estrogen receptor alpha

Summary

Summary: One of the ESTROGEN RECEPTORS that has marked affinity for ESTRADIOL. Its expression and function differs from, and in some ways opposes, ESTROGEN RECEPTOR BETA.

Top Publications

  1. pmc An oestrogen-receptor-alpha-bound human chromatin interactome
    Melissa J Fullwood
    Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore 138672
    Nature 462:58-64. 2009
  2. ncbi Estrogen receptor-alpha directs ordered, cyclical, and combinatorial recruitment of cofactors on a natural target promoter
    Raphaël Métivier
    European Molecular Biology Laboratory, Meyerhofstrasse 1, D 69117 Heidelberg, Germany
    Cell 115:751-63. 2003
  3. pmc FoxA1 translates epigenetic signatures into enhancer-driven lineage-specific transcription
    Mathieu Lupien
    Division of Molecular and Cellular Oncology, Department of Medical Oncology, Dana Farber Cancer Institute and Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Cell 132:958-70. 2008
  4. pmc ChIP-Seq of ERalpha and RNA polymerase II defines genes differentially responding to ligands
    Willem Jan Welboren
    Department of Molecular Biology, Faculty of Science, Nijmegen Centre for Molecular Life Sciences, Radboud University, Nijmegen, The Netherlands
    EMBO J 28:1418-28. 2009
  5. pmc FOXA1 is a key determinant of estrogen receptor function and endocrine response
    Antoni Hurtado
    Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Cambridge, UK
    Nat Genet 43:27-33. 2011
  6. ncbi A transmembrane intracellular estrogen receptor mediates rapid cell signaling
    Chetana M Revankar
    Department of Cell Biology and Physiology, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA
    Science 307:1625-30. 2005
  7. pmc Genome-wide association study identifies a new breast cancer susceptibility locus at 6q25.1
    Wei Zheng
    Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Nat Genet 41:324-8. 2009
  8. pmc Increased adipose tissue in male and female estrogen receptor-alpha knockout mice
    P A Heine
    Departments of Veterinary Biosciences and Kinesiology, University of Illinois, Urbana, IL 61802, USA
    Proc Natl Acad Sci U S A 97:12729-34. 2000
  9. pmc A rapid, extensive, and transient transcriptional response to estrogen signaling in breast cancer cells
    Nasun Hah
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA
    Cell 145:622-34. 2011
  10. pmc Cellular reprogramming by the conjoint action of ERα, FOXA1, and GATA3 to a ligand-inducible growth state
    Say Li Kong
    Cancer Biology and Pharmacology 2, Genome Institute of Singapore, Singapore
    Mol Syst Biol 7:526. 2011

Detail Information

Publications333 found, 100 shown here

  1. pmc An oestrogen-receptor-alpha-bound human chromatin interactome
    Melissa J Fullwood
    Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore 138672
    Nature 462:58-64. 2009
    ..We propose that chromatin interactions constitute a primary mechanism for regulating transcription in mammalian genomes...
  2. ncbi Estrogen receptor-alpha directs ordered, cyclical, and combinatorial recruitment of cofactors on a natural target promoter
    Raphaël Métivier
    European Molecular Biology Laboratory, Meyerhofstrasse 1, D 69117 Heidelberg, Germany
    Cell 115:751-63. 2003
    ....
  3. pmc FoxA1 translates epigenetic signatures into enhancer-driven lineage-specific transcription
    Mathieu Lupien
    Division of Molecular and Cellular Oncology, Department of Medical Oncology, Dana Farber Cancer Institute and Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Cell 132:958-70. 2008
    ..FoxA1 translates this epigenetic signature into changes in chromatin structure thereby establishing lineage-specific transcriptional enhancers and programs...
  4. pmc ChIP-Seq of ERalpha and RNA polymerase II defines genes differentially responding to ligands
    Willem Jan Welboren
    Department of Molecular Biology, Faculty of Science, Nijmegen Centre for Molecular Life Sciences, Radboud University, Nijmegen, The Netherlands
    EMBO J 28:1418-28. 2009
    ..Furthermore, our data identify genes preferentially regulated by tamoxifen but not by E2 or fulvestrant. Thus (partial) antagonist loaded ERalpha acts mechanistically different on E2-activated and E2-repressed genes...
  5. pmc FOXA1 is a key determinant of estrogen receptor function and endocrine response
    Antoni Hurtado
    Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Cambridge, UK
    Nat Genet 43:27-33. 2011
    ..Expression of FOXA1 in non-breast cancer cells can alter ER binding and function. As such, FOXA1 is a major determinant of estrogen-ER activity and endocrine response in breast cancer cells...
  6. ncbi A transmembrane intracellular estrogen receptor mediates rapid cell signaling
    Chetana M Revankar
    Department of Cell Biology and Physiology, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA
    Science 307:1625-30. 2005
    ..Thus, GPR30 represents an intracellular transmembrane estrogen receptor that may contribute to normal estrogen physiology as well as pathophysiology...
  7. pmc Genome-wide association study identifies a new breast cancer susceptibility locus at 6q25.1
    Wei Zheng
    Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Nat Genet 41:324-8. 2009
    ..SNP rs2046210 at 6q25.1, located upstream of the gene encoding estrogen receptor alpha (ESR1), showed strong and consistent association with breast cancer across all three stages...
  8. pmc Increased adipose tissue in male and female estrogen receptor-alpha knockout mice
    P A Heine
    Departments of Veterinary Biosciences and Kinesiology, University of Illinois, Urbana, IL 61802, USA
    Proc Natl Acad Sci U S A 97:12729-34. 2000
    ..These results are evidence that estrogen/ERalpha signaling is critical in female and male WAT; obesity in alphaERKO males involves a mechanism of reduced energy expenditure rather than increased energy intake...
  9. pmc A rapid, extensive, and transient transcriptional response to estrogen signaling in breast cancer cells
    Nasun Hah
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA
    Cell 145:622-34. 2011
    ..Collectively, our results provide the most comprehensive measurement of the primary and immediate estrogen effects to date and a resource for understanding rapid signal-dependent transcription in other systems...
  10. pmc Cellular reprogramming by the conjoint action of ERα, FOXA1, and GATA3 to a ligand-inducible growth state
    Say Li Kong
    Cancer Biology and Pharmacology 2, Genome Institute of Singapore, Singapore
    Mol Syst Biol 7:526. 2011
    ..Cumulatively, these results suggest that all the enhanceosome components comprising ERα, FOXA1, and GATA3 are necessary for the full repertoire of cancer-associated effects of the ERα...
  11. pmc A CTCF-independent role for cohesin in tissue-specific transcription
    Dominic Schmidt
    Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Cambridge CB2 0RE, United Kingdom
    Genome Res 20:578-88. 2010
    ..in human breast cancer cells (MCF-7), we discovered thousands of genomic sites that share cohesin and estrogen receptor alpha (ER) yet lack CTCF binding...
  12. pmc MicroRNA cluster 221-222 and estrogen receptor alpha interactions in breast cancer
    Gianpiero Di Leva
    Department of Molecular Virology, Immunology and Medical Genetics and Comprehensive Cancer Center, Ohio State University, 460 West, 12th Ave, Columbus, OH 43210, USA
    J Natl Cancer Inst 102:706-21. 2010
    Several lines of evidence have suggested that estrogen receptor alpha (ERalpha)-negative breast tumors, which are highly aggressive and nonresponsive to hormonal therapy, arise from ERalpha-positive precursors through different molecular ..
  13. pmc Aryl hydrocarbon receptor-mediated transcription: ligand-dependent recruitment of estrogen receptor alpha to 2,3,7,8-tetrachlorodibenzo-p-dioxin-responsive promoters
    Jason Matthews
    Department of Biosciences at Novum, Karolinska Institutet, Novum 14157, Sweden
    Mol Cell Biol 25:5317-28. 2005
    ..Interestingly, estrogen receptor alpha (ERalpha) displayed a TCDD- and time-dependent recruitment to the CYP1A1 promoter, which was increased by ..
  14. ncbi Relevance of breast cancer cell lines as models for breast tumours: an update
    Marc Lacroix
    Laboratoire Jean Claude Heuson de Cancérologie Mammaire, Institut Jules Bordet, Universite Libre de Bruxelles, Bruxelles, Belgium
    Breast Cancer Res Treat 83:249-89. 2004
    ..Investigations on additional specific lines are expected to improve our knowledge of BCC and of the dialogue that these maintain with their surrounding normal cells in vivo...
  15. pmc AP-2γ regulates oestrogen receptor-mediated long-range chromatin interaction and gene transcription
    Si Kee Tan
    Cancer Biology and Pharmacology, Genome Institute of Singapore, A STAR Agency for Science, Technology and Research, Singapore
    EMBO J 30:2569-81. 2011
    ..Finally, we show that most ERBS associated with long-range chromatin interactions are colocalized with AP-2γ and FoxA1. Together, our results suggest AP-2γ is a novel collaborative factor in ERα-mediated transcription...
  16. pmc Oestrogen receptor-co-factor-chromatin specificity in the transcriptional regulation of breast cancer
    Wilbert Zwart
    The Netherlands Cancer Institute, Amsterdam, The Netherlands
    EMBO J 30:4764-76. 2011
    ..By generating a robust and global view of co-factor-binding properties, we discover new levels of co-regulator complexity, but also reveal specific gene networks that may influence endocrine response...
  17. pmc MicroRNA-221/222 negatively regulates estrogen receptor alpha and is associated with tamoxifen resistance in breast cancer
    Jian Jun Zhao
    H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida 33612, USA
    J Biol Chem 283:31079-86. 2008
    A search for regulators of estrogen receptor alpha (ERalpha) expression has yielded a set of microRNAs (miRNAs) for which expression is specifically elevated in ERalpha-negative breast cancer...
  18. ncbi The structural basis of estrogen receptor/coactivator recognition and the antagonism of this interaction by tamoxifen
    A K Shiau
    Howard Hughes Medical Institute and the Department of Biochemistry and Biophysics, University of California at San Francisco, 94143 0448, USA
    Cell 95:927-37. 1998
    ..Here we report the crystal structure of the human estrogen receptor alpha (hER alpha) ligand-binding domain (LBD) bound to both the agonist diethylstilbestrol (DES) and a peptide ..
  19. ncbi The different roles of ER subtypes in cancer biology and therapy
    Christoforos Thomas
    Center for Nuclear Receptors and Cell Signalling, Department of Biology and Biochemistry, University of Houston, Houston 77204, Texas, USA
    Nat Rev Cancer 11:597-608. 2011
    ..The changes in the bioavailability of ERs in tumours, together with their specific biological functions, promote the selective restoration of their activity as one of the major therapeutic approaches for hormone-dependent cancers...
  20. ncbi Positive cross-regulatory loop ties GATA-3 to estrogen receptor alpha expression in breast cancer
    Jerome Eeckhoute
    Division of Molecular and Cellular Oncology, Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Cancer Res 67:6477-83. 2007
    ..GATA-3 is required for normal mammary gland development, and its expression is highly correlated with estrogen receptor alpha (ER alpha) in human breast tumors...
  21. pmc Genomic antagonism between retinoic acid and estrogen signaling in breast cancer
    Sujun Hua
    Institute for Genomics and Systems Biology and Department of Human Genetics, The University of Chicago, 920 East 58th Street, Chicago, IL 60637, USA
    Cell 137:1259-71. 2009
    ..We found that RAR binding throughout the genome is highly coincident with estrogen receptor alpha (ERalpha) binding, resulting in a widespread crosstalk of RA and estrogen signaling to antagonistically ..
  22. ncbi MicroRNAs link estrogen receptor alpha status and Dicer levels in breast cancer
    Dawn R Cochrane
    Department of Pathology, University of Colorado Denver, Mail Stop 8104, P O Box 6511, Aurora, CO 80045, USA
    Horm Cancer 1:306-19. 2010
    ....
  23. pmc Unique roles of p160 coactivators for regulation of breast cancer cell proliferation and estrogen receptor-alpha transcriptional activity
    Sudipan Karmakar
    Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Endocrinology 150:1588-96. 2009
    ....
  24. pmc Estrogen receptor alpha controls a gene network in luminal-like breast cancer cells comprising multiple transcription factors and microRNAs
    Luigi Cicatiello
    Department of General Pathology, Second University of Naples, Napoli, Italy
    Am J Pathol 176:2113-30. 2010
    Luminal-like breast tumor cells express estrogen receptor alpha (ERalpha), a member of the nuclear receptor family of ligand-activated transcription factors that controls their proliferation, survival, and functional status...
  25. pmc FOXA1 is an essential determinant of ERalpha expression and mammary ductal morphogenesis
    Gina M Bernardo
    Department of Pharmacology, Case Western Reserve University School of Medicine, 10900 Euclid Avenue, Cleveland, OH 44106, USA
    Development 137:2045-54. 2010
    FOXA1, estrogen receptor alpha (ERalpha) and GATA3 independently predict favorable outcome in breast cancer patients, and their expression correlates with a differentiated, luminal tumor subtype...
  26. pmc The histone demethylase JMJD2B is regulated by estrogen receptor alpha and hypoxia, and is a key mediator of estrogen induced growth
    Jun Yang
    Growth Factor Group, Cancer Research UK, Molecular Oncology Laboratories, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Headington, United Kingdom
    Cancer Res 70:6456-66. 2010
    b>Estrogen receptor alpha (ERalpha) plays an important role in breast cancer...
  27. ncbi Dioxin receptor is a ligand-dependent E3 ubiquitin ligase
    Fumiaki Ohtake
    ERATO, Japan Science and Technology Agency, 4 1 8 Honcho, Kawaguchi, Saitama 332 0012, Japan
    Nature 446:562-6. 2007
    ....
  28. ncbi Estrogen receptors and the metabolic network
    Rodrigo P A Barros
    Center for Nuclear Receptors and Cell Signaling, Department of Cell Biology and Biochemistry, University of Houston, Houston, TX 77004, USA
    Cell Metab 14:289-99. 2011
    ..Imbalance of ERα/ERβ ratio in this "metabolic network" may lead to the metabolic syndrome...
  29. ncbi ER alpha-AHR-ARNT protein-protein interactions mediate estradiol-dependent transrepression of dioxin-inducible gene transcription
    Timothy V Beischlag
    Center for Molecular Toxicology and Carcinogenesis and Department of Veterinary Sciences, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
    J Biol Chem 280:21607-11. 2005
    ..Taken together these data support a role for ER-mediated transrepression of AHR-dependent gene regulation...
  30. pmc The estrogen receptor-alpha-induced microRNA signature regulates itself and its transcriptional response
    Leandro Castellano
    Department of Oncology, Cyclotron Building, Hammersmith Hospital Campus, Imperial College, Du Cane Road, London W12 0NN, United Kingdom
    Proc Natl Acad Sci U S A 106:15732-7. 2009
    ..We propose that ERalpha, c-MYC, and miRNA transcriptional programs invoke a sophisticated network of interactions able to provide the wide range of coordinated cellular responses to estrogen...
  31. ncbi Effect of single and compound knockouts of estrogen receptors alpha (ERalpha) and beta (ERbeta) on mouse reproductive phenotypes
    S Dupont
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, College de France, BP 163, France
    Development 127:4277-91. 2000
    ..Our results also show that cell proliferation in the prostate and urinary bladder of old ERbetaKO and ERalphabetaKO males is apparently normal...
  32. ncbi Phosphatidylinositol 3-kinase/AKT-mediated activation of estrogen receptor alpha: a new model for anti-estrogen resistance
    R A Campbell
    Department of Surgery, Indiana University School of Medicine, Indianapolis 46202, USA
    J Biol Chem 276:9817-24. 2001
    ..Taken together, these results define a molecular link between activation of the PI 3-kinase/AKT survival pathways, hormone-independent activation of ERalpha, and inhibition of tamoxifen-induced apoptotic regression...
  33. ncbi Epigenetically deregulated microRNA-375 is involved in a positive feedback loop with estrogen receptor alpha in breast cancer cells
    Pedro de Souza Rocha Simonini
    Division of Functional Genome Analysis, Helmholtz University Young Investigator Group Molecular RNA Biology and Cancer, German Cancer Research Center DKFZ and Institute of Pathology, University of Heidelberg, Heidelberg, Germany
    Cancer Res 70:9175-84. 2010
    ..Additionally, we found that RASD1 negatively regulates ERα expression. Our findings define a forward feedback pathway in control of ERα expression, highlighting new strategies to treat ERα-positive invasive breast tumors...
  34. pmc A cell-type-specific transcriptional network required for estrogen regulation of cyclin D1 and cell cycle progression in breast cancer
    Jerome Eeckhoute
    Division of Molecular and Cellular Oncology, Department of Medical Oncology, Dana Farber Cancer Institute and Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Genes Dev 20:2513-26. 2006
    Estrogen stimulates the proliferation of the most common type of human breast cancer that expresses estrogen receptor alpha (ERalpha) through the activation of the cyclin D1 (CCND1) oncogene...
  35. pmc Estrogen receptor (ER) beta, a modulator of ERalpha in the uterus
    Z Weihua
    Department of Medical Nutrition, Karolinska Institute, Novum, S 141 86 Huddinge, Sweden
    Proc Natl Acad Sci U S A 97:5936-41. 2000
    ....
  36. ncbi Estrogen receptor (ER) mRNA and ER-related gene expression in breast cancers that are 1% to 10% ER-positive by immunohistochemistry
    Takayuki Iwamoto
    The University of Texas MD Anderson Cancer Center, Houston, TX 77230 1439, USA
    J Clin Oncol 30:729-34. 2012
    ....
  37. pmc PBX1 genomic pioneer function drives ERα signaling underlying progression in breast cancer
    Luca Magnani
    Norris Cotton Cancer Center, Dartmouth Medical School, Lebanon, New Hampshire, USA
    PLoS Genet 7:e1002368. 2011
    ..PBX1 is a TALE homeodomain protein involved in the development of different types of cancers. The estrogen receptor alpha (ERα) is central to the development of two-thirds of all breast cancers...
  38. ncbi Autoantibodies to estrogen receptor α interfere with T lymphocyte homeostasis and are associated with disease activity in systemic lupus erythematosus
    Tania Colasanti
    Istituto Superiore di Sanita, Rome, Italy, and San Raffaele Institute Sulmona, L Aquila, Italy
    Arthritis Rheum 64:778-87. 2012
    ....
  39. ncbi Development of subtype-selective oestrogen receptor-based therapeutics
    Stefan Nilsson
    Karo Bio AB, Novum, SE 141 57 Huddinge, Sweden
    Nat Rev Drug Discov 10:778-92. 2011
    ....
  40. pmc Selective mutations in estrogen receptor alpha D-domain alters nuclear translocation and non-estrogen response element gene regulatory mechanisms
    Katherine A Burns
    Receptor Biology, Laboratory of Reproductive and Developmental Toxicology, Protein Expression Core Facility, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    J Biol Chem 286:12640-9. 2011
    ..In addition, the properties of these ERα mutants will allow future studies to further dissect and characterize the three main ERα mechanisms of action and determine the mechanistic role each action has in estrogen hormone regulation...
  41. ncbi Phosphatidylinositol-3-OH Kinase (PI3K)/AKT2, activated in breast cancer, regulates and is induced by estrogen receptor alpha (ERalpha) via interaction between ERalpha and PI3K
    M Sun
    Department of Pathology and Programs of Molecular Oncology and Drug Discovery, University of South Florida College of Medicine and H Lee Moffitt Cancer Center, Tampa, Florida 33612, USA
    Cancer Res 61:5985-91. 2001
    ..The majority of the cases with the activation are estrogen receptor alpha (ERalpha) positive, which prompted us to examine whether AKT2 regulates ERalpha activity...
  42. pmc Involvement of estrogen receptor variant ER-alpha36, not GPR30, in nongenomic estrogen signaling
    Lianguo Kang
    Department of Medical Microbiology and Immunology, Creighton University Medical School, Omaha, Nebraska 68178, USA
    Mol Endocrinol 24:709-21. 2010
    ..The selective G protein-coupled receptor (GPR)30 agonist G1 actually interacts with ER-alpha36. Thus, the ER-alpha variant ER-alpha36, not GPR30, is involved in nongenomic estrogen signaling...
  43. pmc Global analysis of estrogen receptor beta binding to breast cancer cell genome reveals an extensive interplay with estrogen receptor alpha for target gene regulation
    Oli M V Grober
    Department of General Pathology, Second University of Naples, vico L, De Crecchio 7, 80138 Napoli, Italy
    BMC Genomics 12:36. 2011
    ..The identification of the genomic targets of ERβ in hormone-responsive BC cells is thus a critical step to elucidate the roles of this receptor in estrogen signaling and tumor cell biology...
  44. pmc Estrogen receptor alpha expression in podocytes mediates protection against apoptosis in-vitro and in-vivo
    Sebastian Kummer
    Department of General Pediatrics and Neonatology, University Children s Hospital Duesseldorf, Duesseldorf, Germany
    PLoS ONE 6:e27457. 2011
    ..This suggests critical influences of gender hormones on glomerular structure and function. We examined potential direct protective effects of estradiol on podocytes...
  45. ncbi Kisspeptin immunoreactive cells of the ovine preoptic area and arcuate nucleus co-express estrogen receptor alpha
    I Franceschini
    UMR 6175 INRA CNRS UniversityTours Haras Nationaux, IFR 135, 37380 Nouzilly, France
    Neurosci Lett 401:225-30. 2006
    ..The pattern of distribution of kp10 immunoreactivity in the hypothalamus suggests a role for kisspeptin in the estrogen-dependent regulation of GnRH and LH secretion in the ewe...
  46. ncbi Pyrazolo[1,5-a]pyrimidines: estrogen receptor ligands possessing estrogen receptor beta antagonist activity
    Dennis R Compton
    Department of Chemistry and Department of Molecular and Integrative Physiology, University of Illinois, 600 South Matthews Avenue, Urbana, Illinois 61801, USA
    J Med Chem 47:5872-93. 2004
    ....
  47. pmc Integrative model of genomic factors for determining binding site selection by estrogen receptor-α
    Roy Joseph
    Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore
    Mol Syst Biol 6:456. 2010
    ..These results suggest a definable interplay between sequence motifs and local chromatin in selecting TF binding...
  48. pmc Estradiol-regulated microRNAs control estradiol response in breast cancer cells
    Poornima Bhat-Nakshatri
    Department of Surgery, Indiana University School of Medicine, Indianapolis, IN, USA
    Nucleic Acids Res 37:4850-61. 2009
    Estradiol (E2) regulates gene expression at the transcriptional level by functioning as a ligand for estrogen receptor alpha (ERalpha) and estrogen receptor beta (ERbeta)...
  49. pmc Generation and reproductive phenotypes of mice lacking estrogen receptor beta
    J H Krege
    Department of Pathology, University of North Carolina, Chapel Hill, NC 27599 7525, USA
    Proc Natl Acad Sci U S A 95:15677-82. 1998
    ..We previously generated and studied knockout mice lacking estrogen receptor alpha and reported severe reproductive and behavioral phenotypes including complete infertility of both male ..
  50. ncbi Transient cyclical methylation of promoter DNA
    Sara Kangaspeska
    European Molecular Biology Laboratory, Meyerhofstrasse 1, D 69117 Heidelberg, Germany
    Nature 452:112-5. 2008
    ..This coincides with a low-level re-expression of ERalpha and of pS2 transcripts...
  51. ncbi Evidence that oestrogen receptor-alpha plays an important role in the regulation of glucose homeostasis in mice: insulin sensitivity in the liver
    G Bryzgalova
    Department of Molecular Medicine, Karolinska Hospital, Karolinska Institute, Stockholm, Sweden
    Diabetologia 49:588-97. 2006
    ..We used oestrogen receptor-alpha (ERalpha) knockout (ERKO) and receptor-beta (ERbeta) knockout (BERKO) mice to investigate the mechanism(s) behind the effects of oestrogens on glucose homeostasis...
  52. pmc Distinct hypothalamic neurons mediate estrogenic effects on energy homeostasis and reproduction
    Yong Xu
    Children s Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA
    Cell Metab 14:453-65. 2011
    ..These results indicate that estrogens act on distinct hypothalamic ERα neurons to regulate different aspects of energy homeostasis and reproduction...
  53. ncbi Molecular basis for estrogen receptor alpha deficiency in BRCA1-linked breast cancer
    Alison M Hosey
    Centre for Cancer Research and Cell Biology, Queen s University Belfast, 97 Lisburn Rd, Belfast, Northern Ireland, BT9 7BL, UK
    J Natl Cancer Inst 99:1683-94. 2007
    BRCA1-mutant breast tumors are typically estrogen receptor alpha (ER alpha) negative, whereas most sporadic tumors express wild-type BRCA1 and are ER alpha positive...
  54. pmc Genomic index of sensitivity to endocrine therapy for breast cancer
    W Fraser Symmans
    Department of Pathology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    J Clin Oncol 28:4111-9. 2010
    ..We hypothesize that measurement of gene expression related to estrogen receptor α (ER; gene name ESR1) within a breast cancer sample represents intrinsic tumoral sensitivity to adjuvant endocrine therapy...
  55. pmc Paracrine signaling through the epithelial estrogen receptor alpha is required for proliferation and morphogenesis in the mammary gland
    Sonia Mallepell
    National Center of Competence in Research Molecular Oncology, Swiss Institute for Experimental Cancer Research, 155 Chemin des Boveresses, CH 1066 Epalinges s Lausanne, Switzerland
    Proc Natl Acad Sci U S A 103:2196-201. 2006
    ..is a major regulator of postnatal mammary gland development and thought to exert its effects through estrogen receptor alpha (ERalpha) expressed in the mammary gland stroma and epithelium...
  56. pmc FOXA1: master of steroid receptor function in cancer
    Michael A Augello
    Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA
    EMBO J 30:3885-94. 2011
    ..The present review article will focus on the mechanisms, consequence, and clinical relevance of FOXA1-mediated steroid nuclear receptor signalling in human malignancy...
  57. pmc The origins of estrogen receptor alpha-positive and estrogen receptor alpha-negative human breast cancer
    D Craig Allred
    Breast Center Department of Pathology, Baylor College of Medicine, Houston, Texas, USA
    Breast Cancer Res 6:240-5. 2004
    ..Their success, however, is often temporary and limited to a subset of patients whose tumors express estrogen receptor alpha (ER). The therapies are entirely ineffective in ER-negative disease...
  58. ncbi Estrogen receptors: therapies targeted to receptor subtypes
    S Nilsson
    Karo Bio AB, Novum, Huddinge, Sweden
    Clin Pharmacol Ther 89:44-55. 2011
    ..It must be stated, however, that appropriate clinical studies are necessary to validate these compounds as agents for the prevention and treatment of diseases...
  59. ncbi International Union of Pharmacology. LXIV. Estrogen receptors
    Karin Dahlman-Wright
    Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden
    Pharmacol Rev 58:773-81. 2006
  60. ncbi Structure-function relationship of estrogen receptor alpha and beta: impact on human health
    Paolo Ascenzi
    Department of Biology, University Roma Tre, Viale Guglielmo Marconi 446, I 00146 Roma, Italy
    Mol Aspects Med 27:299-402. 2006
    ....
  61. ncbi Cross-talk between notch and the estrogen receptor in breast cancer suggests novel therapeutic approaches
    Paola Rizzo
    Breast Cancer Program and Skin Cancer Program, Cardinal Bernardin Cancer Center, Loyola University Chicago
    Cancer Res 68:5226-35. 2008
    ..Notch-induced transcriptional activity did not correlate with Notch receptor levels and was highest in estrogen receptor alpha-negative (ERalpha(-)), Her2/Neu nonoverexpressing cells...
  62. pmc Variants in the estrogen receptor alpha gene and its mRNA contribute to risk for schizophrenia
    Cynthia Shannon Weickert
    MiNDS Unit, Section on Neuropathology, GCAP, NIMH, NIH, Bethesda, MD 20892, USA
    Hum Mol Genet 17:2293-309. 2008
    ..We hypothesized that the variation in the estrogen receptor alpha (ESR1) gene and cortical ESR1 mRNA is associated with schizophrenia...
  63. ncbi Let-7 family miRNAs regulate estrogen receptor alpha signaling in estrogen receptor positive breast cancer
    Yingchun Zhao
    Genomics and Functional Proteomics Laboratories, Osteoporosis Research Center, Creighton University Medical Center, 601 N 30th St, Suite 6730, Omaha, NE 68131, USA
    Breast Cancer Res Treat 127:69-80. 2011
    ..we performed bioinformatics analysis and found that let-7 miRNA sequences match sequence in the 3'-UTR of estrogen receptor alpha (ER-α), suggesting ER-α may be a target of let-7, which was further confirmed by a number of ..
  64. pmc Estrogen attenuates ischemic oxidative damage via an estrogen receptor alpha-mediated inhibition of NADPH oxidase activation
    Quan Guang Zhang
    Developmental Neurobiology Program, Institute of Molecular Medicine and Genetics, and Department of Neurology, Medical College of Georgia, Augusta, GA 30912, USA
    J Neurosci 29:13823-36. 2009
    ..production in hippocampal CA1 pyramidal neurons after stroke, an effect mediated by extranuclear estrogen receptor alpha (ERalpha)-mediated nongenomic signaling, involving Akt activation and subsequent phosphorylation/..
  65. ncbi GREB 1 is a critical regulator of hormone dependent breast cancer growth
    James M Rae
    Department of Internal Medicine, Division of Hematology and Oncology, University of Michigan Medical Center, 1150 W Medical Center Drive, Ann Arbor, MI 48109 0612, USA
    Breast Cancer Res Treat 92:141-9. 2005
    ..stimulated breast cancer growth, DNA microarray based gene expression profiles were generated from three estrogen receptor alpha (ER alpha) positive breast cancer cell lines grown under multiple stimulatory and inhibitory conditions.
  66. ncbi G protein-coupled receptor 30 (GPR30) mediates gene expression changes and growth response to 17beta-estradiol and selective GPR30 ligand G-1 in ovarian cancer cells
    Lidia Albanito
    Departments of Pharmaco Biology and Cell Biology, University of Calabria, 87030 Rende Cosenza, Italy
    Cancer Res 67:1859-66. 2007
    ..Whether estrogen receptor alpha (ERalpha) also contributes to GPR30/EGFR signaling is less understood...
  67. ncbi A differentially methylated single CpG-site is correlated with estrogen receptor alpha transcription
    Rainer W Fürst
    Physiology Weihenstephan, Technische Universitat Munchen, 85354 Freising Weihenstephan, Germany
    J Steroid Biochem Mol Biol 130:96-104. 2012
    DNA methylation of the promoter region of estrogen receptor alpha (ESR1) is recognized as an epigenetic mechanism that regulates its mRNA abundance...
  68. pmc Structural plasticity in the oestrogen receptor ligand-binding domain
    Kendall W Nettles
    Department of Cancer Biology, The Scripps Research Institute, 5353 Parkside Drive, Jupiter, Florida 33458, USA
    EMBO Rep 8:563-8. 2007
    ..This work shows that steroid hormone receptors can interact with a wider array of pharmacophores than previously thought through structural plasticity in the ligand-binding pocket...
  69. ncbi Estrogen receptor alpha mediates progestin-induced mammary tumor growth by interacting with progesterone receptors at the cyclin D1/MYC promoters
    Sebastián Giulianelli
    Institute of Experimental Biology and Medicine, IBYME CONICET, Buenos Aires, Argentina
    Cancer Res 72:2416-27. 2012
    ..Moreover, it remains unclear whether cytoplasmic interactions between the progesterone receptor (PR) and estrogen receptor alpha (ERα) are required for PR activation...
  70. pmc TRIM24 links a non-canonical histone signature to breast cancer
    Wen Wei Tsai
    Department of Biochemistry and Molecular Biology, Program in Genes and Development, Graduate School of Biomedical Sciences, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Nature 468:927-32. 2010
    ..The PHD-Bromo of TRIM24 provides a structural rationale for chromatin activation through a non-canonical histone signature, establishing a new route by which chromatin readers may influence cancer pathogenesis...
  71. ncbi Oestrogen-receptor-mediated transcription and the influence of co-factors and chromatin state
    Kelly A Green
    Cancer Research UK Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge, UK
    Nat Rev Cancer 7:713-22. 2007
    ....
  72. pmc Integration of estrogen and Wnt signaling circuits by the polycomb group protein EZH2 in breast cancer cells
    Bin Shi
    Department of Biochemistry and Molecular Biology, Peking University Health Science Center, 38 Xue Yuan Road, Beijing 100083, China
    Mol Cell Biol 27:5105-19. 2007
    ..We demonstrated that EZH2 physically interacts directly with estrogen receptor alpha and beta-catenin, thus connecting the estrogen and Wnt signaling circuitries, functionally enhances gene ..
  73. pmc Estrogen receptor alpha expression in ovarian cancer predicts longer overall survival
    Agnieszka Halon
    Department of Pathomorphology, Wroclaw Medical University, Wroclaw, Poland
    Pathol Oncol Res 17:511-8. 2011
    Estrogen as a potential factor of ovarian carcinogenesis, acts via two nuclear receptors, estrogen receptor alpha (ERα) and estrogen receptor beta (ERβ), but the cellular signal pathways involved are not completely clear so far...
  74. ncbi Promoter methylation regulates estrogen receptor 2 in human endometrium and endometriosis
    Qing Xue
    Division of Reproductive Biology Research, Department of Obsterics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Biol Reprod 77:681-7. 2007
    ..These findings may be applied to a number of areas ranging from diagnosis to the treatment of endometriosis...
  75. pmc Genomic collaboration of estrogen receptor alpha and extracellular signal-regulated kinase 2 in regulating gene and proliferation programs
    Zeynep Madak-Erdogan
    University of Illinois, Department of Molecular and Integrative Physiology, 407 South Goodwin Ave, Urbana, IL 61801 3704, USA
    Mol Cell Biol 31:226-36. 2011
    ....
  76. ncbi Overexpression of histone deacetylase HDAC1 modulates breast cancer progression by negative regulation of estrogen receptor alpha
    Hideki Kawai
    Division of Experimental Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02115, USA
    Int J Cancer 107:353-8. 2003
    The interaction between 17beta-estradiol and estrogen receptor alpha (ER-alpha) plays an important role in breast carcinogenesis and breast cancer treatment...
  77. ncbi mTOR/S6K1 and MAPK/RSK signaling pathways coordinately regulate estrogen receptor alpha serine 167 phosphorylation
    Rachel L Yamnik
    Department of Biology, Stern College for Women of Yeshiva University, New York, NY 10016, USA
    FEBS Lett 584:124-8. 2010
    ..Estrogen-independent phosphorylation of estrogen receptor alpha, specifically on Ser167, is one of the contributing causes to development of resistance, and a prognostic ..
  78. ncbi PIK3CA mutations correlate with hormone receptors, node metastasis, and ERBB2, and are mutually exclusive with PTEN loss in human breast carcinoma
    Lao H Saal
    Integrated Program in Cellular, Molecular, and Biophysical Studies, Institute for Cancer Genetics, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Cancer Res 65:2554-9. 2005
    ..Thus, mutation of PIK3CA is frequent, occurs early in carcinoma development, and has prognostic and therapeutic implications...
  79. ncbi Activities of estrogen receptor alpha- and beta-selective ligands at diverse estrogen responsive gene sites mediating transactivation or transrepression
    William R Harrington
    Department of Molecular and Integrative Physiology, University of Illinois, 407 S Goodwin Avenue, 524 Burrill Hall, Urbana, IL 61801 3704, USA
    Mol Cell Endocrinol 206:13-22. 2003
    ....
  80. ncbi Hypomethylation-linked activation of PAX2 mediates tamoxifen-stimulated endometrial carcinogenesis
    Huijian Wu
    Department of Biochemistry and Molecular Biology, Peking University Health Science Center, Beijing 100083, China
    Nature 438:981-7. 2005
    ..Our experiments show that PAX2 is activated by oestrogen and tamoxifen in endometrial carcinomas but not in normal endometrium, and that this activation is associated with cancer-linked hypomethylation of the PAX2 promoter...
  81. pmc Estradiol downregulates miR-21 expression and increases miR-21 target gene expression in MCF-7 breast cancer cells
    Nalinie S Wickramasinghe
    Department of Biochemistry and Molecular Biology, Center for Genetics and Molecular Medicine, University of Louisville School of Medicine, Louisville, KY 40292, USA
    Nucleic Acids Res 37:2584-95. 2009
    Select changes in microRNA (miRNA) expression correlate with estrogen receptor alpha (ER alpha) expression in breast tumors...
  82. pmc Genome-wide analysis of estrogen receptor alpha DNA binding and tethering mechanisms identifies Runx1 as a novel tethering factor in receptor-mediated transcriptional activation
    Joshua D Stender
    University of Illinois, Department of Molecular and Integrative Physiology, 524 Burrill Hall, 407 South Goodwin Avenue, Urbana, IL 61801 3704, USA
    Mol Cell Biol 30:3943-55. 2010
    Nuclear receptor estrogen receptor alpha (ER alpha) controls the expression of hundreds of genes responsible for target cell phenotypic properties, but the relative importance of direct versus tethering mechanisms of DNA binding has not ..
  83. ncbi Association of estrogen receptor alpha polymorphisms with susceptibility to chronic hepatitis B virus infection
    Guohong Deng
    Department of Infectious Diseases, Southwest Hospital, Chongqing, China
    Hepatology 40:318-26. 2004
    Several studies have demonstrated that estrogen receptor alpha (ESR1) participates in the pathogenesis of persistent hepatitis B virus (HBV) infection...
  84. pmc Growth factor stimulation induces a distinct ER(alpha) cistrome underlying breast cancer endocrine resistance
    Mathieu Lupien
    Division of Molecular and Cellular Oncology, Department of Medical Oncology, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Genes Dev 24:2219-27. 2010
    ....
  85. pmc Loading-related regulation of gene expression in bone in the contexts of estrogen deficiency, lack of estrogen receptor alpha and disuse
    Gul Zaman
    Department of Veterinary Basic Sciences, The Royal Veterinary College, University of London, Royal College Street, London NW1 0TU, UK
    Bone 46:628-42. 2010
    ..in the tibia of female mice in the contexts of normality (WT), estrogen deficiency (WT-OVX), absence of estrogen receptor alpha (ERalpha(-/-)) and disuse due to sciatic neurectomy (WT-SN) were established by microarray...
  86. ncbi Identification, cloning, and expression of human estrogen receptor-alpha36, a novel variant of human estrogen receptor-alpha66
    Zhaoyi Wang
    Cancer Center, Creighton University, Omaha, NE 68178, USA
    Biochem Biophys Res Commun 336:1023-7. 2005
    ....
  87. pmc Plasma membrane estrogen receptors
    Ellis R Levin
    Division of Endocrinology, Veterans Affairs Medical Center, Long Beach, Long Beach, CA 90822, USA
    Trends Endocrinol Metab 20:477-82. 2009
    ..Such actions include prevention of vascular injury or cardiac hypertrophy, sexual behavior and pain perception mediated through the central nervous system, osteoblast survival, and fluid resorption in the colon...
  88. pmc A variant of estrogen receptor-{alpha}, hER-{alpha}36: transduction of estrogen- and antiestrogen-dependent membrane-initiated mitogenic signaling
    Zhaoyi Wang
    Cancer Center, Creighton University, 2500 California Plaza, Omaha, NE 68178, USA
    Proc Natl Acad Sci U S A 103:9063-8. 2006
    ....
  89. ncbi Estrogen regulates Snail and Slug in the down-regulation of E-cadherin and induces metastatic potential of ovarian cancer cells through estrogen receptor alpha
    Se Hyung Park
    Department of Obstetrics and Gynecology, University of British Columbia, 2H 30, 4490 Oak Street, Vancouver, British Columbia, Canada V6H 3V5
    Mol Endocrinol 22:2085-98. 2008
    ..Collectively, this study provides a compelling argument that estrogen can potentiate tumor progression by EMT induction and highlights the crucial role of ERalpha in ovarian tumorigenesis...
  90. ncbi Comparative distribution of estrogen receptor-alpha and -beta mRNA in the rat central nervous system
    P J Shughrue
    The Women s Health Research Institute, Wyeth Ayerst Research, Radnor, Pennsylvania 19087, USA
    J Comp Neurol 388:507-25. 1997
    ..In addition, this comparative study provides evidence that the region-specific expression of ER-alpha, ER-beta, or both may be important in determining the physiological responses of neuronal populations to estrogen action...
  91. ncbi Synergistic activation of functional estrogen receptor (ER)-alpha by DNA methyltransferase and histone deacetylase inhibition in human ER-alpha-negative breast cancer cells
    X Yang
    The Johns Hopkins Oncology Center, Johns Hopkins University, Baltimore, Maryland 21231, USA
    Cancer Res 61:7025-9. 2001
    ..These data suggest that the activities of both DNMT1 and HDAC are key regulators of methylation-mediated ER gene silencing...
  92. pmc Estrogenic activity of bisphenol A and 2,2-bis(p-hydroxyphenyl)-1,1,1-trichloroethane (HPTE) demonstrated in mouse uterine gene profiles
    Sylvia C Hewitt
    Receptor Biology Section, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA
    Environ Health Perspect 119:63-70. 2011
    ..Comparison of E2 uterine transcript profiles and those of other estrogenic chemicals of interest in vivo indicates mechanisms and activities of test compounds...
  93. pmc A positive feedback loop of ER-α36/EGFR promotes malignant growth of ER-negative breast cancer cells
    X T Zhang
    Department of Medical Microbiology and Immunology, Creighton University Medical School, Omaha, NE, USA
    Oncogene 30:770-80. 2011
    ....
  94. pmc GPR30 activation opposes estrogen-dependent uterine growth via inhibition of stromal ERK1/2 and estrogen receptor alpha (ERα) phosphorylation signals
    Fei Gao
    Division of Reproductive Sciences, The Perinatal Institute, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
    Endocrinology 152:1434-47. 2011
    ..Our work has uncovered a novel GPR30-regulated inhibitory event, which may be physiologically relevant in both normal and pathological situations to negatively balance ERα-dependent uterine growth regulatory functions induced by E2...
  95. ncbi Role of the oestrogen receptor (ESR1 PvuII and ESR1 325 C->G) and progesterone receptor (PROGINS) polymorphisms in genetic susceptibility to migraine in a North Indian population
    G Joshi
    Department of Genetics, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India
    Cephalalgia 30:311-20. 2010
    ..PROGINS polymorphism seems to play a protective role in genetic susceptibility to migraine in the North Indian population...
  96. ncbi Impact of estrogen receptor beta on gene networks regulated by estrogen receptor alpha in breast cancer cells
    Edmund C Chang
    Department of Molecular and Integrative Physiology, University of Illinois, 524 Burrill Hall, 407 South Goodwin Avenue, Urbana, 61801 3704, USA
    Endocrinology 147:4831-42. 2006
    ..Our observations suggest that the relative levels of ERbeta and ERalpha in breast cancers are likely to impact cell proliferation and the activities of diverse signaling pathways and their response to ER ligands and endocrine therapies...
  97. ncbi Genomic actions of estrogen receptor alpha: what are the targets and how are they regulated?
    Willem Jan Welboren
    Department of Molecular Biology, Faculty of Science, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen, HB Nijmegen, The Netherlands
    Endocr Relat Cancer 16:1073-89. 2009
    The estrogen receptor alpha (ERalpha) is a ligand-dependent transcription factor that regulates a large number of genes in many different target tissues and is important in the development and progression of breast cancer...
  98. pmc Mechano-transduction in osteoblastic cells involves strain-regulated estrogen receptor alpha-mediated control of insulin-like growth factor (IGF) I receptor sensitivity to Ambient IGF, leading to phosphatidylinositol 3-kinase/AKT-dependent Wnt/LRP5 recept
    Andrew Sunters
    Department of Veterinary Basic Sciences, Royal Veterinary College, Royal College Street, London NW1 0TU, United Kingdom
    J Biol Chem 285:8743-58. 2010
    ..Strain-related IGF-IR activation of AKT requires estrogen receptor alpha (ERalpha) with which IGF-1R physically associates...
  99. pmc PI3-kinase in concert with Src promotes the S-phase entry of oestradiol-stimulated MCF-7 cells
    G Castoria
    Dipartimento di Patologia Generale, Facolta di Medicina e Chirurgia, II Universita di Napoli, Via L De Crecchio, 7, 80138 Napoli, Italy
    EMBO J 20:6050-9. 2001
    ..The ternary complex probably favours hormone activation of Src- and PI3-kinase-dependent pathways, which converge on cell cycle progression...
  100. pmc Ancestry-shift refinement mapping of the C6orf97-ESR1 breast cancer susceptibility locus
    Simon N Stacey
    deCODE Genetics, Reykjavik, Iceland
    PLoS Genet 6:e1001029. 2010
    ..The locus is on 6q25.1 in proximity to the C6orf97 and estrogen receptor alpha (ESR1) genes...
  101. pmc Estrogen receptor-alpha expression in the mammary epithelium is required for ductal and alveolar morphogenesis in mice
    Yuxin Feng
    Department of Cell and Cancer Biology, Vontz Center for Molecular Studies, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    Proc Natl Acad Sci U S A 104:14718-23. 2007
    ..These observations suggest that ERalpha expression in the mammary epithelium is essential for normal ductal morphogenesis during puberty and alveologenesis during pregnancy and lactation...

Research Grants71

  1. DNA methylation in aging, race and prostate cancer
    Rajvir Dahiya; Fiscal Year: 2006
    ..This information can be used for better management of prostate cancer using DNA methylated genes as diagnostic or prognostic biomarkers. ..
  2. Physiology of Hypothalamic Neurosteroidal Progesterone
    Paul E Micevych; Fiscal Year: 2013
    ..This type of infertility exhibits excess estrogen production without ovulation that can lead to polycystic ovary syndrome, irregular vaginal bleeding, metabolic abnormalities as well as endometrial polyps, hyperplasia, and even cancer. ..
  3. Vitamin D and Estrogen Action in Bone: Concerted Role for hnRNPs in the C Family
    John S Adams; Fiscal Year: 2013
    ....
  4. Gonadal Steroid Receptors and the Hypothalamo-Pituitary-Adrenal Axis
    Robert J Handa; Fiscal Year: 2013
    ....
  5. Mechanism of Age-Related Change in Estrogen Receptor Beta Expression in Rat Brain
    JENNE MITCHELL WESTBERRY; Fiscal Year: 2012
    ..Furthermore, we will develop a new methodology that will be critical for examining epigenetic changes in gene expression in a temporal and spatial manner in neural tissue with heterogeneous cell populations. ..
  6. Role of Estrogen Receptors in Lupus-Modulators of the Inflammatory Response
    Gary S Gilkeson; Fiscal Year: 2013
    ..Estrogen acts primarily via its receptors, estrogen receptor alpha and beta (ER[unreadable]/ER[unreadable])...
  7. Gender-Specific Role of p202 in Lupus Susceptibility
    Divaker Choubey; Fiscal Year: 2010
    ..Our studies will increase the understanding of the molecular basis of sex bias in lupus disease and could potentially lead to better diagnostic tools as well as disease monitoring, and effective treatments. 1 ..
  8. Crosstalk between estrogen and bile acid signaling pathway
    Ruitang Deng; Fiscal Year: 2013
    ..Understanding the mechanisms and pathological consequences will provide a molecular basis to develop new drugs to treat or prevent those diseases. ..
  9. Novel Mechanisms Regulating the Adipocyte-Brain Hepatocyte Axis
    Philipp E Scherer; Fiscal Year: 2013
    ..Combined, we feel we are uniquely positioned to address these questions that tie at the core of homeostatic control of energy homeostasis. ..
  10. Estrogen signaling in portopulmonary hypertension
    Steven M Kawut; Fiscal Year: 2013
    ..We showed that variation in genes linked to estrogen signaling (aromatase and estrogen receptor alpha (ESR1)) and higher estradiol levels significantly increased the risk of PPHTN in patients with advanced ..
  11. CELLULAR MECHANISMS IN THE INDUCTION OF AROMATASE
    Carole R Mendelson; Fiscal Year: 2013
    ..We anticipate that our studies will shed new light on the etiology of this devastating disease. ..
  12. Effects of Bisphenol A Exposure on Genomic Imprinting in the Mouse
    Martha Susiarjo; Fiscal Year: 2012
    ..question of whether estrogen receptors mediate BPA-induced effects, mice lacking functional genes for the estrogen receptor alpha and beta will be exposed to BPA and the effects on epigenetic gene regulation will be assessed...
  13. Regulation of miRNA in breast cancer
    Carolyn M Klinge; Fiscal Year: 2013
    ..SERM) tamoxifen (TAM) is the most widely used endocrine therapy for the treatment and prevention of estrogen receptor alpha (ER1) positive breast cancer...
  14. Regulation of dendritic cells by estrogen receptors during influenza infection
    Susan Kovats; Fiscal Year: 2012
    ..This project will determine how one such physiological factor, estrogen receptor alpha (ER1) signaling, regulates the innate immune response to influenza virus infection in mice...
  15. Effect of Insulin on Estrogen Receptor Alpha Activity in Human Endometrial Cells
    CLARE ANN FLANNERY; Fiscal Year: 2013
    ..Also, the treatment paradigm for women with T2DM may change to limit exposure to high doses of therapeutic insulin. ..
  16. Effects of fetal bisphenol A exposure on mouse epigenome
    Martha Susiarjo; Fiscal Year: 2013
    ..The candidate will include mice lacking the functional genes for estrogen receptor alpha and beta as BPA is an estrogen and the project aims to investigate if these receptors mediate BPA effects ..
  17. Biological Mechanisms of Arterial Stiffening With Age and Estrogen Deficiency
    KERRIE MOREAU; Fiscal Year: 2010
    ..g., NADPH) and antioxidant (e.g., glutathione peroxidase) enzymes, vasoconstrictors (endothelin- 1), and estrogen receptor alpha (ERalpha)...
  18. Regulation of miRNA expression in breast cancer cells
    CAROLYN KLINGE; Fiscal Year: 2009
    ..SERM) tamoxifen (TAM) is the most widely used endocrine therapy for the treatment and prevention of estrogen receptor alpha (ERalpha) positive breast cancer...
  19. Fliz1 regulation of GATA-3 in breast cancer
    Janice E Knepper; Fiscal Year: 2013
    ..breast epithelium and in estrogen receptor positive tumors, as GATA-3 directly regulates expression of estrogen receptor alpha (ER?)...
  20. Estrogen signaling transgenic mouse models
    Richard R Behringer; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Estrogen receptor alpha (ERa) and beta (ER[unreadable]) are members of the nuclear receptor superfamily and mediate the actions of estrogens...
  21. ERalpha and the metabolic syndrome
    Andrea L Hevener; Fiscal Year: 2013
    ....
  22. Rat Models for Sex Steroid Action
    Michael J Soares; Fiscal Year: 2013
    ..Estradiol binds and signals through estrogen receptor alpha (ESR1) and estrogen receptor beta (ESR2), while progesterone signals through the progesterone receptor (..
  23. Short-term estradiol use in middle-age: implications for female cognitive aging
    Jill M Daniel; Fiscal Year: 2013
    ..The central hypothesis to be tested is that lasting changes in levels of estrogen receptor alpha (ER[unreadable]) and in the insulin-like growth factor-1 (IGF-1) system in the hippocampus resulting from ..
  24. Nuclear cofactors in hormone signaling
    Hongwu Chen; Fiscal Year: 2012
    ..Understanding the process will provide novel insights to the underlying molecular mechanisms of steroid receptor function in female reproduction and breast cancers as well as other endocrine disorders. ..
  25. Perinatal exposure to environmental estrogens and asthma pathogenesis
    Terumi Midoro Horiuti; Fiscal Year: 2010
    ..potentiate the synthesis and release of allergic mediators from mast cells, through a membrane form of estrogen receptor alpha. Further, ovarectomized BALB/c mice that fail to make an IgE response after typical allergic ..
  26. Development of Estrogen Receptor B Selective Receptor Agonists to Treat Neuropath
    ETHAN SAMUEL BURSTEIN; Fiscal Year: 2012
    ..their high selectivity for ER[unreadable], they do not produce the feminizing side effects attributed to estrogen receptor alpha (ERa) activation and display many desirable attributes for a drug candidate: no apparent cardiovascular ..
  27. ESTROGEN AND COGNITION OVER THE LIFESPAN
    Thomas C Foster; Fiscal Year: 2010
    ..The results of our experiments may provide the groundwork for future development of ER gene therapies to slow or prevent cognitive decline associated with aging and age- related diseases. ..
  28. Nuclear Architecture, NcRNAs and Epigenetics in Transcriptional Regulation by ER
    Chunru Lin; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Estradiol, which acts through the Estrogen Receptor alpha (ER[unreadable]), is essential for the development and homeostasis of female reproductive function, exerting critical control of many ..
  29. Prevalence of CD24 epigenetic silencing in breast tumors and ERalpha status
    Benny Abraham Kaipparettu; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): 1. Abstract Two-thirds of breast cancers express estrogen receptor alpha (ER1) and rely upon ER1 signaling for their growth...
  30. Epigenetic Regulation of Breast Cancer Progression by the Proto-oncogene PELP1
    MONICA MANN; Fiscal Year: 2013
    ..Estrogen and its target estrogen receptor alpha (ER[unreadable]), a master transcriptional regulator, are implicated in the initiation and progression of ..
  31. Hypoxia and Aberrant Uterine Vascular Adaptation in Pregnancy
    Lubo Zhang; Fiscal Year: 2013
    ....
  32. A Neoadjuvant Trial of Anastrazole and A Novel SRC Inhibitor, AZD0530, for LABC
    JOYCE MARIE contact SLINGERLAND; Fiscal Year: 2010
    ..This trial may form the basis for subsequent, larger clinical trials to enhance the efficacy of endocrine therapy for breast cancer. ..
  33. Molecular Analysis of Uterine Receptivity
    FRANCESCO JOHN DEMAYO; Fiscal Year: 2013
    ..We have preliminary data illustrating that ablation of Ihh results in an increase in the expression of Estrogen Receptor alpha (ER1) and estrogen (E2) regulated genes in the endometrial epithelium...
  34. Estrogen and Memory: Genetic Variation and Neuroimaging
    Susan K Conroy; Fiscal Year: 2013
    ..We will also investigate how changes in estrogen as a result of breast cancer treatment alter brain function, and relate these changes to memory function. ..
  35. Hepatic Estrogen Signaling and Protection Against Insulin Resistance
    MELISSA NICOLE MARTINEZ; Fiscal Year: 2013
    ..Our overarching hypothesis is that hepatic estrogen signaling mediated by estrogen receptor alpha (ER1) promotes insulin sensitivity by bypassing the signaling defect to FoxO1 created by high-fat feeding...
  36. Regulation of GPER-mediated Signaling in the Vasculature by Calmodulin
    Kim Tran; Fiscal Year: 2012
    ..It is expected that the proposed studies will provide timely information that help form the basis for targeting estrogen receptor subtypes for preventive and therapeutic purposes. ..
  37. Estrogen regulation of inflammatory mediator signaling
    William P Clarke; Fiscal Year: 2011
    ..This work will provide a basis for understanding the enhanced sensitivity of women to pain and provide new targets for improved pain pharmacotherapy. ..
  38. Nuclear Architecture, NcRNAs and Epigenetics in Transcriptional Regulation by ER
    Chunru Lin; Fiscal Year: 2013
    Project Summary Estradiol, which acts through the Estrogen Receptor alpha (ER[unreadable]), is essential for the development and homeostasis of female reproductive function, exerting critical control of many transcriptional programs, ..
  39. Chemoprevention of pituitary gonadotrope tumors
    T Rajendra Kumar; Fiscal Year: 2013
    ..The proposed research is significant because it is expected to vertically advance and expand understanding of how chemopreventive agents targeted to block estrogen and hedgehog signaling regulate gonadotrope/null cell adenomas. ..
  40. Molecular regulation of breast cancer growth
    Marsha A Moses; Fiscal Year: 2010
    ..In addition, the expression of the estrogen receptor alpha (ERalpha) was significantly downregulated by NGAL over-expression...
  41. Translational Insights into Estrogen Receptor alpha-Positive Luminal Breast Cance
    ROBERT DAVID SCHREIBER; Fiscal Year: 2013
    ..novel combinatorial tumor-targeted therapies to effectively treat mice bearing naturally arising and transplanted mouse ER?+ (luminal) mammary cancers with the hope of translating our findings into new treatments for human breast cancer ..
  42. Estrogen signaling transgenic mouse models
    Richard R Behringer; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Estrogen receptor alpha (ERa) and beta (ER[unreadable]) are members of the nuclear receptor superfamily and mediate the actions of estrogens...
  43. ERalpha Regulation of Intestinal Homeostasis & Tumorigenesis
    Karen A Gould; Fiscal Year: 2010
    ....
  44. Ligand-independent signaling of estrogen receptor beta and the aging brain
    Toni R Pak; Fiscal Year: 2013
    ..The expected results will further our understanding of ER2 signaling in the post-menopausal brain by elucidating the precise molecular mechanisms that drive estrogen-independent regulation of ER2 target genes. ..
  45. Screening of FoxA1-ER-DNA disruptors for development of breast cancer therapeutic
    Christopher L Warren; Fiscal Year: 2011
    ..PUBLIC HEALTH RELEVANCE: Estrogen receptor alpha (ERa) is the major therapeutic target for breast cancer, and ERa binding at target genes in breast cancer ..
  46. Prolactin: mammary progenitors and tumor initiating cells in luminal carcinomas
    Linda A Schuler; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): 75% of all breast tumors in women express estrogen receptor alpha (ER?+)...
  47. NcoA5, a unique nuclear receptor coactivator in hepatocarcinogenesis
    Hua Xiao; Fiscal Year: 2012
    ..This will not only advance our understanding of the etiological mechanisms of HCC, but also provide the fields of basic and preclinical studies with a new mouse model that mimics the initiation and progression of human HCC. ..
  48. Therapeutic implication of estrogen receptor-p53 interaction in mitochondria
    Keshav K Singh; Fiscal Year: 2013
    ....
  49. Novel estrogen receptor ligands from plant genomics
    John M Littleton; Fiscal Year: 2012
    ..This technology promises to change this by applying genomics approaches to plant drug discovery in this area. ..
  50. ESTROGEN MODULATION OF HUMAN NOCICEPTORS
    Kenneth M Hargreaves; Fiscal Year: 2012
    ..with either BK/PGE2 or with capsaicin Specific Aim 3: Determine whether specific polymorphisms of the estrogen receptor alpha (ER1) or beta (ER2) are associated with increased BK/PGE2- or capsaicin-evoked release of SP from ..
  51. Mannosidase inhibitors as therapeutics for glycoprotein misfolding diseases
    Kelley W Moremen; Fiscal Year: 2010
    ....
  52. Dissecting Estrogen Control of Sexual Differentiation of the Brain
    Jessica Tollkuhn; Fiscal Year: 2010
    ..Through chromatin immunoprecipitation analysis (ChIP), I will demonstrate the direct recruitment of estrogen receptor alpha (ERa) to the AR locus in the neonatal BNST of males...
  53. Roles of Novel Protein Complexes in Estrogen and Progesterone Receptor Signaling
    Zafar Nawaz; Fiscal Year: 2012
    ..Given these facts, the understanding of coactivator biology and their mechanism of action will be useful in developing new therapies. ..
  54. Development of Breast Cancer Risk Model Based on Estrogen Metabolomics
    Richard J Santen; Fiscal Year: 2013
    ..We propose an integrative hypothesis regarding the carcinogenic process which involves both estrogen receptor alpha (ER[unreadable]) dependent as well as ER[unreadable] independent actions...
  55. Estrogen regulation of channels involved in the control of energy homeostasis
    TROY ADAM ROEPKE; Fiscal Year: 2010
    ..Finally, the independent phase will address the potential mechanisms that environmental estrogens can impact hypothalamic functions. ..
  56. Comparative Genomics Study of Foxa/ER Targets in Liver Cancer and Breast Cancer
    Zhaoyu Li; Fiscal Year: 2012
    ..In vitro studies show that estrogen signaling through estrogen receptor alpha (ER[unreadable]) in promoting the growth of breast cancer cells relies on forkhead box protein A (Foxa)...
  57. Effects of Estradiol &Phytoestrogens on Stress Responsivity
    Pauline M Maki; Fiscal Year: 2013
    ..Positive findings would provide a rationale for subsequent investigations of ER-beta agonists in the treatment of anxiety symptoms and disorders in women. ..
  58. Epigenetic Molecular Mechanisms and Reproductive Transitions
    Deena M Walker; Fiscal Year: 2011
    ..The focus will be the estrogen receptor alpha (ERa) and kisspeptin, chosen because these hypothalamic genes are expressed in a sexually dimorphic ..
  59. Validation of the Estrogen Related Receptor as a therapeutic target in cancer
    Donald P McDonnell; Fiscal Year: 2012
    ..In this study we propose to use both cellular and animal models to assess the cause and effect relationship between ERRalpha activity and the pathophysiology of both ERalpha-positive and ERalpha-negative tumors. ..
  60. Comparative Genomics Study of Foxa/ER Targets in Liver Cancer and Breast Cancer
    Zhaoyu Li; Fiscal Year: 2013
    ..In vitro studies show that estrogen signaling through estrogen receptor alpha (ER[unreadable]) in promoting the growth of breast cancer cells relies on forkhead box protein A (Foxa)...
  61. G protein-coupled estrogen receptor GPER and breast carcinogenesis
    Eric R Prossnitz; Fiscal Year: 2013
    ..Further development of this antagonist could lead to a new drug for the treatment of GPER-expressing breast tumors. ..
  62. Investigation of ER alpha expression on male behavior under field conditions
    Brian Keane; Fiscal Year: 2013
    ..Data from laboratory studies demonstrate that estrogen, acting via estrogen receptor alpha (ER?), influences many aspects of sociosexual behavior in male mammals including affiliation, aggression, ..
  63. Do estrogen receptors in B cells and DC mediate sex bias in murine lupus?
    Susan Kovats; Fiscal Year: 2009
    ..This knowledge will help to understand why autoimmune diseases preferentially afflict women. ..
  64. Transgenic Models of Estrogen Receptor Activity in Bone
    Joseph Alexander; Fiscal Year: 2004
    ..abstract_text> ..
  65. ER beta selective agonist coronary protection-menopause
    R Hermsmeyer; Fiscal Year: 2005
    ..The new ERbetaA is to be contrasted with PremPro(r) (oral conjugated equine estrogens plus medroxyprogesterone acetate) which failed to provide cardiovascular protection in the Women's Health Initiative. ..
  66. SYMPATHETIC NERVE REMODELING IN THE ADULT UTERUS
    Peter Smith; Fiscal Year: 2003
    ..estrus, 2) estrogen administration decreases sympathetic nerve density, and 3) mice lacking a functional estrogen receptor alpha have uteri that are grossly hyperinnervated...
  67. CHEMOPREVENTION OF MAMMARY TUMORS BY TAMOXIFEN AND SOY
    Andreas Constantinou; Fiscal Year: 2002
    ..2) Identify the mechanism of the anticipated additive/synergistic chemopreventive effect between tamoxifen and the active soy component. ..
  68. Mechanisms Regulating Reversal of Malignancy
    Priscilla Furth; Fiscal Year: 2009
    ..2. c. Test if pharmacological RXRalpha and/or PPARgamma agonists alone or in combination prevent development of ERalpha ductal hyperplasia and DCIS. ..
  69. Interferon and Raloxifene Effects on Cancer Cells
    CHERYL ROSENFELD; Fiscal Year: 2007
    ..The University is in the process of developing a Comparative Oncology Program. The campus provides a rich mix of disciplines and a collaborative environment, in which Dr. Rosenfeld is expected to continue to thrive. ..
  70. Estrogen Receptors and Maintenance of Lens Transparency
    Vicki Davis; Fiscal Year: 2005
    ..This study will provide the gateway for future studies to investigate how exposure to various estrogens influence risk of age-related cataracts and the potential of estrogens as a therapy for cataract prevention. ..
  71. MOLECULAR ASSAY FOR ESTROGEN RECEPTORS IN BREAST TUMORS
    Indira Poola; Fiscal Year: 2002
    ..Such outcomes will be significant for the breast cancer patients who are resistant or acquire resistance to anti-estrogen therapies. ..