steroid receptors

Summary

Summary: Proteins found usually in the cytoplasm or nucleus that specifically bind steroid hormones and trigger changes influencing the behavior of cells. The steroid receptor-steroid hormone complex regulates the transcription of specific genes.

Top Publications

  1. ncbi Conversion of Bcl-2 from protector to killer by interaction with nuclear orphan receptor Nur77/TR3
    Bingzhen Lin
    The Burnham Institute, Cancer Center, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Cell 116:527-40. 2004
  2. pmc The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions
    J M Lehmann
    Department of Molecular Endocrinology, Glaxo Wellcome Research and Development, Research Triangle Park, North Carolina 27709, USA
    J Clin Invest 102:1016-23. 1998
  3. ncbi Nuclear receptor response elements mediate induction of intestinal MDR1 by rifampin
    A Geick
    Dr Margarete Fischer Bosch Institute of Clinical Pharmacology, Auerbachstrasse 112, D 70376 Stuttgart, Germany
    J Biol Chem 276:14581-7. 2001
  4. pmc Structural mechanism for sterol sensing and transport by OSBP-related proteins
    Young Jun Im
    Laboratory of Molecular Biology, National Institutes of Health, US Department of Health and Human Services, Bethesda, Maryland 20892, USA
    Nature 437:154-8. 2005
  5. pmc Minireview: the intersection of steroid receptors with molecular chaperones: observations and questions
    David F Smith
    Department of Biochemistry and Molecular Biology, Mayo Clinic Arizona, Scottsdale, Arizona 85259, USA
    Mol Endocrinol 22:2229-40. 2008
  6. pmc Control of steroid, heme, and carcinogen metabolism by nuclear pregnane X receptor and constitutive androstane receptor
    Wen Xie
    Center for Pharmacogenetics and Department of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Proc Natl Acad Sci U S A 100:4150-5. 2003
  7. ncbi Drosophila ultraspiracle modulates ecdysone receptor function via heterodimer formation
    T P Yao
    Howard Hughes Medical Institute, La Jolla, California
    Cell 71:63-72. 1992
  8. ncbi Transient receptor potential M3 channels are ionotropic steroid receptors in pancreatic beta cells
    Thomas F J Wagner
    Emmy Noether Research Group Toxikologie, Universitat des Saarlandes, D 66421 Homburg, Germany
    Nat Cell Biol 10:1421-30. 2008
  9. pmc Ecdysone [corrected] receptor isoforms play distinct roles in controlling molting and metamorphosis in the red flour beetle, Tribolium castaneum
    Anjiang Tan
    Department of Entomology, College of Agriculture, University of Kentucky, Lexington, KY 40546, USA
    Mol Cell Endocrinol 291:42-9. 2008
  10. ncbi Transcription factor and drug-metabolizing enzyme gene expression in lymphocytes from healthy human subjects
    Gerard Siest
    Equipe Institut National de la Santé et de la Recherche Médicale Génétique Cardiovasculaire CIC 9501, Faculte de Pharmacie, Universite Henri Poincare Nancy I, Nancy, France
    Drug Metab Dispos 36:182-9. 2008

Research Grants

  1. Physiology of Hypothalamic Neurosteroidal Progesterone
    Paul E Micevych; Fiscal Year: 2013
  2. Steroid Responsive Mechanisms in the Ear
    DENNIS ROYAL TRUNE; Fiscal Year: 2012
  3. Sex Steroid Hormone Regulation of Drug Reinforcement
    Diane Lebesgue; Fiscal Year: 2012
  4. Mechanisms of Sex Determination in Zebrafish
    JOHN HARVEY POSTLETHWAIT; Fiscal Year: 2013
  5. Gonadal Steroid Receptors and the Hypothalamo-Pituitary-Adrenal Axis
    Robert J Handa; Fiscal Year: 2013
  6. Genistein and Prostate Cancer
    Rajvir Dahiya; Fiscal Year: 2010
  7. Interacting Impact of Adrenal and Ovarian Aging on the CNS
    Henryk F Urbanski; Fiscal Year: 2011
  8. ROLE OF COREGULATORS IN STEROID HORMONE-REGULATED TRANSCRIPTION
    Michael R Stallcup; Fiscal Year: 2013
  9. Steroid Regulation of Serotonin in Males
    CYNTHIA LOUISE BETHEA; Fiscal Year: 2013
  10. Steroid-Based Contrast Agents for Magnetic Resonance Imaging of Endocrine Disease
    Thomas J Meade; Fiscal Year: 2013

Detail Information

Publications363 found, 100 shown here

  1. ncbi Conversion of Bcl-2 from protector to killer by interaction with nuclear orphan receptor Nur77/TR3
    Bingzhen Lin
    The Burnham Institute, Cancer Center, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Cell 116:527-40. 2004
    ....
  2. pmc The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions
    J M Lehmann
    Department of Molecular Endocrinology, Glaxo Wellcome Research and Development, Research Triangle Park, North Carolina 27709, USA
    J Clin Invest 102:1016-23. 1998
    ..These findings provide a molecular explanation for the ability of disparate chemicals to induce CYP3A4 levels and, furthermore, provide a basis for developing in vitro assays to aid in predicting whether drugs will interact in humans...
  3. ncbi Nuclear receptor response elements mediate induction of intestinal MDR1 by rifampin
    A Geick
    Dr Margarete Fischer Bosch Institute of Clinical Pharmacology, Auerbachstrasse 112, D 70376 Stuttgart, Germany
    J Biol Chem 276:14581-7. 2001
    ..Only one DR4 motif within this cluster is necessary for induction by rifampin. We conclude that induction of MDR1 is mediated by a DR4 motif in the upstream enhancer at about -8 kilobase pairs, to which PXR binds...
  4. pmc Structural mechanism for sterol sensing and transport by OSBP-related proteins
    Young Jun Im
    Laboratory of Molecular Biology, National Institutes of Health, US Department of Health and Human Services, Bethesda, Maryland 20892, USA
    Nature 437:154-8. 2005
    ..On the basis of these observations, we propose a model in which sterol and membrane binding promote reciprocal conformational changes that facilitate a sterol transfer and signalling cycle...
  5. pmc Minireview: the intersection of steroid receptors with molecular chaperones: observations and questions
    David F Smith
    Department of Biochemistry and Molecular Biology, Mayo Clinic Arizona, Scottsdale, Arizona 85259, USA
    Mol Endocrinol 22:2229-40. 2008
    An involvement of molecular chaperones in the action and well-being of steroid receptors was recognized early in the molecular era of hormone research. However, this has continued to be a topic of much enquiry and some confusion...
  6. pmc Control of steroid, heme, and carcinogen metabolism by nuclear pregnane X receptor and constitutive androstane receptor
    Wen Xie
    Center for Pharmacogenetics and Department of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Proc Natl Acad Sci U S A 100:4150-5. 2003
    ....
  7. ncbi Drosophila ultraspiracle modulates ecdysone receptor function via heterodimer formation
    T P Yao
    Howard Hughes Medical Institute, La Jolla, California
    Cell 71:63-72. 1992
    ....
  8. ncbi Transient receptor potential M3 channels are ionotropic steroid receptors in pancreatic beta cells
    Thomas F J Wagner
    Emmy Noether Research Group Toxikologie, Universitat des Saarlandes, D 66421 Homburg, Germany
    Nat Cell Biol 10:1421-30. 2008
    ..Our results establish that TRPM3 is an essential component of an ionotropic steroid receptor enabling unanticipated crosstalk between steroidal and insulin-signalling endocrine systems...
  9. pmc Ecdysone [corrected] receptor isoforms play distinct roles in controlling molting and metamorphosis in the red flour beetle, Tribolium castaneum
    Anjiang Tan
    Department of Entomology, College of Agriculture, University of Kentucky, Lexington, KY 40546, USA
    Mol Cell Endocrinol 291:42-9. 2008
    ..These data suggest that the EcR but not USP isoforms play distinct roles during the larval-pupal metamorphosis and EcRA plays a dominant role in transduction of ecdysteroid response in T. castaneum...
  10. ncbi Transcription factor and drug-metabolizing enzyme gene expression in lymphocytes from healthy human subjects
    Gerard Siest
    Equipe Institut National de la Santé et de la Recherche Médicale Génétique Cardiovasculaire CIC 9501, Faculte de Pharmacie, Universite Henri Poincare Nancy I, Nancy, France
    Drug Metab Dispos 36:182-9. 2008
    ..The expression of these genes in lymphocytes could be a useful tool for further studying the physiological and pathological variations of DME and TF related to environment, to drug intake, and to cardiovascular metabolic cycles...
  11. pmc An essential role for nuclear receptors SXR/PXR in detoxification of cholestatic bile acids
    W Xie
    Howard Hughes Medical Institute, Gene Expression Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 98:3375-80. 2001
    ..Therefore, we establish SXR and PXR as bile acid receptors and a role for the xenobiotic response in the detoxification of bile acids...
  12. ncbi Ovarian steroid receptors and their role in ovarian function
    Ann E Drummond
    Prince Henry s Institute of Medical Research, Monash University, PO Box 5152, VIC 3168, Clayton, Australia
    Mol Cell Endocrinol 191:27-33. 2002
    ..Future studies will focus on the regulation of somatic cell differentiation, assigning roles to individual ERs and establishing definitive targets of oestrogen action in the ovary...
  13. pmc Methylation at lysine 4 of histone H3 in ecdysone-dependent development of Drosophila
    Yurii Sedkov
    Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Nature 426:78-83. 2003
    ..We propose that TRR functions as a coactivator of EcR by altering the chromatin structure at ecdysone-responsive promoters...
  14. ncbi Epigenetic regulation of nuclear steroid receptors
    Jennifer E Leader
    Kimmel Cancer Center, Department of Cancer Biology, Thomas Jefferson University, 233 South 10th Street, Philadelphia, PA 19107, USA
    Biochem Pharmacol 72:1589-96. 2006
    ..This review focuses on the regulation of the NR estrogen receptor (ERalpha), androgen receptor (AR) and peroxisome proliferator activated receptor-gamma (PPARgamma), given their role in tumor onset and progression...
  15. pmc GRIP1, a novel mouse protein that serves as a transcriptional coactivator in yeast for the hormone binding domains of steroid receptors
    H Hong
    Department of Pathology, University of Southern California, Los Angeles, 90033, USA
    Proc Natl Acad Sci U S A 93:4948-52. 1996
    ..Thus, in yeast, GRIP1 can serve as a coactivator, potentiating the transactivation functions in steroid receptor HBDs, possibly by acting as a bridge between HBDs of the receptors and the basal transcription machinery...
  16. pmc A novel pregnane X receptor-mediated and sterol regulatory element-binding protein-independent lipogenic pathway
    Jie Zhou
    Center for Pharmacogenetics and Department of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, PA 15213, USA
    J Biol Chem 281:15013-20. 2006
    ..The cross-regulation of CD36 by PXR and PPARgamma suggests that this fatty acid transporter may function as a common target of orphan nuclear receptors in their regulation of lipid homeostasis...
  17. ncbi Immunohistochemical analysis of steroid receptors in ovaries of postmenopausal women--effects of aging and hormone status
    A Brodowska
    Department of Reproduction and Gynecology, Pomeranian Medical University, Szczecin, Poland
    Histol Histopathol 25:1009-16. 2010
    ..The significant correlation of decreasing expression of ER-alpha in normal ovarian tissue and decreasing concentrations of T, A and DHEAS in serum were found, as well as increasing serum concentrations of FSH and LH...
  18. ncbi The Drosophila seven-up gene, a member of the steroid receptor gene superfamily, controls photoreceptor cell fates
    M Mlodzik
    Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California, Berkeley 94720
    Cell 60:211-24. 1990
    ..Molecular analysis of svp reveals that it is a member of the steroid receptor gene superfamily and is likely to be a Drosophila homolog of the human transcription factor COUP...
  19. ncbi Molecular cloning of complementary DNA encoding the avian receptor for vitamin D
    D P McDonnell
    Science 235:1214-7. 1987
    ..a highly conserved cysteine-rich region that displayed homology with a domain characteristic of other steroid receptors and with the gag-erbA oncogene product of avian erythroblastosis virus...
  20. ncbi Modulation of nuclear steroid receptors by ursodeoxycholic acid inhibits TGF-beta1-induced E2F-1/p53-mediated apoptosis of rat hepatocytes
    Susana Sola
    Centro de Patogenese Molecular, Faculty of Pharmacy, University of Lisbon, Lisbon 1600 083, Portugal
    Biochemistry 43:8429-38. 2004
    ..01). Notably, pretreatment with UDCA resulted in a significant upregulation of nuclear steroid receptors (p < 0...
  21. ncbi Sex-steroid hormones and EGF signalling in breast and prostate cancer cells: targeting the association of Src with steroid receptors
    Ferdinando Auricchio
    Dipartimento di Patologia Generale, II Universita di Napoli, Via L De Crecchio, 7, 80138 Naples, Italy
    Steroids 73:880-4. 2008
    ..The peptide action is restricted to cells expressing the steroid receptors and to signals mediated by these receptors...
  22. ncbi Role of nuclear steroid receptors in apoptosis
    Joana D Amaral
    Research Institute for Medicines and Pharmaceutical Sciences, Faculty of Pharmacy, University of Lisbon, Av Prof Gama Pinto, 1649 003 Lisbon, Portugal
    Curr Med Chem 16:3886-902. 2009
    Nuclear steroid receptors (NSR) are ligand-activated transcription factors that play a key role in a variety of vital physiological phenomena including developmental or endocrine signaling, reproduction, and homeostasis...
  23. ncbi Cellular mechanisms of dendrite pruning in Drosophila: insights from in vivo time-lapse of remodeling dendritic arborizing sensory neurons
    Darren W Williams
    Department of Biology, University of Washington, Seattle, WA 98195, USA
    Development 132:3631-42. 2005
    ..Finally, we find that phagocytic blood cells not only engulf neuronal debris but also attack and sever intact branches that show signs of destabilization...
  24. ncbi COUP-TF orphan nuclear receptors in development and differentiation
    F A Pereira
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Cell Mol Life Sci 57:1388-98. 2000
    ..This defines the COUP-TFs as important factors in regulation of development and differentiation in multiple organisms...
  25. pmc Involvement of the histone deacetylase SIRT1 in chicken ovalbumin upstream promoter transcription factor (COUP-TF)-interacting protein 2-mediated transcriptional repression
    Thanaset Senawong
    Laboratory of Molecular Pharmacology, Department of Pharmaceutical Sciences, College of Pharmacy, Environmental Health Sciences Center, Oregon State University, Corvallis, Oregon 97331, USA
    J Biol Chem 278:43041-50. 2003
    ..These findings implicate SIRT1 as a histone H3/H4 deacetylase in mammalian cells and in transcriptional repression mediated by CTIP2...
  26. pmc The oxysterol binding protein Kes1p regulates Golgi apparatus phosphatidylinositol-4-phosphate function
    Gregory D Fairn
    Department of Pediatrics, Dalhousie University, Halifax, NS, Canada B3H 4H7
    Proc Natl Acad Sci U S A 104:15352-7. 2007
    ..Kes1p affects both the availability and level of Golgi apparatus PI-4P. A set of potential PI-4P-responsive proteins that include the Rab GTPase Ypt31p and its GTP exchange factor are described...
  27. ncbi Nuclear receptors and lipid physiology: opening the X-files
    A Chawla
    Howard Hughes Medical Institute, Gene Expression Laboratory, The Salk Institute for Biological Studies, Post Office Box 85800, San Diego, CA 92186 5800, USA
    Science 294:1866-70. 2001
    ....
  28. pmc Nonvesicular sterol movement from plasma membrane to ER requires oxysterol-binding protein-related proteins and phosphoinositides
    Sumana Raychaudhuri
    Laboratory of Cell Biochemistry and Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, United States Department of Health and Human Services, Bethesda, MD 20892, USA
    J Cell Biol 173:107-19. 2006
    ..Our findings argue that ORPs move sterols among cellular compartments and that sterol transport and intracellular distribution are regulated by PIPs...
  29. ncbi COUP transcription factor is a member of the steroid receptor superfamily
    L h Wang
    Department of Cell Biology, Baylor College of Medicine, Houston, Texas 77030
    Nature 340:163-6. 1989
    ..We conclude that this superfamily of gene regulators contains proteins which bind and activate distal promoter elements of eukaryotic genes...
  30. ncbi A novel pathway for vitamin A signaling mediated by RXR heterodimerization with NGFI-B and NURR1
    T Perlmann
    Department of Cell and Molecular Biology, Karolinska Institute, Stockholm, Sweden
    Genes Dev 9:769-82. 1995
    ..Because expression of both NGFI-B and NURR1 is rapidly induced by various growth factors, these findings also suggest a novel mechanism for convergence between vitamin A or retinoid and growth factor signaling pathways...
  31. pmc Human pregnane X receptor antagonists and agonists define molecular requirements for different binding sites
    Sean Ekins
    ACT LLC, 601 Runnymede Avenue, Jenkintown, PA 19046, USA
    Mol Pharmacol 72:592-603. 2007
    ..These observations bear significant implications for future discovery of molecules that are more selective and potent antagonists...
  32. ncbi The RXR heterodimers and orphan receptors
    D J Mangelsdorf
    Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas 75235 9050, USA
    Cell 83:841-50. 1995
  33. pmc Functional redundancy of the Nur77 and Nor-1 orphan steroid receptors in T-cell apoptosis
    L E Cheng
    Department of Molecular and Cell Biology, University of California at Berkeley, 94720 3200, USA
    EMBO J 16:1865-75. 1997
    ..Constitutive expression of Nur77 in gld/gld mice rescues the lymphoproliferative phenotype of the FasL mutant mice. Thus, Nor-1 and Nur77 demonstrate functional redundancy in an apparently Fas-independent apoptosis...
  34. ncbi Cytosporone B is an agonist for nuclear orphan receptor Nur77
    Yanyan Zhan
    Key Laboratory of the Ministry of Education for Cell Biology and Tumor Cell Engineering, School of Life Sciences, Xiamen University, 422 South Siming Road, Xiamen, Fujian 361005, China
    Nat Chem Biol 4:548-56. 2008
    ..Thus, Csn-B may represent a promising therapeutic drug for cancers and hypoglycemia, and it may also be useful as a reagent to increase understanding of Nur77 biological function...
  35. ncbi Sequence and characterization of a coactivator for the steroid hormone receptor superfamily
    S A Onate
    Department of Cell Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Science 270:1354-7. 1995
    ..Because the protein stimulated transactivation of all the steroid receptors tested, it has been termed steroid receptor coactivator-1 (SRC-1)...
  36. ncbi Vitamin D receptor as an intestinal bile acid sensor
    Makoto Makishima
    Howard Hughes Medical Institute, Department of Pharmacology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9050, USA
    Science 296:1313-6. 2002
    ..These studies offer a mechanism that may explain the proposed protective effects of vitamin D and its receptor against colon cancer...
  37. ncbi PXR (NR1I2): splice variants in human tissues, including brain, and identification of neurosteroids and nicotine as PXR activators
    Vishal Lamba
    Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Toxicol Appl Pharmacol 199:251-65. 2004
    ..Moreover, the identification of PXR in many human tissues, such as brain, and activation by tissue specific ligands (such as neurosteroids) suggests additional biological roles for this receptor in these tissues...
  38. ncbi Post-transcriptional regulation of human pregnane X receptor by micro-RNA affects the expression of cytochrome P450 3A4
    Shingo Takagi
    Drug Metabolism and Toxicology, Division of Pharmaceutical Sciences, Graduate School of Medical Science, Kanazawa University, Kakuma machi, Kanazawa 920 1192, Japan
    J Biol Chem 283:9674-80. 2008
    ..This study will provide new insight into the unsolved mechanism of the large interindividual variability of CYP3A4 expression...
  39. ncbi The dietary isothiocyanate sulforaphane is an antagonist of the human steroid and xenobiotic nuclear receptor
    Changcheng Zhou
    Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA 98195, USA
    Mol Pharmacol 71:220-9. 2007
    ..g., lack of efficacy), which are a major public health problem, this discovery could lead to the development of important new therapeutic and dietary approaches to reduce the frequency of undesirable inducer-drug interactions...
  40. ncbi Novel single nucleotide polymorphisms in the promoter and intron 1 of human pregnane X receptor/NR1I2 and their association with CYP3A4 expression
    Jatinder Lamba
    Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Drug Metab Dispos 36:169-81. 2008
    ....
  41. pmc Oxysterol-binding-protein (OSBP)-related protein 4 binds 25-hydroxycholesterol and interacts with vimentin intermediate filaments
    Cheng Wang
    Atlantic Research Center, Department of Pediatrics, Dalhousie University, Halifax, Nova Scotia B3H 4H7, Canada
    Biochem J 361:461-72. 2002
    ..These studies elucidate a hitherto unknown relationship between OSBPs and the intermediate filament network that influences cholesterol transport...
  42. ncbi Dual roles of Nur77 in selective regulation of apoptosis and cell cycle by TPA and ATRA in gastric cancer cells
    Qiao Wu
    Key Laboratory of the Ministry of Education for Cell Biology, and Tumor Cell Engineering, School of Life Sciences, Xiamen University, Xiamen 361005, Fujian Province, China
    Carcinogenesis 23:1583-92. 2002
    ..Taken together, the data revealed the dual functioning mechanisms of Nur77 in gastric cancer cells in response to TPA and ATRA...
  43. ncbi Evaluation of steroid receptors, coregulators, and molecules associated with uterine receptivity in secretory endometria from untreated women with polycystic ovary syndrome
    Susana Quezada
    Institute of Maternal and Child Research, School of Medicine, San Borja Arriaran Clinical Hospital, University of Chile, Santiago, Chile
    Fertil Steril 85:1017-26. 2006
    To evaluate gene and protein expression of steroid receptors, nuclear receptor coregulators, and uterine receptivity markers in midsecretory phase endometria from untreated women with polycystic ovary syndrome (PCOS).
  44. pmc Cloning and characterization of a specific coactivator, ARA70, for the androgen receptor in human prostate cells
    S Yeh
    Department of Medicine and University of Wisconsin Comprehensive Cancer Center, University of Wisconsin, Madison 53792, USA
    Proc Natl Acad Sci U S A 93:5517-21. 1996
    ..Our data further indicated that ARA70 Will only slightly induce the transcriptional activity of other steroid receptors such as estrogen receptor, glucocorticoid receptor, and progesterone receptor in DU145 cells...
  45. pmc Modelling the interaction of steroid receptors with endocrine disrupting chemicals
    Pasqualina D'Ursi
    Department of Biomedical Sciences and Technologies, University of Milan, Segrate, Milan, 20090, Italy
    BMC Bioinformatics 6:S10. 2005
    ..There are several experimental evidences that they bind and activate human steroid receptors. However, despite the growing concern about the toxicological activity of endocrine disrupters, molecular ..
  46. ncbi Dehydroepiandrosterone sulfotransferase is a target for transcriptional induction by the vitamin D receptor
    Ibtissam Echchgadda
    Department of Molecular Medicine IBT University of Texas Health Science Center at San Antonio, San Antonio, Texas 78245, USA
    Mol Pharmacol 65:720-9. 2004
    ....
  47. ncbi RNR-1, a nuclear receptor in the NGFI-B/Nur77 family that is rapidly induced in regenerating liver
    L M Scearce
    Department of Genetics, Howard Hughes Medical Institute, University of Pennsylvania School of Medicine, Philadelphia 19104 6145
    J Biol Chem 268:8855-61. 1993
    ..As both the RNR-1 and r-NGFI/m-nur77 genes are induced during liver regeneration, it is very possible that RNR-1 acts concomitantly with r-NGFI/m-Nur77 in regulating the expression of delayed-early genes during liver regeneration...
  48. ncbi Transcriptional regulation of CYP2C9 gene. Role of glucocorticoid receptor and constitutive androstane receptor
    Sabine Gerbal-Chaloin
    INSERM U128, IFR24, Campus CNRS, 1919 Route de Mende, 34293 Montpellier, France
    J Biol Chem 277:209-17. 2002
    ..CYP2C9 appears therefore to be a primary glucocorticoid-responsive gene, which in addition, may be induced by xenobiotics through CAR/pregnane X receptor activation...
  49. ncbi Pregnane X receptor is essential for normal progression of liver regeneration
    Guoli Dai
    Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, KS 66160, USA
    Hepatology 47:1277-87. 2008
    ..Lack of PXR inhibited the second phase of liver growth, leading to 17% less liver mass at the anticipated end point of liver regeneration (day 10)...
  50. pmc Molecular chaperones function as steroid receptor nuclear mobility factors
    Cem Elbi
    Laboratory of Receptor Biology and Gene Expression, Building 41, Room B602, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 5055, USA
    Proc Natl Acad Sci U S A 101:2876-81. 2004
    ..Thus, our results provide a description of soluble nuclear mobility factors and furthermore demonstrate a previously unrecognized role for molecular chaperones in the regulation of steroid receptor function within the nucleus...
  51. ncbi Ecdysone receptor expression in the CNS correlates with stage-specific responses to ecdysteroids during Drosophila and Manduca development
    J W Truman
    Department of Zoology, University of Washington, Seattle 98195
    Development 120:219-34. 1994
    ..The heterogeneity of EcR expression at the start of metamorphosis presumably reflects the diverse origins and requirements of the neurons that nevertheless are all exposed to a common hormonal signal...
  52. pmc Coordinated lipid transfer between the endoplasmic reticulum and the Golgi complex requires the VAP proteins and is essential for Golgi-mediated transport
    Diego Peretti
    The Molecular Cell Biology Department, Weizmann Institute of Science, Rehovot 76100, Israel
    Mol Biol Cell 19:3871-84. 2008
    ..We propose that Nir2, OSBP, and CERT function coordinately at the ER-Golgi membrane contact sites, thereby affecting the lipid composition of the Golgi membranes and consequently their structural and functional identities...
  53. ncbi The steroid hormone 20-hydroxyecdysone enhances neurite growth of Drosophila mushroom body neurons isolated during metamorphosis
    R Kraft
    Arizona Research Laboratories, Division of Neurobiology, University of Arizona, Tucson, Arizona 85721 0077, USA
    J Neurosci 18:8886-99. 1998
    ..These results implicate 20E in enhancing axonal outgrowth of Kenyon cells to support MB remodeling during metamorphosis...
  54. pmc SXR, a novel steroid and xenobiotic-sensing nuclear receptor
    B Blumberg
    Gene Expression Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Genes Dev 12:3195-205. 1998
    ..These results strongly support the steroid sensor hypothesis and suggest that broad specificity sensing receptors may represent a novel branch of the nuclear receptor superfamily...
  55. ncbi Hypermethylation can selectively silence multiple promoters of steroid receptors in cancers
    Masahiro Sasaki
    Department of Urology 112F, University of California San Francisco and Veterans Affairs Medical Center, 4150 Clement Street, San Francisco, CA 94121, USA
    Mol Cell Endocrinol 202:201-7. 2003
    ..and differential splicing of 5' upstream exons are often found in various nuclear receptor genes including steroid receptors. Three promoters control the expression of human estrogen receptor alpha (ERalpha) isoforms: ERalpha-A, ..
  56. ncbi Dexamethasone induces pregnane X receptor and retinoid X receptor-alpha expression in human hepatocytes: synergistic increase of CYP3A4 induction by pregnane X receptor activators
    J M Pascussi
    Institut National de la Santé et de la Recherche Médicale U128, Institut Federatif de Recherche 24, Centre National de la Recherche Scientifique, Montpellier, France
    Mol Pharmacol 58:361-72. 2000
    ..These results reveal the existence of functional cross talk between the GR and PXR, and may explain some controversial aspects of the role of the GR in CYP3A4 induction...
  57. pmc The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity
    J L Staudinger
    Department of Molecular Endocrinology, GlaxoSmithKline, Research Triangle Park, NC 27709, USA
    Proc Natl Acad Sci U S A 98:3369-74. 2001
    ..These findings suggest that PXR agonists may prove useful in the treatment of human cholestatic liver disease...
  58. ncbi Nerve growth factor induces a gene homologous to the glucocorticoid receptor gene
    J Milbrandt
    Department of Pathology, Washington University School of Medicine, St Louis, Missouri 63110
    Neuron 1:183-8. 1988
    ..NGFI-B, as a possible ligand-dependent transcriptional activator induced by NGF, may play a role in initiating NGF-induced differentiation...
  59. ncbi Protein kinase D1 phosphorylates HDAC7 and induces its nuclear export after T-cell receptor activation
    Maribel Parra
    Gladstone Institute of Virology and Immunology, University of California, San Francisco, California 94158, USA
    J Biol Chem 280:13762-70. 2005
    ..In a mouse model of negative selection, PKD1 was activated during thymocyte activation. These observations indicate that PKD1 regulates the expression of Nur77 during thymocyte activation at least in part by phosphorylating HDAC7...
  60. ncbi Unimpaired thymic and peripheral T cell death in mice lacking the nuclear receptor NGFI-B (Nur77)
    S L Lee
    Department of Pathology, Washington University School of Medicine, St Louis, MO 63110, USA
    Science 269:532-5. 1995
    ..Anti-CD3-induced death was normal in CD4+ peripheral T cells, in which death is mediated predominantly by the Fas signaling pathway. Thus, no unique requirement for NGFI-B is observed for thymic or peripheral T cell death...
  61. ncbi Transcription activation by the ecdysone receptor (EcR/USP): identification of activation functions
    Xiao Hu
    Department of Biology, Jordan Hall, 1001 East Third Street, Bloomington, Indiana 47405, USA
    Mol Endocrinol 17:716-31. 2003
    ..Thus, in the setting tested, the ecdysone receptor can activate transcription using the AF1 regions of EcR-B1 or -B2 and the AF2 region of EcR. USP acts as an allosteric effector for EcR, but does not contribute any intrinsic function...
  62. ncbi Glucocorticoid-mediated induction of CYP3A4 is decreased by disruption of a protein: DNA interaction distinct from the pregnane X receptor response element
    Wafaa El-Sankary
    Molecular Toxicology Group, School of Biomedical and Life Sciences, University of Surrey, Guildford, United Kingdom
    Drug Metab Dispos 30:1029-34. 2002
    ..Such data provides strong evidence that glucocorticoids induce CYP3A4 gene expression both through the established PXR-dependent pathway but also through a PXR-independent pathway...
  63. pmc Overlapping functions of the yeast oxysterol-binding protein homologues
    C T Beh
    Department of Molecular and Cell Biology, University of California, Berkeley, California 94720 3202, USA
    Genetics 157:1117-40. 2001
    ..Our findings indicated that OSH genes performed a multitude of nonessential roles defined by specific subsets of the genes and that most shared at least one essential role potentially linked to changes in sterol lipid levels...
  64. pmc Nuclear compartmentalization of N-CoR and its interactions with steroid receptors
    Yin Wu
    Department of Geriatric Medicine, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Mol Cell Biol 26:6633-55. 2006
    ..The focus formation may reflect the accumulation of SHR/coactivator complexes released from the transcriptionally active sites and thus be a mirror of transcriptionally active complex formation...
  65. ncbi The expression of CYP2B6, CYP2C9 and CYP3A4 genes: a tangle of networks of nuclear and steroid receptors
    J M Pascussi
    Institut National de la Santé et de la Recherche Médicale U128, IFR 24, Centre National de la Recherche Scientifique, 1919 Route de Mende, 34293 05, Montpellier, France
    Biochim Biophys Acta 1619:243-53. 2003
    ..X receptor (RXR, NR2B1), the pregnane X receptor (PXR, NR1I2), and the vitamin D receptor (VDR, NR1I1) and steroid receptors such as the glucocorticoid receptor (GR, NR3C1)...
  66. pmc Phosphorylation of histone deacetylase 7 by protein kinase D mediates T cell receptor-induced Nur77 expression and apoptosis
    Franck Dequiedt
    Cellular and Molecular Biology Unit, Faculty of Agronomy, B 5030 Gembloux, Belgium
    J Exp Med 201:793-804. 2005
    ..These findings indicate that PKD is likely to play a key role in the signaling pathways controlling negative selection...
  67. ncbi A role for the COUP-TF-related gene seven-up in the diversification of cardioblast identities in the dorsal vessel of Drosophila
    P C Lo
    Department of Biochemistry and Molecular Biology, Mount Sinai School of Medicine, 1 Gustave Levy Place, New York, NY 10029, USA
    Mech Dev 104:49-60. 2001
    ..We also describe the tinman cis sequences that mediate tinman repression by seven-up and examine whether Seven-up can bind these sequences to directly inhibit tinman...
  68. ncbi Time-dependent relevance of steroid receptors in breast cancer
    D Coradini
    Unità Operativa Determinanti Biomolecolari nella Prognosi e Terapia, Milan, Italy
    J Clin Oncol 18:2702-9. 2000
    ....
  69. pmc The steroid and xenobiotic receptor (SXR), beyond xenobiotic metabolism
    Changcheng Zhou
    Laboratory of Biochemical Genetics and Metabolism, The Rockefeller University, New York, New York, USA
    Nucl Recept Signal 7:e001. 2009
    ..The discovery and pharmacological development of new PXR modulators might represent an interesting and innovative therapeutic approach to combat various diseases...
  70. ncbi Destabilization of steroid receptors by heat shock protein 90-binding drugs: a ligand-independent approach to hormonal therapy of breast cancer
    R Bagatell
    Department of Pediatrics, Steele Memorial Children s Research Center, University of Arizona, Tucson, Arizona 85724, USA
    Clin Cancer Res 7:2076-84. 2001
    ....
  71. ncbi The pleckstrin homology domain of oxysterol-binding protein recognises a determinant specific to Golgi membranes
    T P Levine
    MRC Laboratory of Molecular Biology, Cambridge, UK
    Curr Biol 8:729-39. 1998
    ..It does, however, contain a pleckstrin homology (PH) domain, which in other proteins has been found to mediate regulated membrane binding, although in all previously studied examples the binding is to the plasma membrane...
  72. ncbi Explaining variability in tacrolimus pharmacokinetics to optimize early exposure in adult kidney transplant recipients
    Rogier R Press
    Department of Clinical Pharmacy and Toxicology, Leiden University Medical Center, Albinusdreef 2, Leiden, The Netherlands
    Ther Drug Monit 31:187-97. 2009
    ..5 times higher, fixed, starting dose compared with CYP3A5*3/*3 to reach the predefined target exposure early after transplantation...
  73. ncbi An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway
    S A Kliewer
    Department of Molecular Endocrinology, Glaxo Wellcome Research and Development, Research Triangle Park, North Carolina 27709, USA
    Cell 92:73-82. 1998
    ..Our results provide evidence for the existence of a novel steroid hormone signaling pathway with potential implications in the regulation of steroid hormone and sterol homeostasis...
  74. ncbi GST-Induced dimerization of DNA-binding domains alters characteristics of their interaction with DNA
    A Niedziela-Majka
    Biochemistry and Biotechnology, Division of Biochemistry, Wroclaw University of Technology, Wybrzeze Wyspianskiego 27, Wroclaw, 50 370, Poland
    Protein Expr Purif 14:208-20. 1998
    ..Furthermore, our results add to the recent findings which indicate the need for caution in interpreting the activities of GST fusion proteins...
  75. pmc Possible involvement of pregnane X receptor-enhanced CYP24 expression in drug-induced osteomalacia
    Jean Marc Pascussi
    INSERM 632, IFR122, Campus CNRS, Montpellier, France
    J Clin Invest 115:177-86. 2005
    ..These data suggest that xenobiotics and drugs can modulate CYP24 gene expression and alter vitamin D(3) hormonal activity and calcium homeostasis through the activation of PXR...
  76. ncbi Regulation of CYP2B6 in primary human hepatocytes by prototypical inducers
    Stephanie R Faucette
    Division of Drug Delivery and Disposition, School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7360, USA
    Drug Metab Dispos 32:348-58. 2004
    ..These results indicate that CYP2B6 is highly inducible by known CYP3A4 inducers and suggest that hPXR is a major determinant of CYP2B6-inducible expression for many, but not all, compounds evaluated in this study...
  77. ncbi Vascular endothelial growth factor-regulated gene expression in endothelial cells: KDR-mediated induction of Egr3 and the related nuclear receptors Nur77, Nurr1, and Nor1
    Dan Liu
    BHF Laboratories, Department of Medicine, University College London, London, UK
    Arterioscler Thromb Vasc Biol 23:2002-7. 2003
    ..The program of gene expression regulated by vascular endothelial growth factor (VEGF) remains poorly understood. The aim of this study was to identify VEGF-regulated genes in human umbilical vein endothelial cells...
  78. ncbi A novel distal enhancer module regulated by pregnane X receptor/constitutive androstane receptor is essential for the maximal induction of CYP2B6 gene expression
    Hongbing Wang
    Division of Drug Delivery and Disposition, School of Pharmacy, University of North Carolina, Chapel Hill 27599, USA
    J Biol Chem 278:14146-52. 2003
    ..These results show that a novel xenobiotic-responsive enhancer module in the distal region of the CYP2B6 promoter (CYP2B6-XREM) together with the PBREM mediates optimal drug-induced expression of CYP2B6...
  79. ncbi Cell-autonomous requirement of the USP/EcR-B ecdysone receptor for mushroom body neuronal remodeling in Drosophila
    T Lee
    Department of Biological Sciences, Stanford University, Stanford, CA 94305
    Neuron 28:807-18. 2000
    ..Surprisingly, most identified primary EcR/USP targets are dispensable for MB neuronal remodeling. Our study demonstrates cell-autonomous roles for EcR/USP in controlling neuronal remodeling, potentially through novel downstream targets...
  80. ncbi A steroid receptor coactivator, SRA, functions as an RNA and is present in an SRC-1 complex
    R B Lanz
    Department of Cell Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Cell 97:17-27. 1999
    ..We suggest that SRA may act to confer functional specificity upon multiprotein complexes recruited by liganded receptors during transcriptional activation...
  81. ncbi BRI1 is a critical component of a plasma-membrane receptor for plant steroids
    Z Y Wang
    Howard Hughes Medical Institute and Plant Biology Laboratory, The Salk Institute for Biological Studies, 10010 N. Torrey Pines Road, La Jolla, California 92037, USA
    Nature 410:380-3. 2001
    ....
  82. pmc The pregnane X receptor: from bench to bedside
    Xiaochao Ma
    National Cancer Institute, Laboratory of Metabolism, Center for Cancer Research, National Institutes of Health, Bethesda, MD 20892, USA
    Expert Opin Drug Metab Toxicol 4:895-908. 2008
    ..The pregnane X receptor (PXR; NR1I2), a member of the nuclear receptor superfamily, regulates the expression of metabolic enzymes and transporters involved in the response of mammals to their chemical environment...
  83. pmc Elucidating the 'Jekyll and Hyde' nature of PXR: the case for discovering antagonists or allosteric antagonists
    Arunima Biswas
    Albert Einstein Cancer Center, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Pharm Res 26:1807-15. 2009
    ..Based on this review it will be clear that antagonists of PXR and PXR-like pathways will have widespread utility in PXR biology and therapeutics...
  84. ncbi A comprehensive in vitro and in silico analysis of antibiotics that activate pregnane X receptor and induce CYP3A4 in liver and intestine
    Kazuto Yasuda
    Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Drug Metab Dispos 36:1689-97. 2008
    ..In summary, nafcillin, dicloxacillin, cephradine, tetracycline, sulfixoxazole, erythromycin, clindamycin, and griseofulvin exhibit a clear propensity to induce CYP3A4 and warrant further clinical investigation...
  85. ncbi Juvenile hormone counteracts the bHLH-PAS transcription factors MET and GCE to prevent caspase-dependent programmed cell death in Drosophila
    Ying Liu
    Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200032, China
    Development 136:2015-25. 2009
    ..For the first time, we demonstrate that JH counteracts MET and GCE to prevent caspase-dependent PCD in controlling fat body remodeling and larval-pupal metamorphosis in Drosophila...
  86. ncbi A pharmacophore for human pregnane X receptor ligands
    Sean Ekins
    Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Drop Code 0730, Indianapolis, IN 46285, USA
    Drug Metab Dispos 30:96-9. 2002
    ..Ultimately, this will aid in the selection of molecules with a lesser capacity to be potent PXR ligands and thus avoid induction of numerous drug-metabolizing enzymes and MDR1...
  87. ncbi The roles of nuclear receptors CAR and PXR in hepatic energy metabolism
    Yoshihiro Konno
    The Pharmacogenetics Section, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, North Carolina 27709, USA
    Drug Metab Pharmacokinet 23:8-13. 2008
    ..In addition, CAR modulates thyroid hormone activity by regulating type 1 deiodinase in the regenerating liver. Thus, CAR and PXR are now placed at the crossroad where both xenobiotics and endogenous stimuli co-regulate liver function...
  88. ncbi Apoptosis of T cells mediated by Ca2+-induced release of the transcription factor MEF2
    H D Youn
    Center for Cancer Research, Department of Biology, Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Science 286:790-3. 1999
    T cell receptor (TCR)-induced apoptosis of thymocytes is mediated by calcium-dependent expression of the steroid receptors Nur77 and Nor1...
  89. ncbi The Drosophila EcR gene encodes an ecdysone receptor, a new member of the steroid receptor superfamily
    M R Koelle
    Department of Biochemistry, Stanford University Medical Center, California 94305
    Cell 67:59-77. 1991
    ..As expected, EcR is nuclear and found in all ecdysone target tissues examined. Furthermore, the EcR gene is expressed at each developmental stage marked by a pulse of ecdysone...
  90. ncbi Natural protein variants of pregnane X receptor with altered transactivation activity toward CYP3A4
    E Hustert
    EPIDAUROS Biotechnologie AG, Bernried, Germany
    Drug Metab Dispos 29:1454-9. 2001
    ..Thus, these natural PXR protein variants may play a role in the observed interindividual variability of CYP3A4 expression and may be involved in rare, atypical responses to drugs or altered sensitivities to carcinogens...
  91. ncbi Mechanisms of receptor-mediated nuclear import and nuclear export
    Lucy F Pemberton
    Center for Cell Signaling, University of Virginia, Charlottesville, VA 22908, USA
    Traffic 6:187-98. 2005
    ..Understanding the molecular basis of nuclear transport may provide insight into human diseases by revealing how nucleocytoplasmic trafficking regulates protein activity...
  92. ncbi Genetic profiling defines the xenobiotic gene network controlled by the nuclear receptor pregnane X receptor
    John M Rosenfeld
    The Salk Institute for Biological Studies, La Jolla, California 90237, USA
    Mol Endocrinol 17:1268-82. 2003
    ..Moreover, comparative analysis of data from both genetic and pharmacological arrays reveals a core network that represents a genetic description of the xenobiotic response...
  93. ncbi Oxysterol binding proteins: in more than one place at one time?
    Vesa M Olkkonen
    Department of Molecular Medicine, National Public Health Institute, Helsinki, Finland
    Biochem Cell Biol 82:87-98. 2004
    ..Specifically, we suggest a model in which a general property of ORPs is to function at membrane contact sites, specialized zones of communication between two different organelles...
  94. ncbi Activation of Nur77 by selected 1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes induces apoptosis through nuclear pathways
    Sudhakar Chintharlapalli
    Department of Biochemistry and Biophysics, Texas A and M University, College Station, Texas 77843, USA
    J Biol Chem 280:24903-14. 2005
    ....
  95. ncbi Apis mellifera ultraspiracle: cDNA sequence and rapid up-regulation by juvenile hormone
    A R Barchuk
    Departamento de Genetica, Faculdade de Medicina de Ribeirao Preto, Universidade de Sao Paulo, Brazil
    Insect Mol Biol 13:459-67. 2004
    ..These characteristics and the rapid up-regulation by JH suggest that some of the USP functions in the honey bee may depend on ligand binding...
  96. ncbi The nuclear pregnane X receptor: a key regulator of xenobiotic metabolism
    Steven A Kliewer
    Nuclear Receptor Discovery Research, GlaxoSmithKline, Research Triangle Park, North Carolina 27709, USA
    Endocr Rev 23:687-702. 2002
    ..Thus, assays that detect PXR activity will be useful in developing safer prescription drugs...
  97. ncbi Dual role of orphan nuclear receptor pregnane X receptor in bilirubin detoxification in mice
    Simrat P S Saini
    Center for Pharmacogenetics, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Hepatology 41:497-505. 2005
    ..PXR is a potential therapeutic target for clinical treatment of jaundice. (HEPATOLOGY 2005;41:497-505.)...
  98. ncbi Extranuclear steroid receptors: nature and actions
    Stephen R Hammes
    Department of Medicine, Division of Endocrinology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8857, USA
    Endocr Rev 28:726-41. 2007
    ..and other signaling molecules in confined areas of the membrane, have led to a fuller understanding of how steroid receptors effect rapid actions...
  99. ncbi Genetic variants of PXR (NR1I2) and CAR (NR1I3) and their implications in drug metabolism and pharmacogenetics
    Jatinder Lamba
    Department of Pharmaceutical Sciences, Mail Stop 313, St Jude Children s Research Hospital, 332 N Lauderdale Street, Memphis, TN 38105, USA
    Curr Drug Metab 6:369-83. 2005
    ..Identification of PXR and CAR genetic variants and alternatively spliced mRNAs may ultimately allow predictions of interindividual differences in target gene induction and drug-drug interactions...
  100. ncbi Functional characterization of a novel polymorphism of pregnane X receptor, Q158K, in Chinese subjects
    Yun Ping Lim
    Institute of Basic Medical Sciences, Medical College, National Cheng Kung University, Tainan, Taiwan
    Pharmacogenet Genomics 15:337-41. 2005
    ..The SNP had less effect on promoter activity in response to clotrimazole or nifedipine...
  101. ncbi CYP3A induction by liver x receptor ligands in primary cultured rat and mouse hepatocytes is mediated by the pregnane X receptor
    Sarita D Shenoy
    Institute of Environmental Health Sciences, 2727 Second Avenue, Room 4000, Detroit, MI 48201, USA
    Drug Metab Dispos 32:66-71. 2004
    ..These results indicate that selected LXR ligands are capable of activating PXR, probably as a defensive measure to prevent the accumulation of these potentially toxic endogenous molecules...

Research Grants70

  1. Physiology of Hypothalamic Neurosteroidal Progesterone
    Paul E Micevych; Fiscal Year: 2013
    ..Since GnRH neurons that control the LH surge do not have steroid receptors, other neurons are required to transmit steroid information to them...
  2. Steroid Responsive Mechanisms in the Ear
    DENNIS ROYAL TRUNE; Fiscal Year: 2012
    ..Of particular interest are immune suppression of inflammatory cytokines and related transcription factors compared to the regulation of ion transport pathways that control fluid homeostasis. ..
  3. Sex Steroid Hormone Regulation of Drug Reinforcement
    Diane Lebesgue; Fiscal Year: 2012
    ..Mary Kritzer, a highly skilled neuroanatomist who has made seminal observations on the expression of sex steroid receptors in brain regions involved in motivated behaviors, and Dr...
  4. Mechanisms of Sex Determination in Zebrafish
    JOHN HARVEY POSTLETHWAIT; Fiscal Year: 2013
    ....
  5. Gonadal Steroid Receptors and the Hypothalamo-Pituitary-Adrenal Axis
    Robert J Handa; Fiscal Year: 2013
    ....
  6. Genistein and Prostate Cancer
    Rajvir Dahiya; Fiscal Year: 2010
    ....
  7. Interacting Impact of Adrenal and Ovarian Aging on the CNS
    Henryk F Urbanski; Fiscal Year: 2011
    ..The focus will be on genes encoding enzymes involved in the conversion of DHEA to estradiol, steroid receptors, and genes associated with key neurotransmitters systems and circadian clocks...
  8. ROLE OF COREGULATORS IN STEROID HORMONE-REGULATED TRANSCRIPTION
    Michael R Stallcup; Fiscal Year: 2013
    ..The new basic knowledge obtained in this project will identify new potential targets for therapeutic intervention in these diseases. ..
  9. Steroid Regulation of Serotonin in Males
    CYNTHIA LOUISE BETHEA; Fiscal Year: 2013
    ..A regulatory mechanism is proposed that could lead to a novel treatment in psychiatric illnesses with explosive rage and impulse disorders. ..
  10. Steroid-Based Contrast Agents for Magnetic Resonance Imaging of Endocrine Disease
    Thomas J Meade; Fiscal Year: 2013
    ..imaging (MRI) contrast agents to facilitate molecular characterization of the status and function of steroid receptors in hormone-dependent disease and development...
  11. Epigenetic regulation of liver transporters
    Frederick J Suchy; Fiscal Year: 2013
    ..These studies will provide insight into an unexplored area of hepatic biology and pathobiology, and suggest potential new targets for drug development. ..
  12. TARGETING G(alpha)q AND SRC-3 SIGNALING AS A NOVEL THERAPEUTIC APPROACH IN MELANO
    Vasiliki Poulaki; Fiscal Year: 2013
    ....
  13. RNA Modification Enzymes: Methyltransferase/psi-synthase
    Robert M Stroud; Fiscal Year: 2012
    ..The importance of synthase activity is underlined by disorders such as sideroplastic anemia. The RNA MTase is a potential new drug target for anti-HIV therapy. ..
  14. Mechanisms for the evolution of novel DNA specificity in a transcription factor f
    Joseph W Thornton; Fiscal Year: 2013
    ..that this diversity evolved via a sharp shift in DNA recognition that occurred between the ancestor of all steroid receptors (AncSR1) and the ancestor of the APGMRs (AncSR2)...
  15. Steroid-Dependent Changes in the Yorkie Interactome
    Alexey Veraksa; Fiscal Year: 2013
    ..In the second aim, we will use the diverse array of genetic tools in Drosophila to assess the role of individual YNI proteins (identified in the AP- MS experiments) in controlling Yki activity in developing tissues. ..
  16. Role of Phospho-Progesterone Receptors (PR) in Hormone Refractory Breast Cancer
    CAROL ANN LANGE; Fiscal Year: 2013
    ..Our studies on phospho- PR signaling will provide valuable insight into the coordinated regulation of PR and ER function by pathways that can be easily targeted for therapeutic intervention. ..
  17. Non-genomic actions of estrogen in breast cancer
    Ellis R Levin; Fiscal Year: 2013
    ..and progesterone receptors that dictates palmitoylation, resulting in membrane localization of the sex steroid receptors. We now propose to isolate and characterize the palmitoylacyltransferase (PAT) protein(s) that palmitoylate ..
  18. Steroid Receptor Coactivator-2 as a key hepatic tumor suppressor and circadian me
    Erin Stashi; Fiscal Year: 2013
    ....
  19. Nuclear cofactors in hormone signaling
    Hongwu Chen; Fiscal Year: 2012
    ..Understanding the process will provide novel insights to the underlying molecular mechanisms of steroid receptor function in female reproduction and breast cancers as well as other endocrine disorders. ..
  20. Loss of Filamin A Nuclear Localization in Prostate Cancer Progression
    Paramita M Ghosh; Fiscal Year: 2013
    ..We will determine in biopsies of the prostates of these patients the localization of Filamin A, FlnA phosphorylation, AR levels and Akt phosphorylation and determine whether they respond to androgen withdrawal therapy. ..
  21. Actions of Estrogen on Uterine Artery Endothelium
    DongBao Chen; Fiscal Year: 2010
    ..These studies are relevant to uncover the dilemma of the cardiovascular protective effects of estrogen. ..
  22. Genomic and Translational Approaches to Neuroendocrine Switching Events
    Michael G Rosenfeld; Fiscal Year: 2013
    ..Under the second Specific Aim, new strategies to investigate tumor translocation by sex steroid receptors, the connection between specific demethylases and septic shock will be explored, and a new strategy for ..
  23. MOLECULAR PROBES FOR STEROID RECEPTORS
    John A Katzenellenbogen; Fiscal Year: 2012
    ..1 Description, ..
  24. Developmental programming: influence of sex steroids and mechanisms
    Chandrasekhar Yallampalli; Fiscal Year: 2013
    ..Effects include changes in vascular steroid receptors, endothelial and smooth muscle (VSM) function, and vascular rennin angiotensin system (RAS)...
  25. STEROID ANTAGONISTS AND RESISTANCE IN BREAST CANCER
    Dean P Edwards; Fiscal Year: 2012
    ..and that an imbalance between rapid extra-nuclear signaling and nuclear transcriptional actions of steroid receptors may contribute to the etiology and progression of hormone-dependent cancers...
  26. TRAINING PROGRAM IN MOLECULAR ENDOCRINOLOGY
    David D Moore; Fiscal Year: 2012
    ..The proximity of two medical schools, Rice University and M.D. Anderson Cancer Center, and the presence of 60,000 professionals make this a unique environment in which to perform medical research. ..
  27. Deguelin in therapy of triple negative breast cancer
    Rajendra G Mehta; Fiscal Year: 2013
    ....
  28. Influence of Endocrine Disruptors on Reproductive Neuroendocrine Function
    JOSEPH RAYMOND KURIAN; Fiscal Year: 2013
    ....
  29. The Role of SRC-1 in Breast Cancer
    Jianming Xu; Fiscal Year: 2013
    ....
  30. Steroid Receptors and Transcriptional Control of Thymic Rebound
    Nancy R Manley; Fiscal Year: 2011
    ..The current proposal seeks to identify the cellular and molecular targets of androgen signaling in the postnatal thymus and during thymic rebound. ..
  31. PROGRAMMED CELL DEATH IN NORMAL AND MALIGNANT T CELLS
    Astar Winoto; Fiscal Year: 2013
    ..abstract_text> ..
  32. Organochlorine and Gene Expression of Sex Steroids in a Multigenerational Cohort
    Janet Rose Osuch; Fiscal Year: 2011
    ..number of genes controlling both the synthesis and breakdown of sex steroids, as well as pertinent steroid receptors, will be performed in the surviving parents and their sons, daughters, and grandchildren...
  33. Hormones and Tumor Initiating Cells in Human Breast Cancers
    CAROL ANN SARTORIUS; Fiscal Year: 2013
    ..Opposite are "basal" breast cancers (~15%), which are negative for steroid receptors, and are hormone- independent...
  34. Roles of SRC-3 in Development and Disease
    Jianming Xu; Fiscal Year: 2013
    ..The knowledge to be obtained from these proposed studies may suggest SRC3 as a cell lineage-specific and tumor stage-specific target for prostate cancer treatment. ..
  35. Mechanisms of Steroid Action in Brain
    MARC JEFFREY TETEL; Fiscal Year: 2013
    ..While it has been accepted that steroid receptors can be activated in a classical ligand-dependent fashion, there is mounting evidence that receptors can be ..
  36. Quantitative Dissection of Steroid Receptor Function
    David L Bain; Fiscal Year: 2013
    ..Our research indicates that a) different steroid receptors exhibit variable energetics of inter-site cooperativity when binding to an identical promoter;and b) the ..
  37. Molecular Analysis of Steroid Hormone Receptors with X-ray Crystallography
    Kendall W Nettles; Fiscal Year: 2010
    ..Here we propose to further develop our new technology for molecular analyses of steroid receptors, which we strongly believe will revolutionize the use of X-ray crystallography in both basic research and ..
  38. REPRODUCTIVE BIOLOGY: REGULATORY MECHANISMS
    BERT W O'MALLEY; Fiscal Year: 2013
    ..studies the mechanisms of action of molecules important for reproduction and particularly the function of steroid receptors and their associated coactivators and corepressors...
  39. Role of HDAC6 in a murine model of affective disorder and antidepressant action
    Olivier Berton; Fiscal Year: 2013
    ..comprise, for instance, the regulation of HSP90's chaperone activity, an important component of steroid receptors signaling...
  40. A Unique Natural Model for Studying the Mechanisms Underlying Social Behavior
    Donna L Maney; Fiscal Year: 2013
    ..Here, we will study these influences in an animal model with a natural polymorphism that provides a unique opportunity to characterize the processes underlying aggression and parenting. ..
  41. Novel Antitumor Agents
    Kuo Hsiung Lee; Fiscal Year: 2013
    ..mechanism(s) of action based on chemical profiling and effects on responsible pathways, including sex steroid receptors, cell cycle arrest, kinase inhibition, or signal transduction pathways...
  42. GPCR-mediated nongenomic steroid actions in control of alcohol-induced behavior
    EMILY PETRUCCELLI; Fiscal Year: 2013
    ..Due to the high functional and mechanistic conservation of steroid signaling and alcohol response behaviors, understanding these effects should provide novel insights into the future prevention and treatment of alcohol use disorders. ..
  43. GENE REGULATION BY STEROID RECEPTOR PROTEINS
    KEITH ROBERT YAMAMOTO; Fiscal Year: 2013
    ..Exploit enzymatic activities resident within certain regulatory complexes as "partial reactions" that enable quantitative determination of regulatory mechanisms. ..
  44. Transcriptional Regulation of Estrogen Receptor (ER) by CARM1
    Wei Xu; Fiscal Year: 2012
    ..1, is involved in the activation of a number of transcriptional factors, including NF-?B, p53, E2F1 and steroid receptors, among which transcriptional activation of estrogen receptors (ERs) by CARM1 is best characterized...
  45. Small Molecule Src-2 Antagonists as Regulators of Sertoli Cell Function and Male
    David M Lonard; Fiscal Year: 2013
    ..In conjunction with support for compound chemistry that exists in this U54 application, we expect to generate SRC-2-targeting male contraceptive agents with the potential to be clinically viable. ..
  46. Vitamin D Receptor Coactivators in Keratinocytes
    DANIEL DAVID BIKLE; Fiscal Year: 2013
    ....
  47. Repressors in Prostate Cancer
    Michael G Rosenfeld; Fiscal Year: 2012
    ..The recruitment of TAB2 to serve as a molecular beacon for these events is specific to sex steroid receptors, reflective of evolutionarily conservation for key reproductive biological functions...
  48. MOLECULAR DETERMINANTS OF ANDROGEN RECEPTOR FUNCTION
    Elizabeth M Wilson; Fiscal Year: 2011
    ..abstract_text> ..
  49. To characterize nongenomic progestin receptors via knockouts in zebrafish
    Yong Zhu; Fiscal Year: 2013
    ..Our long- term goals are to determine the functions and signaling of nongenomic steroid receptors in vertebrates and to develop specific antagonists and agonists for fertility control or treatments of ..
  50. Genetic and Metabolic Fingerprints of Coativators "Program Project"
    BERT W O'MALLEY; Fiscal Year: 2013
    ..When complete, this PPG will afford a much greater understanding of NR and coregulator biology and will help define novel therapeutic leverage points for intervention of diseases associated with MS. ..
  51. The steroid receptor coactivator SRC-2 coordinates and modulates the metabolic, s
    ERIN LYNN REINEKE; Fiscal Year: 2013
    ..abstract_text> ..
  52. Mechanisms and synergies of therapeutic drug treatments in muscular dystrophy
    Jill A Rafael-Fortney; Fiscal Year: 2013
    ..targets the mineralocorticoid steroid hormone receptors, optimized pharmacological modulation of steroid receptors may provide a greatly improved treatment option for DMD patients...
  53. Non-Classical Cellular Pathways for Progesterone Regulation of Behavior
    Shailaja K Mani; Fiscal Year: 2013
    ..Specific aim 3 will test the hypothesis that a scaffolding protein integrates the rapid extranuclear signaling pathways with the intracellular PR-mediated genomic pathway in brain and behavior. ..
  54. Alterations of complex behaviors in sheep by pre-natal bisphenol A exposure
    Elizabeth M Peckham; Fiscal Year: 2013
    ..This is an important issue in society, since many products that mothers and young children are exposed to contain BPA. ..
  55. CENTER FOR REPRODUCTIVE BIOLOGICAL RESEARCH
    FRANCESCO JOHN DEMAYO; Fiscal Year: 2013
    ..abstract_text> ..
  56. Functional Characterization of FKBP52 Interactions with Steroid Hormone Receptors
    Marc B Cox; Fiscal Year: 2012
    ..Thus, we must use more sophisticated approaches to analyze direct interactions between the steroid receptors and associated cochaperones...
  57. Developing Neuroendocrine Brain, Androgen, and Fibroblast Growth Factor Signaling
    WILSON CHUNG; Fiscal Year: 2010
    ..Chung is a research associate with in depth knowledge about the role of steroid hormones, steroid receptors and growth factors during brain development...
  58. Depo-Provera and Breast Cancer: Epidemiology/Pathology
    Christopher Li; Fiscal Year: 2009
    ..such as parity and body mass index, modify this association?;and (3) Does the association between DMPA and breast cancer risk vary by histologic type or by the expression of steroid receptors including ERq, ERft, and PR?
  59. Dissecting the Functional Energetics of the Human Glucocorticoid Receptor
    James P Robblee; Fiscal Year: 2012
    ..An unanswered question in the steroid receptor field is how the different steroid receptors differentially regulate genes while recognizing nearly identical DNA sequences...
  60. Regulation of NF-kappaB transactivation function
    BRIAN ASHBURNER; Fiscal Year: 2009
    ..Through this work we will gain a much more thorough understanding of how the NF- kB transcriptional activation function is regulated. ..
  61. SEX HORMONE RECEPTOR COMPONENTS AND THE CELL GENOME
    BERT W O'MALLEY; Fiscal Year: 2013
    ....
  62. NOVEL ROLE AND REGULATION OF UTERINE TIMPS
    Warren Nothnick; Fiscal Year: 2000
    ..and quantitatively determine the effect of steroids and TIMP-1 on the spatiotemporal relationship among the steroid receptors and TIMP-1 and TIMP-3 in the uterus...
  63. MECHANISMS UNDERLYING ADRENAL STEROID MODULATION OF LTP
    Constantine Pavlides; Fiscal Year: 2000
    ..Further, the two types of adrenal steroid receptors, mineralocorticoid (MR) and glucocorticoid (GR), produce opposite effects in th dentate gyrus (DG) and CA1 ..
  64. NF-kappaB Regulation by Androgen Receptor
    ALBERT BALDWIN JR; Fiscal Year: 2004
    ..The experiments have the potential to identify a new target in the regulatory cascade associated with androgen/AR signaling and to possibly identify a new target for treatment of androgen-independent cancer. ..
  65. Timing of Dietary Exposures and Breast Cancer Risk
    Leena Hilakivi Clarke; Fiscal Year: 2001
    ..components to be studied include those which alter the activity of the estrogen receptor (ER) or other steroid receptors; i.e., fatty acids, phytoestrogens, heavy metals, calcium, and vitamins D and A...
  66. COMPLEMENTARY DNA PROBES TO A STEROID RECEPTOR GENE
    J Pike; Fiscal Year: 1992
    ..b>Steroid receptors may represent the best characterized subset of this family primarily because the recent molecular cloning of ..
  67. STEROID RECEPTOR TRANSFORMATION
    WILLIAM PRATT; Fiscal Year: 2005
    ..It is not known how signaling proteins, such as steroid receptors, STAT proteins or MAP kinases, move in precisely targeted manner through the cytoplasm to their nuclear ..
  68. ENDOGENOUS STEROID RECEPTOR STABILIZING FACTOR
    WILLIAM PRATT; Fiscal Year: 2000
    ..Dr. Pratt has shown that these three heat- shock proteins bind to each other independent of the presence of steroid receptors, and he postulates that the complex is involved in the very essential cellular functions of protein folding ..
  69. HORMONAL CONTROL OF THE OVIDUCT AND UTERUS
    HAROLD VERHAGE; Fiscal Year: 1990
    ..The steroid receptors will be quantitated using dextran coated charcoal and exchange assays...
  70. MONOAMINE AND RELATED REGULATORY SYSTEMS IN TOURETTE'S
    Brian Ciliax; Fiscal Year: 2003
    ..g.) gonadal steroid receptors or oxytoxin and vasopressin pathways that project to basal ganglia), which regulate the basal ganglia or ..