estrogen receptor beta

Summary

Summary: One of the ESTROGEN RECEPTORS that has greater affinity for ISOFLAVONES than ESTROGEN RECEPTOR ALPHA does. There is great sequence homology with ER alpha in the DNA-binding domain but not in the ligand binding and hinge domains.

Top Publications

  1. pmc Estrogen receptor beta binds to and regulates three distinct classes of target genes
    Omar I Vivar
    Department of Nutritional Science and Toxicology, University of California, Berkeley, California 94720, USA
    J Biol Chem 285:22059-66. 2010
  2. ncbi Estrogen receptor beta inhibits human breast cancer cell proliferation and tumor formation by causing a G2 cell cycle arrest
    Sreenivasan Paruthiyil
    Department of Obstetrics, University of California, San Francisco, CA 94143 0556, USA
    Cancer Res 64:423-8. 2004
  3. ncbi The different roles of ER subtypes in cancer biology and therapy
    Christoforos Thomas
    Center for Nuclear Receptors and Cell Signalling, Department of Biology and Biochemistry, University of Houston, Houston 77204, Texas, USA
    Nat Rev Cancer 11:597-608. 2011
  4. ncbi Estrogen receptor beta (ERβ) produces autophagy and necroptosis in human seminoma cell line through the binding of the Sp1 on the phosphatase and tensin homolog deleted from chromosome 10 (PTEN) promoter gene
    Carmela Guido
    Department of Pharmaco Biology, Post Graduate School of Clinical Pathology, University of Calabria, Rende, Italy
    Cell Cycle 11:2911-21. 2012
  5. ncbi Novel actions of estrogen receptor-beta on anxiety-related behaviors
    Trent D Lund
    Department of Biomedical Science, Colorado State University, Anatomy W103, 1617 Campus Delivery, Fort Collins, Colorado 80523 1670, USA
    Endocrinology 146:797-807. 2005
  6. ncbi Estrogen receptors and the metabolic network
    Rodrigo P A Barros
    Center for Nuclear Receptors and Cell Signaling, Department of Cell Biology and Biochemistry, University of Houston, Houston, TX 77004, USA
    Cell Metab 14:289-99. 2011
  7. ncbi Effect of single and compound knockouts of estrogen receptors alpha (ERalpha) and beta (ERbeta) on mouse reproductive phenotypes
    S Dupont
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, College de France, BP 163, France
    Development 127:4277-91. 2000
  8. ncbi Pyrazolo[1,5-a]pyrimidines: estrogen receptor ligands possessing estrogen receptor beta antagonist activity
    Dennis R Compton
    Department of Chemistry and Department of Molecular and Integrative Physiology, University of Illinois, 600 South Matthews Avenue, Urbana, Illinois 61801, USA
    J Med Chem 47:5872-93. 2004
  9. ncbi Development of subtype-selective oestrogen receptor-based therapeutics
    Stefan Nilsson
    Karo Bio AB, Novum, SE 141 57 Huddinge, Sweden
    Nat Rev Drug Discov 10:778-92. 2011
  10. pmc Estrogen receptor (ER) beta, a modulator of ERalpha in the uterus
    Z Weihua
    Department of Medical Nutrition, Karolinska Institute, Novum, S 141 86 Huddinge, Sweden
    Proc Natl Acad Sci U S A 97:5936-41. 2000

Research Grants

Detail Information

Publications359 found, 100 shown here

  1. pmc Estrogen receptor beta binds to and regulates three distinct classes of target genes
    Omar I Vivar
    Department of Nutritional Science and Toxicology, University of California, Berkeley, California 94720, USA
    J Biol Chem 285:22059-66. 2010
    b>Estrogen receptor beta (ERbeta) has potent antiproliferative and anti-inflammatory properties, suggesting that ERbeta-selective agonists might be a new class of therapeutic and chemopreventive agents...
  2. ncbi Estrogen receptor beta inhibits human breast cancer cell proliferation and tumor formation by causing a G2 cell cycle arrest
    Sreenivasan Paruthiyil
    Department of Obstetrics, University of California, San Francisco, CA 94143 0556, USA
    Cancer Res 64:423-8. 2004
    ..Natural or synthetic ERbeta-selective estrogens may lack breast cancer promoting properties exhibited by estrogens in hormone replacement regimens and may be useful for chemoprevention of breast cancer...
  3. ncbi The different roles of ER subtypes in cancer biology and therapy
    Christoforos Thomas
    Center for Nuclear Receptors and Cell Signalling, Department of Biology and Biochemistry, University of Houston, Houston 77204, Texas, USA
    Nat Rev Cancer 11:597-608. 2011
    ..The changes in the bioavailability of ERs in tumours, together with their specific biological functions, promote the selective restoration of their activity as one of the major therapeutic approaches for hormone-dependent cancers...
  4. ncbi Estrogen receptor beta (ERβ) produces autophagy and necroptosis in human seminoma cell line through the binding of the Sp1 on the phosphatase and tensin homolog deleted from chromosome 10 (PTEN) promoter gene
    Carmela Guido
    Department of Pharmaco Biology, Post Graduate School of Clinical Pathology, University of Calabria, Rende, Italy
    Cell Cycle 11:2911-21. 2012
    ..These data, supporting estrogen-dependency of human seminoma, propose ERβ ligands for therapeutic use in the treatment of this pathological condition...
  5. ncbi Novel actions of estrogen receptor-beta on anxiety-related behaviors
    Trent D Lund
    Department of Biomedical Science, Colorado State University, Anatomy W103, 1617 Campus Delivery, Fort Collins, Colorado 80523 1670, USA
    Endocrinology 146:797-807. 2005
    ..Tamoxifen blocked the previously identified anxiolytic actions of DPN. Taken together, these findings suggest that the anxiolytic properties of estrogens are ERbeta mediated...
  6. ncbi Estrogen receptors and the metabolic network
    Rodrigo P A Barros
    Center for Nuclear Receptors and Cell Signaling, Department of Cell Biology and Biochemistry, University of Houston, Houston, TX 77004, USA
    Cell Metab 14:289-99. 2011
    ..Imbalance of ERα/ERβ ratio in this "metabolic network" may lead to the metabolic syndrome...
  7. ncbi Effect of single and compound knockouts of estrogen receptors alpha (ERalpha) and beta (ERbeta) on mouse reproductive phenotypes
    S Dupont
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, College de France, BP 163, France
    Development 127:4277-91. 2000
    ..Our results also show that cell proliferation in the prostate and urinary bladder of old ERbetaKO and ERalphabetaKO males is apparently normal...
  8. ncbi Pyrazolo[1,5-a]pyrimidines: estrogen receptor ligands possessing estrogen receptor beta antagonist activity
    Dennis R Compton
    Department of Chemistry and Department of Molecular and Integrative Physiology, University of Illinois, 600 South Matthews Avenue, Urbana, Illinois 61801, USA
    J Med Chem 47:5872-93. 2004
    ....
  9. ncbi Development of subtype-selective oestrogen receptor-based therapeutics
    Stefan Nilsson
    Karo Bio AB, Novum, SE 141 57 Huddinge, Sweden
    Nat Rev Drug Discov 10:778-92. 2011
    ....
  10. pmc Estrogen receptor (ER) beta, a modulator of ERalpha in the uterus
    Z Weihua
    Department of Medical Nutrition, Karolinska Institute, Novum, S 141 86 Huddinge, Sweden
    Proc Natl Acad Sci U S A 97:5936-41. 2000
    ....
  11. pmc Global analysis of estrogen receptor beta binding to breast cancer cell genome reveals an extensive interplay with estrogen receptor alpha for target gene regulation
    Oli M V Grober
    Department of General Pathology, Second University of Naples, vico L, De Crecchio 7, 80138 Napoli, Italy
    BMC Genomics 12:36. 2011
    ..The identification of the genomic targets of ERβ in hormone-responsive BC cells is thus a critical step to elucidate the roles of this receptor in estrogen signaling and tumor cell biology...
  12. pmc Generation and reproductive phenotypes of mice lacking estrogen receptor beta
    J H Krege
    Department of Pathology, University of North Carolina, Chapel Hill, NC 27599 7525, USA
    Proc Natl Acad Sci U S A 95:15677-82. 1998
    ..Here we describe the generation of mice lacking estrogen receptor beta (ERbeta -/-) by insertion of a neomycin resistance gene into exon 3 of the coding gene by using homologous ..
  13. ncbi Structure-function relationship of estrogen receptor alpha and beta: impact on human health
    Paolo Ascenzi
    Department of Biology, University Roma Tre, Viale Guglielmo Marconi 446, I 00146 Roma, Italy
    Mol Aspects Med 27:299-402. 2006
    ....
  14. pmc Estrogen receptor beta inhibits 17beta-estradiol-stimulated proliferation of the breast cancer cell line T47D
    Anders Strom
    Department of Biosciences, Karolinska Institutet, Novum, S 14157 Huddinge, Sweden
    Proc Natl Acad Sci U S A 101:1566-71. 2004
    ..These findings suggest a possible role for ERbeta in breast cancer and imply that ERbeta-specific ligands may reduce proliferation of ER-positive breast cancer cells through actions on the G(1) phase cell-cycle machinery...
  15. ncbi International Union of Pharmacology. LXIV. Estrogen receptors
    Karin Dahlman-Wright
    Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden
    Pharmacol Rev 58:773-81. 2006
  16. ncbi Estrogen receptors: therapies targeted to receptor subtypes
    S Nilsson
    Karo Bio AB, Novum, Huddinge, Sweden
    Clin Pharmacol Ther 89:44-55. 2011
    ..It must be stated, however, that appropriate clinical studies are necessary to validate these compounds as agents for the prevention and treatment of diseases...
  17. pmc Pancreatic insulin content regulation by the estrogen receptor ER alpha
    Paloma Alonso-Magdalena
    Instituto de Bioingenieria, Universidad Miguel Hernandez de Elche, Alicante, Spain
    PLoS ONE 3:e2069. 2008
    ..The up-regulation of pancreatic insulin content by ER alpha activation involves ERK1/2. These data may be important to explain the actions of E2 and environmental estrogens in endocrine pancreatic function and blood glucose homeostasis...
  18. pmc An ADIOL-ERβ-CtBP transrepression pathway negatively regulates microglia-mediated inflammation
    Kaoru Saijo
    Department of Cellular and Molecular Medicine, School of Medicine, University of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92093, USA
    Cell 145:584-95. 2011
    ..These findings provide evidence for an ADIOL/ERβ/CtBP-transrepression pathway that regulates inflammatory responses in microglia and can be targeted by selective ERβ modulators...
  19. pmc ERbeta impedes prostate cancer EMT by destabilizing HIF-1alpha and inhibiting VEGF-mediated snail nuclear localization: implications for Gleason grading
    Paul Mak
    Department of Cancer Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Cancer Cell 17:319-32. 2010
    High Gleason grade prostate carcinomas are aggressive, poorly differentiated tumors that exhibit diminished estrogen receptor beta (ERbeta) expression...
  20. ncbi Nongenotropic, sex-nonspecific signaling through the estrogen or androgen receptors: dissociation from transcriptional activity
    S Kousteni
    Division of Endocrinology and Metabolism, Center for Osteoporosis and Metabolic, Bone Diseases, University of Arkansas for Medical Sciences and, the Central Arkansas Veterans Health Care, System, Little Rock, AR 72205, USA
    Cell 104:719-30. 2001
    ....
  21. pmc A variant of estrogen receptor-{alpha}, hER-{alpha}36: transduction of estrogen- and antiestrogen-dependent membrane-initiated mitogenic signaling
    Zhaoyi Wang
    Cancer Center, Creighton University, 2500 California Plaza, Omaha, NE 68178, USA
    Proc Natl Acad Sci U S A 103:9063-8. 2006
    ....
  22. ncbi Activities of estrogen receptor alpha- and beta-selective ligands at diverse estrogen responsive gene sites mediating transactivation or transrepression
    William R Harrington
    Department of Molecular and Integrative Physiology, University of Illinois, 407 S Goodwin Avenue, 524 Burrill Hall, Urbana, IL 61801 3704, USA
    Mol Cell Endocrinol 206:13-22. 2003
    ....
  23. ncbi Comparative distribution of estrogen receptor-alpha and -beta mRNA in the rat central nervous system
    P J Shughrue
    The Women s Health Research Institute, Wyeth Ayerst Research, Radnor, Pennsylvania 19087, USA
    J Comp Neurol 388:507-25. 1997
    ..In addition, this comparative study provides evidence that the region-specific expression of ER-alpha, ER-beta, or both may be important in determining the physiological responses of neuronal populations to estrogen action...
  24. pmc Estradiol downregulates miR-21 expression and increases miR-21 target gene expression in MCF-7 breast cancer cells
    Nalinie S Wickramasinghe
    Department of Biochemistry and Molecular Biology, Center for Genetics and Molecular Medicine, University of Louisville School of Medicine, Louisville, KY 40292, USA
    Nucleic Acids Res 37:2584-95. 2009
    ..These results are the first to demonstrate that E(2) represses the expression of an oncogenic miRNA, miR-21, by activating estrogen receptor in MCF-7 cells...
  25. ncbi Human estrogen receptor beta-gene structure, chromosomal localization, and expression pattern
    E Enmark
    Center for Biotechnology, Novum, Huddinge, Sweden
    J Clin Endocrinol Metab 82:4258-65. 1997
    ..In addition, we find ER beta in ovarian granulosa cells, indicating that estrogens also participate in the regulation of follicular growth in the human...
  26. ncbi Deletion of estrogen receptors reveals a regulatory role for estrogen receptors-beta in bone remodeling in females but not in males
    N A Sims
    Department of Orthopaedics, Yale University School of Medicine, New Haven, CT 06520 8044, USA
    Bone 30:18-25. 2002
    ..Thus, only ERalpha was shown to regulate bone remodeling in males, whereas in females both receptor subtypes influenced this process and could, at least under basal knockout conditions, compensate for each other...
  27. ncbi Antagonists selective for estrogen receptor alpha
    Jun Sun
    Department of Molecular and Integrative Physiology, University of Illinois and University of Illinois College of Medicine, Urbana, Illinois 61801, USA
    Endocrinology 143:941-7. 2002
    ..These compounds should be useful in studying the biological functions of ER(alpha) and ER(beta) and in selectively blocking responses that are mediated through ER(alpha)...
  28. ncbi Allosteric regulation of estrogen receptor structure, function, and coactivator recruitment by different estrogen response elements
    Julie M Hall
    Receptor Biology Section, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Mol Endocrinol 16:469-86. 2002
    ....
  29. ncbi The pancreatic beta-cell as a target of estrogens and xenoestrogens: Implications for blood glucose homeostasis and diabetes
    Angel Nadal
    Instituto de Bioingeniería and CIBER de Diabetes y Enfermedades Metabólicas Asociadas, Universidad Miguel Hernandez de Elche, Alicante, Spain
    Mol Cell Endocrinol 304:63-8. 2009
    ..This may provoke insulin resistance in the liver and muscle, as well as beta-cell exhaustion and therefore, it may contribute to the development of type II diabetes...
  30. ncbi Loss of estrogen receptor beta expression correlates with shorter overall survival and lack of clinical response to chemotherapy in ovarian cancer patients
    Agnieszka Halon
    Department of Pathomorphology, Wroclaw Medical University, Marcinkowskiego 1, 50 368 Wroclaw, Poland
    Anticancer Res 31:711-8. 2011
    b>Estrogen receptor beta (ERβ) belongs to a large family of nuclear receptors. Recent studies have suggested that ERβ in contrast to ERα might act as a tumour suppressor in ovarian cancer (OVCA).
  31. pmc Estrogen receptor-beta sensitizes breast cancer cells to the anti-estrogenic actions of endoxifen
    Xianglin Wu
    Department of Biochemistry and Molecular Biology, Mayo Clinic, 200 1stStreet SW, Rochester, MN 55905, USA
    Breast Cancer Res 13:R27. 2011
    ..Here, we characterize the molecular actions of endoxifen in breast cancer cells expressing ERβ and examine its effectiveness as an anti-estrogenic agent in these cell lines...
  32. pmc Estrogen receptor β represses Akt signaling in breast cancer cells via downregulation of HER2/HER3 and upregulation of PTEN: implications for tamoxifen sensitivity
    Karolina Lindberg
    Department of Biosciences and Nutrition, Novum, Karolinska Institutet, Blickagången 6, S 141 83 Huddinge, Sweden
    Breast Cancer Res 13:R43. 2011
    ..The mechanisms behind this observation remain largely uncharacterized. In the present study, we investigated whether ERβ can modulate pathways implicated in endocrine resistance development...
  33. pmc The basic helix-loop-helix-PAS protein ARNT functions as a potent coactivator of estrogen receptor-dependent transcription
    Sara Brunnberg
    Department of Cell and Molecular Biology, Karolinska Institutet, S 171 77 Stockholm, Sweden
    Proc Natl Acad Sci U S A 100:6517-22. 2003
    ..ARNT was furthermore recruited to a natural ER target gene promoter in a estrogen-dependent manner, supporting a physiological role for ARNT as an ER coactivator...
  34. ncbi Estrogen receptors alfa (ERalpha) and beta (ERbeta) differentially regulate proliferation and apoptosis of the normal murine mammary epithelial cell line HC11
    Luisa A Helguero
    Department of Medical Nutrition, Karolinska Institutet, Novum, Huddinge, Sweden
    Oncogene 24:6605-16. 2005
    ..The possible use of estrogen receptor beta (ERbeta) as a target in treatment of breast cancer is under investigation...
  35. ncbi Estrogen receptor beta exerts growth-inhibitory effects on human mammary epithelial cells
    Oliver Treeck
    Department of Obstetrics and Gynecology, University of Regensburg, 93053, Regensburg, Germany
    Breast Cancer Res Treat 120:557-65. 2010
    b>Estrogen receptor beta (ERbeta) is widely expressed in mammary epithelium. ERbeta expression is reported to decline during carcinogenesis of the breast and other tissues...
  36. pmc Influence of cellular ERalpha/ERbeta ratio on the ERalpha-agonist induced proliferation of human T47D breast cancer cells
    Ana M Covaleda Sotoca
    Toxicology Section, Wageningen University, Tuinlaan 5, 6703 HE, Wageningen, The Netherlands
    Toxicol Sci 105:303-11. 2008
    ....
  37. ncbi Loss of estrogen receptor beta isoform expression and its correlation with aberrant DNA methylation of the 5'-untranslated region in human epithelial ovarian carcinoma
    Fumihiko Suzuki
    Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai 980 8574, Japan
    Cancer Sci 99:2365-72. 2008
    ..The results of our present study suggest that ERbeta is inactivated mainly through aberrant DNA methylation. This process may play an important role in the pathogenesis of epithelial ovarian cancer...
  38. ncbi The skeletal responsiveness to mechanical loading is enhanced in mice with a null mutation in estrogen receptor-beta
    L K Saxon
    Department of Orthopaedic Surgery, Indiana University Purdue University, Indianapolis, USA
    Am J Physiol Endocrinol Metab 293:E484-91. 2007
    ..001). We conclude that estrogen signaling through ER-beta suppresses the mechanical loading response on the periosteal surface of long bones...
  39. ncbi Activation of estrogen receptor-beta regulates hippocampal synaptic plasticity and improves memory
    Feng Liu
    Wyeth Research, Discovery Neuroscience, 865 Ridge Road, Monmouth Junction, New Jersey 08852, USA
    Nat Neurosci 11:334-43. 2008
    ..Our data suggest that activation of ERbeta can regulate hippocampal synaptic plasticity and improve hippocampus-dependent cognition...
  40. ncbi Tumor repressive functions of estrogen receptor beta in SW480 colon cancer cells
    Johan Hartman
    Department of Biosciences and Nutrition, Karolinska Institutet, Novum, Huddinge, Sweden
    Cancer Res 69:6100-6. 2009
    b>Estrogen receptor beta (ERbeta) is the predominant ER in the colorectal epithelium. Compared with normal colon tissue, ERbeta expression is reduced in colorectal cancer...
  41. ncbi New roles for estrogen receptor beta in behavior and neuroendocrinology
    Cristian Bodo
    Graduate Program in Neuroscience, Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, 22908, USA
    Front Neuroendocrinol 27:217-32. 2006
    In this review we critically examine the data on functions of the estrogen receptor beta (ERbeta) in both behavior and neuroendocrinology...
  42. ncbi Clinical significance of estrogen receptor beta in breast cancer
    Shigehira Saji
    Department of Surgery and Breast Oncology, Tokyo Metropolitan Komagome Hospital, 3 18 22 Honkomagome, Bunkyo ku, 113 8677, Tokyo, Japan
    Cancer Chemother Pharmacol 56:21-6. 2005
    ..A selective estrogen receptor modulator, which works as an antagonist of ERalpha and an agonist of ERbeta, may be a promising chemo-preventive treatment...
  43. ncbi Impact of estrogen receptor beta on gene networks regulated by estrogen receptor alpha in breast cancer cells
    Edmund C Chang
    Department of Molecular and Integrative Physiology, University of Illinois, 524 Burrill Hall, 407 South Goodwin Avenue, Urbana, 61801 3704, USA
    Endocrinology 147:4831-42. 2006
    ..Our observations suggest that the relative levels of ERbeta and ERalpha in breast cancers are likely to impact cell proliferation and the activities of diverse signaling pathways and their response to ER ligands and endocrine therapies...
  44. pmc Estrogen receptor beta: an overview and update
    Chunyan Zhao
    Department of Biosciences and Nutrition, Novum, Karolinska Institutet, Huddinge, Sweden
    Nucl Recept Signal 6:e003. 2008
    ..ERbeta agonists are being explored and validated as drugs for a growing number of indications. Hopefully, some ERbeta targeted drugs will prove to be efficient in enhancing human health...
  45. ncbi Correlated downregulation of estrogen receptor beta and the circadian clock gene Per1 in human colorectal cancer
    Nazanin Mostafaie
    Department of Clinical Chemistry, Donauspital, Vienna, Austria
    Mol Carcinog 48:642-7. 2009
    ..The observed gender differences in the expression of CLOCK and Per1 in G(2) tumors might suggest a gender-specific, distinctive role of the cellular clock in colorectal tumorigenesis...
  46. ncbi Estrogen receptor beta expression is associated with tamoxifen response in ERalpha-negative breast carcinoma
    Sofia K Gruvberger-Saal
    Department of Oncology and Theoretical Physics, Lund University, Lund, Sweden
    Clin Cancer Res 13:1987-94. 2007
    ..The aim of the present study was to elucidate the biology and prognostic role of the second ER, ERbeta, in patients treated with adjuvant tamoxifen...
  47. pmc Comparative studies of the estrogen receptors beta and alpha and the androgen receptor in normal human prostate glands, dysplasia, and in primary and metastatic carcinoma
    I Leav
    Department of Pathology, Schools of Medicine and Veterinary Medicine, Tufts University, Boston, Massachusetts, USA
    Am J Pathol 159:79-92. 2001
    ..Based on our recent finding of anti-estrogen/ER-beta-mediated growth inhibition of prostate cancer cells in vitro, the presence of ER-beta in metastatic cells may have important implications for the treatment of late-stage disease...
  48. pmc Loss of ERbeta expression as a common step in estrogen-dependent tumor progression
    A Bardin
    Unité INSERM 540, 60 rue de Navacelles, 34090 Montpellier, France
    Endocr Relat Cancer 11:537-51. 2004
    The characterization of estrogen receptor beta (ERbeta) brought new insight into the mechanisms underlying estrogen signaling...
  49. ncbi The biological role of estrogen receptors alpha and beta in cancer
    Sandra Timm Pearce
    Robert H Lurie Comprehensive Cancer Center, The Feinberg School of Medicine, Olson Pavilion, Room 8258, Northwestern University, 303 E Chicago Avenue, Chicago, IL 60611, USA
    Crit Rev Oncol Hematol 50:3-22. 2004
    ..An ultimate goal of current research is to enhance the value of the separate estrogen receptors as targets for therapeutic intervention...
  50. ncbi Estrogen receptor alpha in human breast cancer: occurrence and significance
    S Ali
    CRC Laboratories, Department of Cancer Medicine, Imperial College School of Medicine, Hammersmith Hospital, London
    J Mammary Gland Biol Neoplasia 5:271-81. 2000
    ....
  51. pmc Proestrous compared to diestrous wildtype, but not estrogen receptor beta knockout, mice have better performance in the spontaneous alternation and object recognition tasks and reduced anxiety-like behavior in the elevated plus and mirror maze
    Alicia A Walf
    Dept of Psychology, The University at Albany State University of New York, Albany, NY 12222, USA
    Behav Brain Res 196:254-60. 2009
    ..Thus, enhanced performance in cognitive tasks and anti-anxiety-like behavior of proestrous mice may require actions of ERbeta in the hippocampus and/or cortex...
  52. pmc Muscle GLUT4 regulation by estrogen receptors ERbeta and ERalpha
    Rodrigo P A Barros
    Department of Biosciences and Nutrition, Karolinska Institute, S 141 86 Novum, Sweden
    Proc Natl Acad Sci U S A 103:1605-8. 2006
    ....
  53. pmc Expression of oestrogen receptor-beta in oestrogen receptor-alpha negative human breast tumours
    G P Skliris
    Department of Biochemistry and Medical Genetics, Manitoba Institute of Cell Biology, University of Manitoba, Winnipeg, Manitoba, Canada R3E OV9
    Br J Cancer 95:616-26. 2006
    ..Based on our in vivo observations, ERbeta may have the potential to become a therapeutic target in the specific subcohort of ERalpha-negative breast cancers...
  54. pmc Liquiritigenin is a plant-derived highly selective estrogen receptor beta agonist
    Jennifer E Mersereau
    Department of Obstetrics, Gynecology and Reproductive Sciences and Center for Reproductive Sciences, Cellular and Molecular Pharmacology, University of California, San Francisco, CA, United States
    Mol Cell Endocrinol 283:49-57. 2008
    ..In a mouse xenograph model, liquiritigenin did not stimulate uterine size or tumorigenesis of MCF-7 breast cancer cells. Our results demonstrate that some plants contain highly selective estrogens for ERbeta...
  55. pmc Estrogen signaling via estrogen receptor {beta}
    Chunyan Zhao
    Department of Biosciences and Nutrition, Novum, Karolinska Institutet, S 141 57 Huddinge, Sweden
    J Biol Chem 285:39575-9. 2010
    ..We also highlight the recent work establishing new roles of ERβ signaling, including protective functions in the epithelial-mesenchymal transition and in atherosclerosis, as well as regulation of cell proliferation in the colon...
  56. ncbi Characterization of the hypothalamic-pituitary-gonadal axis in estrogen receptor (ER) Null mice reveals hypergonadism and endocrine sex reversal in females lacking ERalpha but not ERbeta
    John F Couse
    Receptor Biology Section, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, MD B3 02, P O Box 12233, Research Triangle Park, North Carolina 27709, USA
    Mol Endocrinol 17:1039-53. 2003
    ..The subsequent hypergonadism is illustrated as increased Cyp17, Cyp19, Hsd17b1, and ectopic Hsd17b3 expression in the ovary...
  57. ncbi Mouse estrogen receptor beta forms estrogen response element-binding heterodimers with estrogen receptor alpha
    K Pettersson
    Department of Medical Nutrition and Center for Biotechnology, Karolinska Institute, Huddinge, Sweden
    Mol Endocrinol 11:1486-96. 1997
    ....
  58. ncbi Immunolocalization of estrogen receptor beta in the mouse brain: comparison with estrogen receptor alpha
    Sudha Warrier Mitra
    Department of Atherosclerosis and Endocrinology, Merck Research Laboratories, Rahway, New Jersey 07065, USA
    Endocrinology 144:2055-67. 2003
    ..These data provide an anatomical framework for understanding the mechanisms by which estrogen regulates specific neural systems in the mouse...
  59. ncbi Estrogen receptor alpha and beta are prognostic factors in non-small cell lung cancer
    Hideki Kawai
    Division of Thoracic Surgery, Department of Surgery, Akita University School of Medicine, Akita, Japan
    Clin Cancer Res 11:5084-9. 2005
    ..Our goal was to investigate ER expression in non-small cell lung cancer (NSCLC) and to assess whether their expression correlates with prognosis...
  60. ncbi Diarylheptanoids, new phytoestrogens from the rhizomes of Curcuma comosa: Isolation, chemical modification and estrogenic activity evaluation
    Apichart Suksamrarn
    Department of Chemistry, Faculty of Science, Ramkhamhaeng University, Bangkok 10240, Thailand
    Bioorg Med Chem 16:6891-902. 2008
    ....
  61. ncbi Expression of ER-alpha and ER-beta in the hamster ovary: differential regulation by gonadotropins and ovarian steroid hormones
    Peixin Yang
    Department of Obstetrics and Gynecology, University of Nebraska Medical Center, Omaha, Nebraska 68198 4515, USA
    Endocrinology 143:2385-98. 2002
    ..ER expression was stimulated by estrogen, but progesterone strongly inhibited estrogen action. These results indicate that ER expression is cell type specific to the larger extent and is critically regulated by reproductive hormones...
  62. pmc Estrogen receptor-beta prevents cardiac fibrosis
    Ali Pedram
    Medical Service 111 I, Department of Veterans Affairs Medical Center, 5901 East 7th Street, Long Beach, California 90822, USA
    Mol Endocrinol 24:2152-65. 2010
    ..Our results establish the cardiac fibroblast as an important target for hypertrophic/fibrosis-inducing peptides the actions of which were mitigated by E2/ERβ acting in these stromal cells...
  63. ncbi Estrogen receptor beta increases the efficacy of antiestrogens by effects on apoptosis and cell cycling in breast cancer cells
    Leslie Hodges-Gallagher
    Department of Medicine, University of California, San Francisco, CA 94143, USA
    Breast Cancer Res Treat 109:241-50. 2008
    Clinical evidence indicates that higher levels of estrogen receptor beta (ERbeta) predicts improved disease-free and overall survival in patients treated with adjuvant tamoxifen therapy...
  64. ncbi Human umbilical vascular endothelial cells express estrogen receptor beta (ERbeta) and progesterone receptor A (PR-A), but not ERalpha and PR-B
    Bettina Toth
    Department of Obstetrics and Gynecology, Grosshadern, Ludwig Maximilians University, 81377, Munich, Germany
    Histochem Cell Biol 130:399-405. 2008
    ..PR-A expression could be significantly upregulated with progesterone, again on mRNA and protein level. We conclude that estrogenic effects on HUVEC are mediated via the ERbeta and gestagens act via the PR-A pathway...
  65. ncbi Changes in oestrogen receptor-alpha and -beta during progression to acquired resistance to tamoxifen and fulvestrant (Faslodex, ICI 182,780) in MCF7 human breast cancer cells
    L E Shaw
    School of Biological Sciences, The University of Reading, Reading, RG6 6AJ, UK
    J Steroid Biochem Mol Biol 99:19-32. 2006
    ....
  66. ncbi p300 mediates functional synergism between AF-1 and AF-2 of estrogen receptor alpha and beta by interacting directly with the N-terminal A/B domains
    Y Kobayashi
    Institute of Molecular and Cellular Biosciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-0032, Japan
    J Biol Chem 275:15645-51. 2000
    ..Thus, these findings indicate that ligand-induced functional synergism between AF-1 and AF-2 is mediated through p300 by its direct binding to the A/B regions of ERalpha and ERbeta...
  67. ncbi Estrogenic potency of food-packaging-associated plasticizers and antioxidants as detected in ERalpha and ERbeta reporter gene cell lines
    Marcel G R Ter Veld
    Toxicology Section, Wageningen University, Tuinlaan 5, 6703 HE Wageningen, The Netherlands
    J Agric Food Chem 54:4407-16. 2006
    ....
  68. pmc Combined analysis of estrogen receptor beta-1 and progesterone receptor expression identifies lung cancer patients with poor outcome
    Laura P Stabile
    Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Clin Cancer Res 17:154-64. 2011
    ..Steroid hormones and growth factors affect lung cancer, and it is possible they act in concert to influence patient outcome...
  69. pmc Tamoxifen increases nuclear respiratory factor 1 transcription by activating estrogen receptor beta and AP-1 recruitment to adjacent promoter binding sites
    Margarita M Ivanova
    Department of Biochemistry and Molecular Biology, Center for Genetics and Molecular Medicine, University of Louisville School of Medicine, Louisville, KY 40292, USA
    FASEB J 25:1402-16. 2011
    ..Overall, NRF-1 expression and activity is regulated by 4-OHT via endogenous ERβ in MCF-7 cells...
  70. pmc An alternate pathway for androgen regulation of brain function: activation of estrogen receptor beta by the metabolite of dihydrotestosterone, 5alpha-androstane-3beta,17beta-diol
    Robert J Handa
    Department of Biomedical Sciences Neurosciences Division, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA
    Horm Behav 53:741-52. 2008
    ..These novel findings compel us to re-evaluate the interpretation of past studies and the design of future experiments aimed at elucidating the specific effects of androgen receptor signaling pathways...
  71. ncbi Expression of estrogen receptor (ER) subtypes and ERbeta isoforms in colon cancer
    M Campbell-Thompson
    Department of Medicine, College of Medicine, University of Florida, Gainesville 32610, USA
    Cancer Res 61:632-40. 2001
    ..This information suggests that activation of ERbeta-mediated processes in the superficial colonic epithelium may have a role in the preventive effects observed for female gender and ERT usage...
  72. pmc In vitro and in vivo molecular imaging of estrogen receptor α and β homo- and heterodimerization: exploration of new modes of receptor regulation
    Ramasamy Paulmurugan
    Departments of Radiology and Bioengineering, Stanford University School of Medicine, Stanford, California 94305 5427, USA
    Mol Endocrinol 25:2029-40. 2011
    ..They also probe what combinations of ERα and ERβ dimers might be the mediators of the effects of different types of ER ligands given at different doses...
  73. ncbi Therapeutic targeting in the estrogen receptor hormonal pathway
    Benita S Katzenellenbogen
    Department of Molecular and Integrative Physiology, University of Illinois and College of Medicine, Urbana, IL, USA
    Semin Oncol 31:28-38. 2004
    ....
  74. ncbi Direct regulation of microRNA biogenesis and expression by estrogen receptor beta in hormone-responsive breast cancer
    O Paris
    Department of General Pathology, Second University of Naples, Napoli, Italy
    Oncogene 31:4196-206. 2012
    ....
  75. pmc Tamoxifen regulates cell fate through mitochondrial estrogen receptor beta in breast cancer
    M Razandi
    Division of Endocrinology, Medical Service 111 I, Veterans Affairs Medical Center, Long Beach, CA, USA
    Oncogene 32:3274-85. 2013
    Tamoxifen (TAM) has both cytostatic and cytotoxic properties for breast cancer. TAM engaged mitochondrial estrogen receptor beta (ERβ) as an antagonist in MCF7-BK cells, increasing reactive oxygen species (ROS) concentrations from the ..
  76. ncbi Estrogen receptor beta stimulates Egr-1 transcription via MEK1/Erk/Elk-1 cascade in C6 glioma cells
    Ji Ha Kim
    Division of Molecular and Life Sciences, College of Science and Technology, Hanyang University, Ansan, Korea
    BMB Rep 44:452-7. 2011
    ..Our results show that ERβ promoted up-regulation of Egr-1 expression via a non-genomic mechanism involving the Raf/MEK1/Erk/Elk-1 signaling cascade...
  77. ncbi Participation of ERalpha and ERbeta in glucose homeostasis in skeletal muscle and white adipose tissue
    Rodrigo P A Barros
    Department of Biosciences and Nutrition, Karolinska Institutet, Novum, Sweden
    Am J Physiol Endocrinol Metab 297:E124-33. 2009
    ..This tissue-specific difference in dominance of one ER over the other is reflected in the ratio of the expression of the two receptors. ERalpha predominates in WAT and ERbeta in SM...
  78. ncbi Estrogen receptors α and β have different gender-dependent effects on the adaptive responses to load bearing in cancellous and cortical bone
    L K Saxon
    The Royal Veterinary College, Royal College Street London, London NW1 OTU, United Kingdom
    Endocrinology 153:2254-66. 2012
    ..Bone loss due to disuse in cortical bone is unaffected by ER status, but in cancellous bone, functional ERα contributes to greater disuse-related bone loss...
  79. ncbi Plasma folate concentrations are positively associated with risk of estrogen receptor beta negative breast cancer in a Swedish nested case control study
    Ulrika Ericson
    Department of Clinical Sciences, Nutrition Epidemiology, Lund University, Malmo, Sweden
    J Nutr 140:1661-8. 2010
    ..The study contributes knowledge concerning folate's multifaceted role in cancer development. If replicated in other populations, the observations may have implications for public health, particularly regarding folic acid fortification...
  80. ncbi Estrogen regulates tumor growth through a nonclassical pathway that includes the transcription factors ERβ and KLF5
    Yuka Nakajima
    Graduate School of Life and Environmental Sciences, University of Tsukuba, Tsukuba, Ibaraki 305 8577, Japan
    Sci Signal 4:ra22. 2011
    ..Our results demonstrate that estrogens and antiestrogens affect prostate tumor growth through ERβ-mediated regulation of KLF5...
  81. pmc Bisphenol AF is a full agonist for the estrogen receptor ERalpha but a highly specific antagonist for ERbeta
    Ayami Matsushima
    Laboratory of Structure Function Biochemistry, Department of Chemistry, Research Education Centre of Risk Science, Faculty and Graduate School of Sciences, Kyushu University, Fukuoka, Japan
    Environ Health Perspect 118:1267-72. 2010
    ..Because of the lack of adequate toxicity data, bisphenol AF has been nominated for comprehensive toxicological characterization...
  82. pmc Estrogen receptor-beta, estrogen receptor-alpha, and progesterone resistance in endometriosis
    Serdar E Bulun
    Division of Reproductive Biology Research, Department Obstetrics and Gynecology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Semin Reprod Med 28:36-43. 2010
    ..In this review, we propose a molecular model that may be responsible for changes in ERbeta and ERalpha leading to PR loss and progesterone resistance in endometriosis...
  83. ncbi Tissue distribution and quantitative analysis of estrogen receptor-alpha (ERalpha) and estrogen receptor-beta (ERbeta) messenger ribonucleic acid in the wild-type and ERalpha-knockout mouse
    J F Couse
    Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Endocrinology 138:4613-21. 1997
    ..Further characterization of the physiological phenotypes in the ERKO mice may elucidate possible ERbeta specific actions...
  84. pmc Estrogen promotes cutaneous wound healing via estrogen receptor beta independent of its antiinflammatory activities
    Laura Campbell
    Faculty of Life Sciences, University of Manchester, Manchester, England, UK
    J Exp Med 207:1825-33. 2010
    ..Thus, estrogen-mediated antiinflammatory activity is not the principal factor in accelerated wound healing...
  85. pmc Estrogen receptor-beta activated apoptosis in benign hyperplasia and cancer of the prostate is androgen independent and TNFalpha mediated
    Stephen J McPherson
    Prostate and Breast Cancer Research Group, Department of Anatomy and Developmental Biology, Monash University, Clayton, Victoria 3800, Australia
    Proc Natl Acad Sci U S A 107:3123-8. 2010
    ..Our data are indicative of the therapeutic potential of ERbeta agonist for treatment of PCa and/or BPH with or without androgen withdrawal...
  86. ncbi What pharmacologists can learn from recent advances in estrogen signalling
    Jan Ake Gustafsson
    Department of Medical Nutrition, Karolinska Institute, Huddinge University Hospital, S 141 86 Huddinge, Sweden
    Trends Pharmacol Sci 24:479-85. 2003
    ....
  87. pmc Estrogen receptor beta expression in prostate adenocarcinoma
    Mojgan Asgari
    Oncopathology Research Center, Tehran University of Medical Sciences, Tehran 141555983, Iran
    Diagn Pathol 6:61. 2011
    ..The characterization of estrogen receptor beta (ER-b) brought new insight into the mechanisms underlying estrogen signalling...
  88. pmc Estrogen receptor beta rs1271572 polymorphism and invasive ovarian carcinoma risk: pooled analysis within the Ovarian Cancer Association Consortium
    Galina Lurie
    Cancer Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii, United States of America
    PLoS ONE 6:e20703. 2011
    The association of ovarian carcinoma risk with the polymorphism rs1271572 in the estrogen receptor beta (ESR2) gene was examined in 4946 women with primary invasive ovarian carcinoma and 6582 controls in a pooled analysis of ten case-..
  89. ncbi Expression of estrogen receptor beta and phosphorylation of estrogen receptor alpha serine 167 correlate with progression-free survival in patients with metastatic breast cancer treated with aromatase inhibitors
    Kazuyoshi Motomura
    Department of Breast and Endocrine Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka University Graduate School of Medicine, Osaka, Japan
    Oncology 79:55-61. 2010
    ..0107). These data suggest that the expression of ERβ and phosphorylation of ERα Ser167 may be useful prognostic factors in patients with metastatic breast cancer who received first-line AI therapy...
  90. ncbi Human cultured skin fibroblasts express estrogen receptor alpha and beta
    Jozef Haczynski
    Eli Lilly, Medical Department Poland, 01 698 Warszawa, Poland
    Int J Mol Med 10:149-53. 2002
    ..The dominant expression of ER-beta in cultured female skin fibroblasts suggests that ER-beta may play a dominant role in collaboration with ER-alpha in the regulation of estrogen action in skin...
  91. ncbi Localization of androgen and estrogen receptors in adult male mouse reproductive tract
    Qing Zhou
    Department of Veterinary Biosciences, University of Illinois, Urbana 61802, USA
    J Androl 23:870-81. 2002
    ..This study demonstrates that the reproductive tracts of male mice differ considerably from those of rats in expression of ARs and ERs and that caution is needed when extrapolating nuclear steroid receptor data across mammalian species...
  92. pmc Diarylheptanoid phytoestrogens isolated from the medicinal plant Curcuma comosa: biologic actions in vitro and in vivo indicate estrogen receptor-dependent mechanisms
    Wipawee Winuthayanon
    Department of Physiology, Faculty of Science, Mahidol University, Bangkok, Thailand
    Environ Health Perspect 117:1155-61. 2009
    ..Diarylheptanoids isolated from Curcuma comosa Roxb. have been recently identified as phyto estrogens. However, the mechanism underlying their actions has not yet been identified...
  93. pmc Estradiol-17beta-induced human neural progenitor cell proliferation is mediated by an estrogen receptor beta-phosphorylated extracellularly regulated kinase pathway
    Jun Ming Wang
    Department of Pharmacology and Pharmacological Science, University of Southern California, 1985 Zonal Avenue, Los Angeles, California 90089 9121, USA
    Endocrinology 149:208-18. 2008
    ..Therapeutic implications of these findings relevant to hormone therapy and prevention of neurodegenerative disease are discussed...
  94. ncbi Neonatal exposure to endocrine active compounds or an ERbeta agonist increases adult anxiety and aggression in gonadally intact male rats
    Heather B Patisaul
    Department of Zoology, North Carolina State University, 127 David Clark Labs, Raleigh, NC 27695, USA
    Horm Behav 53:580-8. 2008
    ..These findings suggest that neonatal exposure to EACs with agonistic activity on ERbeta may influence affective behavior in adulthood, including anxiety and aggression...
  95. ncbi Androgen receptor or estrogen receptor-beta blockade alters DHEA-, DHT-, and E(2)-induced proliferation and PSA production in human prostate cancer cells
    Julia T Arnold
    Endocrine Section, Laboratory of Clinical Investigation, Division of Intramural Research, National Center for Complementary and Alternative Medicine, National Institutes of Health, Bethesda, Maryland 20892 0933, USA
    Prostate 67:1152-62. 2007
    ..LNCaP and LAPC-4 prostate cancer cells were used to determine whether DHEA-modulated proliferation and prostate specific antigen (PSA) production were mediated via the androgen receptor (AR) and/or ERbeta...
  96. pmc Estrogen receptor alpha, not beta, is a critical link in estradiol-mediated protection against brain injury
    D B Dubal
    Department of Physiology, University of Kentucky College of Medicine, Lexington, KY 40536, USA
    Proc Natl Acad Sci U S A 98:1952-7. 2001
    ..Our discovery that ER alpha mediates protection of the brain carries far-reaching implications for the selective targeting of ERs in the treatment and prevention of neural dysfunction associated with normal aging or brain injury...
  97. ncbi Prenatal LHRH neurons in nasal explant cultures express estrogen receptor beta transcript
    Neda Sharifi
    Cellular and Developmental Neurobiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    Endocrinology 143:2503-7. 2002
    ..Recent evidence indicates that LHRH neurons possess the estrogen receptor beta (ERbeta) subtype postnatally, suggesting that estrogen may act, in part, directly on LHRH neurons...
  98. ncbi Nuclear estrogen receptor beta in lung cancer: expression and survival differences by sex
    Ann G Schwartz
    Population Studies and Prevention Program, and Breast Cancer Program, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Clin Cancer Res 11:7280-7. 2005
    ..Archival lung tissue was evaluated for the presence of nuclear estrogen receptor (ER)-alpha and ER-beta and the relationship between ER status, subject characteristics, and survival...
  99. pmc Estrogen receptor beta as a mitochondrial vulnerability factor
    Shao Hua Yang
    Department of Pharmacology and Neuroscience, Institute for Aging and Alzheimer s Disease Research, University of North Texas Health Science Center, Fort Worth, Texas 76107, USA
    J Biol Chem 284:9540-8. 2009
    We recently demonstrated mitochondrial localization of estrogen receptor beta (ERbeta). We herein confirm the mitochondrial localization of ERbeta by the loss of mitochondrial ERbeta immunoreactivity in ERbeta knockdown cells...
  100. ncbi Age differentially influences estrogen receptor-alpha (ERalpha) and estrogen receptor-beta (ERbeta) gene expression in specific regions of the rat brain
    Melinda E Wilson
    Department of Physiology, College of Medicine, University of Kentucky, 800 Rose Street, Lexington, KY 40536, USA
    Mech Ageing Dev 123:593-601. 2002
    ..In summary, the expression of ERalpha and ERbeta mRNAs is differentially modulated in the aging brain and changes are region specific...
  101. pmc Estradiol inhibits ongoing autoimmune neuroinflammation and NFkappaB-dependent CCL2 expression in reactive astrocytes
    Sébastien N Giraud
    Institut National de la Sante et de la Recherche Medicale, Unité Mixte de Recherche en Santé 546, Hopital Pitie Salpetriere, Paris F 75013, France
    Proc Natl Acad Sci U S A 107:8416-21. 2010
    ....

Research Grants62

  1. Gonadal Steroid Receptors and the Hypothalamo-Pituitary-Adrenal Axis
    Robert J Handa; Fiscal Year: 2013
    ..show that androgens can act directly on PVN neurons in the male rat through a novel pathway that involves estrogen receptor beta (ERbeta), whereas E acts predominantly through ERalpha...
  2. Mechanism of Age-Related Change in Estrogen Receptor Beta Expression in Rat Brain
    JENNE MITCHELL WESTBERRY; Fiscal Year: 2012
    ..Furthermore, we will develop a new methodology that will be critical for examining epigenetic changes in gene expression in a temporal and spatial manner in neural tissue with heterogeneous cell populations. ..
  3. Steroid Regulation of Serotonin in Males
    CYNTHIA LOUISE BETHEA; Fiscal Year: 2013
    ..We hypothesize that serotonin neurons in male primates express estrogen receptor beta (ER[unreadable]) and androgen receptors (AR) and that the balance of activity at these receptors governs ..
  4. Gender Selectivity to Colon Cancer Chemoprevention by NSAIDS
    RAMESH K contact WALI; Fiscal Year: 2010
    ..These findings will have an important bearing on the healthcare recommendations for colon cancer chemoprevention which have to be cognizant of this gender selective efficacy for maximum cost-benefit potential of NSAIDS. ..
  5. Nuclear IRS-1-DNA repair and mutagenesis in medulloblastoma
    Krzysztof Reiss; Fiscal Year: 2012
    ..In this respect, estrogen receptor beta (ER[unreadable]), which is highly expressed in medulloblastomas, can translocate IRS-1 to the nucleus in ..
  6. Equol and Regulation of Prostate Growth
    Robert J Handa; Fiscal Year: 2011
    ..It circulates at high levels, and is concentrated in the prostate. Moreover, equol can selectively bind estrogen receptor beta to activate an anti-proliferative cascade in prostate...
  7. Rat Models for Sex Steroid Action
    Michael J Soares; Fiscal Year: 2013
    ..Estradiol binds and signals through estrogen receptor alpha (ESR1) and estrogen receptor beta (ESR2), while progesterone signals through the progesterone receptor (PGR)...
  8. Acute Estradiol Regulation of Excitatory Synapses in the Hippocampus
    Catherine S Woolley; Fiscal Year: 2013
    ..We will approach this goal by defining cellular mechanisms of acute, estrogen receptor beta (ERbeta)-dependent regulation of synapses in the hippocampus of adult male and female rats...
  9. Development of Estrogen Receptor B Selective Receptor Agonists to Treat Neuropath
    ETHAN SAMUEL BURSTEIN; Fiscal Year: 2012
    ..Acadia Pharmaceuticals has discovered highly selective estrogen receptor beta (ER[unreadable])-agonists that are highly efficacious in animal models of neuropathic pain...
  10. ESTROGEN AND COGNITION OVER THE LIFESPAN
    Thomas C Foster; Fiscal Year: 2010
    ..The results of our experiments may provide the groundwork for future development of ER gene therapies to slow or prevent cognitive decline associated with aging and age- related diseases. ..
  11. Estrogen and Memory: Genetic Variation and Neuroimaging
    Susan K Conroy; Fiscal Year: 2013
    ..We will also investigate how changes in estrogen as a result of breast cancer treatment alter brain function, and relate these changes to memory function. ..
  12. Ligand-independent signaling of estrogen receptor beta and the aging brain
    Toni R Pak; Fiscal Year: 2013
    ..The expected results will further our understanding of ER2 signaling in the post-menopausal brain by elucidating the precise molecular mechanisms that drive estrogen-independent regulation of ER2 target genes. ..
  13. Generation of a Complement C3 Conditional Knockout Mouse
    Cynthia A Lemere; Fiscal Year: 2013
    ..This study will provide important data determining the role of C3 on brain wiring, which will lead ultimately to future studies in models of neurodegenerative diseases. ..
  14. Novel estrogen receptor ligands from plant genomics
    John M Littleton; Fiscal Year: 2012
    ..This technology promises to change this by applying genomics approaches to plant drug discovery in this area. ..
  15. Regulation of the Tryptophan Hydroxylase-2 Promoter by Estrogen
    Ryoko Hiroi; Fiscal Year: 2013
    ..E2- induced increases of TpH2 mRNA are mediated via estrogen receptor beta (ER2), and activation of local ER2 in the DRN is sufficient for this increase in TpH2 mRNA and for ..
  16. Estrogen-ERbeta Axis In Disparity of Prostate Cancer
    Asim B Abdel-Mageed; Fiscal Year: 2013
    ..abstract_text> ..
  17. DNA methylation in aging, race and prostate cancer
    Rajvir Dahiya; Fiscal Year: 2006
    ..This information can be used for better management of prostate cancer using DNA methylated genes as diagnostic or prognostic biomarkers. ..
  18. Estrogen receptor beta protein:protein interactions following estrogen withdrawal
    NATASHA MOTT; Fiscal Year: 2013
    ..Overall, this proposal will reveal molecular mechanisms occurring during estrogen withdrawal that may alter the brain's receptivity to HT. ..
  19. Effects of Estradiol &Phytoestrogens on Stress Responsivity
    Pauline M Maki; Fiscal Year: 2013
    ..during the menopausal transition, and indirect data suggest a potential role for estrogen, particularly estrogen receptor beta, in mediating anxiety...
  20. Elucidating the mechanism of ERbeta in colon carcinogenesis
    CECILIA MARIE WILLIAMS; Fiscal Year: 2013
    ..b>Estrogen receptor beta (ER[unreadable]) is the predominant estrogen receptor in the human colonic epithelium;polymorphisms in ..
  21. Mechanisms underlie inverse gender discrepancy in ischemic protection
    Nian Qing Shi; Fiscal Year: 2010
    ....
  22. G protein-coupled estrogen receptor GPER and breast carcinogenesis
    Eric R Prossnitz; Fiscal Year: 2013
    ..Further development of this antagonist could lead to a new drug for the treatment of GPER-expressing breast tumors. ..
  23. Estrogen Receptor Beta Regulation of Mandibular Condylar Growth
    Sunil Wadhwa; Fiscal Year: 2013
    ..inhibition of mechanical loading-induced periosteal bone formation and axial skeletal growth requires estrogen receptor beta (ER[unreadable])...
  24. Estrogen Receptor-beta phytoSERMs for Management of Menopause and Memory Decline
    Lon S Schneider; Fiscal Year: 2012
    ..We have developed a formulation of phytoestrogenic molecules, that we term PhytoSERMs, which targets estrogen receptor beta. This study will determine the best dose, safety and tolerance of PhytoSERMs in peri to menopausal women ..
  25. Identification of ERalpha/ERbeta Heterodimer-specific Ligands by HTS
    Wei Xu; Fiscal Year: 2010
    ..Here we propose two-step high throughput screenings for identification of ER?/ER? heterodimer specific ligands. ..
  26. The Efficacy and Safety of a Selective Estrogen Receptor Beta agonist (LY500307)
    Alan Breier; Fiscal Year: 2013
    ..Selective Estrogen Receptor Beta (ER beta) agonists are a new class of treatments that are relatively free of estrogen's primary side ..
  27. The Role of Estrogen Receptor-Beta on Human Fetoplacental Vasculature
    Emily J Su; Fiscal Year: 2012
    ....
  28. RADIOPHARMACEUTICALS FOR BREAST TUMOR IMAGING & THERAPY
    John Katzenellenbogen; Fiscal Year: 2006
    ..These investigations should lead to substantial advances in the availability of diagnostic imaging gents for ER+ tumors and ER subtype- selective imaging agents, to the evaluation in vivo of radiotherapeutic ER ligands. ..
  29. ASTROCYTE-NEURON INTERACTIONS AND GNRH NEURONAL FUNCTION
    Darrell Brann; Fiscal Year: 2005
    ....
  30. Transgenic Models of Estrogen Receptor Activity in Bone
    Joseph Alexander; Fiscal Year: 2004
    ..abstract_text> ..
  31. ER beta selective agonist coronary protection-menopause
    R Hermsmeyer; Fiscal Year: 2005
    ..of rhesus monkeys in vivo to further test, and develop toward approval as a drug for human use, a novel estrogen receptor beta (ERbeta or ERb) selective (over ERalpha or ERa) agonist that is hypothesized to be effective for ..
  32. CHEMOPREVENTION OF MAMMARY TUMORS BY TAMOXIFEN AND SOY
    Andreas Constantinou; Fiscal Year: 2002
    ..2) Identify the mechanism of the anticipated additive/synergistic chemopreventive effect between tamoxifen and the active soy component. ..
  33. Phytoestrogens as an alternative treatment for MS
    Larry Sherman; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  34. Estrogen Receptors and Maintenance of Lens Transparency
    Vicki Davis; Fiscal Year: 2005
    ..This study will provide the gateway for future studies to investigate how exposure to various estrogens influence risk of age-related cataracts and the potential of estrogens as a therapy for cataract prevention. ..
  35. Mechanism(s)of antitumor action of tamoxifen and soy
    Andreas Constantinou; Fiscal Year: 2003
    ..This study will systematically explore their interactions to determine their safety and efficacy. ..
  36. MOLECULAR ASSAY FOR ESTROGEN RECEPTORS IN BREAST TUMORS
    Indira Poola; Fiscal Year: 2002
    ..Such outcomes will be significant for the breast cancer patients who are resistant or acquire resistance to anti-estrogen therapies. ..
  37. Phytoestrogen and Antioxidant Regulation of Prostate Cancer
    Dennis Lubahn; Fiscal Year: 2009
    ..These studies will provide fundamental insights into prostate tumor biology, and assess the role of these botanicals in modifying the incidence and progression of prostate tumors in humans. ..
  38. Interferon and Raloxifene Effects on Cancer Cells
    CHERYL ROSENFELD; Fiscal Year: 2007
    ..The University is in the process of developing a Comparative Oncology Program. The campus provides a rich mix of disciplines and a collaborative environment, in which Dr. Rosenfeld is expected to continue to thrive. ..
  39. EPIDEMIOLOGY OF MENOPAUSE AND DEMENTIA IN DOWN SYNDROME
    Nicole Schupf; Fiscal Year: 2009
    ..The proposed studies will clarify biological mechanisms relating variations in estrogen to the development of AD. ..
  40. Xenoestrogens: Genomic and Non-genomic Mechanisms
    Nira Ben Jonathan; Fiscal Year: 2006
    ..The results of these studies should provide much needed experimental foundation for assessing the vulnerability of the pituitary gland to insults by endocrine disruptors. ..
  41. Effects of Dietary Soy on Biomarkers in Prostate Cancer
    J Cline; Fiscal Year: 2004
    ..in prostatic tissue, and may have selective activity in the prostate because of their affinity for estrogen receptor beta, which is abundant in prostatic epithelium...
  42. SYNERGY BETWEEN SSRIS AND OVARIAN HORMONES
    NANCY MUMA; Fiscal Year: 2009
    ..The proposed studies may lead to novel targets for medications which affect the regulation of RGSZ-1 to treat women who suffer from hot flashes and mood disorders during menopause ..
  43. Estrogen Receptor Beta Regulation of the GnRH Neuron
    JENNIFER MAMMEN; Fiscal Year: 2009
    ..The goal of this research is to study the regulatory effects of estrogen, as mediated by estrogen receptor beta (ERbeta) in GnRH neurons, where this is the predominant isoform...
  44. Effects of dietary phytoestrogens on the aging brain
    Cynthia Corbitt; Fiscal Year: 2006
    ..For specific aim 2, end points include morphological measures (size of infarct) and number of cells with ischemia-induced damage in regions surrounding the infarct. ..
  45. NOVEL FLUORESCENT ESTROGEN RECEPTOR LIGAND BINDING ASSAY
    Robert Lowery; Fiscal Year: 1999
    ..In Phase III, PanVera will continue and expand commercialization of each assay through its comprehensive distribution network and pharmaceutical alliances. ..
  46. REGULATION OF CYCLOOXGENASE GENES IN DEVELOPING LUNG
    Philip Shaul; Fiscal Year: 2003
    ..These studies will provide fundamental new information about the regulation of pulmonary PGI/2 synthesis in the perinatal period, and about the roles of E/2 and ERs in vascular biology. ..
  47. MOLECULAR MECHANISMS OF ESTROGENS VASCULAR ACTIONS
    Kenneth Clark; Fiscal Year: 2003
    ..abstract_text> ..
  48. ER beta selective agonist coronary protection--menopause
    R Hermsmeyer; Fiscal Year: 2003
    ..I project is to test and develop, using primate coronary artery vascular muscle cells in vitro, a novel estrogen receptor beta (ERbeta) selective (over ERalpha) agonist that is highly effective for protecting coronary arteries ..
  49. Bile Acid and Estrogen Receptors in Colon Cancer
    Steven Kliewer; Fiscal Year: 2009
    ..and the anti- carcinogenic actions of estrogens are mediated through the bile acid receptor FXR and the estrogen receptor beta (ERbeta), respectively...
  50. METABOLIC EFFECTS OF THYROID HORMONE
    Herbert Samuels; Fiscal Year: 2007
    ..abstract_text> ..
  51. Effects of smoking on ERb and AHR pathway in human lung
    Radoslav Goldman; Fiscal Year: 2004
    ..Recently, estrogen receptor beta (ERb) was discovered to be expressed in human lung tissue and possibly absent in cancerous tissue...
  52. Studies of Estrogen Receptors in Autoimmunity
    WAEL JARJOUR; Fiscal Year: 2006
    ..abstract_text> ..
  53. BEHAVIORAL REGULATION OF NEUROENDOCRINE CELLS
    EMILIE RISSMAN; Fiscal Year: 2005
    ..receptors in activation of sexual behavior the PI has obtained several additional KO mice; including the estrogen receptor beta knockout and Tfm mice (androgen receptor knockouts)...
  54. Estrogen Receptor Beta Pharmacology in the Prostate
    DANIEL FRIGO; Fiscal Year: 2007
    ..Aim 2. Validation and characterization of ERbeta-interacting proteins in mammalian cells. Aim 3. Evaluation of the biological consequences of differential ERbeta-cofactor recruitment in androgen-responsive prostate cell lines. ..
  55. ESTROGEN RECEPTOR-BETA PROTEIN IN CANCER DIAGNOSIS
    ROBERT CHRISTY; Fiscal Year: 2001
    ..PROPOSED COMMERCIAL APPLICATION: The production of monoclonal antibodies against the Estrogen Receptor Beta isoforms will provide researchers and clinicians important reagents to determine the mechanisms of action ..
  56. Retrospective validation of putative breast cancer predictive molecular markers
    Indira Poola; Fiscal Year: 2008
    ..Detection at the precancerous stage and treatment could lead to fewer incidences of breast cancer and deaths from it. [unreadable] [unreadable] [unreadable]..
  57. ESTROGEN IMPRINTING OF PROSTATE GLAND VIA METHYLATON
    Gail Prins; Fiscal Year: 2005
    ....
  58. Development Estrogenization of the Rat Prostate Gland
    Gail S Prins; Fiscal Year: 2010
    ..Results will further define the mechanisms of estrogen's actions on the prostate gland during early development and lead to a better understanding of the hormonal and developmental basis for abnormal prostate growth with aging...
  59. Estrogen, Metabolism, Menopause, and Health Outcomes
    MaryFran Sowers; Fiscal Year: 2006
    ..This is a unique opportunity to prospectively integrate lifestyle elements with measures of hormone metabolism pathways into a comprehensive examination of multiple human health effects. ..
  60. Multidisciplinary Program in Female and Male Reproduction
    EUGENE ALBRECHT; Fiscal Year: 2008
    ..The discoveries obtained in the baboon primate model are expected to translate to the human to advance knowledge of human reproductive biology. [unreadable] [unreadable]..
  61. ALKYL PCDFS--INHIBITION OF MAMMARY CANCER
    Stephen Safe; Fiscal Year: 2001
    ..Thus the proposed studies will define a new mechanism-based class of antiestrogens that can be used alone or in combination with tamoxifen for treatment of breast and endometrial cancer. ..
  62. Coactivation of Estrogen Receptor alpha/Sp1
    Stephen Safe; Fiscal Year: 2006
    ..abstract_text> ..