androgen receptors

Summary

Summary: Proteins, generally found in the cytoplasm, that specifically bind androgens and mediate their cellular actions. The complex of the androgen and receptor migrates to the nucleus where it induces transcription of specific segments of DNA.

Top Publications

  1. ncbi The development of androgen-independent prostate cancer
    B J Feldman
    Department of Medicine, Stanford University School of Medicine, California 94305 5103, USA
    Nat Rev Cancer 1:34-45. 2001
  2. ncbi Molecular determinants of resistance to antiandrogen therapy
    Charlie D Chen
    Department of Medicine, University of California at Los Angeles, Los Angeles, California 90095, USA
    Nat Med 10:33-9. 2004
  3. ncbi Androgen receptor in prostate cancer
    Cynthia A Heinlein
    George Whipple Laboratory for Cancer Research, Department of Pathology, University of Rochester, Rochester, NY 14642, USA
    Endocr Rev 25:276-308. 2004
  4. ncbi Increased expression of genes converting adrenal androgens to testosterone in androgen-independent prostate cancer
    Michael Stanbrough
    Cancer Biology Program, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Cancer Res 66:2815-25. 2006
  5. ncbi Biology of progressive, castration-resistant prostate cancer: directed therapies targeting the androgen-receptor signaling axis
    Howard I Scher
    Genitourinary Oncology Service, Department of Medicine, Sidney Kimmel Center for Prostate and Urologic Cancers, Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10021, USA
    J Clin Oncol 23:8253-61. 2005
  6. pmc A hierarchical network of transcription factors governs androgen receptor-dependent prostate cancer growth
    Qianben Wang
    Division of Molecular and Cellular Oncology, Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, MA 02115, USA
    Mol Cell 27:380-92. 2007
  7. ncbi Amplification and overexpression of androgen receptor gene in hormone-refractory prostate cancer
    M J Linja
    Laboratory of Cancer Genetics, Institute of Medical Technology, University of Tampere and Tampere University Hospital, FIN-33014 Tampere, Finland
    Cancer Res 61:3550-5. 2001
  8. ncbi A mechanism for androgen receptor-mediated prostate cancer recurrence after androgen deprivation therapy
    C W Gregory
    Laboratory for Reproductive Biology, Department of Pediatrics, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA
    Cancer Res 61:4315-9. 2001
  9. ncbi The androgen axis in recurrent prostate cancer
    James L Mohler
    Department of Surgery, Division of Urology, Pathology and Laboratory Medicine, University of North Carolina Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina, USA
    Clin Cancer Res 10:440-8. 2004
  10. ncbi Androgen receptor gene mutations in X-linked spinal and bulbar muscular atrophy
    A R La Spada
    Neurology Department, University of Pennsylvania School of Medicine, Philadelphia 19104 6146
    Nature 352:77-9. 1991

Detail Information

Publications322 found, 100 shown here

  1. ncbi The development of androgen-independent prostate cancer
    B J Feldman
    Department of Medicine, Stanford University School of Medicine, California 94305 5103, USA
    Nat Rev Cancer 1:34-45. 2001
    ....
  2. ncbi Molecular determinants of resistance to antiandrogen therapy
    Charlie D Chen
    Department of Medicine, University of California at Los Angeles, Los Angeles, California 90095, USA
    Nat Med 10:33-9. 2004
    ..These findings provide insight toward the design of new antiandrogens...
  3. ncbi Androgen receptor in prostate cancer
    Cynthia A Heinlein
    George Whipple Laboratory for Cancer Research, Department of Pathology, University of Rochester, Rochester, NY 14642, USA
    Endocr Rev 25:276-308. 2004
    ..The inhibition of AR activity through mechanisms in addition to androgen ablation, such as modulation of signal transduction pathways, may delay prostate cancer progression...
  4. ncbi Increased expression of genes converting adrenal androgens to testosterone in androgen-independent prostate cancer
    Michael Stanbrough
    Cancer Biology Program, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Cancer Res 66:2815-25. 2006
    ..These results indicate that enhanced intracellular conversion of adrenal androgens to testosterone and dihydrotestosterone is a mechanism by which prostate cancer cells adapt to androgen deprivation and suggest new therapeutic targets...
  5. ncbi Biology of progressive, castration-resistant prostate cancer: directed therapies targeting the androgen-receptor signaling axis
    Howard I Scher
    Genitourinary Oncology Service, Department of Medicine, Sidney Kimmel Center for Prostate and Urologic Cancers, Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10021, USA
    J Clin Oncol 23:8253-61. 2005
    ..On the basis of this schema, we discuss strategies that are focused on the AR either directly or indirectly, as single agents or in combination, that are in clinical development...
  6. pmc A hierarchical network of transcription factors governs androgen receptor-dependent prostate cancer growth
    Qianben Wang
    Division of Molecular and Cellular Oncology, Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, MA 02115, USA
    Mol Cell 27:380-92. 2007
    ..These collaborating factors, together with AR, form a regulatory hierarchy that governs androgen-dependent gene expression and prostate cancer growth and offer potential new opportunities for therapeutic intervention...
  7. ncbi Amplification and overexpression of androgen receptor gene in hormone-refractory prostate cancer
    M J Linja
    Laboratory of Cancer Genetics, Institute of Medical Technology, University of Tampere and Tampere University Hospital, FIN-33014 Tampere, Finland
    Cancer Res 61:3550-5. 2001
    ..The two xenografts with the AR gene amplification will enable studies evaluating the functional significance of the amplification and development of new treatment strategies based on high-level expression of AR...
  8. ncbi A mechanism for androgen receptor-mediated prostate cancer recurrence after androgen deprivation therapy
    C W Gregory
    Laboratory for Reproductive Biology, Department of Pediatrics, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA
    Cancer Res 61:4315-9. 2001
    ..Furthermore, we provide a molecular basis for this activation and suggest a general mechanism for recurrent prostate cancer growth...
  9. ncbi The androgen axis in recurrent prostate cancer
    James L Mohler
    Department of Surgery, Division of Urology, Pathology and Laboratory Medicine, University of North Carolina Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina, USA
    Clin Cancer Res 10:440-8. 2004
    ..High levels of expression of androgen receptor and androgen receptor-regulated genes in recurrent prostate cancer suggest a role for androgen receptor and its ligands in prostate cancer recurrence...
  10. ncbi Androgen receptor gene mutations in X-linked spinal and bulbar muscular atrophy
    A R La Spada
    Neurology Department, University of Pennsylvania School of Medicine, Philadelphia 19104 6146
    Nature 352:77-9. 1991
    ..The association is unlikely to be due to linkage disequilibrium, because 11 different disease alleles were observed. We conclude that enlargement of the CAG repeat in the androgen receptor gene is probably the cause of this disorder...
  11. ncbi A mutation in the ligand binding domain of the androgen receptor of human LNCaP cells affects steroid binding characteristics and response to anti-androgens
    J Veldscholte
    Department of Biochemistry II, Erasmus University Rotterdam, The Netherlands
    Biochem Biophys Res Commun 173:534-40. 1990
    ..The mutation therefore influences both binding and the induction of gene expression by different steroids and antisteroids...
  12. ncbi Androgen responsive adult human prostatic epithelial cell lines immortalized by human papillomavirus 18
    D Bello
    Department of Medicine, Michigan State University, East Lansing 48824 1312, USA
    Carcinogenesis 18:1215-23. 1997
    ..The RWPE-1 cells, which show many normal cell characteristics, and the malignant RWPE-2 cells, provide useful cell culture models for studies on prostate growth regulation and carcinogenesis...
  13. ncbi Androgen receptor (AR) coregulators: an overview
    Cynthia A Heinlein
    George Whipple Laboratory for Cancer Research, Department of Pathology, University of Rochester, New York 14642, USA
    Endocr Rev 23:175-200. 2002
    ....
  14. pmc AR, the cell cycle, and prostate cancer
    Steven P Balk
    Cancer Biology Program Hematology Oncology Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
    Nucl Recept Signal 6:e001. 2008
    ..As will be discussed, discrete aberrations in this process can alter the proliferative response to androgen, and potentially subvert hormonal control of tumor progression...
  15. pmc Granulosa cell-specific androgen receptors are critical regulators of ovarian development and function
    Aritro Sen
    Division of Endocrinology and Metabolism, Department of Medicine, University of Rochester Medical Center, Rochester, New York 14642, USA
    Mol Endocrinol 24:1393-403. 2010
    ..These GC-specific ARs appear to promote preantral follicle growth and prevent follicular atresia; thus they are essential for normal follicular development and fertility...
  16. ncbi Molecular characterization of human prostate carcinoma cell lines
    Adrie van Bokhoven
    Department of Pathology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Prostate 57:205-25. 2003
    ..This study presents a comprehensive survey and characterization of available prostate carcinoma cell lines, most of which have been widely used but are incompletely characterized...
  17. pmc Phosphorylation-dependent ubiquitylation and degradation of androgen receptor by Akt require Mdm2 E3 ligase
    Hui Kuan Lin
    George H Whipple Laboratory for Cancer Research, Department of Pathology and The Cancer Center, University of Rochester, Rochester, NY 14642, USA
    EMBO J 21:4037-48. 2002
    ..These results suggest that phosphorylation-dependent AR ubiquitylation and degradation by Akt require the involvement of Mdm2 E3 ligase activity, a novel mechanism that provides insight into how AR is targeted for degradation...
  18. ncbi Mutation of the androgen-receptor gene in metastatic androgen-independent prostate cancer
    M E Taplin
    Department of Medicine, University of Massachusetts Medical Center, Worcester, USA
    N Engl J Med 332:1393-8. 1995
    ..We analyzed the androgen-receptor genes from samples of metastatic androgen-independent prostate cancers to determine whether mutations in the gene have a role in androgen independence...
  19. ncbi Molecular biology of the androgen receptor
    Edward P Gelmann
    Department of Oncology, Lombardi Cancer Center, Georgetown University School of Medicine, 3800 Reservoir Rd NW, Washington, DC 20007 2197, USA
    J Clin Oncol 20:3001-15. 2002
    ..Further understanding of AR action and new strategies to interfere with AR signaling hold promise for improving prostate cancer therapy...
  20. pmc Activated Cdc42-associated kinase Ack1 promotes prostate cancer progression via androgen receptor tyrosine phosphorylation
    Nupam P Mahajan
    Lineberger Comprehensive Cancer Center, Departments of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Proc Natl Acad Sci U S A 104:8438-43. 2007
    ..Targeting the Ack1 kinase may be a potential therapeutic strategy in prostate cancer...
  21. ncbi Regulation of androgen receptor activity by tyrosine phosphorylation
    Zhiyong Guo
    Department of Pharmacology and Experimental Therapeutics, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Cancer Cell 10:309-19. 2006
    ....
  22. ncbi Spatial and temporal recruitment of androgen receptor and its coactivators involves chromosomal looping and polymerase tracking
    Qianben Wang
    Division of Molecular and Cellular Oncology, Department of Medical Oncology, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Mol Cell 19:631-42. 2005
    ..Development of improved hormonal therapies for prostate cancer must take in account the specific spatial and temporal modes of AR-mediated gene regulation...
  23. ncbi Mechanisms of androgen-refractory prostate cancer
    Jose D Debes
    Department of Urology, Mayo Clinic College of Medicine, Rochester, Minn, USA
    N Engl J Med 351:1488-90. 2004
  24. pmc Covalent modification of the androgen receptor by small ubiquitin-like modifier 1 (SUMO-1)
    H Poukka
    Department of Physiology, Institute of Biomedicine, and Department of Clinical Chemistry, University of Helsinki, FIN 00014, Helsinki, Finland
    Proc Natl Acad Sci U S A 97:14145-50. 2000
    ..Taken together, our data suggest that reversible sumoylation is a mechanism for regulation of steroid receptor function...
  25. ncbi Wnt3a growth factor induces androgen receptor-mediated transcription and enhances cell growth in human prostate cancer cells
    Meletios Verras
    Department of Urology, Stanford University School of Medicine, Stanford, California, USA
    Cancer Res 64:8860-6. 2004
    ..Our findings demonstrate that Wnt3a plays an important role in androgen-mediated transcription and cell growth. These results suggest a novel mechanism for the progression of prostate cancer...
  26. pmc The CAG repeat within the androgen receptor gene and its relationship to prostate cancer
    E Giovannucci
    Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 94:3320-3. 1997
    ..The clinical implications of these results should be evaluated further...
  27. ncbi Androgen receptor gene amplification and protein expression in recurrent prostate cancer
    O Harris Ford
    Department of Surgery, Division of Urology, University of North Carolina Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    J Urol 170:1817-21. 2003
    ..AR amplification may contribute to androgen receptor activation in relative androgen absence...
  28. ncbi In vivo knockdown of the androgen receptor results in growth inhibition and regression of well-established, castration-resistant prostate tumors
    Robert Snoek
    Prostate Center at Vancouver General Hospital and Department of Urologic Sciences, University of British Columbia, British Columbia, Canada
    Clin Cancer Res 15:39-47. 2009
    ..We hypothesize that knocking down AR will have a major effect on inhibiting growth of castration-resistant tumors...
  29. ncbi Nongenotropic, sex-nonspecific signaling through the estrogen or androgen receptors: dissociation from transcriptional activity
    S Kousteni
    Division of Endocrinology and Metabolism, Center for Osteoporosis and Metabolic, Bone Diseases, University of Arkansas for Medical Sciences and, the Central Arkansas Veterans Health Care, System, Little Rock, AR 72205, USA
    Cell 104:719-30. 2001
    ....
  30. ncbi Androgen receptor (AR) coregulators: a diversity of functions converging on and regulating the AR transcriptional complex
    Hannelore V Heemers
    Department of Urology Research, Mayo Clinic, Rochester, Minnesota 55905, USA
    Endocr Rev 28:778-808. 2007
    ..Taken together, this approach will increase our understanding of the cellular pathways that converge on the AR to ensure an appropriate transcriptional response to androgens...
  31. ncbi Structural basis for androgen receptor interdomain and coactivator interactions suggests a transition in nuclear receptor activation function dominance
    Bin He
    Laboratories for Reproductive Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Mol Cell 16:425-38. 2004
    ..An activation function transition hypothesis is proposed in which an evolutionary decline in LXXLL motif binding parallels expansion and functional dominance of the NH(2)-terminal transactivation domain in the steroid receptor subfamily...
  32. ncbi Tip60 is a nuclear hormone receptor coactivator
    M E Brady
    Prostate Research Group, Department of Surgery, Medical School, University of Newcastle upon Tyne, Newcastle upon Tyne NE2 4HH, United Kingdom
    J Biol Chem 274:17599-604. 1999
    ..The importance of such proteins in enhancing nuclear hormone receptor-mediated transcriptional activation is widely accepted, and this work suggests that Tip60 may have an equally important role to play...
  33. pmc New androgen receptor genomic targets show an interaction with the ETS1 transcription factor
    Charles E Massie
    Uro Oncology Research Group, Department of Oncology, University of Cambridge, Cancer Research UK Cambridge, Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
    EMBO Rep 8:871-8. 2007
    ..Binding sequences for the avian erythroblastosis virus E26 homologue (ETS) transcription factor family were also highly enriched, and we uncovered an interaction between the AR and ETS1 at a subset of AR promoter targets...
  34. ncbi Mechanisms of androgen receptor activation and function
    A O Brinkmann
    Department of Endocrinology and Reproduction, Erasmus University Rotterdam, The Netherlands
    J Steroid Biochem Mol Biol 69:307-13. 1999
    ..Two regions in the NH2-terminal domain are involved in this interaction, whereas in the ligand-binding domain the AF-2 AD core region is involved...
  35. ncbi Coregulator recruitment and histone modifications in transcriptional regulation by the androgen receptor
    Zhigang Kang
    Biomedicum Helsinki, Institute of Biomedicine, University of Helsinki, FI 00014, Finland
    Mol Endocrinol 18:2633-48. 2004
    ....
  36. pmc Generation and characterization of androgen receptor knockout (ARKO) mice: an in vivo model for the study of androgen functions in selective tissues
    Shuyuan Yeh
    Departments of Urology and Pathology, George H Whipple Lab for Cancer Research, University of Rochester, Rochester, NY 14642, USA
    Proc Natl Acad Sci U S A 99:13498-503. 2002
    ..The cre-lox ARKO mouse provides a much-needed in vivo animal model to study androgen functions in the selective androgen target tissues in female or male mice...
  37. pmc Steroid-induced androgen receptor-oestradiol receptor beta-Src complex triggers prostate cancer cell proliferation
    A Migliaccio
    Istituto di Patologia Generale e Oncologia, Facolta di Medicina e Chirurgia, II Universita di Napoli, Largo S Aniello a Caponapoli 2, 80138 Napoli, Italy
    EMBO J 19:5406-17. 2000
    ..The role of this phosphotyrosine is stressed by its requirement for association of oestradiol receptor alpha with Src and consequent activation of Src in intact Cos cells...
  38. ncbi Establishment and characterization of androgen-independent human prostate cancer LNCaP cell model
    Tsukasa Igawa
    Department of Biochemistry and Molecular Biology, College of Medicine, University of Nebraska Medical Center, Omaha, Nebraska 68198 4525, USA
    Prostate 50:222-35. 2002
    ..To investigate the molecular mechanism of androgen-independent growth of prostate cancer, we established a useful LNCaP cell model that resembles the clinical scenario of hormone-refractory prostate cancer...
  39. ncbi Androgen receptor stabilization in recurrent prostate cancer is associated with hypersensitivity to low androgen
    C W Gregory
    Department of Pediatrics, and Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill 27599, USA
    Cancer Res 61:2892-8. 2001
    ..The results suggest that AR is transcriptionally active in recurrent CaP and can increase cell proliferation at the low circulating levels of androgen reported in castrated men...
  40. ncbi HER2/neu kinase-dependent modulation of androgen receptor function through effects on DNA binding and stability
    Ingo K Mellinghoff
    Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
    Cancer Cell 6:517-27. 2004
    ..Surprisingly, the downstream signaling pathway responsible for these effects appears to involve kinases other than Akt. These data suggest that the HER2/ERBB3 pathway is a critical target in hormone-refractory prostate cancer...
  41. ncbi Beta-catenin affects androgen receptor transcriptional activity and ligand specificity
    C I Truica
    Lombardi Cancer Center, Georgetown University, Washington, DC 20007 2197, USA
    Cancer Res 60:4709-13. 2000
    ..The amount of beta-catenin in complex with AR was increased by androgen. These findings implicate beta-catenin in the regulation of AR function and support a role for beta-catenin mutations in the pathogenesis of prostate cancer...
  42. ncbi Androgen receptor: a key molecule in the progression of prostate cancer to hormone independence
    Mary Ellen Taplin
    Dana Farber Cancer Institute, Boston, Massachusetts 02115 6084, USA
    J Cell Biochem 91:483-90. 2004
    ..Understanding the changes in AR signaling in the evolution of androgen-independent prostate cancer will be key to the development of more effective hormone therapy...
  43. ncbi Novel mutations of androgen receptor: a possible mechanism of bicalutamide withdrawal syndrome
    Takahito Hara
    Pharmaceutical Research Laboratories, Takeda Chemical Industries, Ltd, Osaka 532 8686, Japan
    Cancer Res 63:149-53. 2003
    ..Our data strongly support the hypothesis that AR mutation is one possible mechanism of the AWS and suggest that flutamide might be effective as a second-line therapy for refractory PC previously treated with bicalutamide...
  44. ncbi Nongenomic androgen activation of phosphatidylinositol 3-kinase/Akt signaling pathway in MC3T3-E1 osteoblasts
    Hong Yo Kang
    The Center for Menopause and Reproductive Medicine Research, Chang Gung University Memorial Hospital, Kaohsiung, Taiwan
    J Bone Miner Res 19:1181-90. 2004
    ..siRNA-AR prevented androgen-induced Akt activation in MC3T3-E1 cells. This suggests that nongenomic androgen activation of Akt is mediated by androgen receptor in osteoblasts...
  45. ncbi Recruitment of beta-catenin by wild-type or mutant androgen receptors correlates with ligand-stimulated growth of prostate cancer cells
    David Masiello
    Cancer Biology Program Hematology Oncology Division, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Mol Endocrinol 18:2388-401. 2004
    ..These results indicate that interactions between AR and beta-catenin contribute to prostate cell growth in vivo, although specific growth promoting genes positively regulated by AR recruitment of beta-catenin remain to be identified...
  46. pmc Non-genomic actions of androgens
    C D Foradori
    Department of Biomedical Sciences, Neurobiology Section, Colorado State University, Fort Collins, CO 80523, USA
    Front Neuroendocrinol 29:169-81. 2008
    ..e. non-genomic in nature). In the present paper, the non-genomic effects of androgens are reviewed, along with a discussion of the possible role non-genomic androgen actions have on animal physiology and behavior...
  47. ncbi Short hairpin RNA knockdown of the androgen receptor attenuates ligand-independent activation and delays tumor progression
    Helen Cheng
    The Prostate Center at Vancouver General Hospital, University of British Columbia, Vancouver, British Columbia, Canada
    Cancer Res 66:10613-20. 2006
    ....
  48. pmc Acetylation of androgen receptor enhances coactivator binding and promotes prostate cancer cell growth
    Maofu Fu
    Department of Oncology, Lombardi Cancer Center, Georgetown University, Washington, DC 20057, USA
    Mol Cell Biol 23:8563-75. 2003
    ..Thus, transcription factor acetylation regulates coactivator/corepressor complex binding, altering expression of specific growth control genes to promote aberrant cellular growth in vivo...
  49. ncbi Tip60 and histone deacetylase 1 regulate androgen receptor activity through changes to the acetylation status of the receptor
    Luke Gaughan
    Prostate Research Group, School of Surgical Sciences, University of Newcastle upon Tyne, Medical School, Framlington Place, Newcastle upon Tyne NE2 4HH, United Kingdom
    J Biol Chem 277:25904-13. 2002
    ....
  50. ncbi Molecular regulation of androgen action in prostate cancer
    Scott M Dehm
    Department of Urology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    J Cell Biochem 99:333-44. 2006
    ..We will also summarize several recent studies that have attempted to unravel how these genes are deregulated in androgen depletion independent prostate cancer...
  51. ncbi p300 and p300/cAMP-response element-binding protein-associated factor acetylate the androgen receptor at sites governing hormone-dependent transactivation
    M Fu
    Albert Einstein Cancer Center, Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Biol Chem 275:20853-60. 2000
    ..The identification of the AR as a direct target of histone acetyltransferase co-activators has important implications for targeting inhibitors of AR function...
  52. ncbi Selection for androgen receptor mutations in prostate cancers treated with androgen antagonist
    M E Taplin
    University of Massachusetts Cancer Center, Worcester 01655, USA
    Cancer Res 59:2511-5. 1999
    ..These findings demonstrate that AR mutations occur in response to strong selective pressure from flutamide treatment...
  53. ncbi Androgen receptor structural and functional elements: role and regulation in prostate cancer
    Scott M Dehm
    Departments of Urology and Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, 200 First Street Southwest, Rochester, Minnesota 55905, USA
    Mol Endocrinol 21:2855-63. 2007
    ..A comprehensive understanding of the role and functional relationships between these AR domains could lead to the development of novel AR-directed therapies for prostate cancer...
  54. ncbi Androgen receptor gene amplification: a possible molecular mechanism for androgen deprivation therapy failure in prostate cancer
    P Koivisto
    Laboratory of Cancer Genetics, Institute of Medical Technology, University of Tampere, Finland
    Cancer Res 57:314-9. 1997
    ..Amplification and the increased expression of a wild-type AR gene may play a key role in this process...
  55. ncbi Cloning of human androgen receptor complementary DNA and localization to the X chromosome
    D B Lubahn
    Department of Pediatrics, University of North Carolina, Chapel Hill 27599
    Science 240:327-30. 1988
    ..The deduced amino acid sequence of AR within the DNA-binding domain has highest sequence identity with the progesterone receptor...
  56. ncbi International Union of Pharmacology. LXV. The pharmacology and classification of the nuclear receptor superfamily: glucocorticoid, mineralocorticoid, progesterone, and androgen receptors
    Nick Z Lu
    Molecular Endocrinology Group, Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA
    Pharmacol Rev 58:782-97. 2006
  57. ncbi Cloning and characterization of androgen receptor coactivator, ARA55, in human prostate
    N Fujimoto
    George Whipple Lab for Cancer Research, Departments of Pathology, Urology, and Radiation Oncology, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Biol Chem 274:8316-21. 1999
    ..Together, our data suggests that ARA55 may play very important roles in the progression of prostate cancer by the modulation of AR transactivation...
  58. pmc Androgen receptor and growth factor signaling cross-talk in prostate cancer cells
    Meng Lei Zhu
    Departments of Urology and Toxicology, University of Kentucky College of Medicine, University of Kentucky Medical Center, Combs Research Building Room 306, Lexington, Kentucky 40536, USA
    Endocr Relat Cancer 15:841-9. 2008
    ..The significance of this derailed cross-talk between androgens and key signaling networks in prostate cancer progression and its value as a therapeutic forum targeting androgen-independent metastatic prostate cancer is discussed...
  59. pmc From HER2/Neu signal cascade to androgen receptor and its coactivators: a novel pathway by induction of androgen target genes through MAP kinase in prostate cancer cells
    S Yeh
    George Whipple Laboratory for Cancer Research, Departments of Pathology, Urology, Radiation Oncology, and the Cancer Center, University of Rochester, Rochester, NY 14642, USA
    Proc Natl Acad Sci U S A 96:5458-63. 1999
    ..Together, these data provide a novel pathway from HER2/Neu to AR transactivation, and they may represent one of the reasons for the PSA re-elevation and hormone resistance during androgen ablation therapy in prostate cancer patients...
  60. pmc Comparative studies of the estrogen receptors beta and alpha and the androgen receptor in normal human prostate glands, dysplasia, and in primary and metastatic carcinoma
    I Leav
    Department of Pathology, Schools of Medicine and Veterinary Medicine, Tufts University, Boston, Massachusetts, USA
    Am J Pathol 159:79-92. 2001
    ..Based on our recent finding of anti-estrogen/ER-beta-mediated growth inhibition of prostate cancer cells in vitro, the presence of ER-beta in metastatic cells may have important implications for the treatment of late-stage disease...
  61. pmc Mutation of the androgen receptor causes oncogenic transformation of the prostate
    Guangzhou Han
    Department of Molecular and Cellular Biology, Pathology, and Urology, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 102:1151-6. 2005
    ....
  62. ncbi Glucocorticoids can promote androgen-independent growth of prostate cancer cells through a mutated androgen receptor
    X Y Zhao
    Department of Medicine, Stanford University School of Medicine, Stanford, California 94305, USA
    Nat Med 6:703-6. 2000
    ..Understanding this mechanism and recognizing the presence of glucocorticoid-responsive AR mutants are important for the development of new forms of therapy for the treatment of this subset of CaP...
  63. pmc Mechanisms involved in the progression of androgen-independent prostate cancers: it is not only the cancer cell's fault
    J T Arnold
    National Center for Complementary and Alternative Medicine NCCAM, National Institutes of Health, 8 West Drive MSC 2669, Qtrs 15B1, Bethesda, MD 20892 2669, USA
    Endocr Relat Cancer 9:61-73. 2002
    ....
  64. ncbi Nuclear receptors, intestinal architecture and colon cancer: an intriguing link
    I D'Errico
    Department of Translational Pharmacology, Consorzio Mario Negri Sud, Santa Maria Imbaro, Chieti and Clinica Medica Augusto Murri, University of Bari, Bari, Italy
    Cell Mol Life Sci 65:1523-43. 2008
    ..This review presents the role of nuclear receptors in intestinal carcinogenesis and explores their influence in maintenance of intestinal epithelium architecture...
  65. ncbi Mutant androgen receptor detected in an advanced-stage prostatic carcinoma is activated by adrenal androgens and progesterone
    Z Culig
    Department of Urology, University of Innsbruck, Austria
    Mol Endocrinol 7:1541-50. 1993
    ..This pattern of ligand-dependent trans-activation may have significance in the process controlling the progression of prostatic carcinoma...
  66. ncbi Increased estrogen rather than decreased androgen action is associated with longer androgen receptor CAG repeats
    Ilpo T Huhtaniemi
    Department of Reproductive Biology, Imperial College London, Hammersmith Campus, Du Cane Road, London W12 0NN, United Kingdom
    J Clin Endocrinol Metab 94:277-84. 2009
    ..However, findings on its phenotypic effects are inconclusive...
  67. ncbi Androgen dependent development of a modified anal fin, gonopodium, as a model to understand the mechanism of secondary sexual character expression in vertebrates
    Yukiko Ogino
    Center for Animal Resources and Development CARD, Graduate School of Medical and Pharmaceutical Sciences, Kumamoto University, Honjo 2 2 1, Kumamoto 860 0811, Japan
    FEBS Lett 575:119-26. 2004
    ..Androgen-induced GP formation may provide insights into the expression mechanism regulating the specification of sexual features in vertebrates...
  68. ncbi Novel FXXFF and FXXMF motifs in androgen receptor cofactors mediate high affinity and specific interactions with the ligand-binding domain
    Dennis J van de Wijngaart
    Department of Urology, Josephine Nefkens Institute, Erasmus MC, P O Box 1738, 3000 DR Rotterdam, The Netherlands
    J Biol Chem 281:19407-16. 2006
    ..In conclusion, we have demonstrated strong interaction of FXXFF and FXXMF motifs to the AR coactivator binding groove, thereby mediating specific binding of a subgroup of cofactors to the AR LBD...
  69. ncbi The human prostate cancer cell line LNCaP bears functional membrane testosterone receptors that increase PSA secretion and modify actin cytoskeleton
    Maeilena Kampa
    Laboratories of, Experimental Endocrinology, University of Crete, School of Medicine, Heraklion, GR 71110, Greece
    FASEB J 16:1429-31. 2002
    ..Membrane sites differ immunologically for intracellular androgen receptors. The secretion of PSA after membrane testosterone receptor stimulation was inhibited after pretreatment with ..
  70. ncbi Cloning and characterization of an androgen receptor N-terminal-interacting protein with ubiquitin-protein ligase activity
    L K Beitel
    Lady Davis Institute for Medical Research, SMBD Jewish General Hospital, 3755 Cote St Catherine Road, Montreal, Quebec, Canada
    J Mol Endocrinol 29:41-60. 2002
    ..Thus, identification of a novel AR-interacting protein with ubiquitin ligase activity will stimulate further investigation into the role of ubiquitination and the ubiquitin-proteasome system in AR-mediated cellular functions...
  71. ncbi Cloning and characterization of human prostate coactivator ARA54, a novel protein that associates with the androgen receptor
    H Y Kang
    George Whipple Lab for Cancer Research, Departments of Pathology, Urology, and Radiation Oncology and the Cancer Center, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Biol Chem 274:8570-6. 1999
    ..Through our findings, we have identified and characterized a novel AR coactivator, ARA54, which may play an important role in the AR signaling pathway in human prostate...
  72. ncbi Structural and functional consequences of glutamine tract variation in the androgen receptor
    Grant Buchanan
    Dame Roma Mitchell Cancer Research Laboratories, Adelaide University Hanson Institute, SA, Australia
    Hum Mol Genet 13:1677-92. 2004
    ..That between 91 and 99% of AR alleles in different racial-ethnic groups encode a polyQ tract in the range of Q16-Q29 suggests that N/C interaction has been preserved as an essential component of androgen-induced AR signaling...
  73. ncbi Elevated E2F1 inhibits transcription of the androgen receptor in metastatic hormone-resistant prostate cancer
    Joanne N Davis
    Department of Urology, University of Michigan, Ann Arbor, Michigan 48109, USA
    Cancer Res 66:11897-906. 2006
    ..Taken together, these results show that elevated E2F1, through its ability to repress AR transcription, may contribute to the progression of hormone-independent prostate cancer...
  74. pmc Comparative analysis of the influence of the high-mobility group box 1 protein on DNA binding and transcriptional activation by the androgen, glucocorticoid, progesterone and mineralocorticoid receptors
    Guy Verrijdt
    Division of Biochemistry, Faculty of Medicine, Catholic University of Leuven, Herestraat 49, B 3000 Leuven, Belgium
    Biochem J 361:97-103. 2002
    ..This 26-residue fragment is therefore essential for the influence of HMGB1 on DNA recognition by all steroid hormone receptors that were tested. However, it is dispensable for DNA binding by the androgen receptor...
  75. ncbi The androgen receptor recruits nuclear receptor CoRepressor (N-CoR) in the presence of mifepristone via its N and C termini revealing a novel molecular mechanism for androgen receptor antagonists
    Myles C Hodgson
    Division of Hematology Oncology and Endocrinology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 280:6511-9. 2005
    ..Taken together these data demonstrate that NCoR is a physiological regulator of the AR and reveal a new mechanism for AR antagonism that may be exploited for the development of more potent AR antagonists...
  76. pmc Crosstalk between the androgen receptor and beta-catenin in castrate-resistant prostate cancer
    Gang Wang
    Genome Sciences Centre, British Columbia Cancer Agency, Vancouver, British Columbia, Canada
    Cancer Res 68:9918-27. 2008
    ..These studies provide the first in vivo evidence to support aberrant activation of the AR through the Wnt/beta-catenin signaling pathway during progression of prostate cancer to the terminal castrate-resistant stage...
  77. ncbi Androgen receptors in thymic epithelium modulate thymus size and thymocyte development
    N J Olsen
    Department of Medicine, Division of Rheumatology, Vanderbilt University, Nashville, Tennessee 37232, USA
    Endocrinology 142:1278-83. 2001
    ..These data suggest that AR expressed by thymic epithelium are important modulators of thymocyte development...
  78. ncbi Androgen deprivation therapy for prostate cancer: current status and future prospects
    Hiroshi Miyamoto
    George Whipple Laboratory for Cancer Research, Departments of Pathology, Urology, and Radiation Oncology, and the Cancer Center, University of Rochester Medical Center, Rochester, New York, USA
    Prostate 61:332-53. 2004
    ..In order to improve overall survival, novel treatment strategies that prolong the androgen-dependent state and that are useful for androgen-independent disease based on specific molecular mechanisms need to be identified...
  79. pmc The role of androgen receptors in the masculinization of brain and behavior: what we've learned from the testicular feminization mutation
    Damian G Zuloaga
    Department of Psychology and Program in Neuroscience, 108 Giltner Hall, Michigan State University, East Lansing, Michigan 48824 1101, USA
    Horm Behav 53:613-26. 2008
    ..Traditionally, masculinization of the rodent brain is believed to depend on estrogen receptors (ERs) and not androgen receptors (ARs)...
  80. ncbi Androgen receptor levels and association with PIK3CA mutations and prognosis in breast cancer
    Ana M Gonzalez-Angulo
    Department of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 15:2472-8. 2009
    ..To examine the androgen receptor (AR) levels in breast cancer and to assess the impact of AR expression on patient outcomes...
  81. ncbi Localization of androgen and estrogen receptors in adult male mouse reproductive tract
    Qing Zhou
    Department of Veterinary Biosciences, University of Illinois, Urbana 61802, USA
    J Androl 23:870-81. 2002
    ..This study demonstrates that the reproductive tracts of male mice differ considerably from those of rats in expression of ARs and ERs and that caution is needed when extrapolating nuclear steroid receptor data across mammalian species...
  82. ncbi Ligand-dependent inhibition of beta-catenin/TCF signaling by androgen receptor
    Dennis R Chesire
    Brady Urological Institute Research Laboratories, The Johns Hopkins Medical Institutions, Baltimore, Maryland, MD 21287, USA
    Oncogene 21:8453-69. 2002
    ..Our analyses point to a reciprocal balance between AR and CRT function that may shape critical processes during normal prostate development and tumor progression...
  83. ncbi Prognostic markers in triple-negative breast cancer
    Emad A Rakha
    Department of Histopathology, Molecular Medical Sciences, University of Nottingham, Nottingham, United Kingdom
    Cancer 109:25-32. 2007
    ..Triple-negative breast cancer (estrogen receptor-negative, progesterone receptor-negative, and HER2-negative) is a high risk breast cancer that lacks the benefit of specific therapy that targets these proteins...
  84. ncbi Androgen receptor inhibits estrogen receptor-alpha activity and is prognostic in breast cancer
    Amelia A Peters
    Dame Roma Mitchell Cancer Research Laboratories, Discipline of Medicine, University of Adelaide, Hanson Institute, Adelaide, South Australia, Australia
    Cancer Res 69:6131-40. 2009
    ..We conclude that, by binding to a subset of EREs, the AR can prevent activation of target genes that mediate the stimulatory effects of 17beta-estradiol on breast cancer cells...
  85. ncbi Methylation and inactivation of estrogen, progesterone, and androgen receptors in prostate cancer
    Masahiro Sasaki
    Department of Urology, University of California, San Francisco 94121, USA
    J Natl Cancer Inst 94:384-90. 2002
    Prostate cancer development is initially steroid hormone dependent. Estrogen receptors (ERs), androgen receptors (ARs), and progesterone receptors (PRs) have been identified in normal and cancerous prostate tissues...
  86. ncbi Castration-resistant prostate cancer: locking up the molecular escape routes
    Ricardo M Attar
    Ortho Biotech Oncology R and D Centocor R and D, Radnor, PA 19087, USA
    Clin Cancer Res 15:3251-5. 2009
    ..We will summarize how these molecular hypotheses are being tested in the clinic by the latest therapeutic modalities...
  87. ncbi VCaP, a cell-based model system of human prostate cancer
    S Korenchuk
    Departments of Surgery and Internal Medicine, University of Michigan Comprehensive Cancer Center, 1500 E. Medical Center Drive-7303 CCGC, Ann Arbor, Michigan 48109-0946, USA
    In Vivo 15:163-8. 2001
    ..We believe that VCaP will be a useful addition to the existing models of prostate cancer, and enable more advanced study of the mechanisms of prostate cancer progression and metastasis...
  88. pmc Increased prostate cell proliferation and loss of cell differentiation in mice lacking prostate epithelial androgen receptor
    Chun Te Wu
    George Whipple Laboratory for Cancer Research, Departments of Pathology and Urology, University of Rochester, Rochester, NY 14620, USA
    Proc Natl Acad Sci U S A 104:12679-84. 2007
    ..These data support the hypothesis that epithelial AR controls prostate growth by suppressing epithelial proliferation in the mature gland...
  89. pmc Activated androgen receptor downregulates E-cadherin gene expression and promotes tumor metastasis
    Yan Nian Liu
    Institute of Medical Sciences, Tzu Chi University, Hualien, Taiwan
    Mol Cell Biol 28:7096-108. 2008
    ..These results suggest that, similarly to Snail and Twist, the activated AR can downregulate E-cadherin expression to promote the activation of epithelial-mesenchymal transition and tumor metastasis...
  90. ncbi Akt blocks ligand binding and protects against expanded polyglutamine androgen receptor toxicity
    Isabella Palazzolo
    Neurogenetics Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 35 Convent Drive, Bethesda, MD 20892, USA
    Hum Mol Genet 16:1593-603. 2007
    ..IGF-1 rescue of AR toxicity is diminished by alanine substitutions at the Akt consensus sites. These results highlight potential targets for therapeutic intervention in SBMA...
  91. ncbi Cytochrome c oxidase subunit Vb interacts with human androgen receptor: a potential mechanism for neurotoxicity in spinobulbar muscular atrophy
    A M Beauchemin
    Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, Montreal, Canada
    Brain Res Bull 56:285-97. 2001
    ..Interaction of COXVb and hAR, with subsequent sequestration of COXVb, may provide a mechanism for putative mitochondrial dysfunction in SBMA...
  92. pmc Regulation of androgen receptor and histone deacetylase 1 by Mdm2-mediated ubiquitylation
    Luke Gaughan
    Prostate Research Group, Northern Institute for Cancer Research Paul, O Gorman Building University of Newcastle Upon Tyne, Medical School Framlington Place, Newcastle upon Tyne NE2 4HH, UK
    Nucleic Acids Res 33:13-26. 2005
    ..In all, our data indicates a novel role for Mdm2 in regulating components of the AR transcriptosome...
  93. ncbi Caveolin-1 interacts with androgen receptor. A positive modulator of androgen receptor mediated transactivation
    M L Lu
    Division of Urologic Surgery, Department of Surgery, Renal Division, Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 276:13442-51. 2001
    ..Using a mammalian two-hybrid assay system, we determine that the NH(2) terminus region of caveolin-1 is responsible for the interaction with both the NH(2)-terminal domain and the ligand-binding domain of AR...
  94. pmc Nuclear receptor-induced chromosomal proximity and DNA breaks underlie specific translocations in cancer
    Chunru Lin
    Howard Hughes Medical Institute, University of California, San Diego School of Medicine, 9500 Gilman Drive, La Jolla, CA 92093 0648, USA
    Cell 139:1069-83. 2009
    ..Our data suggest that the confluence of two parallel pathways initiated by liganded nuclear receptor and genotoxic stress underlies nonrandom tumor translocations, which may function in many types of tumors and pathological processes...
  95. ncbi Ligand-independent androgen receptor activity is activation function-2-independent and resistant to antiandrogens in androgen refractory prostate cancer cells
    Scott M Dehm
    Department of Urology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    J Biol Chem 281:27882-93. 2006
    ..Our data thus demonstrate that the AR can inappropriately activate transcription in ADI PCa cells via mechanisms that are resistant to castration and AR antagonism, the two modes of androgen ablation used to treat advanced PCa...
  96. ncbi Androgen receptors in prostate cancer
    Z Culig
    Department of Urology, University of Innsbruck, Anichstrasse 35, A 6020 Innsbruck, Austria
    Endocr Relat Cancer 9:155-70. 2002
    ..New experimental therapies for prostate cancer are aimed to down-regulate AR expression and to overcome difficulties which occur because of the acquisition of agonistic properties of commonly used antiandrogens...
  97. ncbi Expression of progesterone receptor is a favorable prognostic marker in ovarian cancer
    Peng Lee
    Department of Pathology, New York University Medical Center, New York, NY 10003, USA
    Gynecol Oncol 96:671-7. 2005
    ..We therefore examined the pattern of expression of ERs, PRs, and ARs in a large number of samples of primary ovarian carcinoma by using a tissue microarray technique...
  98. ncbi Wnt signalling and prostate cancer
    G W Yardy
    Cancer and Immunogenetics Laboratory, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, UK
    Prostate Cancer Prostatic Dis 8:119-26. 2005
    ..Mutation or altered expression of Wnt genes in tumours may give prognostic information and treatments are being developed which target this pathway...
  99. ncbi Characterization of a novel androgen receptor mutation in a relapsed CWR22 prostate cancer xenograft and cell line
    Clifford G Tepper
    Division of Basic Sciences, University of California Davis Cancer Center and Department of Biological Chemistry, University of California, Davis School of Medicine, Sacramento, California 95817, USA
    Cancer Res 62:6606-14. 2002
    ..In summary, the CWR22Rv1 cell line displays both androgen-responsive and androgen-insensitive features due, at least in part, to a novel insertional mutation of the AR...
  100. ncbi JHDM2A, a JmjC-containing H3K9 demethylase, facilitates transcription activation by androgen receptor
    Kenichi Yamane
    Howard Hughes Medical Institute, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Cell 125:483-95. 2006
    ..Thus, our work identifies a histone demethylase and links its function to hormone-dependent transcriptional activation...
  101. pmc Modulation of androgen receptor activation function 2 by testosterone and dihydrotestosterone
    Emily B Askew
    Curriculum in Toxicology, Laboratories for Reproductive Biology, Lineberger Comprehensive Cancer Center, Department of Pediatrics, University of North Carolina, Chapel Hill 27599, USA
    J Biol Chem 282:25801-16. 2007
    ..We conclude that T is a weaker androgen than DHT because of less favorable T-dependent AR FXXLF and coactivator LXXLL motif interactions at AF2...

Research Grants74

  1. Role of the Y-Located TSPY Gene in Human Oncogenesis
    Yun Fai Chris Lau; Fiscal Year: 2013
    ..This project will shed important insights on how the Y-oncogene and X-tumor suppressor operate and how one can interfere or boost their actions respectively to treat prostate cancer. ..
  2. Vitamin D3, Interference with Androgen Signal and Inhibition of Prostate Cancer
    Bandana Chatterjee; Fiscal Year: 2013
    ..Information gleaned from our research may open up new strategies for prevention and clinical management of prostate cancer. ..
  3. Effects of Testosterone and Genetic Factors on Psychological and Motor Function i
    NICOLE RENEE TARTAGLIA; Fiscal Year: 2013
    ....
  4. Development of VN/14-1 and Related Analogs for Breast Cancer Therapy
    VINCENT COLLINS OFUKA NJAR; Fiscal Year: 2013
    ..The studies would also lead to the identification of biomarkers that would be useful in clinical trials. ..
  5. A Soft Topical Antiandrogenic Drug
    Wei Chu Xu; Fiscal Year: 2013
    ..The synthesis and discovery of an optimal locally active androgen antagonist to be applied to the skin to treat acne, alopecia, seborrhea (and hirsutism in women) are the subjects of this application. ..
  6. Runx Proteins and Sex Steroid Signaling in Bone
    Baruch Frenkel; Fiscal Year: 2009
    ..They will decipher cryptic mechanisms of action of existing SERMs, and support the rationale development of novel ones, based on their influence on Runx proteins. ..
  7. Androgen Receptor Pathway and Risk of Hepatic Fibrosis in Hepatitis C
    DONNA LORRAINE WHITE; Fiscal Year: 2013
    ....
  8. Genomic Enhancers at 8q24 and Prostate Cancer
    Gerhard A Coetzee; Fiscal Year: 2013
    ....
  9. The Mechanism of Cryptorchidism in LH Receptor Knockout Animals
    Zhenmin Lei; Fiscal Year: 2012
    ..The current proposal is focusing on determining androgen downstream target genes and subsequent signaling network during the process of inguinoscrotal testis descent, which may provide new insight into the causes of testis maldescent. ..
  10. Regulation of Rhox5 Transcriptional Elongation
    Marcy E Richardson; Fiscal Year: 2013
    ..The control of these two phenomena will be analyzed in the developmental and tissue-specific program that allows the expression of Rhox5 Pp in the mouse testis. ..
  11. Sex Steroids and Runx Signaling in Bone
    Baruch Frenkel; Fiscal Year: 2013
    ..They will decipher cryptic mechanisms of action of existing SERMs, and support the rationale development of novel ones, based on their influence on Runx proteins. ..
  12. The biology of blood-testis barrier dynamics
    C Yan Cheng; Fiscal Year: 2013
    ..It also offers new insight into: (i) developing novel approaches for male contraception, and (ii) the causes of unexplained male infertility. ..
  13. Steroid Regulation of Serotonin in Males
    CYNTHIA LOUISE BETHEA; Fiscal Year: 2013
    ..We hypothesize that serotonin neurons in male primates express estrogen receptor beta (ER[unreadable]) and androgen receptors (AR) and that the balance of activity at these receptors governs serotonin synthesis and neural function, ..
  14. Amoeboid Membrane Dynamics in Prostate Cancer
    Michael R Freeman; Fiscal Year: 2013
    ..DRF3 loss and the MAT may also be functionally important in other solid tumor systems. Consequently, these studies may provide information of more general significance to human cancer. ..
  15. Progesterone's Role in Pubertal Maturation in Normal and Hyperandrogenemic Adoles
    JESSICAH S P COLLINS; Fiscal Year: 2011
    ....
  16. Androgen Receptor-JunD Complex Inhibitors to Prevent Prostate Cancer Progression
    Hirak S Basu; Fiscal Year: 2012
    ..The most active agent, thus identified, can be further developed for preclinical and clinical testing to prevent progression of early-stage androgen-dependent PCa to CRPCa. ..
  17. IMMUNOLOGICAL ASPECTS OF HEMORRHAGE
    Irshad H Chaudry; Fiscal Year: 2010
    ....
  18. Timing of Exposure to Selenium and Isoflavones and Prostate Cancer Prevention
    EDWIN DOUGLAS LEPHART; Fiscal Year: 2010
    ..According to the NIH report "the effect of food constituents on molecular events in the prostate is unknown". Discovery of Se- and isoflavone-regulated genes will "identify biomarkers of the consumption of key dietary components". ..
  19. Testosterone Replacement Therapy in Advanced Chronic Kidney Disease
    Ralph Rabkin; Fiscal Year: 2009
    ..expression of key positive and negative regulators of muscle mass (IGF-1, myostatin and their receptors, androgen receptors, selected inflammatory cytokines) and key components of the ubiquitin-proteasome and calpain proteolytic ..
  20. Nemo-Like Kinase and the Pathogenesis of Spinal and Bulbar Muscular Atrophy
    TIFFANY WERLYNE TODD; Fiscal Year: 2013
    ....
  21. Regulation and Function of the Rhox5 Homeobox Gene
    MILES FROME WILKINSON; Fiscal Year: 2013
    ..In addition, Rhox5 is regulated by a novel transcriptional mechanism that may significantly add to our understanding of gene regulation in general. ..
  22. MAINTENANCE OF ORGAN FUNCTION FOLLOWING INJURY
    Irshad H Chaudry; Fiscal Year: 2012
    ..The funding will help to develop gender-specific therapy. Such therapy should prevent organ dysfunction after injury and reduce morbidity and mortality from subsequent sepsis in male and female trauma victims. ..
  23. Variations in Hormones During Menopause: Effects on Cognitive and Brain Aging
    Heather A Bimonte-Nelson; Fiscal Year: 2013
    ..This work will yield insight into cognitive effects of the menopause transition, variations in menopause type and HTs, and related mechanisms. ..
  24. Equol and Regulation of Prostate Growth
    Robert J Handa; Fiscal Year: 2011
    ..The long-term goal of this project is to define the mechanism by which equol acts to inhibit the pathological growth of the prostate gland ..
  25. Cognition in Rhesus Macaques in Relation to Age and Endocrine Status
    Henryk F Urbanski; Fiscal Year: 2013
    ..it is plausible that their age-related decline negatively impacts brain function, either directly through androgen receptors and/or indirectly through estrogen receptors...
  26. Regulatory architecture of the Androgen Receptor locus in development & evolution
    Philip L Reno; Fiscal Year: 2010
    ..Identifying the mechanisms by which AR expression is regulated may aid in the long-term diagnosis and treatment of these and other human diseases. ..
  27. Hormonal and Paracrine Regulation of Spermatogenesis
    Barry R Zirkin; Fiscal Year: 2010
    ..These biosensors will be designed to measure oxidized nucleosides, 8-oxodeoxyadenosine and 8-oxodeoxyguanosine, in the DNA of sperm from infertile men. ..
  28. Development of Nonhuman Primate Models for PSA Biology Studies
    JAMES NKAMBWE MUBIRU; Fiscal Year: 2013
    ..The aims of this proposal will be addressed using multidisciplinary approaches and through collaborative studies. ..
  29. Notch and Wnt signaling in protection by nandrolone against disuse atrophy
    Christopher Cardozo; Fiscal Year: 2012
    ..abstract_text> ..
  30. Metformin as a novel chemopreventive agent for prostate cancer
    Xin Li; Fiscal Year: 2013
    ..e. those with PIN or high-grade PIN). The novel combined cancer prevention therapy using metformin and mTOR inhibitors proposed in this study may display promising synergistic efficacy and will be translational to clinical application. ..
  31. PHYSIOLOGICAL DISSECTION OF THE SCN
    Rae Silver; Fiscal Year: 2010
    ..Preliminary studies indicate that GRP cells contain androgen receptors (AR), have a characteristic pattern of electrical activity, and identifiable morphological features and ..
  32. Neurobiology of Aggression Co-morbidity in Mouse Model of Idic15 Autism
    Matthew P Anderson; Fiscal Year: 2013
    ..Indeed it will be mostly androgen receptors and secondary testosterone surges that ultimately determine the activity of these brain regions and the ..
  33. CBP Bromodomain Antagonists Block Androgen Receptor in Prostate Cancer
    SYED S MUJTABA; Fiscal Year: 2010
    ..Given the central role of AR in PCa, these studies will have important implications for the prognosis and treatment of human tumors. ..
  34. Mechanisms for the Transition to Castrate Resistant Prostate Cancer
    Stephen R Plymate; Fiscal Year: 2013
    ..This proposal should also shed significant new light on mechanisms of progression to the lethal form of prostate. ..
  35. [F18]FMAU in Prostate Cancer
    Hossein Jadvar; Fiscal Year: 2010
    ....
  36. Loss of Filamin A Nuclear Localization in Prostate Cancer Progression
    Paramita M Ghosh; Fiscal Year: 2013
    ..We will determine in biopsies of the prostates of these patients the localization of Filamin A, FlnA phosphorylation, AR levels and Akt phosphorylation and determine whether they respond to androgen withdrawal therapy. ..
  37. Ack1: Activation and Consequences in Prostate Cancer
    HENRY SHELTON EARP; Fiscal Year: 2012
    ..This proposal has the potential to yield significant new information about how Ack1 promotes prostate cancer progression and may lead to novel ways of treating prostate cancer patients by targeting Ack1 tyrosine kinase with new drugs. ..
  38. Novel Strategy to Sensitize Prostate Cancer Cells to Radiation
    Marja T Nevalainen; Fiscal Year: 2013
    ....
  39. Role of chemokine Receptor CXCR7 in prostate cancer progression
    Bal L Lokeshwar; Fiscal Year: 2013
    ....
  40. Androgen Modulation of Neurodegeneration in Dopamine Neurons
    Rebecca L Cunningham; Fiscal Year: 2010
    ..Nopage numbering necessary. Not to exceed 3 publications;2 for predoctoral candidates.) E3 Check if Appendix is included PHS 416-1 (Rev. 10/05) Page 4 Form Page 4 ..
  41. Mechanism-based Classification and Targeting of Castration-Resistant Prostate Can
    PETER S contact NELSON; Fiscal Year: 2010
    ..The project also has the potential for further economic development by identifying new therapies for prostate cancer that will require advancement through the pharmaceutical industry. ..
  42. Axon, Testosterone and Mental Health during Adolescence
    Tomas Paus; Fiscal Year: 2013
    ....
  43. Modulation of Insulin Action by Testosterone in Men
    Nelly Pitteloud; Fiscal Year: 2010
    ..Therefore, if low T levels are shown to play a role in the pathogenesis of insulin resistance, T may well represent an important therapeutic modality for both preventing and treating the metabolic syndrome and type 2 diabetes in men. ..
  44. A Novel Synthetic Androgen Receptor Antagonist
    Zhongyun Dong; Fiscal Year: 2012
    ..The proposed research will establish that DL3 is a novel AR antagonist, will elucidate mechanisms by which DL3 interrupts AR signaling, and will determine therapeutic effects of DL3 against human prostate cancer cells in mice. ..
  45. Androgen targets in a simple behavioral system
    Cynthia L Jordan; Fiscal Year: 2013
    ..Data from our KD mouse model suggests that the disease begins in muscle. Treatments that target muscle may offer new hope for treating KD. ..
  46. Antitumor and chemopreventive activity of the Ecuadorian plant extract BIRM
    Bal L Lokeshwar; Fiscal Year: 2010
    ..This study should also provide a rationale for further development (if any), of this chemopreventive agent, i.e., clinical trials for orostate cancer and other malignant cancers. ..
  47. MSKCC Center for Molecular Imaging in Cancer
    STEVEN MARK LARSON; Fiscal Year: 2013
    ..In summary, we have shaped ICMIC-3 to closely adhere to the goals of PAR 09-157. ..
  48. MODELS OF SBMA MOTOR NEURON DEGENERATION
    Albert R La Spada; Fiscal Year: 2013
    ..These studies should provide insights into mechanisms of motor neuron disease, and could reveal targets for therapy development for SBMA and related motor neuron diseases. ..
  49. Delaying the Hormone Refractory Prostate Cancer by a Dietary Triterpene Lupeol
    MOHAMMAD SALEEM BHAT; Fiscal Year: 2010
    ..Successful completion of this proposal will establish the potential of Lupeol for the treatment of advanced prostate cancer. ..
  50. Role of Rho GDP dissociation inhibitors in androgen signaling in prostate cancer
    Allen C Gao; Fiscal Year: 2013
    ..VA FORM 10-1313-2 Page 2 of VA Form 10-1313 package JUN 1990(R) ..
  51. Mechanism of Estrogen-Induced Penile Dysfunction and Loss of Fertility
    HARI OM GOYAL; Fiscal Year: 2013
    ....
  52. Prostate Cancer: Targeting Androgen Receptor Signaling by Tetrandrine
    Hari K Koul; Fiscal Year: 2013
    ..Work proposed in this application, will contribute to development of a novel AR targeted therapy that may translate into an effective treatment regiment against prostate cancer and is therefore, highly relevant to Veteran health. ..
  53. Hormone-regulated Prostate Cancer Metastasis
    Michael L Lu; Fiscal Year: 2010
    ..Fully dissecting the molecular interactions along this signal pathway will fulfill the programmatic interest of understanding the basic biology between androgenic signals and prostate cancer metastatic progression. ..
  54. Microtubule dependent AR signaling predicts taxane sensitivity
    Paraskevi Giannakakou; Fiscal Year: 2013
    ..Molecular understanding of drug-resistance in the clinic will lead to the identification of therapeutic interventions to overcome it. ..
  55. Regulation of androgen receptor activity in prostate cancer cells in an aged mous
    STEPHANIE OLGA PEACOCK; Fiscal Year: 2013
    ..abstract_text> ..
  56. TGF-Beta and Androgen Signaling During Prostate Regression
    VERONICA R PLACENCIO; Fiscal Year: 2010
    ....
  57. Androgen Receptor Function in Prostate Cancer
    Richard G Pestell; Fiscal Year: 2013
    ....
  58. Regulation of Prostate Cancer Growth by PPARg Ligands
    LAMONICA VANETTE STEWART; Fiscal Year: 2010
    ..This information can then be used to design prostate cancer treatments involving PPARg ligands that can be tested initially in animal models and then further explored in clinical trials. ..
  59. TGF BETA RECEPTOR AND TUMOR PROGRESSION
    Luzhe Sun; Fiscal Year: 2012
    ..The knowledge gained from our research may lay the foundation for clinical trials with TGF? antagonist alone or in combination with a chemotherapeutic agent for the treatment of metastatic PCa. ..
  60. Regulation of androgen receptor function by H3K4 methylation in prostate cancer
    Qianben Wang; Fiscal Year: 2013
    ..The hypothesis that the data obtained from Aims 1 and 2 is relevant to human prostate cancer will be evaluated in CRPC and ADPC samples in this aim. ..
  61. Steroid Receptors and Transcriptional Control of Thymic Rebound
    Nancy R Manley; Fiscal Year: 2011
    ..The current proposal seeks to identify the cellular and molecular targets of androgen signaling in the postnatal thymus and during thymic rebound. ..
  62. New treatment for androgen sensitive and resistant prostate cancer
    Angela M Brodie; Fiscal Year: 2013
    ....
  63. STEROID HORMONES AND NEURONAL REGENERATION
    Kathryn Jones; Fiscal Year: 2001
    ..It is thought that testosterone mediates its actions through androgen receptors (AR) that are more prevalent in males than in females and are present at the surface of this particular ..
  64. Mechanisms of Testosterone Effects on Body Composition
    Shalendar Bhasin; Fiscal Year: 2007
    ..abstract_text> ..
  65. NF-kappaB Regulation by Androgen Receptor
    ALBERT BALDWIN JR; Fiscal Year: 2004
    ..The experiments have the potential to identify a new target in the regulatory cascade associated with androgen/AR signaling and to possibly identify a new target for treatment of androgen-independent cancer. ..
  66. ANDROGEN RECEPTOR REGULATION OF REPRODUCTIVE FUNCTION
    Elizabeth Wilson; Fiscal Year: 2002
    ..Studies outlined in this proposal will contribute to the understanding of molecular mechanisms of androgen regulated gene transcription. ..
  67. A DIAGNOSTIC TEST TO ASSESS RISK ASSOCIATED WITH ANDROGEN THERAPY
    Meharvan Singh; Fiscal Year: 2007
    ..preliminary data, to develop a diagnostic tool for the relative assessment of two pharmacologically distinct androgen receptors, each of which appear to mediate different effects on cell survival...
  68. ANDROGEN RECEPTORS IN CANCEROUS PROSTATIC TISSUE
    Donald Tindall; Fiscal Year: 1993
    ..Therefore, there is a need for a more reliable and specific means for studying androgen receptors in tumor tissue...
  69. ANDROGEN RECEPTOR REGULATION OF PROSTATE CANCER GROWTH
    Samir Taneja; Fiscal Year: 2002
    ....
  70. MOLECULAR DETERMINANTS OF ANDROGEN RECEPTOR FUNCTION
    Elizabeth M Wilson; Fiscal Year: 2011
    ..abstract_text> ..
  71. NEURAL ANDROGEN RECEPTORS FACILITATING COPULATION
    Ruth Wood; Fiscal Year: 1999
    ..We will determine the role of neonatal steroid exposure in the sexually dimorphic pattern of androgen receptors in MPOA...
  72. Efficacy and Mechanism of Novel Androgen Receptor Inhibitors
    Marc I Diamond; Fiscal Year: 2010
    ..These approaches will pinpoint the precise mechanisms of AR inhibition, will facilitate identification of intracellular targets, and will expand our knowledge of AR biology, facilitating new treatment strategies for PCa. ..
  73. HORMONAL REGULATION OF ANDROGEN RECEPTOR EXPRESSION
    Kerry Burnstein; Fiscal Year: 2002
    ..abstract_text> ..
  74. Androgen Receptor Expression in Developing Rat Forebrain
    Lydia Doncarlos; Fiscal Year: 2005
    ..Compelling accumulated data, however, have led us to hypothesize that androgen receptors are an integral component of the organizational effects of testosterone on the nervous system, and that ..