estrogen receptors

Summary

Summary: Cytoplasmic proteins that bind estrogens and migrate to the nucleus where they regulate DNA transcription. Evaluation of the state of estrogen receptors in breast cancer patients has become clinically important.

Top Publications

  1. ncbi A multigene assay to predict recurrence of tamoxifen-treated, node-negative breast cancer
    Soonmyung Paik
    Division of Pathology, Operation Center, and the Biostatistics Center, National Surgical Adjuvant Breast and Bowel Project, Pittsburgh 15212, USA
    N Engl J Med 351:2817-26. 2004
  2. ncbi Race, breast cancer subtypes, and survival in the Carolina Breast Cancer Study
    Lisa A Carey
    Division of Hematology Oncology, School of Public Health, Department of Epidemiology, University of North Carolina Lineberger Comprehensive Cancer Center, Chapel Hill, NC 27599 7305, USA
    JAMA 295:2492-502. 2006
  3. ncbi Response to neoadjuvant therapy and long-term survival in patients with triple-negative breast cancer
    Cornelia Liedtke
    Department of Breast Medical Oncology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030 1439, USA
    J Clin Oncol 26:1275-81. 2008
  4. ncbi Prognostic and predictive factors in breast cancer by immunohistochemical analysis
    D C Allred
    Department of Pathology, University of Texas Health Science Center, San Antonio 78284, USA
    Mod Pathol 11:155-68. 1998
  5. ncbi Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors alpha and beta
    G G Kuiper
    Center for Biotechnology, Karolinska Institute, Huddinge, Sweden
    Endocrinology 138:863-70. 1997
  6. ncbi Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor beta
    G G Kuiper
    Center for Biotechnology and Department of Medical Nutrition, Karolinska Institute, Huddinge, Sweden
    Endocrinology 139:4252-63. 1998
  7. ncbi Gene-expression profiles to predict distant metastasis of lymph-node-negative primary breast cancer
    Yixin Wang
    Veridex LLC, a Johnson and Johnson Company, San Diego, CA, USA
    Lancet 365:671-9. 2005
  8. ncbi Immunohistochemical and clinical characterization of the basal-like subtype of invasive breast carcinoma
    Torsten O Nielsen
    Genetic Pathology Evaluation Centre, University of British Columbia, Vancouver Hospital and British Columbia Cancer Agency, Vancouver, British Columbia, Canada
    Clin Cancer Res 10:5367-74. 2004
  9. ncbi A transmembrane intracellular estrogen receptor mediates rapid cell signaling
    Chetana M Revankar
    Department of Cell Biology and Physiology, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA
    Science 307:1625-30. 2005
  10. ncbi Estrogen carcinogenesis in breast cancer
    James D Yager
    Bloomberg School of Public Health, Department of Environmental Health Sciences, Johns Hopkins University, Baltimore, MD 21205, USA
    N Engl J Med 354:270-82. 2006

Detail Information

Publications361 found, 100 shown here

  1. ncbi A multigene assay to predict recurrence of tamoxifen-treated, node-negative breast cancer
    Soonmyung Paik
    Division of Pathology, Operation Center, and the Biostatistics Center, National Surgical Adjuvant Breast and Bowel Project, Pittsburgh 15212, USA
    N Engl J Med 351:2817-26. 2004
    ..The likelihood of distant recurrence in patients with breast cancer who have no involved lymph nodes and estrogen-receptor-positive tumors is poorly defined by clinical and histopathological measures...
  2. ncbi Race, breast cancer subtypes, and survival in the Carolina Breast Cancer Study
    Lisa A Carey
    Division of Hematology Oncology, School of Public Health, Department of Epidemiology, University of North Carolina Lineberger Comprehensive Cancer Center, Chapel Hill, NC 27599 7305, USA
    JAMA 295:2492-502. 2006
    ..Gene expression analysis has identified several breast cancer subtypes, including basal-like, human epidermal growth factor receptor-2 positive/estrogen receptor negative (HER2+/ER-), luminal A, and luminal B...
  3. ncbi Response to neoadjuvant therapy and long-term survival in patients with triple-negative breast cancer
    Cornelia Liedtke
    Department of Breast Medical Oncology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030 1439, USA
    J Clin Oncol 26:1275-81. 2008
    ..In this study, we compared response to neoadjuvant chemotherapy and survival between patients with TNBC and non-TNBC...
  4. ncbi Prognostic and predictive factors in breast cancer by immunohistochemical analysis
    D C Allred
    Department of Pathology, University of Texas Health Science Center, San Antonio 78284, USA
    Mod Pathol 11:155-68. 1998
    ..In the future, these and other factors will be incorporated into a prognostic index that will better reflect the biologic diversity of breast cancer and that will more accurately predict clinical outcome...
  5. ncbi Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors alpha and beta
    G G Kuiper
    Center for Biotechnology, Karolinska Institute, Huddinge, Sweden
    Endocrinology 138:863-70. 1997
    ..The described differences between the ER subtypes in relative ligand binding affinity and tissue distribution could contribute to the selective action of ER agonists and antagonists in different tissues...
  6. ncbi Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor beta
    G G Kuiper
    Center for Biotechnology and Department of Medical Nutrition, Karolinska Institute, Huddinge, Sweden
    Endocrinology 139:4252-63. 1998
    ....
  7. ncbi Gene-expression profiles to predict distant metastasis of lymph-node-negative primary breast cancer
    Yixin Wang
    Veridex LLC, a Johnson and Johnson Company, San Diego, CA, USA
    Lancet 365:671-9. 2005
    ....
  8. ncbi Immunohistochemical and clinical characterization of the basal-like subtype of invasive breast carcinoma
    Torsten O Nielsen
    Genetic Pathology Evaluation Centre, University of British Columbia, Vancouver Hospital and British Columbia Cancer Agency, Vancouver, British Columbia, Canada
    Clin Cancer Res 10:5367-74. 2004
    ..Currently, there exist clinical assays that identify ER+/luminal and HER2-overexpressing tumors, and we sought to develop a clinical assay for breast basal-like tumors...
  9. ncbi A transmembrane intracellular estrogen receptor mediates rapid cell signaling
    Chetana M Revankar
    Department of Cell Biology and Physiology, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA
    Science 307:1625-30. 2005
    ..Although it is traditionally thought to control transcriptional activation through the classical nuclear estrogen receptors, it also initiates many rapid nongenomic signaling events...
  10. ncbi Estrogen carcinogenesis in breast cancer
    James D Yager
    Bloomberg School of Public Health, Department of Environmental Health Sciences, Johns Hopkins University, Baltimore, MD 21205, USA
    N Engl J Med 354:270-82. 2006
  11. ncbi Triple-negative breast cancer: clinical features and patterns of recurrence
    Rebecca Dent
    Department of Medical Oncology, Sunnybrook Health Sciences Center, University of Toronto, Ontario, Canada
    Clin Cancer Res 13:4429-34. 2007
    ..To compare the clinical features, natural history, and outcomes for women with "triple-negative" breast cancer with women with other types of breast cancer...
  12. pmc Estrogen receptors and human disease
    Bonnie J Deroo
    Receptor Biology Section, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, North Carolina 27709, USA
    J Clin Invest 116:561-70. 2006
    ..This Review will describe diseases in which estrogen, through the ER, plays a role in the development or severity of disease...
  13. ncbi Gene expression and benefit of chemotherapy in women with node-negative, estrogen receptor-positive breast cancer
    Soonmyung Paik
    Division of Pathology, Operations Center, and Biostatistical Center, National Surgical Adjuvant Breast and Bowel Project, Pittsburgh, PA 15212, USA
    J Clin Oncol 24:3726-34. 2006
    ..The relationship between the RS and chemotherapy benefit is not known...
  14. ncbi Gene expression profiling in breast cancer: understanding the molecular basis of histologic grade to improve prognosis
    Christos Sotiriou
    Functional Genomics and Translational Research Unit, Universite Libre de Bruxelles, Brussels, Belgium
    J Natl Cancer Inst 98:262-72. 2006
    ..We examined whether histologic grade was associated with gene expression profiles of breast cancers and whether such profiles could be used to improve histologic grading...
  15. pmc Meta-analysis of gene expression profiles in breast cancer: toward a unified understanding of breast cancer subtyping and prognosis signatures
    Pratyaksha Wirapati
    Swiss Institute of Bioinformatics, Batiment Genopode, University of Lausanne, 1015 Lausanne, Switzerland
    Breast Cancer Res 10:R65. 2008
    ....
  16. ncbi Molecular basis of agonism and antagonism in the oestrogen receptor
    A M Brzozowski
    Protein Structure Group, Chemistry Department, University of York, UK
    Nature 389:753-8. 1997
    ..In addition, each class of ligand induces a distinct conformation in the transactivation domain of the LBD, providing structural evidence of the mechanism of antagonism...
  17. ncbi Genome-wide analysis of estrogen receptor binding sites
    Jason S Carroll
    Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, 44 Binney St, Boston, Massachusetts 02115, USA
    Nat Genet 38:1289-97. 2006
    ..Furthermore, this resource has allowed the identification of cis-regulatory sites in previously unexplored regions of the genome and the cooperating transcription factors underlying estrogen signaling in breast cancer...
  18. ncbi Mechanisms of estrogen action
    S Nilsson
    KaroBio AB and Department of Biosciences, Karolinska Institute, Novum, Huddinge, Sweden
    Physiol Rev 81:1535-65. 2001
    ..Just as transgenic mice were produced in which estrogen receptors had been inactivated and we thought that we were about to understand the role of estrogen receptors in ..
  19. ncbi Estrogen receptors: how do they signal and what are their targets
    Nina Heldring
    Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden
    Physiol Rev 87:905-31. 2007
    ..In this review we focus on several of the interesting recent discoveries concerning estrogen receptors, on estrogen as a morphogen, and on the molecular mechanisms of anti-estrogen signaling.
  20. pmc Breast cancer classification and prognosis based on gene expression profiles from a population-based study
    Christos Sotiriou
    Division of Clinical Sciences, National Cancer Institute, Advanced Technology Center, 8717 Grovemont Circle, Gaithersburg, MD 20877, USA
    Proc Natl Acad Sci U S A 100:10393-8. 2003
    ..When taken together with other array studies, our results highlight the consistent biological and clinical associations with gene expression profiles...
  21. ncbi The structural basis of estrogen receptor/coactivator recognition and the antagonism of this interaction by tamoxifen
    A K Shiau
    Howard Hughes Medical Institute and the Department of Biochemistry and Biophysics, University of California at San Francisco, 94143 0448, USA
    Cell 95:927-37. 1998
    ..These structures reveal the two distinct mechanisms by which structural features of OHT promote this "autoinhibitory" helix 12 conformation...
  22. ncbi Mechanisms of estrogen receptor signaling: convergence of genomic and nongenomic actions on target genes
    Linda Björnström
    Department of Cell and Molecular Biology, Karolinska Institutet, SE 171 77 Stockholm, Sweden
    Mol Endocrinol 19:833-42. 2005
    b>Estrogen receptors (ERs) act by regulating transcriptional processes...
  23. ncbi Mechanisms of tamoxifen resistance: increased estrogen receptor-HER2/neu cross-talk in ER/HER2-positive breast cancer
    Jiang Shou
    The Breast Center, Baylor College of Medicine, Houston, TX 77030, USA
    J Natl Cancer Inst 96:926-35. 2004
    ..We used a breast cancer model system with high expression of AIB1 and HER2 to investigate the possible mechanisms underlying this resistance...
  24. ncbi Chromosome-wide mapping of estrogen receptor binding reveals long-range regulation requiring the forkhead protein FoxA1
    Jason S Carroll
    Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, 44 Binney Street, Boston, Massachusetts 02115, USA
    Cell 122:33-43. 2005
    ..Furthermore, knockdown of FoxA1 expression blocks the association of ER with chromatin and estrogen-induced gene expression demonstrating the necessity of FoxA1 in mediating an estrogen response in breast cancer cells...
  25. ncbi Mechanisms of tamoxifen-induced apoptosis
    S Mandlekar
    Department of Drug Metabolism and Pharmacokinetics, DuPont Pharmaceuticals Company, Newark, DE 19711, USA
    Apoptosis 6:469-77. 2001
    ..These various signaling pathways underlying TAM-induced apoptosis will be reviewed in this article...
  26. ncbi Recommendations from an international expert panel on the use of neoadjuvant (primary) systemic treatment of operable breast cancer: an update
    Manfred Kaufmann
    Department of Obstetrics and Gynecology, J W Goethe University Hospital, Frankfurt, Germany
    J Clin Oncol 24:1940-9. 2006
    ..As part of this effort, data published to date were reviewed critically and indications for neoadjuvant treatment were newly defined...
  27. ncbi Estrogen receptor null mice: what have we learned and where will they lead us?
    J F Couse
    Receptor Biology Section, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Endocr Rev 20:358-417. 1999
    ..abstract truncated]..
  28. ncbi Locoregional relapse and distant metastasis in conservatively managed triple negative early-stage breast cancer
    Bruce G Haffty
    Department of Radiation Oncology, Cancer Institute of New Jersey, Robert Wood Johnson Medical School University of Medicine and Dentistry of New Jersey, New Brunswick, NJ 08903 2681, USA
    J Clin Oncol 24:5652-7. 2006
    ..To determine the prognostic significance of triple negative breast cancers with respect to locoregional relapse and distant metastasis in conservatively managed breast cancer patients...
  29. ncbi The triple negative paradox: primary tumor chemosensitivity of breast cancer subtypes
    Lisa A Carey
    Division of Hematology Oncology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7305, USA
    Clin Cancer Res 13:2329-34. 2007
    ..Gene expression analysis identifies several breast cancer subtypes. We examined the relationship of neoadjuvant chemotherapy response to outcome among these breast cancer subtypes...
  30. ncbi Estrogen-induced activation of Erk-1 and Erk-2 requires the G protein-coupled receptor homolog, GPR30, and occurs via trans-activation of the epidermal growth factor receptor through release of HB-EGF
    E J Filardo
    Department of Medicine and Surgery, Rhode Island Hospital and Brown University, Providence 02903, USA
    Mol Endocrinol 14:1649-60. 2000
    ..Here, evidence is provided that estrogen-induced Erk-1/-2 activation occurs independently of known estrogen receptors, but requires the expression of the G protein-coupled receptor homolog, GPR30...
  31. ncbi Identity of an estrogen membrane receptor coupled to a G protein in human breast cancer cells
    P Thomas
    University of Texas Marine Science Institute, 750 Channel View Drive, Port Aransas, Texas 78373, USA
    Endocrinology 146:624-32. 2005
    ..actions initiated at the cell surface have been described in many tissues, the identities of the membrane estrogen receptors (mERs) mediating these actions remain unclear...
  32. pmc Cloning of a novel receptor expressed in rat prostate and ovary
    G G Kuiper
    Center for Biotechnology and Department of Medical Nutrition, Karolinska Institute, Huddinge, Sweden
    Proc Natl Acad Sci U S A 93:5925-30. 1996
    ..We conclude that clone 29 cDNA encodes a novel rat ER, which we suggest be named rat ERbeta to distinguish it from the previously cloned ER (ERalpha) from rat uterus...
  33. ncbi Effect of single and compound knockouts of estrogen receptors alpha (ERalpha) and beta (ERbeta) on mouse reproductive phenotypes
    S Dupont
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, College de France, BP 163, France
    Development 127:4277-91. 2000
    The functions of estrogen receptors (ERs) in mouse ovary and genital tracts were investigated by generating null mutants for ERalpha (ERalphaKO), ERbeta (ERbetaKO) and both ERs (ERalphabetaKO)...
  34. ncbi Common variants on chromosomes 2q35 and 16q12 confer susceptibility to estrogen receptor-positive breast cancer
    Simon N Stacey
    deCODE Genetics, Sturlugata 8, 101 Reykjavik, Iceland
    Nat Genet 39:865-9. 2007
    ..rs3803662 is near the 5' end of TNRC9 , a high mobility group chromatin-associated protein whose expression is implicated in breast cancer metastasis to bone...
  35. ncbi Dual inhibition of mTOR and estrogen receptor signaling in vitro induces cell death in models of breast cancer
    Anne Boulay
    Novartis Institutes for BioMedical Research Basel, Oncology Research, Novartis Pharma AG, Basel, Switzerland
    Clin Cancer Res 11:5319-28. 2005
    ..The role of the mTOR pathway in estrogen-driven proliferation and effects of combining RAD001 and letrozole were examined in vitro in two breast cancer models...
  36. ncbi Phosphatidylinositol 3-kinase/AKT-mediated activation of estrogen receptor alpha: a new model for anti-estrogen resistance
    R A Campbell
    Department of Surgery, Indiana University School of Medicine, Indianapolis 46202, USA
    J Biol Chem 276:9817-24. 2001
    b>Estrogen receptors (ERs) mediate most of the biological effects of estrogen in mammary and uterine epithelial cells by binding to estrogen response elements in the promoter region of target genes or through protein-protein interactions...
  37. ncbi Estrogen signaling through the transmembrane G protein-coupled receptor GPR30
    Eric R Prossnitz
    Department of Cell Biology and Physiology, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA
    Annu Rev Physiol 70:165-90. 2008
    ..In this review, we provide an overview of the evidence for the cellular and physiological actions of GPR30 in estrogen-dependent processes and discuss the relationship of GPR30 with classical estrogen receptors.
  38. ncbi American Society of Clinical Oncology 2007 update of recommendations for the use of tumor markers in breast cancer
    Lyndsay Harris
    Yale Cancer Center, Yale University, New Haven, CT, USA
    J Clin Oncol 25:5287-312. 2007
    ..To update the recommendations for the use of tumor marker tests in the prevention, screening, treatment, and surveillance of breast cancer...
  39. pmc Interaction of oestrogen receptor with the regulatory subunit of phosphatidylinositol-3-OH kinase
    T Simoncini
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 407:538-41. 2000
    ..Our findings define a physiologically important non-nuclear oestrogen-signalling pathway involving the direct interaction of ER alpha with PI(3)K...
  40. ncbi Intratumoral estrogens and estrogen receptors in human non-small cell lung carcinoma
    Hiromichi Niikawa
    Department of Pathology, Tohoku University School of Medicine, Japan
    Clin Cancer Res 14:4417-26. 2008
    ..Therefore, we examined intratumoral estradiol concentrations in NSCLC to examine local actions of estrogens in NSCLC...
  41. ncbi Descriptive analysis of estrogen receptor (ER)-negative, progesterone receptor (PR)-negative, and HER2-negative invasive breast cancer, the so-called triple-negative phenotype: a population-based study from the California cancer Registry
    Katrina R Bauer
    Public Health Institute California Cancer Registry, Sacramento, California 95815 4402, USA
    Cancer 109:1721-8. 2007
    ..The triple-negative phenotype is important because of its relation to the basal-like subtype of breast cancer...
  42. ncbi Tamoxifen-induced rapid death of MCF-7 breast cancer cells is mediated via extracellularly signal-regulated kinase signaling and can be abrogated by estrogen
    Aiping Zheng
    Institute of Biomedicine, Department of Anatomy, University of Turku, Tykistokatu 6A, 20520 Turku, Finland
    Endocrinology 148:2764-77. 2007
    ..the rapid effects of Tam in MCF-7 and T47D cells but not in MDA-MB-231 cells, which implies a role for estrogen receptors in the protective effect of estrogen...
  43. ncbi Race and triple negative threats to breast cancer survival: a population-based study in Atlanta, GA
    Mary Jo Lund
    Department of Epidemiology, Rollins School of Public Health, Emory University, 1518 Clifton Road, NE, Atlanta, GA 30322, USA
    Breast Cancer Res Treat 113:357-70. 2009
    ..This study examines association of the ER/PR/HER2 subtypes with race and breast cancer survival...
  44. ncbi Breast cancer subtype approximated by estrogen receptor, progesterone receptor, and HER-2 is associated with local and distant recurrence after breast-conserving therapy
    Paul L Nguyen
    Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA, USA
    J Clin Oncol 26:2373-8. 2008
    ..To determine whether breast cancer subtype is associated with outcome after breast-conserving therapy (BCT) consisting of lumpectomy and radiation therapy...
  45. pmc Regulation of ERBB2 by oestrogen receptor-PAX2 determines response to tamoxifen
    Antoni Hurtado
    Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
    Nature 456:663-6. 2008
    ..These data provide mechanistic insight into the molecular basis of endocrine resistance in breast cancer...
  46. ncbi Transcriptional regulation of the estrogen-inducible pS2 breast cancer marker gene by the ERR family of orphan nuclear receptors
    D Lu
    Molecular Oncology Group, McGill University Health Centre, , , H3A 1A1 Canada
    Cancer Res 61:6755-61. 2001
    ..ERRs) alpha, beta, and gamma are orphan nuclear hormone receptors that share significant homology with the estrogen receptors (ERs) but are not activated by natural estrogens...
  47. ncbi Prognostic value of Ki67 expression after short-term presurgical endocrine therapy for primary breast cancer
    Mitch Dowsett
    Academic Department of Biochemistry, 4th Floor, Wallace Wing, The Royal Marsden Hospital, Fulham Road, London SW3 6 JJ, UK
    J Natl Cancer Inst 99:167-70. 2007
    ....
  48. ncbi Molecular determinants for the tissue specificity of SERMs
    Yongfeng Shang
    Department of Adult Oncology, Dana Farber Cancer Institute, 44 Binney Street, and Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Science 295:2465-8. 2002
    ..Thus cell type- and promoter-specific differences in coregulator recruitment determine the cellular response to SERMs...
  49. pmc Generation and reproductive phenotypes of mice lacking estrogen receptor beta
    J H Krege
    Department of Pathology, University of North Carolina, Chapel Hill, NC 27599 7525, USA
    Proc Natl Acad Sci U S A 95:15677-82. 1998
    ..Two estrogen receptors (ERs) have been identified to date, ERalpha and ERbeta...
  50. ncbi Rapid actions of plasma membrane estrogen receptors
    M J Kelly
    Dept of Physiology and Pharmacology, School of Medicine, Oregon Health Sciences University, Portland, OR 97201, USA
    Trends Endocrinol Metab 12:152-6. 2001
    Functional evidence for the existence of plasma membrane estrogen receptors in a variety of cell types continues to accumulate...
  51. ncbi Estrogenic and antiestrogenic properties of resveratrol in mammary tumor models
    K P Bhat
    Program for Collaborative Research in the Pharmaceutical Sciences, Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    Cancer Res 61:7456-63. 2001
    ..In rodent models, carcinogen-induced preneoplastic lesions and mammary tumors are inhibited. These data suggest that resveratrol may have beneficial effects if used as a chemopreventive agent for breast cancer...
  52. ncbi International Union of Pharmacology. LXIV. Estrogen receptors
    Karin Dahlman-Wright
    Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden
    Pharmacol Rev 58:773-81. 2006
  53. ncbi Binding and activation of the seven-transmembrane estrogen receptor GPR30 by environmental estrogens: a potential novel mechanism of endocrine disruption
    Peter Thomas
    Marine Science Institute, University of Texas at Austin, 750 Channel View Drive, Port Aransas, TX 78373, USA
    J Steroid Biochem Mol Biol 102:175-9. 2006
    ..have been shown to exert estrogenic actions in wildlife and laboratory animals through binding to nuclear estrogen receptors (ERs) and subsequent transcription of estrogen responsive genes...
  54. pmc Gene expression profiling and histopathological characterization of triple-negative/basal-like breast carcinomas
    Bas Kreike
    Division of Radiation Oncology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    Breast Cancer Res 9:R65. 2007
    ..We examined the histopathological and gene-expression profile of triple-negative tumors to define subgroups with specific characteristics, including risk of developing distant metastases...
  55. ncbi Trastuzumab plus anastrozole versus anastrozole alone for the treatment of postmenopausal women with human epidermal growth factor receptor 2-positive, hormone receptor-positive metastatic breast cancer: results from the randomized phase III TAnDEM study
    Bella Kaufman
    Chaim Sheba Medical Center, Tel Hashomer, Israel
    J Clin Oncol 27:5529-37. 2009
    ..TAnDEM is the first randomized phase III study to combine a hormonal agent and trastuzumab without chemotherapy as treatment for human epidermal growth factor receptor 2 (HER2)/hormone receptor-copositive metastatic breast cancer (MBC)...
  56. ncbi Tamoxifen resistance in breast tumors is driven by growth factor receptor signaling with repression of classic estrogen receptor genomic function
    Suleiman Massarweh
    Department of Internal Medicine, Markey Cancer Center, University of Kentucky, Lexington, Kentucky, USA
    Cancer Res 68:826-33. 2008
    ..This study provides a rationale to combine HER inhibitors with tamoxifen in clinical studies, even in tumors that do not initially overexpress EGFR/HER2...
  57. pmc Alteration of reproductive function but not prenatal sexual development after insertional disruption of the mouse estrogen receptor gene
    D B Lubahn
    Department of Pathology, University of North Carolina, Chapel Hill 27599
    Proc Natl Acad Sci U S A 90:11162-6. 1993
    ..Prenatal male and female reproductive tract development can therefore occur in the absence of estradiol receptor-mediated responsiveness...
  58. ncbi Estrogen receptor pathways to AP-1
    P J Kushner
    Metabolic Research Unit, 1119 HSW, University of California, 3rd and Parnassus, 94143 0540, San Francisco, CA, USA
    J Steroid Biochem Mol Biol 74:311-7. 2000
    ..Finally, we consider the possible physiological significance of ER action at AP-1 sites...
  59. ncbi Definition of clinically distinct molecular subtypes in estrogen receptor-positive breast carcinomas through genomic grade
    Sherene Loi
    Jules Bordet Institute Machine Learning Group, Universite Libre de Bruxelles, Brussels, Belgium
    J Clin Oncol 25:1239-46. 2007
    ..However, although the basal and the ErbB2 subtypes are repeatedly recognized, identification of estrogen receptor (ER) -positive subtypes has been inconsistent. Therefore, refinement of their molecular definition is needed...
  60. ncbi Etiology of hormone receptor-defined breast cancer: a systematic review of the literature
    Michelle D Althuis
    Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Room 7084, 6120 Executive Boulevard, Rockville, MD 20852, USA
    Cancer Epidemiol Biomarkers Prev 13:1558-68. 2004
    ..Large population-based studies of determinants of hormone receptor-defined breast cancers defined using state-of-the-art quantitative immunostaining methods are needed to clarify the role of ER/PR expression in breast cancer etiology...
  61. ncbi Genome-wide orchestration of cardiac functions by the orphan nuclear receptors ERRalpha and gamma
    Catherine R Dufour
    Molecular Oncology Group, McGill University Health Centre, Montreal, Quebec H3A 1A1, Canada
    Cell Metab 5:345-56. 2007
    ..Our study thus reveals that the ERRs orchestrate a comprehensive cardiac transcriptional program and further suggests that modulation of ERR activities could be used to manage cardiomyopathies...
  62. pmc PGC-1alpha coactivates PDK4 gene expression via the orphan nuclear receptor ERRalpha: a mechanism for transcriptional control of muscle glucose metabolism
    Adam R Wende
    Center for Cardiovascular Research, Washington University School of Medicine, St Louis, MO 63110, USA
    Mol Cell Biol 25:10684-94. 2005
    ....
  63. pmc The estrogen-related receptor alpha (ERRalpha) functions in PPARgamma coactivator 1alpha (PGC-1alpha)-induced mitochondrial biogenesis
    Sylvia N Schreiber
    Biozentrum, University of Basel, CH 4056 Basel, Switzerland
    Proc Natl Acad Sci U S A 101:6472-7. 2004
    ..Thus, changes in ERRalpha activity could be linked to pathological changes in metabolic disease, such as diabetes...
  64. ncbi Preoperative chemotherapy in primary operable breast cancer: results from the European Organization for Research and Treatment of Cancer trial 10902
    J A van der Hage
    European Organization for Research and Treatment of Cancer Data Center, Brussels, Belgium
    J Clin Oncol 19:4224-37. 2001
    ....
  65. ncbi Caveolin proteins are essential for distinct effects of membrane estrogen receptors in neurons
    Marissa I Boulware
    Department of Neuroscience, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Neurosci 27:9941-50. 2007
    ..Many of these novel signaling processes are dependent on estrogen receptors (ERs) localized to the neuronal membrane...
  66. ncbi HER2 and response to paclitaxel in node-positive breast cancer
    Daniel F Hayes
    Breast Oncology Program, University of Michigan Comprehensive Cancer Center, Ann Arbor 48109, USA
    N Engl J Med 357:1496-506. 2007
    ..We hypothesized that HER2 positivity predicts a benefit from adjuvant doxorubicin doses above standard levels, from the addition of paclitaxel after adjuvant chemotherapy with doxorubicin plus cyclophosphamide, or from both...
  67. pmc Supervised risk predictor of breast cancer based on intrinsic subtypes
    Joel S Parker
    Lineberger Comprehensive Cancer Center, Carolina Center for Genome Sciences, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    J Clin Oncol 27:1160-7. 2009
    ..Test sets from 761 patients (no systemic therapy) were evaluated for prognosis, and 133 patients were evaluated for prediction of pathologic complete response (pCR) to a taxane and anthracycline regimen...
  68. pmc Use of immunohistochemical markers can refine prognosis in triple negative breast cancer
    Marc Tischkowitz
    Program in Cancer Genetics, McGill University, Montreal, Quebec, Canada
    BMC Cancer 7:134. 2007
    ..The IHC pattern that best defines basal-like tumors is under investigation and various combinations of ER, PR, HER2-, CK5/6+ and EGFR+ have been tested...
  69. ncbi Levels of hypoxia-inducible factor-1 alpha during breast carcinogenesis
    R Bos
    Department of Pathology, Free University Hospital, Amsterdam, The Netherlands
    J Natl Cancer Inst 93:309-14. 2001
    ..Increased levels of HIF-1 alpha are associated with increased proliferation and increased expression of ER and VEGF. Thus, increased levels of HIF-1 alpha are potentially associated with more aggressive tumors...
  70. ncbi Production and actions of estrogens
    Christian J Gruber
    Department of Gynecologic Endocrinology and Reproductive Medicine, University of Vienna Medical School, Vienna, Austria
    N Engl J Med 346:340-52. 2002
  71. ncbi Nongenotropic, sex-nonspecific signaling through the estrogen or androgen receptors: dissociation from transcriptional activity
    S Kousteni
    Division of Endocrinology and Metabolism, Center for Osteoporosis and Metabolic, Bone Diseases, University of Arkansas for Medical Sciences and, the Central Arkansas Veterans Health Care, System, Little Rock, AR 72205, USA
    Cell 104:719-30. 2001
    ....
  72. ncbi Biological processes associated with breast cancer clinical outcome depend on the molecular subtypes
    Christine Desmedt
    Medical Oncology Department, Jules Bordet Institute
    Clin Cancer Res 14:5158-65. 2008
    ..Here we aimed to perform a comprehensive meta-analysis integrating both clinicopathologic and gene expression data, focusing on the main molecular subtypes...
  73. ncbi Prognostic significance of basal-like phenotype and fascin expression in node-negative invasive breast carcinomas
    Socorro Maria Rodriguez-Pinilla
    Breast and Gynecological Cancer Group, Molecular Pathology Programme and Department of Human Genetics, Centro Nacional de Investigaciones Oncologicas, Madrid, Spain
    Clin Cancer Res 12:1533-9. 2006
    ..The aim of this study was to determine whether basal-like phenotype and fascin were related in both sporadic and familial tumors and with prognosis in node-negative sporadic breast cancers...
  74. ncbi The G protein-coupled receptor GPR30 mediates c-fos up-regulation by 17beta-estradiol and phytoestrogens in breast cancer cells
    Marcello Maggiolini
    Department of Pharmaco Biology, University of Calabria, 87030 Rende CS, Italy
    J Biol Chem 279:27008-16. 2004
    ..estrogen effects cannot be explained by the classic model of hormone action, which involves the binding to estrogen receptors (ERs) alpha and ERbeta and the interaction of the steroid-receptor complex with specific DNA sequences ..
  75. ncbi Molecular changes in tamoxifen-resistant breast cancer: relationship between estrogen receptor, HER-2, and p38 mitogen-activated protein kinase
    M Carolina Gutierrez
    Breast Center and Department of Pathology, Baylor College of Medicine, Houston, TX, USA
    J Clin Oncol 23:2469-76. 2005
    ..To evaluate growth factor receptor cross talk with the estrogen receptor (ER) in paired clinical breast cancer specimens and in a xenograft model before tamoxifen and at tumor progression as a possible mechanism for tamoxifen resistance...
  76. ncbi Biology of progesterone receptor loss in breast cancer and its implications for endocrine therapy
    Xiaojiang Cui
    Breast Center, Baylor College of Medicine, Houston, TX 77030, USA
    J Clin Oncol 23:7721-35. 2005
    ..Finally, we will consider the clinical implications of these observations...
  77. ncbi Observer variation in immunohistochemical analysis of protein expression, time for a change?
    T Kirkegaard
    Endocrine Cancer Group, Division of Cancer Studies and Molecular Pathology, University Department of Surgery, Glasgow Royal Infirmary, Glasgow, UK
    Histopathology 48:787-94. 2006
    ..Interobserver variation is rarely analysed despite recognition that this is a key area of potential inaccuracy. Therefore our aim was to examine observer variation and suggest the revision of current standards...
  78. ncbi Deletion of estrogen receptors reveals a regulatory role for estrogen receptors-beta in bone remodeling in females but not in males
    N A Sims
    Department of Orthopaedics, Yale University School of Medicine, New Haven, CT 06520 8044, USA
    Bone 30:18-25. 2002
    ..Thus, only ERalpha was shown to regulate bone remodeling in males, whereas in females both receptor subtypes influenced this process and could, at least under basal knockout conditions, compensate for each other...
  79. pmc An estrogen receptor-selective coregulator that potentiates the effectiveness of antiestrogens and represses the activity of estrogens
    M M Montano
    Department of Molecular and Integrative Physiology, University of Illinois and College of Medicine, Urbana, IL 61801 3704, USA
    Proc Natl Acad Sci U S A 96:6947-52. 1999
    ....
  80. ncbi Basal-like breast cancer defined by five biomarkers has superior prognostic value than triple-negative phenotype
    Maggie C U Cheang
    Genetic Pathology Evaluation Centre, Vancouver Coastal Health Research Institute, British Columbia Cancer Agency, and University of British Columbia, Vancouver, British Columbia, Canada
    Clin Cancer Res 14:1368-76. 2008
    ..This study directly compares the prognostic significance between three- and five-biomarker surrogate panels to define intrinsic breast cancer subtypes, using a large clinically annotated series of breast tumors...
  81. pmc Plasma membrane estrogen receptors
    Ellis R Levin
    Division of Endocrinology, Veterans Affairs Medical Center, Long Beach, Long Beach, CA 90822, USA
    Trends Endocrinol Metab 20:477-82. 2009
    ..b>Estrogen receptors (ER) have been localized to the plasma membrane where both ERalpha and ERbeta function in a wide variety of ..
  82. ncbi Identification of molecular apocrine breast tumours by microarray analysis
    Pierre Farmer
    Swiss Institute of Bioinformatics, Lausanne, Switzerland
    Oncogene 24:4660-71. 2005
    ..Our data show that it is possible with microarray data to divide mammary tumour cells into three groups based on steroid receptor activity: luminal (ER+ AR+), basal (ER- AR-) and molecular apocrine (ER- AR+)...
  83. pmc An immune response gene expression module identifies a good prognosis subtype in estrogen receptor negative breast cancer
    Andrew E Teschendorff
    Breast Cancer Functional Genomics Laboratory, Cancer Research UK Cambridge Research Institute and Department of Oncology, University of Cambridge, Robinson Way, Cambridge CB2 0RE, UK
    Genome Biol 8:R157. 2007
    ..Reliable identification of ER-negative tumors that have a good prognosis is not yet possible...
  84. ncbi Molecular characterization of three estrogen receptor forms in zebrafish: binding characteristics, transactivation properties, and tissue distributions
    Arnaud Menuet
    Endocrinologie Moleculaire de la Reproduction, UMR CNRS 6026, Campus de Beaulieu, 35042 Rennes Cedex, France
    Biol Reprod 66:1881-92. 2002
    ..The characterization of these zfERs provides a new perspective for understanding the mechanisms underlying estradiol actions in a vertebrate species commonly used for developmental studies...
  85. ncbi Validation of gene signatures that predict the response of breast cancer to neoadjuvant chemotherapy: a substudy of the EORTC 10994/BIG 00-01 clinical trial
    Herve Bonnefoi
    Geneva University Hospital, Geneva, Switzerland
    Lancet Oncol 8:1071-8. 2007
    ..The aim of this study was to confirm the validity of these gene-expression signatures in a large series of patients with oestrogen-receptor-negative breast tumours who were treated in a phase III neoadjuvant clinical trial...
  86. ncbi Mammary gland development and tumorigenesis in estrogen receptor knockout mice
    W P Bocchinfuso
    Receptor Biology Section, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    J Mammary Gland Biol Neoplasia 2:323-34. 1997
    ..These studies provide the impetus to evaluate the effect of other oncogenes in mammary tumorigenesis in the absence of estrogen/ER signaling...
  87. ncbi Human estrogen receptor beta-gene structure, chromosomal localization, and expression pattern
    E Enmark
    Center for Biotechnology, Novum, Huddinge, Sweden
    J Clin Endocrinol Metab 82:4258-65. 1997
    ..In addition, we find ER beta in ovarian granulosa cells, indicating that estrogens also participate in the regulation of follicular growth in the human...
  88. ncbi Triple-negative breast cancer: therapeutic options
    Susan Cleator
    Oncology Department, St Mary s Hospital Trust, London, UK
    Lancet Oncol 8:235-44. 2007
    ....
  89. ncbi Breast cancer incidence, 1980-2006: combined roles of menopausal hormone therapy, screening mammography, and estrogen receptor status
    Andrew G Glass
    Oncology Research, Center for Health Research, Kaiser Permanente Northwest, 3800 N Interstate Ave, Portland, OR 97227, USA
    J Natl Cancer Inst 99:1152-61. 2007
    ..We examined the potential association between menopausal hormone therapy use and recent changes in breast cancer incidence...
  90. ncbi Synergistic activation of functional estrogen receptor (ER)-alpha by DNA methyltransferase and histone deacetylase inhibition in human ER-alpha-negative breast cancer cells
    X Yang
    The Johns Hopkins Oncology Center, Johns Hopkins University, Baltimore, Maryland 21231, USA
    Cancer Res 61:7025-9. 2001
    ..These data suggest that the activities of both DNMT1 and HDAC are key regulators of methylation-mediated ER gene silencing...
  91. pmc Constitutive activation of NF-kappaB during progression of breast cancer to hormone-independent growth
    H Nakshatri
    Department of Surgery, Indiana University School of Medicine, Indianapolis 46202, USA
    Mol Cell Biol 17:3629-39. 1997
    ....
  92. ncbi Common variants on chromosome 5p12 confer susceptibility to estrogen receptor-positive breast cancer
    Simon N Stacey
    deCODE Genetics, Sturlugata 8, 101 Reykjavik, Iceland
    Nat Genet 40:703-6. 2008
    ..The nearest gene, MRPS30, was previously implicated in apoptosis, ER-positive tumors and favorable prognosis. A recently reported signal in FGFR2 was also found to associate specifically with ER-positive breast cancer...
  93. ncbi Estrogen attenuates the MPTP-induced loss of dopamine neurons from the mouse SNc despite a lack of estrogen receptors (ERalpha and ERbeta)
    Paul J Shughrue
    Department of Neuroscience, Merck Research Laboratories, West Point, PA 19486, USA
    Exp Neurol 190:468-77. 2004
    ..Interestingly, estrogen receptors (ERalpha and ERbeta) are thought to be sparse or absent in mouse striatum and SNc...
  94. ncbi An estrogen receptor-negative breast cancer subset characterized by a hormonally regulated transcriptional program and response to androgen
    A S Doane
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Oncogene 25:3994-4008. 2006
    ..This subset of BCs, characterized by a hormonally regulated transcriptional program and response to androgen, suggests the potential for therapeutic strategies targeting the androgen signaling pathway...
  95. pmc Reduced fat mass in mice lacking orphan nuclear receptor estrogen-related receptor alpha
    Jiangming Luo
    Molecular Oncology Group, Department of Medicine, McGill University Health Centre, 687 Pine Avenue West, Montreal, Quebec, Canada H3A 1A1
    Mol Cell Biol 23:7947-56. 2003
    ..This study suggests that ERRalpha functions as a metabolic regulator and that the ERRalpha-/- mice provide a novel model for the investigation of metabolic regulation by nuclear receptors...
  96. pmc Genomic grade index is associated with response to chemotherapy in patients with breast cancer
    Cornelia Liedtke
    DPhil, Departments of Breast Medical Oncology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    J Clin Oncol 27:3185-91. 2009
    ....
  97. ncbi Biologic and clinical characteristics of breast cancer with single hormone receptor positive phenotype
    Emad A Rakha
    Department of Histopathology and Surgery, School of Molecular Medical Sciences, Nottingham University Hospitals National Health Service Trust and University of Nottingham, Nottingham, United Kingdom
    J Clin Oncol 25:4772-8. 2007
    ..It is usually easier to decide treatment strategies in cases of double-positive/-negative phenotypes than in single-positive tumors...
  98. ncbi Cofactor dynamics and sufficiency in estrogen receptor-regulated transcription
    Y Shang
    Boston, MA, USA
    Cell 103:843-52. 2000
    ....
  99. ncbi Gene expression of estrogen receptor, progesterone receptor and microtubule-associated protein Tau in high-risk early breast cancer: a quest for molecular predictors of treatment benefit in the context of a Hellenic Cooperative Oncology Group trial
    George Pentheroudakis
    Department of Medical Oncology, Ioannina University Hospital, Ioannina, Greece
    Breast Cancer Res Treat 116:131-43. 2009
    ..We sought to study the predictive significance and correlations of transcriptional profiling of the ER, PgR and microtubule-associated protein Tau (MAP-Tau) genes in early breast cancer...
  100. ncbi The expression and function of estrogen receptor alpha and beta in human breast cancer and its clinical application
    S I Hayashi
    Division of Endocrinology, Saitama Cancer Center Research Institute, 818 Komuro, Ina machi, Saitama 362 0806, Japan
    Endocr Relat Cancer 10:193-202. 2003
    ..These studies could provide new clues for the elucidation of the estrogen-dependent mechanisms of cancer and the clinical benefits for patients...
  101. ncbi Quantitative association between HER-2/neu and steroid hormone receptors in hormone receptor-positive primary breast cancer
    Gottfried Konecny
    Division of Hematology Oncology, Department of Medicine, and Jonsson Comprehensive Cancer Center, University of California at Los Angeles School of Medicine, Los Angeles 90095 1678, USA
    J Natl Cancer Inst 95:142-53. 2003
    ..To better understand the relationship between HER-2/neu positivity and HR expression, we analyzed HER-2/neu, ER, and PR as continuous variables in breast cancer cell lines and two cohorts of primary breast cancer patients...

Research Grants71

  1. Xenoestrogen regulation of Leydig cells
    BENSON TOKUNBO AKINGBEMI; Fiscal Year: 2010
    ..isoflavones possess estrogenic properties, and reproductive tract tissues (including Leydig cells) express estrogen receptors (ER1 and ER2). Leydig cells are the predominant source of the male sex steroid hormone testosterone...
  2. Hypothalamic Orexin Role in Menopause-Associated Hot Flashes and Mood/Sleep Disru
    PHILIP LEE JOHNSON; Fiscal Year: 2013
    ..role in thermoregulation, and that the orexin system is located in a hypothalamic area enriched in both estrogen receptors, led to my current hypothesis that "the orexin system plays a critical role in menopause-related symptoms ..
  3. 5-HT transporter function: Interaction of hormones and antidepressants
    Alan Frazer; Fiscal Year: 2013
    ..was obtained that these effects of estradiol are mediated via activation of membrane as well as nuclear estrogen receptors (ER). By contrast, the effect of progesterone seems to be mediated primarily by nuclear receptors...
  4. Plant-Derived Estrogens and Cell Proliferation
    Emma Shtivelman; Fiscal Year: 2011
    ..A key to developing safer estrogens for HT is to target specific estrogen receptors (ER) in various tissues. There are two ER subtypes, ERa and ERb...
  5. Estrogen Modulation of Auditory Processing
    Raphael Pinaud; Fiscal Year: 2012
    ..High levels of aromatase and estrogen receptors are found in NCM. E2 levels also rapidly increase in NCM with socially-relevant auditory experiences...
  6. Mitochondrial and Nuclear Mechanisms of Estrogen Receptor-Mediated Cardioprotecti
    DONNA HOPE KORZICK; Fiscal Year: 2012
    ..If our hypothesis on estrogen receptors is correct, new therapeutic targets for the treatment of ischemic cardiovascular disease in the aged ..
  7. Regulation of vasculature by estrogen receptors during aging in mouse models
    Margaret Markiewicz; Fiscal Year: 2013
    ..In our study we investigated the role of estrogen receptors in the process of new vessel formation using female ER?? and ER?? knockout mice...
  8. Environmental regulation of estrogen dependent aggression
    Brian C Trainor; Fiscal Year: 2013
    ..A variety of estrogen receptors (ER) and signaling pathways make up a complex regulatory network that produces intriguing examples of ..
  9. Novel treatment of menopausal hot flushes with an estradiol prodrug
    Laszlo Prokai; Fiscal Year: 2012
    ..two rat models of hot flush, (iii) provide evidence that the beneficial actions of Q-E2 are mediated via estrogen receptors, and (iv) confirm the lack of action in the uterus and breast, and the beneficial effects in the bone ..
  10. Endocrine Targets for Prevention of Lung Cancer
    Robert M Bigsby; Fiscal Year: 2012
    ..Lung cells express all three of the estrogen receptors;they also express progesterone receptor (PR), another nuclear, ligand activated transcription factor...
  11. Vascular Surgery - Estrogen and the Injury Response
    Richard H Karas; Fiscal Year: 2012
    ..direct effects of estrogen on the vasculature are mediated by two ligand-activated transcription factors, estrogen receptors ER1 and ER2...
  12. Genes and Hormonal Fetal Antecedents to Sex Differencs in the Brain in Depression
    Jill M Goldstein; Fiscal Year: 2011
    ..circuitry development and MOD (cortiocotropin releasing hormone (CRH), BDNF, GABA, GLU, neuronal NO (nNOS), estrogen receptors (ER)a and p, and arginine vasopressin (AVP))...
  13. Non-Hodgkin lymphoma in women: reproductive, hormonal and genetic factors
    Paige M Bracci; Fiscal Year: 2011
    ..SNPs in sex-hormone genes of interest include estrogen receptors (ESR), cytochrome P450 17A1 (CYP17A1), sex-hormone binding globulin (SHBG) and catechol-O-methyltransferase (..
  14. Regulation Of Inorganic Phosphorus (Pi) Metabolism By Estrogen
    Hassane Amlal; Fiscal Year: 2013
    ..We will use the pharmacological agonists as well as mice with genetic deletion of estrogen receptors ER? or ER?...
  15. Role of Estrogen Receptors in Lupus-Modulators of the Inflammatory Response
    Gary S Gilkeson; Fiscal Year: 2013
    ..abstract_text> ..
  16. Regulation of Ovarian Cancer Multidrug Resistance by MAP Kinases
    Scott T Eblen; Fiscal Year: 2013
    ..Define the role o estrogen receptors in SPF45-mediated drug resistance...
  17. Sex Differences and Estrogen Receptors Regulate Dendritic Cells in Inflammation
    Susan Kovats; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): SEX DIFFERENCES AND ESTROGEN RECEPTORS REGULATE DENDRITIC CELLS IN INFLAMMATION Abstract Autoimmune diseases such as rheumatoid arthritis and multiple sclerosis are strongly female biased, yet the ..
  18. Interaction of Estrogen and AMPK in the Hypothalamus
    Jessica Healy; Fiscal Year: 2012
    ..of these neuropeptides appear to be estrogen-regulated and neurons expressing these peptides also express estrogen receptors. NPY, AgRP, and POMC are also regulated by the cellular energy sensing enzyme AMP-activated protein kinase (..
  19. Molecular Mechanisms of Genistein in the Prevention of Inflammatory Cytokine (TNF
    Zhenquan Jia; Fiscal Year: 2010
    ..which is not related to any known genistein action such as inhibition of tyrosine kinase or binding to estrogen receptors. Our working hypothesis is that genistein, at physiological concentrations, suppresses TNF-alpha-induced ..
  20. Mechanisms of vascular-specific gene regulation by estrogen
    Gavin R Schnitzler; Fiscal Year: 2013
    ..The functions of estrogen in the vasculature and other tissues are mediated by the estrogen receptors (ERs) alpha and beta (ER[unreadable] &ER[unreadable])...
  21. Mechanisms for the evolution of novel DNA specificity in a transcription factor f
    Joseph W Thornton; Fiscal Year: 2013
    ..The two classes of SRs-estrogen receptors on one hand and the receptors for androgens, progestagens, glucocorticoids, and mineralocorticoids (APGMRs) ..
  22. Estrogen-T cell Interactions
    Prakash S Nagarkatti; Fiscal Year: 2013
    ..of xenoestrogens which include environmental estrogens and phytoestrogens have been identified which bind estrogen receptors (ERs) and mediate activity similar to physiological estrogens...
  23. Impact of Estrogens and Menopause on Interacting Monoamine Neurotransmitters in t
    Jeffrey K Yao; Fiscal Year: 2013
    ..decreases in specific monoaminergic pathways in the brain, and that selective agonists acting at specific estrogen receptors can reverse these effects and restore the neurotransmitter pathways to a physiologically normal state...
  24. Sex-specific gene regulation of neuronal chloride co-transporter, kcc2
    WOLFGANG B LIEDTKE; Fiscal Year: 2010
    ....
  25. Effects of Bisphenol A Exposure on Genomic Imprinting in the Mouse
    Martha Susiarjo; Fiscal Year: 2012
    ..Although BPA-induced effects are thought to arise from its estrogen-like properties and ability to bind to estrogen receptors, the exact molecular mechanisms are unclear...
  26. TNRF1 Signaling Resistance in Ischemic Human Female Myocardium
    Daniel R Meldrum; Fiscal Year: 2010
    ..ischemia, and if so, whether resistance is mediated by endogenous estrogen activation of alpha or beta estrogen receptors;2) TNFR1 signaling resistance in female myocardium is mediated by estrogen receptor stimulation of ..
  27. BETA ENDORPHIN NEURONS AND THE CONTROL OF HOMEOSTASIS
    Martin Kelly; Fiscal Year: 2009
    ..It has been suggested that the classical estrogen receptors ER and ER, and possibly different splice variants, acting through rapid and long term genomic mechanisms are ..
  28. BETA ENDORPHIN NEURONS AND THE CONTROL OF HOMEOSTASIS
    MARTIN JEFFREY KELLY; Fiscal Year: 2013
    ..It has been suggested that the classical estrogen receptors ER and ER, and possibly different splice variants, acting through rapid and long term genomic mechanisms are ..
  29. Sex Hormones and Visceral Hypersensitivity
    Elie D Al-Chaer; Fiscal Year: 2012
    ..hormones modulate i) visceral sensitivity, and ii) central neural sensitization, iii) via direct action on estrogen receptors located on PSDC neurons or iv) via regulation of glutamate receptors located on these neurons...
  30. 5-HT transporter function: Interaction of antidepressants and hormones
    Alan Frazer; Fiscal Year: 2013
    ..was obtained that these effects of estradiol are mediated via activation of membrane as well as nuclear estrogen receptors (ER), indicating a genomic as well as a non-genomic component to these effects...
  31. Cognition in Rhesus Macaques in Relation to Age and Endocrine Status
    Henryk F Urbanski; Fiscal Year: 2013
    ..negatively impacts brain function, either directly through androgen receptors and/or indirectly through estrogen receptors. Using the rhesus macaque as a translational animal model, we propose to test the hypothesis that age-..
  32. THE ROLE FOR THE GPR30 RECEPTOR IN INFLAMMATORY PAIN
    Jill C Fehrenbacher; Fiscal Year: 2010
    ..Because the pharmacology of the GPR30 distinguishes it from other estrogen receptors, the findings here may provide an opportunity for the development of therapeutics which can selectively ..
  33. Gender differences in aortic baroreceptor function and neural integration
    John H Schild; Fiscal Year: 2013
    ..Physiological levels of E2 (0.1 - 1 nM) acting, at least in part, via membrane bound estrogen receptors can selectively increase the excitability of this ABN subtype in female rats...
  34. Regulation of dendritic cells by estrogen receptors during influenza infection
    Susan Kovats; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Regulation of dendritic cells by estrogen receptors during influenza infection Abstract Influenza virus infections result in significant morbidity and mortality in the human population, and the recent ..
  35. Control of Nociception in the Spinal Cord
    Sukhbir S Mokha; Fiscal Year: 2013
    ..of receptors and signaling machinery, as well as non-genomic mechanisms, via membrane-associated estrogen receptors. Aim 1 uses behavioral techniques to determine whether estrogen differentially regulates the antinociceptive ..
  36. Somatic hypermutation and class switching in autoimmunity
    Paolo Casali; Fiscal Year: 2013
    ..also contend that estrogen greatly enhances CD154:CD40-induced HoxC4 expression by triggering the binding of estrogen receptors (ERs) to two conserved estrogen responsive elements (EREs) we have recently identified in the HoxC4 promoter,..
  37. Interatction of Estrogen, Age and Activity on Musculoskeletal Strength in Females
    Dawn A Lowe; Fiscal Year: 2013
    ..hypothesis that the beneficial effects of estradiol on myosin and muscle function are mediated by nuclear estrogen receptors, which regulate oxidative stress-related genes...
  38. Neurobiology of Aggression Co-morbidity in Mouse Model of Idic15 Autism
    Matthew P Anderson; Fiscal Year: 2013
    ..that excess Ube3a in idic15 individuals and in our mouse model of the disorder causes abnormally strong estrogen receptors signaling during the key period of brain development to hypermasculinize the brain generating excess ..
  39. Endocrine Disruptors: Assessment of endocrine disruption activity, mechanism and
    Subhrangsu Mandal; Fiscal Year: 2010
    ..HOXC13 promoter contains multiple estrogen response elements (EREs) to which estrogen receptors (ER: ERa and ER[unreadable]) bind during E2-mediated gene activation...
  40. Actions of Estrogen on Uterine Artery Endothelium
    DongBao Chen; Fiscal Year: 2010
    The hypothesis of this renewal grant is that, on binding to estrogen receptors (i.e., ERa and ER(3) on the plasma membranes, estrogen rapidly activates receptor subtype-specific intracellular signaling pathways (i.e...
  41. Roles of MLL histone methyalses in estrogen mediated regulation of HDLR-SRB1
    Subhrangsu Mandal; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): The estrogen receptors (ERs) are key players in estrogen signaling...
  42. Effect of chronic alcohol on ischemic injury and endothelial cells
    Raj Kishore; Fiscal Year: 2013
    ..survival of both EPCs and mature endothelial cells (EC);interferes with genomic and non-genomic functions of estrogen receptors and switches the E2-mediated cell survival signaling to the induction of pro-apoptotic signaling...
  43. MOLECULAR PROBES FOR STEROID RECEPTORS
    John A Katzenellenbogen; Fiscal Year: 2012
    ..will apply advanced fluorescence methodologies to study the conformational dynamics and interactions of the estrogen receptors ERa and ERI3 and their interactions with coregulator proteins and how these are modulated by various ER ..
  44. Estradiol, MCH and Food Intake
    Jessica C Santollo; Fiscal Year: 2010
    ..My working hypothesis is that estradiol acts via nuclear estrogen receptors (ERs) to decrease MCH signaling and, as a consequence, decreases food intake...
  45. Mechanisms of Breast Tumor Cell Growth, Motility, and Antiestrogen Response
    Amy H Bouton; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Estrogen and the estrogen receptors (ERs) are critical regulators of breast epithelial cell proliferation, differentiation, and apoptosis...
  46. Sex-specific Regulation of Acute Inflammation and Resolution
    Karsten Gronert; Fiscal Year: 2013
    ..II. Elucidate the role of the estrogen receptors (ER[unreadable] and ER[unreadable]) in the regulation of corneal epithelial and leukocyte wound healing ..
  47. Steroid Catecholamine Interactions and Behavior
    Gregory F Ball; Fiscal Year: 2013
    ..For example, there is evidence that estrogen receptors embedded in the cell membrane interact with receptors for the excitatory amino acid receptor glutamate...
  48. Molecular Mechanisms &Importance of Oxidative Stress in Estrogen-Induced Carcino
    Hari K Bhat; Fiscal Year: 2011
    ..will characterize: the role of estrogen metabolism-mediated oxidative stress (Specific Aim 1);the role of estrogen receptors (ERs) in the generation of oxidative stress (Specific Aim 2);the role of oxidative stress in modifying ER-..
  49. Estrogen-Induced Hippocampal Seizure Susceptibility
    Catherine S Woolley; Fiscal Year: 2013
    ..small vesicles and some large dense core vesicles in inhibitory presynaptic boutons are immunoreactive for estrogen receptors. This suggests that estradiol exerts its effects on release of GABA and neuropeptide Y by acting at the ..
  50. Estrogen receptors in benign prostatic hyperplasia
    TRISTAN MARRINER NICHOLSON; Fiscal Year: 2013
    ..The goal of this fellowship research will be to elucidate the ER underlying induction of these effects in this mouse model and evaluate SERMs as potential therapies for BPH. ..
  51. Fourth Annual OSSD Meeting
    Jill B Becker; Fiscal Year: 2010
    ..Sex-based Differences in Respiratory System Ontogeny and Function;Sexually Differentiated Responses and Estrogen Receptors;Sex Differences in Neuroplasticity during Development and in Adults;and Sex Differences in Oxidative Stress, ..
  52. Regulation of GPER-mediated Signaling in the Vasculature by Calmodulin
    Kim Tran; Fiscal Year: 2012
    ..CaM both at the receptor level and downstream effectors, linking signaling pathways mediated by different estrogen receptors. Effects of GPER activation will also be tested on endothelial Ca2+ signaling and cell-cell interaction via ..
  53. Estrogen regulation of inflammatory mediator signaling
    William P Clarke; Fiscal Year: 2011
    ..Detailed study of estrogen receptors and their effects on inflammatory mediator signaling in TG will provide a basis for understanding the ..
  54. Molecular Mechanisms of Endocrine Disruption in Bass
    Nancy D Denslow; Fiscal Year: 2011
    ..In past research, we have identified three estrogen receptors (a, pi, and (32) in largemouth bass, which exhibit tissue specific expression and respond differently to 17-..
  55. LRH-1 Antagonism: Impact on Estrogen-dependent Breast Cancer
    Marcia I Dawson; Fiscal Year: 2013
    ..abstract_text> ..
  56. Non-cancer gene addition as anticancer strategy
    Jose M Silva; Fiscal Year: 2012
    ..The successful completion of this research plan will provide us with novel targets for more efficient and less harmful breast cancer therapies and it may impact the design of future generation of cancer treatments. ..
  57. Prevention of estrogen-mediated mammary carcinogenesis by mixtures of tocopherols
    Nanjoo Suh; Fiscal Year: 2013
    ..3. Elucidate the molecular mechanisms of action of tocopherols in modulating estrogen receptors (ERs) and PPAR?, resulting in suppressing cell proliferation and cell survival in cell lines. 4...
  58. NEUROCHEMICAL MECHANISMS OF VISCERAL PAIN
    Richard J Traub; Fiscal Year: 2013
    ..Specific Aim 1 will test the hypotheses that [1] estrogen receptors modulate colorectal sensory processing at the level of the spinal cord and that [2] the two isoforms of the ..
  59. Ligand-independent signaling of estrogen receptor beta and the aging brain
    Toni R Pak; Fiscal Year: 2013
    ..Estrogen signaling in the brain is conveyed by two high specificity receptors, estrogen receptors alpha and beta (ER1, ER2)...
  60. Sexually dimorphic effects of endocrine disruptors on brain &behavior
    Andrea C Gore; Fiscal Year: 2013
    ..Many effects of EDCs are mediated by hormone receptors such as estrogen receptors (ERs) that are widely distributed in the brain, and thereby EDCs perturb neurobiological functions...
  61. FLOW EFFECTS ON ENDOTHELIAL/TROPHOBLAST INTERACTION
    Gordon C Douglas; Fiscal Year: 2013
    ..epidermal growth factor receptor (ErbB1) (3) FSS-mediated upregulation of [unreadable]1 integrin involves estrogen receptors (ERs), and (4) FSS causes accumulation of ER[unreadable] in nuclei and this is not seen when MUC1 expression ..
  62. Identification of novel phytoprogestins from hops and red clover
    Joanna E Burdette; Fiscal Year: 2011
    ..Two common supplements, hops and red clover, contain phytoestrogens that bind and activate estrogen receptors. Interestingly, when hops and red clover are given orally to ovariectomized rats, uterine weights are not ..
  63. Restraint stress-induced neurogenic bladder inflammation
    Theoharis Theoharides; Fiscal Year: 2006
    ..pretreatment of bladder with estradiol increased the stimulatory effect of SP, by activating high affinity estrogen receptors that we have identified on bladder mast cells...
  64. Effects of herbs on transcription and cell proliferation
    Dale Leitman; Fiscal Year: 2003
    ..whereby SERMs prevent breast cancer is unknown, it is clear that SERMs interact directly with two known estrogen receptors, ER-alpha and ER-beta...
  65. RADIOPHARMACEUTICALS FOR BREAST TUMOR IMAGING & THERAPY
    John Katzenellenbogen; Fiscal Year: 2006
    Most breast tumors contain estrogen receptors (ER) that regulate tumor cell growth and mediate the action of estrogen antagonists such as tamoxifen. Not all breast cancers, however, respond to hormone therapy...
  66. Temporomandibular joint syndrome in females
    Nancy Berman; Fiscal Year: 2005
    ..of this application is that ovarian steroids regulate the phenotype of trigeminal neurons by acting upon estrogen receptors during the natural estrous cycle, following ovariectomy and during pregnancy...
  67. Female Hormones and Vision
    Alvin Eisner; Fiscal Year: 2006
    ..is expected to provide quantitative means of assessing duration-dependent effects of medications that affect estrogen receptors or that alter estrogen levels...
  68. Do estrogen receptors in B cells and DC mediate sex bias in murine lupus?
    Susan Kovats; Fiscal Year: 2009
    ..underlying the female preponderance of SLE requires that we precisely determine how endogenous estrogens and estrogen receptors (ER) regulate the function of immune cells such as B lymphocytes and dendritic cells (DC), which express ER ..
  69. Interactions Between Dietary Soy Components & Tamoxifen
    Jin Rong Zhou; Fiscal Year: 2003
    ....
  70. Estrogen Metabolism and Action in Prostate Cancer Etiology in PCPT
    Ashraful Hoque; Fiscal Year: 2007
    ..Two estrogen receptors, ESR-a (ESR1) and ESR-3 (ESR2), are present in the human prostate and are the principal mediators of ..
  71. Transgenic Models of Estrogen Receptor Activity in Bone
    Joseph Alexander; Fiscal Year: 2004
    ..However, the relative roles of the two known estrogen receptors (ERs), alpha and beta, and their bone-specific mechanisms of action continue to be debated...