distribution of GR in each thymocyte subset provides an experimental basis for the concept that GR can antagonize TCR-mediated signals at a constant rate relative to TCR expression...
  93. ncbi Folding of the glucocorticoid receptor by the reconstituted Hsp90-based chaperone machinery. The initial hsp90.p60.hsp70-dependent step is sufficient for creating the steroid binding conformation
    K D Dittmar
    Department of Pharmacology, The University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    J Biol Chem 272:13047-54. 1997
    ..Our data suggest that hsp90, hsp70, and p60 work together as a chaperone complex that possesses all of the folding/unfolding activity necessary to generate the high affinity steroid binding conformation of the receptor...
  94. pmc Stress impairs GABAergic network function in the hippocampus by activating nongenomic glucocorticoid receptors and affecting the integrity of the parvalbumin-expressing neuronal network
    Wen Hu
    Clinical Neurobiology Laboratory, German Primate Center, Leibniz Institute for Primate Research, Gottingen, Germany
    Neuropsychopharmacology 35:1693-707. 2010
    ..This stress-induced dysfunctional inhibitory network may in turn impair rhythmic oscillations and thus lead to cognitive deficits that are common in stress-related psychiatric disorders...
  95. ncbi Low-dose dexamethasone alleviates lipopolysaccharide-induced acute lung injury in rats and upregulates pulmonary glucocorticoid receptors
    Xiao Qiu Wang
    Department of Respiratory Medicine, Shanghai First People s Hospital of Shanghai Jiaotong University, Shanghai, China
    Respirology 13:772-80. 2008
    ..This study investigated the therapeutic effect of low-dose dexamethasone (Dex) on inflammation and fibrosis in LPS-induced ALI in rats and its influence on the expression of the pulmonary glucocorticoid receptor (GR)...
  96. ncbi Cross talk of signaling pathways in the regulation of the glucocorticoid receptor function
    Laura Davies
    The University of Manchester, Oxford Road, Manchester M13 9PT, UK
    Mol Endocrinol 22:1331-44. 2008
    ....
  97. ncbi The expression of CYP2B6, CYP2C9 and CYP3A4 genes: a tangle of networks of nuclear and steroid receptors
    J M Pascussi
    Institut National de la Santé et de la Recherche Médicale U128, IFR 24, Centre National de la Recherche Scientifique, 1919 Route de Mende, 34293 05, Montpellier, France
    Biochim Biophys Acta 1619:243-53. 2003
    ..Moreover, they influence mutually their relative expression. This review is focused on these different pathways controlling human CYP2B6, CYP2C9 and CYP3A4 gene expression, and the cross-talk between these pathways...
  98. ncbi The glucocorticoid receptor mediates the thymic epithelial cell-induced apoptosis of CD4+8+ thymic lymphoma cells
    Yael Zilberman
    Department of Pharmacology, Faculty of Dental Medicine Founded by the Alpha Omega Fraternity, Jerusalem, Israel
    Cell Immunol 227:12-23. 2004
    ..This is in line with the low levels of corticosterone secreted by TEC. Altogether, our data show that TEC eliminates DP thymic lymphoma cells in a GR-dependent manner and modulates the GC sensitivity of the surviving cells...
  99. pmc Acquired deficit of forebrain glucocorticoid receptor produces depression-like changes in adrenal axis regulation and behavior
    Maureen P Boyle
    Department of Pediatrics, Washington University, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 102:473-8. 2005
    ....
  100. ncbi Gene expression of mineralocorticoid and glucocorticoid receptors in the limbic system is related to type-2 like diabetes in leptin-resistant rats
    Olaf Jöhren
    Institute of Experimental and Clinical Pharmacology and Toxicology, University of Lubeck, Ratzeburger Allee 160, D 23538, Lubeck, Germany
    Brain Res 1184:160-7. 2007
    ..This dysregulation of the HPA axis may eventually lead, in combination with leptin resistance, to the development of diabetes in ZDF rats...
  101. ncbi Reversal of maternal programming of stress responses in adult offspring through methyl supplementation: altering epigenetic marking later in life
    Ian C G Weaver
    Douglas Hospital Research Center, Montreal, Quebec H4H 1R3, Canada
    J Neurosci 25:11045-54. 2005
    ..These results demonstrate that, despite the inherent stability of the epigenomic marks established early in life through behavioral programming, they are potentially reversible in the adult brain...

Research Grants71

  1. Steroid Responsive Mechanisms in the Ear
    DENNIS ROYAL TRUNE; Fiscal Year: 2012
    ..Of particular interest are immune suppression of inflammatory cytokines and related transcription factors compared to the regulation of ion transport pathways that control fluid homeostasis. ..
  2. Ethanol Regulation of Serum Glucocorticoid Kinase I
    BLAIR N COSTIN; Fiscal Year: 2012
    ..The work proposed here could shed light on molecular mechanisms underlying alcoholism and eventually have implications in the development of novel pharmacological agents for alcoholism or alcohol-related neurological disorders. ..
  3. Chronic Stress and Abdominal Pain: Novel Mechanisms
    John W Wiley; Fiscal Year: 2013
    ....
  4. An Aldosterone-Endothelin Feedback Mechanism on Sodium Homeostasis
    Charles S Wingo; Fiscal Year: 2012
    ..Importantly, these studies will lend understanding into a novel signaling pathway that may explain the role of aldosterone in the progression of cardiovascular and renal disease. ..
  5. Understanding Pain of Gastrointestinal Origin in Women that Serve in OEF/OIF
    Beverley Greenwood-Van Meerveld; Fiscal Year: 2013
    ..Moreover, we will examine whether rats exposed to ELS show altered behavioral responses to chronic stress in adulthood compared to age-matched controls ..
  6. Preclinical drug trial in mouse models of inflammation
    Kanneboyina Nagaraju; Fiscal Year: 2011
    ..This proposal will help to train a pool of talented young scientists to pursue mouse model research and accelerate development of therapies for inflammatory diseases. ..
  7. REGULATION OF GENE EXPRESSION BY DNA BINDING LIGANDS
    Peter B Dervan; Fiscal Year: 2013
    ..Thus the proposed research is relevant to NIH's mission that pertains to developing fundamental knowledge that will create new therapeutic targets for alleviating disease. ..
  8. STRESS, ADRENAL STEROIDS AND THE BRAIN
    Bruce S McEwen; Fiscal Year: 2013
    ....
  9. Arsenic, Histone Modification, and Transcription
    LYNN SHELDON; Fiscal Year: 2009
    ..abstract_text> ..
  10. Preclinical drug trial in mouse models of inflammation
    Kanneboyina Nagaraju; Fiscal Year: 2013
    ..This program will help the Candidate to train and develop scientists interested in drug development in academic settings. These efforts in the long term will help us to develop specific drugs for inflammatory diseases. ..
  11. Neuroendocrine Mechanisms and Therapeutics in an Animal Model of PTSD
    DAVID MARK DIAMOND; Fiscal Year: 2013
    ..levels and increased glucocorticoid negative feedback sensitivity, as well as changes in CRF levels and glucocorticoid receptors. We will evaluate whether our psychosocial stress regimen produces a PTSD-like phenotype in ..
  12. Interventions Against the Molecular Etiology of BMPR2-induced PAH
    James D West; Fiscal Year: 2013
    ..This study will clarify the early molecular etiology of BMPR2-induced PAH, as well as providing information about BMP regulation of inflammation with implications to a host of diseases. ..
  13. Epigenetic Changes in the Glucocorticoid Receptor Gene Due to Arsenic Exposure
    Andrea M Allan; Fiscal Year: 2013
    ..Our investigation will use a prenatal arsenic-exposed mouse model to explore the epigenetic changes to the expression of the glucocorticoid receptor gene. ..
  14. The Toxic Environment and the Epigenetics of Fetal Growth
    HEATHER HERSON BURRIS; Fiscal Year: 2013
    ....
  15. Fatty acid Control Obesity and the Metabolic Syndrome via TPR proteins
    Terry D Hinds; Fiscal Year: 2010
    ....
  16. Epigenic Control of ENaC Transcription and Sodium Transport
    Wenzheng Zhang; Fiscal Year: 2013
    ..by activating two distinct but similar types of NR (nuclear receptors): MR and GR (mineralocorticoid and glucocorticoid receptors). MR disruption in mouse leads to PHA-1 and animal death around day 10 after birth...
  17. NeuroMolecular consequences of adolescent binge drinking
    Toni R Pak; Fiscal Year: 2013
    ....
  18. Central Mechanisms Modulating Visceral Sensitivity
    Beverley Greenwood-Van Meerveld; Fiscal Year: 2013
    ..Specific Aims:- Under Specific Aim 1, we will attempt to identify the relative importance of amygdala glucocorticoid receptors (GR) and mineralocorticoid receptors (MR) in anxiety and visceral pain...
  19. Investigation of Nephrotic Syndrome
    LIONEL CLAUDIUS CLEMENT; Fiscal Year: 2013
    ..In Specific Aim 3, putative interactions of Angptl4 with apolipoproteins C-II (activator of lipoprotei lipase) and C-III, (inhibitor of lipoprotein lipase) on the surface of HDL will be studied. ..
  20. Identification of an Epigenetic Risk Marker for PTSD
    Rachel Yehuda; Fiscal Year: 2010
    ..e., pretraumatic) biologic marker that can ultimately be used in screening persons at increased risk for PTSD either before or immediately after they are exposed to trauma. ..
  21. REGULATION OF NF-KAPPA B
    INDER MOHAN VERMA; Fiscal Year: 2013
    ..We propose to study the molecular mechanism of inflammatory processes by studying the regulation of NF-?B a seminal molecule in the induction of inflammation. ..
  22. Biomarkers in HPA axis and inflammatory pathways for suicidal behavior in youth
    Nadine M Melhem; Fiscal Year: 2013
    ....
  23. Glucocorticoid Receptor and Lipid Homeostasis
    Jen Chywan Wang; Fiscal Year: 2013
    ..abstract_text> ..
  24. Mechanisms of comorbidity between epilepsy and depression
    Andrey M Mazarati; Fiscal Year: 2013
    ..upregulation or raphe 5-HT1A autoreceptors can be reversed by the protracted pharmacological blockade of glucocorticoid receptors on the level of dorsal raphe...
  25. Viral mechanisms of adipocyte dysfuntion: Role of Vpr.
    Ashok Balasubramanyam; Fiscal Year: 2012
    ..The goal of this project is to determine how a protein made by the HIV virus, termed Vpr, can cause chronic inflammation of fat cells and lead to these disorders. ..
  26. Role of PPAR-gamma in Smoking-induced COPD Progression and Steroid Resistance
    Raju C Reddy; Fiscal Year: 2013
    ..levels of histone deacetylase 2 (HDAC2), which is required for a major mechanism through which activated glucocorticoid receptors (GRs) block transcription of inflammation-related genes...
  27. Transcriptional and epigenomic control of adipose tissue development and function
    David J Steger; Fiscal Year: 2013
    ....
  28. Novel Therapeutics in PTSD: A Randomized Clinical Trial of Mifepristone
    Gerardo Villarreal; Fiscal Year: 2013
    ..Several measures of neuroendocrine functioning will also be obtained to explore the relationship of plasma cortisol and ACTH levels to clinical response and the time to addition of rescue medications. ..
  29. CD8+ T Cell Immunity to Cytomegalovirus
    Stanley R Riddell; Fiscal Year: 2013
    ....
  30. Mechanisms of Functional Recovery After Partial Nerve Injury
    Michael M Wang; Fiscal Year: 2012
    ..The drugs we will test are already available for the treatment of other disorders. Thus, these experiments may soon lead to development of new treatments to enhance neurological recovery after traumatic nerve injury. ..
  31. Functional Dissection of Glucocorticoid Action in Metabolic Disease
    Charles A Harris; Fiscal Year: 2012
    ..In addition, the proposed research could point to the use of "dissociated GCs", safer anti-inflammatory medications to treat the millions of patients afflicted with inflammatory diseases. ..
  32. Physiological reactivity to acute stress during pregnancy
    LISA MICHELLE CHRISTIAN; Fiscal Year: 2010
    ....
  33. Social Regulation of Gene Expression
    John T Cacioppo; Fiscal Year: 2013
    ..The proposed research therefore is designed to identify the specific biological mechanisms mediating these genomic effects. ..
  34. BDNF-Trk Signaling &Cytokines in Patients with Mood Disorders
    Ghanshyam N Pandey; Fiscal Year: 2013
    ..Specific Aim 3. We will determine the protein and mRNA expression of the glucocorticoid receptors GR and MR and the transcription factors GRE and NF:B in the neutrophils and lymphocytes of patients with ..
  35. Postnatal Serotonin Deficits in Behavioral Pathogenesis: A Novel Genetic Approach
    MEREDITH SORENSON WHITNEY; Fiscal Year: 2013
    ..This study will take advantage of my innovative approaches to determine the importance, specifically, of postnatal 5-HT in behaviors that are relevant to many stress-related mental health disorders. ..
  36. GR Impairment in Carconogenesis: Tumor Suppressor Role
    THOMAS SLAGA; Fiscal Year: 2009
    ..4) To analyze the effects of dissociated glucocorticoids on skin inflammation, keratinocyte proliferation, and on skin tumor development. ..
  37. Maternal Smoking: HPA and Epigenetic Pathways to Infant Neurobehavioral Deficits
    Laura R Stroud; Fiscal Year: 2013
    ..Results from the proposed study will elucidate the earliest biomarkers of risk from maternal smoking and may lead to the development of novel therapeutic targets to protect infants whose mothers continue to smoke. ..
  38. Childhood Maltreatment: Epigenetic Modulation of the Glucocorticoid Receptor
    AUDREY TYRKA; Fiscal Year: 2012
    ..This information may contribute to future treatment and prevention efforts for stress- related disorders. ..
  39. Epigenetic Markers For Development of Schizophrenia
    Alessandro Guidotti; Fiscal Year: 2013
    ..This proposed research is potentially a major step toward the identification of objective biomarkers capable of predicting conversion to psychosis in HRSK subjects. ..
  40. Social, Genetic Determinants of Blood Pressure in Underserved African Americans
    SANDRA MARIE COULON; Fiscal Year: 2013
    ....
  41. Metabolic Impact of Fetal or Adult Exposure to Environmental Endocrine Disruptors
    Robert M Sargis; Fiscal Year: 2013
    ....
  42. Circadian molecular regulation of the xenobiotic response
    Katja A Lamia; Fiscal Year: 2013
    ....
  43. Effects of early-life experience:role of CRH
    Tallie Z Baram; Fiscal Year: 2013
    ..The resulting information would enable us to use the same mechanisms as a basis for therapy in people who have not had the same type of optimal childhood experience. ..
  44. GLUCOCORTICOSTEROID ACTION IN INFLAMMATORY DISEASE
    Robert P Schleimer; Fiscal Year: 2013
    ..Our successful completion of the aims described in this proposal will yield valuable new insight into the mechanisms of glucocorticoid action in human disease. ..
  45. Mechanisms of BDNF and Glucocorticoid Action
    Michael J Garabedian; Fiscal Year: 2013
    ..abstract_text> ..
  46. Stress, Gene-Environment Interaction and Cardiovascular Disease
    Belinda L Needham; Fiscal Year: 2013
    ..This approach is necessary to better understand the importance of stress and to develop preventative interventions. ..
  47. Dysregulated Hypothalamic-pituitary-adrenal Axis During Biliary Hyperplasia
    Sharon Demorrow; Fiscal Year: 2013
    ..acids by bile acid transporters into neurons of particular brain regions and subsequent activation of glucocorticoid receptors, and (3) Reactivation of the HPA axis by central administration of corticotropin releasing hormone ..
  48. Airway Inflammatory Pathways Regulating Glucocorticoid Receptor Phosphorylation
    Omar Tliba; Fiscal Year: 2013
    ..This integrated translational approach is expected to advance our understanding of the cellular and molecular mechanisms that contribute to the development of steroid insensitivity in severe asthmatic patients. ..
  49. Functional analysis of leukemic CREBBP mutations
    Charles G Mullighan; Fiscal Year: 2013
    ..The translational impact of the results will be to enhance the knowledge-driven therapeutic use of glucocorticoids and HDACi to treat leukemia based on tumor cell genotype. ..
  50. Glucocorticoid Receptor Function in Steroid Resistant Childhood Nephrotic Syndrom
    JORGE A INIGUEZ LLUHI; Fiscal Year: 2010
    ..This knowledge would prevent unnecessary exposure to steroids for resistant children and would enable earlier treatment with other classes of drugs. ..
  51. Early Life Stress and Corticosterone Signaling: Relation to Ethanol Drinking
    TRACY RENEE BUTLER; Fiscal Year: 2013
    ....
  52. Co-factors in HIV Mucosal Infection
    Gregory A Viglianti; Fiscal Year: 2012
    ..We will test these drugs for their ability to inhibit HIV-1 transmission using purified cells and a unique laboratory-derived tissue model of the female reproductive tract. ..
  53. Risky Family Environments and Childhood Asthma
    Richard B Slatcher; Fiscal Year: 2013
    ..abstract_text> ..
  54. Quantitative Dissection of Steroid Receptor Function
    David L Bain; Fiscal Year: 2013
    ..Cellular occupancy at the promoter will be determined by chromatin immunoprecipitation (ChIP) assays, and the extent of mRNA production will be determined by quantitative RT-PCR. ..
  55. TPR Proteins in Steroid Receptor Signaling & Physiology
    EDWIN SANCHEZ; Fiscal Year: 2009
    ..A better understanding of differential TPR protein effects on both GR and PR could now form the basis for new therapeutic strategies targeting fertility and other physiologies. ..
  56. Synaptic Changes by Stress in Prefrontal Cortex
    Zhen Yan; Fiscal Year: 2013
    ....
  57. The role of NDRG1 in collecting duct function.
    ANIKO NARAY FEJES TOTH; Fiscal Year: 2010
    ..Furthermore, we are trying to understand the mechanisms by which different steroid hormone receptors exert specific actions on the kidney. ..
  58. Molecular Analysis of Steroid Hormone Receptors with X-ray Crystallography
    Kendall W Nettles; Fiscal Year: 2010
    ..Importantly, this approach will also directly impact the drug discovery process, by rapidly providing structural information that will guide the development of new therapeutics. ..
  59. Anti-inflammatory and Mitotic Properties of Non-hormonal Steroids in Lung Epithel
    ERICA REEVES; Fiscal Year: 2010
    ..The 5 most optimal compounds will be tested in an ex vivo model with the goal of identifying 2-3 lead compounds to take into the mouse model for asthma. ..
  60. Impact of Sudden Parental Death on Children and Families
    David A Brent; Fiscal Year: 2012
    ..However, there have been no long-term, controlled, prospective studies of the effects of parental bereavement on children. ..
  61. Molecular effects of mind-body intervention on GC sensitivity and immune function
    JEFFREY MILUSH; Fiscal Year: 2013
    ..The long-term goal of this application is to develop new assays necessary to study the mechanisms by which stress hormones control immune cell function and how mind-body interventions 'reset'this communication pathway. ..
  62. The Role of HDAC6 and Glucocorticoid Signaling in Resilience to Depression
    Sarah L Teegarden; Fiscal Year: 2011
    ..If our hypothesis that loss of HDAC6 enhances resilience to stress via inhibition of glucocorticoid signaling proves correct, it could open a promising new avenue of therapeutic interventions for these disorders. ..
  63. MOLECULAR BASIS OF HIV LIPODYSTROPHY: ROLE OF VPR
    Ashok Balasubramanyam; Fiscal Year: 2003
    ....
  64. Glucocorticoid mechanisms of neonatal separation effects on adult learning
    Aaron A Wilber; Fiscal Year: 2009
    ..S. citizens are affected by mental disorders every year. Understanding the mental health consequences of intentional (e.g., abuse and neglect) and unintentional (e.g., NICU) perinatal stressors is crucial to preventative treatment. ..
  65. VITAMIN B-6 AND STERIOD HORMONE ACTION
    JOHN CIDLOWSKI; Fiscal Year: 1991
    ..Furthermore, we have presented evidence which demonstrates that glucocorticoid receptors are subject to pyridoxylation in vivo...
  66. GLUCOCORTICOSTEROID ACTION IN INFLAMMATORY DISEASE
    Robert Schleimer; Fiscal Year: 2009
    ..Studies in this grant will test whether these hypotheses are correct and give us valuable new insight into the pathogenesis of chronic rhinosinusitis as well as the mechanism by which steroids improve it. ..
  67. REGULATION OF GLUCOCORTICOID RECEPTOR BY PHOSPHORYLATION
    Michael Garabedian; Fiscal Year: 2002
    ....
  68. GLUCOCORTICOID REGULATION OF GENETIC OBESITY
    David York; Fiscal Year: 1999
    ..A fuller understanding of the factors which cause and maintain obesity will promote new approaches to the treatment and prevention of the obese state and contribute to an improvement in the health of Western populations. ..
  69. Steroid As Cytoprotectants against Oxidative Toxicity
    Qin Chen; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  70. ENDOGENOUS STEROID RECEPTOR STABILIZING FACTOR
    WILLIAM PRATT; Fiscal Year: 2000
    ....
  71. EARLY ABUSE AND CORTICOLIMBIC DEVELOPMENT
    Martin Teicher; Fiscal Year: 1999
    ..Measures of lymphocyte glucocorticoid receptors, and platelet alpha-2 receptors will provide covariate data on alterations in HPA axis and catecholamine ..